| Friday, January 27 |
| Former White Sox Sarge Connally dies in Temple, TX at the age of 80. |
| Tuesday, March 21 |
| Future White Sox Jeff Bajenaru is born in Pomona, CA. |
| Monday, March 27 |
| Former White Sox Dutch Zwilling dies in LaCrescenta, CA at the age of 90. |
| Wednesday, April 5 |
| » Major-league debuts: Hosken Powell (Twins) |
| Friday, April 7 |
| » Defeated Red Sox (0-1), 6-5 | Comiskey Park I (1-0) | 1-0 | |
| » W: Lerrin LaGrow (1-0) L: Dick Drago (0-1) | First | -- |
| Saturday, April 8 |
| » Defeated Red Sox (0-2), 6-5 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » W: Pablo Torrealba (1-0) L: Bill Campbell (0-1) S: Lerrin LaGrow (1) | First | -- |
| Sunday, April 9 |
| » Lost to Red Sox (1-2), 5-0 | Comiskey Park I (2-1) | 2-1 | |
| » W: Bill Lee (1-0) L: Wilbur Wood (0-1) | First | -- |
| Tuesday, April 11 |
| » Defeated Blue Jays (1-3), 9-5 | Comiskey Park I (3-1) | 3-1 | |
| » W: Ken Kravec (1-0) L: Jesse Jefferson (0-1) S: Pablo Torrealba (1) | First | -- |
| Wednesday, April 12 |
| » Defeated Blue Jays (1-4), 5-4 | Comiskey Park I (4-1) | 4-1 | Won 2 |
| » W: Steve Stone (1-0) L: Dave Lemanczyk (0-2) S: Lerrin LaGrow (2) | First | -- |
| Thursday, April 13 |
| » Lost to Yankees (2-4), 4-2 | Yankee Stadium (0-1) | 4-2 | |
| » W: Ron Guidry (1-0) L: Wilbur Wood (0-2) | Third | 1 out |
| Saturday, April 15 |
| » Lost to Yankees (3-4), 3-2 | Yankee Stadium (0-2) | 4-3 | Lost 2 |
| » W: Ed Figueroa (2-0) L: Francisco Barrios (0-1) | Fourth | 1½ out |
| Sunday, April 16 |
| » Lost to Yankees (4-4), 3-0 | Yankee Stadium (0-3) | 4-4 | Lost 3 |
| » W: Dick Tidrow (1-1) L: Ken Kravec (1-1) S: Sparky Lyle (1) | Third | 2½ out |
| Monday, April 17 |
| » Lost to Tigers (7-2), 10-9 | Tiger Stadium (0-1) | 4-5 | Lost 4 |
| » W: John Hiller (1-0) L: Jim Willoughby (0-1) | Third | 3½ out |
| Friday, April 21 |
| » Defeated Blue Jays (3-9), 11-2 | Exhibition Stadium (1-0) | 5-5 | |
| » W: Francisco Barrios (1-1) L: Tom Underwood (0-2) S: Lerrin LaGrow (3) | Fourth | 3 out |
| Saturday, April 22 |
| » Lost to Blue Jays (4-9), 4-2 | Exhibition Stadium (1-1) | 5-6 | |
| » W: Jim Clancy (1-1) L: Wilbur Wood (0-3) S: Mike Willis (2) | Fourth | 4 out |
| Sunday, April 23 |
| » Lost to Blue Jays (5-9), 4-0 | Exhibition Stadium (1-2) | 5-7 | Lost 2 |
| » W: Jesse Jefferson (1-2) L: Steve Stone (1-1) | Fourth | 5 out |
| Monday, April 24 |
| » Lost to Tigers (10-3), 4-1 | Comiskey Park I (4-2) | 5-8 | Lost 3 |
| » W: Jack Billingham (3-0) L: Ken Kravec (1-2) | Fourth | 6 out |
| Tuesday, April 25 |
| » Lost to Tigers (11-3), 8-4 | Comiskey Park I (4-3) | 5-9 | Lost 4 |
| » W: John Hiller (3-0) L: Pablo Torrealba (1-1) | Fourth | 7 out |
| Wednesday, April 26 |
| » Defeated Tigers (11-4), 7-2 | Comiskey Park I (5-3) | 6-9 | |
| » W: Wilbur Wood (1-3) L: Jim Crawford (1-2) | Fourth | 7 out |
| Future White Sox Joe Crede is born in Jefferson City, MO. |
| Friday, April 28 |
| » Lost to Orioles (6-11), 6-4 | Comiskey Park I (5-4) | 6-10 | |
| » W: Dennis Martinez (2-1) L: Pablo Torrealba (1-2) S: Don Stanhouse (4) | Fifth | 6½ out |
| Saturday, April 29 |
| » Lost to Orioles (7-11), 5-2 | Comiskey Park I (5-5) | 6-11 | Lost 2 |
| » W: Jim Palmer (3-1) L: Ken Kravec (1-3) S: Don Stanhouse (5) | Fifth | 7½ out |
| Sunday, April 30 |
| » Lost to Orioles (8-11), 8-7 | Comiskey Park I (5-6) | 6-12 | Lost 3 |
| » W: Scott McGregor (1-3) L: Pablo Torrealba (1-3) | Fifth | 8½ out |
| Tuesday, May 2 |
| » Defeated Brewers (9-12), 5-3 | County Stadium (1-0) | 7-12 | |
| » W: Wilbur Wood (2-3) L: Lary Sorensen (2-2) | Fifth | 8½ out |
| Wednesday, May 3 |
| » Lost to Brewers (10-12), 4-0 | County Stadium (1-1) | 7-13 | |
