| Wednesday, April 4 |
| » Major-league debuts: Mark Clear (Angels) |
| Friday, April 6 |
| » Defeated Phillies (0-1), 8-1 | Busch Stadium II (1-0) | 1-0 | |
| » W: John Denny (1-0) L: Steve Carlton (0-1) | First | -- |
| Saturday, April 7 |
| » Defeated Phillies (0-2), 3-2 | Busch Stadium II (2-0) | 2-0 | Won 2 |
| » W: Pete Vuckovich (1-0) L: Ron Reed (0-1) | First | -- |
| Sunday, April 8 |
| » Tied Phillies, 2-2 | Busch Stadium II (2-0) | 2-0 | |
| » Starters: Nino Espinosa vs Bob Forsch | First | -- |
| Tuesday, April 10 |
| » Defeated Cubs (0-3), 7-0 | Busch Stadium II (3-0) | 3-0 | Won 3 |
| » W: Bob Sykes (1-0) L: Lynn McGlothen (0-1) | First | -- |
| Thursday, April 12 |
| » Lost to Pirates (2-4), 3-1 | Three Rivers Stadium (0-1) | 3-1 | |
| » W: Don Robinson (1-0) L: John Denny (1-1) | Second | ½ out |
| Friday, April 13 |
| » Lost to Pirates (3-4), 7-6 | Three Rivers Stadium (0-2) | 3-2 | Lost 2 |
| » W: Jim Bibby (1-0) L: Buddy Schultz (0-1) S: Grant Jackson (1) | Second | 1 out |
| Saturday, April 14 |
| » Lost to Pirates (4-4), 7-4 | Three Rivers Stadium (0-3) | 3-3 | Lost 3 |
| » W: Ed Whitson (1-0) L: Bob Forsch (0-1) S: Grant Jackson (2) | Third | 2 out |
| Sunday, April 15 |
| » Defeated Pirates (4-5), 9-4 | Three Rivers Stadium (1-3) | 4-3 | |
| » W: Mark Littell (1-0) L: Kent Tekulve (0-2) | Second | 1 out |
| Tuesday, April 17 |
| » Lost to Cubs (2-5), 5-3 | Wrigley Field (0-1) | 4-4 | |
| » W: Ken Holtzman (1-1) L: John Denny (1-2) S: Bruce Sutter (1) | Third | 2½ out |
| Wednesday, April 18 |
| » Defeated Cubs (2-6), 3-2 | Wrigley Field (1-1) | 5-4 | |
| » W: Tom Bruno (1-0) L: Donnie Moore (0-1) S: Darold Knowles (1) | Third | 2½ out |
| Thursday, April 19 |
| » Lost to Cubs (3-6), 3-2 | Wrigley Field (1-2) | 5-5 | |
| » W: Dennis Lamp (1-0) L: Bob Forsch (0-2) S: Bruce Sutter (2) | Third | 3 out |
| Friday, April 20 |
| » Lost to Reds (8-6), 10-3 | Busch Stadium II (3-1) | 5-6 | Lost 2 |
| » W: Fred Norman (1-2) L: Bob Sykes (1-1) | Third | 3 out |
| Saturday, April 21 |
| » Lost to Reds (9-6), 4-1 | Busch Stadium II (3-2) | 5-7 | Lost 3 |
| » W: Mike LaCoss (1-0) L: Silvio Martinez (0-1) S: Doug Bair (3) | Fourth | 3½ out |
| Sunday, April 22 |
| » Defeated Reds (9-7), 4-3 | Busch Stadium II (4-2) | 6-7 | |
| » W: Buddy Schultz (1-1) L: Tom Hume (2-2) | Fourth | 2½ out |
| Monday, April 23 |
| » Defeated Braves (5-11), 3-2 | Atlanta-Fulton County Stadium (1-0) | 7-7 | Won 2 |
| » W: Mark Littell (2-0) L: Phil Niekro (1-4) | Fourth | 2½ out |
| Tuesday, April 24 |
| » Defeated Braves (5-12), 6-5 | Atlanta-Fulton County Stadium (2-0) | 8-7 | Won 3 |
| » W: Mark Littell (3-0) L: Gene Garber (1-2) S: Buddy Schultz (1) | Third | 2½ out |
| Friday, April 27 |
| » Lost to Reds (10-9), 4-3 | Riverfront Stadium (0-1) | 8-8 | |
| » W: Frank Pastore (1-2) L: Mark Littell (3-1) | Third | 4 out |
| Former Cardinal Jim Mooney dies in Johnson City, TN at the age of 73. |
| Saturday, April 28 |
| » Defeated Reds (10-10), 12-1 | Riverfront Stadium (1-1) | 9-8 | |
| » W: Pete Vuckovich (2-0) L: Tom Hume (2-3) | Second | 3 out |
| Sunday, April 29 |
| » Lost to Reds (11-10), 5-1 | Riverfront Stadium (1-2) | 9-9 | |
| » W: Paul Moskau (1-0) L: Bob Sykes (1-2) | Second | 4 out |
| Monday, April 30 |
