| Saturday, March 3 |
| Future Oriole Jorge Julio is born in Caracas, Venezuela. |
| Monday, March 5 |
| Future Oriole Erik Bedard is born in Navan, ON. |
| Wednesday, April 4 |
| » Major-league debuts: Mark Clear (Angels) |
| Friday, April 6 |
| » Defeated White Sox (0-1), 5-3 | Memorial Stadium (1-0) | 1-0 | |
| » W: Jim Palmer (1-0) L: Ken Kravec (0-1) | First | -- |
| Saturday, April 7 |
| » Defeated White Sox (0-2), 6-3 | Memorial Stadium (2-0) | 2-0 | Won 2 |
| » W: Mike Flanagan (1-0) L: Mike Proly (0-1) S: Sammy Stewart (1) | First | -- |
| Sunday, April 8 |
| » Lost to White Sox (1-2), 5-1 | Memorial Stadium (2-1) | 2-1 | |
| » W: Rich Wortham (1-0) L: Dennis Martinez (0-1) S: Lerrin LaGrow (1) | First | -- |
| Tuesday, April 10 |
| » Lost to Yankees (2-2), 7-6 | Memorial Stadium (2-2) | 2-2 | Lost 2 |
| » W: Rich Gossage (1-0) L: Sammy Stewart (0-1) S: Dick Tidrow (1) | Third | 1 out |
| Wednesday, April 11 |
| » Defeated Yankees (2-3), 6-5 | Memorial Stadium (3-2) | 3-2 | |
| » W: Don Stanhouse (1-0) L: Rich Gossage (1-1) | Second | ½ out |
| Thursday, April 12 |
| » Lost to Yankees (3-3), 5-0 | Memorial Stadium (3-3) | 3-3 | |
| » W: Tommy John (2-0) L: Mike Flanagan (1-1) | Second | ½ out |
| Friday, April 13 |
| » Lost to Brewers (4-2), 9-3 | County Stadium (0-1) | 3-4 | Lost 2 |
| » W: Lary Sorensen (1-1) L: Steve Stone (0-1) | Fourth | 1½ out |
| Saturday, April 14 |
| » Lost to Brewers (5-2), 11-10 | County Stadium (0-2) | 3-5 | Lost 3 |
| » W: Bob McClure (2-0) L: Tim Stoddard (0-1) | Fifth | 2½ out |
| Sunday, April 15 |
| » Lost to Brewers (6-2), 4-2 | County Stadium (0-3) | 3-6 | Lost 4 |
| » W: Mike Caldwell (3-0) L: Jim Palmer (1-1) | Sixth | 3½ out |
| Tuesday, April 17 |
| » Lost to Yankees (6-4), 5-1 | Yankee Stadium (0-1) | 3-7 | Lost 5 |
| » W: Ron Guidry (1-1) L: Mike Flanagan (1-2) | Sixth | 3½ out |
| Wednesday, April 18 |
| » Lost to Yankees (7-4), 3-1 | Yankee Stadium (0-2) | 3-8 | Lost 6 |
| » W: Tommy John (3-0) L: Dennis Martinez (0-2) S: Rich Gossage (3) | Seventh | 4½ out |
| Thursday, April 19 |
| » Defeated Yankees (7-5), 6-3 | Yankee Stadium (1-2) | 4-8 | |
| » W: Jim Palmer (2-1) L: Paul Mirabella (0-1) | Sixth | 3½ out |
| Friday, April 20 |
| » Defeated Brewers (7-5), 6-3 | Memorial Stadium (4-3) | 5-8 | Won 2 |
| » W: Steve Stone (1-1) L: Mike Caldwell (3-1) S: Don Stanhouse (1) | Fifth | 3 out |
| Saturday, April 21 |
| » Defeated Brewers (7-6), 4-2 | Memorial Stadium (5-3) | 6-8 | Won 3 |
| » W: Sammy Stewart (1-1) L: Bill Travers (0-1) S: Don Stanhouse (2) | Fifth | 3 out |
| Sunday, April 22 |
| » Defeated Brewers (7-7), 6-2 | Memorial Stadium (6-3) | 7-8 | Won 4 |
| » W: Dennis Martinez (1-2) L: Moose Haas (0-1) | Fourth | 2½ out |
| » Defeated Brewers (7-8), 7-3 | Memorial Stadium (7-3) | 8-8 | Won 5 |
| » W: Mike Flanagan (2-2) L: Lary Sorensen (2-2) | Fourth | 2½ out |
| Tuesday, April 24 |
| » Defeated Angels (12-5), 7-2 | Anaheim Stadium (1-0) | 9-8 | Won 6 |
| » W: Jim Palmer (3-1) L: Don Aase (2-1) | Fourth | 2½ out |
| Wednesday, April 25 |
| » Defeated Angels (12-6), 5-2 | Anaheim Stadium (2-0) | 10-8 | Won 7 |
| » W: Steve Stone (2-1) L: Frank Tanana (2-3) S: Don Stanhouse (3) | Third | 2½ out |
| Thursday, April 26 |
| » Defeated Angels (12-7), 4-2 | Anaheim Stadium (3-0) | 11-8 | Won 8 |
