| Tuesday, March 21 |
| Future Twin Cristian Guzman is born in Santo Domingo, D.R. |
| Wednesday, April 5 |
| » Lost to Mariners (1-0), 3-2 | Kingdome (0-1) | 0-1 | |
| » W: Glenn Abbott (1-0) L: Dave Goltz (0-1) S: Enrique Romo (1) | Third | 1 out |
| » Major-league debuts: Hosken Powell (Twins) |
| Thursday, April 6 |
| » Defeated Mariners (1-1), 5-4 | Kingdome (1-1) | 1-1 | |
| » W: Roger Erickson (1-0) L: Dick Pole (0-1) S: Tom Johnson (1) | Second | 1 out |
| » Major-league debuts: Shane Rawley (Mariners) Roger Erickson (Twins) |
| Friday, April 7 |
| » Lost to Mariners (2-1), 6-3 | Kingdome (1-2) | 1-2 | |
| » W: Rick Honeycutt (1-0) L: Pete Redfern (0-1) S: Enrique Romo (2) | Fourth | 1 out |
| Saturday, April 8 |
| » Defeated Mariners (2-2), 8-2 | Kingdome (2-2) | 2-2 | |
| » W: Paul Thormodsgard (1-0) L: Paul Mitchell (0-1) | Fourth | 1 out |
| Sunday, April 9 |
| » Defeated Mariners (2-3), 8-6 | Kingdome (3-2) | 3-2 | Won 2 |
| » W: Gary Serum (1-0) L: Tom House (0-1) | Second | 1 out |
| Monday, April 10 |
| » Lost to Angels (3-1), 3-0 | Anaheim Stadium (0-1) | 3-3 | |
| » W: Ken Brett (1-0) L: Dave Goltz (0-2) | Fourth | 1 out |
| Tuesday, April 11 |
| » Defeated Angels (3-2), 8-1 | Anaheim Stadium (1-1) | 4-3 | |
| » W: Roger Erickson (2-0) L: Don Aase (0-1) | Fourth | 1½ out |
| Wednesday, April 12 |
| » Lost to Angels (4-2), 9-5 | Anaheim Stadium (1-2) | 4-4 | |
| » W: Frank Tanana (2-0) L: Pete Redfern (0-2) S: Dave LaRoche (2) | Fourth | 1½ out |
| Thursday, April 13 |
| » Lost to Angels (5-2), 1-0 | Anaheim Stadium (1-3) | 4-5 | Lost 2 |
| » W: Dave LaRoche (1-0) L: Tom Johnson (0-1) | Fourth | 2½ out |
| Friday, April 14 |
| » Defeated Mariners (2-8), 14-5 | Metropolitan Stadium (1-0) | 5-5 | |
| » W: Geoff Zahn (1-0) L: Tom House (0-2) | Fifth | 2½ out |
| Saturday, April 15 |
| » Defeated Mariners (2-9), 6-5 | Metropolitan Stadium (2-0) | 6-5 | Won 2 |
| » W: Tom Johnson (1-1) L: John Montague (0-1) | Fifth | 2½ out |
| Sunday, April 16 |
| » Lost to Mariners (3-9), 8-5 | Metropolitan Stadium (2-1) | 6-6 | |
| » W: Dick Pole (1-2) L: Roger Erickson (2-1) S: Shane Rawley (1) | Fourth | 3 out |
| » Lost to Mariners (4-9), 7-2 | Metropolitan Stadium (2-2) | 6-7 | Lost 2 |
| » W: Tom House (1-2) L: Dave Johnson (0-1) | Fourth | 3 out |
| Monday, April 17 |
| » Lost to Athletics (7-3), 7-2 | Metropolitan Stadium (2-3) | 6-8 | Lost 3 |
| » W: Pete Broberg (2-0) L: Paul Thormodsgard (1-1) | Fourth | 4 out |
| Wednesday, April 19 |
| » Lost to Athletics (8-3), 6-5 | Metropolitan Stadium (2-4) | 6-9 | Lost 4 |
| » W: Elias Sosa (1-0) L: Tom Johnson (1-2) | Fifth | 5 out |
| Friday, April 21 |
| » Lost to Angels (9-4), 3-2 | Metropolitan Stadium (2-5) | 6-10 | Lost 5 |
| » W: Don Aase (1-1) L: Dave Goltz (0-3) S: Dave LaRoche (3) | Fifth | 5 out |
| Saturday, April 22 |
| » Lost to Angels (10-4), 5-3 | Metropolitan Stadium (2-6) | 6-11 | Lost 6 |
| » W: Frank Tanana (4-0) L: Roger Erickson (2-2) S: Paul Hartzell (3) | Fifth | 6 out |
| Tuesday, April 25 |
| » Lost to Athletics (12-3), 5-3 | Oakland-Alameda County Stadium (0-1) | 6-12 | Lost 7 |
| » W: Elias Sosa (2-0) L: Greg Thayer (0-1) | Fifth | 8½ out |
| » Lost to Athletics (13-3), 4-3 | Oakland-Alameda County Stadium (0-2) | 6-13 | Lost 8 |
| » W: Joe Coleman (1-0) L: Tom Johnson (1-3) | Fifth | 8½ out |
| Wednesday, April 26 |
| » Lost to Athletics (14-3), 9-8 | Oakland-Alameda County Stadium (0-3) | 6-14 | Lost 9 |
| » W: Joe Coleman (2-0) L: Tom Johnson (1-4) | Seventh | 9½ out |
| Thursday, April 27 |
| » Defeated Athletics (14-4), 6-1 | Oakland-Alameda County Stadium (1-3) | 7-14 | |
