| Wednesday, April 4 |
| » Major-league debuts: Mark Clear (Angels) |
| Thursday, April 5 |
| » Lost to Royals (1-0), 11-2 | Royals Stadium (0-1) | 0-1 | |
| » W: Dennis Leonard (1-0) L: Tom Underwood (0-1) S: Steve Mingori (1) | Third | 1 out |
| » Major-league debuts: Bobby Brown (Blue Jays) |
| Saturday, April 7 |
| » Lost to Royals (2-0), 7-4 | Royals Stadium (0-2) | 0-2 | Lost 2 |
| » W: Larry Gura (1-0) L: Jim Clancy (0-1) S: Al Hrabosky (1) | Fourth | 2 out |
| Sunday, April 8 |
| » Lost to Royals (3-0), 8-3 | Royals Stadium (0-3) | 0-3 | Lost 3 |
| » W: Paul Splittorff (1-0) L: Mark Lemongello (0-1) | Fourth | 2 out |
| Tuesday, April 10 |
| » Defeated White Sox (1-3), 10-2 | Comiskey Park I (1-0) | 1-3 | |
| » W: Phil Huffman (1-0) L: Ken Kravec (0-2) S: Dave Freisleben (1) | Fourth | 2 out |
| » Major-league debuts: Phil Huffman (Blue Jays) |
| Thursday, April 12 |
| » Defeated White Sox (1-4), 9-7 | Comiskey Park I (2-0) | 2-3 | Won 2 |
| » W: Tom Murphy (1-0) L: Lerrin LaGrow (0-1) | Third | 1 out |
| Friday, April 13 |
| » Defeated Royals (4-2), 4-1 | Exhibition Stadium (1-0) | 3-3 | Won 3 |
| » W: Jim Clancy (1-1) L: Paul Splittorff (1-1) | Third | 1 out |
| Saturday, April 14 |
| » Defeated Royals (4-3), 8-6 | Exhibition Stadium (2-0) | 4-3 | Won 4 |
| » W: Dave Freisleben (1-0) L: Dennis Leonard (1-1) | Third | 1 out |
| Sunday, April 15 |
| » Lost to Royals (5-3), 12-10 | Exhibition Stadium (2-1) | 4-4 | |
| » W: Eduardo Rodriguez (2-0) L: Tom Murphy (1-1) S: Al Hrabosky (2) | Fourth | 2 out |
| Monday, April 16 |
| » Lost to White Sox (3-6), 8-4 | Exhibition Stadium (2-2) | 4-5 | Lost 2 |
| » W: Randy Scarbery (1-0) L: Tom Murphy (1-2) S: Mike Proly (1) | Fourth | 2½ out |
| » Major-league debuts: Randy Scarbery (White Sox) |
| Tuesday, April 17 |
| » Lost to White Sox (4-6), 6-1 | Exhibition Stadium (2-3) | 4-6 | Lost 3 |
| » W: Francisco Barrios (1-0) L: Tom Underwood (0-2) S: Mike Proly (2) | Fifth | 2½ out |
| Wednesday, April 18 |
| » Lost to White Sox (5-6), 12-5 | Exhibition Stadium (2-4) | 4-7 | Lost 4 |
| » W: Rich Wortham (3-0) L: Jim Clancy (1-2) | Fifth | 3½ out |
| Friday, April 20 |
| » Lost to Tigers (5-4), 7-2 | Tiger Stadium (0-1) | 4-8 | Lost 5 |
| » W: Milt Wilcox (2-0) L: Mark Lemongello (0-2) | Sixth | 3½ out |
| Saturday, April 21 |
| » Defeated Tigers (5-5), 5-4 | Tiger Stadium (1-1) | 5-8 | |
| » W: Phil Huffman (2-0) L: Jack Billingham (1-1) S: Dave Freisleben (2) | Sixth | 3½ out |
| Sunday, April 22 |
| » Lost to Tigers (6-5), 4-1 | Tiger Stadium (1-2) | 5-9 | |
| » W: Dave Rozema (1-1) L: Tom Underwood (0-3) | Sixth | 4½ out |
| Monday, April 23 |
| » Lost to Rangers (9-4), 5-0 | Arlington Stadium (0-1) | 5-10 | Lost 2 |
| » W: Doyle Alexander (1-0) L: Jim Clancy (1-3) S: Jim Kern (2) | Sixth | 5 out |
| Tuesday, April 24 |
| » Defeated Rangers (9-5), 2-0 | Arlington Stadium (1-1) | 6-10 | |
| » W: Dave Lemanczyk (1-0) L: Steve Comer (1-2) | Sixth | 5 out |
| Wednesday, April 25 |
| » Lost to Rangers (10-5), 4-3 | Arlington Stadium (1-2) | 6-11 | |
| » W: Sparky Lyle (2-1) L: Jesse Jefferson (0-1) | Sixth | 6 out |
| Friday, April 27 |
| » Lost to Brewers (10-8), 8-5 | Exhibition Stadium (2-5) | 6-12 | Lost 2 |
| » W: Lary Sorensen (3-2) L: Phil Huffman (2-1) S: Bob McClure (1) | Fifth | 6½ out |
| Saturday, April 28 |
| » Lost to Brewers (11-8), 11-8 | Exhibition Stadium (2-6) | 6-13 | Lost 3 |
| » W: Bob McClure (3-0) L: Mike Willis (0-1) | Sixth | 6½ out |
| Sunday, April 29 |
| » Lost to Brewers (12-8), 3-0 | Exhibition Stadium (2-7) | 6-14 | Lost 4 |
