| Tuesday, March 13 |
| Former Indian Bill Steen dies in Signal Hill, CA at the age of 92. |
| Thursday, March 29 |
| Former Indian Luke Easter dies in Euclid, OH at the age of 64. |
| Tuesday, April 3 |
| Former Indian Harry Simpson dies in Akron, OH at the age of 54. |
| Wednesday, April 4 |
| » Major-league debuts: Mark Clear (Angels) |
| Thursday, April 5 |
| » Lost to Red Sox (1-0), 7-1 | Fenway Park (0-1) | 0-1 | |
| » W: Dennis Eckersley (1-0) L: Rick Wise (0-1) | Third | 1 out |
| Saturday, April 7 |
| » Defeated Red Sox (1-1), 3-0 | Cleveland Stadium (1-0) | 1-1 | |
| » W: Rick Waits (1-0) L: Mike Torrez (0-1) | Second | 1 out |
| Sunday, April 8 |
| » Lost to Red Sox (2-1), 7-6 | Cleveland Stadium (1-1) | 1-2 | |
| » W: Dick Drago (1-0) L: Victor Cruz (0-1) | Second | 1 out |
| » Major-league debuts: Gary Allenson Mike O'Berry and Chuck Rainey (Red Sox) |
| Future Indian Jeremy Guthrie is born in Roseburg, OR. |
| Tuesday, April 10 |
| » Lost to Rangers (2-0), 5-0 | Arlington Stadium (0-1) | 1-3 | Lost 2 |
| » W: Jim Kern (1-0) L: Rick Wise (0-2) | Fourth | 2 out |
| Wednesday, April 11 |
| » Lost to Rangers (3-0), 4-0 | Arlington Stadium (0-2) | 1-4 | Lost 3 |
| » W: Steve Comer (1-0) L: Eric Wilkins (0-1) | Seventh | 2½ out |
| Thursday, April 12 |
| » Lost to Rangers (4-0), 5-3 | Arlington Stadium (0-3) | 1-5 | Lost 4 |
| » W: Fergie Jenkins (2-0) L: Rick Waits (1-1) S: Sparky Lyle (1) | Fifth | 2½ out |
| Sunday, April 15 |
| » Lost to Red Sox (4-2), 14-4 | Fenway Park (0-2) | 1-6 | Lost 5 |
| » W: Dennis Eckersley (2-1) L: Mike Paxton (0-1) S: Dick Drago (1) | Seventh | 4½ out |
| Monday, April 16 |
| » Defeated Red Sox (4-3), 4-3 | Fenway Park (1-2) | 2-6 | |
| » W: Rick Wise (1-2) L: Bob Stanley (0-1) S: Victor Cruz (1) | Seventh | 4 out |
| Tuesday, April 17 |
| » Lost to Rangers (7-1), 6-2 | Cleveland Stadium (1-2) | 2-7 | |
| » W: Fergie Jenkins (3-0) L: Rick Waits (1-2) S: Jim Kern (1) | Seventh | 4 out |
| Wednesday, April 18 |
| » Defeated Rangers (7-2), 6-4 | Cleveland Stadium (2-2) | 3-7 | |
| » W: Sid Monge (1-0) L: Doc Medich (0-1) | Sixth | 4 out |
| Friday, April 20 |
| » Lost to White Sox (6-6), 4-2 | Cleveland Stadium (2-3) | 3-8 | |
| » W: Mike Proly (1-2) L: Victor Cruz (0-2) | Seventh | 4 out |
| Saturday, April 21 |
| » Lost to White Sox (7-6), 6-5 | Cleveland Stadium (2-4) | 3-9 | Lost 2 |
| » W: Ross Baumgarten (1-0) L: Wayne Garland (0-1) S: Mike Proly (3) | Seventh | 5 out |
| Sunday, April 22 |
| » Defeated White Sox (7-7), 8-5 | Cleveland Stadium (3-4) | 4-9 | |
| » W: Rick Waits (2-2) L: Francisco Barrios (1-1) S: Sid Monge (1) | Seventh | 5 out |
| Tuesday, April 24 |
| » Defeated Twins (9-6), 7-2 | Cleveland Stadium (4-4) | 5-9 | Won 2 |
| » W: Rick Wise (2-2) L: Roger Erickson (0-3) | Seventh | 5 out |
| Wednesday, April 25 |
| » Lost to Twins (10-6), 4-2 | Cleveland Stadium (4-5) | 5-10 | |
| » W: Pete Redfern (1-0) L: Sid Monge (1-1) S: Mike Marshall (5) | Seventh | 6 out |
| Thursday, April 26 |
| » Lost to Royals (9-8), 5-4 | Royals Stadium (0-1) | 5-11 | Lost 2 |
| » W: Al Hrabosky (2-0) L: Dan Spillner (0-1) | Seventh | 7 out |
| Friday, April 27 |
| » Lost to Royals (10-8), 15-7 | Royals Stadium (0-2) | 5-12 | Lost 3 |
| » W: Paul Splittorff (3-2) L: Wayne Garland (0-2) S: Eduardo Rodriguez (1) | Sixth | 7 out |
| Saturday, April 28 |
| » Lost to Royals (11-8), 7-2 | Royals Stadium (0-3) | 5-13 | Lost 4 |
| » W: Dennis Leonard (3-2) L: Rick Waits (2-3) | Seventh | 7 out |
| Sunday, April 29 |
| » Defeated Royals (11-9), 5-4 | Royals Stadium (1-3) | 6-13 | |
