| Monday, March 20 |
| Future Padre Mike Bynum is born in Tampa, FL. |
| Wednesday, April 5 |
| » Major-league debuts: Hosken Powell (Twins) |
| Friday, April 7 |
| » Defeated Giants (0-1), 3-2 | Candlestick Park (1-0) | 1-0 | |
| » W: Mickey Lolich (1-0) L: Gary Lavelle (0-1) S: Rollie Fingers (1) | Second | ½ out |
| » Major-league debuts: Don Reynolds and Ozzie Smith (Padres) |
| Saturday, April 8 |
| » Lost to Giants (1-1), 6-0 | Candlestick Park (1-1) | 1-1 | |
| » W: Jim Barr (1-0) L: Bob Shirley (0-1) | Third | 1½ out |
| » Major-league debuts: Rick Sweet (Padres) |
| Sunday, April 9 |
| » Lost to Giants (2-1), 7-5 | Candlestick Park (1-2) | 1-2 | Lost 2 |
| » W: Gary Lavelle (1-1) L: Rollie Fingers (0-1) S: Randy Moffitt (1) | Fourth | 2½ out |
| Monday, April 10 |
| » Lost to Braves (1-3), 8-7 | Atlanta-Fulton County Stadium (0-1) | 1-3 | Lost 3 |
| » W: Adrian Devine (1-0) L: Bob Shirley (0-2) | Third | 3 out |
| Tuesday, April 11 |
| » Defeated Braves (1-4), 3-2 | Atlanta-Fulton County Stadium (1-1) | 2-3 | |
| » W: Rollie Fingers (1-1) L: Phil Niekro (0-2) | Third | 2 out |
| Friday, April 14 |
| » Lost to Giants (4-3), 3-2 | San Diego/Jack Murphy Stadium (0-1) | 2-4 | |
| » W: Randy Moffitt (1-0) L: Rollie Fingers (1-2) | Fourth | 4 out |
| Sunday, April 16 |
| » Lost to Giants (5-3), 8-4 | San Diego/Jack Murphy Stadium (0-2) | 2-5 | Lost 2 |
| » W: Bob Knepper (1-0) L: Bob Owchinko (0-1) S: Gary Lavelle (1) | Fifth | 3½ out |
| Tuesday, April 18 |
| » Lost to Astros (5-6), 5-1 | San Diego/Jack Murphy Stadium (0-3) | 2-6 | Lost 3 |
| » W: Joe Niekro (1-1) L: Bob Shirley (0-3) | Fourth | 5 out |
| Wednesday, April 19 |
| » Lost to Astros (6-6), 2-1 | San Diego/Jack Murphy Stadium (0-4) | 2-7 | Lost 4 |
| » W: Joaquin Andujar (1-2) L: Dave Freisleben (0-1) S: Joe Sambito (1) | Sixth | 5 out |
| Thursday, April 20 |
| » Defeated Braves (3-8), 2-0 | San Diego/Jack Murphy Stadium (1-4) | 3-7 | |
| » W: Randy Jones (1-0) L: Phil Niekro (0-4) S: Rollie Fingers (2) | Fifth | 4½ out |
| Friday, April 21 |
| » Defeated Braves (3-9), 9-3 | San Diego/Jack Murphy Stadium (2-4) | 4-7 | Won 2 |
| » W: Gaylord Perry (1-0) L: Jamie Easterly (0-1) | Fifth | 3½ out |
| Saturday, April 22 |
| » Defeated Braves (3-10), 2-0 | San Diego/Jack Murphy Stadium (3-4) | 5-7 | Won 3 |
| » W: Bob Owchinko (1-1) L: Tommy Boggs (0-3) S: Rollie Fingers (3) | Fifth | 3½ out |
| Sunday, April 23 |
| » Defeated Braves (3-11), 5-4 | San Diego/Jack Murphy Stadium (4-4) | 6-7 | Won 4 |
| » W: Dave Wehrmeister (1-0) L: Eddie Solomon (0-1) | Fourth | 3½ out |
| » Major-league debuts: Mark Lee (Padres) |
| Monday, April 24 |
| » Lost to Astros (8-9), 4-3 | Astrodome (0-1) | 6-8 | |
| » W: Joe Sambito (2-0) L: Rollie Fingers (1-3) | Fifth | 4 out |
| Tuesday, April 25 |
| » Lost to Astros (9-9), 4-3 | Astrodome (0-2) | 6-9 | Lost 2 |
| » W: Mark Lemongello (2-2) L: Randy Jones (1-1) | Fifth | 4½ out |
| Wednesday, April 26 |
| » Defeated Astros (9-10), 2-1 | Astrodome (1-2) | 7-9 | |
| » W: Gaylord Perry (2-0) L: J.R. Richard (1-2) S: Rollie Fingers (4) | Fourth | 4½ out |
| Friday, April 28 |
| » Lost to Phillies (8-7), 3-2 | Veteran's Stadium (0-1) | 7-10 | |
| » W: Larry Christenson (2-1) L: Bob Owchinko (1-2) S: Ron Reed (1) | Fifth | 5½ out |
| Saturday, April 29 |
| » Lost to Phillies (9-7), 7-2 | Veteran's Stadium (0-2) | 7-11 | Lost 2 |
| » W: Jim Lonborg (2-2) L: Dave Freisleben (0-2) | Fifth | 5½ out |
| Sunday, April 30 |
| » Lost to Phillies (10-7), 11-4 | Veteran's Stadium (0-3) | 7-12 | Lost 3 |