| » W: Mike Caldwell (4-1) L: Jim Clancy (1-4) | Sixth | 7 out |
| » Defeated Brewers (12-9), 5-3 | Exhibition Stadium (3-7) | 7-14 | |
| » W: Dave Lemanczyk (2-0) L: Bill Travers (0-2) | Sixth | 7 out |
| Monday, April 30 |
| » Lost to Twins (13-7), 6-3 | Exhibition Stadium (3-8) | 7-15 | |
| » W: Paul Hartzell (1-0) L: Mark Lemongello (0-3) | Sixth | 7 out |
| Tuesday, May 1 |
| » Lost to Twins (14-7), 3-2 | Exhibition Stadium (3-9) | 7-16 | Lost 2 |
| » W: Jerry Koosman (5-0) L: Jesse Jefferson (0-2) S: Mike Marshall (8) | Seventh | 7½ out |
| Wednesday, May 2 |
| » Lost to Twins (15-7), 7-5 | Exhibition Stadium (3-10) | 7-17 | Lost 3 |
| » W: Dave Goltz (3-3) L: Phil Huffman (2-2) S: Mike Marshall (9) | Seventh | 8½ out |
| Thursday, May 3 |
| » Lost to Brewers (15-10), 5-4 | County Stadium (0-1) | 7-18 | Lost 4 |
| » W: Bill Travers (1-2) L: Tom Underwood (0-4) | Seventh | 9 out |
| Friday, May 4 |
| » Defeated Brewers (15-11), 5-4 | County Stadium (1-1) | 8-18 | |
| » W: Jim Clancy (2-4) L: Mike Caldwell (4-2) S: Dave Freisleben (3) | Sixth | 8½ out |
| Saturday, May 5 |
| » Lost to Brewers (16-11), 6-1 | County Stadium (1-2) | 8-19 | |
| » W: Jim Slaton (3-1) L: Dave Lemanczyk (2-1) | Sixth | 9½ out |
| Sunday, May 6 |
| » Lost to Brewers (17-11), 4-0 | County Stadium (1-3) | 8-20 | Lost 2 |
| » W: Lary Sorensen (4-3) L: Mark Lemongello (0-4) | Seventh | 10½ out |
| Monday, May 7 |
| » Lost to Twins (19-8), 6-1 | Metropolitan Stadium (0-1) | 8-21 | Lost 3 |
| » W: Dave Goltz (4-3) L: Phil Huffman (2-3) | Seventh | 10½ out |
| Tuesday, May 8 |
| » Lost to Twins (20-8), 16-6 | Metropolitan Stadium (0-2) | 8-22 | Lost 4 |
| » W: Mike Bacsik (1-0) L: Mike Willis (0-2) | Seventh | 11½ out |
| Wednesday, May 9 |
| » Major-league debuts: Renie Martin (Royals) |
| Friday, May 11 |
| » Lost to Rangers (16-13), 3-1 | Exhibition Stadium (3-11) | 8-23 | Lost 5 |
| » W: Jon Matlack (1-2) L: Jim Clancy (2-5) | Seventh | 12½ out |
| Saturday, May 12 |
| » Lost to Rangers (17-13), 3-1 | Exhibition Stadium (3-12) | 8-24 | Lost 6 |
| » W: Steve Comer (3-3) L: Dave Lemanczyk (2-2) S: Sparky Lyle (5) | Seventh | 13½ out |
| Sunday, May 13 |
| » Defeated Rangers (17-14), 3-1 | Exhibition Stadium (4-12) | 9-24 | |
| » W: Mark Lemongello (1-4) L: Doyle Alexander (1-2) | Seventh | 13½ out |
| » Lost to Rangers (18-14), 7-5 | Exhibition Stadium (4-13) | 9-25 | |
| » W: Ed Farmer (2-0) L: Phil Huffman (2-4) S: Sparky Lyle (6) | Seventh | 13½ out |
| Monday, May 14 |
| » Lost to Indians (12-20), 1-0 | Cleveland Stadium (0-1) | 9-26 | Lost 2 |
| » W: Rick Waits (4-3) L: Tom Underwood (0-5) | Seventh | 14 out |
| Tuesday, May 15 |
| » Lost to Indians (13-20), 5-3 | Cleveland Stadium (0-2) | 9-27 | Lost 3 |
| » W: Sid Monge (2-3) L: Jerry Garvin (0-1) | Seventh | 14½ out |
| Wednesday, May 16 |
| » Defeated Indians (13-21), 4-3 | Cleveland Stadium (1-2) | 10-27 | |
| » W: Dave Lemanczyk (3-2) L: Rick Wise (3-4) | Sixth | 14 out |
| Thursday, May 17 |
| » Lost to Indians (14-21), 8-3 | Cleveland Stadium (1-3) | 10-28 | |
| » W: Mike Paxton (3-2) L: Mark Lemongello (1-5) | Seventh | 14½ out |
| Friday, May 18 |
| » Lost to Orioles (24-13), 7-6 | Exhibition Stadium (4-14) | 10-29 | Lost 2 |
| » W: Don Stanhouse (3-1) L: Dave Freisleben (1-1) | Seventh | 15 out |
| Saturday, May 19 |
| » Lost to Orioles (25-13), 4-3 | Exhibition Stadium (4-15) | 10-30 | Lost 3 |
| » W: Jim Palmer (5-2) L: Tom Underwood (0-6) S: Don Stanhouse (4) | Seventh | 16 out |
| Sunday, May 20 |
| » Lost to Orioles (26-13), 6-2 | Exhibition Stadium (4-16) | 10-31 | Lost 4 |