| » W: Rick Wise (3-2) L: Larry Gura (1-3) S: Sid Monge (2) | Seventh | 7 out |
| Monday, April 30 |
| » Lost to Brewers (13-9), 8-0 | Cleveland Stadium (4-6) | 6-14 | |
| » W: Jim Slaton (2-1) L: Eric Wilkins (0-2) | Seventh | 7 out |
| Tuesday, May 1 |
| » Defeated Brewers (13-10), 3-1 | Cleveland Stadium (5-6) | 7-14 | |
| » W: Mike Paxton (1-1) L: Lary Sorensen (3-3) S: Sid Monge (3) | Sixth | 6½ out |
| Wednesday, May 2 |
| » Lost to Brewers (14-10), 6-1 | Cleveland Stadium (5-7) | 7-15 | |
| » W: Moose Haas (1-1) L: Wayne Garland (0-3) | Sixth | 7½ out |
| Friday, May 4 |
| » Lost to Royals (13-11), 5-4 | Cleveland Stadium (5-8) | 7-16 | Lost 2 |
| » W: Al Hrabosky (3-0) L: Sid Monge (1-2) | Seventh | 8 out |
| Saturday, May 5 |
| » Lost to Royals (14-11), 3-2 | Cleveland Stadium (5-9) | 7-17 | Lost 3 |
| » W: Rich Gale (1-2) L: Rick Wise (3-3) S: Al Hrabosky (4) | Seventh | 9 out |
| Former Indian Virgil Cheeves dies in Dallas, TX at the age of 79. |
| Sunday, May 6 |
| » Defeated Royals (14-12), 5-4 | Cleveland Stadium (6-9) | 8-17 | |
| » W: Mike Paxton (2-1) L: Al Hrabosky (3-1) | Sixth | 9 out |
| Monday, May 7 |
| Former Indian Marty McHale dies in Hempstead, NY at the age of 93. |
| Tuesday, May 8 |
| » Lost to Brewers (18-11), 9-5 | County Stadium (0-1) | 8-18 | |
| » W: Moose Haas (2-1) L: Wayne Garland (0-4) | Sixth | 9½ out |
| Wednesday, May 9 |
| » Defeated Brewers (18-12), 8-7 | County Stadium (1-1) | 9-18 | |
| » W: Rick Waits (3-3) L: Mike Caldwell (4-3) S: Sid Monge (4) | Sixth | 8½ out |
| Thursday, May 10 |
| » Defeated Brewers (18-13), 8-1 | County Stadium (2-1) | 10-18 | Won 2 |
| » W: Eric Wilkins (1-2) L: Jim Slaton (3-2) S: Don Hood (1) | Sixth | 8½ out |
| Friday, May 11 |
| » Lost to Twins (21-8), 4-3 | Metropolitan Stadium (0-1) | 10-19 | |
| » W: Mike Marshall (6-1) L: Sid Monge (1-3) | Sixth | 9½ out |
| Saturday, May 12 |
| » Lost to Twins (22-8), 4-0 | Metropolitan Stadium (0-2) | 10-20 | Lost 2 |
| » W: Jerry Koosman (6-0) L: Mike Paxton (2-2) | Sixth | 10½ out |
| Sunday, May 13 |
| » Defeated Twins (22-9), 3-2 | Metropolitan Stadium (1-2) | 11-20 | |
| » W: Wayne Garland (1-4) L: Dave Goltz (4-4) S: Victor Cruz (2) | Sixth | 10 out |
| Monday, May 14 |
| » Defeated Blue Jays (9-26), 1-0 | Cleveland Stadium (7-9) | 12-20 | Won 2 |
| » W: Rick Waits (4-3) L: Tom Underwood (0-5) | Sixth | 9½ out |
| Tuesday, May 15 |
| » Defeated Blue Jays (9-27), 5-3 | Cleveland Stadium (8-9) | 13-20 | Won 3 |
| » W: Sid Monge (2-3) L: Jerry Garvin (0-1) | Sixth | 9 out |
| Wednesday, May 16 |
| » Lost to Blue Jays (10-27), 4-3 | Cleveland Stadium (8-10) | 13-21 | |
| » W: Dave Lemanczyk (3-2) L: Rick Wise (3-4) | Fifth | 9½ out |
| Thursday, May 17 |
| » Defeated Blue Jays (10-28), 8-3 | Cleveland Stadium (9-10) | 14-21 | |
| » W: Mike Paxton (3-2) L: Mark Lemongello (1-5) | Sixth | 9 out |
| Friday, May 18 |
| » Lost to Tigers (14-17), 5-3 | Cleveland Stadium (9-11) | 14-22 | |
| » W: John Hiller (2-1) L: Sid Monge (2-4) | Sixth | 9½ out |
| Saturday, May 19 |
| » Defeated Tigers (14-18), 6-0 | Cleveland Stadium (10-11) | 15-22 | |
| » W: Rick Waits (5-3) L: Jack Morris (1-1) | Sixth | 9½ out |
| Sunday, May 20 |
| » Defeated Tigers (14-19), 9-7 | Cleveland Stadium (11-11) | 16-22 | Won 2 |
| » W: Dan Spillner (1-1) L: John Hiller (2-2) | Sixth | 9½ out |
| Monday, May 21 |
| » Lost to Blue Jays (11-31), 8-1 | Exhibition Stadium (0-1) | 16-23 | |
| » W: Dave Lemanczyk (4-2) L: Rick Wise (3-5) | Sixth | 10 out |
| » Major-league debuts: Danny Ainge (Blue Jays) |
| Tuesday, May 22 |
| » Defeated Blue Jays (11-32), 8-6 | Exhibition Stadium (1-1) | 17-23 | |
