| Sunday, February 10 |
| Future Blue Jay Cesar Izturis is born in Lara, Venezuela. |
| Wednesday, April 9 |
| » Lost to Mariners (1-0), 8-6 | Kingdome (0-1) | 0-1 | |
| » W: Mike Parrott (1-0) L: Dave Lemanczyk (0-1) S: Dave Heaverlo (1) | Second | ½ out |
| Friday, April 11 |
| » Defeated Mariners (1-1), 10-7 | Kingdome (1-1) | 1-1 | |
| » W: Balor Moore (1-0) L: Rob Dressler (0-1) | Second | ½ out |
| Saturday, April 12 |
| » Lost to Mariners (2-1), 3-2 | Kingdome (1-2) | 1-2 | |
| » W: Rick Honeycutt (1-0) L: Jerry Garvin (0-1) | Third | 1½ out |
| Sunday, April 13 |
| » Lost to Mariners (3-1), 5-1 | Kingdome (1-3) | 1-3 | Lost 2 |
| » W: Floyd Bannister (1-0) L: Dave Lemanczyk (0-2) | Fourth | 1½ out |
| Wednesday, April 16 |
| » Defeated Brewers (2-2), 11-2 | Exhibition Stadium (1-0) | 2-3 | |
| » W: Dave Stieb (1-0) L: Jim Slaton (0-1) | Fourth | 1 out |
| Thursday, April 17 |
| » Defeated Brewers (2-3), 1-0 | Exhibition Stadium (2-0) | 3-3 | Won 2 |
| » W: Paul Mirabella (1-0) L: Lary Sorensen (1-1) | Third | 1 out |
| Saturday, April 19 |
| » Lost to Indians (2-5), 8-1 | Cleveland Stadium (0-1) | 3-4 | |
| » W: Rick Waits (1-1) L: Jim Clancy (0-1) | Fourth | 1 out |
| Sunday, April 20 |
| » Defeated Indians (2-6), 5-3 | Cleveland Stadium (1-1) | 4-4 | |
| » W: Dave Lemanczyk (1-2) L: John Denny (0-2) S: Joey McLaughlin (1) | Second | ½ out |
| Monday, April 21 |
| » Defeated Royals (5-6), 7-1 | Royals Stadium (1-0) | 5-4 | Won 2 |
| » W: Dave Stieb (2-0) L: Rich Gale (0-2) | Second | ½ out |
| Tuesday, April 22 |
| » Lost to Royals (6-6), 7-2 | Royals Stadium (1-1) | 5-5 | |
| » W: Paul Splittorff (2-0) L: Paul Mirabella (1-1) | Third | 1 out |
| Wednesday, April 23 |
| » Lost to Royals (7-6), 7-4 | Royals Stadium (1-2) | 5-6 | Lost 2 |
| » W: Gary Christenson (1-0) L: Joey McLaughlin (0-1) S: Dan Quisenberry (2) | Third | 1 out |
| Friday, April 25 |
| » Defeated Brewers (6-6), 5-3 | County Stadium (1-0) | 6-6 | |
| » W: Joey McLaughlin (1-1) L: Lary Sorensen (1-2) | First | -- |
| Saturday, April 26 |
| » Defeated Brewers (6-7), 4-0 | County Stadium (2-0) | 7-6 | Won 2 |
| » W: Dave Stieb (3-0) L: Mike Caldwell (2-1) | First | -- |
| Sunday, April 27 |
| » Defeated Brewers (6-8), 8-2 | County Stadium (3-0) | 8-6 | Won 3 |
| » W: Paul Mirabella (2-1) L: Moose Haas (1-3) S: Balor Moore (1) | First | -- |
| Tuesday, April 29 |
| » Defeated Royals (9-8), 3-1 | Exhibition Stadium (3-0) | 9-6 | Won 4 |
| » W: Jim Clancy (1-1) L: Dennis Leonard (0-3) | First | -- |
| Wednesday, April 30 |
| » Lost to Royals (10-8), 3-0 | Exhibition Stadium (3-1) | 9-7 | |
| » W: Larry Gura (3-1) L: Jesse Jefferson (0-1) | First | -- |
| Thursday, May 1 |
| » Lost to Indians (6-10), 2-1 | Exhibition Stadium (3-2) | 9-8 | Lost 2 |
| » W: John Denny (1-2) L: Dave Lemanczyk (1-3) S: Sid Monge (2) | First | -- |
| Friday, May 2 |
| » Lost to Indians (7-10), 6-1 | Exhibition Stadium (3-3) | 9-9 | Lost 3 |
| » W: Len Barker (3-1) L: Dave Stieb (3-1) | Third | ½ out |
| Saturday, May 3 |
| » Defeated Indians (7-11), 8-3 | Exhibition Stadium (4-3) | 10-9 | |
| » W: Tom Buskey (1-0) L: Rick Waits (1-3) | Third | ½ out |
| Sunday, May 4 |
| » Defeated Indians (7-12), 9-8 | Exhibition Stadium (5-3) | 11-9 | Won 2 |
| » W: Tom Buskey (2-0) L: Sid Monge (0-1) | First | -- |
| » Defeated Indians (7-13), 7-2 | Exhibition Stadium (6-3) | 12-9 | Won 3 |