| » W: Tim Stoddard (1-1) L: Dave LaRoche (1-2) | Third | 2½ out |
| Friday, April 27 |
| » Defeated Athletics (6-13), 7-1 | Oakland-Alameda County Stadium (1-0) | 12-8 | Won 9 |
| » W: Mike Flanagan (3-2) L: Matt Keough (0-3) | Second | 1½ out |
| Saturday, April 28 |
| » Lost to Athletics (7-13), 8-5 | Oakland-Alameda County Stadium (1-1) | 12-9 | |
| » W: Jim Todd (2-1) L: Scott McGregor (0-1) S: Dave Heaverlo (2) | Third | 1½ out |
| Future Oriole Sean Douglass is born in Lancaster, CA. |
| Sunday, April 29 |
| » Defeated Athletics (7-14), 13-1 | Oakland-Alameda County Stadium (2-1) | 13-9 | |
| » W: Tippy Martinez (1-0) L: John Henry Johnson (0-4) | Second | 1½ out |
| Monday, April 30 |
| » Defeated Mariners (8-15), 8-7 | Kingdome (1-0) | 14-9 | Won 2 |
| » W: Don Stanhouse (2-0) L: Rick Honeycutt (0-4) | Second | 1½ out |
| Tuesday, May 1 |
| » Defeated Mariners (8-16), 3-1 | Kingdome (2-0) | 15-9 | Won 3 |
| » W: Dennis Martinez (2-2) L: Byron McLaughlin (1-1) | First | -- |
| Wednesday, May 2 |
| » Defeated Mariners (8-17), 9-3 | Kingdome (3-0) | 16-9 | Won 4 |
| » W: Mike Flanagan (4-2) L: Paul Mitchell (0-3) | First | -- |
| Saturday, May 5 |
| » Defeated Angels (16-10), 9-1 | Memorial Stadium (8-3) | 17-9 | Won 5 |
| » W: Jim Palmer (4-1) L: Don Aase (2-3) | Second | 1 out |
| Sunday, May 6 |
| » Defeated Angels (16-11), 6-0 | Memorial Stadium (9-3) | 18-9 | Won 6 |
| » W: Dennis Martinez (3-2) L: Mike Barlow (0-1) | First | -- |
| Monday, May 7 |
| » Lost to Athletics (11-17), 5-3 | Memorial Stadium (9-4) | 18-10 | |
| » W: Rick Langford (1-4) L: Tippy Martinez (1-1) | Second | 1 out |
| Tuesday, May 8 |
| » Defeated Athletics (11-18), 8-2 | Memorial Stadium (10-4) | 19-10 | |
| » W: Mike Flanagan (5-2) L: Jim Todd (2-2) | First | -- |
| Wednesday, May 9 |
| » Lost to Athletics (12-18), 4-2 | Memorial Stadium (10-5) | 19-11 | |
| » W: Mike Norris (3-1) L: Jim Palmer (4-2) | Second | 1 out |
| Thursday, May 10 |
| » Defeated Athletics (12-19), 3-1 | Memorial Stadium (11-5) | 20-11 | |
| » W: Dennis Martinez (4-2) L: John Henry Johnson (0-5) | First | -- |
| Friday, May 11 |
| » Defeated Mariners (10-23), 8-3 | Memorial Stadium (12-5) | 21-11 | Won 2 |
| » W: Steve Stone (3-1) L: Byron McLaughlin (1-2) | First | -- |
| Saturday, May 12 |
| » Defeated Mariners (10-24), 4-2 | Memorial Stadium (13-5) | 22-11 | Won 3 |
| » W: Mike Flanagan (6-2) L: Rick Honeycutt (1-5) | First | -- |
| Tuesday, May 15 |
| » Lost to Red Sox (22-11), 3-2 | Fenway Park (0-1) | 22-12 | |
| » W: Dennis Eckersley (4-2) L: Don Stanhouse (2-1) | Second | ½ out |
| Wednesday, May 16 |
| » Defeated Red Sox (22-12), 10-6 | Fenway Park (1-1) | 23-12 | |
| » W: Dennis Martinez (5-2) L: Andy Hassler (1-2) S: Tim Stoddard (1) | First | -- |
| Thursday, May 17 |
| » Lost to Red Sox (23-12), 6-2 | Fenway Park (1-2) | 23-13 | |
| » W: Bob Stanley (4-2) L: Steve Stone (3-2) S: Dick Drago (4) | Second | ½ out |
| Friday, May 18 |
| » Defeated Blue Jays (10-29), 7-6 | Exhibition Stadium (1-0) | 24-13 | |
| » W: Don Stanhouse (3-1) L: Dave Freisleben (1-1) | First | -- |
| Saturday, May 19 |
| » Defeated Blue Jays (10-30), 4-3 | Exhibition Stadium (2-0) | 25-13 | Won 2 |
| » W: Jim Palmer (5-2) L: Tom Underwood (0-6) S: Don Stanhouse (4) | First | -- |
| Sunday, May 20 |
