| Wednesday, January 18 |
| Future Oriole Brian Falkenborg is born in Newport Beach, CA. |
| Thursday, March 30 |
| Former Oriole Billy Cox dies in Harrisburg, PA at the age of 59. |
| Wednesday, April 5 |
| » Major-league debuts: Hosken Powell (Twins) |
| Friday, April 7 |
| » Lost to Brewers (1-0), 11-3 | County Stadium (0-1) | 0-1 | |
| » W: Jerry Augustine (1-0) L: Mike Flanagan (0-1) | Third | 1 out |
| » Major-league debuts: Paul Molitor (Brewers) |
| Saturday, April 8 |
| » Lost to Brewers (2-0), 16-3 | County Stadium (0-2) | 0-2 | Lost 2 |
| » W: Moose Haas (1-0) L: Dennis Martinez (0-1) | Fifth | 2 out |
| Sunday, April 9 |
| » Lost to Brewers (3-0), 13-5 | County Stadium (0-3) | 0-3 | Lost 3 |
| » W: Lary Sorensen (1-0) L: Scott McGregor (0-1) | Fifth | 3 out |
| Monday, April 10 |
| » Lost to Royals (2-1), 4-2 | Royals Stadium (0-1) | 0-4 | Lost 4 |
| » W: Paul Splittorff (1-0) L: Nelson Briles (0-1) S: Al Hrabosky (1) | Fifth | 3½ out |
| Tuesday, April 11 |
| » Major-league debuts: Andy Replogle (Brewers) |
| Wednesday, April 12 |
| » Lost to Royals (3-1), 5-2 | Royals Stadium (0-2) | 0-5 | Lost 5 |
| » W: Dennis Leonard (1-1) L: Mike Flanagan (0-2) S: Steve Mingori (2) | Sixth | 5 out |
| Friday, April 14 |
| » Defeated Brewers (5-1), 6-5 | Memorial Stadium (1-0) | 1-5 | |
| » W: Dennis Martinez (1-1) L: Lary Sorensen (1-1) S: Don Stanhouse (1) | Sixth | 4 out |
| Saturday, April 15 |
| » Defeated Brewers (5-2), 7-0 | Memorial Stadium (2-0) | 2-5 | Won 2 |
| » W: Jim Palmer (1-0) L: Jerry Augustine (2-1) | Fifth | 3 out |
| Sunday, April 16 |
| » Defeated Brewers (5-3), 7-5 | Memorial Stadium (3-0) | 3-5 | Won 3 |
| » W: Nelson Briles (1-1) L: Moose Haas (2-1) S: Don Stanhouse (2) | Fifth | 3½ out |
| » Lost to Brewers (6-3), 9-2 | Memorial Stadium (3-1) | 3-6 | |
| » W: Andy Replogle (1-0) L: Scott McGregor (0-2) S: Eduardo Rodriguez (1) | Fifth | 3½ out |
| Monday, April 17 |
| » Defeated Yankees (4-5), 6-1 | Yankee Stadium (1-0) | 4-6 | |
| » W: Mike Flanagan (1-2) L: Catfish Hunter (0-2) | Fifth | 3½ out |
| Tuesday, April 18 |
| » Lost to Yankees (5-5), 4-3 | Yankee Stadium (1-1) | 4-7 | |
| » W: Sparky Lyle (1-0) L: Tippy Martinez (0-1) | Sixth | 4 out |
| Friday, April 21 |
| » Defeated Royals (8-2), 2-1 | Memorial Stadium (4-1) | 5-7 | |
| » W: Jim Palmer (2-0) L: Dennis Leonard (2-2) S: Don Stanhouse (3) | Fourth | 3½ out |
| Saturday, April 22 |
| » Lost to Royals (9-2), 5-3 | Memorial Stadium (4-2) | 5-8 | |
| » W: Paul Splittorff (4-0) L: Mike Flanagan (1-3) S: Al Hrabosky (4) | Sixth | 4½ out |
| Sunday, April 23 |
| » Lost to Royals (10-2), 6-5 | Memorial Stadium (4-3) | 5-9 | Lost 2 |
| » W: Larry Gura (2-0) L: Tim Stoddard (0-1) S: Marty Pattin (1) | Sixth | 5 out |
| Monday, April 24 |
| » Lost to Yankees (7-8), 8-2 | Memorial Stadium (4-4) | 5-10 | Lost 3 |
| » W: Ron Guidry (2-0) L: Scott McGregor (0-3) | Sixth | 6 out |
| Tuesday, April 25 |
| » Lost to Yankees (8-8), 4-3 | Memorial Stadium (4-5) | 5-11 | Lost 4 |
| » W: Jim Beattie (1-0) L: Jim Palmer (2-1) S: Sparky Lyle (2) | Fifth | 7 out |
| » Major-league debuts: Jim Beattie (Yankees) |
| Friday, April 28 |
| » Defeated White Sox (6-10), 6-4 | Comiskey Park I (1-0) | 6-11 | |
| » W: Dennis Martinez (2-1) L: Pablo Torrealba (1-2) S: Don Stanhouse (4) | Seventh | 6½ out |
| Saturday, April 29 |
| » Defeated White Sox (6-11), 5-2 | Comiskey Park I (2-0) | 7-11 | Won 2 |
