| Wednesday, January 16 |
| Future Cardinal Albert Pujols is born in Santo Domingo, D.R. |
| Friday, February 1 |
| Future Cardinal Hector Luna is born in Montecristi, D.R. |
| Saturday, February 2 |
| Former Cardinal Jack Rothrock dies in San Bernardino, CA at the age of 75. |
| Thursday, April 10 |
| » Defeated Pirates (0-1), 1-0 | Busch Stadium II (1-0) | 1-0 | |
| » W: Pete Vuckovich (1-0) L: Bert Blyleven (0-1) | First | -- |
| Friday, April 11 |
| » Lost to Pirates (1-1), 4-3 | Busch Stadium II (1-1) | 1-1 | |
| » W: Grant Jackson (1-0) L: Don Hood (0-1) | Second | ½ out |
| Saturday, April 12 |
| » Lost to Pirates (2-1), 7-2 | Busch Stadium II (1-2) | 1-2 | Lost 2 |
| » W: Jim Bibby (1-0) L: John Fulgham (0-1) | Third | 1½ out |
| Sunday, April 13 |
| » Lost to Pirates (3-1), 3-0 | Busch Stadium II (1-3) | 1-3 | Lost 3 |
| » W: Jim Rooker (1-0) L: Silvio Martinez (0-1) S: Grant Jackson (1) | Fifth | 2 out |
| Tuesday, April 15 |
| » Defeated Phillies (2-2), 7-2 | Busch Stadium II (2-3) | 2-3 | |
| » W: Pete Vuckovich (2-0) L: Randy Lerch (0-1) | Third | 2 out |
| Wednesday, April 16 |
| » Lost to Phillies (3-2), 8-3 | Busch Stadium II (2-4) | 2-4 | |
| » W: Steve Carlton (2-0) L: Bob Forsch (0-1) | Fifth | 2½ out |
| Thursday, April 17 |
| » Defeated Pirates (4-2), 12-9 | Three Rivers Stadium (1-0) | 3-4 | |
| » W: Bob Sykes (1-0) L: John Candelaria (0-1) | Fourth | 1½ out |
| » Major-league debuts: Rod Scurry (Pirates) |
| Friday, April 18 |
| » Lost to Pirates (5-2), 12-10 | Three Rivers Stadium (1-1) | 3-5 | |
| » W: Grant Jackson (2-0) L: Darold Knowles (0-1) S: Kent Tekulve (1) | Fourth | 2½ out |
| Saturday, April 19 |
| » Defeated Pirates (5-3), 2-1 | Three Rivers Stadium (2-1) | 4-5 | |
| » W: John Fulgham (1-1) L: Dave Roberts (0-1) | Third | 1½ out |
| Sunday, April 20 |
| » Lost to Pirates (6-3), 6-3 | Three Rivers Stadium (2-2) | 4-6 | |
| » W: Jim Rooker (2-0) L: Pete Vuckovich (2-1) S: Kent Tekulve (2) | Fourth | 2½ out |
| Tuesday, April 22 |
| » Lost to Cubs (6-3), 16-12 | Wrigley Field (0-1) | 4-7 | Lost 2 |
| » W: Bruce Sutter (1-1) L: Mark Littell (0-1) | Fifth | 4 out |
| Wednesday, April 23 |
| » Defeated Cubs (6-4), 3-1 | Wrigley Field (1-1) | 5-7 | |
| » W: Silvio Martinez (1-1) L: Mike Krukow (1-1) | Fourth | 3 out |
| Friday, April 25 |
| » Defeated Phillies (5-7), 3-1 | Veteran's Stadium (1-0) | 6-7 | Won 2 |
| » W: Pete Vuckovich (3-1) L: Randy Lerch (0-2) S: Mark Littell (1) | Third | 2 out |
| Saturday, April 26 |
| » Lost to Phillies (6-7), 7-0 | Veteran's Stadium (1-1) | 6-8 | |
| » W: Steve Carlton (3-1) L: John Fulgham (1-2) | Fourth | 3 out |
| Sunday, April 27 |
| » Defeated Phillies (6-8), 10-1 | Veteran's Stadium (2-1) | 7-8 | |
| » W: Bob Forsch (1-1) L: Dick Ruthven (1-2) | Third | 2½ out |
| Monday, April 28 |
| » Lost to Cubs (8-5), 4-2 | Busch Stadium II (2-5) | 7-9 | |
| » W: Willie Hernandez (1-1) L: Bob Sykes (1-1) S: Bruce Sutter (6) | Third | 3 out |
| Tuesday, April 29 |
| » Lost to Cubs (9-5), 6-4 | Busch Stadium II (2-6) | 7-10 | Lost 2 |
| » W: Doug Capilla (1-0) L: Bob Sykes (1-2) S: Bruce Sutter (7) | Fourth | 4 out |
| Wednesday, April 30 |
| » Defeated Cubs (9-6), 8-2 | Busch Stadium II (3-6) | 8-10 | |
