| Friday, January 6 |
| Future Red Sox Casey Fossum is born in Cherry Hill, NJ. |
| Saturday, January 7 |
| Former Red Sox George Burns dies in Kirkland, WA at the age of 85. |
| Thursday, January 19 |
| Future Red Sox Wilton Veras is born in Monte Cristi, D.R. |
| Tuesday, March 21 |
| Former Red Sox Fritz Coumbe dies in Paradise, CA at the age of 89. |
| Wednesday, April 5 |
| » Major-league debuts: Hosken Powell (Twins) |
| Friday, April 7 |
| » Lost to White Sox (1-0), 6-5 | Comiskey Park I (0-1) | 0-1 | |
| » W: Lerrin LaGrow (1-0) L: Dick Drago (0-1) | Third | 1 out |
| Saturday, April 8 |
| » Lost to White Sox (2-0), 6-5 | Comiskey Park I (0-2) | 0-2 | Lost 2 |
| » W: Pablo Torrealba (1-0) L: Bill Campbell (0-1) S: Lerrin LaGrow (1) | Fifth | 2 out |
| Sunday, April 9 |
| » Defeated White Sox (2-1), 5-0 | Comiskey Park I (1-2) | 1-2 | |
| » W: Bill Lee (1-0) L: Wilbur Wood (0-1) | Fourth | 2 out |
| Monday, April 10 |
| » Lost to Indians (2-1), 5-4 | Cleveland Stadium (0-1) | 1-3 | |
| » W: Jim Kern (1-0) L: Reggie Cleveland (0-1) | Fourth | 2½ out |
| » Major-league debuts: Allen Ripley (Red Sox) |
| Tuesday, April 11 |
| Future Red Sox Josh Hancock is born in Cleveland, MS. |
| Wednesday, April 12 |
| » Defeated Indians (2-2), 6-3 | Cleveland Stadium (1-1) | 2-3 | |
| » W: Mike Torrez (1-0) L: Wayne Garland (1-1) S: Dick Drago (1) | Fourth | 3 out |
| Friday, April 14 |
| » Defeated Rangers (2-4), 5-4 | Fenway Park (1-0) | 3-3 | Won 2 |
| » W: Dick Drago (1-1) L: Len Barker (0-1) | Third | 2 out |
| Saturday, April 15 |
| » Defeated Rangers (2-5), 12-4 | Fenway Park (2-0) | 4-3 | Won 3 |
| » W: Bill Lee (2-0) L: Dock Ellis (1-1) | Second | 1 out |
| » Major-league debuts: Steve Comer (Rangers) |
| Sunday, April 16 |
| » Defeated Rangers (2-6), 8-6 | Fenway Park (3-0) | 5-3 | Won 4 |
| » W: Bob Stanley (1-0) L: Jim Umbarger (0-1) S: Tom Burgmeier (1) | Third | 1 out |
| Monday, April 17 |
| » Defeated Brewers (6-4), 9-2 | Fenway Park (4-0) | 6-3 | Won 5 |
| » W: Mike Torrez (2-0) L: Randy Stein (0-1) | Second | 1 out |
| Tuesday, April 18 |
| » Defeated Brewers (6-5), 7-6 | Fenway Park (5-0) | 7-3 | Won 6 |
| » W: Luis Tiant (1-0) L: Eduardo Rodriguez (0-1) | Second | ½ out |
| Thursday, April 20 |
| » Defeated Brewers (6-6), 10-4 | Fenway Park (6-0) | 8-3 | Won 7 |
| » W: Bill Lee (3-0) L: Moose Haas (2-2) | Second | 1 out |
| Friday, April 21 |
| » Defeated Indians (3-6), 9-7 | Fenway Park (7-0) | 9-3 | Won 8 |
| » W: Dick Drago (2-1) L: Jim Kern (1-1) | Second | 1½ out |
| Saturday, April 22 |
| » Lost to Indians (4-6), 13-4 | Fenway Park (7-1) | 9-4 | |
| » W: Rick Wise (1-2) L: Allen Ripley (0-1) | Second | 1½ out |
| » Major-league debuts: Wayne Cage (Indians) |
| Sunday, April 23 |
| » Defeated Indians (4-7), 6-3 | Fenway Park (8-1) | 10-4 | |
| » W: Bill Campbell (1-1) L: Dennis Kinney (0-1) | Second | 1½ out |
| » Lost to Indians (5-7), 10-7 | Fenway Park (8-2) | 10-5 | |
| » W: Jim Kern (2-1) L: Bob Stanley (1-1) S: Dennis Kinney (1) | Second | 1½ out |
| » Major-league debuts: Ron Hassey (Indians) |
| Tuesday, April 25 |
| » Defeated Brewers (8-8), 4-3 | County Stadium (1-0) | 11-5 | |