| » W: Eric Wilkins (2-2) L: Mark Lemongello (1-6) S: Sid Monge (5) | Sixth | 9 out |
| Wednesday, May 23 |
| » Defeated Blue Jays (11-33), 4-3 | Exhibition Stadium (2-1) | 18-23 | Won 2 |
| » W: Wayne Garland (2-4) L: Dave Freisleben (1-2) | Sixth | 9 out |
| Saturday, May 26 |
| » Defeated Yankees (23-20), 8-4 | Cleveland Stadium (12-11) | 19-23 | Won 3 |
| » W: Rick Waits (6-3) L: Tommy John (9-1) | Fifth | 9½ out |
| Sunday, May 27 |
| » Defeated Yankees (23-21), 5-0 | Cleveland Stadium (13-11) | 20-23 | Won 4 |
| » W: Rick Wise (4-5) L: Ron Guidry (4-4) | Sixth | 8½ out |
| » Lost to Yankees (24-21), 5-4 | Cleveland Stadium (13-12) | 20-24 | |
| » W: Ray Burris (1-0) L: Sid Monge (2-5) | Sixth | 8½ out |
| Monday, May 28 |
| » Lost to White Sox (23-23), 6-1 | Comiskey Park I (0-1) | 20-25 | Lost 2 |
| » W: Ken Kravec (5-3) L: Wayne Garland (2-5) | Sixth | 8½ out |
| Tuesday, May 29 |
| » Lost to White Sox (24-23), 4-2 | Comiskey Park I (0-2) | 20-26 | Lost 3 |
| » W: Rich Wortham (6-4) L: Eric Wilkins (2-3) S: Randy Scarbery (2) | Sixth | 9½ out |
| Wednesday, May 30 |
| » Defeated White Sox (24-24), 6-4 | Comiskey Park I (1-2) | 21-26 | |
| » W: Rick Waits (7-3) L: Ross Baumgarten (5-2) S: Victor Cruz (3) | Sixth | 8½ out |
| Friday, June 1 |
| » Defeated Angels (30-21), 7-4 | Anaheim Stadium (1-0) | 22-26 | Won 2 |
| » W: Rick Wise (5-5) L: Dave Frost (3-3) S: Victor Cruz (4) | Sixth | 7½ out |
| Saturday, June 2 |
| » Lost to Angels (31-21), 5-2 | Anaheim Stadium (1-1) | 22-27 | |
| » W: Mark Clear (5-1) L: Wayne Garland (2-6) | Sixth | 8½ out |
| Sunday, June 3 |
| » Defeated Angels (31-22), 5-3 | Anaheim Stadium (2-1) | 23-27 | |
| » W: Mike Paxton (4-2) L: Jim Barr (3-1) | Sixth | 7½ out |
| Monday, June 4 |
| » Defeated Athletics (18-36), 5-4 | Oakland-Alameda County Stadium (1-0) | 24-27 | Won 2 |
| » W: Sid Monge (3-5) L: Bob Lacey (1-3) | Sixth | 7½ out |
| Tuesday, June 5 |
| » Defeated Athletics (18-37), 12-3 | Oakland-Alameda County Stadium (2-0) | 25-27 | Won 3 |
| » W: Rick Waits (8-3) L: Rick Langford (1-9) | Sixth | 6½ out |
| Wednesday, June 6 |
| » Defeated Athletics (18-38), 6-4 | Oakland-Alameda County Stadium (3-0) | 26-27 | Won 4 |
| » W: Rick Wise (6-5) L: Dave Heaverlo (2-5) S: Victor Cruz (5) | Sixth | 6½ out |
| Friday, June 8 |
| » Lost to Mariners (23-35), 6-2 | Kingdome (0-1) | 26-28 | |
| » W: Mike Parrott (4-1) L: Wayne Garland (2-7) S: Byron McLaughlin (2) | Sixth | 8 out |
| Saturday, June 9 |
| » Defeated Mariners (23-36), 4-3 | Kingdome (1-1) | 27-28 | |
| » W: Sid Monge (4-5) L: Shane Rawley (2-6) | Fifth | 8 out |
| Sunday, June 10 |
| » Lost to Mariners (24-36), 5-2 | Kingdome (1-2) | 27-29 | |
| » W: Odell Jones (1-6) L: Rick Waits (8-4) S: Shane Rawley (7) | Sixth | 9 out |
| Monday, June 11 |
| » Lost to Angels (36-24), 9-4 | Cleveland Stadium (13-13) | 27-30 | Lost 2 |
| » W: Mark Clear (6-1) L: Dan Spillner (1-2) | Sixth | 10 out |
| Tuesday, June 12 |
| » Defeated Angels (36-25), 11-10 | Cleveland Stadium (14-13) | 28-30 | |
| » W: Don Hood (1-0) L: Mark Clear (6-2) | Sixth | 9 out |
| Former Indian Bill Brenzel dies in Oakland, CA at the age of 70. |
| Wednesday, June 13 |
| » Defeated Athletics (19-43), 6-4 | Cleveland Stadium (15-13) | 29-30 | Won 2 |
| » W: Wayne Garland (3-7) L: Bob Lacey (1-4) | Sixth | 9 out |
| Thursday, June 14 |
| » Defeated Athletics (19-44), 2-1 | Cleveland Stadium (16-13) | 30-30 | Won 3 |
| » W: Sid Monge (5-5) L: Jim Todd (2-3) | Sixth | 8½ out |
| Friday, June 15 |
| » Defeated Mariners (26-39), 13-3 | Cleveland Stadium (17-13) | 31-30 | Won 4 |