| » W: Randy Lerch (3-1) L: Randy Jones (1-2) | Fifth | 5½ out |
| Monday, May 1 |
| » Lost to Pirates (11-9), 7-4 | Three Rivers Stadium (0-1) | 7-13 | Lost 4 |
| » W: Jim Bibby (3-1) L: Rollie Fingers (1-4) | Fifth | 6 out |
| Tuesday, May 2 |
| » Defeated Pirates (11-10), 2-1 | Three Rivers Stadium (1-1) | 8-13 | |
| » W: Bob Owchinko (2-2) L: John Candelaria (1-4) | Fifth | 5 out |
| Wednesday, May 3 |
| » Defeated Pirates (11-11), 7-5 | Three Rivers Stadium (2-1) | 9-13 | Won 2 |
| » W: John D'Acquisto (1-0) L: Jim Bibby (3-2) S: Rollie Fingers (5) | Fifth | 5 out |
| Friday, May 5 |
| » Defeated Cardinals (10-15), 2-1 | Busch Stadium II (1-0) | 10-13 | Won 3 |
| » W: Randy Jones (2-2) L: John Urrea (2-3) S: Rollie Fingers (6) | Fourth | 5½ out |
| Saturday, May 6 |
| » Lost to Cardinals (11-15), 1-0 | Busch Stadium II (1-1) | 10-14 | |
| » W: John Denny (3-1) L: Gaylord Perry (2-1) | Fourth | 5½ out |
| Sunday, May 7 |
| » Lost to Cardinals (12-15), 8-4 | Busch Stadium II (1-2) | 10-15 | Lost 2 |
| » W: Bob Forsch (5-2) L: Dave Freisleben (0-3) | Fourth | 5½ out |
| Tuesday, May 9 |
| » Lost to Cubs (13-13), 8-5 | San Diego/Jack Murphy Stadium (4-5) | 10-16 | Lost 3 |
| » W: Woodie Fryman (1-3) L: Bob Shirley (0-4) | Sixth | 6½ out |
| Wednesday, May 10 |
| » Defeated Cubs (13-14), 1-0 | San Diego/Jack Murphy Stadium (5-5) | 11-16 | |
| » W: Randy Jones (3-2) L: Dennis Lamp (1-4) | Fourth | 5½ out |
| Thursday, May 11 |
| » Lost to Cubs (14-14), 4-3 | San Diego/Jack Murphy Stadium (5-6) | 11-17 | |
| » W: Willie Hernandez (3-1) L: Mark Lee (0-1) S: Donnie Moore (3) | Fifth | 5½ out |
| Friday, May 12 |
| » Defeated Pirates (14-15), 6-4 | San Diego/Jack Murphy Stadium (6-6) | 12-17 | |
| » W: Mark Lee (1-1) L: Kent Tekulve (2-2) S: Rollie Fingers (7) | Fifth | 5 out |
| Saturday, May 13 |
| » Defeated Pirates (14-16), 6-5 | San Diego/Jack Murphy Stadium (7-6) | 13-17 | Won 2 |
| » W: Dan Spillner (1-0) L: Bruce Kison (1-2) S: Rollie Fingers (8) | Fifth | 5 out |
| Sunday, May 14 |
| » Lost to Pirates (15-16), 1-0 | San Diego/Jack Murphy Stadium (7-7) | 13-18 | |
| » W: Don Robinson (3-1) L: Randy Jones (3-3) | Fifth | 6½ out |
| Monday, May 15 |
| » Defeated Cardinals (14-21), 4-3 | San Diego/Jack Murphy Stadium (8-7) | 14-18 | |
| » W: Mark Lee (2-1) L: Pete Vuckovich (0-4) | Fourth | 6 out |
| Tuesday, May 16 |
| » Defeated Cardinals (14-22), 7-5 | San Diego/Jack Murphy Stadium (9-7) | 15-18 | Won 2 |
| » W: Bob Owchinko (3-2) L: John Urrea (2-5) S: John D'Acquisto (1) | Fourth | 6 out |
| Wednesday, May 17 |
| » Defeated Cardinals (14-23), 5-2 | San Diego/Jack Murphy Stadium (10-7) | 16-18 | Won 3 |
| » W: Bob Shirley (1-4) L: Eric Rasmussen (2-5) S: Rollie Fingers (9) | Fifth | 6 out |
| Friday, May 19 |
| » Lost to Reds (22-15), 4-3 | Riverfront Stadium (0-1) | 16-19 | |
| » W: Dave Tomlin (2-1) L: Rollie Fingers (1-5) S: Doug Bair (5) | Fifth | 7 out |
| Saturday, May 20 |
| » Lost to Reds (23-15), 10-6 | Riverfront Stadium (0-2) | 16-20 | Lost 2 |
| » W: Dave Tomlin (3-1) L: Rollie Fingers (1-6) | Fifth | 7 out |
| Sunday, May 21 |
| » Defeated Reds (23-16), 7-2 | Riverfront Stadium (1-2) | 17-20 | |
| » W: Bob Shirley (2-4) L: Manny Sarmiento (3-2) | Fifth | 6½ out |
| » Lost to Reds (24-16), 1-0 | Riverfront Stadium (1-3) | 17-21 | |
| » W: Tom Seaver (3-4) L: John D'Acquisto (1-1) S: Doug Bair (6) | Fifth | 6½ out |
| Monday, May 22 |
| » Lost to Dodgers (24-15), 8-1 | San Diego/Jack Murphy Stadium (10-8) | 17-22 | Lost 2 |