| » W: Bill Lee (4-0) L: Jerry Augustine (3-2) S: Dick Drago (2) | Second | 1 out |
| Wednesday, April 26 |
| » Lost to Brewers (9-8), 6-4 | County Stadium (1-1) | 11-6 | |
| » W: Mike Caldwell (1-0) L: Mike Torrez (2-1) S: Bob McClure (2) | Second | 1 out |
| Friday, April 28 |
| » Lost to Rangers (7-10), 5-4 | Arlington Stadium (0-1) | 11-7 | Lost 2 |
| » W: Reggie Cleveland (1-2) L: Bill Campbell (1-2) | Second | 2 out |
| Saturday, April 29 |
| » Lost to Rangers (8-10), 4-1 | Arlington Stadium (0-2) | 11-8 | Lost 3 |
| » W: Dock Ellis (2-1) L: Dennis Eckersley (0-1) | Second | 3 out |
| Sunday, April 30 |
| » Lost to Rangers (9-10), 2-1 | Arlington Stadium (0-3) | 11-9 | Lost 4 |
| » W: Fergie Jenkins (2-1) L: Bill Campbell (1-3) | Second | 3 out |
| Monday, May 1 |
| » Defeated Orioles (8-12), 9-6 | Fenway Park (9-2) | 12-9 | |
| » W: Mike Torrez (3-1) L: Nelson Briles (1-2) S: Bob Stanley (1) | Second | 2½ out |
| Tuesday, May 2 |
| » Lost to Orioles (9-12), 3-1 | Fenway Park (9-3) | 12-10 | |
| » W: Dennis Martinez (3-1) L: Allen Ripley (0-2) | Third | 3½ out |
| Wednesday, May 3 |
| » Defeated Twins (8-17), 11-9 | Fenway Park (10-3) | 13-10 | |
| » W: Tom Burgmeier (1-0) L: Dave Johnson (0-2) S: Bob Stanley (2) | Third | 3½ out |
| Thursday, May 4 |
| » Defeated Twins (8-18), 8-1 | Fenway Park (11-3) | 14-10 | Won 2 |
| » W: Dennis Eckersley (1-1) L: Paul Thormodsgard (1-3) | Third | 3 out |
| Saturday, May 6 |
| » Defeated White Sox (7-14), 6-4 | Fenway Park (12-3) | 15-10 | Won 3 |
| » W: Bob Stanley (2-1) L: Jim Willoughby (0-2) | Second | 2 out |
| » Defeated White Sox (7-15), 3-0 | Fenway Park (13-3) | 16-10 | Won 4 |
| » W: Jim Wright (1-0) L: Francisco Barrios (1-2) | Second | 2 out |
| Sunday, May 7 |
| » Defeated White Sox (7-16), 5-0 | Fenway Park (14-3) | 17-10 | Won 5 |
| » W: Mike Torrez (4-1) L: Pablo Torrealba (1-4) | Second | 2 out |
| Monday, May 8 |
| » Defeated Royals (15-11), 8-4 | Fenway Park (15-3) | 18-10 | Won 6 |
| » W: Bob Stanley (3-1) L: Dennis Leonard (3-5) | Second | 2½ out |
| Tuesday, May 9 |
| » Defeated Royals (15-12), 4-3 | Fenway Park (16-3) | 19-10 | Won 7 |
| » W: Dennis Eckersley (2-1) L: Jim Colborn (1-2) | Second | 2½ out |
| Wednesday, May 10 |
| » Lost to Orioles (11-15), 3-2 | Memorial Stadium (0-1) | 19-11 | |
| » W: Mike Flanagan (3-3) L: Tom Burgmeier (1-1) | Second | 3 out |
| Thursday, May 11 |
| » Defeated Orioles (11-16), 5-4 | Memorial Stadium (1-1) | 20-11 | |
| » W: Bill Lee (5-0) L: Dennis Martinez (3-2) S: Dick Drago (3) | Second | 3½ out |
| Saturday, May 13 |
| » Defeated Twins (10-22), 4-2 | Metropolitan Stadium (1-0) | 21-11 | Won 2 |
| » W: Mike Torrez (5-1) L: Geoff Zahn (2-2) S: Tom Burgmeier (2) | First | -- |
| Sunday, May 14 |
| » Defeated Twins (10-23), 6-2 | Metropolitan Stadium (2-0) | 22-11 | Won 3 |
| » W: Dennis Eckersley (3-1) L: Paul Thormodsgard (1-5) S: Tom Burgmeier (3) | First | -- |
| Monday, May 15 |
| » Lost to Royals (18-13), 3-1 | Royals Stadium (0-1) | 22-12 | |
| » W: Rich Gale (3-0) L: Allen Ripley (0-3) | Second | 3 out |
| Tuesday, May 16 |
| » Defeated Royals (18-14), 3-2 | Royals Stadium (1-1) | 23-12 | |
| » W: Bill Lee (6-0) L: Paul Splittorff (4-3) | Second | 3 out |