| » W: Jesse Jefferson (1-1) L: Bob Owchinko (0-3) S: Joey McLaughlin (2) | First | -- |
| Tuesday, May 6 |
| » Defeated Angels (11-12), 3-2 | Anaheim Stadium (1-0) | 13-9 | Won 4 |
| » W: Dave Lemanczyk (2-3) L: Don Aase (3-2) S: Jerry Garvin (1) | First | -- |
| » Major-league debuts: Stan Cliburn (Angels) |
| Wednesday, May 7 |
| » Defeated Angels (11-13), 7-3 | Anaheim Stadium (2-0) | 14-9 | Won 5 |
| » W: Dave Stieb (4-1) L: Chris Knapp (0-2) | First | -- |
| Thursday, May 8 |
| » Defeated Angels (11-14), 9-2 | Anaheim Stadium (3-0) | 15-9 | Won 6 |
| » W: Paul Mirabella (3-1) L: Dave Frost (3-3) | First | -- |
| Saturday, May 10 |
| » Lost to Athletics (17-11), 4-3 | Oakland-Alameda County Stadium (0-1) | 15-10 | |
| » W: Rick Langford (3-1) L: Jerry Garvin (0-2) | First | -- |
| Sunday, May 11 |
| » Lost to Athletics (18-11), 12-1 | Oakland-Alameda County Stadium (0-2) | 15-11 | Lost 2 |
| » W: Mike Norris (5-0) L: Dave Lemanczyk (2-4) | Second | 1 out |
| Monday, May 12 |
| Future Blue Jay Felipe Lopez is born in Bayamon, P.R. |
| Wednesday, May 14 |
| » Lost to Mariners (16-16), 7-0 | Exhibition Stadium (6-4) | 15-12 | Lost 3 |
| » W: Glenn Abbott (3-2) L: Paul Mirabella (3-2) | Second | 1 out |
| Thursday, May 15 |
| » Defeated Mariners (16-17), 1-0 | Exhibition Stadium (7-4) | 16-12 | |
| » W: Jim Clancy (2-1) L: Floyd Bannister (2-3) | Second | ½ out |
| Friday, May 16 |
| » Defeated Athletics (18-14), 1-0 | Exhibition Stadium (8-4) | 17-12 | Won 2 |
| » W: Jesse Jefferson (2-1) L: Mike Norris (5-1) | Second | ½ out |
| Saturday, May 17 |
| » Lost to Athletics (19-14), 4-2 | Exhibition Stadium (8-5) | 17-13 | |
| » W: Matt Keough (5-3) L: Joey McLaughlin (1-2) | Second | 1½ out |
| Sunday, May 18 |
| » Defeated Athletics (19-15), 12-1 | Exhibition Stadium (9-5) | 18-13 | |
| » W: Paul Mirabella (4-2) L: Rick Langford (3-2) | Second | ½ out |
| Monday, May 19 |
| » Defeated Red Sox (17-18), 7-2 | Exhibition Stadium (10-5) | 19-13 | Won 2 |
| » W: Jim Clancy (3-1) L: Jack Billingham (1-1) | Second | ½ out |
| Tuesday, May 20 |
| » Lost to Red Sox (18-18), 4-3 | Exhibition Stadium (10-6) | 19-14 | |
| » W: Chuck Rainey (4-0) L: Dave Lemanczyk (2-5) S: Tom Burgmeier (7) | Second | ½ out |
| Wednesday, May 21 |
| » Lost to Red Sox (19-18), 11-2 | Exhibition Stadium (10-7) | 19-15 | Lost 2 |
| » W: Mike Torrez (1-4) L: Jesse Jefferson (2-2) | Second | 1½ out |
| Thursday, May 22 |
| » Lost to Yankees (22-14), 5-1 | Exhibition Stadium (10-8) | 19-16 | Lost 3 |
| » W: Mike Griffin (1-2) L: Dave Stieb (4-2) | Second | 2½ out |
| » Major-league debuts: Joe Lefebvre (Yankees) |
| Friday, May 23 |
| » Lost to Yankees (23-14), 7-3 | Exhibition Stadium (10-9) | 19-17 | Lost 4 |
| » W: Ron Guidry (5-0) L: Paul Mirabella (4-3) | Second | 3½ out |
| Saturday, May 24 |
| » Lost to Yankees (24-14), 6-2 | Exhibition Stadium (10-10) | 19-18 | Lost 5 |
| » W: Luis Tiant (3-2) L: Jim Clancy (3-2) S: Rudy May (3) | Second | 4½ out |
| » Major-league debuts: Lloyd Moseby (Blue Jays) |
| Sunday, May 25 |
| » Defeated Yankees (24-15), 9-6 | Exhibition Stadium (11-10) | 20-18 | |
| » W: Luis Leal (1-0) L: Tommy John (7-2) | Second | 3½ out |
| » Major-league debuts: Luis Leal (Blue Jays) |
| Monday, May 26 |
| » Defeated Red Sox (20-21), 3-1 | Fenway Park (1-0) | 21-18 | Won 2 |
| » W: Jerry Garvin (1-2) L: Dick Drago (2-2) | Second | 3½ out |