| » W: Gary Serum (2-0) L: Alan Wirth (1-2) | Sixth | 8½ out |
| Friday, April 28 |
| » Lost to Yankees (9-8), 3-1 | Metropolitan Stadium (2-7) | 7-15 | |
| » W: Ed Figueroa (3-1) L: Paul Thormodsgard (1-2) | Sixth | 8½ out |
| Saturday, April 29 |
| » Defeated Yankees (9-9), 3-1 | Metropolitan Stadium (3-7) | 8-15 | |
| » W: Geoff Zahn (2-0) L: Dick Tidrow (1-2) | Sixth | 8½ out |
| Sunday, April 30 |
| » Lost to Yankees (10-9), 3-2 | Metropolitan Stadium (3-8) | 8-16 | |
| » W: Rich Gossage (1-3) L: Mac Scarce (0-1) | Sixth | 9½ out |
| » Major-league debuts: Brian Doyle (Yankees) |
| Wednesday, May 3 |
| » Lost to Red Sox (13-10), 11-9 | Fenway Park (0-1) | 8-17 | Lost 2 |
| » W: Tom Burgmeier (1-0) L: Dave Johnson (0-2) S: Bob Stanley (2) | Sixth | 11 out |
| Thursday, May 4 |
| » Lost to Red Sox (14-10), 8-1 | Fenway Park (0-2) | 8-18 | Lost 3 |
| » W: Dennis Eckersley (1-1) L: Paul Thormodsgard (1-3) | Sixth | 11½ out |
| Friday, May 5 |
| » Lost to Orioles (10-13), 2-1 | Memorial Stadium (0-1) | 8-19 | Lost 4 |
| » W: Mike Flanagan (2-3) L: Geoff Zahn (2-1) | Seventh | 12½ out |
| Saturday, May 6 |
| » Defeated Orioles (10-14), 8-7 | Memorial Stadium (1-1) | 9-19 | |
| » W: Greg Thayer (1-1) L: Don Stanhouse (0-2) S: Tom Johnson (2) | Sixth | 11½ out |
| Sunday, May 7 |
| » Defeated Orioles (10-15), 15-9 | Memorial Stadium (2-1) | 10-19 | Won 2 |
| » W: Mac Scarce (1-1) L: Jim Palmer (3-2) | Sixth | 10½ out |
| Tuesday, May 9 |
| » Lost to Yankees (16-10), 3-1 | Yankee Stadium (0-1) | 10-20 | |
| » W: Catfish Hunter (2-3) L: Paul Thormodsgard (1-4) S: Sparky Lyle (5) | Sixth | 10½ out |
| Wednesday, May 10 |
| » Lost to White Sox (8-16), 7-2 | Comiskey Park I (0-1) | 10-21 | Lost 2 |
| » W: Rich Wortham (1-1) L: Roger Erickson (2-3) | Seventh | 10½ out |
| Saturday, May 13 |
| » Lost to Red Sox (21-11), 4-2 | Metropolitan Stadium (3-9) | 10-22 | Lost 3 |
| » W: Mike Torrez (5-1) L: Geoff Zahn (2-2) S: Tom Burgmeier (2) | Seventh | 12 out |
| Sunday, May 14 |
| » Lost to Red Sox (22-11), 6-2 | Metropolitan Stadium (3-10) | 10-23 | Lost 4 |
| » W: Dennis Eckersley (3-1) L: Paul Thormodsgard (1-5) S: Tom Burgmeier (3) | Seventh | 12 out |
| Monday, May 15 |
| » Defeated Orioles (13-18), 9-6 | Metropolitan Stadium (4-10) | 11-23 | |
| » W: Mike Marshall (1-0) L: John Flinn (1-1) | Sixth | 12 out |
| Tuesday, May 16 |
| » Defeated Orioles (13-19), 8-1 | Metropolitan Stadium (5-10) | 12-23 | Won 2 |
| » W: Dave Goltz (1-3) L: Jim Palmer (3-4) S: Tom Johnson (3) | Fifth | 11 out |
| Thursday, May 18 |
| » Defeated Royals (18-15), 8-6 | Royals Stadium (1-0) | 13-23 | Won 3 |
| » W: Geoff Zahn (3-2) L: Dennis Leonard (3-7) S: Mike Marshall (1) | Fifth | 9½ out |
| Friday, May 19 |
| » Defeated Royals (18-16), 5-3 | Royals Stadium (2-0) | 14-23 | Won 4 |
| » W: Roger Erickson (3-3) L: Marty Pattin (1-1) S: Mike Marshall (2) | Fourth | 8½ out |
| Saturday, May 20 |
| » Lost to Royals (19-16), 6-3 | Royals Stadium (2-1) | 14-24 | |
| » W: Rich Gale (4-0) L: Paul Thormodsgard (1-6) S: Al Hrabosky (5) | Fifth | 9½ out |
| Sunday, May 21 |
| » Defeated Royals (19-17), 3-2 | Royals Stadium (3-1) | 15-24 | |
| » W: Gary Serum (3-0) L: Paul Splittorff (4-4) S: Mike Marshall (3) | Fourth | 9 out |
| Monday, May 22 |
| » Defeated Rangers (19-18), 2-0 | Metropolitan Stadium (6-10) | 16-24 | Won 2 |
| » W: Geoff Zahn (4-2) L: Jon Matlack (4-5) S: Mike Marshall (4) | Fourth | 8½ out |
| Tuesday, May 23 |
| » Defeated Rangers (19-19), 5-2 | Metropolitan Stadium (7-10) | 17-24 | Won 3 |
| » W: Roger Erickson (4-3) L: Jim Umbarger (2-3) | Fifth | 7½ out |
