| Sunday, January 28 |
| Future Red Sox Phil Seibel is born in Louisville, KY. |
| Thursday, February 8 |
| Former Red Sox Alex Gaston dies in Santa Monica, CA at the age of 86. |
| Friday, March 2 |
| Former Red Sox Dale Alexander dies in Greeneville, TN at the age of 76. |
| Thursday, March 15 |
| Future Red Sox Kevin Youkilis is born in Cincinnati, OH. |
| Wednesday, April 4 |
| » Major-league debuts: Mark Clear (Angels) |
| Thursday, April 5 |
| » Defeated Indians (0-1), 7-1 | Fenway Park (1-0) | 1-0 | |
| » W: Dennis Eckersley (1-0) L: Rick Wise (0-1) | First | -- |
| Friday, April 6 |
| Former Red Sox Al Evans dies in Wilson, NC at the age of 63. Former Red Sox Rudy Kallio dies in Newport, OR at the age of 87. |
| Saturday, April 7 |
| » Lost to Indians (1-1), 3-0 | Cleveland Stadium (0-1) | 1-1 | |
| » W: Rick Waits (1-0) L: Mike Torrez (0-1) | Second | 1 out |
| Sunday, April 8 |
| » Defeated Indians (1-2), 7-6 | Cleveland Stadium (1-1) | 2-1 | |
| » W: Dick Drago (1-0) L: Victor Cruz (0-1) | First | -- |
| » Major-league debuts: Gary Allenson, Mike O'Berry and Chuck Rainey (Red Sox) |
| Tuesday, April 10 |
| » Lost to Brewers (3-1), 3-0 | County Stadium (0-1) | 2-2 | |
| » W: Mike Caldwell (2-0) L: Dennis Eckersley (1-1) | Third | 1 out |
| Thursday, April 12 |
| » Defeated Brewers (3-2), 12-10 | County Stadium (1-1) | 3-2 | |
| » W: Dick Drago (2-0) L: Reggie Cleveland (0-1) S: Bob Stanley (1) | First | -- |
| Sunday, April 15 |
| » Defeated Indians (1-6), 14-4 | Fenway Park (2-0) | 4-2 | Won 2 |
| » W: Dennis Eckersley (2-1) L: Mike Paxton (0-1) S: Dick Drago (1) | Second | 1 out |
| Monday, April 16 |
| » Lost to Indians (2-6), 4-3 | Fenway Park (2-1) | 4-3 | |
| » W: Rick Wise (1-2) L: Bob Stanley (0-1) S: Victor Cruz (1) | Second | 1½ out |
| Tuesday, April 17 |
| » Defeated Brewers (6-3), 6-5 | Fenway Park (3-1) | 5-3 | |
| » W: Tom Burgmeier (1-0) L: Reggie Cleveland (0-2) | Second | ½ out |
| Wednesday, April 18 |
| » Lost to Brewers (7-3), 4-1 | Fenway Park (3-2) | 5-4 | |
| » W: Lary Sorensen (2-1) L: Steve Renko (0-1) | Third | 1½ out |
| Thursday, April 19 |
| » Defeated Brewers (7-4), 5-3 | Fenway Park (4-2) | 6-4 | |
| » W: Chuck Rainey (1-0) L: Jim Slaton (0-1) S: Dick Drago (2) | Second | ½ out |
| Friday, April 20 |
| » Defeated Royals (5-6), 9-2 | Fenway Park (5-2) | 7-4 | Won 2 |
| » W: Andy Hassler (1-0) L: Dennis Leonard (1-2) | First | -- |
| Saturday, April 21 |
| » Defeated Royals (5-7), 10-4 | Fenway Park (6-2) | 8-4 | Won 3 |
| » W: Bob Stanley (1-1) L: Larry Gura (1-2) S: Tom Burgmeier (1) | First | -- |
| Sunday, April 22 |
| » Defeated Royals (5-8), 6-0 | Fenway Park (7-2) | 9-4 | Won 4 |
| » W: Mike Torrez (1-1) L: Rich Gale (0-2) | First | -- |
| Tuesday, April 24 |
| » Defeated Mariners (5-12), 4-3 | Kingdome (1-0) | 10-4 | Won 5 |
| » W: Dick Drago (3-0) L: Shane Rawley (0-3) S: Bill Campbell (1) | First | -- |
| Wednesday, April 25 |
| » Defeated Mariners (5-13), 4-1 | Kingdome (2-0) | 11-4 | Won 6 |
| » W: Jim Wright (1-0) L: Floyd Bannister (1-3) S: Chuck Rainey (1) | First | -- |
| Thursday, April 26 |
| » Defeated Mariners (5-14), 2-0 | Kingdome (3-0) | 12-4 | Won 7 |
| » W: Bob Stanley (2-1) L: Paul Mitchell (0-2) | First | -- |
| Friday, April 27 |