| Tuesday, May 27 |
| » Lost to Red Sox (21-21), 5-4 | Fenway Park (1-1) | 21-19 | |
| » W: Steve Renko (3-0) L: Tom Buskey (2-1) | Third | 4½ out |
| Wednesday, May 28 |
| » Defeated Red Sox (21-22), 4-1 | Fenway Park (2-1) | 22-19 | |
| » W: Dave Stieb (5-2) L: Bob Stanley (3-5) S: Joey McLaughlin (3) | Third | 3½ out |
| Friday, May 30 |
| » Lost to Yankees (27-16), 6-0 | Yankee Stadium (0-1) | 22-20 | |
| » W: Luis Tiant (4-2) L: Jim Clancy (3-3) S: Rich Gossage (5) | Second | 4½ out |
| Saturday, May 31 |
| » Lost to Yankees (28-16), 8-6 | Yankee Stadium (0-2) | 22-21 | Lost 2 |
| » W: Rudy May (3-1) L: Joey McLaughlin (1-3) | Third | 5½ out |
| Sunday, June 1 |
| » Lost to Yankees (29-16), 11-7 | Yankee Stadium (0-3) | 22-22 | Lost 3 |
| » W: Tom Underwood (5-3) L: Paul Mirabella (4-4) | Third | 6½ out |
| Monday, June 2 |
| » Lost to Angels (20-25), 6-3 | Exhibition Stadium (11-11) | 22-23 | Lost 4 |
| » W: Dave Frost (4-3) L: Luis Leal (1-1) S: Dave LaRoche (3) | Third | 7½ out |
| Tuesday, June 3 |
| » Defeated Angels (20-26), 7-6 | Exhibition Stadium (12-11) | 23-23 | |
| » W: Joey McLaughlin (2-3) L: Dave LaRoche (1-2) | Third | 6½ out |
| Wednesday, June 4 |
| » Defeated Angels (20-27), 8-2 | Exhibition Stadium (13-11) | 24-23 | Won 2 |
| » W: Jim Clancy (4-3) L: Alfredo Martinez (1-1) | Third | 5½ out |
| Friday, June 6 |
| » Lost to Twins (20-30), 5-0 | Metropolitan Stadium (0-1) | 24-24 | |
| » W: Geoff Zahn (4-7) L: Paul Mirabella (4-5) | Third | 6½ out |
| Saturday, June 7 |
| » Lost to Twins (21-30), 3-2 | Metropolitan Stadium (0-2) | 24-25 | Lost 2 |
| » W: Darrell Jackson (2-3) L: Dave Stieb (5-3) S: Doug Corbett (5) | Third | 7½ out |
| Sunday, June 8 |
| » Lost to Twins (22-30), 5-1 | Metropolitan Stadium (0-3) | 24-26 | Lost 3 |
| » W: Roger Erickson (1-3) L: Jesse Jefferson (2-3) S: Doug Corbett (6) | Fifth | 7 out |
| » Defeated Twins (22-31), 6-4 | Metropolitan Stadium (1-3) | 25-26 | |
| » W: Joey McLaughlin (3-3) L: Fernando Arroyo (0-1) | Fifth | 7 out |
| Tuesday, June 10 |
| » Defeated White Sox (28-26), 1-0 | Comiskey Park I (1-0) | 26-26 | Won 2 |
| » W: Jim Clancy (5-3) L: Ross Baumgarten (1-3) | Third | 6½ out |
| Wednesday, June 11 |
| » Lost to White Sox (29-26), 7-4 | Comiskey Park I (1-1) | 26-27 | |
| » W: Ken Kravec (3-4) L: Paul Mirabella (4-6) S: Ed Farmer (14) | Fourth | 7½ out |
| Friday, June 13 |
| » Lost to Rangers (26-31), 6-3 | Exhibition Stadium (13-12) | 26-28 | Lost 2 |
| » W: Doc Medich (6-3) L: Dave Stieb (5-4) S: Sparky Lyle (6) | Sixth | 8 out |
| Saturday, June 14 |
| » Defeated Rangers (26-32), 7-6 | Exhibition Stadium (14-12) | 27-28 | |
| » W: Tom Buskey (3-1) L: Bob Babcock (0-2) | Fifth | 8 out |
| Sunday, June 15 |
| » Defeated Rangers (26-33), 5-3 | Exhibition Stadium (15-12) | 28-28 | Won 2 |
| » W: Jim Clancy (6-3) L: Fergie Jenkins (4-5) S: Jerry Garvin (2) | Fifth | 8 out |
| Monday, June 16 |
| » Lost to Twins (24-36), 4-0 | Exhibition Stadium (15-13) | 28-29 | |
| » W: Geoff Zahn (5-9) L: Jesse Jefferson (2-4) | Sixth | 9 out |
| Tuesday, June 17 |
| » Lost to Twins (25-36), 8-6 | Exhibition Stadium (15-14) | 28-30 | Lost 2 |
| » W: Doug Corbett (4-2) L: Paul Mirabella (4-7) | Seventh | 10 out |
| Wednesday, June 18 |
| » Defeated White Sox (30-30), 5-4 | Exhibition Stadium (16-14) | 29-30 | |
| » W: Dave Stieb (6-4) L: Steve Trout (2-7) | Sixth | 9½ out |