| » W: Jerry Augustine (4-3) L: Rich Wortham (0-1) | Fifth | 9½ out |
| » Major-league debuts: Rich Wortham (White Sox) |
| Saturday, May 6 |
| » Lost to Red Sox (15-10), 6-4 | Fenway Park (0-1) | 7-14 | Lost 2 |
| » W: Bob Stanley (2-1) L: Jim Willoughby (0-2) | Seventh | 10½ out |
| » Lost to Red Sox (16-10), 3-0 | Fenway Park (0-2) | 7-15 | Lost 3 |
| » W: Jim Wright (1-0) L: Francisco Barrios (1-2) | Seventh | 10½ out |
| Sunday, May 7 |
| » Lost to Red Sox (17-10), 5-0 | Fenway Park (0-3) | 7-16 | Lost 4 |
| » W: Mike Torrez (4-1) L: Pablo Torrealba (1-4) | Seventh | 10½ out |
| Wednesday, May 10 |
| » Defeated Twins (10-21), 7-2 | Comiskey Park I (6-6) | 8-16 | |
| » W: Rich Wortham (1-1) L: Roger Erickson (2-3) | Fifth | 9 out |
| Friday, May 12 |
| » Defeated Brewers (12-16), 4-3 | Comiskey Park I (7-6) | 9-16 | Won 2 |
| » W: Wilbur Wood (3-3) L: Jerry Augustine (4-5) S: Jim Willoughby (1) | Fifth | 9 out |
| Saturday, May 13 |
| » Lost to Brewers (13-16), 6-1 | Comiskey Park I (7-7) | 9-17 | |
| » W: Andy Replogle (2-0) L: Steve Stone (1-2) | Fifth | 10 out |
| Sunday, May 14 |
| » Lost to Brewers (14-16), 5-4 | Comiskey Park I (7-8) | 9-18 | Lost 2 |
| » W: Mike Caldwell (3-2) L: Francisco Barrios (1-3) | Sixth | 10 out |
| Monday, May 15 |
| » Lost to Yankees (18-12), 4-1 | Comiskey Park I (7-9) | 9-19 | Lost 3 |
| » W: Jim Beattie (2-0) L: Rich Wortham (1-2) S: Sparky Lyle (6) | Seventh | 11 out |
| Tuesday, May 16 |
| » Lost to Yankees (19-12), 8-3 | Comiskey Park I (7-10) | 9-20 | Lost 4 |
| » W: Ken Holtzman (1-0) L: Wilbur Wood (3-4) S: Rich Gossage (4) | Seventh | 11 out |
| Wednesday, May 17 |
| » Defeated Angels (19-14), 9-6 | Comiskey Park I (8-10) | 10-20 | |
| » W: Steve Stone (2-2) L: Nolan Ryan (2-3) | Sixth | 10 out |
| Thursday, May 18 |
| » Lost to Angels (20-14), 9-5 | Comiskey Park I (8-11) | 10-21 | |
| » W: Chris Knapp (5-3) L: Francisco Barrios (1-4) S: Dave LaRoche (6) | Seventh | 10 out |
| Friday, May 19 |
| » Defeated Athletics (22-14), 6-2 | Oakland-Alameda County Stadium (1-0) | 11-21 | |
| » W: Wilbur Wood (4-4) L: Pete Broberg (4-3) | Fifth | 9 out |
| Saturday, May 20 |
| » Lost to Athletics (23-14), 4-3 | Oakland-Alameda County Stadium (1-1) | 11-22 | |
| » W: Rick Langford (1-2) L: Lerrin LaGrow (1-1) | Seventh | 10 out |
| Future White Sox Wilson Valdez is born in Nizao, D.R. |
| Sunday, May 21 |
| » Defeated Athletics (23-15), 6-2 | Oakland-Alameda County Stadium (2-1) | 12-22 | |
| » W: Steve Stone (3-2) L: Bob Lacey (3-2) S: Jim Willoughby (2) | Fifth | 10 out |
| » Lost to Athletics (24-15), 8-0 | Oakland-Alameda County Stadium (2-2) | 12-23 | |
| » W: John Henry Johnson (4-2) L: Francisco Barrios (1-5) | Fifth | 10 out |
| Tuesday, May 23 |
| » Lost to Angels (22-16), 5-4 | Anaheim Stadium (0-1) | 12-24 | Lost 2 |
| » W: Nolan Ryan (3-3) L: Jim Willoughby (0-3) | Seventh | 10 out |
| Wednesday, May 24 |
| » Lost to Angels (23-16), 4-1 | Anaheim Stadium (0-2) | 12-25 | Lost 3 |
| » W: Chris Knapp (6-3) L: Ken Kravec (1-4) | Seventh | 10 out |
| Thursday, May 25 |
| » Lost to Angels (24-16), 6-0 | Anaheim Stadium (0-3) | 12-26 | Lost 4 |
| » W: Frank Tanana (8-1) L: Ron Schueler (0-1) | Seventh | 11 out |
| Friday, May 26 |
| » Lost to Athletics (25-17), 3-1 | Comiskey Park I (8-12) | 12-27 | Lost 5 |
| » W: Alan Wirth (2-3) L: Steve Stone (3-3) S: Bob Lacey (3) | Seventh | 12 out |
| Saturday, May 27 |
| » Lost to Athletics (26-17), 4-3 | Comiskey Park I (8-13) | 12-28 | Lost 6 |
| » W: Bob Lacey (4-2) L: Jim Willoughby (0-4) | Seventh | 12½ out |
| Sunday, May 28 |
| » Defeated Athletics (26-18), 3-2 | Comiskey Park I (9-13) | 13-28 | |