| » W: Don Sutton (4-4) L: Bob Owchinko (3-3) | Fifth | 7 out |
| Tuesday, May 23 |
| » Defeated Dodgers (24-16), 3-2 | San Diego/Jack Murphy Stadium (11-8) | 18-22 | |
| » W: Rollie Fingers (2-6) L: Tommy John (6-2) | Fifth | 7 out |
| Wednesday, May 24 |
| » Defeated Dodgers (24-17), 9-3 | San Diego/Jack Murphy Stadium (12-8) | 19-22 | Won 2 |
| » W: Gaylord Perry (3-1) L: Rick Rhoden (4-3) S: John D'Acquisto (2) | Fifth | 7 out |
| Friday, May 26 |
| » Lost to Reds (27-17), 3-1 | San Diego/Jack Murphy Stadium (12-9) | 19-23 | |
| » W: Tom Seaver (4-4) L: Bob Shirley (2-5) S: Doug Bair (7) | Fifth | 8½ out |
| Saturday, May 27 |
| » Lost to Reds (28-17), 5-2 | San Diego/Jack Murphy Stadium (12-10) | 19-24 | Lost 2 |
| » W: Bill Bonham (6-0) L: Bob Owchinko (3-4) | Fifth | 8½ out |
| Sunday, May 28 |
| » Defeated Reds (28-18), 3-1 | San Diego/Jack Murphy Stadium (13-10) | 20-24 | |
| » W: Randy Jones (4-3) L: Fred Norman (5-2) S: Rollie Fingers (10) | Fourth | 8½ out |
| Monday, May 29 |
| » Lost to Dodgers (26-19), 9-6 | Dodger Stadium (0-1) | 20-25 | |
| » W: Tommy John (7-2) L: Gaylord Perry (3-2) | Fourth | 9½ out |
| Tuesday, May 30 |
| » Lost to Dodgers (27-19), 10-2 | Dodger Stadium (0-2) | 20-26 | Lost 2 |
| » W: Rick Rhoden (5-3) L: Eric Rasmussen (2-6) | Fourth | 10½ out |
| Wednesday, May 31 |
| » Defeated Dodgers (27-20), 3-1 | Dodger Stadium (1-2) | 21-26 | |
| » W: Bob Shirley (3-5) L: Doug Rau (5-2) S: Rollie Fingers (11) | Fourth | 9½ out |
| Friday, June 2 |
| » Defeated Mets (23-28), 5-4 | Shea Stadium (1-0) | 22-26 | Won 2 |
| » W: Randy Jones (5-3) L: Nino Espinosa (5-3) S: Rollie Fingers (12) | Fourth | 9½ out |
| Saturday, June 3 |
| » Lost to Mets (24-28), 3-2 | Shea Stadium (1-1) | 22-27 | |
| » W: Pat Zachry (6-1) L: Bob Owchinko (3-5) S: Skip Lockwood (8) | Fifth | 9½ out |
| Sunday, June 4 |
| » Defeated Mets (24-29), 5-2 | Shea Stadium (2-1) | 23-27 | |
| » W: Gaylord Perry (4-2) L: Jerry Koosman (2-7) S: Rollie Fingers (13) | Fourth | 9½ out |
| Monday, June 5 |
| » Lost to Expos (27-24), 4-3 | Stade Olympique (0-1) | 23-28 | |
| » W: Rudy May (6-5) L: Eric Rasmussen (2-7) S: Mike Garman (3) | Fourth | 9½ out |
| Tuesday, June 6 |
| » Lost to Expos (28-24), 4-0 | Stade Olympique (0-2) | 23-29 | Lost 2 |
| » W: Wayne Twitchell (3-4) L: Bob Shirley (3-6) S: Bill Atkinson (2) | Fourth | 9½ out |
| Wednesday, June 7 |
| » Lost to Expos (29-24), 8-3 | Stade Olympique (0-3) | 23-30 | Lost 3 |
| » W: Ross Grimsley (10-2) L: Randy Jones (5-4) | Fourth | 10 out |
| Future Padre Donaldo Mendez is born in Barquisimeto, Venezuela. |
| Friday, June 9 |
| » Lost to Cubs (31-21), 5-0 | Wrigley Field (0-1) | 23-31 | Lost 4 |
| » W: Dennis Lamp (2-5) L: Bob Owchinko (3-6) | Fifth | 9½ out |
| Saturday, June 10 |
| » Defeated Cubs (31-22), 10-8 | Wrigley Field (1-1) | 24-31 | |
| » W: Gaylord Perry (5-2) L: Donnie Moore (4-2) S: Rollie Fingers (14) | Fifth | 9½ out |
| Sunday, June 11 |
| » Lost to Cubs (32-22), 7-4 | Wrigley Field (1-2) | 24-32 | |
| » W: Ray Burris (4-4) L: Bob Shirley (3-7) S: Bruce Sutter (8) | Fifth | 10½ out |
| Monday, June 12 |
| » Defeated Mets (27-33), 3-2 | San Diego/Jack Murphy Stadium (14-10) | 25-32 | |
| » W: Mark Lee (3-1) L: Pat Zachry (7-2) | Fifth | 10½ out |
| Tuesday, June 13 |
| » Lost to Mets (28-33), 3-2 | San Diego/Jack Murphy Stadium (14-11) | 25-33 | |
| » W: Skip Lockwood (7-4) L: Rollie Fingers (2-7) S: Paul Siebert (1) | Fifth | 11½ out |
| Wednesday, June 14 |