| » Defeated White Sox (30-31), 3-1 | Exhibition Stadium (17-14) | 30-30 | Won 2 |
| » W: Jack Kucek (1-0) L: Richard Dotson (6-3) S: Joey McLaughlin (4) | Sixth | 9½ out |
| Friday, June 20 |
| » Lost to Rangers (29-35), 5-2 | Arlington Stadium (0-1) | 30-31 | |
| » W: Fergie Jenkins (5-5) L: Jerry Garvin (1-3) | Seventh | 11 out |
| Saturday, June 21 |
| » Lost to Rangers (30-35), 2-1 | Arlington Stadium (0-2) | 30-32 | Lost 2 |
| » W: Jon Matlack (4-3) L: Joey McLaughlin (3-4) | Seventh | 12 out |
| Sunday, June 22 |
| » Defeated Rangers (30-36), 6-5 | Arlington Stadium (1-2) | 31-32 | |
| » W: Jerry Garvin (2-3) L: Jim Kern (2-9) | Seventh | 11 out |
| Tuesday, June 24 |
| » Lost to Orioles (35-32), 1-0 | Memorial Stadium (0-1) | 31-33 | |
| » W: Scott McGregor (7-3) L: Dave Stieb (6-5) | Seventh | 11½ out |
| Wednesday, June 25 |
| » Lost to Orioles (36-32), 6-3 | Memorial Stadium (0-2) | 31-34 | Lost 2 |
| » W: Jim Palmer (7-4) L: Luis Leal (1-2) | Seventh | 11½ out |
| Thursday, June 26 |
| » Lost to Orioles (37-32), 4-1 | Memorial Stadium (0-3) | 31-35 | Lost 3 |
| » W: Steve Stone (10-3) L: Jim Clancy (6-4) | Seventh | 12 out |
| Friday, June 27 |
| » Lost to Tigers (36-30), 7-2 | Exhibition Stadium (17-15) | 31-36 | Lost 4 |
| » W: Jack Morris (9-6) L: Jesse Jefferson (2-5) | Seventh | 12 out |
| Saturday, June 28 |
| » Lost to Tigers (37-30), 8-3 | Exhibition Stadium (17-16) | 31-37 | Lost 5 |
| » W: Dave Rozema (4-4) L: Jack Kucek (1-1) | Seventh | 13 out |
| Sunday, June 29 |
| » Defeated Tigers (37-31), 2-0 | Exhibition Stadium (18-16) | 32-37 | |
| » W: Dave Stieb (7-5) L: Dan Petry (4-4) | Seventh | 13 out |
| Monday, June 30 |
| » Lost to Orioles (39-33), 9-7 | Exhibition Stadium (18-17) | 32-38 | |
| » W: Steve Stone (11-3) L: Luis Leal (1-3) | Seventh | 14 out |
| Tuesday, July 1 |
| » Lost to Orioles (40-33), 2-0 | Exhibition Stadium (18-18) | 32-39 | Lost 2 |
| » W: Jim Palmer (8-4) L: Jim Clancy (6-5) S: Tippy Martinez (4) | Seventh | 15 out |
| Wednesday, July 2 |
| » Lost to Orioles (41-33), 6-2 | Exhibition Stadium (18-19) | 32-40 | Lost 3 |
| » W: Mike Flanagan (8-6) L: Paul Mirabella (4-8) | Seventh | 16 out |
| Thursday, July 3 |
| » Lost to Tigers (40-32), 8-5 | Tiger Stadium (0-1) | 32-41 | Lost 4 |
| » W: Pat Underwood (2-5) L: Joey McLaughlin (3-5) | Seventh | 16 out |
| Friday, July 4 |
| » Lost to Tigers (41-32), 4-3 | Tiger Stadium (0-2) | 32-42 | Lost 5 |
| » W: Dan Petry (5-4) L: Dave Stieb (7-6) S: Aurelio Lopez (11) | Seventh | 17 out |
| Saturday, July 5 |
| » Defeated Tigers (41-33), 5-3 | Tiger Stadium (1-2) | 33-42 | |
| » W: Jim Clancy (7-5) L: Milt Wilcox (8-5) S: Jerry Garvin (3) | Seventh | 17 out |
| Sunday, July 6 |
| » Lost to Tigers (42-33), 7-5 | Tiger Stadium (1-3) | 33-43 | |
| » W: Jack Morris (11-6) L: Jerry Garvin (2-4) S: Aurelio Lopez (12) | Seventh | 17 out |
| Thursday, July 10 |
| » Lost to Indians (38-39), 7-3 | Exhibition Stadium (18-20) | 33-44 | Lost 2 |
| » W: John Denny (8-5) L: Jim Clancy (7-6) | Seventh | 18 out |
| Friday, July 11 |
| » Defeated Indians (38-40), 6-3 | Exhibition Stadium (19-20) | 34-44 | |
| » W: Dave Stieb (8-6) L: Wayne Garland (3-2) | Seventh | 17 out |
| Saturday, July 12 |
| » Lost to Brewers (46-35), 9-2 | Exhibition Stadium (19-21) | 34-45 | |
| » W: Bill Travers (9-3) L: Balor Moore (1-1) | Seventh | 18 out |
| Sunday, July 13 |
