| Sunday, January 21 |
| Former Giant Sam Leslie dies in Pascagoula, MS at the age of 74. |
| Monday, January 29 |
| Future Giant Lance Niekro is born in Winter Haven, FL. |
| Thursday, February 8 |
| Former Giant Alex Gaston dies in Santa Monica, CA at the age of 86. |
| Wednesday, April 4 |
| » Defeated Reds (0-1), 11-5 | Riverfront Stadium (1-0) | 1-0 | |
| » W: Vida Blue (1-0) L: Tom Seaver (0-1) | First | -- |
| » Major-league debuts: Frank Pastore (Reds) |
| Friday, April 6 |
| » Defeated Reds (0-2), 7-2 | Riverfront Stadium (2-0) | 2-0 | Won 2 |
| » W: John Montefusco (1-0) L: Tom Hume (0-1) S: Gary Lavelle (1) | First | -- |
| Saturday, April 7 |
| » Defeated Reds (0-3), 4-2 | Riverfront Stadium (3-0) | 3-0 | Won 3 |
| » W: Tom Griffin (1-0) L: Frank Pastore (0-1) S: Dave Roberts (1) | First | -- |
| Sunday, April 8 |
| » Lost to Reds (1-3), 7-6 | Riverfront Stadium (3-1) | 3-1 | |
| » W: Doug Bair (1-0) L: John Curtis (0-1) | Second | ½ out |
| » Major-league debuts: Max Venable (Giants) |
| Tuesday, April 10 |
| » Defeated Padres (1-4), 4-2 | Candlestick Park (1-0) | 4-1 | |
| » W: Vida Blue (2-0) L: John D'Acquisto (0-1) | First | -- |
| Wednesday, April 11 |
| » Lost to Padres (2-4), 4-1 | Candlestick Park (1-1) | 4-2 | |
| » W: Randy Jones (1-1) L: John Montefusco (1-1) S: Rollie Fingers (2) | Second | 1 out |
| Thursday, April 12 |
| » Defeated Padres (2-5), 4-3 | Candlestick Park (2-1) | 5-2 | |
| » W: Bob Knepper (1-0) L: Eric Rasmussen (0-2) S: Dave Roberts (2) | Second | ½ out |
| Friday, April 13 |
| » Defeated Astros (5-2), 8-7 | Candlestick Park (3-1) | 6-2 | Won 2 |
| » W: Ed Halicki (1-0) L: Joe Niekro (1-1) S: Gary Lavelle (2) | First | -- |
| » Major-league debuts: Gary Wilson (Astros) |
| Saturday, April 14 |
| » Defeated Astros (5-3), 2-1 | Candlestick Park (4-1) | 7-2 | Won 3 |
| » W: Vida Blue (3-0) L: Vern Ruhle (0-2) | First | -- |
| Sunday, April 15 |
| » Lost to Astros (6-3), 4-3 | Candlestick Park (4-2) | 7-3 | |
| » W: J.R. Richard (3-0) L: John Montefusco (1-2) S: Joe Sambito (1) | Second | ½ out |
| » Lost to Astros (7-3), 9-1 | Candlestick Park (4-3) | 7-4 | Lost 2 |
| » W: Joaquin Andujar (1-0) L: Tom Griffin (1-1) | Second | ½ out |
| Tuesday, April 17 |
| » Lost to Padres (5-7), 4-3 | San Diego/Jack Murphy Stadium (0-1) | 7-5 | Lost 3 |
| » W: Rollie Fingers (1-0) L: Bob Knepper (1-1) | Second | 1 out |
| Wednesday, April 18 |
| » Lost to Padres (6-7), 7-6 | San Diego/Jack Murphy Stadium (0-2) | 7-6 | Lost 4 |
| » W: Steve Mura (1-0) L: Tom Griffin (1-2) | Second | 2 out |
| Thursday, April 19 |
| » Defeated Padres (6-8), 14-10 | San Diego/Jack Murphy Stadium (1-2) | 8-6 | |
| » W: Vida Blue (4-0) L: Mickey Lolich (0-1) | Second | 1½ out |
| Friday, April 20 |
| » Defeated Dodgers (6-9), 3-2 | Candlestick Park (5-3) | 9-6 | Won 2 |
| » W: Gary Lavelle (1-0) L: Jerry Reuss (1-1) | Second | 1½ out |
| Saturday, April 21 |
| » Lost to Dodgers (7-9), 2-1 | Candlestick Park (5-4) | 9-7 | |
| » W: Burt Hooton (1-2) L: Tom Griffin (1-3) | Third | 2½ out |
| Sunday, April 22 |
| » Lost to Dodgers (8-9), 9-2 | Candlestick Park (5-5) | 9-8 | Lost 2 |
| » W: Don Sutton (2-2) L: Ed Halicki (1-1) | Third | 3½ out |
| Tuesday, April 24 |
| » Lost to Mets (5-8), 10-3 | Shea Stadium (0-1) | 9-9 | Lost 3 |
| » W: Mike Scott (1-0) L: Vida Blue (4-1) | Third | 4 out |
| Wednesday, April 25 |