| » Defeated Blue Jays (10-31), 6-2 | Exhibition Stadium (3-0) | 26-13 | Won 3 |
| » W: Dennis Martinez (6-2) L: Jesse Jefferson (0-3) | First | -- |
| Tuesday, May 22 |
| » Lost to Red Sox (25-14), 7-5 | Memorial Stadium (13-6) | 26-14 | |
| » W: Steve Renko (3-1) L: Mike Flanagan (6-3) S: Bill Campbell (3) | First | -- |
| Wednesday, May 23 |
| » Defeated Red Sox (25-15), 5-2 | Memorial Stadium (14-6) | 27-14 | |
| » W: Tippy Martinez (2-1) L: Bob Stanley (4-3) | First | -- |
| Thursday, May 24 |
| » Defeated Red Sox (25-16), 5-3 | Memorial Stadium (15-6) | 28-14 | Won 2 |
| » W: Dennis Martinez (7-2) L: Mike Torrez (4-3) | First | -- |
| Saturday, May 26 |
| » Defeated Tigers (16-21), 7-5 | Tiger Stadium (1-0) | 29-14 | Won 3 |
| » W: Sammy Stewart (2-1) L: John Hiller (3-3) | First | -- |
| Sunday, May 27 |
| » Lost to Tigers (17-21), 5-1 | Tiger Stadium (1-1) | 29-15 | |
| » W: Jack Billingham (5-3) L: Scott McGregor (0-2) | First | -- |
| » Lost to Tigers (18-21), 10-3 | Tiger Stadium (1-2) | 29-16 | Lost 2 |
| » W: Dave Rozema (2-2) L: Steve Stone (3-3) | First | -- |
| Monday, May 28 |
| » Lost to Royals (27-20), 5-4 | Royals Stadium (0-1) | 29-17 | Lost 3 |
| » W: Larry Gura (2-5) L: Sammy Stewart (2-2) | First | -- |
| Tuesday, May 29 |
| » Defeated Royals (27-21), 8-1 | Royals Stadium (1-1) | 30-17 | |
| » W: Jim Palmer (6-2) L: Paul Splittorff (7-4) | First | -- |
| Wednesday, May 30 |
| » Lost to Royals (28-21), 2-1 | Royals Stadium (1-2) | 30-18 | |
| » W: Rich Gale (5-3) L: Mike Flanagan (6-4) S: Al Hrabosky (7) | First | -- |
| Friday, June 1 |
| » Lost to Rangers (29-20), 4-2 | Arlington Stadium (0-1) | 30-19 | Lost 2 |
| » W: Steve Comer (5-4) L: Steve Stone (3-4) S: Jim Kern (8) | First | -- |
| Saturday, June 2 |
| » Defeated Rangers (29-21), 5-4 | Arlington Stadium (1-1) | 31-19 | |
| » W: Tippy Martinez (3-1) L: Sparky Lyle (3-5) S: Don Stanhouse (5) | First | -- |
| Sunday, June 3 |
| » Lost to Rangers (30-21), 4-2 | Arlington Stadium (1-2) | 31-20 | |
| » W: Doyle Alexander (3-3) L: Jim Palmer (6-3) S: Jim Kern (9) | First | -- |
| Monday, June 4 |
| » Defeated Twins (28-22), 3-2 | Memorial Stadium (16-6) | 32-20 | |
| » W: Don Stanhouse (4-1) L: Mike Marshall (8-5) | First | -- |
| Tuesday, June 5 |
| » Lost to Twins (29-22), 3-1 | Memorial Stadium (16-7) | 32-21 | |
| » W: Paul Hartzell (3-3) L: Steve Stone (3-5) S: Mike Marshall (12) | Second | 1 out |
| Wednesday, June 6 |
| » Defeated Royals (31-24), 3-0 | Memorial Stadium (17-7) | 33-21 | |
| » W: Dennis Martinez (8-2) L: Paul Splittorff (8-5) | First | -- |
| Thursday, June 7 |
| » Defeated Royals (31-25), 3-1 | Memorial Stadium (18-7) | 34-21 | Won 2 |
| » W: Sammy Stewart (3-2) L: Renie Martin (0-3) | First | -- |
| Friday, June 8 |
| » Defeated Rangers (31-25), 3-0 | Memorial Stadium (19-7) | 35-21 | Won 3 |
| » W: Mike Flanagan (7-4) L: Doyle Alexander (3-4) | First | -- |
| Saturday, June 9 |
| » Defeated Rangers (31-26), 4-3 | Memorial Stadium (20-7) | 36-21 | Won 4 |
| » W: Steve Stone (4-5) L: Dock Ellis (1-5) S: Don Stanhouse (6) | First | -- |
| Sunday, June 10 |
| » Defeated Rangers (31-27), 5-4 | Memorial Stadium (21-7) | 37-21 | Won 5 |
| » W: Dennis Martinez (9-2) L: Jim Kern (7-1) | First | -- |
| Monday, June 11 |
| » Defeated White Sox (28-30), 6-0 | Comiskey Park I (1-0) | 38-21 | Won 6 |