| » W: Rick Waits (9-4) L: Odell Jones (1-7) | Sixth | 8½ out |
| Saturday, June 16 |
| » Defeated Mariners (26-40), 4-3 | Cleveland Stadium (18-13) | 32-30 | Won 5 |
| » W: Sid Monge (6-5) L: John Montague (4-1) | Fifth | 8 out |
| Sunday, June 17 |
| » Lost to Mariners (27-40), 6-5 | Cleveland Stadium (18-14) | 32-31 | |
| » W: Shane Rawley (4-6) L: Sid Monge (6-6) S: Byron McLaughlin (4) | Fifth | 9 out |
| Monday, June 18 |
| » Lost to Orioles (42-22), 8-7 | Cleveland Stadium (18-15) | 32-32 | Lost 2 |
| » W: Don Stanhouse (6-1) L: Victor Cruz (0-3) | Sixth | 10 out |
| Former Indian Hal Trosky dies in Cedar Rapids, IA at the age of 67. |
| Tuesday, June 19 |
| » Lost to Orioles (43-22), 6-4 | Cleveland Stadium (18-16) | 32-33 | Lost 3 |
| » W: Tim Stoddard (3-1) L: Mike Paxton (4-3) | Sixth | 11 out |
| Wednesday, June 20 |
| » Lost to Orioles (44-22), 5-3 | Cleveland Stadium (18-17) | 32-34 | Lost 4 |
| » W: Dennis Martinez (10-2) L: Rick Waits (9-5) | Sixth | 12 out |
| Friday, June 22 |
| » Lost to Yankees (37-33), 3-2 | Yankee Stadium (0-1) | 32-35 | Lost 5 |
| » W: Catfish Hunter (1-5) L: Eric Wilkins (2-4) S: Ken Clay (1) | Sixth | 13 out |
| Saturday, June 23 |
| » Lost to Yankees (38-33), 6-5 | Yankee Stadium (0-2) | 32-36 | Lost 6 |
| » W: Tommy John (11-3) L: Victor Cruz (0-4) | Fifth | 14½ out |
| Sunday, June 24 |
| » Lost to Yankees (39-33), 8-2 | Yankee Stadium (0-3) | 32-37 | Lost 7 |
| » W: Jim Kaat (2-0) L: Rick Waits (9-6) S: Ron Davis (3) | Sixth | 14½ out |
| Monday, June 25 |
| » Lost to Orioles (48-23), 3-2 | Memorial Stadium (0-1) | 32-38 | Lost 8 |
| » W: Steve Stone (5-5) L: Wayne Garland (3-8) S: Don Stanhouse (7) | Sixth | 15½ out |
| Tuesday, June 26 |
| » Lost to Orioles (49-23), 4-3 | Memorial Stadium (0-2) | 32-39 | Lost 9 |
| » W: Mike Flanagan (9-5) L: Len Barker (0-1) S: Don Stanhouse (8) | Sixth | 16½ out |
| Wednesday, June 27 |
| » Lost to Orioles (50-23), 3-1 | Memorial Stadium (0-3) | 32-40 | Lost 10 |
| » W: Jim Palmer (7-3) L: Mike Paxton (4-4) | Sixth | 17½ out |
| Thursday, June 28 |
| » Defeated Orioles (50-24), 6-3 | Memorial Stadium (1-3) | 33-40 | |
| » W: Rick Wise (7-5) L: Dennis Martinez (10-4) S: Sid Monge (6) | Sixth | 16½ out |
| Friday, June 29 |
| » Lost to Tigers (35-36), 8-6 | Tiger Stadium (0-1) | 33-41 | |
| » W: Milt Wilcox (6-4) L: Victor Cruz (0-5) S: Dave Tobik (2) | Sixth | 18 out |
| Former Indian Johnny Bassler dies in Santa Monica, CA at the age of 85. |
| Saturday, June 30 |
| » Defeated Tigers (35-37), 4-2 | Tiger Stadium (1-1) | 34-41 | |
| » W: David Clyde (1-0) L: Kip Young (1-1) S: Sid Monge (7) | Sixth | 18 out |
| Sunday, July 1 |
| » Lost to Tigers (36-37), 10-2 | Tiger Stadium (1-2) | 34-42 | |
| » W: Jack Morris (6-4) L: Len Barker (0-2) | Sixth | 19 out |
| Monday, July 2 |
| » Defeated Tigers (36-38), 8-4 | Tiger Stadium (2-2) | 35-42 | |
| » W: Victor Cruz (1-5) L: Aurelio Lopez (3-2) | Sixth | 18 out |
| Tuesday, July 3 |
| » Defeated White Sox (33-45), 7-3 | Cleveland Stadium (19-17) | 36-42 | Won 2 |
| » W: Rick Wise (8-5) L: Ken Kravec (8-7) S: Sid Monge (8) | Sixth | 17 out |
| Wednesday, July 4 |
| » Lost to White Sox (34-45), 16-4 | Cleveland Stadium (19-18) | 36-43 | |
| » W: Ross Baumgarten (7-5) L: Rick Waits (9-7) | Sixth | 17 out |
| » Major-league debuts: Guy Hoffman (White Sox) |
| Thursday, July 5 |
| » Lost to White Sox (35-45), 5-4 | Cleveland Stadium (19-19) | 36-44 | Lost 2 |
| » W: Rich Wortham (8-8) L: Victor Cruz (1-6) S: Guy Hoffman (1) | Sixth | 17½ out |
| Friday, July 6 |
| » Defeated Twins (43-37), 6-5 | Cleveland Stadium (20-19) | 37-44 | |