| » W: Jim Palmer (3-1) L: Ken Kravec (1-3) S: Don Stanhouse (5) | Sixth | 6½ out |
| Sunday, April 30 |
| » Defeated White Sox (6-12), 8-7 | Comiskey Park I (3-0) | 8-11 | Won 3 |
| » W: Scott McGregor (1-3) L: Pablo Torrealba (1-3) | Fifth | 5½ out |
| Monday, May 1 |
| » Lost to Red Sox (12-9), 9-6 | Fenway Park (0-1) | 8-12 | |
| » W: Mike Torrez (3-1) L: Nelson Briles (1-2) S: Bob Stanley (1) | Sixth | 6 out |
| Tuesday, May 2 |
| » Defeated Red Sox (12-10), 3-1 | Fenway Park (1-1) | 9-12 | |
| » W: Dennis Martinez (3-1) L: Allen Ripley (0-2) | Fifth | 6 out |
| Wednesday, May 3 |
| » Lost to Rangers (10-10), 2-1 | Memorial Stadium (4-6) | 9-13 | |
| » W: Doyle Alexander (2-1) L: Don Stanhouse (0-1) | Sixth | 7 out |
| Friday, May 5 |
| » Defeated Twins (8-19), 2-1 | Memorial Stadium (5-6) | 10-13 | |
| » W: Mike Flanagan (2-3) L: Geoff Zahn (2-1) | Sixth | 6 out |
| Saturday, May 6 |
| » Lost to Twins (9-19), 8-7 | Memorial Stadium (5-7) | 10-14 | |
| » W: Greg Thayer (1-1) L: Don Stanhouse (0-2) S: Tom Johnson (2) | Sixth | 7 out |
| Sunday, May 7 |
| » Lost to Twins (10-19), 15-9 | Memorial Stadium (5-8) | 10-15 | Lost 2 |
| » W: Mac Scarce (1-1) L: Jim Palmer (3-2) | Sixth | 8 out |
| Wednesday, May 10 |
| » Defeated Red Sox (19-11), 3-2 | Memorial Stadium (6-8) | 11-15 | |
| » W: Mike Flanagan (3-3) L: Tom Burgmeier (1-1) | Sixth | 7 out |
| Thursday, May 11 |
| » Lost to Red Sox (20-11), 5-4 | Memorial Stadium (6-9) | 11-16 | |
| » W: Bill Lee (5-0) L: Dennis Martinez (3-2) S: Dick Drago (3) | Sixth | 7½ out |
| Friday, May 12 |
| » Lost to Rangers (14-12), 9-3 | Arlington Stadium (0-1) | 11-17 | Lost 2 |
| » W: Jon Matlack (3-4) L: Jim Palmer (3-3) | Sixth | 7½ out |
| Saturday, May 13 |
| » Defeated Rangers (14-13), 5-1 | Arlington Stadium (1-1) | 12-17 | |
| » W: Scott McGregor (2-3) L: Jim Umbarger (1-2) | Sixth | 7½ out |
| Sunday, May 14 |
| » Defeated Rangers (14-14), 3-2 | Arlington Stadium (2-1) | 13-17 | Won 2 |
| » W: John Flinn (1-0) L: Dock Ellis (2-2) S: Don Stanhouse (6) | Sixth | 7½ out |
| Monday, May 15 |
| » Lost to Twins (11-23), 9-6 | Metropolitan Stadium (0-1) | 13-18 | |
| » W: Mike Marshall (1-0) L: John Flinn (1-1) | Sixth | 7½ out |
| Tuesday, May 16 |
| » Lost to Twins (12-23), 8-1 | Metropolitan Stadium (0-2) | 13-19 | Lost 2 |
| » W: Dave Goltz (1-3) L: Jim Palmer (3-4) S: Tom Johnson (3) | Sixth | 8½ out |
| Thursday, May 18 |
| » Defeated Blue Jays (13-20), 5-3 | Memorial Stadium (7-9) | 14-19 | |
| » W: Mike Flanagan (4-3) L: Jim Clancy (2-3) | Sixth | 8 out |
| Friday, May 19 |
| » Lost to Indians (17-17), 7-5 | Cleveland Stadium (0-1) | 14-20 | |
| » W: Jim Kern (4-1) L: Don Stanhouse (0-3) | Sixth | 9 out |
| Saturday, May 20 |
| » Defeated Indians (17-18), 2-1 | Cleveland Stadium (1-1) | 15-20 | |
| » W: Jim Palmer (4-4) L: Rick Wise (2-7) S: Don Stanhouse (7) | Sixth | 8 out |
| Sunday, May 21 |
| » Defeated Indians (17-19), 3-0 | Cleveland Stadium (2-1) | 16-20 | Won 2 |
| » W: Scott McGregor (3-3) L: Rick Waits (3-3) | Fifth | 8 out |
| » Lost to Indians (18-19), 3-2 | Cleveland Stadium (2-2) | 16-21 | |
| » W: David Clyde (2-0) L: Nelson Briles (1-3) S: Dennis Kinney (5) | Fifth | 8 out |
| Tuesday, May 23 |
| » Defeated Tigers (23-13), 2-0 | Memorial Stadium (8-9) | 17-21 | |
| » W: Mike Flanagan (5-3) L: Jack Billingham (4-2) | Sixth | 7 out |