| » Defeated Expos (31-29), 6-2 | San Diego/Jack Murphy Stadium (15-11) | 26-33 | |
| » W: Eric Rasmussen (3-7) L: Wayne Twitchell (3-5) S: John D'Acquisto (3) | Fifth | 11 out |
| » Defeated Expos (31-30), 1-0 | San Diego/Jack Murphy Stadium (16-11) | 27-33 | Won 2 |
| » W: Gaylord Perry (6-2) L: Woodie Fryman (2-5) | Fifth | 11 out |
| Thursday, June 15 |
| » Lost to Expos (32-30), 3-1 | San Diego/Jack Murphy Stadium (16-12) | 27-34 | |
| » W: Ross Grimsley (11-3) L: Bob Shirley (3-8) | Fifth | 12 out |
| Friday, June 16 |
| » Lost to Phillies (31-26), 5-0 | San Diego/Jack Murphy Stadium (16-13) | 27-35 | Lost 2 |
| » W: Steve Carlton (7-6) L: Randy Jones (5-5) | Fifth | 13 out |
| Saturday, June 17 |
| » Defeated Phillies (31-27), 7-0 | San Diego/Jack Murphy Stadium (17-13) | 28-35 | |
| » W: Bob Owchinko (4-6) L: Jim Lonborg (5-5) | Fifth | 12 out |
| Sunday, June 18 |
| » Defeated Phillies (31-28), 4-1 | San Diego/Jack Murphy Stadium (18-13) | 29-35 | Won 2 |
| » W: Gaylord Perry (7-2) L: Dick Ruthven (2-7) S: Rollie Fingers (15) | Fifth | 12½ out |
| Tuesday, June 20 |
| » Lost to Braves (26-36), 5-3 | San Diego/Jack Murphy Stadium (18-14) | 29-36 | |
| » W: Phil Niekro (8-7) L: Randy Jones (5-6) S: Gene Garber (4) | Fifth | 12½ out |
| Wednesday, June 21 |
| » Lost to Braves (27-36), 2-0 | San Diego/Jack Murphy Stadium (18-15) | 29-37 | Lost 2 |
| » W: Adrian Devine (4-3) L: Bob Shirley (3-9) S: Gene Garber (5) | Fifth | 13½ out |
| Thursday, June 22 |
| » Defeated Braves (27-37), 2-0 | San Diego/Jack Murphy Stadium (19-15) | 30-37 | |
| » W: Bob Owchinko (5-6) L: Mickey Mahler (1-4) S: Rollie Fingers (16) | Fifth | 12½ out |
| Friday, June 23 |
| » Defeated Astros (30-34), 3-0 | San Diego/Jack Murphy Stadium (20-15) | 31-37 | Won 2 |
| » W: Gaylord Perry (8-2) L: Tom Dixon (3-3) | Fifth | 12½ out |
| Saturday, June 24 |
| » Defeated Astros (30-35), 6-5 | San Diego/Jack Murphy Stadium (21-15) | 32-37 | Won 3 |
| » W: Rollie Fingers (3-7) L: Ken Forsch (2-3) | Fourth | 12½ out |
| Sunday, June 25 |
| » Defeated Astros (30-36), 6-1 | San Diego/Jack Murphy Stadium (22-15) | 33-37 | Won 4 |
| » W: Bob Shirley (4-9) L: J.R. Richard (6-8) | Fourth | 11½ out |
| » Defeated Astros (30-37), 7-4 | San Diego/Jack Murphy Stadium (23-15) | 34-37 | Won 5 |
| » W: Eric Rasmussen (4-7) L: Bo McLaughlin (0-1) S: John D'Acquisto (4) | Fourth | 11½ out |
| Monday, June 26 |
| » Defeated Giants (45-26), 2-1 | San Diego/Jack Murphy Stadium (24-15) | 35-37 | Won 6 |
| » W: Rollie Fingers (4-7) L: Gary Lavelle (5-6) | Fourth | 10½ out |
| Tuesday, June 27 |
| » Lost to Giants (46-26), 9-1 | San Diego/Jack Murphy Stadium (24-16) | 35-38 | |
| » W: Vida Blue (11-4) L: Gaylord Perry (8-3) | Fourth | 11½ out |
| Wednesday, June 28 |
| » Lost to Giants (47-26), 4-2 | San Diego/Jack Murphy Stadium (24-17) | 35-39 | Lost 2 |
| » W: Jim Barr (4-4) L: Randy Jones (5-7) S: Randy Moffitt (5) | Fourth | 11½ out |
| » Defeated Giants (47-27), 4-1 | San Diego/Jack Murphy Stadium (25-17) | 36-39 | |
| » W: Eric Rasmussen (5-7) L: Charlie Williams (1-1) S: John D'Acquisto (5) | Fourth | 11½ out |
| Friday, June 30 |
| » Defeated Astros (33-39), 5-2 | Astrodome (2-2) | 37-39 | Won 2 |
| » W: Bob Shirley (5-9) L: J.R. Richard (6-9) S: Rollie Fingers (17) | Fourth | 10 out |
| Saturday, July 1 |
| » Lost to Astros (34-39), 9-2 | Astrodome (2-3) | 37-40 | |
| » W: Mark Lemongello (7-7) L: Bob Owchinko (5-7) | Fourth | 10½ out |
| » Defeated Astros (34-40), 9-3 | Astrodome (3-3) | 38-40 | |