| » W: Dennis Martinez (6-2) L: Jesse Jefferson (0-3) | Seventh | 17 out |
| Future Blue Jay Jayson Werth is born in Springfield, IL. |
| Monday, May 21 |
| » Defeated Indians (16-23), 8-1 | Exhibition Stadium (5-16) | 11-31 | |
| » W: Dave Lemanczyk (4-2) L: Rick Wise (3-5) | Seventh | 16½ out |
| » Major-league debuts: Danny Ainge (Blue Jays) |
| Tuesday, May 22 |
| » Lost to Indians (17-23), 8-6 | Exhibition Stadium (5-17) | 11-32 | |
| » W: Eric Wilkins (2-2) L: Mark Lemongello (1-6) S: Sid Monge (5) | Seventh | 16½ out |
| Wednesday, May 23 |
| » Lost to Indians (18-23), 4-3 | Exhibition Stadium (5-18) | 11-33 | Lost 2 |
| » W: Wayne Garland (2-4) L: Dave Freisleben (1-2) | Seventh | 17½ out |
| Saturday, May 26 |
| » Defeated Red Sox (25-17), 7-6 | Exhibition Stadium (6-18) | 12-33 | |
| » W: Tom Buskey (1-0) L: Bill Campbell (2-2) | Seventh | 18 out |
| Sunday, May 27 |
| » Lost to Red Sox (26-17), 1-0 | Exhibition Stadium (6-19) | 12-34 | |
| » W: Chuck Rainey (3-2) L: Jesse Jefferson (0-4) | Seventh | 17½ out |
| Monday, May 28 |
| » Lost to Tigers (19-21), 6-2 | Exhibition Stadium (6-20) | 12-35 | Lost 2 |
| » W: Jack Morris (2-1) L: Dave Lemanczyk (4-3) | Seventh | 17½ out |
| Tuesday, May 29 |
| » Lost to Tigers (20-21), 9-8 | Exhibition Stadium (6-21) | 12-36 | Lost 3 |
| » W: Dave Tobik (1-0) L: Tom Buskey (1-1) S: John Hiller (3) | Seventh | 18½ out |
| Wednesday, May 30 |
| » Lost to Tigers (21-21), 8-2 | Exhibition Stadium (6-22) | 12-37 | Lost 4 |
| » W: Milt Wilcox (4-2) L: Phil Huffman (2-5) | Seventh | 18½ out |
| Thursday, May 31 |
| » Lost to Tigers (22-21), 1-0 | Exhibition Stadium (6-23) | 12-38 | Lost 5 |
| » W: Pat Underwood (1-0) L: Tom Underwood (0-7) S: John Hiller (4) | Seventh | 19 out |
| » Major-league debuts: Pat Underwood (Tigers) |
| Friday, June 1 |
| » Lost to Mariners (19-33), 7-2 | Kingdome (0-1) | 12-39 | Lost 6 |
| » W: Paul Mitchell (1-4) L: Jesse Jefferson (0-5) | Seventh | 19 out |
| Saturday, June 2 |
| » Defeated Mariners (19-34), 6-2 | Kingdome (1-1) | 13-39 | |
| » W: Dave Lemanczyk (5-3) L: Odell Jones (0-6) | Seventh | 19 out |
| Sunday, June 3 |
| » Lost to Mariners (20-34), 10-5 | Kingdome (1-2) | 13-40 | |
| » W: Mike Parrott (3-1) L: Mark Lemongello (1-7) | Seventh | 19 out |
| Monday, June 4 |
| » Lost to Angels (32-22), 4-2 | Anaheim Stadium (0-1) | 13-41 | Lost 2 |
| » W: Mike Barlow (1-1) L: Phil Huffman (2-6) S: Mark Clear (5) | Seventh | 20 out |
| Tuesday, June 5 |
| » Lost to Angels (33-22), 3-0 | Anaheim Stadium (0-2) | 13-42 | Lost 3 |
| » W: Frank Tanana (5-3) L: Tom Underwood (0-8) | Seventh | 20 out |
| Wednesday, June 6 |
| » Defeated Angels (33-23), 5-4 | Anaheim Stadium (1-2) | 14-42 | |
| » W: Jesse Jefferson (1-5) L: Dave LaRoche (2-5) | Seventh | 20 out |
| Friday, June 8 |
| » Defeated Athletics (18-39), 2-1 | Oakland-Alameda County Stadium (1-0) | 15-42 | Won 2 |
| » W: Tom Buskey (2-1) L: Dave Heaverlo (2-6) | Seventh | 20½ out |
| Saturday, June 9 |
| » Defeated Athletics (18-40), 5-0 | Oakland-Alameda County Stadium (2-0) | 16-42 | Won 3 |
| » W: Phil Huffman (3-6) L: Matt Keough (0-8) | Seventh | 20½ out |
| Sunday, June 10 |
| » Lost to Athletics (19-40), 12-1 | Oakland-Alameda County Stadium (2-1) | 16-43 | |
| » W: Dave Hamilton (2-0) L: Tom Underwood (0-9) | Seventh | 21½ out |
| Monday, June 11 |
| » Defeated Mariners (24-37), 2-0 | Exhibition Stadium (7-23) | 17-43 | |
| » W: Dave Lemanczyk (6-3) L: Floyd Bannister (3-6) | Seventh | 21½ out |
| Tuesday, June 12 |
| » Lost to Mariners (25-37), 5-1 | Exhibition Stadium (7-24) | 17-44 | |