| » W: Pete Vuckovich (4-1) L: Dennis Lamp (2-2) | Third | 4 out |
| Friday, May 2 |
| » Defeated Astros (14-6), 9-1 | Busch Stadium II (4-6) | 9-10 | Won 2 |
| » W: Don Hood (1-1) L: Nolan Ryan (1-1) S: Jim Kaat (1) | Third | 3½ out |
| Saturday, May 3 |
| » Lost to Astros (15-6), 4-2 | Busch Stadium II (4-7) | 9-11 | |
| » W: Vern Ruhle (1-1) L: Silvio Martinez (1-2) S: Joe Sambito (2) | Fourth | 3½ out |
| Sunday, May 4 |
| » Lost to Astros (16-6), 4-2 | Busch Stadium II (4-8) | 9-12 | Lost 2 |
| » W: Ken Forsch (4-0) L: Bob Sykes (1-3) S: Frank LaCorte (3) | Fourth | 4½ out |
| Monday, May 5 |
| » Defeated Giants (8-17), 9-5 | Busch Stadium II (5-8) | 10-12 | |
| » W: Pete Vuckovich (5-1) L: Vida Blue (2-2) S: Jim Kaat (2) | Fourth | 4 out |
| Tuesday, May 6 |
| » Defeated Giants (8-18), 10-7 | Busch Stadium II (6-8) | 11-12 | Won 2 |
| » W: Donnie Moore (1-0) L: Bob Knepper (2-3) S: Pedro Borbon (1) | Fourth | 4 out |
| Wednesday, May 7 |
| » Defeated Giants (8-19), 12-2 | Busch Stadium II (7-8) | 12-12 | Won 3 |
| » W: Bob Forsch (2-1) L: Ed Whitson (0-5) | Fourth | 4 out |
| Friday, May 9 |
| » Defeated Dodgers (14-12), 15-7 | Busch Stadium II (8-8) | 13-12 | Won 4 |
| » W: Pedro Borbon (1-0) L: Rick Sutcliffe (0-2) | Third | 4 out |
| Saturday, May 10 |
| » Lost to Dodgers (15-12), 5-3 | Busch Stadium II (8-9) | 13-13 | |
| » W: Burt Hooton (3-2) L: Pete Vuckovich (5-2) S: Jerry Reuss (2) | Third | 5 out |
| Sunday, May 11 |
| » Lost to Dodgers (16-12), 4-2 | Busch Stadium II (8-10) | 13-14 | Lost 2 |
| » W: Dave Goltz (3-2) L: Bob Forsch (2-2) S: Jerry Reuss (3) | Fourth | 5 out |
| Tuesday, May 13 |
| » Lost to Padres (15-15), 3-2 | San Diego/Jack Murphy Stadium (0-1) | 13-15 | Lost 3 |
| » W: Rollie Fingers (3-3) L: Jim Kaat (0-2) | Fourth | 5 out |
| Wednesday, May 14 |
| » Defeated Padres (15-16), 2-1 | San Diego/Jack Murphy Stadium (1-1) | 14-15 | |
| » W: Roy Thomas (1-0) L: Gary Lucas (2-1) S: Mark Littell (2) | Fourth | 5 out |
| Thursday, May 15 |
| » Lost to Padres (16-16), 2-1 | San Diego/Jack Murphy Stadium (1-2) | 14-16 | |
| » W: John Curtis (3-2) L: Pete Vuckovich (5-3) S: Rollie Fingers (4) | Fourth | 6 out |
| Friday, May 16 |
| » Lost to Giants (12-22), 4-3 | Candlestick Park (0-1) | 14-17 | Lost 2 |
| » W: Al Holland (1-0) L: Bob Forsch (2-3) | Fourth | 6 out |
| Saturday, May 17 |
| » Lost to Giants (13-22), 4-2 | Candlestick Park (0-2) | 14-18 | Lost 3 |
| » W: Vida Blue (5-2) L: Bob Sykes (1-4) S: Gary Lavelle (2) | Fourth | 6 out |
| Sunday, May 18 |
| » Lost to Giants (14-22), 6-5 | Candlestick Park (0-3) | 14-19 | Lost 4 |
| » W: Bob Knepper (3-5) L: Don Hood (1-2) S: Al Holland (2) | Fifth | 6 out |
| Monday, May 19 |
| » Lost to Dodgers (22-13), 5-1 | Dodger Stadium (0-1) | 14-20 | Lost 5 |
| » W: Burt Hooton (4-3) L: Roy Thomas (1-1) | Fifth | 6½ out |
| Tuesday, May 20 |
| » Lost to Dodgers (23-13), 4-3 | Dodger Stadium (0-2) | 14-21 | Lost 6 |
| » W: Jerry Reuss (5-0) L: Pete Vuckovich (5-4) S: Rick Sutcliffe (2) | Fifth | 7 out |
| Wednesday, May 21 |
| » Lost to Dodgers (24-13), 5-3 | Dodger Stadium (0-3) | 14-22 | Lost 7 |
| » W: Joe Beckwith (3-0) L: Mark Littell (0-2) S: Bobby Castillo (2) | Sixth | 8½ out |
| Friday, May 23 |