| » W: Mark Wiley (1-0) L: Joe Niekro (5-5) S: John D'Acquisto (6) | Fourth | 10½ out |
| Sunday, July 2 |
| » Defeated Astros (34-41), 6-2 | Astrodome (4-3) | 39-40 | Won 2 |
| » W: Gaylord Perry (9-3) L: Tom Dixon (4-4) S: Rollie Fingers (18) | Fourth | 9½ out |
| Monday, July 3 |
| » Defeated Giants (48-31), 4-3 | Candlestick Park (2-2) | 40-40 | Won 3 |
| » W: Randy Jones (6-7) L: Jim Barr (4-5) S: Rollie Fingers (19) | Fourth | 8½ out |
| Tuesday, July 4 |
| » Defeated Giants (48-32), 7-5 | Candlestick Park (3-2) | 41-40 | Won 4 |
| » W: Eric Rasmussen (6-7) L: John Montefusco (7-3) S: John D'Acquisto (7) | Fourth | 7½ out |
| Wednesday, July 5 |
| » Lost to Giants (49-32), 5-4 | Candlestick Park (3-3) | 41-41 | |
| » W: John Curtis (2-1) L: Rollie Fingers (4-8) | Fourth | 8½ out |
| Thursday, July 6 |
| » Lost to Giants (50-32), 5-4 | Candlestick Park (3-4) | 41-42 | Lost 2 |
| » W: Bob Knepper (10-5) L: Randy Jones (6-8) S: Randy Moffitt (6) | Third | 9½ out |
| Friday, July 7 |
| » Lost to Braves (35-46), 11-3 | Atlanta-Fulton County Stadium (1-2) | 41-43 | Lost 3 |
| » W: Mickey Mahler (3-4) L: Gaylord Perry (9-4) | Fourth | 10 out |
| Saturday, July 8 |
| » Lost to Braves (36-46), 6-4 | Atlanta-Fulton County Stadium (1-3) | 41-44 | Lost 4 |
| » W: Craig Skok (2-1) L: John D'Acquisto (1-2) S: Gene Garber (10) | Fourth | 10½ out |
| » Defeated Braves (36-47), 7-0 | Atlanta-Fulton County Stadium (2-3) | 42-44 | |
| » W: Eric Rasmussen (7-7) L: Jamie Easterly (2-5) | Fourth | 10½ out |
| Sunday, July 9 |
| » Lost to Braves (37-47), 5-2 | Atlanta-Fulton County Stadium (2-4) | 42-45 | |
| » W: Preston Hanna (7-5) L: Bob Shirley (5-10) S: Gene Garber (11) | Fourth | 10½ out |
| Thursday, July 13 |
| » Defeated Cubs (43-40), 5-2 | Wrigley Field (2-2) | 43-45 | |
| » W: Gaylord Perry (10-4) L: Rick Reuschel (8-6) S: John D'Acquisto (8) | Fourth | 10½ out |
| Friday, July 14 |
| » Defeated Cubs (43-41), 9-5 | Wrigley Field (3-2) | 44-45 | Won 2 |
| » W: Eric Rasmussen (8-7) L: Dave Roberts (4-4) S: Rollie Fingers (20) | Third | 9½ out |
| Saturday, July 15 |
| » Lost to Cubs (44-41), 3-1 | Wrigley Field (3-3) | 44-46 | |
| » W: Bruce Sutter (6-3) L: John D'Acquisto (1-3) | Third | 10½ out |
| Sunday, July 16 |
| » Lost to Pirates (42-43), 3-2 | Three Rivers Stadium (2-2) | 44-47 | Lost 2 |
| » W: Ed Whitson (3-3) L: Rollie Fingers (4-9) | Fourth | 11½ out |
| » Lost to Pirates (43-43), 10-6 | Three Rivers Stadium (2-3) | 44-48 | Lost 3 |
| » W: Grant Jackson (4-3) L: Dennis Kinney (0-3) S: Kent Tekulve (15) | Fourth | 11½ out |
| Monday, July 17 |
| » Lost to Pirates (44-43), 8-7 | Three Rivers Stadium (2-4) | 44-49 | Lost 4 |
| » W: Kent Tekulve (5-5) L: Rollie Fingers (4-10) | Fourth | 12½ out |
| Tuesday, July 18 |
| » Defeated Cardinals (37-57), 3-2 | Busch Stadium II (2-2) | 45-49 | |
| » W: Eric Rasmussen (9-7) L: Pete Vuckovich (7-7) | Fourth | 11½ out |
| Wednesday, July 19 |
| » Defeated Cardinals (37-58), 5-3 | Busch Stadium II (3-2) | 46-49 | Won 2 |
| » W: Randy Jones (7-8) L: Roy Thomas (1-1) S: Bob Shirley (1) | Fourth | 11 out |
| Future Padre Steve Watkins is born in Lubbock, TX. |
| Thursday, July 20 |
| » Lost to Cardinals (38-58), 3-2 | Busch Stadium II (3-3) | 46-50 | |
| » W: Buddy Schultz (2-3) L: Rollie Fingers (4-11) S: Mark Littell (4) | Fourth | 12 out |
| Friday, July 21 |
| » Lost to Cubs (48-45), 5-4 | San Diego/Jack Murphy Stadium (25-18) | 46-51 | Lost 2 |
| » W: Rick Reuschel (9-7) L: Bob Shirley (5-11) S: Bruce Sutter (17) | Fourth | 12 out |