| » W: Glenn Abbott (3-7) L: Jesse Jefferson (1-6) | Seventh | 21½ out |
| Wednesday, June 13 |
| » Defeated Angels (36-26), 9-8 | Exhibition Stadium (8-24) | 18-44 | |
| » W: Dave Freisleben (2-2) L: Dave LaRoche (2-6) | Seventh | 22 out |
| » Lost to Angels (37-26), 10-2 | Exhibition Stadium (8-25) | 18-45 | |
| » W: Don Aase (6-4) L: Mike Willis (0-3) | Seventh | 22 out |
| Thursday, June 14 |
| » Lost to Angels (38-26), 10-2 | Exhibition Stadium (8-26) | 18-46 | Lost 2 |
| » W: Nolan Ryan (8-3) L: Phil Huffman (3-7) | Seventh | 22½ out |
| Friday, June 15 |
| » Defeated Athletics (19-45), 6-0 | Exhibition Stadium (9-26) | 19-46 | |
| » W: Tom Underwood (1-9) L: Dave Hamilton (2-1) | Seventh | 22½ out |
| Saturday, June 16 |
| » Defeated Athletics (19-46), 3-2 | Exhibition Stadium (10-26) | 20-46 | Won 2 |
| » W: Dave Lemanczyk (7-3) L: Steve McCatty (4-2) | Seventh | 22 out |
| Sunday, June 17 |
| » Defeated Athletics (19-47), 10-9 | Exhibition Stadium (11-26) | 21-46 | Won 3 |
| » W: Tom Buskey (3-1) L: Dave Heaverlo (2-7) | Seventh | 22 out |
| Tuesday, June 19 |
| » Defeated Yankees (34-32), 5-4 | Yankee Stadium (1-0) | 22-46 | Won 4 |
| » W: Phil Huffman (4-7) L: Tommy John (10-3) S: Tom Buskey (1) | Seventh | 22½ out |
| Wednesday, June 20 |
| » Lost to Yankees (35-32), 2-1 | Yankee Stadium (1-1) | 22-47 | |
| » W: Don Hood (2-0) L: Tom Underwood (1-10) S: Ron Davis (1) | Seventh | 23 out |
| » Defeated Yankees (35-33), 3-2 | Yankee Stadium (2-1) | 23-47 | |
| » W: Balor Moore (1-0) L: Ray Burris (1-3) | Seventh | 23 out |
| Thursday, June 21 |
| » Lost to Yankees (36-33), 3-1 | Yankee Stadium (2-2) | 23-48 | |
| » W: Luis Tiant (3-2) L: Dave Lemanczyk (7-4) S: Ron Davis (2) | Seventh | 23½ out |
| Friday, June 22 |
| » Lost to Red Sox (42-25), 12-1 | Fenway Park (0-1) | 23-49 | Lost 2 |
| » W: Chuck Rainey (5-4) L: Jesse Jefferson (1-7) S: Tom Burgmeier (2) | Seventh | 24½ out |
| Saturday, June 23 |
| » Lost to Red Sox (43-25), 4-3 | Fenway Park (0-2) | 23-50 | Lost 3 |
| » W: Dick Drago (6-3) L: Tom Buskey (3-2) | Seventh | 26 out |
| Sunday, June 24 |
| » Lost to Red Sox (44-25), 8-4 | Fenway Park (0-3) | 23-51 | Lost 4 |
| » W: Mike Torrez (8-4) L: Phil Huffman (4-8) | Seventh | 26 out |
| Monday, June 25 |
| » Defeated Yankees (39-34), 3-1 | Exhibition Stadium (12-26) | 24-51 | |
| » W: Tom Underwood (2-10) L: Ken Clay (1-3) | Seventh | 26 out |
| Tuesday, June 26 |
| » Lost to Yankees (40-34), 11-2 | Exhibition Stadium (12-27) | 24-52 | |
| » W: Luis Tiant (4-2) L: Dave Lemanczyk (7-5) | Seventh | 27 out |
| Thursday, June 28 |
| » Lost to Yankees (41-34), 5-3 | Exhibition Stadium (12-28) | 24-53 | Lost 2 |
| » W: Ron Davis (6-0) L: Mark Lemongello (1-8) | Seventh | 27½ out |
| Friday, June 29 |
| » Lost to Orioles (51-24), 6-1 | Memorial Stadium (0-1) | 24-54 | Lost 3 |
| » W: Scott McGregor (2-2) L: Dave Stieb (0-1) | Seventh | 29½ out |
| » Lost to Orioles (52-24), 4-0 | Memorial Stadium (0-2) | 24-55 | Lost 4 |
| » W: Steve Stone (6-5) L: Phil Huffman (4-9) S: Don Stanhouse (9) | Seventh | 29½ out |
| » Major-league debuts: Dave Stieb (Blue Jays) |
| Saturday, June 30 |
| » Lost to Orioles (53-24), 2-0 | Memorial Stadium (0-3) | 24-56 | Lost 5 |
| » W: Mike Flanagan (10-5) L: Tom Underwood (2-11) | Seventh | 30½ out |
| Sunday, July 1 |
| » Lost to Orioles (54-24), 10-7 | Memorial Stadium (0-4) | 24-57 | Lost 6 |
| » W: Sammy Stewart (5-2) L: Jesse Jefferson (1-8) S: Don Stanhouse (10) | Seventh | 31½ out |
| Tuesday, July 3 |
| » Defeated Tigers (36-39), 9-1 | Tiger Stadium (2-2) | 25-57 | |
| » W: Balor Moore (2-0) L: Jack Billingham (7-5) | Seventh | 30 out |
| Wednesday, July 4 |
| » Defeated Tigers (36-40), 7-6 | Tiger Stadium (3-2) | 26-57 | Won 2 |
| » W: Tom Buskey (4-2) L: Dave Tobik (1-4) | Seventh | 29 out |
| Thursday, July 5 |
| » Lost to Tigers (37-40), 3-2 | Tiger Stadium (3-3) | 26-58 | |
| » W: Kip Young (2-1) L: Phil Huffman (4-10) S: Aurelio Lopez (2) | Seventh | 29½ out |
| Friday, July 6 |
| » Defeated Rangers (47-35), 5-1 | Arlington Stadium (2-2) | 27-58 | |
| » W: Tom Underwood (3-11) L: John Henry Johnson (4-9) S: Tom Buskey (2) | Seventh | 28½ out |
| Saturday, July 7 |
| » Lost to Rangers (48-35), 2-0 | Arlington Stadium (2-3) | 27-59 | |
| » W: Doc Medich (2-3) L: Dave Lemanczyk (7-6) S: Jim Kern (15) | Seventh | 28½ out |
| Sunday, July 8 |
| » Lost to Rangers (49-35), 4-3 | Arlington Stadium (2-4) | 27-60 | Lost 2 |
| » W: Steve Comer (9-6) L: Balor Moore (2-1) S: Sparky Lyle (9) | Seventh | 29½ out |
| Monday, July 9 |
| » Defeated Brewers (49-38), 7-1 | Exhibition Stadium (13-28) | 28-60 | |
| » W: Dave Stieb (1-1) L: Lary Sorensen (10-9) | Seventh | 29½ out |
| Wednesday, July 11 |
| » Lost to Brewers (50-38), 2-1 | Exhibition Stadium (13-29) | 28-61 | |
| » W: Jim Slaton (9-4) L: Tom Buskey (4-3) | Seventh | 30 out |
| Thursday, July 12 |
| » Lost to Brewers (51-38), 5-3 | Exhibition Stadium (13-30) | 28-62 | Lost 2 |
| » W: Moose Haas (6-6) L: Tom Underwood (3-12) S: Bob Galasso (1) | Seventh | 30½ out |
| Friday, July 13 |
| » Lost to Twins (47-40), 6-4 | Exhibition Stadium (13-31) | 28-63 | Lost 3 |
| » W: Dave Goltz (8-6) L: Dave Lemanczyk (7-7) S: Mike Marshall (18) | Seventh | 30½ out |
| Saturday, July 14 |
| » Defeated Twins (47-41), 4-2 | Exhibition Stadium (14-31) | 29-63 | |
| » W: Dave Stieb (2-1) L: Jerry Koosman (11-7) | Seventh | 30½ out |
| Sunday, July 15 |
| » Lost to Twins (48-41), 9-4 | Exhibition Stadium (14-32) | 29-64 | |
| » W: Geoff Zahn (8-2) L: Jim Clancy (2-6) | Seventh | 31½ out |
| Thursday, July 19 |
| » Lost to Brewers (55-38), 3-2 | County Stadium (1-4) | 29-65 | Lost 2 |
| » W: Bill Castro (3-0) L: Tom Buskey (4-4) | Seventh | 32 out |
| Friday, July 20 |
| » Lost to Brewers (56-38), 2-0 | County Stadium (1-5) | 29-66 | Lost 3 |
| » W: Jim Slaton (10-4) L: Tom Underwood (3-13) | Seventh | 33 out |
| Saturday, July 21 |
| » Lost to Twins (50-42), 6-4 | Metropolitan Stadium (0-3) | 29-67 | Lost 4 |
| » W: Dave Goltz (9-6) L: Phil Huffman (4-11) S: Mike Marshall (19) | Seventh | 34½ out |
| » Lost to Twins (51-42), 4-3 | Metropolitan Stadium (0-4) | 29-68 | Lost 5 |
| » W: Paul Hartzell (5-6) L: Balor Moore (2-2) | Seventh | 34½ out |
| Sunday, July 22 |
| » Lost to Twins (52-42), 13-1 | Metropolitan Stadium (0-5) | 29-69 | Lost 6 |
| » W: Pete Redfern (5-0) L: Dave Lemanczyk (7-8) | Seventh | 35½ out |
| Monday, July 23 |
| » Lost to Twins (53-42), 7-6 | Metropolitan Stadium (0-6) | 29-70 | Lost 7 |
| » W: Mike Marshall (10-9) L: Mark Lemongello (1-9) | Seventh | 36½ out |
| Wednesday, July 25 |
| » Defeated Rangers (53-45), 8-3 | Exhibition Stadium (15-32) | 30-70 | |
| » W: Dave Stieb (3-1) L: John Henry Johnson (4-12) S: Tom Buskey (3) | Seventh | 36½ out |
| Thursday, July 26 |
| » Defeated Rangers (53-46), 8-4 | Exhibition Stadium (16-32) | 31-70 | Won 2 |
| » W: Tom Underwood (4-13) L: Doc Medich (4-4) | Seventh | 36½ out |
| Friday, July 27 |
| » Lost to Tigers (50-48), 4-3 | Exhibition Stadium (16-33) | 31-71 | |
| » W: Aurelio Lopez (5-2) L: Tom Buskey (4-5) | Seventh | 37½ out |
| Saturday, July 28 |
| » Defeated Tigers (50-49), 3-0 | Exhibition Stadium (17-33) | 32-71 | |
| » W: Dave Lemanczyk (8-8) L: Bruce Robbins (0-1) | Seventh | 36½ out |
| Sunday, July 29 |
| » Lost to Tigers (51-49), 5-4 | Exhibition Stadium (17-34) | 32-72 | |
| » W: Pat Underwood (6-1) L: Jim Clancy (2-7) S: Aurelio Lopez (8) | Seventh | 37½ out |
| Monday, July 30 |
| » Lost to Royals (51-52), 9-0 | Royals Stadium (0-4) | 32-73 | Lost 2 |
| » W: Larry Gura (7-7) L: Dave Stieb (3-2) | Seventh | 38½ out |
| Tuesday, July 31 |
| » Lost to Royals (52-52), 6-5 | Royals Stadium (0-5) | 32-74 | Lost 3 |
| » W: Marty Pattin (4-2) L: Jesse Jefferson (1-9) S: Al Hrabosky (9) | Seventh | 39½ out |
| Wednesday, August 1 |
| » Lost to Royals (53-52), 4-3 | Royals Stadium (0-6) | 32-75 | Lost 4 |
| » W: Rich Gale (9-8) L: Phil Huffman (4-12) S: Al Hrabosky (10) | Seventh | 40½ out |
| Friday, August 3 |
| » Lost to White Sox (47-59), 8-5 | Exhibition Stadium (17-35) | 32-76 | Lost 5 |
| » W: Steve Trout (6-4) L: Balor Moore (2-3) S: Ed Farmer (5) | Seventh | 41½ out |
| Saturday, August 4 |
| » Defeated White Sox (47-60), 5-2 | Exhibition Stadium (18-35) | 33-76 | |
| » W: Tom Buskey (5-5) L: Rich Wortham (11-11) | Seventh | 41½ out |
| Sunday, August 5 |
| » Lost to White Sox (48-60), 5-4 | Exhibition Stadium (18-36) | 33-77 | |
| » W: Ken Kravec (10-10) L: Dave Lemanczyk (8-9) S: Ed Farmer (6) | Seventh | 41½ out |
| Monday, August 6 |
| » Lost to Royals (56-54), 16-12 | Exhibition Stadium (18-37) | 33-78 | Lost 2 |
| » W: Steve Mingori (3-2) L: Dave Stieb (3-3) | Seventh | 41½ out |
| Tuesday, August 7 |
| » Defeated Royals (56-55), 3-2 | Exhibition Stadium (19-37) | 34-78 | |
| » W: Tom Underwood (5-13) L: Paul Splittorff (10-12) | Seventh | 40½ out |
| Thursday, August 9 |
| » Lost to Royals (57-55), 10-3 | Exhibition Stadium (19-38) | 34-79 | |
| » W: Larry Gura (8-8) L: Phil Huffman (4-13) | Seventh | 41 out |
| Friday, August 10 |
| Future Blue Jay Brandon Lyon is born in Salt Lake City, UT. |
| Saturday, August 11 |
| » Lost to White Sox (51-61), 6-1 | Comiskey Park I (2-1) | 34-80 | Lost 2 |
| » W: Ken Kravec (11-10) L: Jackson Todd (0-1) S: Ed Farmer (8) | Seventh | 41½ out |
| » Defeated White Sox (51-62), 6-0 | Comiskey Park I (3-1) | 35-80 | |
| » W: Dave Stieb (4-3) L: Randy Scarbery (2-7) | Seventh | 41½ out |
| Sunday, August 12 |
| » Lost to White Sox (52-62), 7-0 | Comiskey Park I (3-2) | 35-81 | |
| » W: Ross Baumgarten (10-7) L: Tom Underwood (5-14) | Seventh | 41½ out |
| » Defeated White Sox (52-63), 7-5 | Comiskey Park I (4-2) | 36-81 | |
| » W: Balor Moore (3-3) L: Mike Proly (1-4) S: Tom Buskey (4) | Seventh | 41½ out |
| Monday, August 13 |
| » Defeated Athletics (35-84), 4-2 | Oakland-Alameda County Stadium (3-1) | 37-81 | Won 2 |
| » W: Butch Edge (1-0) L: Mike Norris (3-5) S: Tom Buskey (5) | Seventh | 40½ out |
| Tuesday, August 14 |
| » Defeated Athletics (35-85), 6-2 | Oakland-Alameda County Stadium (4-1) | 38-81 | Won 3 |
| » W: Phil Huffman (5-13) L: Craig Minetto (1-4) | Seventh | 40½ out |
| Wednesday, August 15 |
| » Lost to Athletics (36-85), 3-1 | Oakland-Alameda County Stadium (4-2) | 38-82 | |
| » W: Brian Kingman (3-4) L: Jesse Jefferson (1-10) S: Dave Heaverlo (9) | Seventh | 41½ out |
| Friday, August 17 |
| » Defeated Angels (67-55), 6-5 | Anaheim Stadium (2-2) | 39-82 | |
| » W: Dave Stieb (5-3) L: Mark Clear (10-4) | Seventh | 40 out |
| Saturday, August 18 |
| » Lost to Angels (68-55), 7-5 | Anaheim Stadium (2-3) | 39-83 | |
| » W: Nolan Ryan (13-8) L: Tom Underwood (5-15) S: Mark Clear (13) | Seventh | 41 out |
| Sunday, August 19 |
| » Lost to Angels (69-55), 4-2 | Anaheim Stadium (2-4) | 39-84 | Lost 2 |
| » W: Don Aase (9-8) L: Balor Moore (3-4) | Seventh | 41 out |
| Monday, August 20 |
| » Lost to Mariners (52-73), 7-4 | Kingdome (1-3) | 39-85 | Lost 3 |
| » W: Mike Parrott (11-8) L: Butch Edge (1-1) | Seventh | 42 out |
| Tuesday, August 21 |
| » Lost to Mariners (53-73), 8-4 | Kingdome (1-4) | 39-86 | Lost 4 |
| » W: John Montague (6-4) L: Phil Huffman (5-14) S: Byron McLaughlin (11) | Seventh | 42 out |
| Wednesday, August 22 |
| » Lost to Mariners (54-73), 6-3 | Kingdome (1-5) | 39-87 | Lost 5 |
| » W: Rick Honeycutt (9-9) L: Dave Stieb (5-4) | Seventh | 42½ out |
| Friday, August 24 |
| » Defeated Angels (70-58), 6-4 | Exhibition Stadium (20-38) | 40-87 | |
| » W: Tom Underwood (6-15) L: Chris Knapp (3-3) S: Tom Buskey (6) | Seventh | 42½ out |
| Saturday, August 25 |
| » Lost to Angels (71-58), 24-2 | Exhibition Stadium (20-39) | 40-88 | |
| » W: Dave Frost (13-8) L: Balor Moore (3-5) | Seventh | 43 out |
| Sunday, August 26 |
| » Defeated Angels (71-59), 9-3 | Exhibition Stadium (21-39) | 41-88 | |
| » W: Butch Edge (2-1) L: Nolan Ryan (13-10) | Seventh | 43½ out |
| Monday, August 27 |
| » Defeated Athletics (41-91), 7-0 | Exhibition Stadium (22-39) | 42-88 | Won 2 |
| » W: Phil Huffman (6-14) L: Steve McCatty (8-9) | Seventh | 43 out |
| Tuesday, August 28 |
| » Lost to Athletics (42-91), 6-3 | Exhibition Stadium (22-40) | 42-89 | |
| » W: Rick Langford (10-13) L: Dave Stieb (5-5) | Seventh | 43½ out |
| Wednesday, August 29 |
| » Lost to Athletics (43-91), 6-4 | Exhibition Stadium (22-41) | 42-90 | Lost 2 |
| » W: Mike Norris (5-6) L: Tom Underwood (6-16) | Seventh | 45 out |
| Thursday, August 30 |
| » Lost to Mariners (57-78), 8-2 | Exhibition Stadium (22-42) | 42-91 | Lost 3 |
| » W: Mike Parrott (13-8) L: Balor Moore (3-6) | Seventh | 46 out |
| Friday, August 31 |
| » Defeated Mariners (57-79), 5-4 | Exhibition Stadium (23-42) | 43-91 | |
| » W: Tom Buskey (6-5) L: Byron McLaughlin (6-5) | Seventh | 45 out |
| Saturday, September 1 |
| » Lost to Mariners (58-79), 3-2 | Exhibition Stadium (23-43) | 43-92 | |
| » W: Rick Honeycutt (10-9) L: Tom Buskey (6-6) | Seventh | 45 out |
| Sunday, September 2 |
| » Defeated Mariners (58-80), 8-5 | Exhibition Stadium (24-43) | 44-92 | |
| » W: Dave Stieb (6-5) L: Wayne Twitchell (5-5) S: Jesse Jefferson (1) | Seventh | 45 out |
| Monday, September 3 |
| » Lost to Orioles (89-46), 2-1 | Memorial Stadium (0-5) | 44-93 | |
| » W: Tippy Martinez (9-2) L: Tom Buskey (6-7) | Seventh | 47 out |
| » Lost to Orioles (90-46), 5-1 | Memorial Stadium (0-6) | 44-94 | Lost 2 |
| » W: Mike Flanagan (20-7) L: Dave Lemanczyk (8-10) | Seventh | 47 out |
| Wednesday, September 5 |
| » Major-league debuts: Craig Eaton (Royals) |
| Thursday, September 6 |
| » Lost to Orioles (91-46), 5-0 | Memorial Stadium (0-7) | 44-95 | Lost 3 |
| » W: Dennis Martinez (15-12) L: Butch Edge (2-2) | Seventh | 48 out |
| Friday, September 7 |
| » Lost to Indians (72-69), 9-8 | Cleveland Stadium (1-4) | 44-96 | Lost 4 |
| » W: Paul Reuschel (2-1) L: Tom Buskey (6-8) | Seventh | 49 out |
| Saturday, September 8 |
| » Lost to Indians (73-69), 5-4 | Cleveland Stadium (1-5) | 44-97 | Lost 5 |
| » W: Rick Wise (15-7) L: Dave Stieb (6-6) | Seventh | 50 out |
| Sunday, September 9 |
| » Lost to Indians (74-69), 14-10 | Cleveland Stadium (1-6) | 44-98 | Lost 6 |
| » W: Sid Monge (9-9) L: Tom Buskey (6-9) | Seventh | 51 out |
| Tuesday, September 11 |
| » Defeated Orioles (94-48), 3-1 | Exhibition Stadium (25-43) | 45-98 | |
| » W: Tom Underwood (7-16) L: Scott McGregor (11-5) | Seventh | 49½ out |