| » Defeated Brewers (46-36), 4-1 | Exhibition Stadium (20-21) | 35-45 | |
| » W: Jack Kucek (2-1) L: Moose Haas (9-8) S: Jerry Garvin (4) | Sixth | 18½ out |
| » Lost to Brewers (47-36), 4-0 | Exhibition Stadium (20-22) | 35-46 | |
| » W: Paul Mitchell (1-0) L: Joey McLaughlin (3-6) | Sixth | 18½ out |
| Monday, July 14 |
| » Lost to Brewers (48-36), 6-4 | Exhibition Stadium (20-23) | 35-47 | Lost 2 |
| » W: Jerry Augustine (2-2) L: Jim Clancy (7-7) S: Bill Castro (6) | Sixth | 19½ out |
| Wednesday, July 16 |
| » Defeated Mariners (36-50), 5-0 | Kingdome (2-3) | 36-47 | |
| » W: Dave Stieb (9-6) L: Glenn Abbott (7-5) | Seventh | 19 out |
| Thursday, July 17 |
| » Lost to Mariners (37-50), 5-3 | Kingdome (2-4) | 36-48 | |
| » W: Shane Rawley (5-3) L: Jesse Jefferson (2-6) | Seventh | 20 out |
| Friday, July 18 |
| » Lost to Angels (33-54), 6-3 | Anaheim Stadium (3-1) | 36-49 | Lost 2 |
| » W: Ed Halicki (3-1) L: Jack Kucek (2-2) S: Mark Clear (7) | Seventh | 20 out |
| Saturday, July 19 |
| » Defeated Angels (33-55), 5-4 | Anaheim Stadium (4-1) | 37-49 | |
| » W: Jim Clancy (8-7) L: John Montague (2-2) | Seventh | 20 out |
| Sunday, July 20 |
| » Defeated Angels (33-56), 6-3 | Anaheim Stadium (5-1) | 38-49 | Won 2 |
| » W: Joey McLaughlin (4-6) L: Mark Clear (6-6) | Seventh | 19 out |
| Monday, July 21 |
| » Defeated Athletics (44-49), 1-0 | Oakland-Alameda County Stadium (1-2) | 39-49 | Won 3 |
| » W: Dave Stieb (10-6) L: Brian Kingman (5-10) | Seventh | 18 out |
| Tuesday, July 22 |
| » Defeated Athletics (44-50), 6-2 | Oakland-Alameda County Stadium (2-2) | 40-49 | Won 4 |
| » W: Jesse Jefferson (3-6) L: Matt Keough (10-10) S: Jerry Garvin (5) | Seventh | 18 out |
| » Lost to Athletics (45-50), 5-1 | Oakland-Alameda County Stadium (2-3) | 40-50 | |
| » W: Mike Norris (13-6) L: Paul Mirabella (4-9) | Seventh | 18 out |
| Wednesday, July 23 |
| » Lost to Athletics (46-50), 6-2 | Oakland-Alameda County Stadium (2-4) | 40-51 | Lost 2 |
| » W: Steve McCatty (8-9) L: Jack Kucek (2-3) | Seventh | 19 out |
| Friday, July 25 |
| » Defeated Mariners (38-56), 5-3 | Exhibition Stadium (21-23) | 41-51 | |
| » W: Jim Clancy (9-7) L: Rick Honeycutt (8-9) | Seventh | 18 out |
| Saturday, July 26 |
| » Lost to Mariners (39-56), 7-2 | Exhibition Stadium (21-24) | 41-52 | |
| » W: Rob Dressler (1-4) L: Dave Stieb (10-7) | Seventh | 18½ out |
| » Defeated Mariners (39-57), 7-5 | Exhibition Stadium (22-24) | 42-52 | |
| » W: Jack Kucek (3-3) L: Glenn Abbott (8-6) S: Jerry Garvin (6) | Seventh | 18½ out |
| Sunday, July 27 |
| » Defeated Mariners (39-58), 5-0 | Exhibition Stadium (23-24) | 43-52 | Won 2 |
| » W: Jesse Jefferson (4-6) L: Floyd Bannister (6-9) | Seventh | 17½ out |
| Monday, July 28 |
| » Lost to Athletics (49-52), 5-3 | Exhibition Stadium (23-25) | 43-53 | |
| » W: Mike Norris (14-6) L: Mike Barlow (0-1) | Seventh | 18½ out |
| Tuesday, July 29 |
| » Lost to Athletics (50-52), 6-5 | Exhibition Stadium (23-26) | 43-54 | Lost 2 |
| » W: Bob Lacey (2-1) L: Jerry Garvin (2-5) | Seventh | 18½ out |
| Wednesday, July 30 |
| » Lost to Athletics (51-52), 11-1 | Exhibition Stadium (23-27) | 43-55 | Lost 3 |
| » W: Rick Langford (10-9) L: Dave Stieb (10-8) | Seventh | 18½ out |
| Friday, August 1 |
| » Defeated Angels (37-63), 9-8 | Exhibition Stadium (24-27) | 44-55 | |
| » W: Jerry Garvin (3-5) L: Mark Clear (7-9) | Seventh | 19 out |