| » W: Scott McGregor (1-2) L: Rich Wortham (6-5) | First | -- |
| Tuesday, June 12 |
| » Lost to White Sox (29-30), 12-4 | Comiskey Park I (1-1) | 38-22 | |
| » W: Ken Kravec (7-4) L: Mike Flanagan (7-5) | First | -- |
| Wednesday, June 13 |
| » Defeated White Sox (29-31), 8-7 | Comiskey Park I (2-1) | 39-22 | |
| » W: Tim Stoddard (2-1) L: Steve Trout (1-2) | First | -- |
| Friday, June 15 |
| » Defeated Twins (32-28), 6-5 | Metropolitan Stadium (1-0) | 40-22 | Won 2 |
| » W: Don Stanhouse (5-1) L: Mike Marshall (8-6) S: Tim Stoddard (2) | First | -- |
| » Major-league debuts: Wayne Krenchicki (Orioles) |
| Sunday, June 17 |
| » Defeated Twins (32-29), 8-5 | Metropolitan Stadium (2-0) | 41-22 | Won 3 |
| » W: Mike Flanagan (8-5) L: Jerry Koosman (7-6) S: Tim Stoddard (3) | First | -- |
| Monday, June 18 |
| » Defeated Indians (32-32), 8-7 | Cleveland Stadium (1-0) | 42-22 | Won 4 |
| » W: Don Stanhouse (6-1) L: Victor Cruz (0-3) | First | -- |
| Tuesday, June 19 |
| » Defeated Indians (32-33), 6-4 | Cleveland Stadium (2-0) | 43-22 | Won 5 |
| » W: Tim Stoddard (3-1) L: Mike Paxton (4-3) | First | -- |
| Wednesday, June 20 |
| » Defeated Indians (32-34), 5-3 | Cleveland Stadium (3-0) | 44-22 | Won 6 |
| » W: Dennis Martinez (10-2) L: Rick Waits (9-5) | First | -- |
| Friday, June 22 |
| » Defeated Tigers (31-33), 6-5 | Memorial Stadium (22-7) | 45-22 | Won 7 |
| » W: Tippy Martinez (4-1) L: Dave Tobik (1-2) | First | -- |
| Saturday, June 23 |
| » Defeated Tigers (31-34), 8-6 | Memorial Stadium (23-7) | 46-22 | Won 8 |
| » W: Tippy Martinez (5-1) L: John Hiller (3-6) | First | -- |
| » Defeated Tigers (31-35), 6-5 | Memorial Stadium (24-7) | 47-22 | Won 9 |
| » W: Sammy Stewart (4-2) L: Jack Billingham (6-4) | First | -- |
| Sunday, June 24 |
| » Lost to Tigers (32-35), 6-4 | Memorial Stadium (24-8) | 47-23 | |
| » W: Aurelio Lopez (3-1) L: Dennis Martinez (10-3) | First | -- |
| Monday, June 25 |
| » Defeated Indians (32-38), 3-2 | Memorial Stadium (25-8) | 48-23 | |
| » W: Steve Stone (5-5) L: Wayne Garland (3-8) S: Don Stanhouse (7) | First | -- |
| Tuesday, June 26 |
| » Defeated Indians (32-39), 4-3 | Memorial Stadium (26-8) | 49-23 | Won 2 |
| » W: Mike Flanagan (9-5) L: Len Barker (0-1) S: Don Stanhouse (8) | First | -- |
| Wednesday, June 27 |
| » Defeated Indians (32-40), 3-1 | Memorial Stadium (27-8) | 50-23 | Won 3 |
| » W: Jim Palmer (7-3) L: Mike Paxton (4-4) | First | -- |
| Thursday, June 28 |
| » Lost to Indians (33-40), 6-3 | Memorial Stadium (27-9) | 50-24 | |
| » W: Rick Wise (7-5) L: Dennis Martinez (10-4) S: Sid Monge (6) | First | -- |
| Friday, June 29 |
| » Defeated Blue Jays (24-54), 6-1 | Memorial Stadium (28-9) | 51-24 | |
| » W: Scott McGregor (2-2) L: Dave Stieb (0-1) | First | -- |
| » Defeated Blue Jays (24-55), 4-0 | Memorial Stadium (29-9) | 52-24 | Won 2 |
| » W: Steve Stone (6-5) L: Phil Huffman (4-9) S: Don Stanhouse (9) | First | -- |
| » Major-league debuts: Dave Stieb (Blue Jays) |
| Saturday, June 30 |
| » Defeated Blue Jays (24-56), 2-0 | Memorial Stadium (30-9) | 53-24 | Won 3 |
| » W: Mike Flanagan (10-5) L: Tom Underwood (2-11) | First | -- |
| Sunday, July 1 |
| » Defeated Blue Jays (24-57), 10-7 | Memorial Stadium (31-9) | 54-24 | Won 4 |
| » W: Sammy Stewart (5-2) L: Jesse Jefferson (1-8) S: Don Stanhouse (10) | First | -- |