| » W: Dan Spillner (2-2) L: Paul Hartzell (4-6) S: Sid Monge (9) | Sixth | 16½ out |
| Saturday, July 7 |
| » Defeated Twins (43-38), 9-3 | Cleveland Stadium (21-19) | 38-44 | Won 2 |
| » W: Mike Paxton (5-4) L: Darrell Jackson (1-1) | Sixth | 15½ out |
| Sunday, July 8 |
| » Defeated Twins (43-39), 5-4 | Cleveland Stadium (22-19) | 39-44 | Won 3 |
| » W: Victor Cruz (2-6) L: Mike Marshall (9-8) | Sixth | 16 out |
| » Lost to Twins (44-39), 7-2 | Cleveland Stadium (22-20) | 39-45 | |
| » W: Dave Goltz (7-6) L: Rick Waits (9-8) | Sixth | 16 out |
| Monday, July 9 |
| » Defeated Royals (43-42), 8-2 | Cleveland Stadium (23-20) | 40-45 | |
| » W: David Clyde (2-0) L: Dennis Leonard (5-5) | Sixth | 16 out |
| Tuesday, July 10 |
| » Defeated Royals (43-43), 7-4 | Cleveland Stadium (24-20) | 41-45 | Won 2 |
| » W: Dan Spillner (3-2) L: Rich Gale (6-7) S: Victor Cruz (6) | Sixth | 15 out |
| Wednesday, July 11 |
| » Defeated Royals (43-44), 9-8 | Cleveland Stadium (25-20) | 42-45 | Won 3 |
| » W: Mike Paxton (6-4) L: Paul Splittorff (9-8) S: Victor Cruz (7) | Fifth | 15 out |
| Friday, July 13 |
| » Lost to Brewers (52-38), 4-3 | County Stadium (2-2) | 42-46 | |
| » W: Bob Galasso (1-0) L: Victor Cruz (2-7) | Sixth | 15 out |
| Saturday, July 14 |
| » Lost to Brewers (53-38), 10-3 | County Stadium (2-3) | 42-47 | Lost 2 |
| » W: Bill Travers (7-4) L: David Clyde (2-1) S: Reggie Cleveland (3) | Sixth | 16 out |
| Sunday, July 15 |
| » Lost to Brewers (54-38), 10-4 | County Stadium (2-4) | 42-48 | Lost 3 |
| » W: Lary Sorensen (11-9) L: Len Barker (0-3) | Sixth | 17 out |
| Thursday, July 19 |
| » Defeated Royals (44-48), 2-1 | Royals Stadium (2-3) | 43-48 | |
| » W: Rick Wise (9-5) L: Dennis Leonard (5-7) S: Sid Monge (10) | Sixth | 16½ out |
| Friday, July 20 |
| » Lost to Royals (45-48), 9-1 | Royals Stadium (2-4) | 43-49 | |
| » W: Rich Gale (7-8) L: Rick Waits (9-9) | Sixth | 17½ out |
| Saturday, July 21 |
| » Lost to Brewers (57-38), 5-0 | Cleveland Stadium (25-21) | 43-50 | Lost 2 |
| » W: Moose Haas (7-6) L: Len Barker (0-4) | Sixth | 18½ out |
| Sunday, July 22 |
| » Lost to Brewers (58-38), 14-5 | Cleveland Stadium (25-22) | 43-51 | Lost 3 |
| » W: Mike Caldwell (11-5) L: Mike Paxton (6-5) S: Reggie Cleveland (4) | Sixth | 20 out |
| » Lost to Brewers (59-38), 5-3 | Cleveland Stadium (25-23) | 43-52 | Lost 4 |
| » W: Paul Mitchell (2-6) L: David Clyde (2-2) S: Bill Castro (2) | Sixth | 20 out |
| Monday, July 23 |
| » Defeated Brewers (59-39), 5-4 | Cleveland Stadium (26-23) | 44-52 | |
| » Manager: Dave Garcia |
| » W: Dan Spillner (4-2) L: Lary Sorensen (11-10) S: Sid Monge (11) | Sixth | 20 out |
| Tuesday, July 24 |
| » Defeated Twins (53-43), 4-2 | Metropolitan Stadium (2-2) | 45-52 | Won 2 |
| » W: Rick Wise (10-5) L: Jerry Koosman (11-9) | Sixth | 20½ out |
| Wednesday, July 25 |
| » Defeated Twins (53-44), 2-0 | Metropolitan Stadium (3-2) | 46-52 | Won 3 |
| » W: Rick Waits (10-9) L: Dave Goltz (9-7) | Sixth | 19½ out |
| Thursday, July 26 |
| » Defeated Twins (53-45), 7-2 | Metropolitan Stadium (4-2) | 47-52 | Won 4 |
| » W: Dan Spillner (5-2) L: Pete Redfern (5-1) S: Sid Monge (12) | Sixth | 19½ out |
| Friday, July 27 |
| » Defeated White Sox (46-54), 7-2 | Comiskey Park I (2-2) | 48-52 | Won 5 |
| » W: David Clyde (3-2) L: Randy Scarbery (1-5) | Sixth | 19½ out |
| Saturday, July 28 |
| » Defeated White Sox (46-55), 10-5 | Comiskey Park I (3-2) | 49-52 | Won 6 |
| » W: Mike Paxton (7-5) L: Steve Trout (5-4) S: Victor Cruz (8) | Sixth | 18½ out |
| Sunday, July 29 |
| » Defeated White Sox (46-56), 9-6 | Comiskey Park I (4-2) | 50-52 | Won 7 |