| Wednesday, May 24 |
| » Lost to Tigers (24-13), 3-2 | Memorial Stadium (8-10) | 17-22 | |
| » W: John Hiller (4-1) L: Dennis Martinez (3-3) | Fifth | 8 out |
| » Defeated Tigers (24-14), 1-0 | Memorial Stadium (9-10) | 18-22 | |
| » W: Jim Palmer (5-4) L: Bob Sykes (3-1) | Fifth | 8 out |
| Thursday, May 25 |
| » Defeated Tigers (24-15), 2-1 | Memorial Stadium (10-10) | 19-22 | Won 2 |
| » W: Scott McGregor (4-3) L: John Hiller (4-2) | Fifth | 8 out |
| » Major-league debuts: Steve Baker (Tigers) |
| Friday, May 26 |
| » Defeated Indians (18-22), 4-3 | Memorial Stadium (11-10) | 20-22 | Won 3 |
| » W: Tippy Martinez (1-1) L: Rick Wise (2-8) | Fifth | 8 out |
| Saturday, May 27 |
| » Lost to Indians (19-22), 6-2 | Memorial Stadium (11-11) | 20-23 | |
| » W: David Clyde (3-0) L: Mike Flanagan (5-4) | Fifth | 9 out |
| Sunday, May 28 |
| » Lost to Indians (20-22), 4-3 | Memorial Stadium (11-12) | 20-24 | Lost 2 |
| » W: Sid Monge (2-0) L: Don Stanhouse (0-4) | Fifth | 10 out |
| » Defeated Indians (20-23), 3-0 | Memorial Stadium (12-12) | 21-24 | |
| » W: Jim Palmer (6-4) L: Mike Paxton (1-3) | Fifth | 10 out |
| Monday, May 29 |
| » Defeated Tigers (24-20), 6-3 | Tiger Stadium (1-0) | 22-24 | Won 2 |
| » W: Scott McGregor (5-3) L: Bob Sykes (3-2) | Fifth | 10 out |
| Tuesday, May 30 |
| » Lost to Tigers (25-20), 5-2 | Tiger Stadium (1-1) | 22-25 | |
| » W: Steve Baker (1-0) L: Nelson Briles (1-4) S: John Hiller (5) | Fifth | 11 out |
| Wednesday, May 31 |
| » Defeated Yankees (29-17), 3-2 | Yankee Stadium (2-1) | 23-25 | |
| » W: Mike Flanagan (6-4) L: Ed Figueroa (5-3) | Fifth | 10 out |
| Thursday, June 1 |
| » Defeated Yankees (29-18), 1-0 | Yankee Stadium (3-1) | 24-25 | Won 2 |
| » W: Jim Palmer (7-4) L: Jim Beattie (2-1) | Fifth | 9½ out |
| Friday, June 2 |
| » Defeated Mariners (17-35), 10-9 | Kingdome (1-0) | 25-25 | Won 3 |
| » W: Dennis Martinez (4-3) L: Jim Colborn (1-3) S: Don Stanhouse (8) | Fourth | 9½ out |
| Saturday, June 3 |
| » Defeated Mariners (17-36), 2-1 | Kingdome (2-0) | 26-25 | Won 4 |
| » W: Scott McGregor (6-3) L: Paul Mitchell (2-5) S: Tippy Martinez (1) | Fourth | 9½ out |
| Sunday, June 4 |
| » Defeated Mariners (17-37), 4-1 | Kingdome (3-0) | 27-25 | Won 5 |
| » W: Mike Flanagan (7-4) L: Dick Pole (4-6) | Fourth | 8½ out |
| Monday, June 5 |
| » Defeated Angels (26-24), 6-2 | Anaheim Stadium (1-0) | 28-25 | Won 6 |
| » W: Don Stanhouse (1-4) L: Dave LaRoche (3-2) | Fourth | 7½ out |
| Tuesday, June 6 |
| » Defeated Angels (26-25), 8-6 | Anaheim Stadium (2-0) | 29-25 | Won 7 |
| » W: Dennis Martinez (5-3) L: Nolan Ryan (3-6) S: Don Stanhouse (9) | Fourth | 6½ out |
| Friday, June 9 |
| » Defeated Athletics (32-24), 5-3 | Oakland-Alameda County Stadium (1-0) | 30-25 | Won 8 |
| » W: Mike Flanagan (8-4) L: Pete Broberg (6-5) | Fourth | 6½ out |
| Saturday, June 10 |
| » Defeated Athletics (32-25), 1-0 | Oakland-Alameda County Stadium (2-0) | 31-25 | Won 9 |
| » W: Jim Palmer (8-4) L: Steve Renko (1-2) | Fourth | 6½ out |
| Sunday, June 11 |
| » Defeated Athletics (32-26), 3-0 | Oakland-Alameda County Stadium (3-0) | 32-25 | Won 10 |
| » W: Scott McGregor (7-3) L: Mike Morgan (0-1) | Fourth | 6½ out |
| » Major-league debuts: Mike Morgan (Athletics) |
| Monday, June 12 |
| » Defeated Mariners (19-42), 5-4 | Memorial Stadium (13-12) | 33-25 | Won 11 |
| » W: Tippy Martinez (2-1) L: Jim Colborn (1-5) S: Don Stanhouse (10) | Third | 6½ out |