| Wednesday, September 12 |
| » Defeated Orioles (94-49), 3-2 | Exhibition Stadium (26-43) | 46-98 | Won 2 |
| » W: Butch Edge (3-2) L: Jim Palmer (8-6) | Seventh | 48½ out |
| Thursday, September 13 |
| » Lost to Orioles (95-49), 10-4 | Exhibition Stadium (26-44) | 46-99 | |
| » W: Mike Flanagan (22-7) L: Phil Huffman (6-15) | Seventh | 49½ out |
| Friday, September 14 |
| » Defeated Indians (74-72), 4-3 | Exhibition Stadium (27-44) | 47-99 | |
| » W: Dave Stieb (7-6) L: Rick Wise (15-8) | Seventh | 49½ out |
| Saturday, September 15 |
| » Defeated Indians (74-73), 5-2 | Exhibition Stadium (28-44) | 48-99 | Won 2 |
| » W: Balor Moore (4-6) L: Len Barker (6-5) | Seventh | 48½ out |
| Sunday, September 16 |
| » Defeated Indians (74-74), 8-2 | Exhibition Stadium (29-44) | 49-99 | Won 3 |
| » W: Tom Underwood (8-16) L: Wayne Garland (4-10) | Seventh | 48½ out |
| Monday, September 17 |
| » Defeated Red Sox (82-65), 5-4 | Exhibition Stadium (30-44) | 50-99 | Won 4 |
| » W: Jesse Jefferson (2-10) L: Dick Drago (9-6) | Seventh | 49 out |
| » Lost to Red Sox (83-65), 5-3 | Exhibition Stadium (30-45) | 50-100 | |
| » W: Chuck Rainey (7-5) L: Dave Freisleben (2-3) S: Bill Campbell (9) | Seventh | 49 out |
| Tuesday, September 18 |
| » Lost to Red Sox (84-65), 8-3 | Exhibition Stadium (30-46) | 50-101 | Lost 2 |
| » W: Mike Torrez (15-12) L: Phil Huffman (6-16) | Seventh | 49 out |
| Wednesday, September 19 |
| » Lost to Red Sox (85-65), 8-0 | Exhibition Stadium (30-47) | 50-102 | Lost 3 |
| » W: Bob Stanley (16-10) L: Dave Stieb (7-7) | Seventh | 49 out |
| Thursday, September 20 |
| » Defeated Red Sox (85-66), 6-2 | Exhibition Stadium (31-47) | 51-102 | |
| » W: Balor Moore (5-6) L: Steve Renko (10-9) | Seventh | 49 out |
| Friday, September 21 |
| » Defeated Yankees (81-71), 3-2 | Exhibition Stadium (32-47) | 52-102 | Won 2 |
| » W: Tom Underwood (9-16) L: Ron Guidry (17-8) S: Tom Buskey (7) | Seventh | 48½ out |
| Saturday, September 22 |
| » Lost to Yankees (82-71), 7-4 | Exhibition Stadium (32-48) | 52-103 | |
| » W: Luis Tiant (12-8) L: Butch Edge (3-3) S: Rich Gossage (16) | Seventh | 48½ out |
| Sunday, September 23 |
| » Lost to Yankees (83-71), 7-5 | Exhibition Stadium (32-49) | 52-104 | Lost 2 |
| » W: Tommy John (20-9) L: Phil Huffman (6-17) S: Rich Gossage (17) | Seventh | 49 out |
| Tuesday, September 25 |
| » Defeated Red Sox (87-68), 5-3 | Fenway Park (1-3) | 53-104 | |
| » W: Dave Stieb (8-7) L: Bob Stanley (16-11) | Seventh | 48 out |
| Wednesday, September 26 |
| » Lost to Red Sox (88-68), 6-4 | Fenway Park (1-4) | 53-105 | |
| » W: Chuck Rainey (8-5) L: Balor Moore (5-7) S: Dick Drago (12) | Seventh | 49 out |
| Thursday, September 27 |
| » Lost to Red Sox (89-68), 6-5 | Fenway Park (1-5) | 53-106 | Lost 2 |
| » W: Dick Drago (10-6) L: Tom Buskey (6-10) | Seventh | 49½ out |
| Friday, September 28 |
| » Lost to Yankees (87-71), 7-3 | Yankee Stadium (2-3) | 53-107 | Lost 3 |
| » W: Luis Tiant (13-8) L: Butch Edge (3-4) | Seventh | 50½ out |
| Saturday, September 29 |
| » Lost to Yankees (88-71), 9-4 | Yankee Stadium (2-4) | 53-108 | Lost 4 |
| » W: Tommy John (21-9) L: Phil Huffman (6-18) | Seventh | 50½ out |
| Sunday, September 30 |
| » Lost to Yankees (89-71), 9-2 | Yankee Stadium (2-5) | 53-109 | Lost 5 |
| » W: Ron Davis (14-2) L: Dave Stieb (8-8) S: Mike Griffin (1) | Seventh | 50½ out |
| Sunday, October 21 |
| Future Blue Jay Gabe Gross is born in Baltimore, MD. |
| Friday, November 9 |
| Future Blue Jay David Bush is born in Pittsburgh, PA. |
Game information provided by Retrosheet (www.retrosheet.org) |