| » Lost to Mets (6-8), 2-0 | Shea Stadium (0-2) | 9-10 | Lost 4 |
| » W: Craig Swan (2-2) L: Tom Griffin (1-4) | Third | 4 out |
| Friday, April 27 |
| » Lost to Expos (11-5), 14-8 | Stade Olympique (0-1) | 9-11 | Lost 5 |
| » W: Bill Lee (2-0) L: Bob Knepper (1-2) | Third | 5½ out |
| Former Giant Jim Mooney dies in Johnson City, TN at the age of 73. |
| Saturday, April 28 |
| » Lost to Expos (12-5), 6-4 | Stade Olympique (0-2) | 9-12 | Lost 6 |
| » W: Scott Sanderson (1-1) L: Ed Halicki (1-2) S: Elias Sosa (2) | Third | 6 out |
| Sunday, April 29 |
| » Lost to Expos (13-5), 7-5 | Stade Olympique (0-3) | 9-13 | Lost 7 |
| » W: Dan Schatzeder (1-0) L: Vida Blue (4-2) | Fourth | 6 out |
| Monday, April 30 |
| » Lost to Phillies (14-5), 4-1 | Veteran's Stadium (0-1) | 9-14 | Lost 8 |
| » W: Dick Ruthven (4-0) L: Philip Nastu (0-1) S: Tug McGraw (3) | Fourth | 7 out |
| Former Giant Wally Kopf dies in Hamilton Co., OH at the age of 80. |
| Tuesday, May 1 |
| » Defeated Phillies (14-6), 7-0 | Veteran's Stadium (1-1) | 10-14 | |
| » W: Bob Knepper (2-2) L: Nino Espinosa (3-1) | Third | 6 out |
| Thursday, May 3 |
| » Defeated Mets (8-12), 7-5 | Candlestick Park (6-5) | 11-14 | Won 2 |
| » W: Ed Halicki (2-2) L: Pete Falcone (0-2) S: Gary Lavelle (3) | Third | 5½ out |
| Friday, May 4 |
| » Defeated Mets (8-13), 4-3 | Candlestick Park (7-5) | 12-14 | Won 3 |
| » W: Vida Blue (5-2) L: Skip Lockwood (0-3) | Third | 4½ out |
| Saturday, May 5 |
| » Defeated Mets (8-14), 6-4 | Candlestick Park (8-5) | 13-14 | Won 4 |
| » W: Gary Lavelle (2-0) L: Jesse Orosco (1-1) | Third | 3½ out |
| Former Giant Virgil Cheeves dies in Dallas, TX at the age of 79. |
| Sunday, May 6 |
| » Lost to Mets (9-14), 5-4 | Candlestick Park (8-6) | 13-15 | |
| » W: Dale Murray (2-3) L: Randy Moffitt (0-1) S: Skip Lockwood (5) | Third | 4 out |
| Tuesday, May 8 |
| » Lost to Expos (18-7), 4-0 | Candlestick Park (8-7) | 13-16 | Lost 2 |
| » W: Scott Sanderson (2-2) L: Ed Halicki (2-3) | Third | 4 out |
| Wednesday, May 9 |
| » Defeated Expos (18-8), 9-2 | Candlestick Park (9-7) | 14-16 | |
| » W: Vida Blue (6-2) L: Ross Grimsley (3-1) | Third | 4 out |
| Thursday, May 10 |
| » Lost to Expos (19-8), 3-0 | Candlestick Park (9-8) | 14-17 | |
| » W: Steve Rogers (3-1) L: Philip Nastu (0-2) | Fourth | 4 out |
| Friday, May 11 |
| » Defeated Phillies (21-8), 2-1 | Candlestick Park (10-8) | 15-17 | |
| » W: Bob Knepper (3-2) L: Steve Carlton (3-5) S: Gary Lavelle (4) | Fourth | 3½ out |
| Saturday, May 12 |
| » Defeated Phillies (21-9), 4-1 | Candlestick Park (11-8) | 16-17 | Won 2 |
| » W: Ed Halicki (3-3) L: Randy Lerch (2-2) | Fourth | 2½ out |
| Former Giant Clyde Kluttz dies in Salisbury, NC at the age of 62. |
| Sunday, May 13 |
| » Lost to Phillies (22-9), 12-3 | Candlestick Park (11-9) | 16-18 | |
| » W: Ron Reed (4-1) L: Vida Blue (6-3) | Fourth | 3½ out |
| Tuesday, May 15 |
| » Defeated Astros (20-16), 8-1 | Astrodome (1-0) | 17-18 | |
| » W: Philip Nastu (1-2) L: J.R. Richard (4-3) | Fourth | 3 out |
| Wednesday, May 16 |
| » Defeated Astros (20-17), 8-4 | Astrodome (2-0) | 18-18 | Won 2 |
| » W: Gary Lavelle (3-0) L: Bo McLaughlin (1-1) | Third | 3 out |
| Thursday, May 17 |
| » Defeated Astros (20-18), 3-0 | Astrodome (3-0) | 19-18 | Won 3 |
| » W: Ed Halicki (4-3) L: Ken Forsch (4-3) | Third | 2½ out |
| Friday, May 18 |