| Tuesday, June 13 |
| » Defeated Mariners (19-43), 3-2 | Memorial Stadium (14-12) | 34-25 | Won 12 |
| » W: Mike Flanagan (9-4) L: Enrique Romo (3-2) | Third | 6½ out |
| Wednesday, June 14 |
| » Defeated Angels (30-30), 5-2 | Memorial Stadium (15-12) | 35-25 | Won 13 |
| » W: Jim Palmer (9-4) L: Ken Brett (2-4) | Third | 6½ out |
| Thursday, June 15 |
| » Lost to Angels (31-30), 5-1 | Memorial Stadium (15-13) | 35-26 | |
| » W: Frank Tanana (10-3) L: Scott McGregor (7-4) | Third | 7½ out |
| Friday, June 16 |
| » Defeated Athletics (32-31), 6-0 | Memorial Stadium (16-13) | 36-26 | |
| » W: Dennis Martinez (6-3) L: Rick Langford (1-4) | Third | 7½ out |
| Saturday, June 17 |
| » Defeated Athletics (32-32), 5-4 | Memorial Stadium (17-13) | 37-26 | Won 2 |
| » W: Mike Flanagan (10-4) L: Mike Morgan (0-2) S: Don Stanhouse (11) | Third | 7½ out |
| Sunday, June 18 |
| » Defeated Athletics (32-33), 2-1 | Memorial Stadium (18-13) | 38-26 | Won 3 |
| » W: Jim Palmer (10-4) L: John Henry Johnson (4-4) S: Tippy Martinez (2) | Second | 6½ out |
| Tuesday, June 20 |
| » Defeated Brewers (37-28), 8-5 | County Stadium (1-3) | 39-26 | Won 4 |
| » W: Scott McGregor (8-4) L: Bill Travers (3-3) | Second | 6 out |
| Wednesday, June 21 |
| » Lost to Brewers (38-28), 5-3 | County Stadium (1-4) | 39-27 | |
| » W: Lary Sorensen (9-4) L: Dennis Martinez (6-4) S: Bill Castro (5) | Second | 7 out |
| Future Oriole Luis Rivera is born in Chihuahua, Mexico. |
| Thursday, June 22 |
| » Defeated Brewers (38-29), 10-3 | County Stadium (2-4) | 40-27 | |
| » W: Mike Flanagan (11-4) L: Moose Haas (2-3) | Second | 6½ out |
| Future Oriole Willie Harris is born in Cairo, GA. |
| Friday, June 23 |
| » Lost to Red Sox (48-21), 5-2 | Fenway Park (1-2) | 40-28 | |
| » W: Bill Lee (8-3) L: Jim Palmer (10-5) | Second | 7½ out |
| Saturday, June 24 |
| » Lost to Red Sox (49-21), 8-3 | Fenway Park (1-3) | 40-29 | Lost 2 |
| » W: Luis Tiant (7-0) L: Scott McGregor (8-5) | Second | 8½ out |
| Sunday, June 25 |
| » Lost to Red Sox (50-21), 4-1 | Fenway Park (1-4) | 40-30 | Lost 3 |
| » W: Mike Torrez (11-3) L: Dennis Martinez (6-5) | Third | 9½ out |
| Monday, June 26 |
| » Lost to Blue Jays (23-47), 24-10 | Exhibition Stadium (0-1) | 40-31 | Lost 4 |
| » W: Tom Underwood (4-7) L: Mike Flanagan (11-5) | Third | 10½ out |
| Tuesday, June 27 |
| » Lost to Blue Jays (24-47), 6-2 | Exhibition Stadium (0-2) | 40-32 | Lost 5 |
| » W: Dave Lemanczyk (2-9) L: Jim Palmer (10-6) S: Victor Cruz (2) | Fourth | 11 out |
| » Lost to Blue Jays (25-47), 9-8 | Exhibition Stadium (0-3) | 40-33 | Lost 6 |
| » W: Victor Cruz (1-0) L: Don Stanhouse (1-5) | Fourth | 11 out |
| Wednesday, June 28 |
| » Lost to Blue Jays (26-47), 3-2 | Exhibition Stadium (0-4) | 40-34 | Lost 7 |
| » W: Jim Clancy (5-7) L: Scott McGregor (8-6) S: Tom Murphy (6) | Fourth | 11½ out |
| Thursday, June 29 |
| » Lost to Red Sox (52-22), 4-3 | Memorial Stadium (18-14) | 40-35 | Lost 8 |
| » W: Allen Ripley (2-4) L: Dennis Martinez (6-6) | Fourth | 12½ out |
| Friday, June 30 |
| » Defeated Red Sox (52-23), 3-2 | Memorial Stadium (19-14) | 41-35 | |
| » W: Don Stanhouse (2-5) L: Luis Tiant (7-1) | Fourth | 11½ out |
| Saturday, July 1 |
| » Defeated Red Sox (52-24), 3-2 | Memorial Stadium (20-14) | 42-35 | Won 2 |
| » W: Nelson Briles (2-4) L: Mike Torrez (11-4) | Fourth | 10½ out |