| Saturday, August 2 |
| » Lost to Angels (38-63), 5-4 | Exhibition Stadium (24-28) | 44-56 | |
| » W: Dave LaRoche (2-2) L: Jesse Jefferson (4-7) | Seventh | 20 out |
| Sunday, August 3 |
| » Defeated Angels (38-64), 3-1 | Exhibition Stadium (25-28) | 45-56 | |
| » W: Jim Clancy (10-7) L: Alfredo Martinez (2-4) S: Mike Barlow (1) | Seventh | 19 out |
| Monday, August 4 |
| » Lost to Indians (51-49), 11-5 | Cleveland Stadium (1-2) | 45-57 | |
| » W: Dan Spillner (9-8) L: Paul Mirabella (4-10) S: Sid Monge (9) | Seventh | 20 out |
| Tuesday, August 5 |
| » Lost to Indians (52-49), 8-5 | Cleveland Stadium (1-3) | 45-58 | Lost 2 |
| » W: Ross Grimsley (5-4) L: Jack Kucek (3-4) S: Victor Cruz (6) | Seventh | 20 out |
| Wednesday, August 6 |
| » Lost to Indians (53-49), 5-2 | Cleveland Stadium (1-4) | 45-59 | Lost 3 |
| » W: Rick Waits (8-10) L: Jesse Jefferson (4-8) S: Victor Cruz (7) | Seventh | 21 out |
| Thursday, August 7 |
| » Lost to Indians (54-49), 7-6 | Cleveland Stadium (1-5) | 45-60 | Lost 4 |
| » W: Sid Monge (1-4) L: Jerry Garvin (3-6) | Seventh | 21½ out |
| Friday, August 8 |
| » Lost to Royals (68-40), 9-0 | Exhibition Stadium (25-29) | 45-61 | Lost 5 |
| » W: Rich Gale (10-7) L: Jim Clancy (10-8) | Seventh | 22 out |
| » Lost to Royals (69-40), 7-4 | Exhibition Stadium (25-30) | 45-62 | Lost 6 |
| » W: Marty Pattin (3-0) L: Jerry Garvin (3-7) | Seventh | 22 out |
| » Major-league debuts: Ken Schrom (Blue Jays) |
| Saturday, August 9 |
| » Defeated Royals (69-41), 4-3 | Exhibition Stadium (26-30) | 46-62 | |
| » W: Mike Willis (1-0) L: Rawly Eastwick (0-1) | Seventh | 21 out |
| Sunday, August 10 |
| » Lost to Royals (70-41), 8-5 | Exhibition Stadium (26-31) | 46-63 | |
| » W: Dennis Leonard (13-8) L: Jesse Jefferson (4-9) S: Marty Pattin (4) | Seventh | 21 out |
| Tuesday, August 12 |
| » Defeated Brewers (59-53), 3-1 | County Stadium (4-0) | 47-63 | |
| » W: Jim Clancy (11-8) L: Lary Sorensen (8-8) | Seventh | 21 out |
| » Defeated Brewers (59-54), 5-4 | County Stadium (5-0) | 48-63 | Won 2 |
| » W: Mike Barlow (1-1) L: Bill Castro (0-4) S: Jerry Garvin (7) | Seventh | 21 out |
| Wednesday, August 13 |
| » Lost to Brewers (60-54), 5-4 | County Stadium (5-1) | 48-64 | |
| » W: Bill Travers (11-5) L: Joey McLaughlin (4-7) | Seventh | 21 out |
| Thursday, August 14 |
| » Lost to Brewers (61-54), 4-2 | County Stadium (5-2) | 48-65 | Lost 2 |
| » W: Moose Haas (14-9) L: Dave Stieb (10-9) | Seventh | 21 out |
| Friday, August 15 |
| » Lost to Royals (73-42), 4-3 | Royals Stadium (1-3) | 48-66 | Lost 3 |
| » W: Dennis Leonard (14-8) L: Jesse Jefferson (4-10) S: Dan Quisenberry (24) | Seventh | 22 out |
| Saturday, August 16 |
| » Lost to Royals (74-42), 11-5 | Royals Stadium (1-4) | 48-67 | Lost 4 |
| » W: Larry Gura (17-5) L: Jack Kucek (3-5) | Seventh | 23 out |
| Sunday, August 17 |
| » Lost to Royals (75-42), 8-3 | Royals Stadium (1-5) | 48-68 | Lost 5 |
| » W: Paul Splittorff (9-8) L: Jim Clancy (11-9) S: Dan Quisenberry (25) | Seventh | 23 out |
| Tuesday, August 19 |
| » Defeated Twins (52-67), 4-3 | Metropolitan Stadium (2-3) | 49-68 | |
| » W: Mike Barlow (2-1) L: Doug Corbett (8-5) S: Ken Schrom (1) | Seventh | 22½ out |
| Wednesday, August 20 |
| » Defeated Twins (52-68), 10-4 | Metropolitan Stadium (3-3) | 50-68 | Won 2 |
| » W: Jackson Todd (1-0) L: Geoff Zahn (10-16) | Seventh | 22½ out |