| » Lost to Padres (20-19), 2-0 | Busch Stadium II (8-11) | 14-23 | Lost 8 |
| » W: Bob Shirley (4-1) L: Jim Kaat (0-3) | Sixth | 9 out |
| Saturday, May 24 |
| » Lost to Padres (21-19), 8-4 | Busch Stadium II (8-12) | 14-24 | Lost 9 |
| » W: Dennis Kinney (1-1) L: Donnie Moore (1-1) | Sixth | 9 out |
| Sunday, May 25 |
| » Lost to Padres (22-19), 11-5 | Busch Stadium II (8-13) | 14-25 | Lost 10 |
| » W: Rollie Fingers (5-4) L: Roy Thomas (1-2) S: John D'Acquisto (1) | Sixth | 9 out |
| Monday, May 26 |
| » Defeated Mets (16-22), 8-5 | Busch Stadium II (9-13) | 15-25 | |
| » W: Bob Forsch (3-3) L: Pete Falcone (3-3) | Sixth | 8 out |
| Tuesday, May 27 |
| » Lost to Mets (17-22), 9-5 | Busch Stadium II (9-14) | 15-26 | |
| » W: Mark Bomback (3-0) L: Silvio Martinez (1-3) | Sixth | 9 out |
| » Major-league debuts: Leon Durham (Cardinals) |
| Wednesday, May 28 |
| » Lost to Mets (18-22), 6-5 | Busch Stadium II (9-15) | 15-27 | Lost 2 |
| » W: Kevin Kobel (1-4) L: George Frazier (0-1) S: Neil Allen (9) | Sixth | 9 out |
| Friday, May 30 |
| » Lost to Expos (21-18), 10-4 | Busch Stadium II (9-16) | 15-28 | Lost 3 |
| » W: Scott Sanderson (5-3) L: Jim Kaat (0-4) | Sixth | 9½ out |
| Saturday, May 31 |
| » Defeated Expos (21-19), 8-6 | Busch Stadium II (10-16) | 16-28 | |
| » W: Bob Forsch (4-3) L: Steve Rogers (5-5) S: Pete Vuckovich (1) | Sixth | 9½ out |
| Sunday, June 1 |
| » Lost to Expos (22-19), 7-6 | Busch Stadium II (10-17) | 16-29 | |
| » W: Stan Bahnsen (4-1) L: George Frazier (0-2) S: Fred Norman (2) | Sixth | 10½ out |
| Tuesday, June 3 |
| » Defeated Mets (19-25), 8-1 | Shea Stadium (1-0) | 17-29 | |
| » W: John Fulgham (2-2) L: Ray Burris (3-4) | Sixth | 11 out |
| Wednesday, June 4 |
| » Defeated Mets (19-26), 1-0 | Shea Stadium (2-0) | 18-29 | Won 2 |
| » W: Jim Kaat (1-4) L: Neil Allen (2-4) | Sixth | 10 out |
| Thursday, June 5 |
| » Lost to Mets (20-26), 2-1 | Shea Stadium (2-1) | 18-30 | |
| » W: Craig Swan (4-4) L: George Frazier (0-3) | Sixth | 10½ out |
| Friday, June 6 |
| » Lost to Expos (26-20), 7-2 | Stade Olympique (0-1) | 18-31 | Lost 2 |
| » W: Bill Lee (3-4) L: Bob Forsch (4-4) | Sixth | 10½ out |
| Saturday, June 7 |
| » Lost to Expos (27-20), 2-1 | Stade Olympique (0-2) | 18-32 | Lost 3 |
| » W: Elias Sosa (3-2) L: Jim Otten (0-1) | Sixth | 10½ out |
| Sunday, June 8 |
| » Lost to Expos (28-20), 6-4 | Stade Olympique (0-3) | 18-33 | Lost 4 |
| » W: Steve Rogers (7-5) L: John Fulgham (2-3) S: Woodie Fryman (8) | Sixth | 12½ out |
| » Lost to Expos (29-20), 9-4 | Stade Olympique (0-4) | 18-34 | Lost 5 |
| » Manager: Jack Krol |
| » W: Ross Grimsley (2-3) L: Roy Thomas (1-3) | Sixth | 12½ out |
| » Major-league debuts: Brad Mills (Expos) John Littlefield (Cardinals) |
| Monday, June 9 |
| » Defeated Braves (21-30), 8-5 | Atlanta-Fulton County Stadium (1-0) | 19-34 | |
| » Manager: Whitey Herzog |
| » W: John Littlefield (1-0) L: Larry Bradford (1-3) S: George Frazier (1) | Sixth | 12 out |
| Tuesday, June 10 |
| » Lost to Braves (22-30), 5-2 | Atlanta-Fulton County Stadium (1-1) | 19-35 | |
| » W: Phil Niekro (5-8) L: Bob Sykes (1-5) | Sixth | 13 out |
| Wednesday, June 11 |
| » Defeated Braves (22-31), 4-3 | Atlanta-Fulton County Stadium (2-1) | 20-35 | |
