| Wednesday, April 4 |
| » Lost to Giants (1-0), 11-5 | Riverfront Stadium (0-1) | 0-1 | |
| » W: Vida Blue (1-0) L: Tom Seaver (0-1) | Third | 1 out |
| » Major-league debuts: Frank Pastore (Reds) |
| Friday, April 6 |
| » Lost to Giants (2-0), 7-2 | Riverfront Stadium (0-2) | 0-2 | Lost 2 |
| » W: John Montefusco (1-0) L: Tom Hume (0-1) S: Gary Lavelle (1) | Fifth | 2 out |
| Saturday, April 7 |
| » Lost to Giants (3-0), 4-2 | Riverfront Stadium (0-3) | 0-3 | Lost 3 |
| » W: Tom Griffin (1-0) L: Frank Pastore (0-1) S: Dave Roberts (1) | Sixth | 3 out |
| Sunday, April 8 |
| » Defeated Giants (3-1), 7-6 | Riverfront Stadium (1-3) | 1-3 | |
| » W: Doug Bair (1-0) L: John Curtis (0-1) | Third | 2½ out |
| » Major-league debuts: Max Venable (Giants) |
| Future Red Dane Sardinha is born in Honolulu, HI. |
| Monday, April 9 |
| » Defeated Braves (0-4), 9-4 | Atlanta-Fulton County Stadium (1-0) | 2-3 | Won 2 |
| » W: Tom Seaver (1-1) L: Mickey Mahler (0-1) | Third | 2 out |
| Tuesday, April 10 |
| » Lost to Braves (1-4), 6-4 | Atlanta-Fulton County Stadium (1-1) | 2-4 | |
| » W: Phil Niekro (1-1) L: Fred Norman (0-1) S: Gene Garber (1) | Third | 2½ out |
| Wednesday, April 11 |
| » Defeated Braves (1-5), 9-5 | Atlanta-Fulton County Stadium (2-1) | 3-4 | |
| » W: Tom Hume (1-1) L: Eddie Solomon (0-1) S: Frank Pastore (1) | Fourth | 2½ out |
| Friday, April 13 |
| » Defeated Padres (2-6), 4-2 | San Diego/Jack Murphy Stadium (1-0) | 4-4 | Won 2 |
| » W: Bill Bonham (1-0) L: Bob Shirley (0-2) S: Frank Pastore (2) | Third | 2 out |
| Saturday, April 14 |
| » Lost to Padres (3-6), 3-2 | San Diego/Jack Murphy Stadium (1-1) | 4-5 | |
| » W: Gaylord Perry (2-0) L: Tom Seaver (1-2) | Fourth | 3 out |
| Sunday, April 15 |
| » Lost to Padres (4-6), 6-3 | San Diego/Jack Murphy Stadium (1-2) | 4-6 | Lost 2 |
| » W: Randy Jones (2-1) L: Fred Norman (0-2) S: John D'Acquisto (1) | Third | 2½ out |
| » Defeated Padres (4-7), 7-5 | San Diego/Jack Murphy Stadium (2-2) | 5-6 | |
| » W: Doug Capilla (1-0) L: Mark Lee (0-1) S: Doug Bair (1) | Third | 2½ out |
| Tuesday, April 17 |
| » Defeated Braves (4-7), 7-4 | Riverfront Stadium (2-3) | 6-6 | Won 2 |
| » W: Tom Hume (2-1) L: Larry McWilliams (1-2) S: Doug Bair (2) | Third | 2 out |
| Thursday, April 19 |
| » Defeated Braves (4-8), 2-0 | Riverfront Stadium (3-3) | 7-6 | Won 3 |
| » W: Tom Seaver (2-2) L: Phil Niekro (1-3) | Third | 2 out |
| Friday, April 20 |
| » Defeated Cardinals (5-6), 10-3 | Busch Stadium II (1-0) | 8-6 | Won 4 |
| » W: Fred Norman (1-2) L: Bob Sykes (1-1) | Third | 2 out |
| Saturday, April 21 |
| » Defeated Cardinals (5-7), 4-1 | Busch Stadium II (2-0) | 9-6 | Won 5 |
| » W: Mike LaCoss (1-0) L: Silvio Martinez (0-1) S: Doug Bair (3) | Second | 2 out |
| Sunday, April 22 |
| » Lost to Cardinals (6-7), 4-3 | Busch Stadium II (2-1) | 9-7 | |
| » W: Buddy Schultz (1-1) L: Tom Hume (2-2) | Second | 3 out |
| Tuesday, April 24 |
| » Lost to Pirates (5-10), 9-2 | Riverfront Stadium (3-4) | 9-8 | Lost 2 |
| » W: Don Robinson (2-1) L: Frank Pastore (0-2) | Second | 3½ out |
| Wednesday, April 25 |
| » Lost to Pirates (6-10), 3-2 | Riverfront Stadium (3-5) | 9-9 | Lost 3 |
| » W: Kent Tekulve (1-3) L: Dave Tomlin (0-1) | Second | 3½ out |
| Friday, April 27 |