| » Lost to Astros (15-6), 6-5 | Busch Stadium II (4-3) | 9-10 | Lost 2 |
| » W: Joe Sambito (2-0) L: Tom Bruno (1-1) S: Joaquin Andujar (2) | Second | 5 out |
| Tuesday, May 1 |
| » Defeated Astros (15-7), 7-6 | Busch Stadium II (5-3) | 10-10 | |
| » W: Darold Knowles (1-0) L: Joe Sambito (2-1) | Fourth | 5 out |
| Wednesday, May 2 |
| » Defeated Astros (15-8), 5-2 | Busch Stadium II (6-3) | 11-10 | Won 2 |
| » W: John Denny (2-2) L: Ken Forsch (3-1) | Third | 4½ out |
| Thursday, May 3 |
| » Lost to Astros (16-8), 4-1 | Busch Stadium II (6-4) | 11-11 | |
| » W: Joe Niekro (2-2) L: Pete Vuckovich (2-1) S: Joaquin Andujar (3) | Third | 4½ out |
| Friday, May 4 |
| » Defeated Pirates (8-13), 4-3 | Busch Stadium II (7-4) | 12-11 | |
| » W: Bob Sykes (2-2) L: Don Robinson (2-2) S: Buddy Schultz (2) | Third | 4½ out |
| Saturday, May 5 |
| » Lost to Pirates (9-13), 6-5 | Busch Stadium II (7-5) | 12-12 | |
| » W: Grant Jackson (2-0) L: Pete Vuckovich (2-2) S: Ed Whitson (1) | Third | 4½ out |
| Sunday, May 6 |
| » Defeated Pirates (9-14), 4-2 | Busch Stadium II (8-5) | 13-12 | |
| » W: Silvio Martinez (1-1) L: Bruce Kison (1-1) S: Darold Knowles (2) | Third | 4½ out |
| Tuesday, May 8 |
| » Defeated Astros (17-12), 4-1 | Astrodome (1-0) | 14-12 | Won 2 |
| » W: Pete Vuckovich (3-2) L: Ken Forsch (3-2) S: Darold Knowles (3) | Third | 5 out |
| Wednesday, May 9 |
| » Lost to Astros (18-12), 5-4 | Astrodome (1-1) | 14-13 | |
| » W: Bo McLaughlin (1-0) L: Tom Bruno (1-2) | Third | 6 out |
| Thursday, May 10 |
| » Defeated Astros (18-13), 3-1 | Astrodome (2-1) | 15-13 | |
| » W: Bob Sykes (3-2) L: J.R. Richard (4-2) S: Mark Littell (1) | Third | 6 out |
| Friday, May 11 |
| » Lost to Braves (10-19), 3-0 | Busch Stadium II (8-6) | 15-14 | |
| » W: Adrian Devine (1-0) L: Bob Forsch (0-3) S: Gene Garber (5) | Fourth | 6 out |
| Saturday, May 12 |
| » Defeated Braves (10-20), 7-6 | Busch Stadium II (9-6) | 16-14 | |
| » W: Buddy Schultz (2-1) L: Gene Garber (1-6) | Fourth | 5 out |
| Former Cardinal Clyde Kluttz dies in Salisbury, NC at the age of 62. |
| Sunday, May 13 |
| » Defeated Braves (10-21), 7-3 | Busch Stadium II (10-6) | 17-14 | Won 2 |
| » W: Pete Vuckovich (4-2) L: Phil Niekro (3-6) | Third | 5 out |
| Tuesday, May 15 |
| » Defeated Expos (19-12), 1-0 | Busch Stadium II (11-6) | 18-14 | Won 3 |
| » W: John Denny (3-2) L: Steve Rogers (3-2) | Third | 4 out |
| Wednesday, May 16 |
| » Defeated Expos (19-13), 2-0 | Busch Stadium II (12-6) | 19-14 | Won 4 |
| » W: Bob Forsch (1-3) L: Bill Lee (4-2) S: Mark Littell (2) | Third | 4 out |
| Thursday, May 17 |
| » Lost to Expos (20-13), 3-2 | Busch Stadium II (12-7) | 19-15 | |
| » W: Elias Sosa (3-1) L: Buddy Schultz (2-2) | Third | 5 out |
| Friday, May 18 |
| Former Cardinal Ray Blades dies in Lincoln, IL at the age of 83. |
| Saturday, May 19 |
| » Defeated Mets (11-23), 9-4 | Shea Stadium (1-0) | 20-15 | |
| » W: Darold Knowles (2-0) L: Dwight Bernard (0-1) | Third | 3½ out |
| Sunday, May 20 |
| » Lost to Mets (12-23), 8-7 | Shea Stadium (1-1) | 20-16 | |
| » W: Neil Allen (1-5) L: Darold Knowles (2-1) | Third | 3½ out |
| Monday, May 21 |
| » Lost to Phillies (25-13), 5-3 | Veteran's Stadium (0-1) | 20-17 | Lost 2 |
| » W: Steve Carlton (5-5) L: John Denny (3-3) | Third | 4½ out |