| Monday, July 2 |
| » Lost to Rangers (45-34), 2-0 | Arlington Stadium (1-3) | 54-25 | |
| » W: Steve Comer (8-6) L: Dennis Martinez (10-5) | First | -- |
| Tuesday, July 3 |
| » Lost to Rangers (46-34), 4-0 | Arlington Stadium (1-4) | 54-26 | Lost 2 |
| » W: Fergie Jenkins (9-4) L: Steve Stone (6-6) | First | -- |
| Wednesday, July 4 |
| » Lost to Rangers (47-34), 9-5 | Arlington Stadium (1-5) | 54-27 | Lost 3 |
| » W: Danny Darwin (2-0) L: Mike Flanagan (10-6) S: Jim Kern (14) | First | -- |
| Thursday, July 5 |
| » Major-league debuts: Dickie Noles (Phillies) |
| Friday, July 6 |
| » Lost to Angels (49-36), 7-3 | Anaheim Stadium (3-1) | 54-28 | Lost 4 |
| » W: Jim Barr (5-4) L: Steve Stone (6-7) | First | -- |
| Saturday, July 7 |
| » Lost to Angels (50-36), 10-1 | Anaheim Stadium (3-2) | 54-29 | Lost 5 |
| » W: Dave Frost (7-4) L: Dennis Martinez (10-6) | First | -- |
| Sunday, July 8 |
| » Defeated Angels (50-37), 3-2 | Anaheim Stadium (4-2) | 55-29 | |
| » W: Scott McGregor (3-2) L: Don Aase (7-7) S: Don Stanhouse (11) | First | -- |
| Monday, July 9 |
| » Defeated Athletics (24-65), 7-3 | Oakland-Alameda County Stadium (3-1) | 56-29 | Won 2 |
| » W: Mike Flanagan (11-6) L: Matt Keough (0-11) S: Don Stanhouse (12) | First | -- |
| Tuesday, July 10 |
| » Lost to Athletics (25-65), 7-6 | Oakland-Alameda County Stadium (3-2) | 56-30 | |
| » W: Rick Langford (5-9) L: Sammy Stewart (5-3) S: Dave Heaverlo (7) | First | -- |
| Wednesday, July 11 |
| » Defeated Athletics (25-66), 3-1 | Oakland-Alameda County Stadium (4-2) | 57-30 | |
| » W: Dennis Martinez (11-6) L: Steve McCatty (5-4) | First | -- |
| Friday, July 13 |
| » Lost to Mariners (40-52), 4-3 | Kingdome (3-1) | 57-31 | |
| » W: Odell Jones (3-8) L: Scott McGregor (3-3) | First | -- |
| Saturday, July 14 |
| » Defeated Mariners (40-53), 5-2 | Kingdome (4-1) | 58-31 | |
| » W: Mike Flanagan (12-6) L: Mike Parrott (6-7) | First | -- |
| Sunday, July 15 |
| » Defeated Mariners (40-54), 6-1 | Kingdome (5-1) | 59-31 | Won 2 |
| » W: Dennis Martinez (12-6) L: Rick Honeycutt (6-6) | First | -- |
| Thursday, July 19 |
| » Lost to Angels (56-38), 4-3 | Memorial Stadium (31-10) | 59-32 | |
| » W: Dave LaRoche (3-7) L: Dennis Martinez (12-7) | First | -- |
| » Defeated Angels (56-39), 3-0 | Memorial Stadium (32-10) | 60-32 | |
| » W: Mike Flanagan (13-6) L: Dave Frost (7-6) | First | -- |
| Friday, July 20 |
| » Defeated Angels (56-40), 2-1 | Memorial Stadium (33-10) | 61-32 | Won 2 |
| » W: Scott McGregor (4-3) L: Jim Barr (7-5) | First | -- |
| Saturday, July 21 |
| » Defeated Angels (56-41), 10-2 | Memorial Stadium (34-10) | 62-32 | Won 3 |
| » W: Sammy Stewart (6-3) L: Nolan Ryan (12-7) | First | -- |
| Sunday, July 22 |
| » Defeated Athletics (26-72), 4-1 | Memorial Stadium (35-10) | 63-32 | Won 4 |
| » W: Steve Stone (7-7) L: Rick Langford (5-11) | First | -- |
| Monday, July 23 |
| » Defeated Athletics (26-73), 7-4 | Memorial Stadium (36-10) | 64-32 | Won 5 |
| » W: Tippy Martinez (6-1) L: Matt Keough (0-12) | First | -- |
| Tuesday, July 24 |
| » Defeated Mariners (42-58), 7-6 | Memorial Stadium (37-10) | 65-32 | Won 6 |
| » W: Dennis Martinez (13-7) L: Floyd Bannister (5-9) S: Don Stanhouse (13) | First | -- |
| » Defeated Mariners (42-59), 11-3 | Memorial Stadium (38-10) | 66-32 | Won 7 |