| Saturday, July 22 |
| » Defeated Cubs (48-46), 4-2 | San Diego/Jack Murphy Stadium (26-18) | 47-51 | |
| » W: John D'Acquisto (2-3) L: Ray Burris (5-9) | Fourth | 12 out |
| Sunday, July 23 |
| » Lost to Cubs (49-46), 4-3 | San Diego/Jack Murphy Stadium (26-19) | 47-52 | |
| » W: Dennis Lamp (3-10) L: Randy Jones (7-9) | Fourth | 13 out |
| Tuesday, July 25 |
| » Defeated Pirates (47-47), 2-1 | San Diego/Jack Murphy Stadium (27-19) | 48-52 | |
| » W: Bob Owchinko (6-7) L: Jim Rooker (5-7) | Fourth | 13 out |
| Wednesday, July 26 |
| » Defeated Pirates (47-48), 6-5 | San Diego/Jack Murphy Stadium (28-19) | 49-52 | Won 2 |
| » W: Gaylord Perry (11-4) L: Bruce Kison (2-3) S: Rollie Fingers (21) | Fourth | 12 out |
| Thursday, July 27 |
| » Defeated Pirates (47-49), 6-3 | San Diego/Jack Murphy Stadium (29-19) | 50-52 | Won 3 |
| » W: Bob Shirley (6-11) L: Ed Whitson (3-4) S: Rollie Fingers (22) | Fourth | 11½ out |
| Friday, July 28 |
| » Defeated Cardinals (40-62), 8-3 | San Diego/Jack Murphy Stadium (30-19) | 51-52 | Won 4 |
| » W: Randy Jones (8-9) L: John Denny (8-8) | Fourth | 10½ out |
| Saturday, July 29 |
| » Defeated Cardinals (40-63), 7-3 | San Diego/Jack Murphy Stadium (31-19) | 52-52 | Won 5 |
| » W: Bob Owchinko (7-7) L: Pete Vuckovich (8-8) | Third | 9½ out |
| Sunday, July 30 |
| » Defeated Cardinals (40-64), 3-2 | San Diego/Jack Murphy Stadium (32-19) | 53-52 | Won 6 |
| » W: Gaylord Perry (12-4) L: Bob Forsch (9-11) S: Rollie Fingers (23) | Third | 10 out |
| Monday, July 31 |
| » Defeated Dodgers (61-44), 4-3 | San Diego/Jack Murphy Stadium (33-19) | 54-52 | Won 7 |
| » W: Eric Rasmussen (10-7) L: Rick Rhoden (8-6) S: Rollie Fingers (24) | Fourth | 9 out |
| Tuesday, August 1 |
| » Defeated Dodgers (61-45), 1-0 | San Diego/Jack Murphy Stadium (34-19) | 55-52 | Won 8 |
| » W: Randy Jones (9-9) L: Burt Hooton (11-8) | Fourth | 8 out |
| Wednesday, August 2 |
| » Defeated Dodgers (61-46), 2-1 | San Diego/Jack Murphy Stadium (35-19) | 56-52 | Won 9 |
| » W: Bob Owchinko (8-7) L: Tommy John (12-8) S: Rollie Fingers (25) | Fourth | 8 out |
| Friday, August 4 |
| » Defeated Reds (63-45), 3-2 | Riverfront Stadium (2-3) | 57-52 | Won 10 |
| » W: Bob Shirley (7-11) L: Doug Bair (4-4) S: Rollie Fingers (26) | Fourth | 8½ out |
| Future Padre Jon Knott is born in Manassas, VA. |
| Saturday, August 5 |
| » Lost to Reds (64-45), 7-1 | Riverfront Stadium (2-4) | 57-53 | |
| » W: Mike LaCoss (3-1) L: Eric Rasmussen (10-8) | Fourth | 8½ out |
| Sunday, August 6 |
| » Lost to Reds (65-45), 3-1 | Riverfront Stadium (2-5) | 57-54 | Lost 2 |
| » W: Fred Norman (10-6) L: Randy Jones (9-10) S: Doug Bair (21) | Fourth | 8½ out |
| Monday, August 7 |
| » Lost to Dodgers (64-48), 3-1 | Dodger Stadium (1-3) | 57-55 | Lost 3 |
| » W: Tommy John (13-8) L: Bob Owchinko (8-8) | Fourth | 9 out |
| Tuesday, August 8 |
| » Lost to Dodgers (65-48), 3-2 | Dodger Stadium (1-4) | 57-56 | Lost 4 |
| » W: Don Sutton (12-9) L: Gaylord Perry (12-5) | Fourth | 10 out |
| Wednesday, August 9 |
| » Lost to Dodgers (66-48), 3-0 | Dodger Stadium (1-5) | 57-57 | Lost 5 |
| » W: Doug Rau (11-7) L: Eric Rasmussen (10-9) | Fourth | 10 out |
| Thursday, August 10 |
| » Defeated Reds (66-48), 15-3 | San Diego/Jack Murphy Stadium (36-19) | 58-57 | |
| » W: Randy Jones (10-10) L: Mike LaCoss (3-2) S: Bob Shirley (2) | Third | 9 out |
| Friday, August 11 |
| » Lost to Reds (67-48), 2-0 | San Diego/Jack Murphy Stadium (36-20) | 58-58 | |
| » W: Doug Bair (5-4) L: Bob Owchinko (8-9) | Fourth | 10 out |