| Tuesday, May 22 |
| » Lost to Phillies (26-13), 3-1 | Veteran's Stadium (0-2) | 20-18 | Lost 3 |
| » W: Tug McGraw (2-0) L: Bob Forsch (1-4) | Third | 5½ out |
| Wednesday, May 23 |
| » Defeated Phillies (26-14), 3-1 | Veteran's Stadium (1-2) | 21-18 | |
| » W: Silvio Martinez (2-1) L: Dick Ruthven (6-2) S: Mark Littell (3) | Third | 4½ out |
| Sunday, May 27 |
| » Lost to Expos (26-14), 8-3 | Stade Olympique (0-1) | 21-19 | |
| » W: Scott Sanderson (3-3) L: John Denny (3-4) | Third | 4 out |
| » Defeated Expos (26-15), 11-3 | Stade Olympique (1-1) | 22-19 | |
| » W: Bob Forsch (2-4) L: Ross Grimsley (4-3) | Third | 4 out |
| Tuesday, May 29 |
| » Lost to Mets (16-26), 6-2 | Busch Stadium II (12-8) | 22-20 | |
| » W: Pat Zachry (4-0) L: Pete Vuckovich (4-3) S: Skip Lockwood (8) | Third | 5 out |
| Wednesday, May 30 |
| » Defeated Mets (16-27), 7-3 | Busch Stadium II (13-8) | 23-20 | |
| » W: Silvio Martinez (3-1) L: Craig Swan (4-4) S: Darold Knowles (4) | Third | 5 out |
| Thursday, May 31 |
| » Defeated Mets (16-28), 9-6 | Busch Stadium II (14-8) | 24-20 | Won 2 |
| » W: Bob Sykes (4-2) L: Mike Scott (1-1) S: Darold Knowles (5) | Third | 5 out |
| Friday, June 1 |
| » Defeated Dodgers (26-27), 8-7 | Busch Stadium II (15-8) | 25-20 | Won 3 |
| » W: Buddy Schultz (3-2) L: Bob Welch (4-2) | Third | 4 out |
| Saturday, June 2 |
| » Defeated Dodgers (26-28), 12-5 | Busch Stadium II (16-8) | 26-20 | Won 4 |
| » W: Bob Forsch (3-4) L: Doug Rau (1-5) | Second | 3 out |
| Sunday, June 3 |
| » Defeated Dodgers (26-29), 6-4 | Busch Stadium II (17-8) | 27-20 | Won 5 |
| » W: Pete Vuckovich (5-3) L: Burt Hooton (4-3) | Second | 2 out |
| Tuesday, June 5 |
| » Defeated Giants (26-29), 5-4 | Busch Stadium II (18-8) | 28-20 | Won 6 |
| » W: Mark Littell (4-1) L: Randy Moffitt (1-3) | Second | 1½ out |
| Wednesday, June 6 |
| » Defeated Giants (26-30), 6-5 | Busch Stadium II (19-8) | 29-20 | Won 7 |
| » W: Buddy Schultz (4-2) L: Randy Moffitt (1-4) S: Mark Littell (4) | Second | 1½ out |
| Thursday, June 7 |
| » Lost to Giants (27-30), 12-10 | Busch Stadium II (19-9) | 29-21 | |
| » W: Tom Griffin (3-4) L: Mark Littell (4-2) S: Randy Moffitt (2) | Second | 2 out |
| Friday, June 8 |
| » Lost to Padres (27-33), 8-7 | Busch Stadium II (19-10) | 29-22 | Lost 2 |
| » W: Rollie Fingers (6-3) L: Darold Knowles (2-2) S: John D'Acquisto (2) | Second | 2 out |
| Saturday, June 9 |
| » Defeated Padres (27-34), 7-4 | Busch Stadium II (20-10) | 30-22 | |
| » W: Pete Vuckovich (6-3) L: Eric Rasmussen (3-6) | Second | 1 out |
| » Major-league debuts: Tom Tellmann (Padres) |
| Sunday, June 10 |
| » Defeated Padres (27-35), 3-2 | Busch Stadium II (21-10) | 31-22 | Won 2 |
| » W: Silvio Martinez (4-1) L: Randy Jones (5-5) S: Buddy Schultz (3) | First | -- |
| Monday, June 11 |
| » Defeated Dodgers (28-34), 9-7 | Dodger Stadium (1-0) | 32-22 | Won 3 |
| » W: Tom Bruno (2-2) L: Lerrin LaGrow (1-4) | First | -- |
| Former Cardinal Freddie Martin dies in Chicago, IL at the age of 64. |
| Tuesday, June 12 |
| » Lost to Dodgers (29-34), 9-3 | Dodger Stadium (1-1) | 32-23 | |
| » W: Burt Hooton (6-3) L: John Denny (3-5) | Second | ½ out |
| Wednesday, June 13 |
| » Lost to Dodgers (30-34), 9-8 | Dodger Stadium (1-2) | 32-24 | Lost 2 |