| » W: Bob Forsch (5-4) L: Larry Bradford (1-4) S: Kim Seaman (1) | Sixth | 13 out |
| Thursday, June 12 |
| » Major-league debuts: Charlie Lea (Expos) |
| Friday, June 13 |
| » Lost to Reds (32-25), 5-2 | Busch Stadium II (10-18) | 20-36 | |
| » W: Charlie Leibrandt (6-3) L: Pete Vuckovich (5-5) S: Tom Hume (10) | Sixth | 14½ out |
| Saturday, June 14 |
| » Defeated Reds (32-26), 4-3 | Busch Stadium II (11-18) | 21-36 | |
| » W: John Littlefield (2-0) L: Mario Soto (0-2) | Sixth | 13½ out |
| » Major-league debuts: Joe Price (Reds) |
| Sunday, June 15 |
| » Defeated Reds (32-27), 10-9 | Busch Stadium II (12-18) | 22-36 | Won 2 |
| » W: Roy Thomas (2-3) L: Paul Moskau (4-1) | Sixth | 12½ out |
| Monday, June 16 |
| » Lost to Braves (24-33), 6-3 | Busch Stadium II (12-19) | 22-37 | |
| » W: Tommy Boggs (3-2) L: Bob Forsch (5-5) | Sixth | 12½ out |
| Tuesday, June 17 |
| » Defeated Braves (24-34), 3-2 | Busch Stadium II (13-19) | 23-37 | |
| » W: Pete Vuckovich (6-5) L: Doyle Alexander (4-3) | Sixth | 12½ out |
| Wednesday, June 18 |
| » Lost to Astros (37-23), 3-0 | Astrodome (0-1) | 23-38 | |
| » W: Joe Niekro (7-5) L: Jim Kaat (1-5) | Sixth | 12½ out |
| Thursday, June 19 |
| » Lost to Astros (38-23), 2-0 | Astrodome (0-2) | 23-39 | Lost 2 |
| » W: Nolan Ryan (5-5) L: Bob Sykes (1-6) S: Joe Sambito (6) | Sixth | 12½ out |
| Friday, June 20 |
| » Defeated Reds (33-31), 7-5 | Riverfront Stadium (1-0) | 24-39 | |
| » W: Kim Seaman (1-0) L: Tom Hume (3-7) S: John Littlefield (1) | Sixth | 11½ out |
| Saturday, June 21 |
| » Lost to Reds (34-31), 8-5 | Riverfront Stadium (1-1) | 24-40 | |
| » W: Frank Pastore (9-3) L: John Littlefield (2-1) | Sixth | 12½ out |
| Sunday, June 22 |
| » Defeated Reds (34-32), 12-2 | Riverfront Stadium (2-1) | 25-40 | |
| » W: Pete Vuckovich (7-5) L: Mike LaCoss (4-7) | Sixth | 12½ out |
| Monday, June 23 |
| » Defeated Pirates (35-31), 6-1 | Busch Stadium II (14-19) | 26-40 | Won 2 |
| » W: Jim Kaat (2-5) L: Eddie Solomon (4-1) | Sixth | 12 out |
| Tuesday, June 24 |
| » Defeated Pirates (35-32), 3-2 | Busch Stadium II (15-19) | 27-40 | Won 3 |
| » W: Bob Sykes (2-6) L: Rick Rhoden (0-1) | Sixth | 12 out |
| Wednesday, June 25 |
| » Defeated Pirates (35-33), 4-1 | Busch Stadium II (16-19) | 28-40 | Won 4 |
| » W: Don Hood (2-2) L: John Candelaria (4-7) S: Kim Seaman (2) | Sixth | 11 out |
| Friday, June 27 |
| » Defeated Cubs (29-37), 3-2 | Wrigley Field (2-1) | 29-40 | Won 5 |
| » W: Kim Seaman (2-0) L: Willie Hernandez (1-7) | Sixth | 10½ out |
| Saturday, June 28 |
| » Defeated Cubs (29-38), 8-6 | Wrigley Field (3-1) | 30-40 | Won 6 |
| » W: John Littlefield (3-1) L: Bruce Sutter (3-4) | Sixth | 10 out |
| » Lost to Cubs (30-38), 2-1 | Wrigley Field (3-2) | 30-41 | |
| » W: Mike Krukow (6-8) L: Jim Otten (0-2) | Sixth | 10 out |
| Sunday, June 29 |
| » Defeated Cubs (30-39), 9-7 | Wrigley Field (4-2) | 31-41 | |
| » W: John Urrea (1-0) L: Lynn McGlothen (5-5) S: John Littlefield (2) | Sixth | 10 out |
| Monday, June 30 |
| » Lost to Pirates (38-34), 5-4 | Three Rivers Stadium (2-3) | 31-42 | |
| » W: Enrique Romo (5-3) L: Don Hood (2-3) | Sixth | 10 out |
| Tuesday, July 1 |
| » Lost to Pirates (39-34), 3-2 | Three Rivers Stadium (2-4) | 31-43 | Lost 2 |