| » W: Ken Kravec (2-4) L: Matt Keough (2-4) S: Jim Willoughby (3) | Seventh | 10½ out |
| » Defeated Athletics (26-19), 4-0 | Comiskey Park I (10-13) | 14-28 | Won 2 |
| » W: Francisco Barrios (2-5) L: Steve Renko (0-1) | Seventh | 10½ out |
| Monday, May 29 |
| » Defeated Angels (25-19), 7-0 | Comiskey Park I (11-13) | 15-28 | Won 3 |
| » W: Pablo Torrealba (2-4) L: Chris Knapp (6-4) | Sixth | 10½ out |
| Former White Sox Carl Reynolds dies in Houston, TX at the age of 76. |
| Tuesday, May 30 |
| » Defeated Angels (25-20), 6-2 | Comiskey Park I (12-13) | 16-28 | Won 4 |
| » W: Wilbur Wood (5-4) L: Frank Tanana (8-2) S: Jim Willoughby (4) | Sixth | 9½ out |
| Wednesday, May 31 |
| » Defeated Angels (25-21), 17-2 | Comiskey Park I (13-13) | 17-28 | Won 5 |
| » W: Steve Stone (4-3) L: Don Aase (2-3) | Sixth | 9 out |
| Friday, June 2 |
| » Defeated Royals (26-20), 5-1 | Royals Stadium (1-0) | 18-28 | Won 6 |
| » W: Francisco Barrios (3-5) L: Andy Hassler (0-2) | Sixth | 8 out |
| Saturday, June 3 |
| » Defeated Royals (26-21), 9-5 | Royals Stadium (2-0) | 19-28 | Won 7 |
| » W: Ken Kravec (3-4) L: Rich Gale (5-1) S: Rich Hinton (1) | Sixth | 8 out |
| Former White Sox Marv Rickert dies in Oakville, WA at the age of 58. |
| Sunday, June 4 |
| » Lost to Royals (27-21), 13-2 | Royals Stadium (2-1) | 19-29 | |
| » W: Paul Splittorff (7-4) L: Wilbur Wood (5-5) | Sixth | 9 out |
| Monday, June 5 |
| » Defeated Indians (23-27), 2-0 | Cleveland Stadium (1-0) | 20-29 | |
| » W: Steve Stone (5-3) L: Rick Waits (3-6) | Sixth | 9 out |
| Tuesday, June 6 |
| » Defeated Indians (23-28), 3-0 | Cleveland Stadium (2-0) | 21-29 | Won 2 |
| » W: Francisco Barrios (4-5) L: Sid Monge (2-1) | Fifth | 9 out |
| Wednesday, June 7 |
| » Defeated Twins (21-31), 8-3 | Metropolitan Stadium (1-0) | 22-29 | Won 3 |
| » W: Ken Kravec (4-4) L: Roger Erickson (6-4) | Fifth | 8½ out |
| Thursday, June 8 |
| » Defeated Twins (21-32), 2-1 | Metropolitan Stadium (2-0) | 23-29 | Won 4 |
| » W: Wilbur Wood (6-5) L: Dave Goltz (2-4) S: Jim Willoughby (5) | Fifth | 7½ out |
| Friday, June 9 |
| » Defeated Rangers (28-25), 4-3 | Arlington Stadium (1-0) | 24-29 | Won 5 |
| » W: Ron Schueler (1-1) L: Doc Medich (1-2) S: Lerrin LaGrow (4) | Fifth | 6½ out |
| Saturday, June 10 |
| » Lost to Rangers (29-25), 4-3 | Arlington Stadium (1-1) | 24-30 | |
| » W: Dock Ellis (5-2) L: Steve Stone (5-4) | Fifth | 6½ out |
| Sunday, June 11 |
| » Defeated Rangers (29-26), 2-1 | Arlington Stadium (2-1) | 25-30 | |
| » W: Francisco Barrios (5-5) L: Reggie Cleveland (1-3) S: Lerrin LaGrow (5) | Fifth | 5½ out |
| Monday, June 12 |
| » Defeated Indians (26-29), 1-0 | Comiskey Park I (14-13) | 26-30 | Won 2 |
| » W: Ken Kravec (5-4) L: Rick Waits (3-7) S: Jim Willoughby (6) | Fifth | 4½ out |
| Tuesday, June 13 |
| » Defeated Indians (26-30), 10-9 | Comiskey Park I (15-13) | 27-30 | Won 3 |
| » W: Rich Hinton (1-0) L: Al Fitzmorris (0-1) S: Lerrin LaGrow (6) | Fifth | 3½ out |
| Wednesday, June 14 |
| » Defeated Rangers (30-28), 4-1 | Comiskey Park I (16-13) | 28-30 | Won 4 |
| » W: Ron Schueler (2-1) L: Jon Matlack (5-7) S: Jim Willoughby (7) | Fifth | 2½ out |
| Thursday, June 15 |
| » Defeated Rangers (30-29), 3-1 | Comiskey Park I (17-13) | 29-30 | Won 5 |
| » W: Steve Stone (6-4) L: Doc Medich (1-3) S: Lerrin LaGrow (7) | Fifth | 2½ out |
| Friday, June 16 |
| » Lost to Royals (32-27), 2-1 | Comiskey Park I (17-14) | 29-31 | |
| » W: Larry Gura (4-1) L: Francisco Barrios (5-6) S: Al Hrabosky (8) | Fifth | 3½ out |
| Saturday, June 17 |
| » Defeated Royals (32-28), 6-1 | Comiskey Park I (18-14) | 30-31 | |
| » W: Ken Kravec (6-4) L: Rich Gale (6-2) S: Jim Willoughby (8) | Fifth | 2½ out |