| Monday, July 3 |
| » Lost to Indians (37-41), 9-0 | Cleveland Stadium (2-3) | 42-36 | |
| » W: Mike Paxton (6-4) L: Scott McGregor (8-7) | Fourth | 11½ out |
| Tuesday, July 4 |
| » Defeated Indians (37-42), 6-4 | Cleveland Stadium (3-3) | 43-36 | |
| » W: Dennis Martinez (7-6) L: David Clyde (4-4) S: Don Stanhouse (12) | Third | 11 out |
| Wednesday, July 5 |
| » Defeated Blue Jays (29-51), 3-1 | Memorial Stadium (21-14) | 44-36 | Won 2 |
| » W: Mike Flanagan (12-5) L: Jerry Garvin (2-9) | Third | 10½ out |
| » Defeated Blue Jays (29-52), 8-6 | Memorial Stadium (22-14) | 45-36 | Won 3 |
| » W: Joe Kerrigan (1-0) L: Tom Murphy (2-7) | Third | 10½ out |
| Thursday, July 6 |
| » Lost to Blue Jays (30-52), 2-0 | Memorial Stadium (22-15) | 45-37 | |
| » W: Dave Lemanczyk (3-10) L: Jim Palmer (10-7) S: Mike Willis (4) | Fourth | 11½ out |
| Friday, July 7 |
| » Lost to Royals (42-40), 3-1 | Royals Stadium (0-3) | 45-38 | Lost 2 |
| » W: Paul Splittorff (10-7) L: Scott McGregor (8-8) | Fourth | 11½ out |
| Saturday, July 8 |
| » Lost to Royals (43-40), 11-3 | Royals Stadium (0-4) | 45-39 | Lost 3 |
| » W: Rich Gale (9-3) L: Dennis Martinez (7-7) | Fourth | 13 out |
| Sunday, July 9 |
| » Lost to Royals (44-40), 10-4 | Royals Stadium (0-5) | 45-40 | Lost 4 |
| » W: Dennis Leonard (9-11) L: Mike Flanagan (12-6) | Fourth | 13 out |
| Thursday, July 13 |
| » Defeated Twins (39-43), 8-6 | Memorial Stadium (23-15) | 46-40 | |
| » W: Mike Flanagan (13-6) L: Dave Goltz (8-6) S: Tippy Martinez (3) | Fourth | 12 out |
| Friday, July 14 |
| » Defeated Twins (39-44), 5-1 | Memorial Stadium (24-15) | 47-40 | Won 2 |
| » W: Scott McGregor (9-8) L: Geoff Zahn (8-7) | Fourth | 11 out |
| Saturday, July 15 |
| » Defeated Rangers (44-42), 8-7 | Memorial Stadium (25-15) | 48-40 | Won 3 |
| » W: Tippy Martinez (3-1) L: Len Barker (1-4) | Fourth | 11½ out |
| » Lost to Rangers (45-42), 11-1 | Memorial Stadium (25-16) | 48-41 | |
| » W: Doc Medich (4-4) L: Jim Palmer (10-8) | Fourth | 11½ out |
| Sunday, July 16 |
| » Defeated Rangers (45-43), 2-1 | Memorial Stadium (26-16) | 49-41 | |
| » W: Don Stanhouse (3-5) L: Reggie Cleveland (2-5) | Third | 12 out |
| Monday, July 17 |
| » Lost to Rangers (46-43), 2-0 | Memorial Stadium (26-17) | 49-42 | |
| » W: Reggie Cleveland (3-5) L: Mike Flanagan (13-7) | Third | 13 out |
| Tuesday, July 18 |
| » Defeated Rangers (46-44), 5-1 | Memorial Stadium (27-17) | 50-42 | |
| » W: Scott McGregor (10-8) L: Dock Ellis (8-5) | Third | 12½ out |
| Wednesday, July 19 |
| » Defeated White Sox (39-52), 10-3 | Comiskey Park I (4-0) | 51-42 | Won 2 |
| » W: Jim Palmer (11-8) L: Ken Kravec (7-7) | Third | 12½ out |
| Friday, July 21 |
| » Defeated Twins (39-51), 5-4 | Metropolitan Stadium (1-2) | 52-42 | Won 3 |
| » W: Don Stanhouse (4-5) L: Mike Marshall (4-8) | Third | 11 out |
| Saturday, July 22 |
| » Lost to Twins (40-51), 5-4 | Metropolitan Stadium (1-3) | 52-43 | |
| » W: Dave Goltz (9-6) L: Scott McGregor (10-9) | Fourth | 11 out |
| Sunday, July 23 |
| » Defeated Twins (40-52), 8-5 | Metropolitan Stadium (2-3) | 53-43 | |
| » W: Jim Palmer (12-8) L: Gary Serum (4-4) S: Don Stanhouse (13) | Fourth | 10 out |
| Monday, July 24 |
| » Defeated Rangers (46-50), 10-6 | Arlington Stadium (3-1) | 54-43 | Won 2 |
| » W: Don Stanhouse (5-5) L: Fergie Jenkins (9-6) S: Scott McGregor (1) | Third | 9½ out |
| Tuesday, July 25 |