| Wednesday, May 24 |
| » Lost to Rangers (20-19), 3-2 | Metropolitan Stadium (7-11) | 17-25 | |
| » W: Paul Lindblad (1-0) L: Mike Marshall (1-1) S: Doc Medich (1) | Fifth | 7½ out |
| Thursday, May 25 |
| » Lost to Rangers (21-19), 7-1 | Metropolitan Stadium (7-12) | 17-26 | Lost 2 |
| » W: Fergie Jenkins (5-2) L: Gary Serum (3-1) | Fifth | 8½ out |
| Sunday, May 28 |
| » Lost to Royals (23-19), 8-7 | Metropolitan Stadium (7-13) | 17-27 | Lost 3 |
| » W: Larry Gura (3-1) L: Mike Marshall (1-2) | Fifth | 8½ out |
| Monday, May 29 |
| » Lost to Rangers (23-20), 7-1 | Arlington Stadium (0-1) | 17-28 | Lost 4 |
| » W: Dock Ellis (3-2) L: Gary Serum (3-2) | Fifth | 9 out |
| » Defeated Rangers (23-21), 7-2 | Arlington Stadium (1-1) | 18-28 | |
| » W: Roger Erickson (5-3) L: Jim Umbarger (2-4) S: Mike Marshall (5) | Fifth | 9 out |
| Tuesday, May 30 |
| » Defeated Rangers (23-22), 2-0 | Arlington Stadium (2-1) | 19-28 | Won 2 |
| » W: Geoff Zahn (5-2) L: Fergie Jenkins (5-3) S: Mike Marshall (6) | Fifth | 8 out |
| Thursday, June 1 |
| » Lost to Rangers (24-22), 10-7 | Arlington Stadium (2-2) | 19-29 | |
| » W: Steve Comer (1-1) L: Mike Marshall (1-3) | Fifth | 8½ out |
| Friday, June 2 |
| » Defeated Tigers (27-21), 4-2 | Tiger Stadium (1-0) | 20-29 | |
| » W: Roger Erickson (6-3) L: Jack Billingham (4-3) S: Mike Marshall (7) | Fifth | 7½ out |
| Saturday, June 3 |
| » Defeated Tigers (27-22), 9-2 | Tiger Stadium (2-0) | 21-29 | Won 2 |
| » W: Dave Goltz (2-3) L: Bob Sykes (3-3) | Fifth | 7½ out |
| Sunday, June 4 |
| » Lost to Tigers (28-22), 6-4 | Tiger Stadium (2-1) | 21-30 | |
| » W: Jack Morris (1-1) L: Geoff Zahn (5-3) | Fifth | 8½ out |
| Wednesday, June 7 |
| » Lost to White Sox (22-29), 8-3 | Metropolitan Stadium (7-14) | 21-31 | Lost 2 |
| » W: Ken Kravec (4-4) L: Roger Erickson (6-4) | Sixth | 10 out |
| Thursday, June 8 |
| » Lost to White Sox (23-29), 2-1 | Metropolitan Stadium (7-15) | 21-32 | Lost 3 |
| » W: Wilbur Wood (6-5) L: Dave Goltz (2-4) S: Jim Willoughby (5) | Sixth | 10 out |
| Friday, June 9 |
| » Lost to Indians (24-28), 7-3 | Cleveland Stadium (0-1) | 21-33 | Lost 4 |
| » W: David Clyde (4-0) L: Geoff Zahn (5-4) S: Jim Kern (4) | Sixth | 10 out |
| Saturday, June 10 |
| » Lost to Indians (25-28), 4-3 | Cleveland Stadium (0-2) | 21-34 | Lost 5 |
| » W: Rick Wise (4-9) L: Mike Marshall (1-4) S: Jim Kern (5) | Sixth | 10 out |
| Sunday, June 11 |
| » Lost to Indians (26-28), 2-1 | Cleveland Stadium (0-3) | 21-35 | Lost 6 |
| » W: Mike Paxton (3-3) L: Mike Marshall (1-5) | Sixth | 10 out |
| Tuesday, June 13 |
| » Defeated Blue Jays (19-37), 2-0 | Exhibition Stadium (1-0) | 22-35 | |
| » W: Dave Goltz (3-4) L: Balor Moore (2-1) S: Mike Marshall (8) | Sixth | 8 out |
| » Defeated Blue Jays (19-38), 7-2 | Exhibition Stadium (2-0) | 23-35 | Won 2 |
| » W: Geoff Zahn (6-4) L: Jim Clancy (4-5) | Sixth | 8 out |
| Wednesday, June 14 |
| » Defeated Indians (26-31), 8-2 | Metropolitan Stadium (8-15) | 24-35 | Won 3 |
| » W: Roger Erickson (7-4) L: David Clyde (4-1) | Sixth | 7 out |
| Friday, June 16 |
| » Defeated Tigers (31-29), 5-2 | Metropolitan Stadium (9-15) | 25-35 | Won 4 |
| » W: Darrell Jackson (1-0) L: Dave Rozema (2-3) | Sixth | 7½ out |
| » Major-league debuts: Darrell Jackson (Twins) |
| Saturday, June 17 |
| » Defeated Tigers (31-30), 3-1 | Metropolitan Stadium (10-15) | 26-35 | Won 5 |
| » W: Geoff Zahn (7-4) L: Milt Wilcox (4-5) | Sixth | 6½ out |
| Sunday, June 18 |
| » Defeated Tigers (31-31), 8-4 | Metropolitan Stadium (11-15) | 27-35 | Won 6 |