| Sunday, June 18 |
| » Lost to Royals (33-28), 3-2 | Comiskey Park I (18-15) | 30-32 | |
| » W: Al Hrabosky (2-2) L: Lerrin LaGrow (1-2) | Fourth | 2½ out |
| » Defeated Royals (33-29), 11-0 | Comiskey Park I (19-15) | 31-32 | |
| » W: Ron Schueler (3-1) L: Paul Splittorff (8-6) S: Jim Willoughby (9) | Fourth | 2½ out |
| Monday, June 19 |
| » Lost to Mariners (21-47), 7-4 | Comiskey Park I (19-16) | 31-33 | |
| » W: Mike Parrott (1-0) L: Jack Kucek (0-1) S: Enrique Romo (6) | Fifth | 3½ out |
| Tuesday, June 20 |
| » Lost to Mariners (22-47), 4-2 | Comiskey Park I (19-17) | 31-34 | Lost 2 |
| » W: Paul Mitchell (3-7) L: Steve Stone (6-5) S: Enrique Romo (7) | Fifth | 4½ out |
| Former White Sox Bill Dietrich dies in Philadelphia, PA at the age of 69. |
| Wednesday, June 21 |
| » Major-league debuts: Dave Machemer (Angels) |
| Thursday, June 22 |
| » Lost to Mariners (23-47), 8-6 | Comiskey Park I (19-18) | 31-35 | Lost 3 |
| » W: John Montague (1-3) L: Jim Willoughby (0-5) | Fifth | 4½ out |
| Future White Sox Willie Harris is born in Cairo, GA. |
| Friday, June 23 |
| » Lost to Twins (28-38), 2-1 | Comiskey Park I (19-19) | 31-36 | Lost 4 |
| » W: Dave Goltz (5-4) L: Ken Kravec (6-5) | Fifth | 5 out |
| Saturday, June 24 |
| » Defeated Twins (28-39), 7-4 | Comiskey Park I (20-19) | 32-36 | |
| » W: Wilbur Wood (7-5) L: Darrell Jackson (1-1) S: Lerrin LaGrow (8) | Fifth | 5 out |
| Sunday, June 25 |
| » Lost to Twins (29-39), 8-5 | Comiskey Park I (20-20) | 32-37 | |
| » W: Mike Marshall (2-6) L: Ron Schueler (3-2) | Fifth | 6 out |
| » Lost to Twins (30-39), 9-6 | Comiskey Park I (20-21) | 32-38 | Lost 2 |
| » W: Roger Erickson (8-5) L: Rich Hinton (1-1) S: Mike Marshall (10) | Fifth | 6 out |
| Monday, June 26 |
| » Lost to Mariners (26-48), 8-3 | Kingdome (0-1) | 32-39 | Lost 3 |
| » W: Paul Mitchell (4-7) L: Francisco Barrios (5-7) S: Shane Rawley (4) | Fourth | 6½ out |
| Tuesday, June 27 |
| » Defeated Mariners (26-49), 10-6 | Kingdome (1-1) | 33-39 | |
| » W: Wilbur Wood (8-5) L: Dick Pole (4-9) | Fifth | 6½ out |
| Wednesday, June 28 |
| » Defeated Mariners (26-50), 4-2 | Kingdome (2-1) | 34-39 | Won 2 |
| » W: Ken Kravec (7-5) L: Glenn Abbott (3-5) S: Lerrin LaGrow (9) | Fifth | 5½ out |
| Thursday, June 29 |
| » Lost to Mariners (27-50), 9-7 | Kingdome (2-2) | 34-40 | |
| » W: Enrique Romo (5-2) L: Lerrin LaGrow (1-3) | Fifth | 5½ out |
| Saturday, July 1 |
| » Lost to Twins (31-41), 10-0 | Metropolitan Stadium (2-1) | 34-41 | Lost 2 |
| » Manager: Larry Doby |
| » W: Dave Goltz (6-5) L: Francisco Barrios (5-8) | Fifth | 6 out |
| » Major-league debuts: Steve Trout (White Sox) |
| Sunday, July 2 |
| » Defeated Twins (31-42), 8-5 | Metropolitan Stadium (3-1) | 35-41 | |
| » W: Wilbur Wood (9-5) L: Geoff Zahn (7-6) S: Jim Willoughby (10) | Fifth | 5½ out |
| » Lost to Twins (32-42), 9-5 | Metropolitan Stadium (3-2) | 35-42 | |
| » W: Mike Marshall (3-6) L: Ron Schueler (3-3) | Fifth | 5½ out |
| Monday, July 3 |
| » Defeated Rangers (40-37), 7-6 | Comiskey Park I (21-21) | 36-42 | |
| » W: Jim Willoughby (1-5) L: Reggie Cleveland (2-4) | Fifth | 5½ out |
| Tuesday, July 4 |
| » Defeated Rangers (40-38), 2-1 | Comiskey Park I (22-21) | 37-42 | Won 2 |
| » W: Mike Proly (1-0) L: Fergie Jenkins (8-4) | Fifth | 4½ out |
| Wednesday, July 5 |
| » Lost to Red Sox (54-24), 9-2 | Comiskey Park I (22-22) | 37-43 | |
| » W: Bill Lee (9-3) L: Steve Stone (6-6) S: Bob Stanley (4) | Fifth | 5 out |
| Thursday, July 6 |
| » Lost to Red Sox (55-24), 7-6 | Comiskey Park I (22-23) | 37-44 | Lost 2 |
| » W: Bill Campbell (5-4) L: Jim Willoughby (1-6) | Fifth | 5½ out |
| Friday, July 7 |