| » Lost to Braves (13-22), 6-4 | Atlanta-Fulton County Stadium (0-1) | 19-19 | |
| » W: Mickey Mahler (1-3) L: Vida Blue (6-4) S: Gene Garber (7) | Third | 3½ out |
| Saturday, May 19 |
| » Defeated Braves (13-23), 4-2 | Atlanta-Fulton County Stadium (1-1) | 20-19 | |
| » W: Tom Griffin (2-4) L: Craig Skok (0-1) S: Gary Lavelle (5) | Second | 3 out |
| » Defeated Braves (13-24), 7-6 | Atlanta-Fulton County Stadium (2-1) | 21-19 | Won 2 |
| » W: John Curtis (1-1) L: Gene Garber (1-7) S: Tom Griffin (1) | Second | 3 out |
| » Major-league debuts: Tony Brizzolara (Braves) |
| Sunday, May 20 |
| » Defeated Braves (13-25), 8-1 | Atlanta-Fulton County Stadium (3-1) | 22-19 | Won 3 |
| » W: Bob Knepper (4-2) L: Eddie Solomon (3-2) | Third | 2 out |
| Tuesday, May 22 |
| » Defeated Reds (23-17), 12-2 | Candlestick Park (12-9) | 23-19 | Won 4 |
| » W: Ed Halicki (5-3) L: Bill Bonham (2-1) | Second | 1 out |
| Wednesday, May 23 |
| » Lost to Reds (24-17), 5-0 | Candlestick Park (12-10) | 23-20 | |
| » W: Mike LaCoss (5-0) L: Vida Blue (6-5) | Second | 2 out |
| Thursday, May 24 |
| » Defeated Reds (24-18), 2-1 | Candlestick Park (13-10) | 24-20 | |
| » W: Philip Nastu (2-2) L: Paul Moskau (4-1) S: Randy Moffitt (1) | Second | 1 out |
| Friday, May 25 |
| » Defeated Braves (15-27), 6-4 | Candlestick Park (14-10) | 25-20 | Won 2 |
| » W: Bob Knepper (5-2) L: Phil Niekro (5-7) S: Gary Lavelle (6) | Second | 1 out |
| Future Giant Trey Lunsford is born in Odessa, TX. |
| Saturday, May 26 |
| » Lost to Braves (16-27), 5-4 | Candlestick Park (14-11) | 25-21 | |
| » W: Gene Garber (2-7) L: Dave Roberts (0-1) S: Craig Skok (1) | Second | 1 out |
| Sunday, May 27 |
| » Lost to Braves (17-27), 10-8 | Candlestick Park (14-12) | 25-22 | Lost 2 |
| » W: Craig Skok (1-1) L: Randy Moffitt (0-2) S: Gene Garber (10) | Third | 1 out |
| Monday, May 28 |
| » Lost to Braves (18-27), 4-1 | Candlestick Park (14-13) | 25-23 | Lost 3 |
| » W: Mickey Mahler (2-4) L: Philip Nastu (2-3) | Third | 2 out |
| Tuesday, May 29 |
| » Lost to Dodgers (24-26), 6-5 | Dodger Stadium (0-1) | 25-24 | Lost 4 |
| » W: Terry Forster (1-0) L: Gary Lavelle (3-1) | Third | 2 out |
| Wednesday, May 30 |
| » Lost to Dodgers (25-26), 6-5 | Dodger Stadium (0-2) | 25-25 | Lost 5 |
| » W: Jerry Reuss (2-4) L: Gary Lavelle (3-2) S: Lerrin LaGrow (2) | Third | 2½ out |
| Thursday, May 31 |
| » Lost to Dodgers (26-26), 12-10 | Dodger Stadium (0-3) | 25-26 | Lost 6 |
| » W: Don Sutton (6-4) L: Vida Blue (6-6) S: Bob Welch (5) | Fourth | 3½ out |
| Friday, June 1 |
| » Lost to Cubs (21-25), 8-2 | Wrigley Field (0-1) | 25-27 | Lost 7 |
| » W: Rick Reuschel (3-5) L: Philip Nastu (2-4) | Fourth | 4½ out |
| Saturday, June 2 |
| » Defeated Cubs (21-26), 8-6 | Wrigley Field (1-1) | 26-27 | |
| » W: Randy Moffitt (1-2) L: Dick Tidrow (3-2) S: Gary Lavelle (7) | Third | 4½ out |
| Sunday, June 3 |
| » Lost to Cubs (22-26), 2-1 | Wrigley Field (1-2) | 26-28 | |
| » W: Mike Krukow (2-4) L: John Curtis (1-2) S: Bruce Sutter (10) | Third | 5½ out |
| Tuesday, June 5 |
| » Lost to Cardinals (28-20), 5-4 | Busch Stadium II (0-1) | 26-29 | Lost 2 |
| » W: Mark Littell (4-1) L: Randy Moffitt (1-3) | Fourth | 6 out |
| Wednesday, June 6 |
| » Lost to Cardinals (29-20), 6-5 | Busch Stadium II (0-2) | 26-30 | Lost 3 |
| » W: Buddy Schultz (4-2) L: Randy Moffitt (1-4) S: Mark Littell (4) | Fourth | 7 out |