| » W: Dave Goltz (4-4) L: Jim Slaton (6-4) S: Mike Marshall (9) | Sixth | 6 out |
| Tuesday, June 20 |
| » Lost to Angels (34-31), 10-5 | Metropolitan Stadium (11-16) | 27-36 | |
| » W: Frank Tanana (11-3) L: Roger Erickson (7-5) | Sixth | 7½ out |
| Wednesday, June 21 |
| » Lost to Angels (35-31), 5-2 | Metropolitan Stadium (11-17) | 27-37 | Lost 2 |
| » W: Don Aase (4-3) L: Geoff Zahn (7-5) | Sixth | 7½ out |
| » Major-league debuts: Dave Machemer (Angels) |
| Thursday, June 22 |
| » Lost to Angels (36-31), 4-2 | Metropolitan Stadium (11-18) | 27-38 | Lost 3 |
| » W: Dave LaRoche (6-3) L: Mike Marshall (1-6) | Sixth | 8 out |
| Friday, June 23 |
| » Defeated White Sox (31-36), 2-1 | Comiskey Park I (1-1) | 28-38 | |
| » W: Dave Goltz (5-4) L: Ken Kravec (6-5) | Sixth | 7½ out |
| Saturday, June 24 |
| » Lost to White Sox (32-36), 7-4 | Comiskey Park I (1-2) | 28-39 | |
| » W: Wilbur Wood (7-5) L: Darrell Jackson (1-1) S: Lerrin LaGrow (8) | Sixth | 8½ out |
| Sunday, June 25 |
| » Defeated White Sox (32-37), 8-5 | Comiskey Park I (2-2) | 29-39 | |
| » W: Mike Marshall (2-6) L: Ron Schueler (3-2) | Sixth | 7½ out |
| » Defeated White Sox (32-38), 9-6 | Comiskey Park I (3-2) | 30-39 | Won 2 |
| » W: Roger Erickson (8-5) L: Rich Hinton (1-1) S: Mike Marshall (10) | Sixth | 7½ out |
| Monday, June 26 |
| » Lost to Brewers (40-31), 8-2 | County Stadium (0-1) | 30-40 | |
| » W: Lary Sorensen (10-4) L: Gary Serum (3-3) | Fifth | 8 out |
| Tuesday, June 27 |
| » Lost to Brewers (41-31), 13-6 | County Stadium (0-2) | 30-41 | Lost 2 |
| » W: Andy Replogle (4-1) L: Dave Goltz (5-5) | Sixth | 9 out |
| Saturday, July 1 |
| » Defeated White Sox (34-41), 10-0 | Metropolitan Stadium (12-18) | 31-41 | |
| » W: Dave Goltz (6-5) L: Francisco Barrios (5-8) | Sixth | 7½ out |
| » Major-league debuts: Steve Trout (White Sox) |
| Sunday, July 2 |
| » Lost to White Sox (35-41), 8-5 | Metropolitan Stadium (12-19) | 31-42 | |
| » W: Wilbur Wood (9-5) L: Geoff Zahn (7-6) S: Jim Willoughby (10) | Sixth | 7 out |
| » Defeated White Sox (35-42), 9-5 | Metropolitan Stadium (13-19) | 32-42 | |
| » W: Mike Marshall (3-6) L: Ron Schueler (3-3) | Sixth | 7 out |
| Monday, July 3 |
| » Defeated Brewers (45-33), 7-2 | Metropolitan Stadium (14-19) | 33-42 | Won 2 |
| » W: Roger Erickson (9-5) L: Jerry Augustine (9-9) | Sixth | 7 out |
| Tuesday, July 4 |
| » Defeated Brewers (45-34), 7-2 | Metropolitan Stadium (15-19) | 34-42 | Won 3 |
| » W: Gary Serum (4-3) L: Bill Travers (4-4) | Sixth | 6 out |
| Wednesday, July 5 |
| » Defeated Brewers (45-35), 3-1 | Metropolitan Stadium (16-19) | 35-42 | Won 4 |
| » W: Dave Goltz (7-5) L: Lary Sorensen (11-5) | Sixth | 5½ out |
| Friday, July 7 |
| » Defeated Athletics (43-41), 3-2 | Oakland-Alameda County Stadium (2-3) | 36-42 | Won 5 |
| » W: Geoff Zahn (8-6) L: Steve Renko (3-4) S: Mike Marshall (11) | Fifth | 5 out |
| » Defeated Athletics (43-42), 1-0 | Oakland-Alameda County Stadium (3-3) | 37-42 | Won 6 |
| » W: Darrell Jackson (2-1) L: Rick Langford (1-7) | Fifth | 5 out |
| Saturday, July 8 |
| » Defeated Athletics (43-43), 9-8 | Oakland-Alameda County Stadium (4-3) | 38-42 | Won 7 |
| » W: Mike Marshall (4-6) L: Dave Heaverlo (3-4) | Fifth | 5½ out |
| Sunday, July 9 |
| » Defeated Athletics (43-44), 7-0 | Oakland-Alameda County Stadium (5-3) | 39-42 | Won 8 |
| » W: Dave Goltz (8-5) L: Pete Broberg (9-7) | Fifth | 4½ out |
| Thursday, July 13 |
| » Lost to Orioles (46-40), 8-6 | Memorial Stadium (2-2) | 39-43 | |
| » W: Mike Flanagan (13-6) L: Dave Goltz (8-6) S: Tippy Martinez (3) | Fifth | 5½ out |
| Friday, July 14 |