| Friday, May 19 |
| » Lost to Tigers (22-10), 7-5 | Tiger Stadium (0-1) | 23-13 | |
| » W: Bob Sykes (3-0) L: Mike Torrez (5-2) S: John Hiller (4) | Second | 2 out |
| Saturday, May 20 |
| » Defeated Tigers (22-11), 6-5 | Tiger Stadium (1-1) | 24-13 | |
| » W: Bill Campbell (2-3) L: Steve Foucault (1-4) | Second | 2 out |
| Sunday, May 21 |
| » Lost to Tigers (23-11), 2-1 | Tiger Stadium (1-2) | 24-14 | |
| » W: Milt Wilcox (3-1) L: Bill Lee (6-1) | Second | 2 out |
| » Defeated Tigers (23-12), 9-3 | Tiger Stadium (2-2) | 25-14 | |
| » W: Luis Tiant (2-0) L: Dave Rozema (2-2) | Second | 2 out |
| Monday, May 22 |
| » Defeated Blue Jays (14-24), 5-4 | Exhibition Stadium (1-0) | 26-14 | Won 2 |
| » W: Allen Ripley (1-3) L: Jim Clancy (2-4) S: Bob Stanley (3) | Second | 2½ out |
| Tuesday, May 23 |
| » Lost to Blue Jays (15-24), 2-1 | Exhibition Stadium (1-1) | 26-15 | |
| » W: Jesse Jefferson (3-5) L: Bill Campbell (2-4) | Second | 2½ out |
| Wednesday, May 24 |
| » Defeated Blue Jays (15-25), 8-2 | Exhibition Stadium (2-1) | 27-15 | |
| » W: Mike Torrez (6-2) L: Dave Lemanczyk (1-8) | First | -- |
| Thursday, May 25 |
| » Defeated Blue Jays (15-26), 9-5 | Exhibition Stadium (3-1) | 28-15 | Won 2 |
| » W: Dennis Eckersley (4-1) L: Tom Underwood (1-5) S: Dick Drago (4) | First | -- |
| Friday, May 26 |
| » Defeated Tigers (24-16), 6-3 | Fenway Park (17-3) | 29-15 | Won 3 |
| » W: Bill Lee (7-1) L: Milt Wilcox (3-2) | First | -- |
| Saturday, May 27 |
| » Defeated Tigers (24-17), 1-0 | Fenway Park (18-3) | 30-15 | Won 4 |
| » W: Luis Tiant (3-0) L: Jack Morris (0-1) | First | -- |
| Sunday, May 28 |
| » Defeated Tigers (24-18), 4-3 | Fenway Park (19-3) | 31-15 | Won 5 |
| » W: Bob Stanley (4-1) L: John Hiller (4-3) | First | -- |
| » Defeated Tigers (24-19), 4-3 | Fenway Park (20-3) | 32-15 | Won 6 |
| » W: Jim Wright (2-0) L: Jim Slaton (4-2) S: Dick Drago (5) | First | -- |
| Monday, May 29 |
| » Defeated Blue Jays (16-30), 5-4 | Fenway Park (21-3) | 33-15 | Won 7 |
| » W: Mike Torrez (7-2) L: Tom Underwood (1-6) | First | -- |
| Former Red Sox Carl Reynolds dies in Houston, TX at the age of 76. |
| Tuesday, May 30 |
| » Defeated Blue Jays (16-31), 4-0 | Fenway Park (22-3) | 34-15 | Won 8 |
| » W: Dennis Eckersley (5-1) L: Jerry Garvin (2-4) | First | -- |
| Wednesday, May 31 |
| » Lost to Blue Jays (17-31), 6-2 | Fenway Park (22-4) | 34-16 | |
| » W: Jim Clancy (4-4) L: Bill Lee (7-2) | First | -- |
| Friday, June 2 |
| » Defeated Angels (25-22), 6-1 | Anaheim Stadium (1-0) | 35-16 | |
| » W: Luis Tiant (4-0) L: Nolan Ryan (3-5) S: Dick Drago (6) | First | -- |
| Former Red Sox Bob McGraw dies in Boise, ID at the age of 84. |
| Saturday, June 3 |
| » Defeated Angels (25-23), 5-4 | Anaheim Stadium (2-0) | 36-16 | Won 2 |
| » W: Mike Torrez (8-2) L: Paul Hartzell (1-4) S: Bill Campbell (1) | First | -- |
| Sunday, June 4 |
| » Lost to Angels (26-23), 4-2 | Anaheim Stadium (2-1) | 36-17 | |
| » W: Frank Tanana (9-2) L: Dennis Eckersley (5-2) S: Dave LaRoche (7) | First | -- |
| Monday, June 5 |
| » Lost to Athletics (30-21), 9-7 | Oakland-Alameda County Stadium (0-1) | 36-18 | Lost 2 |
| » W: Pete Broberg (6-4) L: Allen Ripley (1-4) S: Elias Sosa (8) | First | -- |