| » W: Grant Jackson (6-2) L: Jim Kaat (2-6) | Sixth | 10 out |
| Wednesday, July 2 |
| » Defeated Pirates (39-35), 7-5 | Three Rivers Stadium (3-4) | 32-43 | |
| » W: John Urrea (2-0) L: Rod Scurry (0-2) | Sixth | 10 out |
| Thursday, July 3 |
| » Lost to Phillies (39-33), 2-1 | Busch Stadium II (16-20) | 32-44 | |
| » W: Dick Ruthven (7-5) L: Bob Forsch (5-6) | Sixth | 10½ out |
| » Lost to Phillies (40-33), 8-1 | Busch Stadium II (16-21) | 32-45 | Lost 2 |
| » W: Bob Walk (4-0) L: Jim Otten (0-3) | Sixth | 10½ out |
| Friday, July 4 |
| » Defeated Phillies (40-34), 1-0 | Busch Stadium II (17-21) | 33-45 | |
| » W: Bob Sykes (3-6) L: Kevin Saucier (3-3) | Sixth | 10 out |
| Saturday, July 5 |
| » Defeated Phillies (40-35), 6-1 | Busch Stadium II (18-21) | 34-45 | Won 2 |
| » W: Jim Kaat (3-6) L: Randy Lerch (3-11) | Sixth | 9 out |
| Sunday, July 6 |
| » Lost to Phillies (41-35), 8-3 | Busch Stadium II (18-22) | 34-46 | |
| » W: Steve Carlton (14-4) L: Pete Vuckovich (7-6) | Sixth | 10 out |
| Thursday, July 10 |
| » Lost to Expos (43-34), 4-3 | Stade Olympique (0-5) | 34-47 | Lost 2 |
| » W: David Palmer (6-2) L: John Littlefield (3-2) S: Woodie Fryman (10) | Sixth | 11 out |
| Friday, July 11 |
| » Defeated Expos (43-35), 5-3 | Stade Olympique (1-5) | 35-47 | |
| » W: Silvio Martinez (2-3) L: Woodie Fryman (3-4) S: John Littlefield (3) | Fourth | 10 out |
| Saturday, July 12 |
| » Defeated Mets (39-42), 8-6 | Shea Stadium (3-1) | 36-47 | Won 2 |
| » W: John Littlefield (4-2) L: Ed Glynn (3-2) | Fifth | 10 out |
| Sunday, July 13 |
| » Lost to Mets (40-42), 7-4 | Shea Stadium (3-2) | 36-48 | |
| » W: Pete Falcone (5-5) L: Bob Sykes (3-7) | Fifth | 11 out |
| » Lost to Mets (41-42), 10-4 | Shea Stadium (3-3) | 36-49 | Lost 2 |
| » W: Mark Bomback (6-2) L: Jim Otten (0-4) | Fifth | 11 out |
| Monday, July 14 |
| » Major-league debuts: Alan Hargesheimer (Giants) |
| Tuesday, July 15 |
| » Defeated Padres (37-50), 5-3 | Busch Stadium II (19-22) | 37-49 | |
| » W: Bob Forsch (6-6) L: Randy Jones (4-8) S: John Littlefield (4) | Fifth | 10 out |
| Wednesday, July 16 |
| » Defeated Padres (37-51), 3-0 | Busch Stadium II (20-22) | 38-49 | Won 2 |
| » W: Pete Vuckovich (8-6) L: Gary Lucas (3-5) | Fifth | 10 out |
| Thursday, July 17 |
| » Defeated Padres (37-52), 15-3 | Busch Stadium II (21-22) | 39-49 | Won 3 |
| » W: Jim Kaat (4-6) L: Rick Wise (3-5) | Fifth | 10 out |
| Friday, July 18 |
| » Lost to Giants (44-46), 8-7 | Busch Stadium II (21-23) | 39-50 | |
| » W: Al Holland (3-2) L: Kim Seaman (2-1) | Fifth | 11 out |
| Saturday, July 19 |
| » Lost to Giants (45-46), 7-4 | Busch Stadium II (21-24) | 39-51 | Lost 2 |
| » W: Alan Hargesheimer (2-0) L: Bob Sykes (3-8) S: Gary Lavelle (5) | Fifth | 11½ out |
| Sunday, July 20 |
| » Defeated Giants (45-47), 2-1 | Busch Stadium II (22-24) | 40-51 | |
| » W: Bob Forsch (7-6) L: Bob Knepper (8-11) | Fifth | 11 out |
| Monday, July 21 |
| » Defeated Dodgers (51-42), 5-2 | Busch Stadium II (23-24) | 41-51 | Won 2 |
| » W: Pete Vuckovich (9-6) L: Dave Goltz (3-7) S: John Littlefield (5) | Fifth | 10½ out |
| Tuesday, July 22 |
| » Defeated Dodgers (51-43), 3-2 | Busch Stadium II (24-24) | 42-51 | Won 3 |
| » W: John Urrea (3-0) L: Don Sutton (7-3) S: John Littlefield (6) | Fifth | 10½ out |
| Wednesday, July 23 |
| » Defeated Dodgers (51-44), 7-3 | Busch Stadium II (25-24) | 43-51 | Won 4 |
| » W: Silvio Martinez (3-3) L: Bob Welch (9-5) | Fifth | 9½ out |
| » Major-league debuts: Tito Landrum (Cardinals) |
| Friday, July 25 |
| » Defeated Padres (39-57), 3-2 | San Diego/Jack Murphy Stadium (2-2) | 44-51 | Won 5 |
| » W: Bob Sykes (4-8) L: Dennis Kinney (3-3) S: John Littlefield (7) | Fifth | 10 out |
| Saturday, July 26 |
| » Lost to Padres (40-57), 4-3 | San Diego/Jack Murphy Stadium (2-3) | 44-52 | |
| » W: Dennis Kinney (4-3) L: Don Hood (2-4) | Fifth | 10 out |
| Sunday, July 27 |
| » Lost to Padres (41-57), 5-2 | San Diego/Jack Murphy Stadium (2-4) | 44-53 | Lost 2 |
| » W: Gary Lucas (4-6) L: Pete Vuckovich (9-7) S: Rollie Fingers (12) | Fifth | 11 out |
| Tuesday, July 29 |
| » Lost to Giants (49-50), 4-1 | Candlestick Park (0-4) | 44-54 | Lost 3 |
| » W: Allen Ripley (5-4) L: Silvio Martinez (3-4) S: Greg Minton (9) | Fifth | 11½ out |
| Wednesday, July 30 |
| » Defeated Giants (49-51), 4-0 | Candlestick Park (1-4) | 45-54 | |
| » W: John Fulgham (3-3) L: Bob Knepper (8-13) | Fifth | 10½ out |
| Thursday, July 31 |
| » Lost to Giants (50-51), 6-4 | Candlestick Park (1-5) | 45-55 | |
| » W: Gary Lavelle (4-5) L: John Urrea (3-1) S: Al Holland (4) | Fifth | 11 out |
| Friday, August 1 |
| » Lost to Dodgers (56-46), 2-1 | Dodger Stadium (0-4) | 45-56 | Lost 2 |
| » W: Dave Goltz (4-7) L: Bob Forsch (7-7) | Fifth | 11 out |
| Saturday, August 2 |
| » Lost to Dodgers (57-46), 3-2 | Dodger Stadium (0-5) | 45-57 | Lost 3 |
| » W: Bob Welch (10-6) L: Pete Vuckovich (9-8) S: Don Stanhouse (1) | Fifth | 12 out |
| Sunday, August 3 |
| » Defeated Dodgers (57-47), 4-1 | Dodger Stadium (1-5) | 46-57 | |
| » W: Silvio Martinez (4-4) L: Burt Hooton (10-4) | Fifth | 12 out |
| Wednesday, August 6 |
| » Defeated Phillies (54-48), 14-0 | Veteran's Stadium (3-1) | 47-57 | Won 2 |
| » W: Bob Sykes (5-8) L: Bob Walk (8-2) | Fifth | 12½ out |
| Thursday, August 7 |
| » Lost to Phillies (55-48), 3-2 | Veteran's Stadium (3-2) | 47-58 | |
| » W: Steve Carlton (17-6) L: John Fulgham (3-4) S: Tug McGraw (11) | Fifth | 12½ out |
| Friday, August 8 |
| » Lost to Mets (53-55), 3-2 | Busch Stadium II (25-25) | 47-59 | Lost 2 |
| » W: Jeff Reardon (7-6) L: John Littlefield (4-3) S: Neil Allen (19) | Fifth | 13 out |
| Saturday, August 9 |
| » Defeated Mets (53-56), 9-6 | Busch Stadium II (26-25) | 48-59 | |
| » W: John Urrea (4-1) L: Tom Hausman (4-3) S: Jim Kaat (3) | Fifth | 12½ out |
| Sunday, August 10 |
| » Lost to Mets (54-56), 4-1 | Busch Stadium II (26-26) | 48-60 | |
| » W: Mark Bomback (9-3) L: Silvio Martinez (4-5) S: Neil Allen (20) | Fourth | 13½ out |
| Monday, August 11 |
| » Defeated Expos (63-49), 16-0 | Busch Stadium II (27-26) | 49-60 | |
| » W: Bob Sykes (6-8) L: Scott Sanderson (12-6) | Fifth | 13½ out |
| Tuesday, August 12 |
| » Lost to Expos (64-49), 4-0 | Busch Stadium II (27-27) | 49-61 | |
| » W: Fred Norman (3-2) L: John Fulgham (3-5) S: Woodie Fryman (13) | Fourth | 13½ out |
| Wednesday, August 13 |
| » Defeated Expos (64-50), 7-5 | Busch Stadium II (28-27) | 50-61 | |
| » W: Bob Forsch (8-7) L: Hal Dues (0-1) S: Jim Kaat (4) | Fourth | 12½ out |
| Thursday, August 14 |
| » Defeated Cubs (46-67), 10-9 | Busch Stadium II (29-27) | 51-61 | Won 2 |
| » W: Jim Kaat (5-6) L: George Riley (0-3) | Fourth | 12 out |
| Friday, August 15 |
| » Lost to Cubs (47-67), 5-4 | Busch Stadium II (29-28) | 51-62 | |
| » W: Lynn McGlothen (9-7) L: Silvio Martinez (4-6) S: Bruce Sutter (25) | Fifth | 13 out |
| Saturday, August 16 |
| » Lost to Cubs (48-67), 9-4 | Busch Stadium II (29-29) | 51-63 | Lost 2 |
| » W: Mike Krukow (8-12) L: Bob Sykes (6-9) S: Bruce Sutter (26) | Fifth | 14 out |
| Sunday, August 17 |
| » Lost to Cubs (49-67), 6-2 | Busch Stadium II (29-30) | 51-64 | Lost 3 |
| » W: Rick Reuschel (10-9) L: John Fulgham (3-6) | Fifth | 14½ out |
| Monday, August 18 |
| » Defeated Reds (64-55), 10-1 | Riverfront Stadium (3-1) | 52-64 | |
| » W: Bob Forsch (9-7) L: Charlie Leibrandt (10-8) | Fifth | 14 out |
| Tuesday, August 19 |
| » Lost to Reds (65-55), 4-2 | Riverfront Stadium (3-2) | 52-65 | |
| » W: Mike LaCoss (7-9) L: Silvio Martinez (4-7) S: Doug Bair (6) | Fifth | 14 out |
| Wednesday, August 20 |
| » Lost to Reds (66-55), 4-3 | Riverfront Stadium (3-3) | 52-66 | Lost 2 |
| » W: Joe Price (4-2) L: Don Hood (2-5) | Fifth | 14 out |
| Friday, August 22 |
| » Defeated Braves (58-63), 7-4 | Atlanta-Fulton County Stadium (3-1) | 53-66 | |
| » W: John Fulgham (4-6) L: Rick Matula (7-12) | Fifth | 13½ out |
| Saturday, August 23 |
| » Lost to Braves (59-63), 7-2 | Atlanta-Fulton County Stadium (3-2) | 53-67 | |
| » W: Doyle Alexander (12-6) L: Pete Vuckovich (9-9) | Fifth | 14½ out |
| Sunday, August 24 |
| » Lost to Braves (60-63), 10-5 | Atlanta-Fulton County Stadium (3-3) | 53-68 | Lost 2 |
| » W: Tommy Boggs (7-8) L: Silvio Martinez (4-8) | Fifth | 15½ out |
| Monday, August 25 |
| » Defeated Astros (70-54), 3-1 | Busch Stadium II (30-30) | 54-68 | |
| » W: Don Hood (3-5) L: Vern Ruhle (7-3) | Fifth | 14½ out |
| Tuesday, August 26 |
| » Lost to Astros (71-54), 7-2 | Busch Stadium II (30-31) | 54-69 | |
| » W: Joe Niekro (14-11) L: Jim Kaat (5-7) | Fifth | 14½ out |
| Wednesday, August 27 |
| » Defeated Astros (71-55), 10-2 | Busch Stadium II (31-31) | 55-69 | |
| » W: John Martin (1-0) L: Ken Forsch (10-11) | Fifth | 13½ out |
| » Major-league debuts: John Martin (Cardinals) |
| Thursday, August 28 |
| » Defeated Braves (63-64), 11-2 | Busch Stadium II (32-31) | 56-69 | Won 2 |
| » W: Bob Forsch (10-7) L: Doyle Alexander (12-7) | Fifth | 12½ out |
| Friday, August 29 |
| » Lost to Braves (64-64), 4-3 | Busch Stadium II (32-32) | 56-70 | |
| » Manager: Red Schoendienst |
| » W: Tommy Boggs (8-8) L: Silvio Martinez (4-9) S: Rick Camp (11) | Fifth | 12½ out |
| Saturday, August 30 |
| » Defeated Braves (64-65), 5-3 | Busch Stadium II (33-32) | 57-70 | |
| » W: Don Hood (4-5) L: Larry McWilliams (9-10) S: John Urrea (1) | Fifth | 11½ out |
| Sunday, August 31 |
| » Lost to Braves (65-65), 6-2 | Busch Stadium II (33-33) | 57-71 | |
| » W: Phil Niekro (12-14) L: Jim Otten (0-5) | Fifth | 11½ out |
| Monday, September 1 |
| » Lost to Reds (72-59), 8-1 | Busch Stadium II (33-34) | 57-72 | Lost 2 |
| » W: Joe Price (5-2) L: Jim Kaat (5-8) | Fifth | 12 out |
| Tuesday, September 2 |