| » W: Rick Wise (11-5) L: Ken Kravec (9-9) S: Paul Reuschel (1) | Sixth | 18½ out |
| Monday, July 30 |
| » Defeated Red Sox (62-38), 6-5 | Cleveland Stadium (27-23) | 51-52 | Won 8 |
| » W: Victor Cruz (3-7) L: Tom Burgmeier (2-1) | Sixth | 18½ out |
| Tuesday, July 31 |
| » Defeated Red Sox (62-39), 11-10 | Cleveland Stadium (28-23) | 52-52 | Won 9 |
| » W: Sid Monge (7-6) L: Bill Campbell (3-4) | Sixth | 18 out |
| » Defeated Red Sox (62-40), 3-0 | Cleveland Stadium (29-23) | 53-52 | Won 10 |
| » W: Len Barker (1-4) L: Joel Finch (0-3) S: Sid Monge (13) | Sixth | 18 out |
| Wednesday, August 1 |
| » Lost to Red Sox (63-40), 7-4 | Cleveland Stadium (29-24) | 53-53 | |
| » W: Dennis Eckersley (13-5) L: David Clyde (3-3) | Sixth | 19 out |
| Friday, August 3 |
| » Lost to Rangers (57-49), 8-3 | Cleveland Stadium (29-25) | 53-54 | Lost 2 |
| » W: Fergie Jenkins (11-8) L: Rick Wise (11-6) | Sixth | 20 out |
| Saturday, August 4 |
| » Defeated Rangers (57-50), 12-8 | Cleveland Stadium (30-25) | 54-54 | |
| » W: Rick Waits (11-9) L: John Henry Johnson (4-13) S: Dan Spillner (1) | Sixth | 20 out |
| Sunday, August 5 |
| » Defeated Rangers (57-51), 6-2 | Cleveland Stadium (31-25) | 55-54 | Won 2 |
| » W: Len Barker (2-4) L: Doc Medich (5-5) | Sixth | 19½ out |
| » Lost to Rangers (58-51), 14-3 | Cleveland Stadium (31-26) | 55-55 | |
| » W: Danny Darwin (3-2) L: Mike Paxton (7-6) | Sixth | 19½ out |
| Tuesday, August 7 |
| » Lost to Red Sox (68-41), 12-3 | Fenway Park (1-3) | 55-56 | Lost 2 |
| » W: Mike Torrez (13-6) L: David Clyde (3-4) | Sixth | 19 out |
| Wednesday, August 8 |
| » Defeated Red Sox (68-42), 6-4 | Fenway Park (2-3) | 56-56 | |
| » W: Rick Wise (12-6) L: Bob Stanley (11-8) S: Sid Monge (14) | Sixth | 17½ out |
| » Defeated Red Sox (68-43), 8-2 | Fenway Park (3-3) | 57-56 | Won 2 |
| » W: Dan Spillner (6-2) L: Steve Renko (8-7) | Sixth | 17½ out |
| Thursday, August 9 |
| » Lost to Red Sox (69-43), 3-2 | Fenway Park (3-4) | 57-57 | |
| » W: Dennis Eckersley (15-5) L: Rick Waits (11-10) | Sixth | 18½ out |
| Friday, August 10 |
| » Defeated Rangers (59-56), 6-1 | Arlington Stadium (1-3) | 58-57 | |
| » W: Len Barker (3-4) L: Danny Darwin (3-3) | Sixth | 18½ out |
| Saturday, August 11 |
| » Lost to Rangers (60-56), 5-2 | Arlington Stadium (1-4) | 58-58 | |
| » W: Brian Allard (1-0) L: Mike Paxton (7-7) S: Jim Kern (19) | Sixth | 19 out |
| Sunday, August 12 |
| » Defeated Rangers (60-57), 6-3 | Arlington Stadium (2-4) | 59-58 | |
| » W: Dan Spillner (7-2) L: Steve Comer (12-7) S: Sid Monge (15) | Fifth | 18½ out |
| Monday, August 13 |
| » Defeated Mariners (49-70), 6-0 | Kingdome (2-2) | 60-58 | Won 2 |
| » W: Rick Wise (13-6) L: Floyd Bannister (6-12) | Fifth | 17½ out |
| Tuesday, August 14 |
| » Defeated Mariners (49-71), 7-4 | Kingdome (3-2) | 61-58 | Won 3 |
| » W: Rick Waits (12-10) L: Odell Jones (3-11) S: Sid Monge (16) | Fifth | 17½ out |
| Wednesday, August 15 |
| » Lost to Mariners (50-71), 3-2 | Kingdome (3-3) | 61-59 | |
| » W: Mike Parrott (10-8) L: Sid Monge (7-7) | Sixth | 18½ out |
| Thursday, August 16 |
| » Major-league debuts: John Tudor (Red Sox) |
| Friday, August 17 |
| » Lost to Athletics (37-85), 5-3 | Oakland-Alameda County Stadium (3-1) | 61-60 | Lost 2 |
| » W: Steve McCatty (8-7) L: Dan Spillner (7-3) | Sixth | 18 out |
| Saturday, August 18 |
| » Lost to Athletics (38-85), 4-1 | Oakland-Alameda County Stadium (3-2) | 61-61 | Lost 3 |
| » W: Rick Langford (8-13) L: Rick Wise (13-7) | Sixth | 19 out |
| Sunday, August 19 |
| » Lost to Athletics (39-85), 3-2 | Oakland-Alameda County Stadium (3-3) | 61-62 | Lost 4 |