| » Lost to Blue Jays (31-52), 3-2 | Comiskey Park I (22-24) | 37-45 | Lost 3 |
| » W: Joe Coleman (4-0) L: Rich Hinton (1-2) S: Victor Cruz (4) | Sixth | 6½ out |
| Saturday, July 8 |
| » Lost to Blue Jays (32-52), 3-0 | Comiskey Park I (22-25) | 37-46 | Lost 4 |
| » W: Jim Clancy (6-7) L: Ken Kravec (7-6) S: Mike Willis (5) | Sixth | 8 out |
| Sunday, July 9 |
| » Defeated Blue Jays (32-53), 5-3 | Comiskey Park I (23-25) | 38-46 | |
| » W: Steve Stone (7-6) L: Tom Underwood (5-8) S: Jim Willoughby (11) | Sixth | 7 out |
| Thursday, July 13 |
| » Defeated Yankees (46-39), 6-1 | Yankee Stadium (1-3) | 39-46 | Won 2 |
| » W: Wilbur Wood (10-5) L: Dick Tidrow (4-7) | Sixth | 7 out |
| Friday, July 14 |
| » Lost to Yankees (47-39), 7-6 | Yankee Stadium (1-4) | 39-47 | |
| » W: Rich Gossage (5-8) L: Rich Hinton (1-3) | Sixth | 8 out |
| Saturday, July 15 |
| » Lost to Brewers (50-36), 3-1 | County Stadium (1-2) | 39-48 | Lost 2 |
| » W: Lary Sorensen (12-5) L: Ron Schueler (3-4) | Sixth | 9 out |
| Future White Sox Miguel Olivo is born in Monte Cristi, D.R. |
| Sunday, July 16 |
| » Lost to Brewers (51-36), 10-1 | County Stadium (1-3) | 39-49 | Lost 3 |
| » W: Bill Travers (6-4) L: Steve Stone (7-7) | Sixth | 9 out |
| Monday, July 17 |
| » Lost to Brewers (52-36), 6-1 | County Stadium (1-4) | 39-50 | Lost 4 |
| » W: Mike Caldwell (11-5) L: Francisco Barrios (5-9) | Sixth | 9 out |
| Tuesday, July 18 |
| » Lost to Brewers (53-36), 7-2 | County Stadium (1-5) | 39-51 | Lost 5 |
| » W: Jerry Augustine (10-9) L: Wilbur Wood (10-6) | Sixth | 9½ out |
| » Major-league debuts: Mike Colbern (White Sox) |
| Wednesday, July 19 |
| » Lost to Orioles (51-42), 10-3 | Comiskey Park I (23-26) | 39-52 | Lost 6 |
| » W: Jim Palmer (11-8) L: Ken Kravec (7-7) | Sixth | 10½ out |
| Friday, July 21 |
| » Lost to Yankees (50-42), 7-4 | Comiskey Park I (23-27) | 39-53 | Lost 7 |
| » W: Sparky Lyle (7-1) L: Rich Hinton (1-4) S: Rich Gossage (13) | Sixth | 12 out |
| Saturday, July 22 |
| » Lost to Yankees (51-42), 7-2 | Comiskey Park I (23-28) | 39-54 | Lost 8 |
| » W: Catfish Hunter (3-3) L: Wilbur Wood (10-7) | Sixth | 13 out |
| Sunday, July 23 |
| » Lost to Yankees (52-42), 3-1 | Comiskey Park I (23-29) | 39-55 | Lost 9 |
| » W: Ed Figueroa (9-7) L: Ken Kravec (7-8) S: Rich Gossage (14) | Sixth | 14 out |
| Monday, July 24 |
| » Defeated Brewers (57-38), 5-1 | Comiskey Park I (24-29) | 40-55 | |
| » W: Steve Stone (8-7) L: Lary Sorensen (12-7) | Sixth | 14 out |
| Tuesday, July 25 |
| » Defeated Brewers (57-39), 4-2 | Comiskey Park I (25-29) | 41-55 | Won 2 |
| » W: Francisco Barrios (6-9) L: Eduardo Rodriguez (2-4) S: Mike Proly (1) | Sixth | 13 out |
| Wednesday, July 26 |
| » Lost to Athletics (51-50), 8-4 | Comiskey Park I (25-30) | 41-56 | |
| » W: John Henry Johnson (8-6) L: Wilbur Wood (10-8) S: Elias Sosa (12) | Sixth | 14 out |
| Thursday, July 27 |
| » Lost to Athletics (52-50), 7-4 | Comiskey Park I (25-31) | 41-57 | Lost 2 |
| » W: Bob Lacey (7-5) L: Ken Kravec (7-9) S: Elias Sosa (13) | Sixth | 15 out |
| Friday, July 28 |
| » Lost to Rangers (49-51), 9-5 | Comiskey Park I (25-32) | 41-58 | Lost 3 |
| » W: Paul Mirabella (1-0) L: Ron Schueler (3-5) | Sixth | 16 out |
| » Major-league debuts: Paul Mirabella (Rangers) |
| Saturday, July 29 |
| » Defeated Rangers (49-52), 6-2 | Comiskey Park I (26-32) | 42-58 | |
| » W: Steve Stone (9-7) L: Fergie Jenkins (9-7) | Sixth | 15 out |
| Sunday, July 30 |
| » Defeated Rangers (49-53), 5-4 | Comiskey Park I (27-32) | 43-58 | Won 2 |
| » W: Lerrin LaGrow (2-3) L: Reggie Cleveland (3-7) | Sixth | 14½ out |
| » Defeated Rangers (49-54), 4-2 | Comiskey Park I (28-32) | 44-58 | Won 3 |