| Tuesday, June 6 |
| » Lost to Athletics (31-21), 7-1 | Oakland-Alameda County Stadium (0-2) | 36-19 | Lost 3 |
| » W: Steve Renko (1-1) L: Bill Lee (7-3) | First | -- |
| Friday, June 9 |
| » Defeated Mariners (19-39), 3-2 | Kingdome (1-0) | 37-19 | |
| » W: Luis Tiant (5-0) L: Paul Mitchell (2-6) | First | -- |
| Saturday, June 10 |
| » Defeated Mariners (19-40), 13-1 | Kingdome (2-0) | 38-19 | Won 2 |
| » W: Mike Torrez (9-2) L: Dick Pole (4-7) | First | -- |
| Sunday, June 11 |
| » Defeated Mariners (19-41), 5-3 | Kingdome (3-0) | 39-19 | Won 3 |
| » W: Dennis Eckersley (6-2) L: Byron McLaughlin (0-3) S: Bill Campbell (2) | First | -- |
| Monday, June 12 |
| » Defeated Angels (30-28), 10-9 | Fenway Park (23-4) | 40-19 | Won 4 |
| » W: Bill Campbell (3-4) L: Dave LaRoche (5-3) | First | -- |
| Tuesday, June 13 |
| » Defeated Angels (30-29), 5-0 | Fenway Park (24-4) | 41-19 | Won 5 |
| » W: Jim Wright (3-0) L: Chris Knapp (6-5) | First | -- |
| Wednesday, June 14 |
| » Defeated Athletics (32-29), 9-0 | Fenway Park (25-4) | 42-19 | Won 6 |
| » W: Luis Tiant (6-0) L: Pete Broberg (6-6) | First | -- |
| Thursday, June 15 |
| » Defeated Athletics (32-30), 7-3 | Fenway Park (26-4) | 43-19 | Won 7 |
| » W: Mike Torrez (10-2) L: Bob Lacey (5-3) | First | -- |
| Friday, June 16 |
| » Defeated Mariners (19-46), 6-3 | Fenway Park (27-4) | 44-19 | Won 8 |
| » W: Bill Campbell (4-4) L: Dick Pole (4-8) | First | -- |
| Saturday, June 17 |
| » Defeated Mariners (19-47), 5-4 | Fenway Park (28-4) | 45-19 | Won 9 |
| » W: Bob Stanley (5-1) L: John Montague (0-3) | First | -- |
| Sunday, June 18 |
| » Lost to Mariners (20-47), 3-2 | Fenway Park (28-5) | 45-20 | |
| » W: Glenn Abbott (2-4) L: Jim Wright (3-1) | First | -- |
| Monday, June 19 |
| » Defeated Yankees (37-27), 10-4 | Fenway Park (29-5) | 46-20 | |
| » W: Tom Burgmeier (2-1) L: Rich Gossage (3-7) | First | -- |
| Tuesday, June 20 |
| » Lost to Yankees (38-27), 10-4 | Fenway Park (29-6) | 46-21 | |
| » W: Don Gullett (2-0) L: Mike Torrez (10-3) | First | -- |
| Wednesday, June 21 |
| » Defeated Yankees (38-28), 9-2 | Fenway Park (30-6) | 47-21 | |
| » W: Dennis Eckersley (7-2) L: Jim Beattie (2-3) | First | -- |
| Friday, June 23 |
| » Defeated Orioles (40-28), 5-2 | Fenway Park (31-6) | 48-21 | Won 2 |
| » W: Bill Lee (8-3) L: Jim Palmer (10-5) | First | -- |
| Saturday, June 24 |
| » Defeated Orioles (40-29), 8-3 | Fenway Park (32-6) | 49-21 | Won 3 |
| » W: Luis Tiant (7-0) L: Scott McGregor (8-5) | First | -- |
| Sunday, June 25 |
| » Defeated Orioles (40-30), 4-1 | Fenway Park (33-6) | 50-21 | Won 4 |
| » W: Mike Torrez (11-3) L: Dennis Martinez (6-5) | First | -- |
| Monday, June 26 |
| » Defeated Yankees (41-30), 4-1 | Yankee Stadium (1-0) | 51-21 | Won 5 |
| » W: Dennis Eckersley (8-2) L: Andy Messersmith (0-2) S: Bill Campbell (3) | First | -- |
| Tuesday, June 27 |
| » Lost to Yankees (42-30), 6-4 | Yankee Stadium (1-1) | 51-22 | |
| » W: Sparky Lyle (6-1) L: Dick Drago (2-2) | First | -- |
| Thursday, June 29 |
| » Defeated Orioles (40-35), 4-3 | Memorial Stadium (2-1) | 52-22 | |
| » W: Allen Ripley (2-4) L: Dennis Martinez (6-6) | First | -- |