| » Defeated Rangers (46-51), 7-6 | Arlington Stadium (4-1) | 55-43 | Won 3 |
| » W: Joe Kerrigan (2-0) L: Doyle Alexander (6-7) S: Tippy Martinez (4) | Third | 8½ out |
| Wednesday, July 26 |
| » Lost to Tigers (52-47), 9-6 | Tiger Stadium (1-2) | 55-44 | |
| » W: Jack Billingham (10-5) L: Mike Flanagan (13-8) S: Bob Sykes (1) | Fourth | 8½ out |
| Thursday, July 27 |
| » Defeated Tigers (52-48), 7-3 | Tiger Stadium (2-2) | 56-44 | |
| » W: Scott McGregor (11-9) L: Jim Slaton (10-8) | Third | 7½ out |
| Friday, July 28 |
| » Defeated Angels (54-49), 5-4 | Memorial Stadium (28-17) | 57-44 | Won 2 |
| » W: Jim Palmer (13-8) L: Don Aase (7-6) S: Don Stanhouse (14) | Third | 6½ out |
| Saturday, July 29 |
| » Lost to Angels (55-49), 2-1 | Memorial Stadium (28-18) | 57-45 | |
| » W: Paul Hartzell (2-6) L: Dennis Martinez (7-8) | Third | 7½ out |
| Sunday, July 30 |
| » Lost to Angels (56-49), 4-2 | Memorial Stadium (28-19) | 57-46 | Lost 2 |
| » W: Dave Frost (3-4) L: Mike Flanagan (13-9) S: Dave LaRoche (15) | Third | 7½ out |
| Monday, July 31 |
| » Defeated Brewers (59-43), 6-5 | Memorial Stadium (29-19) | 58-46 | |
| » W: Joe Kerrigan (3-0) L: Bill Castro (3-3) | Third | 7½ out |
| Wednesday, August 2 |
| » Lost to Brewers (60-43), 5-3 | Memorial Stadium (29-20) | 58-47 | |
| » W: Mike Caldwell (14-5) L: Jim Palmer (13-9) S: Lary Sorensen (1) | Fourth | 8 out |
| Thursday, August 3 |
| » Defeated Brewers (60-44), 3-2 | Memorial Stadium (30-20) | 59-47 | |
| » W: Dennis Martinez (8-8) L: Jerry Augustine (10-10) | Third | 8 out |
| Friday, August 4 |
| » Defeated Yankees (59-49), 2-1 | Yankee Stadium (4-1) | 60-47 | Won 2 |
| » W: Mike Flanagan (14-9) L: Ron Guidry (15-2) S: Don Stanhouse (15) | Third | 7 out |
| Saturday, August 5 |
| » Lost to Yankees (60-49), 3-2 | Yankee Stadium (4-2) | 60-48 | |
| » W: Sparky Lyle (8-2) L: Tippy Martinez (3-2) | Third | 8 out |
| Sunday, August 6 |
| » Lost to Yankees (61-49), 3-0 | Yankee Stadium (4-3) | 60-49 | Lost 2 |
| » W: Catfish Hunter (5-4) L: Jim Palmer (13-10) | Fourth | 9 out |
| Monday, August 7 |
| » Lost to Blue Jays (41-69), 2-1 | Exhibition Stadium (0-5) | 60-50 | Lost 3 |
| » W: Jim Clancy (8-9) L: Dennis Martinez (8-9) | Fifth | 9½ out |
| Tuesday, August 8 |
| » Lost to Blue Jays (42-69), 5-3 | Exhibition Stadium (0-6) | 60-51 | Lost 4 |
| » W: Tom Underwood (6-10) L: Mike Flanagan (14-10) S: Victor Cruz (7) | Fifth | 10½ out |
| Wednesday, August 9 |
| » Lost to Royals (62-48), 2-0 | Memorial Stadium (30-21) | 60-52 | Lost 5 |
| » W: Larry Gura (10-2) L: Scott McGregor (11-10) | Fifth | 10½ out |
| Thursday, August 10 |
| » Defeated Royals (62-49), 3-2 | Memorial Stadium (31-21) | 61-52 | |
| » W: Jim Palmer (14-10) L: Doug Bird (4-5) S: Don Stanhouse (16) | Fifth | 10½ out |
| Friday, August 11 |
| » Lost to Yankees (65-49), 2-1 | Memorial Stadium (31-22) | 61-53 | |
| » W: Catfish Hunter (6-4) L: Dennis Martinez (8-10) | Fifth | 10½ out |
| Saturday, August 12 |
| » Defeated Yankees (65-50), 6-4 | Memorial Stadium (32-22) | 62-53 | |
| » W: Mike Flanagan (15-10) L: Jim Beattie (2-7) S: Don Stanhouse (17) | Fourth | 11 out |
| Sunday, August 13 |
| » Defeated Yankees (65-51), 3-0 | Memorial Stadium (33-22) | 63-53 | Won 2 |
| » W: Scott McGregor (12-10) L: Ed Figueroa (11-8) | Fifth | 11 out |
| Monday, August 14 |
| » Lost to Yankees (66-51), 4-1 | Memorial Stadium (33-23) | 63-54 | |