| Thursday, June 7 |
| » Defeated Cardinals (29-21), 12-10 | Busch Stadium II (1-2) | 27-30 | |
| » W: Tom Griffin (3-4) L: Mark Littell (4-2) S: Randy Moffitt (2) | Third | 6½ out |
| Friday, June 8 |
| » Lost to Pirates (28-23), 3-2 | Three Rivers Stadium (0-1) | 27-31 | |
| » W: Enrique Romo (3-2) L: John Curtis (1-3) S: Grant Jackson (7) | Fourth | 7½ out |
| Saturday, June 9 |
| » Defeated Pirates (28-24), 6-2 | Three Rivers Stadium (1-1) | 28-31 | |
| » W: Vida Blue (7-6) L: Bruce Kison (3-2) | Third | 6½ out |
| Sunday, June 10 |
| » Defeated Pirates (28-25), 7-4 | Three Rivers Stadium (2-1) | 29-31 | Won 2 |
| » W: Gary Lavelle (4-2) L: Enrique Romo (3-3) | Third | 6½ out |
| Tuesday, June 12 |
| » Defeated Cubs (26-29), 7-2 | Candlestick Park (15-13) | 30-31 | Won 3 |
| » W: Bob Knepper (6-2) L: Ken Holtzman (4-5) | Third | 5 out |
| Wednesday, June 13 |
| » Lost to Cubs (27-29), 3-2 | Candlestick Park (15-14) | 30-32 | |
| » W: Bruce Sutter (2-2) L: Randy Moffitt (1-5) | Third | 6 out |
| Thursday, June 14 |
| » Lost to Cubs (28-29), 8-6 | Candlestick Park (15-15) | 30-33 | Lost 2 |
| » W: Dick Tidrow (4-2) L: Gary Lavelle (4-3) S: Bruce Sutter (13) | Third | 6½ out |
| Friday, June 15 |
| » Defeated Cardinals (32-25), 9-6 | Candlestick Park (16-15) | 31-33 | |
| » W: Gary Lavelle (5-3) L: Darold Knowles (2-3) | Third | 6½ out |
| Saturday, June 16 |
| » Defeated Cardinals (32-26), 6-1 | Candlestick Park (17-15) | 32-33 | Won 2 |
| » W: John Curtis (2-3) L: Silvio Martinez (4-2) | Third | 5½ out |
| Sunday, June 17 |
| » Defeated Cardinals (32-27), 7-4 | Candlestick Park (18-15) | 33-33 | Won 3 |
| » W: Randy Moffitt (2-5) L: Buddy Schultz (4-3) S: Gary Lavelle (8) | Third | 4½ out |
| Tuesday, June 19 |
| » Lost to Pirates (32-28), 9-4 | Candlestick Park (18-16) | 33-34 | |
| » W: John Candelaria (5-6) L: John Montefusco (1-3) S: Enrique Romo (1) | Third | 6 out |
| Wednesday, June 20 |
| » Lost to Pirates (33-28), 8-5 | Candlestick Park (18-17) | 33-35 | Lost 2 |
| » W: Grant Jackson (4-0) L: Gary Lavelle (5-4) S: Kent Tekulve (9) | Third | 7 out |
| Friday, June 22 |
| » Defeated Reds (36-33), 3-2 | Riverfront Stadium (4-1) | 34-35 | |
| » W: Philip Nastu (3-4) L: Paul Moskau (4-3) S: Tom Griffin (2) | Third | 7 out |
| Saturday, June 23 |
| » Defeated Reds (36-34), 5-2 | Riverfront Stadium (5-1) | 35-35 | Won 2 |
| » W: John Curtis (3-3) L: Fred Norman (3-7) S: Gary Lavelle (9) | Third | 7 out |
| Sunday, June 24 |
| » Lost to Reds (37-34), 8-7 | Riverfront Stadium (5-2) | 35-36 | |
| » W: Doug Bair (4-2) L: Dave Roberts (0-2) | Third | 8 out |
| Monday, June 25 |
| » Lost to Braves (28-44), 6-1 | Candlestick Park (18-18) | 35-37 | Lost 2 |
| » W: Eddie Solomon (4-3) L: John Montefusco (1-4) S: Craig Skok (2) | Third | 8½ out |
| Tuesday, June 26 |
| » Defeated Braves (28-45), 6-5 | Candlestick Park (19-18) | 36-37 | |
| » W: Gary Lavelle (6-4) L: Gene Garber (3-10) | Third | 8½ out |
| Wednesday, June 27 |
| » Defeated Astros (46-31), 6-3 | Candlestick Park (20-18) | 37-37 | Won 2 |
| » W: Greg Minton (1-0) L: Tom Dixon (1-2) S: Dave Roberts (3) | Third | 7½ out |
| Thursday, June 28 |
| » Lost to Astros (47-31), 6-5 | Candlestick Park (20-19) | 37-38 | |
| » W: Rick Williams (3-3) L: John Curtis (3-4) S: Randy Niemann (1) | Third | 8½ out |
| » Major-league debuts: Joe Strain (Giants) |
| Friday, June 29 |