| Friday, June 30 |
| » Lost to Orioles (41-35), 3-2 | Memorial Stadium (2-2) | 52-23 | |
| » W: Don Stanhouse (2-5) L: Luis Tiant (7-1) | First | -- |
| Saturday, July 1 |
| » Lost to Orioles (42-35), 3-2 | Memorial Stadium (2-3) | 52-24 | Lost 2 |
| » W: Nelson Briles (2-4) L: Mike Torrez (11-4) | First | -- |
| Monday, July 3 |
| » Defeated Yankees (45-34), 9-5 | Fenway Park (34-6) | 53-24 | |
| » W: Dennis Eckersley (9-2) L: Ed Figueroa (7-6) | First | -- |
| Wednesday, July 5 |
| » Defeated White Sox (37-43), 9-2 | Comiskey Park I (2-2) | 54-24 | Won 2 |
| » W: Bill Lee (9-3) L: Steve Stone (6-6) S: Bob Stanley (4) | First | -- |
| Thursday, July 6 |
| » Defeated White Sox (37-44), 7-6 | Comiskey Park I (3-2) | 55-24 | Won 3 |
| » W: Bill Campbell (5-4) L: Jim Willoughby (1-6) | First | -- |
| Friday, July 7 |
| » Lost to Indians (38-44), 10-9 | Cleveland Stadium (1-2) | 55-25 | |
| » W: Dan Spillner (3-0) L: Bill Campbell (5-5) | First | -- |
| Saturday, July 8 |
| » Defeated Indians (38-45), 12-5 | Cleveland Stadium (2-2) | 56-25 | |
| » W: Dennis Eckersley (10-2) L: Mike Paxton (6-5) | First | -- |
| » Defeated Indians (38-46), 3-2 | Cleveland Stadium (3-2) | 57-25 | Won 2 |
| » W: Jim Wright (4-1) L: David Clyde (4-5) S: Bob Stanley (5) | First | -- |
| Sunday, July 9 |
| » Lost to Indians (39-46), 7-1 | Cleveland Stadium (3-3) | 57-26 | |
| » W: Rick Wise (7-11) L: Allen Ripley (2-5) | First | -- |
| Thursday, July 13 |
| » Lost to Rangers (43-41), 12-7 | Fenway Park (34-7) | 57-27 | Lost 2 |
| » W: Dock Ellis (8-4) L: Luis Tiant (7-2) | First | -- |
| Friday, July 14 |
| » Lost to Rangers (44-41), 4-3 | Fenway Park (34-8) | 57-28 | Lost 3 |
| » W: Fergie Jenkins (9-4) L: Mike Torrez (11-5) S: Reggie Cleveland (9) | First | -- |
| Saturday, July 15 |
| » Defeated Twins (39-45), 5-4 | Fenway Park (35-8) | 58-28 | |
| » W: Bill Lee (10-3) L: Darrell Jackson (2-2) S: Bob Stanley (6) | First | -- |
| Sunday, July 16 |
| » Defeated Twins (39-46), 5-3 | Fenway Park (36-8) | 59-28 | Won 2 |
| » W: Dennis Eckersley (11-2) L: Roric Harrison (0-1) S: Bill Campbell (4) | First | -- |
| » Defeated Twins (39-47), 3-2 | Fenway Park (37-8) | 60-28 | Won 3 |
| » W: Jim Wright (5-1) L: Roger Erickson (9-6) S: Bob Stanley (7) | First | -- |
| » Major-league debuts: Garry Hancock (Red Sox) |
| Monday, July 17 |
| » Defeated Twins (39-48), 3-2 | Fenway Park (38-8) | 61-28 | Won 4 |
| » W: Bill Campbell (6-5) L: Mike Marshall (4-7) | First | -- |
| Tuesday, July 18 |
| » Major-league debuts: Mike Colbern (White Sox) |
| Wednesday, July 19 |
| » Defeated Brewers (53-37), 8-2 | County Stadium (2-1) | 62-28 | Won 5 |
| » W: Mike Torrez (12-5) L: Lary Sorensen (12-6) | First | -- |
| Thursday, July 20 |
| » Lost to Brewers (54-37), 8-6 | County Stadium (2-2) | 62-29 | |
| » W: Eduardo Rodriguez (2-3) L: Bill Lee (10-4) S: Bob McClure (5) | First | -- |
| Friday, July 21 |
| » Lost to Royals (51-41), 9-0 | Royals Stadium (1-2) | 62-30 | Lost 2 |
| » W: Paul Splittorff (11-8) L: Dennis Eckersley (11-3) | First | -- |
| Saturday, July 22 |
| » Lost to Royals (52-41), 6-5 | Royals Stadium (1-3) | 62-31 | Lost 3 |
| » W: Al Hrabosky (4-3) L: Dick Drago (2-3) | First | -- |