| » Lost to Orioles (47-40), 5-1 | Memorial Stadium (2-3) | 39-44 | Lost 2 |
| » W: Scott McGregor (9-8) L: Geoff Zahn (8-7) | Fifth | 6½ out |
| Saturday, July 15 |
| » Lost to Red Sox (58-28), 5-4 | Fenway Park (0-3) | 39-45 | Lost 3 |
| » W: Bill Lee (10-3) L: Darrell Jackson (2-2) S: Bob Stanley (6) | Fifth | 7½ out |
| Sunday, July 16 |
| » Lost to Red Sox (59-28), 5-3 | Fenway Park (0-4) | 39-46 | Lost 4 |
| » W: Dennis Eckersley (11-2) L: Roric Harrison (0-1) S: Bill Campbell (4) | Fifth | 8 out |
| » Lost to Red Sox (60-28), 3-2 | Fenway Park (0-5) | 39-47 | Lost 5 |
| » W: Jim Wright (5-1) L: Roger Erickson (9-6) S: Bob Stanley (7) | Fifth | 8 out |
| » Major-league debuts: Garry Hancock (Red Sox) |
| Monday, July 17 |
| » Lost to Red Sox (61-28), 3-2 | Fenway Park (0-6) | 39-48 | Lost 6 |
| » W: Bill Campbell (6-5) L: Mike Marshall (4-7) | Fifth | 8 out |
| Wednesday, July 19 |
| » Lost to Yankees (48-42), 2-0 | Metropolitan Stadium (16-20) | 39-49 | Lost 7 |
| » W: Ed Figueroa (8-7) L: Geoff Zahn (8-8) | Fifth | 9 out |
| Thursday, July 20 |
| » Lost to Yankees (49-42), 4-0 | Metropolitan Stadium (16-21) | 39-50 | Lost 8 |
| » W: Ron Guidry (14-1) L: Darrell Jackson (2-3) | Fifth | 10 out |
| Friday, July 21 |
| » Lost to Orioles (52-42), 5-4 | Metropolitan Stadium (16-22) | 39-51 | Lost 9 |
| » W: Don Stanhouse (4-5) L: Mike Marshall (4-8) | Fifth | 11 out |
| Saturday, July 22 |
| » Defeated Orioles (52-43), 5-4 | Metropolitan Stadium (17-22) | 40-51 | |
| » W: Dave Goltz (9-6) L: Scott McGregor (10-9) | Fifth | 11 out |
| Sunday, July 23 |
| » Lost to Orioles (53-43), 8-5 | Metropolitan Stadium (17-23) | 40-52 | |
| » W: Jim Palmer (12-8) L: Gary Serum (4-4) S: Don Stanhouse (13) | Fifth | 12 out |
| Monday, July 24 |
| » Defeated Red Sox (62-33), 5-4 | Metropolitan Stadium (18-23) | 41-52 | |
| » W: Darrell Jackson (3-3) L: Dick Drago (2-4) S: Mike Marshall (12) | Fifth | 12½ out |
| » Lost to Red Sox (63-33), 4-2 | Metropolitan Stadium (18-24) | 41-53 | |
| » W: Andy Hassler (2-4) L: Geoff Zahn (8-9) S: Bob Stanley (8) | Fifth | 12½ out |
| Tuesday, July 25 |
| » Defeated Red Sox (63-34), 5-2 | Metropolitan Stadium (19-24) | 42-53 | |
| » W: Roger Erickson (10-6) L: Bill Lee (10-5) S: Mike Marshall (13) | Fifth | 11½ out |
| Wednesday, July 26 |
| » Lost to Blue Jays (36-64), 5-1 | Metropolitan Stadium (19-25) | 42-54 | |
| » W: Balor Moore (5-2) L: Dave Goltz (9-7) | Fifth | 12½ out |
| Thursday, July 27 |
| » Defeated Blue Jays (36-65), 6-3 | Metropolitan Stadium (20-25) | 43-54 | |
| » W: Stan Perzanowski (1-0) L: Jim Clancy (7-8) | Fifth | 12½ out |
| Friday, July 28 |
| » Defeated Yankees (55-45), 7-5 | Yankee Stadium (1-1) | 44-54 | Won 2 |
| » W: Mike Marshall (5-8) L: Sparky Lyle (7-2) | Fifth | 12½ out |
| Saturday, July 29 |
| » Lost to Yankees (56-45), 7-3 | Yankee Stadium (1-2) | 44-55 | |
| » W: Ken Clay (2-3) L: Darrell Jackson (3-4) S: Rich Gossage (15) | Fifth | 12½ out |
| » Major-league debuts: Ron Davis (Yankees) |
| Sunday, July 30 |
| » Lost to Yankees (57-45), 4-3 | Yankee Stadium (1-3) | 44-56 | Lost 2 |
| » W: Rich Gossage (7-9) L: Mike Marshall (5-9) | Fifth | 13 out |
| » Defeated Yankees (57-46), 2-0 | Yankee Stadium (2-3) | 45-56 | |
| » W: Dave Goltz (10-7) L: Jim Beattie (2-5) S: Mike Marshall (14) | Fifth | 13 out |
| Tuesday, August 1 |
| » Lost to Mariners (37-69), 13-6 | Kingdome (3-3) | 45-57 | |
| » W: Tom House (5-4) L: Stan Perzanowski (1-1) | Fourth | 12½ out |
| Wednesday, August 2 |
| » Lost to Mariners (38-69), 3-1 | Kingdome (3-4) | 45-58 | Lost 2 |
| » W: Jim Colborn (3-8) L: Geoff Zahn (8-10) | Fifth | 12½ out |