| » Defeated Reds (40-37), 6-4 | Candlestick Park (21-19) | 38-38 | |
| » W: Pedro Borbon (3-2) L: Manny Sarmiento (0-4) S: Gary Lavelle (10) | Third | 8½ out |
| Saturday, June 30 |
| » Lost to Reds (41-37), 2-0 | Candlestick Park (21-20) | 38-39 | |
| » W: Tom Seaver (6-5) L: Ed Whitson (2-4) | Third | 9½ out |
| Sunday, July 1 |
| » Defeated Reds (41-38), 2-1 | Candlestick Park (22-20) | 39-39 | |
| » W: John Curtis (4-4) L: Mike LaCoss (8-3) S: Pedro Borbon (3) | Third | 9 out |
| » Defeated Reds (41-39), 7-3 | Candlestick Park (23-20) | 40-39 | Won 2 |
| » W: Gary Lavelle (7-4) L: Mario Soto (0-1) | Third | 9 out |
| Tuesday, July 3 |
| » Lost to Braves (33-47), 5-2 | Atlanta-Fulton County Stadium (3-2) | 40-40 | |
| » W: Tony Brizzolara (3-3) L: Ed Halicki (5-4) S: Gene Garber (16) | Third | 10 out |
| Wednesday, July 4 |
| » Lost to Braves (34-47), 7-6 | Atlanta-Fulton County Stadium (3-3) | 40-41 | Lost 2 |
| » W: Joey McLaughlin (2-1) L: Gary Lavelle (7-5) S: Gene Garber (17) | Third | 11 out |
| Thursday, July 5 |
| » Lost to Braves (35-47), 5-4 | Atlanta-Fulton County Stadium (3-4) | 40-42 | Lost 3 |
| » W: Phil Niekro (11-10) L: Greg Minton (1-1) | Third | 11 out |
| Friday, July 6 |
| » Lost to Phillies (43-39), 6-1 | Veteran's Stadium (1-2) | 40-43 | Lost 4 |
| » W: Nino Espinosa (8-7) L: John Curtis (4-5) | Third | 12 out |
| Saturday, July 7 |
| » Defeated Phillies (43-40), 8-6 | Veteran's Stadium (2-2) | 41-43 | |
| » W: Pedro Borbon (4-2) L: Ron Reed (6-4) | Third | 10½ out |
| Sunday, July 8 |
| » Lost to Phillies (44-40), 5-3 | Veteran's Stadium (2-3) | 41-44 | |
| » W: Steve Carlton (10-8) L: Bob Knepper (6-3) | Third | 10½ out |
| Monday, July 9 |
| » Lost to Phillies (45-40), 4-2 | Veteran's Stadium (2-4) | 41-45 | Lost 2 |
| » W: Dickie Noles (1-1) L: Vida Blue (7-7) S: Warren Brusstar (1) | Third | 11 out |
| Tuesday, July 10 |
| » Defeated Expos (48-31), 11-7 | Stade Olympique (1-3) | 42-45 | |
| » W: Tom Griffin (4-4) L: Woodie Fryman (2-4) | Third | 10 out |
| Wednesday, July 11 |
| » Defeated Expos (48-32), 1-0 | Stade Olympique (2-3) | 43-45 | Won 2 |
| » W: John Curtis (5-5) L: Dan Schatzeder (4-2) | Third | 9 out |
| Thursday, July 12 |
| » Defeated Expos (48-33), 5-3 | Stade Olympique (3-3) | 44-45 | Won 3 |
| » W: John Montefusco (2-4) L: Steve Rogers (9-6) S: Gary Lavelle (11) | Third | 8 out |
| Friday, July 13 |
| » Lost to Mets (36-48), 7-6 | Shea Stadium (0-3) | 44-46 | |
| » W: Kevin Kobel (4-4) L: Bob Knepper (6-4) S: Dale Murray (3) | Third | 8½ out |
| » Lost to Mets (37-48), 5-2 | Shea Stadium (0-4) | 44-47 | Lost 2 |
| » W: Andy Hassler (4-4) L: Ed Halicki (5-5) S: Dale Murray (4) | Third | 8½ out |
| Saturday, July 14 |
| » Lost to Mets (38-48), 3-2 | Shea Stadium (0-5) | 44-48 | Lost 3 |
| » W: Tom Hausman (1-4) L: Vida Blue (7-8) | Third | 9½ out |
| Sunday, July 15 |
| » Defeated Mets (38-49), 4-0 | Shea Stadium (1-5) | 45-48 | |
| » W: Ed Whitson (3-4) L: Craig Swan (8-8) S: Pedro Borbon (4) | Third | 8½ out |
| Thursday, July 19 |
| » Defeated Phillies (50-42), 1-0 | Candlestick Park (24-20) | 46-48 | Won 2 |
| » W: John Curtis (6-5) L: Dickie Noles (2-2) | Third | 7 out |
| Friday, July 20 |
| » Lost to Phillies (51-42), 6-4 | Candlestick Park (24-21) | 46-49 | |
| » W: Randy Lerch (6-8) L: Tom Griffin (4-5) S: Ron Reed (3) | Third | 7 out |
| Saturday, July 21 |