| » W: Mike Norris (4-5) L: Rick Waits (12-11) | Sixth | 19 out |
| Monday, August 20 |
| » Lost to Angels (70-55), 6-5 | Anaheim Stadium (2-2) | 61-63 | Lost 5 |
| » W: Dave LaRoche (5-10) L: Sid Monge (7-8) | Sixth | 20 out |
| Tuesday, August 21 |
| » Defeated Angels (70-56), 12-7 | Anaheim Stadium (3-2) | 62-63 | |
| » W: Paul Reuschel (1-0) L: Dave Frost (12-8) | Sixth | 19 out |
| » Major-league debuts: Bobby Clark (Angels) |
| Wednesday, August 22 |
| » Defeated Angels (70-57), 13-3 | Anaheim Stadium (4-2) | 63-63 | Won 2 |
| » W: Dan Spillner (8-3) L: Nolan Ryan (13-9) | Sixth | 18½ out |
| Thursday, August 23 |
| » Lost to Athletics (41-87), 8-6 | Cleveland Stadium (31-27) | 63-64 | |
| » W: Rick Langford (9-13) L: Sid Monge (7-9) | Sixth | 19½ out |
| Friday, August 24 |
| » Defeated Athletics (41-88), 5-2 | Cleveland Stadium (32-27) | 64-64 | |
| » W: Rick Waits (13-11) L: Mike Norris (4-6) | Sixth | 19 out |
| Saturday, August 25 |
| » Defeated Athletics (41-89), 5-3 | Cleveland Stadium (33-27) | 65-64 | Won 2 |
| » W: Len Barker (4-4) L: Mike Morgan (2-7) S: Victor Cruz (9) | Sixth | 18½ out |
| Sunday, August 26 |
| » Defeated Athletics (41-90), 7-5 | Cleveland Stadium (34-27) | 66-64 | Won 3 |
| » W: Wayne Garland (4-8) L: Brian Kingman (4-5) S: Sid Monge (17) | Sixth | 19 out |
| Monday, August 27 |
| » Lost to Mariners (56-76), 6-5 | Cleveland Stadium (34-28) | 66-65 | |
| » W: Byron McLaughlin (6-4) L: Victor Cruz (3-8) | Sixth | 19½ out |
| Wednesday, August 29 |
| » Defeated Mariners (56-77), 5-4 | Cleveland Stadium (35-28) | 67-65 | |
| » W: Sid Monge (8-9) L: Shane Rawley (5-7) | Sixth | 19½ out |
| » Defeated Mariners (56-78), 2-1 | Cleveland Stadium (36-28) | 68-65 | Won 2 |
| » W: Rick Waits (14-11) L: Wayne Twitchell (5-4) S: Victor Cruz (10) | Sixth | 19½ out |
| Thursday, August 30 |
| » Defeated Angels (71-63), 7-1 | Cleveland Stadium (37-28) | 69-65 | Won 3 |
| » W: Len Barker (5-4) L: Nolan Ryan (13-11) | Sixth | 19½ out |
| Friday, August 31 |
| » Lost to Angels (72-63), 9-8 | Cleveland Stadium (37-29) | 69-66 | |
| » W: Mark Clear (11-4) L: Paul Reuschel (1-1) S: John Montague (2) | Sixth | 19½ out |
| Saturday, September 1 |
| » Lost to Angels (73-63), 7-4 | Cleveland Stadium (37-30) | 69-67 | Lost 2 |
| » W: Dave LaRoche (6-10) L: Wayne Garland (4-9) S: John Montague (3) | Sixth | 19½ out |
| Sunday, September 2 |
| » Lost to Angels (74-63), 5-2 | Cleveland Stadium (37-31) | 69-68 | Lost 3 |
| » W: Dave Frost (14-9) L: Rick Waits (14-12) S: Mark Clear (14) | Sixth | 20½ out |
| Monday, September 3 |
| » Defeated Tigers (72-65), 4-3 | Cleveland Stadium (38-31) | 70-68 | |
| » W: Rick Wise (14-7) L: Jack Morris (13-6) | Sixth | 21 out |
| Tuesday, September 4 |
| » Defeated Tigers (72-66), 5-3 | Cleveland Stadium (39-31) | 71-68 | Won 2 |
| » W: Len Barker (6-4) L: Dan Petry (5-5) S: Sid Monge (18) | Sixth | 20½ out |
| Wednesday, September 5 |
| » Lost to Tigers (73-66), 9-3 | Cleveland Stadium (39-32) | 71-69 | |
| » W: Aurelio Lopez (8-4) L: Victor Cruz (3-9) | Sixth | 21 out |
| Future Indian Cliff Bartosh is born in West, TX. |
| Friday, September 7 |
| » Defeated Blue Jays (44-96), 9-8 | Cleveland Stadium (40-32) | 72-69 | |
| » W: Paul Reuschel (2-1) L: Tom Buskey (6-8) | Sixth | 21½ out |
| Saturday, September 8 |
| » Defeated Blue Jays (44-97), 5-4 | Cleveland Stadium (41-32) | 73-69 | Won 2 |
| » W: Rick Wise (15-7) L: Dave Stieb (6-6) | Sixth | 21½ out |
| Sunday, September 9 |
| » Defeated Blue Jays (44-98), 14-10 | Cleveland Stadium (42-32) | 74-69 | Won 3 |
| » W: Sid Monge (9-9) L: Tom Buskey (6-9) | Sixth | 21½ out |