| » W: Francisco Barrios (7-9) L: Doyle Alexander (6-8) S: Jim Willoughby (12) | Sixth | 14½ out |
| Monday, July 31 |
| » Lost to Red Sox (65-38), 9-2 | Fenway Park (0-4) | 44-59 | |
| » W: Dennis Eckersley (12-4) L: Ken Kravec (7-10) | Sixth | 14½ out |
| Tuesday, August 1 |
| » Defeated Red Sox (65-39), 5-2 | Fenway Park (1-4) | 45-59 | |
| » W: Mike Proly (2-0) L: Luis Tiant (7-4) | Fifth | 13½ out |
| Thursday, August 3 |
| » Lost to Tigers (57-49), 5-4 | Tiger Stadium (0-2) | 45-60 | |
| » W: Bob Sykes (6-5) L: Lerrin LaGrow (2-4) | Sixth | 13½ out |
| Friday, August 4 |
| » Lost to Tigers (58-49), 7-1 | Tiger Stadium (0-3) | 45-61 | Lost 2 |
| » W: Kip Young (3-1) L: Wilbur Wood (10-9) | Sixth | 13½ out |
| Saturday, August 5 |
| » Lost to Tigers (59-49), 7-0 | Tiger Stadium (0-4) | 45-62 | Lost 3 |
| » W: Jack Billingham (11-5) L: Britt Burns (0-1) | Sixth | 14½ out |
| » Major-league debuts: Britt Burns (White Sox) |
| Sunday, August 6 |
| » Lost to Tigers (60-49), 8-0 | Tiger Stadium (0-5) | 45-63 | Lost 4 |
| » W: Jim Slaton (12-8) L: Ken Kravec (7-11) | Sixth | 15½ out |
| Monday, August 7 |
| » Defeated Royals (60-48), 5-3 | Royals Stadium (3-1) | 46-63 | |
| » W: Lerrin LaGrow (3-4) L: Dennis Leonard (12-14) | Fifth | 14½ out |
| Tuesday, August 8 |
| » Lost to Royals (61-48), 10-4 | Royals Stadium (3-2) | 46-64 | |
| » W: Paul Splittorff (13-9) L: Mike Proly (2-1) S: Marty Pattin (3) | Sixth | 15½ out |
| Wednesday, August 9 |
| » Lost to Blue Jays (43-69), 8-0 | Exhibition Stadium (1-3) | 46-65 | Lost 2 |
| » W: Jesse Jefferson (7-9) L: Steve Stone (9-8) | Sixth | 16½ out |
| Thursday, August 10 |
| » Lost to Blue Jays (44-69), 7-3 | Exhibition Stadium (1-4) | 46-66 | Lost 3 |
| » W: Jerry Garvin (3-11) L: Wilbur Wood (10-10) S: Victor Cruz (8) | Sixth | 16½ out |
| Friday, August 11 |
| » Lost to Tigers (62-50), 7-3 | Comiskey Park I (28-33) | 46-67 | Lost 4 |
| » W: Jack Billingham (12-5) L: Britt Burns (0-2) | Sixth | 17½ out |
| Saturday, August 12 |
| » Defeated Tigers (62-51), 6-3 | Comiskey Park I (29-33) | 47-67 | |
| » W: Ken Kravec (8-11) L: Jim Slaton (12-9) S: Lerrin LaGrow (10) | Sixth | 16½ out |
| Sunday, August 13 |
| » Lost to Tigers (63-51), 10-2 | Comiskey Park I (29-34) | 47-68 | |
| » W: Dave Rozema (6-6) L: Mike Proly (2-2) | Sixth | 16½ out |
| Monday, August 14 |
| » Lost to Rangers (58-57), 4-3 | Arlington Stadium (2-2) | 47-69 | Lost 2 |
| » W: Fergie Jenkins (11-7) L: Francisco Barrios (7-10) | Sixth | 16½ out |
| Tuesday, August 15 |
| » Lost to Rangers (59-57), 1-0 | Arlington Stadium (2-3) | 47-70 | Lost 3 |
| » W: Jon Matlack (11-9) L: Steve Stone (9-9) | Sixth | 17½ out |
| Wednesday, August 16 |
| » Defeated Rangers (59-58), 6-2 | Arlington Stadium (3-3) | 48-70 | |
| » W: Ross Baumgarten (1-0) L: Doyle Alexander (7-9) S: Lerrin LaGrow (11) | Sixth | 17 out |
| » Major-league debuts: Ross Baumgarten (White Sox) |
| Thursday, August 17 |
| » Defeated Rangers (59-59), 4-2 | Arlington Stadium (4-3) | 49-70 | Won 2 |
| » W: Ken Kravec (9-11) L: Paul Mirabella (2-1) S: Lerrin LaGrow (12) | Sixth | 16 out |
| Friday, August 18 |
| » Defeated Indians (53-67), 7-1 | Cleveland Stadium (3-0) | 50-70 | Won 3 |
| » W: Mike Proly (3-2) L: Rick Wise (9-16) | Sixth | 15 out |
| Saturday, August 19 |
| » Defeated Indians (53-68), 2-1 | Cleveland Stadium (4-0) | 51-70 | Won 4 |
| » W: Francisco Barrios (8-10) L: Mike Paxton (9-7) | Sixth | 15 out |
| Sunday, August 20 |
| » Lost to Indians (54-68), 10-1 | Cleveland Stadium (4-1) | 51-71 | |
| » W: Rick Waits (8-13) L: Steve Stone (9-10) | Sixth | 16 out |
| Tuesday, August 22 |
| » Lost to Royals (68-55), 6-3 | Comiskey Park I (29-35) | 51-72 | Lost 2 |