| » W: Rick Sutcliffe (7-4) L: Bob Forsch (3-5) S: Terry Forster (1) | Second | 1½ out |
| Friday, June 15 |
| » Lost to Giants (31-33), 9-6 | Candlestick Park (0-1) | 32-25 | Lost 3 |
| » W: Gary Lavelle (5-3) L: Darold Knowles (2-3) | Second | 2 out |
| Saturday, June 16 |
| » Lost to Giants (32-33), 6-1 | Candlestick Park (0-2) | 32-26 | Lost 4 |
| » W: John Curtis (2-3) L: Silvio Martinez (4-2) | Second | 3 out |
| Sunday, June 17 |
| » Lost to Giants (33-33), 7-4 | Candlestick Park (0-3) | 32-27 | Lost 5 |
| » W: Randy Moffitt (2-5) L: Buddy Schultz (4-3) S: Gary Lavelle (8) | Second | 4 out |
| Monday, June 18 |
| » Lost to Padres (31-38), 3-2 | San Diego/Jack Murphy Stadium (0-1) | 32-28 | Lost 6 |
| » W: Randy Jones (6-5) L: Bob Forsch (3-6) S: Rollie Fingers (10) | Second | 4 out |
| Tuesday, June 19 |
| » Defeated Padres (31-39), 7-2 | San Diego/Jack Murphy Stadium (1-1) | 33-28 | |
| » W: John Fulgham (1-0) L: Eric Rasmussen (3-7) | Second | 4 out |
| » Major-league debuts: John Fulgham (Cardinals) |
| Wednesday, June 20 |
| » Lost to Padres (32-39), 3-1 | San Diego/Jack Murphy Stadium (1-2) | 33-29 | |
| » W: Gaylord Perry (7-5) L: Pete Vuckovich (6-4) | Third | 5 out |
| Friday, June 22 |
| » Defeated Mets (26-37), 4-2 | Busch Stadium II (22-10) | 34-29 | |
| » W: Silvio Martinez (5-2) L: Kevin Kobel (3-3) | Third | 5 out |
| Sunday, June 24 |
| » Lost to Mets (27-37), 6-2 | Busch Stadium II (22-11) | 34-30 | |
| » W: Andy Hassler (2-3) L: Bob Forsch (3-7) S: Dale Murray (2) | Second | 5½ out |
| Monday, June 25 |
| » Lost to Expos (41-25), 8-2 | Busch Stadium II (22-12) | 34-31 | Lost 2 |
| » W: Dan Schatzeder (3-1) L: John Fulgham (1-1) | Third | 6½ out |
| Tuesday, June 26 |
| » Lost to Expos (42-25), 5-3 | Busch Stadium II (22-13) | 34-32 | Lost 3 |
| » W: Ross Grimsley (8-4) L: John Denny (3-6) S: Woodie Fryman (4) | Fifth | 7½ out |
| Wednesday, June 27 |
| » Defeated Expos (42-26), 5-0 | Busch Stadium II (23-13) | 35-32 | |
| » W: Silvio Martinez (6-2) L: Steve Rogers (7-5) | Third | 6½ out |
| Friday, June 29 |
| » Lost to Phillies (38-35), 8-7 | Busch Stadium II (23-14) | 35-33 | |
| » W: Kevin Saucier (1-0) L: Bob Forsch (3-8) S: Tug McGraw (7) | Fourth | 6 out |
| » Defeated Phillies (38-36), 7-1 | Busch Stadium II (24-14) | 36-33 | |
| » W: Pete Vuckovich (7-4) L: Larry Christenson (2-6) | Fourth | 6 out |
| Saturday, June 30 |
| » Lost to Phillies (39-36), 6-4 | Busch Stadium II (24-15) | 36-34 | |
| » W: Ron Reed (6-3) L: George Frazier (0-1) S: Tug McGraw (8) | Fifth | 7 out |
| Sunday, July 1 |
| » Defeated Phillies (39-37), 13-7 | Busch Stadium II (25-15) | 37-34 | |
| » W: Mark Littell (5-2) L: Tug McGraw (3-1) | Third | 6 out |
| » Defeated Phillies (39-38), 2-1 | Busch Stadium II (26-15) | 38-34 | Won 2 |
| » W: Mark Littell (6-2) L: Randy Lerch (4-7) | Third | 6 out |
| Monday, July 2 |
| » Lost to Pirates (38-34), 5-4 | Busch Stadium II (26-16) | 38-35 | |
| » W: Enrique Romo (4-3) L: Darold Knowles (2-4) S: Grant Jackson (9) | Third | 7 out |
| Tuesday, July 3 |
| » Lost to Pirates (39-34), 4-1 | Busch Stadium II (26-17) | 38-36 | Lost 2 |
| » W: John Candelaria (7-6) L: Bob Forsch (3-9) S: Enrique Romo (2) | Fourth | 7 out |
| Wednesday, July 4 |