| » W: Rich Gossage (8-9) L: Jim Palmer (14-11) | Fifth | 11 out |
| Tuesday, August 15 |
| » Defeated Mariners (44-76), 7-4 | Kingdome (4-0) | 64-54 | |
| » W: Dennis Martinez (9-10) L: Glenn Abbott (5-10) S: Don Stanhouse (18) | Fourth | 10 out |
| Wednesday, August 16 |
| » Lost to Mariners (45-76), 7-5 | Kingdome (4-1) | 64-55 | |
| » W: Byron McLaughlin (1-4) L: Mike Flanagan (15-11) S: Jim Todd (3) | Fifth | 11 out |
| Friday, August 18 |
| » Lost to Angels (67-57), 3-2 | Anaheim Stadium (2-1) | 64-56 | Lost 2 |
| » W: Chris Knapp (12-7) L: Scott McGregor (12-11) | Fifth | 12½ out |
| Saturday, August 19 |
| » Lost to Angels (68-57), 4-3 | Anaheim Stadium (2-2) | 64-57 | Lost 3 |
| » W: Paul Hartzell (5-7) L: Jim Palmer (14-12) | Fifth | 12½ out |
| Sunday, August 20 |
| » Lost to Angels (69-57), 1-0 | Anaheim Stadium (2-3) | 64-58 | Lost 4 |
| » W: Tom Griffin (3-4) L: Don Stanhouse (5-6) | Fourth | 13½ out |
| Monday, August 21 |
| » Defeated Athletics (62-65), 3-2 | Oakland-Alameda County Stadium (4-0) | 65-58 | |
| » W: Mike Flanagan (16-11) L: Rick Langford (6-9) | Fourth | 13 out |
| Tuesday, August 22 |
| » Defeated Athletics (62-66), 6-4 | Oakland-Alameda County Stadium (5-0) | 66-58 | Won 2 |
| » W: Don Stanhouse (6-6) L: Bob Lacey (8-7) S: Joe Kerrigan (1) | Fifth | 12 out |
| Wednesday, August 23 |
| » Defeated Athletics (62-67), 11-0 | Oakland-Alameda County Stadium (6-0) | 67-58 | Won 3 |
| » W: Jim Palmer (15-12) L: Steve Renko (6-9) | Fifth | 11 out |
| Friday, August 25 |
| » Defeated Mariners (49-78), 5-0 | Memorial Stadium (34-23) | 68-58 | Won 4 |
| » W: Dennis Martinez (10-10) L: Paul Mitchell (6-13) | Fifth | 11 out |
| Saturday, August 26 |
| » Defeated Mariners (49-79), 9-2 | Memorial Stadium (35-23) | 69-58 | Won 5 |
| » W: Mike Flanagan (17-11) L: Jim Colborn (4-9) S: Joe Kerrigan (2) | Fifth | 11 out |
| Sunday, August 27 |
| » Defeated Mariners (49-80), 4-3 | Memorial Stadium (36-23) | 70-58 | Won 6 |
| » W: Nelson Briles (3-4) L: Enrique Romo (10-5) | Fifth | 11 out |
| Monday, August 28 |
| » Defeated Athletics (62-71), 7-3 | Memorial Stadium (37-23) | 71-58 | Won 7 |
| » W: Jim Palmer (16-12) L: Bob Lacey (8-9) | Fifth | 11 out |
| Tuesday, August 29 |
| » Defeated Athletics (62-72), 6-2 | Memorial Stadium (38-23) | 72-58 | Won 8 |
| » W: Dennis Martinez (11-10) L: Mike Norris (0-2) | Fifth | 11 out |
| Future Oriole Eddie Rogers is born in San Pedro de Macoris, D.R. |
| Wednesday, August 30 |
| » Lost to Yankees (76-54), 5-4 | Memorial Stadium (38-24) | 72-59 | |
| » W: Ron Guidry (19-2) L: Tippy Martinez (3-3) S: Rich Gossage (20) | Fifth | 11½ out |
| Thursday, August 31 |
| » Lost to Yankees (77-54), 6-2 | Memorial Stadium (38-25) | 72-60 | Lost 2 |
| » W: Dick Tidrow (6-9) L: Scott McGregor (12-12) S: Sparky Lyle (8) | Fifth | 12 out |
| Friday, September 1 |
| » Defeated White Sox (56-76), 3-0 | Memorial Stadium (39-25) | 73-60 | |
| » W: Jim Palmer (17-12) L: Steve Stone (10-11) S: Don Stanhouse (19) | Fifth | 10½ out |
| » Defeated White Sox (56-77), 9-3 | Memorial Stadium (40-25) | 74-60 | Won 2 |
| » W: Sammy Stewart (1-0) L: Ross Baumgarten (2-2) S: Joe Kerrigan (3) | Fifth | 10½ out |
| » Major-league debuts: Sammy Stewart (Orioles) |
| Saturday, September 2 |
| » Defeated White Sox (56-78), 9-4 | Memorial Stadium (41-25) | 75-60 | Won 3 |