| » Defeated Cardinals (8-8), 4-3 | Riverfront Stadium (4-5) | 10-9 | |
| » W: Frank Pastore (1-2) L: Mark Littell (3-1) | Second | 4 out |
| Saturday, April 28 |
| » Lost to Cardinals (9-8), 12-1 | Riverfront Stadium (4-6) | 10-10 | |
| » W: Pete Vuckovich (2-0) L: Tom Hume (2-3) | Second | 4½ out |
| Sunday, April 29 |
| » Defeated Cardinals (9-9), 5-1 | Riverfront Stadium (5-6) | 11-10 | |
| » W: Paul Moskau (1-0) L: Bob Sykes (1-2) | Second | 3½ out |
| Tuesday, May 1 |
| » Lost to Cubs (9-9), 5-1 | Riverfront Stadium (5-7) | 11-11 | |
| » W: Ken Holtzman (2-1) L: Fred Norman (1-3) | Second | 4 out |
| Wednesday, May 2 |
| » Defeated Cubs (9-10), 4-1 | Riverfront Stadium (6-7) | 12-11 | |
| » W: Mike LaCoss (2-0) L: Rick Reuschel (1-4) S: Doug Bair (4) | Second | 3 out |
| Friday, May 4 |
| » Defeated Astros (16-9), 6-5 | Riverfront Stadium (7-7) | 13-11 | Won 2 |
| » W: Doug Bair (2-0) L: Frank Riccelli (1-1) | Second | 2½ out |
| Saturday, May 5 |
| » Defeated Astros (16-10), 6-2 | Riverfront Stadium (8-7) | 14-11 | Won 3 |
| » W: Tom Hume (3-3) L: Joaquin Andujar (3-1) S: Frank Pastore (3) | Second | 1½ out |
| Sunday, May 6 |
| » Defeated Astros (16-11), 17-5 | Riverfront Stadium (9-7) | 15-11 | Won 4 |
| » W: Pedro Borbon (1-0) L: J.R. Richard (4-1) | Second | 1½ out |
| » Lost to Astros (17-11), 8-2 | Riverfront Stadium (9-8) | 15-12 | |
| » W: Frank Riccelli (2-1) L: Fred Norman (1-4) | Second | 1½ out |
| Tuesday, May 8 |
| » Defeated Cubs (12-11), 8-7 | Wrigley Field (1-0) | 16-12 | |
| » W: Mike LaCoss (3-0) L: Ken Holtzman (2-2) S: Frank Pastore (4) | Second | ½ out |
| Wednesday, May 9 |
| » Defeated Cubs (12-12), 7-4 | Wrigley Field (2-0) | 17-12 | Won 2 |
| » W: Paul Moskau (2-0) L: Lynn McGlothen (3-3) S: Doug Bair (5) | Second | ½ out |
| Thursday, May 10 |
| » Lost to Cubs (13-12), 9-8 | Wrigley Field (2-1) | 17-13 | |
| » W: Lynn McGlothen (4-3) L: Manny Sarmiento (0-1) | Second | ½ out |
| Friday, May 11 |
| » Defeated Pirates (11-16), 8-4 | Three Rivers Stadium (1-0) | 18-13 | |
| » W: Dave Tomlin (1-1) L: Ed Whitson (1-2) S: Doug Bair (6) | First | -- |
| Saturday, May 12 |
| » Lost to Pirates (12-16), 3-2 | Three Rivers Stadium (1-1) | 18-14 | |
| » W: Jim Bibby (3-1) L: Frank Pastore (1-3) S: Grant Jackson (4) | First | -- |
| Future Red Travis Dawkins is born in Newberry, SC. |
| Sunday, May 13 |
| » Defeated Pirates (12-17), 7-3 | Three Rivers Stadium (2-1) | 19-14 | |
| » W: Mike LaCoss (4-0) L: John Candelaria (2-2) | First | -- |
| Monday, May 14 |
| » Defeated Padres (14-22), 7-4 | Riverfront Stadium (10-8) | 20-14 | Won 2 |
| » W: Paul Moskau (3-0) L: Eric Rasmussen (0-4) S: Dave Tomlin (1) | First | -- |
| Tuesday, May 15 |
| » Lost to Padres (15-22), 2-1 | Riverfront Stadium (10-9) | 20-15 | |
| » W: Rollie Fingers (2-2) L: Frank Pastore (1-4) | First | -- |
| Wednesday, May 16 |
| » Defeated Padres (15-23), 7-0 | Riverfront Stadium (11-9) | 21-15 | |
| » W: Bill Bonham (2-0) L: Steve Mura (2-2) | First | -- |
| Friday, May 18 |
| » Defeated Dodgers (19-21), 7-6 | Riverfront Stadium (12-9) | 22-15 | Won 2 |
| » W: Pedro Borbon (2-0) L: Jerry Reuss (1-3) | First | -- |
| Saturday, May 19 |
| » Defeated Dodgers (19-22), 5-4 | Riverfront Stadium (13-9) | 23-15 | Won 3 |
| » W: Paul Moskau (4-0) L: Rick Sutcliffe (4-3) S: Pedro Borbon (1) | First | -- |