| » W: Scott McGregor (5-3) L: Odell Jones (3-9) | First | -- |
| Wednesday, July 25 |
| » Lost to Mariners (43-59), 5-4 | Memorial Stadium (38-11) | 66-33 | |
| » W: Mike Parrott (8-7) L: Sammy Stewart (6-4) S: Byron McLaughlin (8) | First | -- |
| Thursday, July 26 |
| » Defeated Mariners (43-60), 12-1 | Memorial Stadium (39-11) | 67-33 | |
| » W: Steve Stone (8-7) L: Randy Stein (0-1) | First | -- |
| Friday, July 27 |
| » Defeated Royals (49-51), 8-0 | Royals Stadium (2-2) | 68-33 | Won 2 |
| » W: Mike Flanagan (14-6) L: Dennis Leonard (6-8) | First | -- |
| Saturday, July 28 |
| » Lost to Royals (50-51), 6-3 | Royals Stadium (2-3) | 68-34 | |
| » W: Rich Gale (8-8) L: Dennis Martinez (13-8) | First | -- |
| Sunday, July 29 |
| » Defeated Royals (50-52), 6-4 | Royals Stadium (3-3) | 69-34 | |
| » W: Scott McGregor (6-3) L: Paul Splittorff (10-11) S: Dave Ford (1) | First | -- |
| Monday, July 30 |
| » Defeated Brewers (63-42), 2-1 | County Stadium (1-3) | 70-34 | Won 2 |
| » W: Steve Stone (9-7) L: Jim Slaton (10-6) S: Tippy Martinez (1) | First | -- |
| Tuesday, July 31 |
| » Defeated Brewers (63-43), 9-5 | County Stadium (2-3) | 71-34 | Won 3 |
| » W: Sammy Stewart (7-4) L: Paul Mitchell (2-7) | First | -- |
| Wednesday, August 1 |
| » Defeated Brewers (63-44), 5-2 | County Stadium (3-3) | 72-34 | Won 4 |
| » W: Dennis Martinez (14-8) L: Lary Sorensen (12-11) | First | -- |
| Thursday, August 2 |
| Future Oriole Matt Riley is born in Antioch, CA. |
| Friday, August 3 |
| » Defeated Yankees (58-49), 1-0 | Yankee Stadium (2-2) | 73-34 | Won 5 |
| » W: Scott McGregor (7-3) L: Luis Tiant (7-6) S: Tippy Martinez (2) | First | -- |
| Saturday, August 4 |
| » Defeated Yankees (58-50), 5-4 | Yankee Stadium (3-2) | 74-34 | Won 6 |
| » W: Dave Ford (1-0) L: Jim Kaat (3-2) S: Tippy Martinez (3) | First | -- |
| Sunday, August 5 |
| » Lost to Yankees (59-50), 3-2 | Yankee Stadium (3-3) | 74-35 | |
| » W: Tommy John (15-6) L: Mike Flanagan (14-7) | First | -- |
| Monday, August 6 |
| » Lost to Yankees (60-50), 5-4 | Yankee Stadium (3-4) | 74-36 | Lost 2 |
| » W: Ron Guidry (10-7) L: Tippy Martinez (6-2) | First | -- |
| Tuesday, August 7 |
| » Lost to Brewers (65-48), 7-5 | Memorial Stadium (39-12) | 74-37 | Lost 3 |
| » W: Jerry Augustine (4-4) L: Sammy Stewart (7-5) | First | -- |
| Wednesday, August 8 |
| » Lost to Brewers (66-48), 8-4 | Memorial Stadium (39-13) | 74-38 | Lost 4 |
| » W: Bill Travers (10-5) L: Don Stanhouse (6-2) | First | -- |
| Thursday, August 9 |
| » Defeated Brewers (66-49), 3-2 | Memorial Stadium (40-13) | 75-38 | |
| » W: Mike Flanagan (15-7) L: Jerry Augustine (4-5) | First | -- |
| Friday, August 10 |
| » Defeated Yankees (61-53), 8-6 | Memorial Stadium (41-13) | 76-38 | Won 2 |
| » W: Tippy Martinez (7-2) L: Ron Davis (9-2) | First | -- |
| Monday, August 13 |
| » Lost to White Sox (53-63), 7-0 | Memorial Stadium (41-14) | 76-39 | |
| » W: Steve Trout (7-5) L: Scott McGregor (7-4) | First | -- |
| Tuesday, August 14 |
| » Defeated White Sox (53-64), 2-1 | Memorial Stadium (42-14) | 77-39 | |
| » W: Tippy Martinez (8-2) L: Ed Farmer (2-4) | First | -- |
| Wednesday, August 15 |
| » Defeated White Sox (53-65), 2-1 | Memorial Stadium (43-14) | 78-39 | Won 2 |
| » W: Mike Flanagan (16-7) L: Guy Hoffman (0-3) | First | -- |
| Thursday, August 16 |