| Future Twin Matt Guerrier is born in Cleveland, OH. |
| Thursday, August 3 |
| » Lost to Mariners (39-69), 6-5 | Kingdome (3-5) | 45-59 | Lost 3 |
| » W: Enrique Romo (9-3) L: Mike Marshall (5-10) | Fifth | 13 out |
| Friday, August 4 |
| » Lost to Angels (59-51), 12-3 | Anaheim Stadium (1-4) | 45-60 | Lost 4 |
| » W: Al Fitzmorris (1-1) L: Gary Serum (4-5) S: Ken Brett (1) | Fifth | 13 out |
| Saturday, August 5 |
| » Defeated Angels (59-52), 4-3 | Anaheim Stadium (2-4) | 46-60 | |
| » W: Roger Erickson (11-6) L: Frank Tanana (14-7) | Fifth | 13½ out |
| » Lost to Angels (60-52), 4-3 | Anaheim Stadium (2-5) | 46-61 | |
| » W: Chris Knapp (11-6) L: Stan Perzanowski (1-2) S: Dave LaRoche (16) | Fifth | 13½ out |
| Sunday, August 6 |
| » Lost to Angels (61-52), 4-3 | Anaheim Stadium (2-6) | 46-62 | Lost 2 |
| » W: Dave LaRoche (8-5) L: Mike Marshall (5-11) | Fifth | 14½ out |
| Monday, August 7 |
| » Lost to Mariners (41-72), 6-5 | Metropolitan Stadium (20-26) | 46-63 | Lost 3 |
| » W: Jim Todd (2-3) L: Stan Perzanowski (1-3) | Fifth | 14½ out |
| Tuesday, August 8 |
| » Defeated Mariners (41-73), 10-2 | Metropolitan Stadium (21-26) | 47-63 | |
| » W: Gary Serum (5-5) L: Rick Honeycutt (4-7) | Fifth | 14½ out |
| Wednesday, August 9 |
| » Lost to Mariners (42-73), 4-1 | Metropolitan Stadium (21-27) | 47-64 | |
| » W: Glenn Abbott (5-9) L: Roger Erickson (11-7) S: Jim Todd (2) | Fifth | 15½ out |
| Friday, August 11 |
| » Lost to Athletics (61-56), 2-0 | Metropolitan Stadium (21-28) | 47-65 | Lost 2 |
| » W: Rick Langford (6-7) L: Geoff Zahn (8-11) | Fifth | 15½ out |
| » Defeated Athletics (61-57), 3-2 | Metropolitan Stadium (22-28) | 48-65 | |
| » W: Darrell Jackson (4-4) L: Pete Broberg (9-10) S: Mike Marshall (15) | Fifth | 15½ out |
| Saturday, August 12 |
| » Defeated Athletics (61-58), 6-3 | Metropolitan Stadium (23-28) | 49-65 | Won 2 |
| » W: Stan Perzanowski (2-3) L: Steve Renko (6-7) S: Mike Marshall (16) | Fifth | 14½ out |
| Sunday, August 13 |
| » Defeated Athletics (61-59), 3-1 | Metropolitan Stadium (24-28) | 50-65 | Won 3 |
| » W: Gary Serum (6-5) L: Matt Keough (7-10) | Fifth | 13 out |
| » Defeated Athletics (61-60), 2-1 | Metropolitan Stadium (25-28) | 51-65 | Won 4 |
| » W: Roger Erickson (12-7) L: Mike Norris (0-1) | Fifth | 13 out |
| Monday, August 14 |
| » Lost to Indians (53-63), 4-3 | Cleveland Stadium (0-4) | 51-66 | |
| » W: Mike Paxton (9-6) L: Jeff Holly (0-1) S: Jim Kern (10) | Fifth | 13 out |
| Tuesday, August 15 |
| » Defeated Indians (53-64), 9-8 | Cleveland Stadium (1-4) | 52-66 | |
| » W: Mike Marshall (6-11) L: Sid Monge (3-2) S: Gary Serum (1) | Fifth | 13 out |
| Wednesday, August 16 |
| » Defeated Royals (64-53), 5-1 | Metropolitan Stadium (26-28) | 53-66 | Won 2 |
| » W: Geoff Zahn (9-11) L: Doug Bird (4-6) | Fifth | 13 out |
| » Lost to Royals (65-53), 11-7 | Metropolitan Stadium (26-29) | 53-67 | |
| » W: Paul Splittorff (14-10) L: Stan Perzanowski (2-4) S: Steve Mingori (7) | Fifth | 13 out |
| Thursday, August 17 |
| » Defeated Royals (65-54), 6-5 | Metropolitan Stadium (27-29) | 54-67 | |
| » W: Roger Erickson (13-7) L: Larry Gura (10-3) | Fifth | 12 out |
| Friday, August 18 |
| » Defeated Blue Jays (46-75), 4-3 | Metropolitan Stadium (28-29) | 55-67 | Won 2 |
| » W: Jeff Holly (1-1) L: Tom Murphy (4-9) | Fifth | 11 out |
| Saturday, August 19 |
| » Defeated Blue Jays (46-76), 5-0 | Metropolitan Stadium (29-29) | 56-67 | Won 3 |
| » W: Gary Serum (7-5) L: Jerry Garvin (3-12) | Fifth | 11 out |
| Sunday, August 20 |
| » Lost to Blue Jays (47-76), 6-2 | Metropolitan Stadium (29-30) | 56-68 | |