| Sunday, July 23 |
| » Lost to Royals (53-41), 7-3 | Royals Stadium (1-4) | 62-32 | Lost 4 |
| » W: Marty Pattin (2-2) L: Jim Wright (5-2) | First | -- |
| Monday, July 24 |
| » Lost to Twins (41-52), 5-4 | Metropolitan Stadium (2-1) | 62-33 | Lost 5 |
| » W: Darrell Jackson (3-3) L: Dick Drago (2-4) S: Mike Marshall (12) | First | -- |
| » Defeated Twins (41-53), 4-2 | Metropolitan Stadium (3-1) | 63-33 | |
| » W: Andy Hassler (2-4) L: Geoff Zahn (8-9) S: Bob Stanley (8) | First | -- |
| Tuesday, July 25 |
| » Lost to Twins (42-53), 5-2 | Metropolitan Stadium (3-2) | 63-34 | |
| » W: Roger Erickson (10-6) L: Bill Lee (10-5) S: Mike Marshall (13) | First | -- |
| Wednesday, July 26 |
| » Lost to Rangers (47-51), 2-0 | Arlington Stadium (0-4) | 63-35 | Lost 2 |
| » W: Doc Medich (5-5) L: Dennis Eckersley (11-4) | First | -- |
| Thursday, July 27 |
| » Lost to Rangers (48-51), 3-1 | Arlington Stadium (0-5) | 63-36 | Lost 3 |
| » W: Jon Matlack (8-8) L: Luis Tiant (7-3) | First | -- |
| Friday, July 28 |
| » Lost to Royals (57-42), 4-0 | Fenway Park (38-9) | 63-37 | Lost 4 |
| » W: Rich Gale (12-3) L: Mike Torrez (12-6) | First | -- |
| Saturday, July 29 |
| » Defeated Royals (57-43), 1-0 | Fenway Park (39-9) | 64-37 | |
| » W: Jim Wright (6-2) L: Dennis Leonard (12-12) | First | -- |
| Sunday, July 30 |
| » Lost to Royals (58-43), 2-1 | Fenway Park (39-10) | 64-38 | |
| » W: Paul Splittorff (12-9) L: Bill Lee (10-6) S: Al Hrabosky (14) | First | -- |
| Monday, July 31 |
| » Defeated White Sox (44-59), 9-2 | Fenway Park (40-10) | 65-38 | |
| » W: Dennis Eckersley (12-4) L: Ken Kravec (7-10) | First | -- |
| Tuesday, August 1 |
| » Lost to White Sox (45-59), 5-2 | Fenway Park (40-11) | 65-39 | |
| » W: Mike Proly (2-0) L: Luis Tiant (7-4) | First | -- |
| Wednesday, August 2 |
| » Defeated Yankees (59-47), 7-5 | Yankee Stadium (2-1) | 66-39 | |
| » W: Bob Stanley (6-1) L: Ken Clay (2-4) | First | -- |
| Thursday, August 3 |
| » Defeated Yankees (59-48), 8-1 | Yankee Stadium (3-1) | 67-39 | Won 2 |
| » W: Mike Torrez (13-6) L: Jim Beattie (2-6) | First | -- |
| Friday, August 4 |
| » Lost to Brewers (61-44), 6-2 | County Stadium (2-3) | 67-40 | |
| » W: Lary Sorensen (13-8) L: Bill Lee (10-7) | First | -- |
| Saturday, August 5 |
| » Defeated Brewers (61-45), 8-1 | County Stadium (3-3) | 68-40 | |
| » W: Dennis Eckersley (13-4) L: Eduardo Rodriguez (2-5) | First | -- |
| Sunday, August 6 |
| » Defeated Brewers (61-46), 4-0 | County Stadium (4-3) | 69-40 | Won 2 |
| » W: Luis Tiant (8-4) L: Bill Travers (7-6) | First | -- |
| Tuesday, August 8 |
| » Defeated Indians (51-58), 9-7 | Fenway Park (41-11) | 70-40 | Won 3 |
| » W: Bob Stanley (7-1) L: Dave Freisleben (1-6) | First | -- |
| Wednesday, August 9 |
| » Lost to Indians (52-58), 5-1 | Fenway Park (41-12) | 70-41 | |
| » W: Rick Wise (9-14) L: Bill Lee (10-8) S: Jim Kern (9) | First | -- |
| Thursday, August 10 |
| » Defeated Indians (52-59), 6-5 | Fenway Park (42-12) | 71-41 | |
| » W: Bob Stanley (8-1) L: Dan Spillner (3-1) | First | -- |
| Friday, August 11 |
| » Lost to Brewers (62-49), 10-5 | Fenway Park (42-13) | 71-42 | |