| » Lost to Pirates (40-34), 6-4 | Busch Stadium II (26-18) | 38-37 | Lost 3 |
| » W: Bert Blyleven (6-3) L: Pete Vuckovich (7-5) S: Grant Jackson (10) | Fifth | 8 out |
| Thursday, July 5 |
| » Defeated Pirates (40-35), 2-0 | Busch Stadium II (27-18) | 39-37 | |
| » W: John Fulgham (2-1) L: Jim Rooker (2-3) | Fourth | 7 out |
| Friday, July 6 |
| » Defeated Braves (35-48), 9-5 | Atlanta-Fulton County Stadium (3-0) | 40-37 | Won 2 |
| » W: John Denny (4-6) L: Eddie Solomon (4-4) | Second | 6½ out |
| » Defeated Braves (35-49), 5-4 | Atlanta-Fulton County Stadium (4-0) | 41-37 | Won 3 |
| » W: George Frazier (1-1) L: Craig Skok (1-3) | Second | 6½ out |
| Saturday, July 7 |
| » Lost to Braves (36-49), 10-2 | Atlanta-Fulton County Stadium (4-1) | 41-38 | |
| » W: Tony Brizzolara (4-3) L: Silvio Martinez (6-3) | Third | 7½ out |
| Sunday, July 8 |
| » Lost to Braves (37-49), 6-5 | Atlanta-Fulton County Stadium (4-2) | 41-39 | Lost 2 |
| » W: Gene Garber (5-10) L: Mark Littell (6-3) | Fifth | 7½ out |
| Monday, July 9 |
| » Defeated Reds (45-43), 6-3 | Riverfront Stadium (2-2) | 42-39 | |
| » W: Pete Vuckovich (8-5) L: Bill Bonham (3-3) S: Mark Littell (5) | Fourth | 7½ out |
| Tuesday, July 10 |
| » Lost to Reds (46-43), 4-2 | Riverfront Stadium (2-3) | 42-40 | |
| » W: Tom Seaver (8-5) L: John Fulgham (2-2) S: Doug Bair (13) | Fifth | 7½ out |
| Wednesday, July 11 |
| » Lost to Reds (47-43), 6-1 | Riverfront Stadium (2-4) | 42-41 | Lost 2 |
| » W: Mike LaCoss (9-3) L: John Denny (4-7) | Fifth | 7½ out |
| Friday, July 13 |
| » Defeated Astros (53-39), 1-0 | Astrodome (3-1) | 43-41 | |
| » W: Silvio Martinez (7-3) L: Ken Forsch (5-5) | Fifth | 6½ out |
| Saturday, July 14 |
| » Lost to Astros (54-39), 3-2 | Astrodome (3-2) | 43-42 | |
| » W: Joaquin Andujar (11-5) L: Pete Vuckovich (8-6) S: Joe Sambito (11) | Fifth | 6½ out |
| Sunday, July 15 |
| » Defeated Astros (54-40), 3-1 | Astrodome (4-2) | 44-42 | |
| » W: John Fulgham (3-2) L: J.R. Richard (7-10) | Fifth | 6½ out |
| Thursday, July 19 |
| » Lost to Reds (49-46), 16-4 | Busch Stadium II (27-19) | 44-43 | |
| » W: Fred Norman (6-8) L: Pete Vuckovich (8-7) | Fourth | 6½ out |
| Future Cardinal Rick Ankiel is born in Fort Pierce, FL. |
| Friday, July 20 |
| » Lost to Reds (50-46), 3-0 | Busch Stadium II (27-20) | 44-44 | Lost 2 |
| » W: Tom Seaver (10-5) L: John Denny (4-8) | Fourth | 6½ out |
| Saturday, July 21 |
| » Defeated Reds (50-47), 12-3 | Busch Stadium II (28-20) | 45-44 | |
| » W: Silvio Martinez (8-3) L: Mike LaCoss (9-4) | Fourth | 6½ out |
| Sunday, July 22 |
| » Lost to Astros (55-44), 7-6 | Busch Stadium II (28-21) | 45-45 | |
| » W: Joe Sambito (5-3) L: Will McEnaney (0-1) | Fifth | 7 out |
| Monday, July 23 |
| » Lost to Astros (56-44), 3-2 | Busch Stadium II (28-22) | 45-46 | Lost 2 |
| » W: Joe Niekro (14-5) L: John Fulgham (3-3) | Fifth | 8 out |
| Tuesday, July 24 |
| » Defeated Braves (41-59), 7-3 | Busch Stadium II (29-22) | 46-46 | |
| » W: Pete Vuckovich (9-7) L: Tony Brizzolara (5-5) | Fifth | 7 out |
| Wednesday, July 25 |
| » Lost to Braves (42-59), 13-4 | Busch Stadium II (29-23) | 46-47 | |
| » W: Joey McLaughlin (3-1) L: George Frazier (1-2) | Fifth | 8 out |
| Thursday, July 26 |
| » Defeated Braves (42-60), 6-2 | Busch Stadium II (30-23) | 47-47 | |