| Thursday, August 21 |
| » Lost to White Sox (50-68), 5-3 | Comiskey Park I (1-2) | 50-69 | |
| » W: La Marr Hoyt (5-2) L: Jesse Jefferson (4-11) S: Ed Farmer (21) | Sixth | 22½ out |
| Friday, August 22 |
| » Lost to White Sox (51-68), 2-0 | Comiskey Park I (1-3) | 50-70 | Lost 2 |
| » W: Britt Burns (11-12) L: Jim Clancy (11-10) S: Ed Farmer (22) | Seventh | 22½ out |
| Saturday, August 23 |
| » Lost to White Sox (52-68), 5-1 | Comiskey Park I (1-4) | 50-71 | Lost 3 |
| » W: Richard Dotson (10-8) L: Jack Kucek (3-6) | Sixth | 23½ out |
| Sunday, August 24 |
| » Defeated White Sox (52-69), 7-3 | Comiskey Park I (2-4) | 51-71 | |
| » W: Dave Stieb (11-9) L: Ross Baumgarten (2-8) S: Mike Barlow (2) | Seventh | 23½ out |
| Monday, August 25 |
| » Lost to Rangers (61-63), 5-1 | Exhibition Stadium (26-32) | 51-72 | |
| » W: Ken Clay (2-0) L: Jackson Todd (1-1) S: John Henry Johnson (2) | Seventh | 23½ out |
| Tuesday, August 26 |
| » Lost to Rangers (62-63), 8-0 | Exhibition Stadium (26-33) | 51-73 | Lost 2 |
| » W: Charlie Hough (3-4) L: Jesse Jefferson (4-12) | Seventh | 23½ out |
| Wednesday, August 27 |
| » Defeated Rangers (62-64), 6-4 | Exhibition Stadium (27-33) | 52-73 | |
| » W: Jim Clancy (12-10) L: Doc Medich (10-9) S: Jerry Garvin (8) | Seventh | 23 out |
| Thursday, August 28 |
| » Game at Exhibition Stadium interrupted in the 15th inning with the score of Twins 5, Blue Jays 5. Completed on August 29. |
| Friday, August 29 |
| » Lost to Twins (56-73), 5-2 | Exhibition Stadium (27-34) | 52-74 | |
| » W: Geoff Zahn (11-17) L: Dave Stieb (11-10) | Seventh | 25 out |
| » Lost to Twins (57-73), 7-5 | Exhibition Stadium (27-35) | 52-75 | Lost 2 |
| » W: John Verhoeven (2-3) L: Jesse Jefferson (4-13) S: Albert Williams (1) | Seventh | 25 out |
| Saturday, August 30 |
| » Defeated Twins (57-74), 3-2 | Exhibition Stadium (28-35) | 53-75 | |
| » W: Jackson Todd (2-1) L: John Verhoeven (2-4) | Sixth | 25 out |
| Future Blue Jay Russ Adams is born in Laurinburg, NC. |
| Sunday, August 31 |
| » Defeated Twins (57-75), 7-1 | Exhibition Stadium (29-35) | 54-75 | Won 2 |
| » W: Jim Clancy (13-10) L: Jerry Koosman (11-12) | Seventh | 24 out |
| Monday, September 1 |
| » Lost to Rangers (65-66), 9-1 | Arlington Stadium (1-3) | 54-76 | |
| » W: Doc Medich (11-9) L: Joey McLaughlin (4-8) | Seventh | 25 out |
| Tuesday, September 2 |
| » Lost to Rangers (66-66), 3-2 | Arlington Stadium (1-4) | 54-77 | Lost 2 |
| » W: Fergie Jenkins (12-10) L: Luis Leal (1-4) | Seventh | 26 out |
| Wednesday, September 3 |
| » Defeated Rangers (66-67), 4-2 | Arlington Stadium (2-4) | 55-77 | |
| » W: Dave Stieb (12-10) L: Ed Figueroa (3-9) | Seventh | 26 out |
| Thursday, September 4 |
| » Defeated White Sox (56-76), 3-2 | Exhibition Stadium (30-35) | 56-77 | Won 2 |
| » W: Jackson Todd (3-1) L: Ed Farmer (6-8) | Seventh | 26 out |
| Friday, September 5 |
| » Lost to White Sox (57-76), 3-0 | Exhibition Stadium (30-36) | 56-78 | |
| » W: La Marr Hoyt (7-2) L: Jim Clancy (13-11) | Seventh | 27 out |
| Sunday, September 7 |
| » Defeated White Sox (57-77), 3-1 | Exhibition Stadium (31-36) | 57-78 | |
| » W: Joey McLaughlin (5-8) L: Steve Trout (8-13) S: Mike Barlow (3) | Seventh | 27 out |
| » Defeated White Sox (57-78), 7-6 | Exhibition Stadium (32-36) | 58-78 | Won 2 |
| » W: Ken Schrom (1-0) L: Mike Proly (3-9) S: Mike Barlow (4) | Seventh | 27 out |
| Monday, September 8 |
| » Lost to Yankees (86-51), 7-4 | Exhibition Stadium (32-37) | 58-79 | |
| » W: Tommy John (20-7) L: Dave Stieb (12-11) S: Rich Gossage (25) | Seventh | 28 out |
| Tuesday, September 9 |
| » Defeated Yankees (86-52), 6-4 | Exhibition Stadium (33-37) | 59-79 | |
| » W: Jackson Todd (4-1) L: Gaylord Perry (9-11) S: Mike Willis (1) | Seventh | 27 out |
| Wednesday, September 10 |
| » Lost to Yankees (87-52), 7-6 | Exhibition Stadium (33-38) | 59-80 | |
| » W: Ron Davis (6-3) L: Jim Clancy (13-12) S: Rich Gossage (26) | Seventh | 28 out |
| Thursday, September 11 |
| » Lost to Orioles (85-55), 6-1 | Exhibition Stadium (33-39) | 59-81 | Lost 2 |
| » W: Steve Stone (23-6) L: Paul Mirabella (4-11) | Seventh | 29 out |
| Friday, September 12 |
| » Defeated Orioles (85-56), 7-5 | Exhibition Stadium (34-39) | 60-81 | |
| » W: Joey McLaughlin (6-8) L: Mike Flanagan (14-12) S: Mike Willis (2) | Seventh | 29 out |
| Saturday, September 13 |
| » Lost to Orioles (86-56), 6-4 | Exhibition Stadium (34-40) | 60-82 | |
| » W: Scott McGregor (18-7) L: Dave Stieb (12-12) S: Tim Stoddard (22) | Seventh | 30 out |
| Sunday, September 14 |
| » Defeated Orioles (86-57), 4-3 | Exhibition Stadium (35-40) | 61-82 | |
| » W: Mike Barlow (3-1) L: Dennis Martinez (5-4) | Seventh | 30 out |
| Tuesday, September 16 |
| » Lost to Yankees (92-52), 5-4 | Yankee Stadium (0-4) | 61-83 | |
| » W: Ron Guidry (14-10) L: Jim Clancy (13-13) S: Rich Gossage (28) | Seventh | 31 out |
| Wednesday, September 17 |
| » Game at Yankee Stadium interrupted in the 10th inning with the score of Blue Jays 5, Yankees 3. Completed on September 18. |
| Thursday, September 18 |
| » Defeated Yankees (92-53), 2-1 | Yankee Stadium (1-4) | 62-83 | |
| » W: Luis Leal (2-4) L: Tommy John (21-8) | Seventh | 31 out |
| » Lost to Yankees (93-53), 8-7 | Yankee Stadium (1-5) | 62-84 | |
| » W: Tom Underwood (13-9) L: Jack Kucek (3-7) | Seventh | 31 out |
| Friday, September 19 |
| » Lost to Orioles (89-58), 8-6 | Memorial Stadium (0-4) | 62-85 | Lost 2 |
| » W: Tippy Martinez (3-3) L: Mike Willis (1-1) | Seventh | 32 out |
| Saturday, September 20 |
| » Lost to Orioles (90-58), 6-1 | Memorial Stadium (0-5) | 62-86 | Lost 3 |
| » W: Steve Stone (24-7) L: Dave Stieb (12-13) | Seventh | 32 out |
| Sunday, September 21 |
| » Lost to Orioles (91-58), 2-1 | Memorial Stadium (0-6) | 62-87 | Lost 4 |
| » W: Mike Flanagan (15-12) L: Jim Clancy (13-14) S: Tim Stoddard (24) | Seventh | 33 out |
| Monday, September 22 |
| » Defeated Tigers (77-73), 6-5 | Tiger Stadium (2-3) | 63-87 | |
| » W: Jerry Garvin (4-7) L: Roger Weaver (2-3) S: Mike Willis (3) | Seventh | 33 out |
| Tuesday, September 23 |
| » Defeated Tigers (77-74), 9-7 | Tiger Stadium (3-3) | 64-87 | Won 2 |
| » W: Mike Willis (2-1) L: Dave Rozema (6-9) S: Jack Kucek (1) | Seventh | 33 out |
| Wednesday, September 24 |
| » Lost to Tigers (78-74), 9-8 | Tiger Stadium (3-4) | 64-88 | |
| » W: Dan Petry (10-9) L: Jack Kucek (3-8) | Seventh | 34 out |
| Friday, September 26 |
| » Lost to Red Sox (80-70), 3-1 | Exhibition Stadium (35-41) | 64-89 | Lost 2 |
| » W: Dennis Eckersley (12-13) L: Dave Stieb (12-14) | Seventh | 34½ out |
| Saturday, September 27 |
| » Lost to Red Sox (81-70), 4-3 | Exhibition Stadium (35-42) | 64-90 | Lost 3 |
| » W: Bob Stanley (10-7) L: Jim Clancy (13-15) S: Tom Burgmeier (24) | Seventh | 34½ out |