| » W: Eduardo Rodriguez (3-5) L: Luis Tiant (8-5) | First | -- |
| Saturday, August 12 |
| » Defeated Brewers (62-50), 3-1 | Fenway Park (43-13) | 72-42 | |
| » W: Jim Wright (7-2) L: Bill Travers (7-7) | First | -- |
| » Defeated Brewers (62-51), 11-4 | Fenway Park (44-13) | 73-42 | Won 2 |
| » W: Bob Stanley (9-1) L: Mike Caldwell (14-7) | First | -- |
| Sunday, August 13 |
| » Defeated Brewers (62-52), 4-3 | Fenway Park (45-13) | 74-42 | Won 3 |
| » W: Mike Torrez (14-6) L: Bill Castro (3-4) | First | -- |
| Monday, August 14 |
| » Lost to Brewers (63-52), 4-3 | Fenway Park (45-14) | 74-43 | |
| » W: Lary Sorensen (14-8) L: Bill Lee (10-9) S: Bob McClure (7) | First | -- |
| Tuesday, August 15 |
| » Lost to Angels (66-55), 5-2 | Anaheim Stadium (2-2) | 74-44 | Lost 2 |
| » W: Frank Tanana (16-7) L: Dennis Eckersley (13-5) | First | -- |
| Wednesday, August 16 |
| » Defeated Angels (66-56), 4-2 | Anaheim Stadium (3-2) | 75-44 | |
| » W: Luis Tiant (9-5) L: Nolan Ryan (6-11) | First | -- |
| Thursday, August 17 |
| » Defeated Angels (66-57), 8-6 | Anaheim Stadium (4-2) | 76-44 | Won 2 |
| » W: Bob Stanley (10-1) L: Tom Griffin (2-4) | First | -- |
| Friday, August 18 |
| » Defeated Athletics (61-63), 6-3 | Oakland-Alameda County Stadium (1-2) | 77-44 | Won 3 |
| » W: Mike Torrez (15-6) L: Steve Renko (6-8) S: Dick Drago (7) | First | -- |
| Saturday, August 19 |
| » Lost to Athletics (62-63), 8-4 | Oakland-Alameda County Stadium (1-3) | 77-45 | |
| » W: John Henry Johnson (10-6) L: Bill Lee (10-10) S: Bob Lacey (5) | First | -- |
| » Major-league debuts: Bruce Robinson (Athletics) |
| Sunday, August 20 |
| » Defeated Athletics (62-64), 4-2 | Oakland-Alameda County Stadium (2-3) | 78-45 | |
| » W: Dennis Eckersley (14-5) L: Matt Keough (7-11) | First | -- |
| Tuesday, August 22 |
| » Lost to Mariners (48-77), 5-2 | Kingdome (3-1) | 78-46 | |
| » W: Glenn Abbott (6-10) L: Luis Tiant (9-6) | First | -- |
| Wednesday, August 23 |
| » Lost to Mariners (49-77), 5-3 | Kingdome (3-2) | 78-47 | Lost 2 |
| » W: Byron McLaughlin (2-4) L: Mike Torrez (15-7) S: Enrique Romo (10) | First | -- |
| Friday, August 25 |
| » Defeated Angels (70-59), 6-0 | Fenway Park (46-14) | 79-47 | |
| » W: Dennis Eckersley (15-5) L: Don Aase (8-8) | First | -- |
| Saturday, August 26 |
| » Defeated Angels (70-60), 7-1 | Fenway Park (47-14) | 80-47 | Won 2 |
| » W: Jim Wright (8-2) L: Paul Hartzell (5-8) | First | -- |
| Sunday, August 27 |
| » Defeated Angels (70-61), 4-3 | Fenway Park (48-14) | 81-47 | Won 3 |
| » W: Bob Stanley (11-1) L: Dyar Miller (4-1) | First | -- |
| Monday, August 28 |
| » Defeated Mariners (49-81), 10-9 | Fenway Park (49-14) | 82-47 | Won 4 |
| » W: Bob Stanley (12-1) L: Enrique Romo (10-6) | First | -- |
| Tuesday, August 29 |
| » Defeated Mariners (49-82), 10-5 | Fenway Park (50-14) | 83-47 | Won 5 |
| » W: Dick Drago (3-4) L: Byron McLaughlin (2-5) S: Tom Burgmeier (4) | First | -- |
| Wednesday, August 30 |
| » Defeated Blue Jays (54-80), 2-1 | Fenway Park (51-14) | 84-47 | Won 6 |
| » W: Dennis Eckersley (16-5) L: Don Kirkwood (3-2) | First | -- |
| » Lost to Blue Jays (55-80), 7-6 | Fenway Park (51-15) | 84-48 | |
| » W: Victor Cruz (6-1) L: Bob Stanley (12-2) | First | -- |