| » W: Don Kirkwood (2-1) L: Stan Perzanowski (2-5) S: Tom Murphy (7) | Fifth | 12 out |
| Monday, August 21 |
| » Lost to Tigers (68-54), 9-6 | Metropolitan Stadium (29-31) | 56-69 | Lost 2 |
| » W: Jack Billingham (14-5) L: Geoff Zahn (9-12) | Fifth | 12½ out |
| Tuesday, August 22 |
| » Lost to Tigers (69-54), 7-3 | Metropolitan Stadium (29-32) | 56-70 | Lost 3 |
| » W: Jim Slaton (13-9) L: Stan Perzanowski (2-6) | Fifth | 13½ out |
| Wednesday, August 23 |
| » Lost to Rangers (61-63), 2-0 | Metropolitan Stadium (29-33) | 56-71 | Lost 4 |
| » W: Steve Comer (6-3) L: Roger Erickson (13-8) | Fifth | 13½ out |
| Thursday, August 24 |
| » Lost to Rangers (62-63), 4-1 | Metropolitan Stadium (29-34) | 56-72 | Lost 5 |
| » W: Fergie Jenkins (12-8) L: Dave Goltz (10-8) | Fifth | 14 out |
| Friday, August 25 |
| » Lost to Blue Jays (52-77), 7-3 | Exhibition Stadium (2-1) | 56-73 | Lost 6 |
| » W: Don Kirkwood (3-1) L: Gary Serum (7-6) S: Mike Willis (7) | Fifth | 14 out |
| Saturday, August 26 |
| » Lost to Blue Jays (53-77), 4-3 | Exhibition Stadium (2-2) | 56-74 | Lost 7 |
| » W: Victor Cruz (5-1) L: Geoff Zahn (9-13) | Fifth | 14 out |
| Sunday, August 27 |
| » Defeated Blue Jays (53-78), 3-2 | Exhibition Stadium (3-2) | 57-74 | |
| » W: Mike Marshall (7-11) L: Mike Willis (2-6) | Fifth | 13½ out |
| Tuesday, August 29 |
| » Lost to Tigers (73-58), 4-2 | Tiger Stadium (2-2) | 57-75 | |
| » W: Milt Wilcox (12-8) L: Dave Goltz (10-9) | Fifth | 14 out |
| Thursday, August 31 |
| » Defeated Tigers (73-59), 4-1 | Tiger Stadium (3-2) | 58-75 | |
| » W: Geoff Zahn (10-13) L: Kip Young (5-4) S: Mike Marshall (17) | Fifth | 14 out |
| Friday, September 1 |
| » Lost to Indians (58-75), 4-1 | Metropolitan Stadium (29-35) | 58-76 | |
| » W: David Clyde (6-9) L: Roger Erickson (13-9) S: Dan Spillner (3) | Fifth | 14 out |
| Saturday, September 2 |
| » Defeated Indians (58-76), 2-1 | Metropolitan Stadium (30-35) | 59-76 | |
| » W: Dave Goltz (11-9) L: Paul Reuschel (4-2) S: Mike Marshall (18) | Fifth | 14 out |
| Sunday, September 3 |
| » Defeated Indians (58-77), 12-3 | Metropolitan Stadium (31-35) | 60-76 | Won 2 |
| » W: Gary Serum (8-6) L: Rick Wise (9-18) | Fifth | 13½ out |
| » Defeated Indians (58-78), 4-3 | Metropolitan Stadium (32-35) | 61-76 | Won 3 |
| » W: Mike Marshall (8-11) L: Jim Kern (8-9) | Fifth | 13½ out |
| Monday, September 4 |
| » Defeated White Sox (57-80), 2-1 | Metropolitan Stadium (33-35) | 62-76 | Won 4 |
| » W: Geoff Zahn (11-13) L: Francisco Barrios (8-13) | Fifth | 13½ out |
| Tuesday, September 5 |
| » Lost to White Sox (58-80), 4-3 | Metropolitan Stadium (33-36) | 62-77 | |
| » W: Steve Trout (1-0) L: Roger Erickson (13-10) S: Lerrin LaGrow (15) | Fifth | 14½ out |
| Wednesday, September 6 |
| » Lost to White Sox (59-80), 1-0 | Metropolitan Stadium (33-37) | 62-78 | Lost 2 |
| » W: Ken Kravec (11-13) L: Dave Goltz (11-10) | Fifth | 15½ out |
| Thursday, September 7 |
| » Major-league debuts: Harry Chappas (White Sox) |
| Friday, September 8 |
| » Lost to Brewers (81-60), 3-0 | Metropolitan Stadium (33-38) | 62-79 | Lost 3 |
| » W: Andy Replogle (8-2) L: Gary Serum (8-7) | Fifth | 16½ out |
| Saturday, September 9 |
| » Lost to Brewers (82-60), 3-0 | Metropolitan Stadium (33-39) | 62-80 | Lost 4 |
| » W: Mike Caldwell (18-9) L: Roger Erickson (13-11) | Fifth | 16 out |
| Sunday, September 10 |
| » Defeated Brewers (82-61), 3-1 | Metropolitan Stadium (34-39) | 63-80 | |
| » W: Dave Goltz (12-10) L: Bill Travers (10-9) | Fifth | 15 out |
| Monday, September 11 |