| » Defeated Phillies (51-43), 4-1 | Candlestick Park (25-21) | 47-49 | |
| » W: Bob Knepper (7-4) L: Steve Carlton (11-9) | Third | 6 out |
| Sunday, July 22 |
| » Defeated Expos (51-38), 8-6 | Candlestick Park (26-21) | 48-49 | Won 2 |
| » W: Vida Blue (8-8) L: Ross Grimsley (8-6) S: Pedro Borbon (5) | Third | 6½ out |
| » Lost to Expos (52-38), 15-5 | Candlestick Park (26-22) | 48-50 | |
| » W: Rudy May (4-0) L: Ed Whitson (3-5) | Third | 6½ out |
| Monday, July 23 |
| » Lost to Expos (53-38), 8-3 | Candlestick Park (26-23) | 48-51 | Lost 2 |
| » W: Dan Schatzeder (5-3) L: John Curtis (6-6) | Third | 7½ out |
| Tuesday, July 24 |
| » Lost to Mets (40-53), 6-5 | Candlestick Park (26-24) | 48-52 | Lost 3 |
| » W: Wayne Twitchell (4-2) L: Pedro Borbon (4-3) S: Tom Hausman (2) | Third | 8½ out |
| Wednesday, July 25 |
| » Lost to Mets (41-53), 3-0 | Candlestick Park (26-25) | 48-53 | Lost 4 |
| » W: Craig Swan (9-9) L: Bob Knepper (7-5) | Third | 9½ out |
| Thursday, July 26 |
| » Defeated Padres (47-57), 6-2 | San Diego/Jack Murphy Stadium (2-2) | 49-53 | |
| » W: Ed Whitson (4-5) L: John D'Acquisto (6-8) S: Gary Lavelle (12) | Third | 8½ out |
| Friday, July 27 |
| » Defeated Padres (47-58), 4-3 | San Diego/Jack Murphy Stadium (3-2) | 50-53 | Won 2 |
| » W: Pedro Borbon (5-3) L: Mark Lee (1-2) | Third | 7½ out |
| Saturday, July 28 |
| » Lost to Padres (48-58), 4-3 | San Diego/Jack Murphy Stadium (3-3) | 50-54 | |
| » W: Rollie Fingers (9-7) L: Pedro Borbon (5-4) | Third | 8½ out |
| Sunday, July 29 |
| » Defeated Padres (48-59), 4-2 | San Diego/Jack Murphy Stadium (4-3) | 51-54 | |
| » W: John Montefusco (3-4) L: Bob Shirley (4-11) S: Gary Lavelle (13) | Third | 8½ out |
| Monday, July 30 |
| » Defeated Astros (60-47), 8-0 | Astrodome (4-0) | 52-54 | Won 2 |
| » W: Bob Knepper (8-5) L: Joaquin Andujar (11-7) | Third | 7½ out |
| Tuesday, July 31 |
| » Lost to Astros (61-47), 6-4 | Astrodome (4-1) | 52-55 | |
| » W: Joe Niekro (15-6) L: Ed Whitson (4-6) S: Bert Roberge (3) | Third | 8½ out |
| Wednesday, August 1 |
| » Lost to Astros (62-47), 5-4 | Astrodome (4-2) | 52-56 | Lost 2 |
| » W: Ken Forsch (8-6) L: Vida Blue (8-9) S: Bert Roberge (4) | Third | 9½ out |
| Friday, August 3 |
| » Lost to Dodgers (46-62), 11-3 | Dodger Stadium (0-4) | 52-57 | Lost 3 |
| » W: Burt Hooton (10-7) L: John Curtis (6-7) | Third | 10½ out |
| » Major-league debuts: Mickey Hatcher (Dodgers) |
| Saturday, August 4 |
| » Lost to Dodgers (47-62), 4-3 | Dodger Stadium (0-5) | 52-58 | Lost 4 |
| » W: Dave Patterson (2-0) L: Gary Lavelle (7-6) | Third | 12 out |
| Sunday, August 5 |
| » Lost to Dodgers (48-62), 8-1 | Dodger Stadium (0-6) | 52-59 | Lost 5 |
| » W: Don Sutton (9-12) L: Bob Knepper (8-6) | Third | 13 out |
| Monday, August 6 |
| » Defeated Dodgers (48-63), 7-1 | Dodger Stadium (1-6) | 53-59 | |
| » W: Ed Whitson (5-6) L: Charlie Hough (2-4) | Third | 12½ out |
| Tuesday, August 7 |
| » Defeated Padres (50-64), 3-2 | Candlestick Park (27-25) | 54-59 | Won 2 |
| » W: Vida Blue (9-9) L: Gaylord Perry (10-8) S: Gary Lavelle (14) | Third | 11½ out |
| Wednesday, August 8 |
| » Defeated Padres (50-65), 10-7 | Candlestick Park (28-25) | 55-59 | Won 3 |
| » W: John Curtis (7-7) L: Bob Shirley (5-12) S: Gary Lavelle (15) | Third | 11½ out |
| Thursday, August 9 |
| » Lost to Padres (51-65), 4-0 | Candlestick Park (28-26) | 55-60 | |
| » W: John D'Acquisto (8-9) L: Greg Minton (1-2) | Third | 11½ out |
| Friday, August 10 |
| » Lost to Dodgers (51-64), 9-0 | Candlestick Park (28-27) | 55-61 | Lost 2 |
| » W: Don Sutton (10-12) L: Bob Knepper (8-7) | Third | 12½ out |
| Saturday, August 11 |
| » Lost to Dodgers (52-64), 7-4 | Candlestick Park (28-28) | 55-62 | Lost 3 |
| » W: Charlie Hough (3-4) L: Ed Whitson (5-7) S: Dave Patterson (5) | Third | 13 out |
| Sunday, August 12 |
| » Defeated Dodgers (52-65), 4-1 | Candlestick Park (29-28) | 56-62 | |
| » W: Vida Blue (10-9) L: Jerry Reuss (3-10) | Third | 12 out |
| Tuesday, August 14 |
| » Defeated Cubs (61-54), 8-2 | Wrigley Field (2-2) | 57-62 | Won 2 |
| » W: John Curtis (8-7) L: Mike Krukow (9-8) | Third | 12½ out |
| Wednesday, August 15 |
| » Lost to Cubs (62-54), 6-5 | Wrigley Field (2-3) | 57-63 | |
| » W: Rick Reuschel (13-7) L: Pedro Borbon (5-5) S: Bruce Sutter (29) | Third | 12½ out |
| Thursday, August 16 |
| » Lost to Cubs (63-54), 14-4 | Wrigley Field (2-4) | 57-64 | Lost 2 |
| » W: Lynn McGlothen (10-8) L: Bob Knepper (8-8) | Third | 13 out |
| Friday, August 17 |
| » Lost to Cardinals (61-58), 3-0 | Busch Stadium II (1-3) | 57-65 | Lost 3 |
| » W: John Fulgham (5-4) L: Ed Whitson (5-8) | Third | 13 out |
| Saturday, August 18 |
| » Lost to Cardinals (62-58), 5-4 | Busch Stadium II (1-4) | 57-66 | Lost 4 |
| » W: Roy Thomas (2-2) L: Vida Blue (10-10) | Fourth | 13 out |
| Sunday, August 19 |
| » Lost to Cardinals (63-58), 4-0 | Busch Stadium II (1-5) | 57-67 | Lost 5 |
| » W: John Denny (7-10) L: John Curtis (8-8) S: Mark Littell (8) | Fourth | 13 out |
| Monday, August 20 |
| » Lost to Pirates (72-51), 6-5 | Three Rivers Stadium (2-2) | 57-68 | Lost 6 |
| » W: Enrique Romo (10-3) L: Gary Lavelle (7-7) S: Kent Tekulve (23) | Fourth | 14 out |
| Tuesday, August 21 |
| » Defeated Pirates (72-52), 6-1 | Three Rivers Stadium (3-2) | 58-68 | |
| » W: Bob Knepper (9-8) L: Bruce Kison (8-7) | Fourth | 13 out |
| Wednesday, August 22 |
| » Lost to Pirates (73-52), 8-6 | Three Rivers Stadium (3-3) | 58-69 | |
| » W: Kent Tekulve (8-6) L: Gary Lavelle (7-8) | Fourth | 14 out |
| Friday, August 24 |
| » Lost to Cubs (68-56), 4-1 | Candlestick Park (29-29) | 58-70 | Lost 2 |
| » W: Rick Reuschel (15-7) L: Vida Blue (10-11) | Fourth | 14 out |
| Saturday, August 25 |
| » Defeated Cubs (68-57), 5-2 | Candlestick Park (30-29) | 59-70 | |
| » W: John Curtis (9-8) L: Lynn McGlothen (11-9) S: Greg Minton (1) | Fourth | 14 out |
| Sunday, August 26 |
| » Lost to Cubs (69-57), 4-1 | Candlestick Park (30-30) | 59-71 | |
| » W: Dennis Lamp (9-7) L: John Montefusco (3-5) S: Bruce Sutter (33) | Fourth | 15 out |
| Tuesday, August 28 |
| » Lost to Cardinals (68-60), 2-1 | Candlestick Park (30-31) | 59-72 | Lost 2 |
| » W: Bob Forsch (7-10) L: Bob Knepper (9-9) S: Mark Littell (9) | Fourth | 16 out |
| Wednesday, August 29 |
| » Lost to Cardinals (69-60), 5-1 | Candlestick Park (30-32) | 59-73 | Lost 3 |
| » W: John Fulgham (7-4) L: Vida Blue (10-12) | Fourth | 17 out |
| Thursday, August 30 |
| » Defeated Cardinals (69-61), 3-2 | Candlestick Park (31-32) | 60-73 | |
| » W: Ed Whitson (6-8) L: Pete Vuckovich (12-9) | Fourth | 16½ out |
| Friday, August 31 |
| » Lost to Pirates (78-54), 6-4 | Candlestick Park (31-33) | 60-74 | |
| » W: Don Robinson (7-6) L: John Curtis (9-9) S: Grant Jackson (12) | Fourth | 16½ out |
| Saturday, September 1 |
| » Lost to Pirates (79-54), 5-3 | Candlestick Park (31-34) | 60-75 | Lost 2 |
| » W: Bruce Kison (10-7) L: John Montefusco (3-6) S: Grant Jackson (13) | Fourth | 17½ out |
| » Lost to Pirates (80-54), 7-2 | Candlestick Park (31-35) | 60-76 | Lost 3 |
| » W: Jim Bibby (10-3) L: Bob Knepper (9-10) | Fourth | 17½ out |
| Sunday, September 2 |
| » Lost to Pirates (81-54), 5-3 | Candlestick Park (31-36) | 60-77 | Lost 4 |
| » W: John Candelaria (13-8) L: Vida Blue (10-13) | Fourth | 17½ out |
| Monday, September 3 |
| » Lost to Padres (58-80), 3-0 | San Diego/Jack Murphy Stadium (4-4) | 60-78 | Lost 5 |
| » W: Gaylord Perry (12-11) L: Ed Whitson (6-9) S: Eric Rasmussen (3) | Fourth | 18 out |
| » Major-league debuts: Tim Flannery (Padres) |
| Tuesday, September 4 |
| » Defeated Padres (58-81), 3-1 | San Diego/Jack Murphy Stadium (5-4) | 61-78 | |
| » W: John Curtis (10-9) L: Bob Shirley (6-14) S: Gary Lavelle (16) | Fourth | 17½ out |
| Wednesday, September 5 |
| » Lost to Reds (79-61), 6-5 | Riverfront Stadium (5-3) | 61-79 | |
| » W: Fred Norman (11-10) L: John Montefusco (3-7) S: Tom Hume (13) | Fourth | 18½ out |
| Thursday, September 6 |
| » Lost to Reds (80-61), 12-3 | Riverfront Stadium (5-4) | 61-80 | Lost 2 |
| » Manager: Dave Bristol |
| » W: Tom Seaver (14-6) L: Bob Knepper (9-11) | Fourth | 19½ out |
| Friday, September 7 |
| » Defeated Astros (80-61), 9-2 | Astrodome (5-2) | 62-80 | |
| » W: Vida Blue (11-13) L: Joaquin Andujar (12-11) | Fourth | 18½ out |
| Saturday, September 8 |
| » Defeated Astros (80-62), 2-1 | Astrodome (6-2) | 63-80 | Won 2 |
| » W: Greg Minton (2-2) L: Joe Sambito (7-5) S: Gary Lavelle (17) | Fourth | 18 out |
| Sunday, September 9 |
| » Lost to Astros (81-62), 4-1 | Astrodome (6-3) | 63-81 | |
| » W: Ken Forsch (10-6) L: Greg Minton (2-3) S: Joe Sambito (19) | Fourth | 18½ out |
| Tuesday, September 11 |
| » Lost to Braves (56-87), 2-1 | Candlestick Park (31-37) | 63-82 | Lost 2 |
| » W: Larry McWilliams (2-2) L: John Montefusco (3-8) S: Joey McLaughlin (5) | Fourth | 19 out |
| Wednesday, September 12 |
| » Defeated Braves (56-88), 4-3 | Candlestick Park (32-37) | 64-82 | |
| » W: Vida Blue (12-13) L: Eddie Solomon (6-12) S: Gary Lavelle (18) | Fourth | 19 out |
| Thursday, September 13 |
| » Lost to Braves (57-88), 4-1 | Candlestick Park (32-38) | 64-83 | |
| » W: Phil Niekro (18-19) L: Ed Whitson (6-10) | Fourth | 19½ out |
| Friday, September 14 |
| » Lost to Astros (82-64), 7-0 | Candlestick Park (32-39) | 64-84 | Lost 2 |
| » W: Vern Ruhle (2-3) L: Ed Halicki (5-6) | Fourth | 19½ out |
| Saturday, September 15 |
| » Defeated Astros (82-65), 5-3 | Candlestick Park (33-39) | 65-84 | |
| » W: Pedro Borbon (6-5) L: Joaquin Andujar (12-12) S: Greg Minton (2) | Fourth | 19½ out |
| Sunday, September 16 |
| » Defeated Astros (82-66), 2-1 | Candlestick Park (34-39) | 66-84 | Won 2 |
| » W: Greg Minton (3-3) L: J.R. Richard (16-13) | Fourth | 19½ out |
| Monday, September 17 |
| » Defeated Reds (85-65), 7-4 | Candlestick Park (35-39) | 67-84 | Won 3 |
| » W: Vida Blue (13-13) L: Mike LaCoss (14-7) S: Gary Lavelle (19) | Fourth | 18½ out |
| » Major-league debuts: Charlie Leibrandt (Reds) |
| Tuesday, September 18 |
| » Defeated Reds (85-66), 3-1 | Candlestick Park (36-39) | 68-84 | Won 4 |
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