| » Defeated Reds (72-60), 12-4 | Busch Stadium II (34-34) | 58-72 | |
| » W: Bob Forsch (11-7) L: Paul Moskau (9-6) S: John Littlefield (8) | Fifth | 12 out |
| » Major-league debuts: Eddie Milner (Reds) |
| Wednesday, September 3 |
| » Defeated Reds (72-61), 4-3 | Busch Stadium II (35-34) | 59-72 | Won 2 |
| » W: Jim Kaat (6-8) L: Tom Hume (7-9) | Fourth | 12 out |
| Thursday, September 4 |
| » Major-league debuts: Fred Breining (Giants) |
| Friday, September 5 |
| » Defeated Astros (75-59), 7-5 | Astrodome (1-2) | 60-72 | Won 3 |
| » W: Kim Seaman (3-1) L: Joe Sambito (8-4) S: George Frazier (2) | Fourth | 11½ out |
| Saturday, September 6 |
| » Lost to Astros (76-59), 9-5 | Astrodome (1-3) | 60-73 | |
| » W: Joe Niekro (15-11) L: Bob Sykes (6-10) S: Randy Niemann (1) | Fourth | 13 out |
| » Lost to Astros (77-59), 6-4 | Astrodome (1-4) | 60-74 | Lost 2 |
| » W: Vern Ruhle (9-3) L: John Martin (1-1) | Fourth | 13 out |
| Sunday, September 7 |
| » Defeated Astros (77-60), 2-0 | Astrodome (2-4) | 61-74 | |
| » W: Pete Vuckovich (10-9) L: Ken Forsch (10-12) | Fourth | 12 out |
| Monday, September 8 |
| » Lost to Cubs (54-82), 6-2 | Busch Stadium II (35-35) | 61-75 | |
| » W: Lynn McGlothen (10-11) L: Bob Forsch (11-8) | Fourth | 12½ out |
| Tuesday, September 9 |
| » Defeated Cubs (54-83), 6-4 | Busch Stadium II (36-35) | 62-75 | |
| » W: Silvio Martinez (5-9) L: Doug Capilla (2-6) S: Kim Seaman (3) | Fourth | 12½ out |
| Wednesday, September 10 |
| » Lost to Pirates (73-67), 7-6 | Busch Stadium II (36-36) | 62-76 | |
| » W: Jim Bibby (16-5) L: Don Hood (4-6) S: Enrique Romo (10) | Fourth | 13½ out |
| Thursday, September 11 |
| » Lost to Pirates (74-67), 2-1 | Busch Stadium II (36-37) | 62-77 | Lost 2 |
| » W: Bert Blyleven (8-11) L: John Martin (1-2) | Fourth | 14½ out |
| Friday, September 12 |
| » Defeated Phillies (76-64), 7-4 | Veteran's Stadium (4-2) | 63-77 | |
| » W: Pete Vuckovich (11-9) L: Bob Walk (10-5) S: John Urrea (2) | Fourth | 14 out |
| » Defeated Phillies (76-65), 5-0 | Veteran's Stadium (5-2) | 64-77 | Won 2 |
| » W: John Littlefield (5-3) L: Ron Reed (7-5) | Fourth | 14 out |
| » Major-league debuts: Mark Davis (Phillies) |
| Saturday, September 13 |
| » Lost to Phillies (77-65), 2-1 | Veteran's Stadium (5-3) | 64-78 | |
| » W: Steve Carlton (22-8) L: Bob Forsch (11-9) | Fourth | 14 out |
| Sunday, September 14 |
| » Lost to Phillies (78-65), 8-4 | Veteran's Stadium (5-4) | 64-79 | Lost 2 |
| » W: Marty Bystrom (2-0) L: Silvio Martinez (5-10) | Fourth | 15 out |
| Monday, September 15 |
| » Defeated Cubs (55-88), 5-1 | Wrigley Field (5-2) | 65-79 | |
| » W: Andy Rincon (1-0) L: Doug Capilla (2-7) | Fourth | 14½ out |
| » Major-league debuts: Andy Rincon (Cardinals) |
| Tuesday, September 16 |
| » Lost to Cubs (56-88), 6-5 | Wrigley Field (5-3) | 65-80 | |
| » W: Bill Caudill (2-5) L: John Littlefield (5-4) | Fourth | 16 out |
| Wednesday, September 17 |
| » Defeated Cubs (56-89), 8-5 | Wrigley Field (6-3) | 66-80 | |
| » W: Pete Vuckovich (12-9) L: Mike Krukow (8-15) | Fourth | 15 out |
| Future Cardinal Danny Haren is born in Monterey Park, CA. |
| Friday, September 19 |
| » Defeated Expos (81-66), 9-8 | Busch Stadium II (37-37) | 67-80 | Won 2 |
| » W: Jim Kaat (7 |