| » Lost to Angels (13-7), 8-6 | Anaheim Stadium (0-1) | 12-5 | |
| » W: Mark Clear (2-0) L: Andy Hassler (1-1) | First | -- |
| Saturday, April 28 |
| » Lost to Angels (14-7), 5-0 | Anaheim Stadium (0-2) | 12-6 | Lost 2 |
| » W: Dave Frost (2-0) L: Chuck Rainey (1-1) | First | -- |
| Sunday, April 29 |
| » Defeated Angels (14-8), 2-0 | Anaheim Stadium (1-2) | 13-6 | |
| » W: Steve Renko (1-1) L: Don Aase (2-2) S: Bill Campbell (2) | First | -- |
| Monday, April 30 |
| » Lost to Athletics (8-14), 5-4 | Oakland-Alameda County Stadium (0-1) | 13-7 | |
| » W: Bob Lacey (1-1) L: Dick Drago (3-1) | First | -- |
| Tuesday, May 1 |
| » Lost to Athletics (9-14), 7-5 | Oakland-Alameda County Stadium (0-2) | 13-8 | Lost 2 |
| » W: Steve McCatty (1-0) L: Bob Stanley (2-2) S: Bob Lacey (2) | Second | 1½ out |
| Wednesday, May 2 |
| » Defeated Athletics (9-15), 2-1 | Oakland-Alameda County Stadium (1-2) | 14-8 | |
| » W: Mike Torrez (2-1) L: Matt Keough (0-4) | Second | 1½ out |
| Thursday, May 3 |
| Former Red Sox Tom Jenkins dies in Weymouth, MA at the age of 82. |
| Friday, May 4 |
| » Defeated Mariners (8-18), 5-3 | Fenway Park (8-2) | 15-8 | Won 2 |
| » W: Steve Renko (2-1) L: Glenn Abbott (1-3) | First | -- |
| Saturday, May 5 |
| » Defeated Mariners (8-19), 11-4 | Fenway Park (9-2) | 16-8 | Won 3 |
| » W: Dennis Eckersley (3-1) L: Odell Jones (0-2) S: Dick Drago (3) | First | -- |
| Sunday, May 6 |
| » Lost to Mariners (9-19), 3-2 | Fenway Park (9-3) | 16-9 | |
| » W: John Montague (3-0) L: Bill Campbell (0-1) | Second | 1 out |
| Monday, May 7 |
| » Defeated Angels (16-12), 9-4 | Fenway Park (10-3) | 17-9 | |
| » W: Mike Torrez (3-1) L: Nolan Ryan (4-2) | First | -- |
| Former Red Sox Marty McHale dies in Hempstead, NY at the age of 93. |
| Tuesday, May 8 |
| » Lost to Angels (17-12), 10-2 | Fenway Park (10-4) | 17-10 | |
| » W: Chris Knapp (2-0) L: Chuck Rainey (1-2) | Second | 1 out |
| Wednesday, May 9 |
| » Defeated Angels (17-13), 9-8 | Fenway Park (11-4) | 18-10 | |
| » W: Bill Campbell (1-1) L: Dave LaRoche (2-4) | First | -- |
| Thursday, May 10 |
| » Lost to Angels (18-13), 5-3 | Fenway Park (11-5) | 18-11 | |
| » W: Don Aase (3-3) L: Dennis Eckersley (3-2) S: Mark Clear (2) | Second | 1 out |
| Friday, May 11 |
| » Defeated Athletics (12-20), 11-2 | Fenway Park (12-5) | 19-11 | |
| » W: Bob Stanley (3-2) L: Matt Keough (0-5) | Second | 1 out |
| Saturday, May 12 |
| » Defeated Athletics (12-21), 8-2 | Fenway Park (13-5) | 20-11 | Won 2 |
| » W: Mike Torrez (4-1) L: Rick Langford (1-5) | Second | 1 out |
| Sunday, May 13 |
| » Defeated Athletics (12-22), 8-2 | Fenway Park (14-5) | 21-11 | Won 3 |
| » W: Chuck Rainey (2-2) L: Mike Norris (3-2) | Second | ½ out |
| Tuesday, May 15 |
| » Defeated Orioles (22-12), 3-2 | Fenway Park (15-5) | 22-11 | Won 4 |
| » W: Dennis Eckersley (4-2) L: Don Stanhouse (2-1) | First | -- |
| Wednesday, May 16 |
| » Lost to Orioles (23-12), 10-6 | Fenway Park (15-6) | 22-12 | |
| » W: Dennis Martinez (5-2) L: Andy Hassler (1-2) S: Tim Stoddard (1) | Second | ½ out |
| Thursday, May 17 |
| » Defeated Orioles (23-13), 6-2 | Fenway Park (16-6) | 23-12 | |
| » W: Bob Stanley (4-2) L: Steve Stone (3-2) S: Dick Drago (4) | First | -- |
| Friday, May 18 |
| » Lost to Yankees (21-16), 10-0 | Fenway Park (16-7) | 23-13 | |