| » W: Dennis Martinez (12-10) L: Ken Kravec (10-13) | Fourth | 9 out |
| » Defeated White Sox (56-79), 1-0 | Memorial Stadium (42-25) | 76-60 | Won 4 |
| » W: Dave Ford (1-0) L: Jack Kucek (0-2) S: Tippy Martinez (5) | Fourth | 9 out |
| » Major-league debuts: Dave Ford (Orioles) |
| Sunday, September 3 |
| » Lost to White Sox (57-79), 4-2 | Memorial Stadium (42-26) | 76-61 | |
| » W: Lerrin LaGrow (4-4) L: Mike Flanagan (17-12) | Fourth | 10 out |
| Monday, September 4 |
| » Defeated Red Sox (85-51), 5-3 | Memorial Stadium (43-26) | 77-61 | |
| » W: Scott McGregor (13-12) L: Dennis Eckersley (16-6) S: Don Stanhouse (20) | Fourth | 9 out |
| Tuesday, September 5 |
| » Defeated Red Sox (85-52), 4-1 | Memorial Stadium (44-26) | 78-61 | Won 2 |
| » W: Jim Palmer (18-12) L: Bobby Sprowl (0-1) S: Don Stanhouse (21) | Fourth | 8 out |
| Wednesday, September 6 |
| » Lost to Red Sox (86-52), 2-0 | Memorial Stadium (44-27) | 78-62 | |
| » W: Luis Tiant (10-7) L: Dennis Martinez (12-11) | Fourth | 9 out |
| Friday, September 8 |
| » Defeated Blue Jays (56-87), 5-4 | Exhibition Stadium (1-6) | 79-62 | |
| » W: Nelson Briles (4-4) L: Tom Underwood (6-13) S: Don Stanhouse (22) | Fourth | 7½ out |
| Saturday, September 9 |
| » Defeated Blue Jays (56-88), 4-0 | Exhibition Stadium (2-6) | 80-62 | Won 2 |
| » W: Scott McGregor (14-12) L: Balor Moore (6-7) | Fourth | 6½ out |
| Monday, September 11 |
| » Lost to Red Sox (87-56), 5-4 | Fenway Park (1-5) | 80-63 | |
| » W: Bob Stanley (14-2) L: Joe Kerrigan (3-1) | Fourth | 7 out |
| Tuesday, September 12 |
| » Defeated Red Sox (87-57), 3-2 | Fenway Park (2-5) | 81-63 | |
| » W: Dennis Martinez (13-11) L: Mike Torrez (15-10) | Fourth | 6 out |
| Wednesday, September 13 |
| » Lost to Brewers (84-62), 7-5 | County Stadium (2-5) | 81-64 | |
| » W: Andy Replogle (9-2) L: Mike Flanagan (17-13) S: Ed Farmer (1) | Fourth | 6½ out |
| Thursday, September 14 |
| » Lost to Brewers (85-62), 4-3 | County Stadium (2-6) | 81-65 | Lost 2 |
| » W: Mike Caldwell (19-9) L: Scott McGregor (14-13) | Fourth | 7½ out |
| Friday, September 15 |
| » Defeated Blue Jays (57-90), 8-3 | Memorial Stadium (45-27) | 82-65 | |
| » W: Jim Palmer (19-12) L: Victor Cruz (7-2) | Fourth | 7½ out |
| Saturday, September 16 |
| » Defeated Blue Jays (57-91), 11-1 | Memorial Stadium (46-27) | 83-65 | Won 2 |
| » W: Dennis Martinez (14-11) L: Jesse Jefferson (7-14) | Fourth | 7½ out |
| Sunday, September 17 |
| » Defeated Blue Jays (57-92), 5-0 | Memorial Stadium (47-27) | 84-65 | Won 3 |
| » W: Mike Flanagan (18-13) L: Don Kirkwood (4-4) | Fourth | 6½ out |
| Monday, September 18 |
| » Defeated Indians (65-84), 10-3 | Cleveland Stadium (4-3) | 85-65 | Won 4 |
| » W: Scott McGregor (15-13) L: David Clyde (7-11) | Third | 6½ out |
| Tuesday, September 19 |
| » Lost to Indians (66-84), 2-1 | Cleveland Stadium (4-4) | 85-66 | |
| » W: Mike Paxton (12-9) L: Don Stanhouse (6-7) | Fourth | 6½ out |
| Friday, September 22 |
| » Lost to Tigers (82-71), 7-5 | Memorial Stadium (47-28) | 85-67 | Lost 2 |
| » W: John Hiller (8-4) L: Mike Flanagan (18-14) | Fourth | 7 out |
| Saturday, September 23 |
| » Lost to Tigers (83-71), 4-3 | Memorial Stadium (47-29) | 85-68 | Lost 3 |
| » W: John Hiller (9-4) L: Don Stanhouse (6-8) | Fourth | 6½ out |
| » Defeated Tigers (83-72), 6-1 | Memorial Stadium (48-29) | 86-68 | |
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