| Sunday, May 20 |
| » Lost to Dodgers (20-22), 6-4 | Riverfront Stadium (13-10) | 23-16 | |
| » W: Don Sutton (5-3) L: Tom Hume (3-4) S: Bob Welch (3) | First | -- |
| Tuesday, May 22 |
| » Lost to Giants (23-19), 12-2 | Candlestick Park (0-1) | 23-17 | Lost 2 |
| » W: Ed Halicki (5-3) L: Bill Bonham (2-1) | First | -- |
| Wednesday, May 23 |
| » Defeated Giants (23-20), 5-0 | Candlestick Park (1-1) | 24-17 | |
| » W: Mike LaCoss (5-0) L: Vida Blue (6-5) | First | -- |
| Thursday, May 24 |
| » Lost to Giants (24-20), 2-1 | Candlestick Park (1-2) | 24-18 | |
| » W: Philip Nastu (2-2) L: Paul Moskau (4-1) S: Randy Moffitt (1) | First | -- |
| Friday, May 25 |
| » Lost to Dodgers (22-24), 17-6 | Dodger Stadium (0-1) | 24-19 | Lost 2 |
| » W: Rick Sutcliffe (5-3) L: Tom Seaver (2-3) | First | -- |
| Saturday, May 26 |
| » Defeated Dodgers (22-25), 3-1 | Dodger Stadium (1-1) | 25-19 | |
| » W: Fred Norman (2-4) L: Don Sutton (5-4) | First | -- |
| Sunday, May 27 |
| » Lost to Dodgers (23-25), 8-7 | Dodger Stadium (1-2) | 25-20 | |
| » W: Lerrin LaGrow (1-3) L: Pedro Borbon (2-1) S: Bob Welch (4) | First | -- |
| Monday, May 28 |
| » Defeated Dodgers (23-26), 3-2 | Dodger Stadium (2-2) | 26-20 | |
| » W: Dave Tomlin (2-1) L: Charlie Hough (0-2) S: Tom Hume (1) | First | -- |
| Tuesday, May 29 |
| » Lost to Astros (27-23), 2-1 | Astrodome (0-1) | 26-21 | |
| » W: Randy Niemann (1-0) L: Paul Moskau (4-2) | First | -- |
| Wednesday, May 30 |
| » Lost to Astros (28-23), 6-3 | Astrodome (0-2) | 26-22 | Lost 2 |
| » W: Joe Niekro (7-2) L: Tom Seaver (2-4) S: Joe Sambito (4) | Second | 1½ out |
| Thursday, May 31 |
| » Lost to Astros (29-23), 3-0 | Astrodome (0-3) | 26-23 | Lost 3 |
| » W: Rick Williams (2-1) L: Fred Norman (2-5) | Second | 1½ out |
| Friday, June 1 |
| » Defeated Phillies (27-21), 4-2 | Riverfront Stadium (14-10) | 27-23 | |
| » W: Doug Bair (3-0) L: Steve Carlton (6-6) S: Pedro Borbon (2) | Second | 1½ out |
| Saturday, June 2 |
| » Defeated Phillies (27-22), 4-2 | Riverfront Stadium (15-10) | 28-23 | Won 2 |
| » W: Mike LaCoss (6-0) L: Randy Lerch (2-4) S: Doug Bair (7) | Second | 1½ out |
| Sunday, June 3 |
| » Lost to Phillies (28-22), 6-4 | Riverfront Stadium (15-11) | 28-24 | |
| » W: Ron Reed (5-1) L: Pedro Borbon (2-2) S: Tug McGraw (4) | Second | 2 out |
| » Defeated Phillies (28-23), 12-2 | Riverfront Stadium (16-11) | 29-24 | |
| » W: Tom Hume (4-4) L: Jim Lonborg (0-1) | Second | 2 out |
| Monday, June 4 |
| » Lost to Mets (19-29), 6-2 | Riverfront Stadium (16-12) | 29-25 | |
| » W: Craig Swan (5-4) L: Tom Seaver (2-5) | Second | 3 out |
| Tuesday, June 5 |
| » Defeated Mets (19-30), 6-1 | Riverfront Stadium (17-12) | 30-25 | |
| » W: Fred Norman (3-5) L: Kevin Kobel (2-1) | Second | 2 out |
| Wednesday, June 6 |
| » Lost to Mets (20-30), 5-3 | Riverfront Stadium (17-13) | 30-26 | |
| » W: Dale Murray (3-5) L: Manny Sarmiento (0-2) S: Ed Glynn (2) | Second | 3 out |
| Friday, June 8 |
| » Defeated Expos (31-20), 3-2 | Riverfront Stadium (18-13) | 31-26 | |
| » W: Mike LaCoss (7-0) L: Dan Schatzeder (1-1) | Second | 3 out |
| Saturday, June 9 |
| » Defeated Expos (31-21), 7-1 | Riverfront Stadium (19-13) | 32-26 | Won 2 |
| » W: Tom Seaver (3-5) L: Bill Lee (6-3) | Second | 2 out |