| » Lost to Royals (62-58), 4-2 | Memorial Stadium (43-15) | 78-40 | |
| » W: Paul Splittorff (12-12) L: Dennis Martinez (14-9) | First | -- |
| Friday, August 17 |
| » Lost to Royals (63-58), 7-1 | Memorial Stadium (43-16) | 78-41 | Lost 2 |
| » W: Craig Chamberlain (2-0) L: Jim Palmer (7-4) | First | -- |
| Saturday, August 18 |
| » Defeated Royals (63-59), 9-2 | Memorial Stadium (44-16) | 79-41 | |
| » W: Scott McGregor (8-4) L: Larry Gura (8-9) S: Dave Ford (2) | First | -- |
| Sunday, August 19 |
| » Lost to Royals (64-59), 11-7 | Memorial Stadium (44-17) | 79-42 | |
| » W: Steve Busby (6-6) L: Don Stanhouse (6-3) | First | -- |
| Monday, August 20 |
| » Defeated Rangers (61-64), 3-0 | Memorial Stadium (45-17) | 80-42 | |
| » W: Mike Flanagan (17-7) L: Brian Allard (1-2) | First | -- |
| Tuesday, August 21 |
| » Lost to Rangers (62-64), 2-1 | Memorial Stadium (45-18) | 80-43 | |
| » W: Steve Comer (13-8) L: Dennis Martinez (14-10) S: Jim Kern (21) | First | -- |
| Thursday, August 23 |
| » Defeated Rangers (62-65), 6-5 | Memorial Stadium (46-18) | 81-43 | |
| » W: Scott McGregor (9-4) L: Fergie Jenkins (13-10) S: Don Stanhouse (14) | First | -- |
| Sunday, August 26 |
| » Defeated White Sox (56-71), 12-7 | Comiskey Park I (3-1) | 82-43 | Won 2 |
| » W: Mike Flanagan (18-7) L: Steve Trout (7-7) | First | -- |
| » Defeated White Sox (56-72), 4-3 | Comiskey Park I (4-1) | 83-43 | Won 3 |
| » W: Don Stanhouse (7-3) L: Ed Farmer (3-5) | First | -- |
| Monday, August 27 |
| » Lost to Twins (68-60), 4-3 | Metropolitan Stadium (2-1) | 83-44 | |
| » W: Pete Redfern (7-2) L: Dennis Martinez (14-11) S: Mike Marshall (27) | First | -- |
| » Defeated Twins (68-61), 5-1 | Metropolitan Stadium (3-1) | 84-44 | |
| » W: Jim Palmer (8-4) L: Dave Goltz (11-10) | First | -- |
| Wednesday, August 29 |
| » Defeated Twins (68-62), 4-0 | Metropolitan Stadium (4-1) | 85-44 | Won 2 |
| » W: Scott McGregor (10-4) L: Roger Erickson (1-8) | First | -- |
| » Defeated Twins (68-63), 7-4 | Metropolitan Stadium (5-1) | 86-44 | Won 3 |
| » W: Dave Ford (2-0) L: Geoff Zahn (10-5) S: Don Stanhouse (15) | First | -- |
| Thursday, August 30 |
| » Defeated Twins (68-64), 5-4 | Memorial Stadium (47-18) | 87-44 | Won 4 |
| » W: Mike Flanagan (19-7) L: Jerry Koosman (17-11) S: Don Stanhouse (16) | First | -- |
| Friday, August 31 |
| » Lost to Twins (69-64), 3-1 | Memorial Stadium (47-19) | 87-45 | |
| » W: Dave Goltz (12-10) L: Dennis Martinez (14-12) S: Mike Marshall (28) | First | -- |
| Future Oriole Tim Raines, Jr. is born in Memphis, TN. |
| Saturday, September 1 |
| » Lost to Twins (70-64), 3-2 | Memorial Stadium (47-20) | 87-46 | Lost 2 |
| » W: Paul Hartzell (6-7) L: Jim Palmer (8-5) S: Mike Marshall (29) | First | -- |
| » Major-league debuts: Mark Corey (Orioles) |
| Sunday, September 2 |
| » Defeated Twins (70-65), 3-1 | Memorial Stadium (48-20) | 88-46 | |
| » W: Scott McGregor (11-4) L: Roger Erickson (1-9) | First | -- |
| Monday, September 3 |
| » Defeated Blue Jays (44-93), 2-1 | Memorial Stadium (49-20) | 89-46 | Won 2 |
| » W: Tippy Martinez (9-2) L: Tom Buskey (6-7) | First | -- |
| » Defeated Blue Jays (44-94), 5-1 | Memorial Stadium (50-20) | 90-46 | Won 3 |
| » W: Mike Flanagan (20-7) L: Dave Lemanczyk (8-10) | First | -- |
| Thursday, September 6 |
| » Defeated Blue Jays (44-95), 5-0 | Memorial Stadium (51-20) | 91-46 | Won 4 |