| » W: Silvio Martinez (9-3) L: Eddie Solomon (4-8) | Fifth | 7½ out |
| Friday, July 27 |
| » Defeated Phillies (52-47), 5-0 | Veteran's Stadium (2-2) | 48-47 | Won 2 |
| » W: Bob Forsch (4-9) L: Nino Espinosa (10-8) | Fifth | 6 out |
| Saturday, July 28 |
| » Defeated Phillies (52-48), 5-4 | Veteran's Stadium (3-2) | 49-47 | Won 3 |
| » W: Mark Littell (7-3) L: Ron Reed (6-6) | Fifth | 5½ out |
| Sunday, July 29 |
| » Defeated Phillies (52-49), 6-5 | Veteran's Stadium (4-2) | 50-47 | Won 4 |
| » W: Pete Vuckovich (10-7) L: Randy Lerch (6-10) | Fifth | 5 out |
| Monday, July 30 |
| » Defeated Expos (55-43), 7-2 | Stade Olympique (2-1) | 51-47 | Won 5 |
| » W: John Denny (5-8) L: Bill Lee (10-7) | Fifth | 5 out |
| » Lost to Expos (56-43), 5-1 | Stade Olympique (2-2) | 51-48 | |
| » W: David Palmer (3-2) L: Roy Thomas (0-1) S: Stan Bahnsen (3) | Fifth | 5 out |
| Tuesday, July 31 |
| » Lost to Expos (57-43), 5-0 | Stade Olympique (2-3) | 51-49 | Lost 2 |
| » W: Rudy May (6-0) L: Silvio Martinez (9-4) | Fifth | 6 out |
| Wednesday, August 1 |
| » Lost to Pirates (58-45), 4-3 | Three Rivers Stadium (1-4) | 51-50 | Lost 3 |
| » W: Enrique Romo (6-3) L: Bob Forsch (4-10) S: Kent Tekulve (19) | Fifth | 7 out |
| Thursday, August 2 |
| » Defeated Pirates (58-46), 5-4 | Three Rivers Stadium (2-4) | 52-50 | |
| » W: George Frazier (2-2) L: Grant Jackson (6-3) S: Darold Knowles (6) | Fifth | 7 out |
| Friday, August 3 |
| » Lost to Cubs (55-48), 4-2 | Wrigley Field (1-3) | 52-51 | |
| » W: Rick Reuschel (10-7) L: Pete Vuckovich (10-8) S: Bruce Sutter (24) | Fifth | 8 out |
| Saturday, August 4 |
| » Lost to Cubs (56-48), 8-6 | Wrigley Field (1-4) | 52-52 | Lost 2 |
| » W: Mike Krukow (9-6) L: John Denny (5-9) S: Bruce Sutter (25) | Fifth | 8 out |
| Sunday, August 5 |
| » Lost to Cubs (57-48), 3-2 | Wrigley Field (1-5) | 52-53 | Lost 3 |
| » W: Willie Hernandez (3-1) L: Silvio Martinez (9-5) S: Bruce Sutter (26) | Fifth | 8½ out |
| » Defeated Cubs (57-49), 5-4 | Wrigley Field (2-5) | 53-53 | |
| » W: Bob Forsch (5-10) L: Ken Holtzman (6-9) S: Mark Littell (6) | Fifth | 8½ out |
| Tuesday, August 7 |
| » Defeated Mets (47-61), 9-2 | Shea Stadium (2-1) | 54-53 | Won 2 |
| » W: John Fulgham (4-3) L: Kevin Kobel (5-6) | Fifth | 7 out |
| » Defeated Mets (47-62), 2-1 | Shea Stadium (3-1) | 55-53 | Won 3 |
| » W: Roy Thomas (1-1) L: Pete Falcone (3-8) S: Will McEnaney (1) | Fifth | 7 out |
| Wednesday, August 8 |
| » Defeated Mets (47-63), 8-4 | Shea Stadium (4-1) | 56-53 | Won 4 |
| » W: Pete Vuckovich (11-8) L: Andy Hassler (4-6) | Fourth | 7 out |
| Thursday, August 9 |
| » Defeated Mets (47-64), 4-0 | Shea Stadium (5-1) | 57-53 | Won 5 |
| » W: John Denny (6-9) L: Dock Ellis (3-10) | Fifth | 6 out |
| Friday, August 10 |
| » Defeated Cubs (59-51), 13-8 | Busch Stadium II (31-23) | 58-53 | Won 6 |
| » W: Silvio Martinez (10-5) L: Mike Krukow (9-7) | Fourth | 5 out |
| » Defeated Cubs (59-52), 5-3 | Busch Stadium II (32-23) | 59-53 | Won 7 |
| » W: Bob Forsch (6-10) L: Bill Caudill (0-4) S: Mark Littell (7) | Fourth | 5 out |
| Saturday, August 11 |
| » Lost to Cubs (60-52), 7-3 | Busch Stadium II (32-24) | 59-54 | |
| » W: Rick Reuschel (12-7) L: Roy Thomas (1-2) S: Bruce Sutter (27) | Fourth | 6 out |