| Tuesday, September 11 |
| » Lost to Tigers (76-68), 14-1 | Tiger Stadium (2-3) | 74-70 | |
| » W: Dave Rozema (4-3) L: Dan Spillner (8-4) | Sixth | 21 out |
| Wednesday, September 12 |
| » Lost to Tigers (77-68), 4-1 | Tiger Stadium (2-4) | 74-71 | Lost 2 |
| » W: Milt Wilcox (12-7) L: Rick Waits (14-13) S: Aurelio Lopez (18) | Sixth | 21 out |
| Friday, September 14 |
| » Lost to Blue Jays (47-99), 4-3 | Exhibition Stadium (2-2) | 74-72 | Lost 3 |
| » W: Dave Stieb (7-6) L: Rick Wise (15-8) | Sixth | 22½ out |
| Saturday, September 15 |
| » Lost to Blue Jays (48-99), 5-2 | Exhibition Stadium (2-3) | 74-73 | Lost 4 |
| » W: Balor Moore (4-6) L: Len Barker (6-5) | Sixth | 22½ out |
| Sunday, September 16 |
| » Lost to Blue Jays (49-99), 8-2 | Exhibition Stadium (2-4) | 74-74 | Lost 5 |
| » W: Tom Underwood (8-16) L: Wayne Garland (4-10) | Sixth | 23½ out |
| Monday, September 17 |
| » Defeated Yankees (80-67), 5-1 | Cleveland Stadium (43-32) | 75-74 | |
| » W: Rick Waits (15-13) L: Jim Beattie (3-6) | Sixth | 23 out |
| » Defeated Yankees (80-68), 6-5 | Cleveland Stadium (44-32) | 76-74 | Won 2 |
| » W: Sid Monge (10-9) L: Don Hood (4-1) | Sixth | 23 out |
| » Major-league debuts: Mike Griffin and Dennis Werth (Yankees) |
| Tuesday, September 18 |
| » Defeated Yankees (80-69), 16-3 | Cleveland Stadium (45-32) | 77-74 | Won 3 |
| » W: Mike Paxton (8-7) L: Paul Mirabella (0-4) | Sixth | 22 out |
| » Major-league debuts: Rick Anderson (Yankees) |
| Future Indian Billy Traber is born in Torrance, CA. |
| Wednesday, September 19 |
| » Lost to Yankees (81-69), 2-0 | Cleveland Stadium (45-33) | 77-75 | |
| » W: Tommy John (19-9) L: Rick Wise (15-9) S: Ron Davis (9) | Sixth | 22 out |
| Saturday, September 22 |
| » Defeated Orioles (99-53), 7-3 | Memorial Stadium (2-3) | 78-75 | |
| » W: Rick Waits (16-13) L: Scott McGregor (12-6) | Sixth | 21½ out |
| Sunday, September 23 |
| » Defeated Orioles (99-54), 4-3 | Memorial Stadium (3-3) | 79-75 | Won 2 |
| » W: Sid Monge (11-9) L: Dennis Martinez (15-16) | Sixth | 21½ out |
| » Lost to Orioles (100-54), 3-1 | Memorial Stadium (3-4) | 79-76 | |
| » W: Mike Flanagan (23-8) L: Dan Spillner (8-5) S: Don Stanhouse (21) | Sixth | 21½ out |
| Tuesday, September 25 |
| » Lost to Yankees (84-71), 7-5 | Yankee Stadium (0-4) | 79-77 | Lost 2 |
| » W: Ron Davis (13-2) L: Rick Wise (15-10) S: Rich Gossage (18) | Sixth | 21½ out |
| Wednesday, September 26 |
| » Lost to Yankees (85-71), 6-3 | Yankee Stadium (0-5) | 79-78 | Lost 3 |
| » W: Ron Guidry (18-8) L: Mike Paxton (8-8) | Sixth | 22½ out |
| Thursday, September 27 |
| » Lost to Yankees (86-71), 5-2 | Yankee Stadium (0-6) | 79-79 | Lost 4 |
| » W: Rich Gossage (5-3) L: Sid Monge (11-10) | Sixth | 23 out |
| Friday, September 28 |
| » Lost to Orioles (102-55), 14-6 | Cleveland Stadium (45-34) | 79-80 | Lost 5 |
| » W: Jim Palmer (10-6) L: Len Barker (6-6) | Sixth | 24 out |
| Saturday, September 29 |
| » Defeated Orioles (102-56), 4-1 | Cleveland Stadium (46-34) | 80-80 | |
| » W: Dan Spillner (9-5) L: Mike Flanagan (23-9) S: Sid Monge (19) | Sixth | 23 out |
| Sunday, September 30 |
| » Defeated Orioles (102-57), 6-5 | Cleveland Stadium (47-34) | 81-80 | Won 2 |
| » W: Sid Monge (12-10) L: Dave Ford (2-1) | Sixth | 22 out |
| Thursday, October 11 |
| Former Indian Abe Bowman dies in Longview, TX at the age of 87. |
| Thursday, November 1 |
| Future Indian Coco Crisp is born in Los Angeles, CA. |
| Thursday, November 15 |
| Former Indian Eddie Klieman dies in Homosassa, FL at the age of 62. |
Game information provided by Retrosheet (www.retrosheet.org) |