| Saturday, August 12 |
| » Defeated Reds (67-49), 4-2 | San Diego/Jack Murphy Stadium (37-20) | 59-58 | |
| » W: Gaylord Perry (13-5) L: Tom Seaver (11-11) S: Rollie Fingers (27) | Third | 9 out |
| Sunday, August 13 |
| » Defeated Reds (67-50), 3-2 | San Diego/Jack Murphy Stadium (38-20) | 60-58 | Won 2 |
| » W: Eric Rasmussen (11-9) L: Fred Norman (10-7) S: Bob Shirley (3) | Fourth | 9 out |
| Tuesday, August 15 |
| » Lost to Mets (49-69), 3-1 | Shea Stadium (2-2) | 60-59 | |
| » W: Craig Swan (6-5) L: Randy Jones (10-11) S: Skip Lockwood (14) | Third | 9 out |
| Wednesday, August 16 |
| » Defeated Mets (49-70), 2-1 | Shea Stadium (3-2) | 61-59 | |
| » W: John D'Acquisto (3-3) L: Skip Lockwood (7-10) | Fourth | 9 out |
| Thursday, August 17 |
| » Defeated Mets (49-71), 9-2 | Shea Stadium (4-2) | 62-59 | Won 2 |
| » W: Gaylord Perry (14-5) L: Juan Berenguer (0-1) S: Mickey Lolich (1) | Fourth | 9 out |
| » Major-league debuts: Juan Berenguer (Mets) |
| Friday, August 18 |
| » Defeated Expos (58-64), 3-2 | Stade Olympique (1-3) | 63-59 | Won 3 |
| » W: Eric Rasmussen (12-9) L: Steve Rogers (13-8) S: Mark Lee (1) | Fourth | 9 out |
| Saturday, August 19 |
| » Defeated Expos (58-65), 3-2 | Stade Olympique (2-3) | 64-59 | Won 4 |
| » W: Randy Jones (11-11) L: Dan Schatzeder (5-4) S: Rollie Fingers (28) | Fourth | 8 out |
| Sunday, August 20 |
| » Defeated Expos (58-66), 5-4 | Stade Olympique (3-3) | 65-59 | Won 5 |
| » W: Mark Lee (4-1) L: Hal Dues (5-5) S: Rollie Fingers (29) | Fourth | 8 out |
| Monday, August 21 |
| » Defeated Phillies (65-56), 7-3 | Veteran's Stadium (1-3) | 66-59 | Won 6 |
| » W: Gaylord Perry (15-5) L: Warren Brusstar (3-1) S: Bob Shirley (4) | Fourth | 7 out |
| Tuesday, August 22 |
| » Lost to Phillies (66-56), 5-3 | Veteran's Stadium (1-4) | 66-60 | |
| » W: Larry Christenson (9-12) L: Eric Rasmussen (12-10) S: Ron Reed (11) | Fourth | 7½ out |
| Wednesday, August 23 |
| » Defeated Phillies (66-57), 6-5 | Veteran's Stadium (2-4) | 67-60 | |
| » W: Rollie Fingers (5-11) L: Ron Reed (1-1) | Fourth | 7½ out |
| Thursday, August 24 |
| » Lost to Mets (51-76), 6-3 | San Diego/Jack Murphy Stadium (38-21) | 67-61 | |
| » W: Mike Bruhert (3-6) L: Bob Owchinko (8-10) | Fourth | 8½ out |
| Friday, August 25 |
| » Lost to Mets (52-76), 2-1 | San Diego/Jack Murphy Stadium (38-22) | 67-62 | Lost 2 |
| » W: Craig Swan (7-5) L: Gaylord Perry (15-6) | Fourth | 9½ out |
| Saturday, August 26 |
| » Defeated Mets (52-77), 2-1 | San Diego/Jack Murphy Stadium (39-22) | 68-62 | |
| » W: Mickey Lolich (2-0) L: Jerry Koosman (3-14) S: Rollie Fingers (30) | Fourth | 8½ out |
| Sunday, August 27 |
| » Defeated Mets (52-78), 3-0 | San Diego/Jack Murphy Stadium (40-22) | 69-62 | Won 2 |
| » W: Eric Rasmussen (13-10) L: Nino Espinosa (9-13) | Fourth | 7½ out |
| Monday, August 28 |
| » Lost to Phillies (69-59), 6-1 | San Diego/Jack Murphy Stadium (40-23) | 69-63 | |
| » W: Jim Kaat (7-5) L: Randy Jones (11-12) | Fourth | 8½ out |
| Tuesday, August 29 |
| » Lost to Phillies (70-59), 9-5 | San Diego/Jack Murphy Stadium (40-24) | 69-64 | Lost 2 |
| » W: Dick Ruthven (12-9) L: Bob Owchinko (8-11) | Fourth | 9½ out |
| Wednesday, August 30 |
| » Lost to Phillies (71-59), 6-5 | San Diego/Jack Murphy Stadium (40-25) | 69-65 | Lost 3 |
| » W: Warren Brusstar (4-2) L: Rollie Fingers (5-12) | Fourth | 10½ out |
| Thursday, August 31 |
| » Defeated Expos (61-73), 6-1 | San Diego/Jack Murphy Stadium (41-25) | 70-65 | |
| » W: Eric Rasmussen (14-10) L: Woodie Fryman (7-9) S: Mark Lee (2) | Fourth | 10 out |