| » W: Jim Beattie (3-1) L: Mike Torrez (4-2) | Second | ½ out |
| Saturday, May 19 |
| » Defeated Yankees (21-17), 4-3 | Fenway Park (17-7) | 24-13 | |
| » W: Bill Campbell (2-1) L: Ed Figueroa (3-5) S: Dick Drago (5) | Second | ½ out |
| Sunday, May 20 |
| » Lost to Yankees (22-17), 2-0 | Fenway Park (17-8) | 24-14 | |
| » W: Tommy John (9-0) L: Dennis Eckersley (4-3) | Second | 1½ out |
| Tuesday, May 22 |
| » Defeated Orioles (26-14), 7-5 | Memorial Stadium (1-0) | 25-14 | |
| » W: Steve Renko (3-1) L: Mike Flanagan (6-3) S: Bill Campbell (3) | Second | ½ out |
| Wednesday, May 23 |
| » Lost to Orioles (27-14), 5-2 | Memorial Stadium (1-1) | 25-15 | |
| » W: Tippy Martinez (2-1) L: Bob Stanley (4-3) | Second | 1½ out |
| Thursday, May 24 |
| » Lost to Orioles (28-14), 5-3 | Memorial Stadium (1-2) | 25-16 | Lost 2 |
| » W: Dennis Martinez (7-2) L: Mike Torrez (4-3) | Second | 2½ out |
| Saturday, May 26 |
| » Lost to Blue Jays (12-33), 7-6 | Exhibition Stadium (0-1) | 25-17 | Lost 3 |
| » W: Tom Buskey (1-0) L: Bill Campbell (2-2) | Second | 3½ out |
| Sunday, May 27 |
| » Defeated Blue Jays (12-34), 1-0 | Exhibition Stadium (1-1) | 26-17 | |
| » W: Chuck Rainey (3-2) L: Jesse Jefferson (0-4) | Second | 2 out |
| Monday, May 28 |
| » Lost to Rangers (27-19), 5-2 | Arlington Stadium (0-1) | 26-18 | |
| » W: Fergie Jenkins (6-2) L: Steve Renko (3-2) S: Sparky Lyle (7) | Second | 2 out |
| Wednesday, May 30 |
| » Lost to Rangers (28-19), 3-2 | Arlington Stadium (0-2) | 26-19 | Lost 2 |
| » W: Jim Kern (7-0) L: Dick Drago (3-2) | Second | 2½ out |
| Thursday, May 31 |
| » Defeated Rangers (28-20), 3-2 | Arlington Stadium (1-2) | 27-19 | |
| » W: Dick Drago (4-2) L: Sparky Lyle (3-4) | Second | 2 out |
| Friday, June 1 |
| » Defeated Twins (27-20), 5-2 | Metropolitan Stadium (1-0) | 28-19 | Won 2 |
| » W: Bob Stanley (5-3) L: Jerry Koosman (7-3) S: Bill Campbell (4) | Second | 1 out |
| Saturday, June 2 |
| » Lost to Twins (28-20), 8-2 | Metropolitan Stadium (1-1) | 28-20 | |
| » W: Dave Goltz (5-5) L: Chuck Rainey (3-3) | Second | 2 out |
| Sunday, June 3 |
| » Defeated Twins (28-21), 8-2 | Metropolitan Stadium (2-1) | 29-20 | |
| » W: Steve Renko (4-2) L: Geoff Zahn (3-1) S: Bill Campbell (5) | Second | 1 out |
| Monday, June 4 |
| » Defeated Rangers (30-22), 13-5 | Fenway Park (18-8) | 30-20 | Won 2 |
| » W: Mike Torrez (5-3) L: Dock Ellis (1-4) | Second | 1 out |
| Tuesday, June 5 |
| » Defeated Rangers (30-23), 9-3 | Fenway Park (19-8) | 31-20 | Won 3 |
| » W: Dennis Eckersley (5-3) L: Jon Matlack (3-3) | First | -- |
| Wednesday, June 6 |
| » Lost to White Sox (26-28), 8-5 | Fenway Park (19-9) | 31-21 | |
| » W: Francisco Barrios (5-3) L: Bob Stanley (5-4) S: Steve Trout (2) | Second | 1 out |
| Thursday, June 7 |
| » Defeated White Sox (26-29), 9-2 | Fenway Park (20-9) | 32-21 | |
| » W: Chuck Rainey (4-3) L: Ken Kravec (6-4) | Second | 1 out |
| Friday, June 8 |
| » Defeated Twins (30-24), 2-1 | Fenway Park (21-9) | 33-21 | Won 2 |
| » W: Bob Stanley (6-4) L: Dave Goltz (5-6) | Second | 1 out |
| Saturday, June 9 |
| » Defeated Twins (30-25), 12-6 | Fenway Park (22-9) | 34-21 | Won 3 |
| » W: Mike Torrez (6-3) L: Roger Erickson (0-6) | Second | 1 out |
| Sunday, June 10 |
| » Defeated Twins (30-26), 5-0 | Fenway Park (23-9) | 35-21 | Won 4 |
| » W: Dennis Eckersley (6-3) L: Paul Hartzell (3-4) | Second | 1 out |
| Monday, June 11 |
| » Defeated Royals (32-28), 4-0 | Royals Stadium (1-0) | 36-21 | Won 5 |
| » W: Bob Stanley (7-4) L: Steve Busby (2-3) | Second | 1 out |
| Tuesday, June 12 |
| » Lost to Royals (33-28), 7-6 | Royals Stadium (1-1) | 36-22 | |
| » W: Al Hrabosky (4-2) L: Dick Drago (4-3) | Second | 1 out |
| Wednesday, June 13 |
| » Defeated Royals (33-29), 11-3 | Royals Stadium (2-1) | 37-22 | |
| » W: Steve Renko (5-2) L: Larry Gura (3-6) | Second | 1 out |
| Friday, June 15 |
| » Lost to White Sox (30-31), 8-5 | Comiskey Park I (0-1) | 37-23 | |
| » W: Rich Wortham (7-5) L: Mike Torrez (6-4) | Second | 2 out |
| Saturday, June 16 |
| » Defeated White Sox (30-32), 11-5 | Comiskey Park I (1-1) | 38-23 | |
| » W: Dennis Eckersley (7-3) L: Randy Scarbery (1-3) | Second | 1½ out |
| Sunday, June 17 |
| » Lost to White Sox (31-32), 6-1 | Comiskey Park I (1-2) | 38-24 | |
| » W: Ken Kravec (8-4) L: Chuck Rainey (4-4) | Second | 2½ out |
| Former Red Sox Duffy Lewis dies in Salem, NH at the age of 92. |
| Monday, June 18 |
| » Defeated Tigers (30-30), 9-8 | Fenway Park (24-9) | 39-24 | |
| » W: Dick Drago (5-3) L: Fernando Arroyo (1-1) S: Bill Campbell (6) | Second | 2½ out |
| Tuesday, June 19 |
| » Lost to Tigers (31-30), 10-4 | Fenway Park (24-10) | 39-25 | |
| » W: Aurelio Lopez (2-1) L: Bob Stanley (7-5) | Second | 3½ out |
| Wednesday, June 20 |
| » Defeated Tigers (31-31), 13-3 | Fenway Park (25-10) | 40-25 | |
| » W: Mike Torrez (7-4) L: Steve Baker (1-4) | Second | 3½ out |
| Thursday, June 21 |
| » Defeated Tigers (31-32), 3-2 | Fenway Park (26-10) | 41-25 | Won 2 |
| » W: Dennis Eckersley (8-3) L: Jack Morris (4-4) | Second | 3 out |
| Friday, June 22 |
| » Defeated Blue Jays (23-49), 12-1 | Fenway Park (27-10) | 42-25 | Won 3 |
| » W: Chuck Rainey (5-4) L: Jesse Jefferson (1-7) S: Tom Burgmeier (2) | Second | 3 out |
| Saturday, June 23 |
| » Defeated Blue Jays (23-50), 4-3 | Fenway Park (28-10) | 43-25 | Won 4 |
| » W: Dick Drago (6-3) L: Tom Buskey (3-2) | Second | 3½ out |
| Sunday, June 24 |
| » Defeated Blue Jays (23-51), 8-4 | Fenway Park (29-10) | 44-25 | Won 5 |
| » W: Mike Torrez (8-4) L: Phil Huffman (4-8) | Second | 2½ out |
| Tuesday, June 26 |
| » Lost to Tigers (33-35), 6-4 | Tiger Stadium (0-1) | 44-26 | |
| » W: Jack Morris (5-4) L: Bill Campbell (2-3) | Second | 4 out |
| Wednesday, June 27 |
| » Defeated Tigers (33-36), 3-1 | Tiger Stadium (1-1) | 45-26 | |
| » W: Bob Stanley (8-5) L: Dave Tobik (1-3) | Second | 4 out |
| Thursday, June 28 |
| » Lost to Tigers (34-36), 6-3 | Tiger Stadium (1-2) | 45-27 | |
| » W: Jack Billingham (7-4) L: Steve Renko (5-3) S: Aurelio Lopez (1) | Second | 4 out |
| Friday, June 29 |
| » Defeated Yankees (41-35), 3-2 | Yankee Stadium (1-0) | 46-27 | |
| » W: Dick Drago (7-3) L: Jim Kaat (2-1) | Second | 4½ out |
| Saturday, June 30 |
| » Defeated Yankees (41-36), 3-2 | Yankee Stadium (2-0) | 47-27 | Won 2 |
| » W: Bob Stanley (9-5) L: Luis Tiant (4-3) | Second | 4½ out |
| Sunday, July 1 |
| » Lost to Yankees (42-36), 6-5 | Yankee Stadium (2-1) | 47-28 | |
| » W: Ron Davis (7-0) L: Dennis Eckersley (8-4) S: Jim Kaat (1) | Second | 5½ out |
| Monday, July 2 |
| » Lost to Yankees (43-36), 7-2 | Yankee Stadium (2-2) | 47-29 | Lost 2 |
| » W: Tommy John (12-3) L: Joel Finch (0-1) | Second | 5½ out |
| Tuesday, July 3 |
| » Defeated Royals (42-37), 10-0 | Fenway Park (30-10) | 48-29 | |
| » W: Steve Renko (6-3) L: Steve Busby (3-6) | Second | 4½ out |
| Wednesday, July 4 |
| » Defeated Royals (42-38), 6-4 | Fenway Park (31-10) | 49-29 | Won 2 |
| » W: Mike Torrez (9-4) L: Al Hrabosky (6-4) | Second | 3½ out |
| Thursday, July 5 |
| » Defeated Royals (42-39), 5-4 | Fenway Park (32-10) | 50-29 | Won 3 |
| » W: Bob Stanley (10-5) L: Bill Paschall (0-1) | Second | 3 out |
| Friday, July 6 |
| » Lost to Mariners (37-49), 5-3 | Kingdome (3-1) | 50-30 | |
| » W: Floyd Bannister (4-7) L: Dennis Eckersley (8-5) S: Byron McLaughlin (6) | Second | 3 out |
| Saturday, July 7 |
| » Defeated Mariners (37-50), 10-8 | Kingdome (4-1) | 51-30 | |
| » W: Tom Burgmeier (2-0) L: Mike Parrott (6-5) S: Allen Ripley (1) | Second | 2 out |
| Sunday, July 8 |
| » Defeated Mariners (37-51), 8-2 | Kingdome (5-1) | 52-30 | Won 2 |
| » W: Steve Renko (7-3) L: Byron McLaughlin (5-3) | Second | 2 out |
| Monday, July 9 |
| » Lost to Angels (51-37), 6-0 | Anaheim Stadium (1-3) | 52-31 | |
| » W: Nolan Ryan (11-6) L: Mike Torrez (9-5) | Second | 3 out |
| Tuesday, July 10 |
| » Lost to Angels (52-37), 4-3 | Anaheim Stadium (1-4) | 52-32 | Lost 2 |
| » W: Jim Barr (6-4) L: Bob Stanley (10-6) S: Mark Clear (8) | Second | 3 out |
| Wednesday, July 11 |
| » Defeated Angels (52-38), 9-3 | Anaheim Stadium (2-4) | 53-32 | |
| » W: Dennis Eckersley (9-5) L: Dave Frost (7-5) | Second | 3 out |
| Thursday, July 12 |
| Future Red Sox Adam Johnson is born in San Jose, CA. |
| Friday, July 13 |
| » Defeated Athletics (25-67), 2-0 | Oakland-Alameda County Stadium (2-2) | 54-32 | Won 2 |
| » W: Steve Renko (8-3) L: Mike Morgan (0-4) S: Bill Campbell (7) | Second | 2 out |
| Saturday, July 14 |
| » Defeated Athletics (25-68), 8-7 | Oakland-Alameda County Stadium (3-2) | 55-32 | Won 3 |
| » W: Allen Ripley (1-0) L: Steve McCatty (5-5) S: Bill Campbell (8) | Second | 2 out |
| Sunday, July 15 |
| » Defeated Athletics (25-69), 3-2 | Oakland-Alameda County Stadium (4-2) | 56-32 | Won 4 |
| » W: Bob Stanley (11-6) L: Rick Langford (5-10) | Second | 2 out |
| Thursday, July 19 |
| » Defeated Mariners (40-55), 7-1 | Fenway Park (33-10) | 57-32 | Won 5 |
| » W: Dennis Eckersley (10-5) L: Floyd Bannister (5-8) | Second | 1½ out |
| Friday, July 20 |
| » Lost to Mariners (41-55), 8-0 | Fenway Park (33-11) | 57-33 | |
| » W: Mike Parrott (7-7) L: Mike Torrez (9-6) | Second | 2½ out |
| Saturday, July 21 |
| » Lost to Mariners (42-55), 13-5 | Fenway Park (33-12) | 57-34 | Lost 2 |
| » W: John Montague (5-3) L: Steve Renko (8-4) S: Byron McLaughlin (7) | Second | 3½ out |
| Sunday, July 22 |
| » Defeated Angels (56-42), 6-5 | Fenway Park (34-12) | 58-34 | |
| » W: Bill Campbell (3-3) L: Mark Clear (10-3) | Second | 3½ out |
| Former Red Sox Amos Strunk dies in Llanerch, PA at the age of 91. |
| Monday, July 23 |
| » Lost to Angels (57-42), 9-2 | Fenway Park (34-13) | 58-35 | |
| » W: Dave Frost (8-6) L: Joel Finch (0-2) | Second | 4½ out |
| Tuesday, July 24 |
| » Defeated Athletics (26-74), 7-3 | Fenway Park (35-13) | 59-35 | |
| » W: Dennis Eckersley (11-5) L: Mike Morgan (0-6) | Second | 5 out |
| Wednesday, July 25 |
| » Defeated Athletics (26-75), 16-4 | Fenway Park (36-13) | 60-35 | Won 2 |
| » W: Mike Torrez (10-6) L: Brian Kingman (1-3) | Second | 4 out |
| Thursday, July 26 |
| » Lost to Athletics (27-75), 8-6 | Fenway Park (36-14) | 60-36 | |
| » W: Steve McCatty (6-5) L: Steve Renko (8-5) S: Dave Heaverlo (8) | Second | 5 out |
| Friday, July 27 |
| » Lost to Rangers (54-46), 11-2 | Arlington Stadium (1-3) | 60-37 | Lost 2 |
| » W: Steve Comer (11-6) L: Bob Stanley (11-7) | Second | 6 out |
| Saturday, July 28 |
| » Defeated Rangers (54-47), 1-0 | Arlington Stadium (2-3) | 61-37 | |
| » W: Dennis Eckersley (12-5) L: Fergie Jenkins (10-8) | Second | 5 out |
| Sunday, July 29 |
| » Defeated Rangers (54-48), 3-2 | Arlington Stadium (3-3) | 62-37 | Won 2 |
| » W: Mike Torrez (11-6) L: Doyle Alexander (3-6) S: Dick Drago (6) | Second | 5 out |
| Monday, July 30 |
| » Lost to Indians (51-52), 6-5 | Cleveland Stadium (1-2) | 62-38 | |
| » W: Victor Cruz (3-7) L: Tom Burgmeier (2-1) | Second | 6 out |
| Tuesday, July 31 |
| » Lost to Indians (52-52), 11-10 | Cleveland Stadium (1-3) | 62-39 | Lost 2 |
| » W: Sid Monge (7-6) L: Bill Campbell (3-4) | Second | 7½ out |
| » Lost to Indians (53-52), 3-0 | Cleveland Stadium (1-4) | 62-40 | Lost 3 |
| » W: Len Barker (1-4) L: Joel Finch (0-3) S: Sid Monge (13) | Second | 7½ out |
| Wednesday, August 1 |
| » Defeated Indians (53-53), 7-4 | Cleveland Stadium (2-4) | 63-40 | |
| » W: Dennis Eckersley (13-5) L: David Clyde (3-3) | Second | 7½ out |
| Thursday, August 2 |
| » Defeated Brewers (63-45), 10-1 | County Stadium (2-1) | 64-40 | Won 2 |
| » W: Mike Torrez (12-6) L: Bill Travers (9-5) | Second | 7 out |
| Friday, August 3 |
| » Lost to Brewers (64-45), 5-3 | County Stadium (2-2) | 64-41 | |
| » W: Jim Slaton (11-6) L: Steve Renko (8-6) S: Bill Castro (3) | Second | 8 out |
| Saturday, August 4 |
| » Defeated Brewers (64-46), 8-6 | County Stadium (3-2) | 65-41 | |
| » W: Allen Ripley (2-0) L: Reggie Cleveland (1-5) S: Dick Drago (7) | Second | 8 out |
| Sunday, August 5 |
| » Defeated Brewers (64-47), 7-2 | County Stadium (4-2) | 66-41 | Won 2 |
| » W: Dennis Eckersley (14-5) L: Lary Sorensen (12-12) | Second | 6½ out |
| » Defeated Brewers (64-48), 19-5 | County Stadium (5-2) | 67-41 | Won 3 |
| » W: Win Remmerswaal (1-0) L: Jerry Augustine (3-4) | Second | 6½ out |
| Tuesday, August 7 |
| » Defeated Indians (55-56), 12-3 | Fenway Park (37-14) | 68-41 | Won 4 |
| » W: Mike Torrez (13-6) L: David Clyde (3-4) | Second | 5 out |
| Former Red Sox Hal Wagner dies in Riverside, NJ at the age of 65. |
| Wednesday, August 8 |
| » Lost to Indians (56-56), 6-4 | Fenway Park (37-15) | 68-42 | |
| » W: Rick Wise (12-6) L: Bob Stanley (11-8) S: Sid Monge (14) | Second | 5½ out |
| » Lost to Indians (57-56), 8-2 | Fenway Park (37-16) | 68-43 | Lost 2 |
| » W: Dan Spillner (6-2) L: Steve Renko (8-7) | Second | 5½ out |
| Thursday, August 9 |
| » Defeated Indians (57-57), 3-2 | Fenway Park (38-16) | 69-43 | |
| » W: Dennis Eckersley (15-5) L: Rick Waits (11-10) | Second | 5½ out |
| Friday, August 10 |
| » Defeated Brewers (66-50), 5-4 | Fenway Park (39-16) | 70-43 | Won 2 |
| » W: Dick Drago (8-3) L: Bob McClure (5-2) | Second | 5½ out |
| Saturday, August 11 |
| » Lost to Brewers (67-50), 9-6 | Fenway Park (39-17) | 70-44 | |
| » W: Bob Galasso (2-0) L: Mike Torrez (13-7) | Second | 6 out |
| Monday, August 13 |
| » Defeated Twins (62-54), 6-5 | Fenway Park (40-17) | 71-44 | |
| » W: Tom Burgmeier (3-1) L: Mike Marshall (10-11) S: Dick Drago (8) | Second | 5 out |
| Tuesday, August 14 |
| » Defeated Twins (62-55), 12-1 | Fenway Park (41-17) | 72-44 | Won 2 |
| » W: Dennis Eckersley (16-5) L: Pete Redfern (6-2) | Second | 5 out |
| Future Red Sox Angel Santos is born in Rio Piedras, P.R. |
| Wednesday, August 15 |
| » Defeated Twins (62-56), 9-5 | Fenway Park (42-17) | 73-44 | Won 3 |
| » W: Dick Drago (9-3) L: Mike Bacsik (3-2) | Second | 5 out |
| Thursday, August 16 |
| » Defeated White Sox (53-66), 7-5 | Fenway Park (43-17) | 74-44 | Won 4 |
| » W: Allen Ripley (3-0) L: Mike Proly (1-5) | Second | 4 out |
| » Major-league debuts: John Tudor (Red Sox) |
| Friday, August 17 |
| » Lost to White Sox (54-66), 4-1 | Fenway Park (43-18) | 74-45 | |
| » W: Ross Baumgarten (11-7) L: Bob Stanley (11-9) S: Ed Farmer (9) | Second | 4 out |
| Saturday, August 18 |
| » Defeated White Sox (54-67), 8-2 | Fenway Park (44-18) | 75-45 | |
| » W: Steve Renko (9-7) L: Steve Trout (7-6) | Second | 4 out |
| Sunday, August 19 |
| » Lost to White Sox (55-67), 3-2 | Fenway Park (44-19) | 75-46 | |
| » W: Rich Wortham (13-11) L: Dennis Eckersley (16-6) S: Ed Farmer (10) | Second | 4 out |
| Monday, August 20 |
| » Lost to Twins (65-58), 10-5 | Metropolitan Stadium (2-2) | 75-47 | Lost 2 |
| » W: Roger Erickson (1-7) L: Mike Torrez (13-8) | Second | 5 out |
| Tuesday, August 21 |
| » Lost to Twins (66-58), 7-2 | Metropolitan Stadium (2-3) | 75-48 | Lost 3 |
| » W: Jerry Koosman (16-10) L: John Tudor (0-1) | Second | 5 out |
| Wednesday, August 22 |
| » Defeated Twins (66-59), 9-4 | Metropolitan Stadium (3-3) | 76-48 | |
| » W: Bob Stanley (12-9) L: Dave Goltz (11-9) | Second | 4½ out |
| Friday, August 24 |
| » Lost to Royals (66-61), 4-2 | Royals Stadium (2-2) | 76-49 | |
| » W: Craig Chamberlain (3-0) L: Dennis Eckersley (16-7) | Second | 5½ out |
| Saturday, August 25 |
| » Lost to Royals (67-61), 1-0 | Royals Stadium (2-3) | 76-50 | Lost 2 |
| » W: Dennis Leonard (9-9) L: Mike Torrez (13-9) | Second | 6 out |
| Sunday, August 26 |
| » Lost to Royals (68-61), 6-3 | Royals Stadium (2-4) | 76-51 | Lost 3 |
| » W: Paul Splittorff (13-13) L: Steve Renko (9-8) | Third | 7½ out |
| Monday, August 27 |
| » Defeated White Sox (56-73), 4-3 | Comiskey Park I (2-2) | 77-51 | |
| » W: Bob Stanley (13-9) L: Ken Kravec (11-12) S: Dick Drago (9) | Second | 7 out |
| Tuesday, August 28 |
| » Lost to White Sox (57-73), 7-3 | Comiskey Park I (2-3) | 77-52 | |
| » W: Ross Baumgarten (12-7) L: Allen Ripley (3-1) S: Ed Farmer (11) | Third | 7½ out |
| Thursday, August 30 |
| » Lost to Rangers (64-70), 6-0 | Fenway Park (44-20) | 77-53 | Lost 2 |
| » W: Doc Medich (6-6) L: Dennis Eckersley (16-8) | Third | 9½ out |
| Friday, August 31 |
| » Defeated Rangers (64-71), 9-6 | Fenway Park (45-20) | 78-53 | |
| » W: Mike Torrez (14-9) L: Steve Comer (13-10) S: Tom Burgmeier (3) | Third | 8½ out |
| Saturday, September 1 |
| » Lost to Rangers (65-71), 5-4 | Fenway Park (45-21) | 78-54 | |
| » W: Danny Darwin (4-4) L: Dick Drago (9-4) S: Jim Kern (22) | Third | 8½ out |
| Sunday, September 2 |
| » Lost to Rangers (66-71), 7-6 | Fenway Park (45-22) | 78-55 | Lost 2 |
| » W: Jim Kern (12-4) L: Dick Drago (9-5) | Third | 9½ out |
| Monday, September 3 |
| » Lost to Yankees (74-60), 10-6 | Yankee Stadium (2-3) | 78-56 | Lost 3 |
| » W: Ron Guidry (15-7) L: Dennis Eckersley (16-9) S: Ron Davis (8) | Third | 11 out |
| Tuesday, September 4 |
| » Lost to Yankees (75-60), 3-2 | Yankee Stadium (2-4) | 78-57 | Lost 4 |
| » W: Luis Tiant (11-8) L: Mike Torrez (14-10) S: Rich Gossage (13) | Third | 11½ out |
| Wednesday, September 5 |
| » Defeated Yankees (75-61), 5-0 | Yankee Stadium (3-4) | 79-57 | |
| » W: Bob Stanley (14-9) L: Tommy John (18-7) | Third | 11 out |
| Friday, September 7 |
| » Lost to Orioles (92-46), 2-1 | Fenway Park (45-23) | 79-58 | |
| » W: Sammy Stewart (8-5) L: Chuck Rainey (5-5) S: Don Stanhouse (17) | Third | 12½ out |
| Saturday, September 8 |
| » Lost to Orioles (93-46), 3-2 | Fenway Park (45-24) | 79-59 | Lost 2 |
| » W: Mike Flanagan (21-7) L: Dennis Eckersley (16-10) S: Don Stanhouse (18) | Third | 13½ out |
| Sunday, September 9 |
| » Lost to Orioles (94-46), 16-4 | Fenway Park (45-25) | 79-60 | Lost 3 |
| » W: Steve Stone (10-7) L: Mike Torrez (14-11) | Third | 14½ out |
| Monday, September 10 |
| » Defeated Orioles (94-47), 3-2 | Fenway Park (46-25) | 80-60 | |
| » W: Bob Stanley (15-9) L: Dennis Martinez (15-13) S: Dick Drago (10) | Third | 13½ out |
| Tuesday, September 11 |
| » Lost to Yankees (78-63), 8-3 | Fenway Park (46-26) | 80-61 | |
| » W: Ron Davis (11-2) L: Tom Burgmeier (3-2) S: Rich Gossage (15) | Third | 13½ out |
| Wednesday, September 12 |
| » Defeated Yankees (78-64), 9-2 | Fenway Park (47-26) | 81-61 | |
| » W: Chuck Rainey (6-5) L: Catfish Hunter (2-9) | Third | 12½ out |
| Thursday, September 13 |
| » Lost to Yankees (79-64), 10-3 | Fenway Park (47-27) | 81-62 | |
| » W: Ron Guidry (17-7) L: Mike Torrez (14-12) | Third | 13½ out |
| Friday, September 14 |
| » Lost to Orioles (96-49), 5-3 | Memorial Stadium (1-3) | 81-63 | Lost 2 |
| » W: Steve Stone (11-7) L: Bob Stanley (15-10) S: Don Stanhouse (19) | Third | 14½ out |
| Saturday, September 15 |
| » Defeated Orioles (96-50), 10-2 | Memorial Stadium (2-3) | 82-63 | |
| » W: Steve Renko (10-8) L: Dennis Martinez (15-14) S: Dick Drago (11) | Third | 13½ out |
| Sunday, September 16 |
| » Lost to Orioles (97-50), 13-3 | Memorial Stadium (2-4) | 82-64 | |
| » W: Jim Palmer (9-6) L: John Tudor (0-2) | Third | 14½ out |
| Monday, September 17 |
| » Lost to Blue Jays (50-99), 5-4 | Exhibition Stadium (1-2) | 82-65 | Lost 2 |
| » W: Jesse Jefferson (2-10) L: Dick Drago (9-6) | Third | 15 out |
| » Defeated Blue Jays (50-100), 5-3 | Exhibition Stadium (2-2) | 83-65 | |
| » W: Chuck Rainey (7-5) L: Dave Freisleben (2-3) S: Bill Campbell (9) | Third | 15 out |
| Tuesday, September 18 |
| » Defeated Blue Jays (50-101), 8-3 | Exhibition Stadium (3-2) | 84-65 | Won 2 |
| » W: Mike Torrez (15-12) L: Phil Huffman (6-16) | Third | 14 out |
| Wednesday, September 19 |
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