| Sunday, August 12 |
| » Lost to Cubs (61-52), 5-3 | Busch Stadium II (32-25) | 59-55 | Lost 2 |
| » W: Willie Hernandez (4-1) L: John Fulgham (4-4) S: Bruce Sutter (28) | Fourth | 6½ out |
| Monday, August 13 |
| » Defeated Cubs (61-53), 3-2 | Busch Stadium II (33-25) | 60-55 | |
| » W: Mark Littell (8-3) L: Willie Hernandez (4-2) | Fourth | 6½ out |
| » Major-league debuts: Tom Herr (Cardinals) |
| Tuesday, August 14 |
| » Lost to Dodgers (53-65), 9-0 | Busch Stadium II (33-26) | 60-56 | |
| » W: Burt Hooton (11-8) L: John Denny (6-10) | Fourth | 7½ out |
| Wednesday, August 15 |
| » Lost to Dodgers (54-65), 6-5 | Busch Stadium II (33-27) | 60-57 | Lost 2 |
| » W: Rick Sutcliffe (11-8) L: Silvio Martinez (10-6) S: Ken Brett (1) | Fourth | 8½ out |
| Thursday, August 16 |
| » Lost to Dodgers (55-65), 4-2 | Busch Stadium II (33-28) | 60-58 | Lost 3 |
| » W: Bobby Castillo (1-0) L: George Frazier (2-3) | Fifth | 9½ out |
| Friday, August 17 |
| » Defeated Giants (57-65), 3-0 | Busch Stadium II (34-28) | 61-58 | |
| » W: John Fulgham (5-4) L: Ed Whitson (5-8) | Fourth | 8½ out |
| Saturday, August 18 |
| » Defeated Giants (57-66), 5-4 | Busch Stadium II (35-28) | 62-58 | Won 2 |
| » W: Roy Thomas (2-2) L: Vida Blue (10-10) | Fourth | 7½ out |
| Sunday, August 19 |
| » Defeated Giants (57-67), 4-0 | Busch Stadium II (36-28) | 63-58 | Won 3 |
| » W: John Denny (7-10) L: John Curtis (8-8) S: Mark Littell (8) | Fourth | 7½ out |
| Monday, August 20 |
| » Defeated Padres (53-73), 6-3 | Busch Stadium II (37-28) | 64-58 | Won 4 |
| » W: Silvio Martinez (11-6) L: Gaylord Perry (10-11) | Fourth | 7½ out |
| Tuesday, August 21 |
| » Lost to Padres (54-73), 3-2 | Busch Stadium II (37-29) | 64-59 | |
| » W: Bob Shirley (6-12) L: Will McEnaney (0-2) S: Rollie Fingers (13) | Fourth | 7½ out |
| Wednesday, August 22 |
| » Defeated Padres (54-74), 8-5 | Busch Stadium II (38-29) | 65-59 | |
| » W: John Fulgham (6-4) L: Bob Owchinko (4-8) | Fourth | 7½ out |
| Friday, August 24 |
| » Defeated Dodgers (59-68), 12-5 | Dodger Stadium (2-2) | 66-59 | Won 2 |
| » W: Pete Vuckovich (12-8) L: Jerry Reuss (4-11) | Fourth | 6½ out |
| Saturday, August 25 |
| » Defeated Dodgers (59-69), 5-4 | Dodger Stadium (3-2) | 67-59 | Won 3 |
| » W: Roy Thomas (3-2) L: Ken Brett (3-3) | Fourth | 6½ out |
| Sunday, August 26 |
| » Lost to Dodgers (60-69), 4-1 | Dodger Stadium (3-3) | 67-60 | |
| » W: Rick Sutcliffe (12-9) L: Silvio Martinez (11-7) S: Bobby Castillo (4) | Fourth | 7½ out |
| Tuesday, August 28 |
| » Defeated Giants (59-72), 2-1 | Candlestick Park (1-3) | 68-60 | |
| » W: Bob Forsch (7-10) L: Bob Knepper (9-9) S: Mark Littell (9) | Fourth | 7 out |
| Wednesday, August 29 |
| » Defeated Giants (59-73), 5-1 | Candlestick Park (2-3) | 69-60 | Won 2 |
| » W: John Fulgham (7-4) L: Vida Blue (10-12) | Fourth | 7 out |
| Thursday, August 30 |
| » Lost to Giants (60-73), 3-2 | Candlestick Park (2-4) | 69-61 | |
| » W: Ed Whitson (6-8) L: Pete Vuckovich (12-9) | Fourth | 7½ out |
| Friday, August 31 |
| » Defeated Padres (57-78), 8-7 | San Diego/Jack Murphy Stadium (2-2) | 70-61 | |
| » W: Dan O'Brien (1-0) L: Bob Owchinko (4-9) | Fourth | 7½ out |
| Saturday, September 1 |
| » Defeated Padres (57-79), 5-3 | San Diego/Jack Murphy Stadium (3-2) | 71-61 | Won 2 |
| » W: Silvio Martinez (12-7) L: Randy Jones (10-11) | Third | 8 out |
| Sunday, September 2 |
| » Defeated Padres (57-80), 2-1 | San Diego/Jack Murphy Stadium (4-2) | 72-61 | Won 3 |
| » W: Bob Forsch (8-10) L: Mark Lee (2-3) | Third | 8 out |
| Monday, September 3 |
| » Defeated Cubs (71-63), 2-1 | Wrigley Field (3-5) | 73-61 | Won 4 |
| » W: John Fulgham (8-4) L: Dennis Lamp (10-8) | Third | 7½ out |
| Tuesday, September 4 |
| » Defeated Cubs (71-64), 6-4 | Wrigley Field (4-5) | 74-61 | Won 5 |
| » W: Pete Vuckovich (13-9) L: Willie Hernandez (4-4) | Third | 7 out |
| Wednesday, September 5 |
| » Lost to Pirates (83-55), 7-5 | Busch Stadium II (38-30) | 74-62 | |
| » W: Dave Roberts (3-3) L: Roy Thomas (3-3) S: Kent Tekulve (26) | Third | 8 out |
| Thursday, September 6 |
| » Defeated Pirates (83-56), 8-6 | Busch Stadium II (39-30) | 75-62 | |
| » W: Silvio Martinez (13-7) L: Jim Bibby (10-4) S: Will McEnaney (2) | Third | 7 out |
| Friday, September 7 |
| » Defeated Expos (79-55), 5-4 | Busch Stadium II (40-30) | 76-62 | Won 2 |
| » W: Bob Forsch (9-10) L: Steve Rogers (12-9) S: Mark Littell (10) | Third | 7 out |
| Saturday, September 8 |
| » Lost to Expos (80-55), 7-2 | Busch Stadium II (40-31) | 76-63 | |
| » W: Bill Lee (15-10) L: John Fulgham (8-5) | Third | 7 out |
| Sunday, September 9 |
| » Lost to Expos (81-55), 4-1 | Busch Stadium II (40-32) | 76-64 | Lost 2 |
| » W: Rudy May (9-2) L: Pete Vuckovich (13-10) S: Woodie Fryman (9) | Third | 8 out |
| Tuesday, September 11 |
| » Lost to Pirates (86-57), 7-3 | Three Rivers Stadium (2-5) | 76-65 | Lost 3 |
| » W: Dave Roberts (4-3) L: John Denny (7-11) | Third | 9 out |
| Wednesday, September 12 |
| » Lost to Pirates (87-57), 2-0 | Three Rivers Stadium (2-6) | 76-66 | Lost 4 |
| » W: John Candelaria (14-8) L: Bob Forsch (9-11) S: Kent Tekulve (27) | Third | 10 out |
| Saturday, September 15 |
| » Lost to Expos (86-55), 2-1 | Stade Olympique (2-4) | 76-67 | Lost 5 |
| » W: Elias Sosa (7-7) L: Will McEnaney (0-3) | Third | 10½ out |
| » Defeated Expos (86-56), 4-1 | Stade Olympique (3-4) | 77-67 | |
| » W: John Fulgham (9-5) L: Rudy May (9-3) | Third | 10½ out |
| Sunday, September 16 |
| » Defeated Expos (86-57), 4-3 | Stade Olympique (4-4) | 78-67 | Won 2 |
| » W: Silvio Martinez (14-7) L: Ross Grimsley (8-9) S: Mark Littell (11) | Third | 10 out |
| » Lost to Expos (87-57), 5-1 | Stade Olympique (4-5) | 78-68 | |
| » W: Scott Sanderson (8-7) L: Roy Thomas (3-4) | Third | 10 out |
| Monday, September 17 |
| » Lost to Phillies (77-72), 7-5 | Busch Stadium II (40-33) | 78-69 | Lost 2 |
| » W: Steve Carlton (16-11) L: Darold Knowles (2-5) S: Tug McGraw (16) | Third | 11 out |
| Tuesday, September 18 |
| » Lost to Phillies (78-72), 5-3 | Busch Stadium II (40-34) | 78-70 | Lost 3 |
| » W: Tug McGraw (4-3) L: Dan O'Brien (1-1) | Third | 12 out |
| Wednesday, September 19 |
| » Defeated Cubs (76-74), 6-3 | Busch Stadium II (41-34) | 79-70 | |
| » W: Pete Vuckovich (14-10) L: Doug Capilla (1-1) S: Mark Littell (12) | Third | 12 out |
| » Lost to Cubs (77-74), 3-2 | Busch Stadium II (41-35) | 79-71 | |
| » W: Bruce Sutter (6-6) L: John Fulgham (9-6) S: Dick Tidrow (6) | Third | 12 out |
| Thursday, September 20 |
|