| » W: Larry Gura (11-3) L: Ross Baumgarten (1-1) S: Al Hrabosky (16) | Sixth | 17 out |
| Wednesday, August 23 |
| » Defeated Royals (68-56), 3-0 | Comiskey Park I (30-35) | 52-72 | |
| » W: Ken Kravec (10-11) L: Dennis Leonard (14-15) | Sixth | 16 out |
| Thursday, August 24 |
| » Defeated Royals (68-57), 4-1 | Comiskey Park I (31-35) | 53-72 | Won 2 |
| » W: Mike Proly (4-2) L: Paul Splittorff (15-11) S: Lerrin LaGrow (13) | Sixth | 15½ out |
| Friday, August 25 |
| » Lost to Indians (56-71), 2-1 | Comiskey Park I (31-36) | 53-73 | |
| » W: Rick Waits (9-13) L: Francisco Barrios (8-11) S: Jim Kern (11) | Sixth | 15½ out |
| Saturday, August 26 |
| » Defeated Indians (56-72), 8-7 | Comiskey Park I (32-36) | 54-73 | |
| » W: Steve Stone (10-10) L: David Clyde (5-9) S: Jim Willoughby (13) | Sixth | 14½ out |
| Sunday, August 27 |
| » Defeated Indians (56-73), 6-0 | Comiskey Park I (33-36) | 55-73 | Won 2 |
| » W: Ross Baumgarten (2-1) L: Paul Reuschel (4-1) | Sixth | 14 out |
| Monday, August 28 |
| » Lost to Royals (70-59), 3-2 | Royals Stadium (3-3) | 55-74 | |
| » W: Al Hrabosky (6-6) L: Ken Kravec (10-12) | Sixth | 15 out |
| Tuesday, August 29 |
| » Defeated Royals (70-60), 9-3 | Royals Stadium (4-3) | 56-74 | |
| » W: Mike Proly (5-2) L: Rich Gale (13-7) S: Lerrin LaGrow (14) | Sixth | 14 out |
| Wednesday, August 30 |
| » Lost to Royals (71-60), 12-0 | Royals Stadium (4-4) | 56-75 | |
| » W: Larry Gura (12-4) L: Francisco Barrios (8-12) | Sixth | 15 out |
| Friday, September 1 |
| » Lost to Orioles (73-60), 3-0 | Memorial Stadium (0-1) | 56-76 | Lost 2 |
| » W: Jim Palmer (17-12) L: Steve Stone (10-11) S: Don Stanhouse (19) | Sixth | 15½ out |
| » Lost to Orioles (74-60), 9-3 | Memorial Stadium (0-2) | 56-77 | Lost 3 |
| » W: Sammy Stewart (1-0) L: Ross Baumgarten (2-2) S: Joe Kerrigan (3) | Sixth | 15½ out |
| » Major-league debuts: Sammy Stewart (Orioles) |
| Saturday, September 2 |
| » Lost to Orioles (75-60), 9-4 | Memorial Stadium (0-3) | 56-78 | Lost 4 |
| » W: Dennis Martinez (12-10) L: Ken Kravec (10-13) | Sixth | 17 out |
| » Lost to Orioles (76-60), 1-0 | Memorial Stadium (0-4) | 56-79 | Lost 5 |
| » W: Dave Ford (1-0) L: Jack Kucek (0-2) S: Tippy Martinez (5) | Sixth | 17 out |
| » Major-league debuts: Dave Ford (Orioles) |
| Sunday, September 3 |
| » Defeated Orioles (76-61), 4-2 | Memorial Stadium (1-4) | 57-79 | |
| » W: Lerrin LaGrow (4-4) L: Mike Flanagan (17-12) | Sixth | 17 out |
| Monday, September 4 |
| » Lost to Twins (62-76), 2-1 | Metropolitan Stadium (3-3) | 57-80 | |
| » W: Geoff Zahn (11-13) L: Francisco Barrios (8-13) | Sixth | 18 out |
| Tuesday, September 5 |
| » Defeated Twins (62-77), 4-3 | Metropolitan Stadium (4-3) | 58-80 | |
| » W: Steve Trout (1-0) L: Roger Erickson (13-10) S: Lerrin LaGrow (15) | Sixth | 18 out |
| Wednesday, September 6 |
| » Defeated Twins (62-78), 1-0 | Metropolitan Stadium (5-3) | 59-80 | Won 2 |
| » W: Ken Kravec (11-13) L: Dave Goltz (11-10) | Sixth | 18 out |
| Thursday, September 7 |
| » Lost to Mariners (52-85), 5-3 | Comiskey Park I (33-37) | 59-81 | |
| » W: Paul Mitchell (8-13) L: Steve Stone (10-12) | Sixth | 18½ out |
| » Major-league debuts: Harry Chappas (White Sox) |
| Friday, September 8 |
| » Defeated Mariners (52-86), 3-2 | Comiskey Park I (34-37) | 60-81 | |
| » W: Rich Wortham (2-2) L: Jim Colborn (4-11) | Sixth | 18½ out |
| Saturday, September 9 |
| » Lost to Mariners (53-86), 9-6 | Comiskey Park I (34-38) | 60-82 | |
| » W: Enrique Romo (11-6) L: Lerrin LaGrow (4-5) | Sixth | 18 out |
| Sunday, September 10 |
| » Defeated Mariners (53-87), 2-1 | Comiskey Park I (35-38) | 61-82 | |