| » W: Dennis Martinez (15-12) L: Butch Edge (2-2) | First | -- |
| Friday, September 7 |
| » Defeated Red Sox (79-58), 2-1 | Fenway Park (2-2) | 92-46 | Won 5 |
| » W: Sammy Stewart (8-5) L: Chuck Rainey (5-5) S: Don Stanhouse (17) | First | -- |
| Saturday, September 8 |
| » Defeated Red Sox (79-59), 3-2 | Fenway Park (3-2) | 93-46 | Won 6 |
| » W: Mike Flanagan (21-7) L: Dennis Eckersley (16-10) S: Don Stanhouse (18) | First | -- |
| Sunday, September 9 |
| » Defeated Red Sox (79-60), 16-4 | Fenway Park (4-2) | 94-46 | Won 7 |
| » W: Steve Stone (10-7) L: Mike Torrez (14-11) | First | -- |
| Monday, September 10 |
| » Lost to Red Sox (80-60), 3-2 | Fenway Park (4-3) | 94-47 | |
| » W: Bob Stanley (15-9) L: Dennis Martinez (15-13) S: Dick Drago (10) | First | -- |
| Tuesday, September 11 |
| » Lost to Blue Jays (45-98), 3-1 | Exhibition Stadium (3-1) | 94-48 | Lost 2 |
| » W: Tom Underwood (7-16) L: Scott McGregor (11-5) | First | -- |
| Wednesday, September 12 |
| » Lost to Blue Jays (46-98), 3-2 | Exhibition Stadium (3-2) | 94-49 | Lost 3 |
| » W: Butch Edge (3-2) L: Jim Palmer (8-6) | First | -- |
| Thursday, September 13 |
| » Defeated Blue Jays (46-99), 10-4 | Exhibition Stadium (4-2) | 95-49 | |
| » W: Mike Flanagan (22-7) L: Phil Huffman (6-15) | First | -- |
| Friday, September 14 |
| » Defeated Red Sox (81-63), 5-3 | Memorial Stadium (52-20) | 96-49 | Won 2 |
| » W: Steve Stone (11-7) L: Bob Stanley (15-10) S: Don Stanhouse (19) | First | -- |
| Saturday, September 15 |
| » Lost to Red Sox (82-63), 10-2 | Memorial Stadium (52-21) | 96-50 | |
| » W: Steve Renko (10-8) L: Dennis Martinez (15-14) S: Dick Drago (11) | First | -- |
| Sunday, September 16 |
| » Defeated Red Sox (82-64), 13-3 | Memorial Stadium (53-21) | 97-50 | |
| » W: Jim Palmer (9-6) L: John Tudor (0-2) | First | -- |
| Monday, September 17 |
| » Defeated Tigers (79-70), 2-1 | Tiger Stadium (2-2) | 98-50 | Won 2 |
| » W: Scott McGregor (12-5) L: Milt Wilcox (12-8) | First | -- |
| Tuesday, September 18 |
| » Lost to Tigers (80-70), 2-1 | Tiger Stadium (2-3) | 98-51 | |
| » W: Dan Petry (6-5) L: Mike Flanagan (22-8) S: Aurelio Lopez (20) | First | -- |
| Wednesday, September 19 |
| » Lost to Tigers (81-70), 5-0 | Tiger Stadium (2-4) | 98-52 | Lost 2 |
| » W: Jack Morris (15-7) L: Dennis Martinez (15-15) | First | -- |
| Thursday, September 20 |
| » Defeated Tigers (81-71), 8-7 | Tiger Stadium (3-4) | 99-52 | |
| » W: Tippy Martinez (10-2) L: Jack Billingham (10-7) S: Don Stanhouse (20) | First | -- |
| Saturday, September 22 |
| » Lost to Indians (78-75), 7-3 | Memorial Stadium (53-22) | 99-53 | |
| » W: Rick Waits (16-13) L: Scott McGregor (12-6) | First | -- |
| Sunday, September 23 |
| » Lost to Indians (79-75), 4-3 | Memorial Stadium (53-23) | 99-54 | Lost 2 |
| » W: Sid Monge (11-9) L: Dennis Martinez (15-16) | First | -- |
| » Defeated Indians (79-76), 3-1 | Memorial Stadium (54-23) | 100-54 | |
| » W: Mike Flanagan (23-8) L: Dan Spillner (8-5) S: Don Stanhouse (21) | First | -- |
| Tuesday, September 25 |
| » Lost to Tigers (83-73), 3-2 | Memorial Stadium (54-24) | 100-55 | |
| » W: Jack Morris (16-7) L: Tippy Martinez (10-3) S: Aurelio Lopez (21) | First | -- |
| Wednesday, September 26 |
| » Defeated Tigers (83-74), 13-2 | Memorial Stadium (55-24) |