| Friday, September 1 |
| » Lost to Athletics (63-72), 5-1 | Fenway Park (51-16) | 84-49 | Lost 2 |
| » W: Matt Keough (8-11) L: Luis Tiant (9-7) | First | -- |
| Saturday, September 2 |
| » Lost to Athletics (64-72), 4-3 | Fenway Park (51-17) | 84-50 | Lost 3 |
| » W: Rick Langford (7-10) L: Mike Torrez (15-8) S: Dave Heaverlo (10) | First | -- |
| Sunday, September 3 |
| » Defeated Athletics (64-73), 11-6 | Fenway Park (52-17) | 85-50 | |
| » W: Bob Stanley (13-2) L: Pete Broberg (9-11) | First | -- |
| Monday, September 4 |
| » Lost to Orioles (77-61), 5-3 | Memorial Stadium (2-4) | 85-51 | |
| » W: Scott McGregor (13-12) L: Dennis Eckersley (16-6) S: Don Stanhouse (20) | First | -- |
| Tuesday, September 5 |
| » Lost to Orioles (78-61), 4-1 | Memorial Stadium (2-5) | 85-52 | Lost 2 |
| » W: Jim Palmer (18-12) L: Bobby Sprowl (0-1) S: Don Stanhouse (21) | First | -- |
| Wednesday, September 6 |
| » Defeated Orioles (78-62), 2-0 | Memorial Stadium (3-5) | 86-52 | |
| » W: Luis Tiant (10-7) L: Dennis Martinez (12-11) | First | -- |
| Thursday, September 7 |
| » Lost to Yankees (83-56), 15-3 | Fenway Park (52-18) | 86-53 | |
| » W: Ken Clay (3-4) L: Mike Torrez (15-9) | First | -- |
| Friday, September 8 |
| » Lost to Yankees (84-56), 13-2 | Fenway Park (52-19) | 86-54 | Lost 2 |
| » W: Jim Beattie (4-7) L: Jim Wright (8-3) | First | -- |
| » Major-league debuts: Domingo Ramos (Yankees) |
| Saturday, September 9 |
| » Lost to Yankees (85-56), 7-0 | Fenway Park (52-20) | 86-55 | Lost 3 |
| » W: Ron Guidry (21-2) L: Dennis Eckersley (16-7) | First | -- |
| Sunday, September 10 |
| » Lost to Yankees (86-56), 7-4 | Fenway Park (52-21) | 86-56 | Lost 4 |
| » W: Ed Figueroa (16-9) L: Bobby Sprowl (0-2) S: Rich Gossage (23) | First | -- |
| Monday, September 11 |
| » Defeated Orioles (80-63), 5-4 | Fenway Park (53-21) | 87-56 | |
| » W: Bob Stanley (14-2) L: Joe Kerrigan (3-1) | First | -- |
| Tuesday, September 12 |
| » Lost to Orioles (81-63), 3-2 | Fenway Park (53-22) | 87-57 | |
| » W: Dennis Martinez (13-11) L: Mike Torrez (15-10) | First | -- |
| Wednesday, September 13 |
| » Lost to Indians (63-81), 2-1 | Cleveland Stadium (3-4) | 87-58 | Lost 2 |
| » W: David Clyde (7-10) L: Dennis Eckersley (16-8) S: Jim Kern (12) | Second | ½ out |
| Thursday, September 14 |
| » Lost to Indians (64-81), 4-3 | Cleveland Stadium (3-5) | 87-59 | Lost 3 |
| » W: Mike Paxton (11-9) L: Jim Wright (8-4) S: Jim Kern (13) | Second | 1½ out |
| Friday, September 15 |
| » Lost to Yankees (89-57), 4-0 | Yankee Stadium (3-2) | 87-60 | Lost 4 |
| » W: Ron Guidry (22-2) L: Luis Tiant (10-8) | Second | 2½ out |
| Saturday, September 16 |
| » Lost to Yankees (90-57), 3-2 | Yankee Stadium (3-3) | 87-61 | Lost 5 |
| » W: Catfish Hunter (10-5) L: Mike Torrez (15-11) | Second | 3½ out |
| Sunday, September 17 |
| » Defeated Yankees (90-58), 7-3 | Yankee Stadium (4-3) | 88-61 | |
| » W: Dennis Eckersley (17-8) L: Jim Beattie (5-8) S: Bob Stanley (9) | Second | 2½ out |
| Monday, September 18 |
| » Defeated Tigers (80-69), 5-4 | Tiger Stadium (3-2) | 89-61 | Won 2 |
| » W: Andy Hassler (3-4) L: Steve Baker (1-3) | Second | 2½ out |
| Tuesday, September 19 |