| Sunday, June 10 |
| » Defeated Expos (31-22), 3-2 | Riverfront Stadium (20-13) | 33-26 | Won 3 |
| » W: Tom Hume (5-4) L: Elias Sosa (3-3) S: Doug Bair (8) | Second | 2 out |
| Monday, June 11 |
| » Lost to Mets (22-32), 3-2 | Shea Stadium (0-1) | 33-27 | |
| » W: Wayne Twitchell (1-0) L: Fred Norman (3-6) | Second | 2 out |
| Tuesday, June 12 |
| » Lost to Mets (23-32), 12-6 | Shea Stadium (0-2) | 33-28 | Lost 2 |
| » W: Dale Murray (4-5) L: Manny Sarmiento (0-3) | Second | 2 out |
| Wednesday, June 13 |
| » Defeated Mets (23-33), 4-1 | Shea Stadium (1-2) | 34-28 | |
| » W: Mike LaCoss (8-0) L: Tom Hausman (0-1) S: Tom Hume (2) | Second | 2 out |
| Friday, June 15 |
| » Defeated Phillies (32-29), 6-3 | Veteran's Stadium (1-0) | 35-28 | Won 2 |
| » W: Tom Seaver (4-5) L: Larry Christenson (1-4) | Second | 2 out |
| Saturday, June 16 |
| » Lost to Phillies (33-29), 4-3 | Veteran's Stadium (1-1) | 35-29 | |
| » W: Tug McGraw (3-0) L: Doug Bair (3-1) | Second | 2 out |
| Sunday, June 17 |
| » Lost to Phillies (34-29), 9-3 | Veteran's Stadium (1-2) | 35-30 | Lost 2 |
| » W: Randy Lerch (4-4) L: Doug Bair (3-2) | Second | 2 out |
| Monday, June 18 |
| » Defeated Expos (36-24), 3-2 | Stade Olympique (1-0) | 36-30 | |
| » W: Bill Bonham (3-1) L: Steve Rogers (6-4) S: Doug Bair (9) | Second | 2 out |
| Tuesday, June 19 |
| » Lost to Expos (37-24), 3-2 | Stade Olympique (1-1) | 36-31 | |
| » W: Bill Lee (7-3) L: Mike LaCoss (8-1) S: Woodie Fryman (3) | Second | 3 out |
| Wednesday, June 20 |
| » Lost to Expos (38-24), 5-4 | Stade Olympique (1-2) | 36-32 | Lost 2 |
| » W: Elias Sosa (5-4) L: Tom Hume (5-5) | Second | 4 out |
| Friday, June 22 |
| » Lost to Giants (34-35), 3-2 | Riverfront Stadium (20-14) | 36-33 | Lost 3 |
| » W: Philip Nastu (3-4) L: Paul Moskau (4-3) S: Tom Griffin (2) | Second | 5 out |
| Saturday, June 23 |
| » Lost to Giants (35-35), 5-2 | Riverfront Stadium (20-15) | 36-34 | Lost 4 |
| » W: John Curtis (3-3) L: Fred Norman (3-7) S: Gary Lavelle (9) | Second | 6 out |
| Sunday, June 24 |
| » Defeated Giants (35-36), 8-7 | Riverfront Stadium (21-15) | 37-34 | |
| » W: Doug Bair (4-2) L: Dave Roberts (0-2) | Second | 6 out |
| Monday, June 25 |
| » Defeated Astros (44-30), 2-1 | Astrodome (1-3) | 38-34 | Won 2 |
| » W: Tom Seaver (5-5) L: J.R. Richard (6-7) S: Doug Bair (10) | Second | 6 out |
| » Lost to Astros (45-30), 4-0 | Astrodome (1-4) | 38-35 | |
| » W: Randy Niemann (3-0) L: Mike LaCoss (8-2) | Second | 6 out |
| Tuesday, June 26 |
| » Lost to Astros (46-30), 6-5 | Astrodome (1-5) | 38-36 | Lost 2 |
| » W: Bert Roberge (2-0) L: Doug Bair (4-3) S: Joe Sambito (7) | Second | 7 out |
| Wednesday, June 27 |
| » Defeated Dodgers (33-43), 9-1 | Dodger Stadium (3-2) | 39-36 | |
| » W: Fred Norman (4-7) L: Jerry Reuss (2-7) | Second | 6 out |
| Thursday, June 28 |
| » Defeated Dodgers (33-44), 2-1 | Dodger Stadium (4-2) | 40-36 | Won 2 |
| » W: Tom Hume (6-5) L: Burt Hooton (7-5) S: Doug Bair (11) | Second | 6 out |
| Friday, June 29 |
| » Lost to Giants (38-38), 6-4 | Candlestick Park (1-3) | 40-37 | |
| » W: Pedro Borbon (3-2) L: Manny Sarmiento (0-4) S: Gary Lavelle (10) | Second | 7 out |
| Saturday, June 30 |
| » Defeated Giants (38-39), 2-0 | Candlestick Park (2-3) | 41-37 | |
| » W: Tom Seaver (6-5) L: Ed Whitson (2-4) | Second | 7 out |
| Sunday, July 1 |
| » Lost to Giants (39-39), 2-1 | Candlestick Park (2-4) | 41-38 | |
| » W: John Curtis (4-4) L: Mike LaCoss (8-3) S: Pedro Borbon (3) | Second | 8½ out |
| » Lost to Giants (40-39), 7-3 | Candlestick Park (2-5) | 41-39 | Lost 2 |
| » W: Gary Lavelle (7-4) L: Mario Soto (0-1) | Second | 8½ out |
| Tuesday, July 3 |
| » Lost to Astros (51-31), 3-2 | Riverfront Stadium (21-16) | 41-40 | Lost 3 |
| » W: Ken Forsch (5-3) L: Doug Bair (4-4) | Second | 9½ out |
| Wednesday, July 4 |
| » Lost to Astros (52-31), 3-2 | Riverfront Stadium (21-17) | 41-41 | Lost 4 |
| » W: Joaquin Andujar (10-4) L: Bill Bonham (3-2) S: Joe Sambito (9) | Second | 10½ out |
| Thursday, July 5 |
| » Defeated Astros (52-32), 5-4 | Riverfront Stadium (22-17) | 42-41 | |
| » W: Tom Seaver (7-5) L: J.R. Richard (7-8) S: Doug Bair (12) | Second | 9½ out |
| Friday, July 6 |
| » Defeated Pirates (40-36), 2-1 | Riverfront Stadium (23-17) | 43-41 | Won 2 |
| » W: Doug Bair (5-4) L: Grant Jackson (4-2) | Second | 9½ out |
| Saturday, July 7 |
| » Defeated Pirates (40-37), 6-2 | Riverfront Stadium (24-17) | 44-41 | Won 3 |
| » W: Paul Moskau (5-3) L: Don Robinson (5-5) | Second | 8 out |
| Sunday, July 8 |
| » Defeated Pirates (40-38), 4-2 | Riverfront Stadium (25-17) | 45-41 | Won 4 |
| » W: Fred Norman (5-7) L: John Candelaria (7-7) | Second | 7½ out |
| » Lost to Pirates (41-38), 2-1 | Riverfront Stadium (25-18) | 45-42 | |
| » W: Grant Jackson (5-2) L: Dave Tomlin (2-2) S: Kent Tekulve (11) | Second | 7½ out |
| Monday, July 9 |
| » Lost to Cardinals (42-39), 6-3 | Riverfront Stadium (25-19) | 45-43 | Lost 2 |
| » W: Pete Vuckovich (8-5) L: Bill Bonham (3-3) S: Mark Littell (5) | Second | 8 out |
| Tuesday, July 10 |
| » Defeated Cardinals (42-40), 4-2 | Riverfront Stadium (26-19) | 46-43 | |
| » W: Tom Seaver (8-5) L: John Fulgham (2-2) S: Doug Bair (13) | Second | 7 out |
| Wednesday, July 11 |
| » Defeated Cardinals (42-41), 6-1 | Riverfront Stadium (27-19) | 47-43 | Won 2 |
| » W: Mike LaCoss (9-3) L: John Denny (4-7) | Second | 6 out |
| Thursday, July 12 |
| » Lost to Cubs (46-37), 10-8 | Riverfront Stadium (27-20) | 47-44 | |
| » W: Bruce Sutter (4-2) L: Doug Bair (5-5) | Second | 6 out |
| Friday, July 13 |
| » Lost to Cubs (47-37), 3-1 | Riverfront Stadium (27-21) | 47-45 | Lost 2 |
| » W: Dennis Lamp (7-4) L: Fred Norman (5-8) S: Bruce Sutter (21) | Second | 6 out |
| Saturday, July 14 |
| » Lost to Cubs (48-37), 1-0 | Riverfront Stadium (27-22) | 47-46 | Lost 3 |
| » W: Mike Krukow (7-5) L: Bill Bonham (3-4) S: Bruce Sutter (22) | Second | 7 out |
| Sunday, July 15 |
| » Defeated Cubs (48-38), 7-1 | Riverfront Stadium (28-22) | 48-46 | |
| » W: Tom Seaver (9-5) L: Rick Reuschel (8-6) | Second | 6 out |
| Thursday, July 19 |
| » Defeated Cardinals (44-43), 16-4 | Busch Stadium II (3-1) | 49-46 | Won 2 |
| » W: Fred Norman (6-8) L: Pete Vuckovich (8-7) | Second | 4½ out |
| Friday, July 20 |
| » Defeated Cardinals (44-44), 3-0 | Busch Stadium II (4-1) | 50-46 | Won 3 |
| » W: Tom Seaver (10-5) L: John Denny (4-8) | Second | 3½ out |
| Saturday, July 21 |
| » Lost to Cardinals (45-44), 12-3 | Busch Stadium II (4-2) | 50-47 | |
| » W: Silvio Martinez (8-3) L: Mike LaCoss (9-4) | Second | 3½ out |
| Sunday, July 22 |
| » Defeated Cubs (50-40), 12-1 | Wrigley Field (3-1) | 51-47 | |
| » W: Bill Bonham (4-4) L: Ken Holtzman (6-7) | Second | 4 out |
| » Lost to Cubs (51-40), 8-4 | Wrigley Field (3-2) | 51-48 | |
| » W: Dick Tidrow (9-3) L: Mario Soto (0-2) | Second | 4 out |
| Monday, July 23 |
| » Lost to Cubs (52-40), 2-1 | Wrigley Field (3-3) | 51-49 | Lost 2 |
| » W: Willie Hernandez (2-0) L: Tom Hume (6-6) | Second | 5 out |
| Tuesday, July 24 |
| » Defeated Pirates (53-41), 6-5 | Three Rivers Stadium (3-1) | 52-49 | |
| » W: Fred Norman (7-8) L: Bruce Kison (6-5) S: Doug Bair (14) | Second | 5 out |
| Wednesday, July 25 |
| » Defeated Pirates (53-42), 6-5 | Three Rivers Stadium (4-1) | 53-49 | Won 2 |
| » W: Doug Bair (6-5) L: Kent Tekulve (3-6) | Second | 5 out |
| Thursday, July 26 |
| » Defeated Pirates (53-43), 9-7 | Three Rivers Stadium (5-1) | 54-49 | Won 3 |
| » W: Mario Soto (1-2) L: Dave Roberts (1-3) S: Tom Hume (3) | Second | 4 out |
| Friday, July 27 |
| » Defeated Braves (42-61), 2-0 | Atlanta-Fulton County Stadium (3-1) | 55-49 | Won 4 |
| » W: Mike LaCoss (10-4) L: Phil Niekro (14-12) S: Doug Bair (15) | Second | 3 out |
| Saturday, July 28 |
| » Defeated Braves (42-62), 8-6 | Atlanta-Fulton County Stadium (4-1) | 56-49 | Won 5 |
| » W: Bill Bonham (5-4) L: Tony Brizzolara (5-6) S: Tom Hume (4) | Second | 3½ out |
| » Lost to Braves (43-62), 8-5 | Atlanta-Fulton County Stadium (4-2) | 56-50 | |
| » W: Mickey Mahler (3-9) L: Frank Pastore (1-5) | Second | 3½ out |
| Sunday, July 29 |
| » Defeated Braves (43-63), 9-4 | Atlanta-Fulton County Stadium (5-2) | 57-50 | |
| » W: Fred Norman (8-8) L: Rick Matula (6-7) S: Tom Hume (5) | Second | 3½ out |
| Monday, July 30 |
| » Defeated Dodgers (44-61), 9-4 | Riverfront Stadium (29-22) | 58-50 | Won 2 |
| » W: Doug Bair (7-5) L: Ken Brett (2-2) | Second | 2½ out |
| Tuesday, July 31 |
| » Lost to Dodgers (45-61), 7-6 | Riverfront Stadium (29-23) | 58-51 | |
| » W: Don Sutton (8-12) L: Paul Moskau (5-4) S: Dave Patterson (3) | Second | 3½ out |
| Wednesday, August 1 |
| » Defeated Dodgers (45-62), 10-5 | Riverfront Stadium (30-23) | 59-51 | |
| » W: Mike LaCoss (11-4) L: Charlie Hough (2-3) S: Tom Hume (6) | Second | 3½ out |
| Friday, August 3 |
| » Lost to Padres (50-61), 6-4 | Riverfront Stadium (30-24) | 59-52 | |
| » W: Bob Shirley (5-11) L: Bill Bonham (5-5) S: Mark Lee (2) | Second | 4½ out |
| Saturday, August 4 |
| » Defeated Padres (50-62), 7-1 | Riverfront Stadium (31-24) | 60-52 | |
| » W: Fred Norman (9-8) L: John D'Acquisto (7-9) | Second | 5 out |
| Sunday, August 5 |
| » Defeated Padres (50-63), 9-1 | Riverfront Stadium (32-24) | 61-52 | Won 2 |
| » W: Frank Pastore (2-5) L: Randy Jones (8-7) | Second | 5 out |
| Monday, August 6 |
| » Defeated Braves (45-69), 3-1 | Riverfront Stadium (33-24) | 62-52 | Won 3 |
| » W: Mike LaCoss (12-4) L: Mickey Mahler (3-10) | Second | 4½ out |
| Tuesday, August 7 |
| » Lost to Braves (46-69), 3-2 | Riverfront Stadium (33-25) | 62-53 | |
| » W: Gene Garber (6-13) L: Doug Bair (7-6) | Second | 4½ out |
| Wednesday, August 8 |
| » Defeated Braves (46-70), 3-1 | Riverfront Stadium (34-25) | 63-53 | |
| » W: Bill Bonham (6-5) L: Phil Niekro (14-15) | Second | 4½ out |
| Thursday, August 9 |
| » Defeated Braves (46-71), 5-2 | Riverfront Stadium (35-25) | 64-53 | Won 2 |
| » W: Fred Norman (10-8) L: Gene Garber (6-14) S: Tom Hume (7) | Second | 3½ out |
| Friday, August 10 |
| » Lost to Padres (52-65), 3-2 | San Diego/Jack Murphy Stadium (2-3) | 64-54 | |
| » W: Randy Jones (9-7) L: Frank Pastore (2-6) | Second | 4½ out |
| Sunday, August 12 |
| » Defeated Padres (52-66), 9-2 | San Diego/Jack Murphy Stadium (3-3) | 65-54 | |
| » W: Tom Seaver (11-5) L: Gaylord Perry (10-9) | Second | 4 out |
| » Lost to Padres (53-66), 5-4 | San Diego/Jack Murphy Stadium (3-4) | 65-55 | |
| » W: Mark Lee (2-2) L: Mike LaCoss (12-5) S: Eric Rasmussen (2) | Second | 4 out |
| Tuesday, August 14 |
| » Defeated Phillies (60-59), 2-1 | Riverfront Stadium (36-25) | 66-55 | |
| » W: Tom Hume (7-6) L: Steve Carlton (11-10) | Second | 4½ out |
| Wednesday, August 15 |
| » Lost to Phillies (61-59), 3-2 | Riverfront Stadium (36-26) | 66-56 | |
| » W: Nino Espinosa (13-9) L: Fred Norman (10-9) | Second | 4½ out |
| Friday, August 17 |
| » Defeated Mets (51-67), 4-3 | Riverfront Stadium (37-26) | 67-56 | |
| » W: Tom Hume (8-6) L: Dale Murray (4-7) | Second | 3½ out |
| Saturday, August 18 |
| » Defeated Mets (51-68), 4-3 | Riverfront Stadium (38-26) | 68-56 | Won 2 |
| » W: Mike LaCoss (13-5) L: Neil Allen (4-6) | Second | 2½ out |
| Sunday, August 19 |
| » Defeated Mets (51-69), 6-5 | Riverfront Stadium (39-26) | 69-56 | Won 3 |
| » W: Doug Bair (8-6) L: Dale Murray (4-8) S: Tom Hume (8) | Second | 1½ out |
| Monday, August 20 |
| » Lost to Expos (68-51), 5-2 | Riverfront Stadium (39-27) | 69-57 | |
| » W: Dan Schatzeder (9-4) L: Fred Norman (10-10) S: Woodie Fryman (7) | Second | 2½ out |
| Tuesday, August 21 |
| » Defeated Expos (68-52), 3-2 | Riverfront Stadium (40-27) | 70-57 | |
| » W: Tom Seaver (12-5) L: Rudy May (7-1) S: Tom Hume (9) | Second | 1½ out |
| Wednesday, August 22 |
| » Defeated Expos (68-53), 7-2 | Riverfront Stadium (41-27) | 71-57 | Won 2 |
| » W: Mike LaCoss (14-5) L: Steve Rogers (11-8) | Second | 1½ out |
| Friday, August 24 |
| » Defeated Mets (52-72), 1-0 | Shea Stadium (2-2) | 72-57 | Won 3 |
| » W: Bill Bonham (7-5) L: Neil Allen (4-7) S: Tom Hume (10) | Second | ½ out |
| Saturday, August 25 |
| » Defeated Mets (52-73), 8-4 | Shea Stadium (3-2) | 73-57 | Won 4 |
| » W: Doug Bair (9-6) L: Jeff Reardon (1-1) | Second | ½ out |
| » Major-league debuts: Jeff Reardon (Mets) |
| Sunday, August 26 |
| » Defeated Mets (52-74), 8-0 | Shea Stadium (4-2) | 74-57 | Won 5 |
| » W: Tom Seaver (13-5) L: Pete Falcone (5-10) | Second | ½ out |
| Monday, August 27 |
| » Defeated Phillies (65-65), 4-2 | Veteran's Stadium (2-2) | 75-57 | Won 6 |
| » W: Tom Hume (9-6) L: Larry Christenson (4-10) | Second | ½ out |
| Tuesday, August 28 |
| » Defeated Phillies (65-66), 5-2 | Veteran's Stadium (3-2) | 76-57 | Won 7 |
| » W: Frank Pastore (3-6) L: Steve Carlton (13-11) S: Tom Hume (11) | First | -- |
| Wednesday, August 29 |
| » Defeated Phillies (65-67), 7-6 | Veteran's Stadium (4-2) | 77-57 | Won 8 |
| » W: Mario Soto (2-2) L: Kevin Saucier (1-3) S: Doug Bair (16) | First | -- |
| Friday, August 31 |
| » Lost to Expos (72-54), 8-7 | Stade Olympique (1-3) | 77-58 | |
| » W: Woodie Fryman (3-5) L: Tom Hume (9-7) | First | -- |
| Saturday, September 1 |
| » Lost to Expos (73-54), 7-2 | Stade Olympique (1-4) | 77-59 | Lost 2 |
| » W: David Palmer (7-2) L: Tom Seaver (13-6) | Second | ½ out |
| Sunday, September 2 |
| » Lost to Expos (74-54), 13-1 | Stade Olympique (1-5) | 77-60 | Lost 3 |
| » W: Steve Rogers (12-8) L: Mike LaCoss (14-6) | Second | ½ out |
| Monday, September 3 |
| » Defeated Braves (53-83), 6-5 | Atlanta-Fulton County Stadium (6-2) | 78-60 | |
| » W: Doug Bair (10-6) L: Gene Garber (6-15) S: Tom Hume (12) | First | -- |
| Tuesday, September 4 |
| » Lost to Braves (54-83), 7-6 | Atlanta-Fulton County Stadium (6-3) | 78-61 | |
| » W: Joey McLaughlin (5-3) L: Doug Bair (10-7) S: Larry Bradford (1) | Second | ½ out |
| Wednesday, September 5 |
| » Defeated Giants (61-79), 6-5 | Riverfront Stadium (42-27) | 79-61 | |
| » W: Fred Norman (11-10) L: John Montefusco (3-7) S: Tom Hume (13) | Second | ½ out |
| Thursday, September 6 |
| » Defeated Giants (61-80), 12-3 | Riverfront Stadium (43-27) | 80-61 | Won 2 |
| » W: Tom Seaver (14-6) L: Bob Knepper (9-11) | Second | ½ out |
| Friday, September 7 |
| » Lost to Dodgers (67-74), 6-5 | Riverfront Stadium (43-28) | 80-62 | |
| » W: Bobby Castillo (2-0) L: Tom Hume (9-8) S: Gerry Hannahs (1) | Second | ½ out |
| Saturday, September 8 |
| » Defeated Dodgers (67-75), 4-1 | Riverfront Stadium (44-28) | 81-62 | |
| » W: Bill Bonham (8-5) L: Jerry Reuss (5-13) S: Tom Hume (14) | First | -- |
| Sunday, September 9 |
| » Lost to Dodgers (68-75), 3-1 | Riverfront Stadium (44-29) | 81-63 | |
| » W: Rick Sutcliffe (14-9) L: Fred Norman (11-11) S: Lerrin LaGrow (4) | Second | ½ out |
| Tuesday, September 11 |
| » Defeated Astros (81-63), 9-8 | Riverfront Stadium (45-29) | 82-63 | |
| » W: Tom Hume (10-8) L: Joe Sambito (7-6) | First | -- |
| Wednesday, September 12 |
| » Defeated Astros (81-64), 7-4 | Riverfront Stadium (46-29) | 83-63 | Won 2 |
| » W: Frank Pastore (4-6) L: Joe Niekro (18-10) S: Tom Hume (15) | First | -- |
| Friday, September 14 |
| » Lost to Dodgers (71-76), 2-0 | Dodger Stadium (4-3) | 83-64 | |
| » W: Rick Sutcliffe (15-9) L: Bill Bonham (8-6) | First | -- |
| Saturday, September 15 |
| » Defeated Dodgers (71-77), 2-1 | Dodger Stadium (5-3) | 84-64 | |
| » W: Mario Soto (3-2) L: Joe Beckwith (1-2) | First | -- |
| Sunday, September 16 |
| » Defeated Dodgers (71-78), 2-0 | Dodger Stadium (6-3) | 85-64 | Won 2 |
| » W: Tom Seaver (15-6) L: Don Sutton (12-15) | First | -- |
| Monday, September 17 |
| » Lost to Giants (67-84), 7-4 | Candlestick Park (2-6) | 85-65 | |
| » W: Vida Blue (13-13) L: Mike LaCoss (14-7) S: Gary Lavelle (19) | First | -- |
| » Major-league debuts: Charlie Leibrandt (Reds) |
| Tuesday, September 18 |
| » Lost to Giants (68-84), 3-1 | Candlestick Park (2-7) | 85-66 | Lost 2 |
| » W: Ed Whitson (7-10) L: Frank Pastore (4-7) S: Greg Minton (3) | First | -- |
| Wednesday, September 19 |
| » Defeated Padres (63-89), 3-2 | San Diego/Jack Murphy Stadium (4-4) | 86-66 | |
| » W: Bill Bonham (9-6) L: Bob Shirley (7-16) S: Tom Hume (16) | First | -- |
| Thursday, September 20 |
| » Defeated Padres (63-90), 8-5 | San Diego/Jack Murphy Stadium (5-4) | 87-66 | Won 2 |
| » W: Doug Bair (11-7) L: Steve Mura (3-3) | First | -- |
| Friday, September 21 |
| » Lost to Astros (85-68) |