| Friday, September 1 |
| » Lost to Expos (62-73), 3-2 | San Diego/Jack Murphy Stadium (41-26) | 70-66 | |
| » W: Mike Garman (3-6) L: Randy Jones (11-13) | Fourth | 11 out |
| Saturday, September 2 |
| » Lost to Expos (63-73), 3-2 | San Diego/Jack Murphy Stadium (41-27) | 70-67 | Lost 2 |
| » W: Scott Sanderson (1-2) L: Mickey Lolich (2-1) S: Mike Garman (10) | Fourth | 11½ out |
| Monday, September 4 |
| » Defeated Braves (59-78), 8-4 | Atlanta-Fulton County Stadium (3-4) | 71-67 | |
| » W: Gaylord Perry (16-6) L: Larry McWilliams (7-1) S: John D'Acquisto (9) | Fourth | 11 out |
| » Major-league debuts: Barry Evans (Padres) |
| Tuesday, September 5 |
| » Lost to Braves (60-78), 8-1 | Atlanta-Fulton County Stadium (3-5) | 71-68 | |
| » W: Phil Niekro (17-15) L: Eric Rasmussen (14-11) | Fourth | 11½ out |
| » Major-league debuts: Steve Mura (Padres) |
| Wednesday, September 6 |
| » Defeated Braves (60-79), 5-3 | Atlanta-Fulton County Stadium (4-5) | 72-68 | |
| » W: Mark Lee (5-1) L: Gene Garber (3-5) S: Rollie Fingers (31) | Fourth | 11½ out |
| Thursday, September 7 |
| » Lost to Reds (76-63), 6-2 | Riverfront Stadium (2-6) | 72-69 | |
| » W: Paul Moskau (5-4) L: Bob Owchinko (8-12) S: Fred Norman (1) | Fourth | 12½ out |
| » Major-league debuts: Juan Eichelberger (Padres) |
| Friday, September 8 |
| » Defeated Reds (76-64), 3-2 | Riverfront Stadium (3-6) | 73-69 | |
| » W: Gaylord Perry (17-6) L: Mike LaCoss (3-7) S: Rollie Fingers (32) | Fourth | 11½ out |
| Saturday, September 9 |
| » Lost to Astros (66-75), 10-4 | Astrodome (4-4) | 73-70 | |
| » W: Joe Niekro (12-12) L: Steve Mura (0-1) | Fourth | 11½ out |
| Sunday, September 10 |
| » Lost to Astros (67-75), 3-2 | Astrodome (4-5) | 73-71 | Lost 2 |
| » W: J.R. Richard (16-11) L: Eric Rasmussen (14-12) | Fourth | 12½ out |
| Monday, September 11 |
| » Lost to Braves (63-81), 7-2 | San Diego/Jack Murphy Stadium (41-28) | 73-72 | Lost 3 |
| » W: Larry McWilliams (8-1) L: Randy Jones (11-14) | Fourth | 13½ out |
| Future Padre Junior Herndon is born in Liberal, KS. |
| Tuesday, September 12 |
| » Defeated Braves (63-82), 3-1 | San Diego/Jack Murphy Stadium (42-28) | 74-72 | |
| » W: Gaylord Perry (18-6) L: Mickey Mahler (4-11) | Fourth | 13½ out |
| Wednesday, September 13 |
| » Defeated Reds (80-65), 6-2 | San Diego/Jack Murphy Stadium (43-28) | 75-72 | Won 2 |
| » W: Bob Owchinko (9-12) L: Manny Sarmiento (9-7) S: Rollie Fingers (33) | Fourth | 13½ out |
| Thursday, September 14 |
| » Defeated Reds (80-66), 8-1 | San Diego/Jack Murphy Stadium (44-28) | 76-72 | Won 3 |
| » W: Bob Shirley (8-11) L: Bill Bonham (11-5) S: John D'Acquisto (10) | Fourth | 13½ out |
| Friday, September 15 |
| » Lost to Astros (68-79), 8-4 | San Diego/Jack Murphy Stadium (44-29) | 76-73 | |
| » W: J.R. Richard (17-11) L: Eric Rasmussen (14-13) | Fourth | 14½ out |
| Saturday, September 16 |
| » Defeated Astros (68-80), 2-1 | San Diego/Jack Murphy Stadium (45-29) | 77-73 | |
| » W: Gaylord Perry (19-6) L: Joe Sambito (4-9) | Fourth | 14½ out |
| Sunday, September 17 |
| » Defeated Astros (68-81), 3-1 | San Diego/Jack Murphy Stadium (46-29) | 78-73 | Won 2 |
| » W: Randy Jones (12-14) L: Mark Lemongello (9-14) S: Rollie Fingers (34) | Fourth | 13½ out |
| Tuesday, September 19 |
| » Defeated Giants (82-69), 4-1 | San Diego/Jack Murphy Stadium (47-29) | 79-73 | Won 3 |
| » W: Bob Owchinko (10-12) L: Ed Halicki (8-10) S: Rollie Fingers (35) | Fourth | 13 out |
| Wednesday, September 20 |
|