| » W: Jack Kucek (1-2) L: Glenn Abbott (7-11) | Sixth | 17 out |
| Monday, September 11 |
| » Lost to Twins (64-80), 3-1 | Comiskey Park I (35-39) | 61-83 | |
| » W: Geoff Zahn (12-13) L: Ken Kravec (11-14) S: Mike Marshall (19) | Sixth | 18 out |
| » Major-league debuts: Dave Edwards (Twins) |
| Tuesday, September 12 |
| » Defeated Twins (64-81), 6-1 | Comiskey Park I (36-39) | 62-83 | |
| » W: Rich Hinton (2-4) L: Gary Serum (8-8) | Sixth | 18 out |
| Thursday, September 14 |
| » Defeated Mariners (54-89), 6-5 | Kingdome (3-2) | 63-83 | Won 2 |
| » W: Steve Stone (11-12) L: Rick Honeycutt (5-9) | Sixth | 18½ out |
| » Major-league debuts: Tom Brown (Mariners) |
| Friday, September 15 |
| » Defeated Mariners (54-90), 8-3 | Kingdome (4-2) | 64-83 | Won 3 |
| » W: Rich Wortham (3-2) L: Enrique Romo (11-7) | Sixth | 18½ out |
| Saturday, September 16 |
| » Defeated Mariners (54-91), 9-1 | Kingdome (5-2) | 65-83 | Won 4 |
| » W: Francisco Barrios (9-13) L: Glenn Abbott (7-12) | Sixth | 17½ out |
| Sunday, September 17 |
| » Lost to Mariners (55-91), 3-1 | Kingdome (5-3) | 65-84 | |
| » W: Byron McLaughlin (3-7) L: Jack Kucek (1-3) | Sixth | 18½ out |
| Monday, September 18 |
| » Lost to Athletics (68-84), 6-3 | Oakland-Alameda County Stadium (2-3) | 65-85 | Lost 2 |
| » W: John Henry Johnson (11-8) L: Ken Kravec (11-15) | Sixth | 19½ out |
| Tuesday, September 19 |
| » Defeated Athletics (68-85), 8-4 | Oakland-Alameda County Stadium (3-3) | 66-85 | |
| » W: Steve Stone (12-12) L: Alan Wirth (4-5) | Sixth | 19 out |
| » Defeated Athletics (68-86), 7-3 | Oakland-Alameda County Stadium (4-3) | 67-85 | Won 2 |
| » W: Steve Trout (2-0) L: Steve Renko (6-12) | Sixth | 19 out |
| Friday, September 22 |
| » Lost to Angels (82-72), 3-2 | Comiskey Park I (36-40) | 67-86 | |
| » W: Frank Tanana (18-11) L: Rich Hinton (2-5) S: Dave LaRoche (24) | Sixth | 19½ out |
| Saturday, September 23 |
| » Defeated Angels (82-73), 5-4 | Comiskey Park I (37-40) | 68-86 | |
| » W: Lerrin LaGrow (5-5) L: Dyar Miller (6-2) | Fifth | 19½ out |
| Sunday, September 24 |
| » Lost to Angels (83-73), 7-3 | Comiskey Park I (37-41) | 68-87 | |
| » W: Nolan Ryan (9-13) L: Francisco Barrios (9-14) | Fifth | 19½ out |
| Monday, September 25 |
| » Defeated Athletics (68-90), 6-2 | Comiskey Park I (38-41) | 69-87 | |
| » W: Jack Kucek (2-3) L: John Henry Johnson (11-9) S: Lerrin LaGrow (16) | Fifth | 19½ out |
| Tuesday, September 26 |
| » Lost to Athletics (69-90), 10-3 | Comiskey Park I (38-42) | 69-88 | |
| » W: Alan Wirth (5-5) L: Ken Kravec (11-16) | Fifth | 20½ out |
| Wednesday, September 27 |
| Future White Sox Jon Rauch is born in Louisville, KY. |
| Thursday, September 28 |
| » Lost to Angels (86-73), 11-7 | Anaheim Stadium (0-4) | 69-89 | Lost 2 |
| » W: Ken Brett (3-5) L: Rich Hinton (2-6) S: Dyar Miller (1) | Fifth | 20½ out |
| Friday, September 29 |
| » Defeated Angels (86-74), 9-6 | Anaheim Stadium (1-4) | 70-89 | |
| » W: Steve Trout (3-0) L: Frank Tanana (18-12) S: Jack Kucek (1) | Fifth | 20½ out |
| Saturday, September 30 |
| » Defeated Angels (86-75), 6-5 | Anaheim Stadium (2-4) | 71-89 | Won 2 |
| » W: Lerrin LaGrow (6-5) L: Dave LaRoche (10-9) | Fourth | 19½ out |
| Sunday, October 1 |
| » Lost to Angels (87-75), 5-4 | Anaheim Stadium (2-5) | 71-90 | |
| » W: Nolan Ryan (10-13) L: Francisco Barrios (9-15) | Fourth | 20½ out |
| Thursday, November 23 |
| Former White Sox Buck Ross dies in Charlotte, NC at the age of 64. |
| Saturday, November 25 |
| Future White Sox Joe Borchard is born in Panorama City, CA. |
| Tuesday, December 5 |
| Future White Sox Josh Stewart is born in Paducah, KY. |
Game information provided by Retrosheet (www.retrosheet.org) |