| » Defeated White Sox (61-83), 3-1 | Comiskey Park I (4-2) | 64-80 | Won 2 |
| » W: Geoff Zahn (12-13) L: Ken Kravec (11-14) S: Mike Marshall (19) | Fifth | 15 out |
| » Major-league debuts: Dave Edwards (Twins) |
| Tuesday, September 12 |
| » Lost to White Sox (62-83), 6-1 | Comiskey Park I (4-3) | 64-81 | |
| » W: Rich Hinton (2-4) L: Gary Serum (8-8) | Fifth | 16 out |
| Thursday, September 14 |
| » Major-league debuts: Tom Brown (Mariners) |
| Friday, September 15 |
| » Defeated Brewers (85-63), 10-3 | County Stadium (1-2) | 65-81 | |
| » W: Roger Erickson (14-11) L: Bill Travers (10-10) | Fifth | 17 out |
| Saturday, September 16 |
| » Defeated Brewers (85-64), 5-2 | County Stadium (2-2) | 66-81 | Won 2 |
| » W: Dave Goltz (13-10) L: Lary Sorensen (17-11) S: Mike Marshall (20) | Fourth | 16 out |
| Sunday, September 17 |
| » Defeated Brewers (85-65), 4-3 | County Stadium (3-2) | 67-81 | Won 3 |
| » W: Gary Serum (9-8) L: Andy Replogle (9-3) S: Mike Marshall (21) | Fourth | 16 out |
| Monday, September 18 |
| » Defeated Angels (80-72), 10-4 | Metropolitan Stadium (35-39) | 68-81 | Won 4 |
| » W: Geoff Zahn (13-13) L: Chris Knapp (14-8) S: Stan Perzanowski (1) | Fourth | 16 out |
| Tuesday, September 19 |
| » Lost to Angels (81-72), 4-1 | Metropolitan Stadium (35-40) | 68-82 | |
| » W: Nolan Ryan (8-13) L: Roger Erickson (14-12) | Fourth | 17 out |
| Wednesday, September 20 |
| » Defeated Rangers (75-74), 5-3 | Metropolitan Stadium (36-40) | 69-82 | |
| » W: Dave Goltz (14-10) L: Steve Comer (9-5) | Fourth | 16 out |
| Thursday, September 21 |
| » Lost to Rangers (76-74), 6-3 | Metropolitan Stadium (36-41) | 69-83 | |
| » W: Jon Matlack (14-13) L: Gary Serum (9-9) | Fourth | 17 out |
| Friday, September 22 |
| » Lost to Royals (87-66), 4-2 | Metropolitan Stadium (36-42) | 69-84 | Lost 2 |
| » W: Larry Gura (15-4) L: Darrell Jackson (4-5) | Fourth | 17 out |
| » Defeated Royals (87-67), 4-0 | Metropolitan Stadium (37-42) | 70-84 | |
| » W: Geoff Zahn (14-13) L: Marty Pattin (3-3) | Fourth | 17 out |
| Saturday, September 23 |
| » Lost to Royals (88-67), 3-1 | Metropolitan Stadium (37-43) | 70-85 | |
| » W: Paul Splittorff (19-12) L: Roger Erickson (14-13) S: Al Hrabosky (20) | Fourth | 18 out |
| Former Twin Lyman Bostock dies in Gary, IN at the age of 28. |
| Sunday, September 24 |
| » Defeated Royals (88-68), 6-4 | Metropolitan Stadium (38-43) | 71-85 | |
| » W: Dave Goltz (15-10) L: Steve Mingori (1-4) | Fourth | 17 out |
| Monday, September 25 |
| » Lost to Rangers (82-74), 3-2 | Arlington Stadium (2-3) | 71-86 | |
| » W: Reggie Cleveland (5-8) L: Mike Marshall (8-12) | Fourth | 18 out |
| Tuesday, September 26 |
| » Defeated Rangers (82-75), 6-2 | Arlington Stadium (3-3) | 72-86 | |
| » W: Mike Marshall (9-12) L: Paul Mirabella (2-2) | Fourth | 18 out |
| Wednesday, September 27 |
| » Lost to Rangers (83-75), 10-5 | Arlington Stadium (3-4) | 72-87 | |
| » W: Paul Mirabella (3-2) L: Stan Perzanowski (2-7) | Fourth | 18 out |
| Friday, September 29 |
| » Lost to Royals (91-69), 4-0 | Royals Stadium (3-2) | 72-88 | Lost 2 |
| » W: Dennis Leonard (21-17) L: Darrell Jackson (4-6) | Fourth | 19 out |
| Saturday, September 30 |
| » Defeated Royals (91-70), 7-3 | Royals Stadium (4-2) | 73-88 | |
| » W: Mike Marshall (10-12) L: Randy McGilberry (0-1) | Third | 18 out |
| Sunday, October 1 |
| » Lost to Royals (92-70), 1-0 | Royals Stadium (4-3) | 73-89 | |
| » W: George Throop (1-0) L: Geoff Zahn (14-14) S: Bill Paschall (1) | Third | 19 out |
| Monday, December 4 |
| Future Twin Kyle Lohse is born in Chico, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |