| Wednesday, April 5 |
| » Defeated Twins (0-1), 3-2 | Kingdome (1-0) | 1-0 | |
| » W: Glenn Abbott (1-0) L: Dave Goltz (0-1) S: Enrique Romo (1) | First | -- |
| » Major-league debuts: Hosken Powell (Twins) |
| Thursday, April 6 |
| » Lost to Twins (1-1), 5-4 | Kingdome (1-1) | 1-1 | |
| » W: Roger Erickson (1-0) L: Dick Pole (0-1) S: Tom Johnson (1) | Second | 1 out |
| » Major-league debuts: Shane Rawley (Mariners) Roger Erickson (Twins) |
| Friday, April 7 |
| » Defeated Twins (1-2), 6-3 | Kingdome (2-1) | 2-1 | |
| » W: Rick Honeycutt (1-0) L: Pete Redfern (0-1) S: Enrique Romo (2) | Second | 1 out |
| Saturday, April 8 |
| » Lost to Twins (2-2), 8-2 | Kingdome (2-2) | 2-2 | |
| » W: Paul Thormodsgard (1-0) L: Paul Mitchell (0-1) | Fourth | 1 out |
| Sunday, April 9 |
| » Lost to Twins (3-2), 8-6 | Kingdome (2-3) | 2-3 | Lost 2 |
| » W: Gary Serum (1-0) L: Tom House (0-1) | Fourth | 1 out |
| Monday, April 10 |
| » Lost to Athletics (2-2), 1-0 | Oakland-Alameda County Stadium (0-1) | 2-4 | Lost 3 |
| » W: John Henry Johnson (1-0) L: Glenn Abbott (1-1) S: Dave Heaverlo (2) | Fifth | 2 out |
| Tuesday, April 11 |
| » Lost to Athletics (3-2), 2-0 | Oakland-Alameda County Stadium (0-2) | 2-5 | Lost 4 |
| » W: Pete Broberg (1-0) L: Dick Pole (0-2) S: Elias Sosa (1) | Sixth | 2½ out |
| Wednesday, April 12 |
| » Lost to Athletics (4-2), 4-3 | Oakland-Alameda County Stadium (0-3) | 2-6 | Lost 5 |
| » W: Dave Heaverlo (1-0) L: Shane Rawley (0-1) | Sixth | 3½ out |
| Thursday, April 13 |
| » Lost to Athletics (5-2), 3-1 | Oakland-Alameda County Stadium (0-4) | 2-7 | Lost 6 |
| » W: Bob Lacey (2-0) L: Steve Burke (0-1) | Sixth | 3½ out |
| Friday, April 14 |
| » Lost to Twins (5-5), 14-5 | Metropolitan Stadium (0-1) | 2-8 | Lost 7 |
| » W: Geoff Zahn (1-0) L: Tom House (0-2) | Seventh | 4½ out |
| Saturday, April 15 |
| » Lost to Twins (6-5), 6-5 | Metropolitan Stadium (0-2) | 2-9 | Lost 8 |
| » W: Tom Johnson (1-1) L: John Montague (0-1) | Seventh | 5½ out |
| Sunday, April 16 |
| » Defeated Twins (6-6), 8-5 | Metropolitan Stadium (1-2) | 3-9 | |
| » W: Dick Pole (1-2) L: Roger Erickson (2-1) S: Shane Rawley (1) | Fifth | 5 out |
| » Defeated Twins (6-7), 7-2 | Metropolitan Stadium (2-2) | 4-9 | Won 2 |
| » W: Tom House (1-2) L: Dave Johnson (0-1) | Fifth | 5 out |
| Monday, April 17 |
| » Lost to Angels (7-3), 7-3 | Kingdome (2-4) | 4-10 | |
| » W: Frank Tanana (3-0) L: Rick Honeycutt (1-1) | Fifth | 6 out |
| Tuesday, April 18 |
| » Defeated Angels (7-4), 6-1 | Kingdome (3-4) | 5-10 | |
| » W: Paul Mitchell (1-1) L: Nolan Ryan (0-1) | Sixth | 6 out |
| Wednesday, April 19 |
| » Lost to Angels (8-4), 11-2 | Kingdome (3-5) | 5-11 | |
| » W: Chris Knapp (2-1) L: Jim Todd (0-1) S: Paul Hartzell (2) | Sixth | 6½ out |
| Friday, April 21 |
| » Lost to Athletics (9-3), 5-3 | Kingdome (3-6) | 5-12 | Lost 2 |
| » W: Matt Keough (1-0) L: Dick Pole (1-3) S: Elias Sosa (2) | Sixth | 6½ out |
| Saturday, April 22 |
| » Lost to Athletics (10-3), 3-0 | Kingdome (3-7) | 5-13 | Lost 3 |
| » W: Alan Wirth (1-1) L: Rick Honeycutt (1-2) S: Elias Sosa (3) | Sixth | 7½ out |
| Sunday, April 23 |
| » Lost to Athletics (11-3), 5-0 | Kingdome (3-8) | 5-14 | Lost 4 |
| » W: John Henry Johnson (2-0) L: Paul Mitchell (1-2) | Sixth | 8½ out |
| Monday, April 24 |
| » Defeated Angels (10-5), 6-5 | Anaheim Stadium (1-0) | 6-14 | |
| » W: Enrique Romo (1-0) L: Paul Hartzell (0-2) S: Shane Rawley (2) | Sixth | 8½ out |
| Tuesday, April 25 |
| » Lost to Angels (11-5), 3-0 | Anaheim Stadium (1-1) | 6-15 | |
| » W: Chris Knapp (3-1) L: Byron McLaughlin (0-1) S: Dave LaRoche (4) | Seventh | 9½ out |
| Wednesday, April 26 |
| » Defeated Angels (11-6), 5-4 | Anaheim Stadium (2-1) | 7-15 | |
| » W: Dick Pole (2-3) L: Ken Brett (1-1) S: Shane Rawley (3) | Sixth | 9½ out |
| Thursday, April 27 |
| » Lost to Angels (12-6), 5-1 | Anaheim Stadium (2-2) | 7-16 | |
| » W: Frank Tanana (5-0) L: Jim Todd (0-2) | Seventh | 9½ out |
| Friday, April 28 |
| » Lost to Tigers (12-4), 5-4 | Kingdome (3-9) | 7-17 | Lost 2 |
| » W: Jim Slaton (2-1) L: Rick Honeycutt (1-3) S: John Hiller (1) | Seventh | 9½ out |
| Saturday, April 29 |
| » Lost to Tigers (13-4), 5-0 | Kingdome (3-10) | 7-18 | Lost 3 |
| » W: Dave Rozema (2-0) L: Paul Mitchell (1-3) | Seventh | 10½ out |
| Sunday, April 30 |
| » Defeated Tigers (13-5), 4-3 | Kingdome (4-10) | 8-18 | |
| » W: Enrique Romo (2-0) L: Steve Foucault (0-1) | Seventh | 10½ out |
| Tuesday, May 2 |
| » Lost to Indians (9-11), 4-1 | Kingdome (4-11) | 8-19 | |
| » W: Rick Waits (2-1) L: Dick Pole (2-4) S: Jim Kern (2) | Seventh | 11½ out |
| Wednesday, May 3 |
| » Lost to Indians (10-11), 10-5 | Kingdome (4-12) | 8-20 | Lost 2 |
| » W: Don Hood (3-0) L: Byron McLaughlin (0-2) S: Dennis Kinney (3) | Seventh | 12½ out |
| Friday, May 5 |
| » Defeated Blue Jays (8-16), 9-1 | Kingdome (5-12) | 9-20 | |
| » W: Rick Honeycutt (2-3) L: Jesse Jefferson (1-4) | Sixth | 12½ out |
| Saturday, May 6 |
| » Defeated Blue Jays (8-17), 6-0 | Kingdome (6-12) | 10-20 | Won 2 |
| » W: Paul Mitchell (2-3) L: Dave Lemanczyk (0-6) | Fifth | 11½ out |
| Sunday, May 7 |
| » Defeated Blue Jays (8-18), 9-7 | Kingdome (7-12) | 11-20 | Won 3 |
| » W: Enrique Romo (3-0) L: Mike Willis (0-2) | Fifth | 10½ out |
| Tuesday, May 9 |
| » Lost to Indians (11-14), 5-4 | Cleveland Stadium (0-1) | 11-21 | |
| » W: Jim Kern (3-1) L: Shane Rawley (0-2) | Fifth | 10½ out |
| Wednesday, May 10 |
| » Lost to Indians (12-14), 6-1 | Cleveland Stadium (0-2) | 11-22 | Lost 2 |
| » W: Rick Wise (2-5) L: Rick Honeycutt (2-4) S: Dennis Kinney (4) | Sixth | 10½ out |
| Friday, May 12 |
| » Lost to Blue Jays (11-18), 8-3 | Exhibition Stadium (0-1) | 11-23 | Lost 3 |
| » W: Jesse Jefferson (2-4) L: Shane Rawley (0-3) | Sixth | 11½ out |
| Saturday, May 13 |
| » Defeated Blue Jays (11-19), 9-6 | Exhibition Stadium (1-1) | 12-23 | |
| » W: Dick Pole (3-4) L: Dave Lemanczyk (0-7) S: Enrique Romo (3) | Sixth | 11½ out |
| Monday, May 15 |
| » Lost to Tigers (19-9), 4-2 | Tiger Stadium (0-1) | 12-24 | |
| » W: Jim Slaton (4-1) L: Glenn Abbott (1-2) | Fifth | 12 out |
| Tuesday, May 16 |
| » Lost to Tigers (20-9), 4-2 | Tiger Stadium (0-2) | 12-25 | Lost 2 |
| » W: Steve Foucault (1-2) L: Shane Rawley (0-4) | Sixth | 12 out |
| Friday, May 19 |
| » Defeated Rangers (17-16), 6-5 | Kingdome (8-12) | 13-25 | |
| » W: Tom House (2-2) L: Steve Comer (0-1) | Sixth | 10½ out |
| » Lost to Rangers (18-16), 4-2 | Kingdome (8-13) | 13-26 | |
| » W: Doc Medich (1-1) L: Paul Mitchell (2-4) S: Paul Lindblad (1) | Sixth | 10½ out |
| Saturday, May 20 |
| » Defeated Rangers (18-17), 7-3 | Kingdome (9-13) | 14-26 | |
| » W: Shane Rawley (1-4) L: Fergie Jenkins (4-2) S: Enrique Romo (4) | Sixth | 10½ out |
| » Major-league debuts: Nelson Norman (Rangers) |
| Sunday, May 21 |
| » Lost to Rangers (19-17), 5-4 | Kingdome (9-14) | 14-27 | |
| » W: Doyle Alexander (4-2) L: Enrique Romo (3-1) S: Reggie Cleveland (4) | Sixth | 11 out |
| Monday, May 22 |
| » Defeated Royals (19-18), 10-1 | Kingdome (10-14) | 15-27 | |
| » W: Tom House (3-2) L: Dennis Leonard (3-8) | Fifth | 10½ out |
| Tuesday, May 23 |
| » Defeated Royals (19-19), 4-3 | Kingdome (11-14) | 16-27 | Won 2 |
| » W: Dick Pole (4-4) L: Andy Hassler (0-1) S: Jim Todd (1) | Sixth | 10 out |
| » Lost to Royals (20-19), 5-3 | Kingdome (11-15) | 16-28 | |
| » W: Doug Bird (3-2) L: Shane Rawley (1-5) S: Al Hrabosky (6) | Sixth | 10 out |
| Wednesday, May 24 |
| » Lost to Royals (21-19), 6-5 | Kingdome (11-16) | 16-29 | Lost 2 |
| » W: Steve Mingori (1-0) L: Jim Todd (0-3) S: Al Hrabosky (7) | Sixth | 10 out |
| Thursday, May 25 |
| » Lost to Royals (22-19), 9-4 | Kingdome (11-17) | 16-30 | Lost 3 |
| » W: Paul Splittorff (5-4) L: Glenn Abbott (1-3) | Sixth | 11 out |
| Friday, May 26 |
| » Defeated Rangers (21-20), 6-4 | Arlington Stadium (1-0) | 17-30 | |
| » W: Shane Rawley (2-5) L: Doyle Alexander (4-3) S: Enrique Romo (5) | Sixth | 11 out |
| Saturday, May 27 |
| » Lost to Rangers (22-20), 3-2 | Arlington Stadium (1-1) | 17-31 | |
| » W: Jon Matlack (5-5) L: Tom House (3-3) S: Reggie Cleveland (5) | Sixth | 11½ out |
| Monday, May 29 |
| » Lost to Royals (24-19), 8-2 | Royals Stadium (0-1) | 17-32 | Lost 2 |
| » W: Rich Gale (5-0) L: Dick Pole (4-5) | Seventh | 11½ out |
| Wednesday, May 31 |
| » Lost to Royals (25-19), 8-3 | Royals Stadium (0-2) | 17-33 | Lost 3 |
| » W: Paul Splittorff (6-4) L: Glenn Abbott (1-4) | Seventh | 11½ out |
| Thursday, June 1 |
| » Lost to Royals (26-19), 10-0 | Royals Stadium (0-3) | 17-34 | Lost 4 |
| » W: Dennis Leonard (4-8) L: Tom House (3-4) | Seventh | 12 out |
| Friday, June 2 |
| » Lost to Orioles (25-25), 10-9 | Kingdome (11-18) | 17-35 | Lost 5 |
| » W: Dennis Martinez (4-3) L: Jim Colborn (1-3) S: Don Stanhouse (8) | Seventh | 12 out |
| Saturday, June 3 |
| » Lost to Orioles (26-25), 2-1 | Kingdome (11-19) | 17-36 | Lost 6 |
| » W: Scott McGregor (6-3) L: Paul Mitchell (2-5) S: Tippy Martinez (1) | Seventh | 13 out |
| Sunday, June 4 |
| » Lost to Orioles (27-25), 4-1 | Kingdome (11-20) | 17-37 | Lost 7 |
| » W: Mike Flanagan (7-4) L: Dick Pole (4-6) | Seventh | 14 out |
| Monday, June 5 |
| » Defeated Yankees (30-21), 7-3 | Kingdome (12-20) | 18-37 | |
| » W: Tom House (4-4) L: Ed Figueroa (5-4) | Seventh | 14 out |
| Tuesday, June 6 |
| » Defeated Yankees (30-22), 4-3 | Kingdome (13-20) | 19-37 | Won 2 |
| » W: Shane Rawley (3-5) L: Rich Gossage (3-5) | Seventh | 14 out |
| Wednesday, June 7 |
| » Lost to Yankees (31-22), 9-1 | Kingdome (13-21) | 19-38 | |
| » W: Ron Guidry (9-0) L: Jim Colborn (1-4) | Seventh | 14½ out |
| Friday, June 9 |
| » Lost to Red Sox (37-19), 3-2 | Kingdome (13-22) | 19-39 | Lost 2 |
| » W: Luis Tiant (5-0) L: Paul Mitchell (2-6) | Seventh | 14 out |
| Saturday, June 10 |
| » Lost to Red Sox (38-19), 13-1 | Kingdome (13-23) | 19-40 | Lost 3 |
| » W: Mike Torrez (9-2) L: Dick Pole (4-7) | Seventh | 14 out |
| Sunday, June 11 |
| » Lost to Red Sox (39-19), 5-3 | Kingdome (13-24) | 19-41 | Lost 4 |
| » W: Dennis Eckersley (6-2) L: Byron McLaughlin (0-3) S: Bill Campbell (2) | Seventh | 14 out |
| Monday, June 12 |
| » Lost to Orioles (33-25), 5-4 | Memorial Stadium (0-1) | 19-42 | Lost 5 |
| » W: Tippy Martinez (2-1) L: Jim Colborn (1-5) S: Don Stanhouse (10) | Seventh | 14 out |
| Tuesday, June 13 |
| » Lost to Orioles (34-25), 3-2 | Memorial Stadium (0-2) | 19-43 | Lost 6 |
| » W: Mike Flanagan (9-4) L: Enrique Romo (3-2) | Seventh | 14 out |
| Wednesday, June 14 |
| » Lost to Yankees (35-24), 11-9 | Yankee Stadium (0-1) | 19-44 | Lost 7 |
| » W: Sparky Lyle (4-1) L: John Montague (0-2) | Seventh | 14 out |
| Thursday, June 15 |
| » Lost to Yankees (36-24), 5-2 | Yankee Stadium (0-2) | 19-45 | Lost 8 |
| » W: Don Gullett (1-0) L: Paul Mitchell (2-7) S: Sparky Lyle (7) | Seventh | 15 out |
| Friday, June 16 |
| » Lost to Red Sox (44-19), 6-3 | Fenway Park (0-1) | 19-46 | Lost 9 |
| » W: Bill Campbell (4-4) L: Dick Pole (4-8) | Seventh | 16 out |
| Saturday, June 17 |
| » Lost to Red Sox (45-19), 5-4 | Fenway Park (0-2) | 19-47 | Lost 10 |
| » W: Bob Stanley (5-1) L: John Montague (0-3) | Seventh | 16 out |
| Sunday, June 18 |
| » Defeated Red Sox (45-20), 3-2 | Fenway Park (1-2) | 20-47 | |
| » W: Glenn Abbott (2-4) L: Jim Wright (3-1) | Seventh | 15½ out |
| Monday, June 19 |
| » Defeated White Sox (31-33), 7-4 | Comiskey Park I (1-0) | 21-47 | Won 2 |
| » W: Mike Parrott (1-0) L: Jack Kucek (0-1) S: Enrique Romo (6) | Seventh | 15½ out |
| Tuesday, June 20 |
| » Defeated White Sox (31-34), 4-2 | Comiskey Park I (2-0) | 22-47 | Won 3 |
| » W: Paul Mitchell (3-7) L: Steve Stone (6-5) S: Enrique Romo (7) | Seventh | 15½ out |
| Thursday, June 22 |
| » Defeated White Sox (31-35), 8-6 | Comiskey Park I (3-0) | 23-47 | Won 4 |
| » W: John Montague (1-3) L: Jim Willoughby (0-5) | Seventh | 14½ out |
| Friday, June 23 |
| » Defeated Brewers (38-30), 3-0 | County Stadium (1-0) | 24-47 | Won 5 |
| » W: Glenn Abbott (3-4) L: Mike Caldwell (7-5) | Seventh | 14 out |
| Saturday, June 24 |
| » Lost to Brewers (39-30), 5-0 | County Stadium (1-1) | 24-48 | |
| » W: Jerry Augustine (8-8) L: Jim Colborn (1-6) | Seventh | 15 out |
| Sunday, June 25 |
| » Defeated Brewers (39-31), 10-8 | County Stadium (2-1) | 25-48 | |
| » W: Enrique Romo (4-2) L: Randy Stein (2-2) S: John Montague (1) | Seventh | 14½ out |
| Monday, June 26 |
| » Defeated White Sox (32-39), 8-3 | Kingdome (14-24) | 26-48 | Won 2 |
| » W: Paul Mitchell (4-7) L: Francisco Barrios (5-7) S: Shane Rawley (4) | Sixth | 14 out |
| Tuesday, June 27 |
| » Lost to White Sox (33-39), 10-6 | Kingdome (14-25) | 26-49 | |
| » W: Wilbur Wood (8-5) L: Dick Pole (4-9) | Seventh | 15 out |
| Wednesday, June 28 |
| » Lost to White Sox (34-39), 4-2 | Kingdome (14-26) | 26-50 | Lost 2 |
| » W: Ken Kravec (7-5) L: Glenn Abbott (3-5) S: Lerrin LaGrow (9) | Seventh | 15 out |
| Thursday, June 29 |
| » Defeated White Sox (34-40), 9-7 | Kingdome (15-26) | 27-50 | |
| » W: Enrique Romo (5-2) L: Lerrin LaGrow (1-3) | Seventh | 14 out |
| Friday, June 30 |
| » Lost to Brewers (44-31), 13-3 | Kingdome (15-27) | 27-51 | |
| » W: Bill Travers (4-3) L: Mike Parrott (1-1) S: Eduardo Rodriguez (2) | Seventh | 14 out |
| Saturday, July 1 |
| » Lost to Brewers (45-31), 4-0 | Kingdome (15-28) | 27-52 | Lost 2 |
| » W: Lary Sorensen (11-4) L: Paul Mitchell (4-8) | Seventh | 15 out |
| Sunday, July 2 |
| » Defeated Brewers (45-32), 4-3 | Kingdome (16-28) | 28-52 | |
| » W: Shane Rawley (4-5) L: Bill Castro (3-1) | Seventh | 14 out |
| Future Mariner Greg Dobbs is born in Los Angeles, CA. |
| Monday, July 3 |
| » Lost to Athletics (41-39), 5-3 | Kingdome (16-29) | 28-53 | |
| » W: Pete Broberg (9-6) L: Glenn Abbott (3-6) S: Dave Heaverlo (4) | Seventh | 15 out |
| Tuesday, July 4 |
| » Lost to Athletics (42-39), 9-4 | Kingdome (16-30) | 28-54 | Lost 2 |
| » W: Elias Sosa (5-2) L: Rick Honeycutt (2-5) | Seventh | 15 out |
| Wednesday, July 5 |
| » Lost to Athletics (43-39), 5-3 | Kingdome (16-31) | 28-55 | Lost 3 |
| » W: Matt Keough (6-4) L: Shane Rawley (4-6) S: Dave Heaverlo (5) | Seventh | 15½ out |
| Thursday, July 6 |
| » Defeated Athletics (43-40), 3-2 | Kingdome (17-31) | 29-55 | |
| » W: Paul Mitchell (5-8) L: John Henry Johnson (5-5) S: Enrique Romo (8) | Seventh | 15 out |
| Friday, July 7 |
| » Lost to Angels (44-39), 9-5 | Anaheim Stadium (2-3) | 29-56 | |
| » W: Frank Tanana (12-5) L: Dick Pole (4-10) S: Dave LaRoche (12) | Seventh | 16 out |
| Saturday, July 8 |
| » Lost to Angels (45-39), 10-5 | Anaheim Stadium (2-4) | 29-57 | Lost 2 |
| » W: Chris Knapp (10-6) L: Glenn Abbott (3-7) S: Dave LaRoche (13) | Seventh | 18 out |
| » Lost to Angels (46-39), 5-0 | Anaheim Stadium (2-5) | 29-58 | Lost 3 |
| » W: Dave Frost (2-1) L: Jim Colborn (1-7) | Seventh | 18 out |
| Sunday, July 9 |
| » Defeated Angels (46-40), 11-7 | Anaheim Stadium (3-5) | 30-58 | |
| » W: Enrique Romo (6-2) L: Nolan Ryan (3-8) | Seventh | 17 out |
| Thursday, July 13 |
| » Defeated Tigers (42-43), 5-4 | Kingdome (18-31) | 31-58 | Won 2 |
| » W: Enrique Romo (7-2) L: Jim Crawford (2-3) | Seventh | 17 out |
| Friday, July 14 |
| » Lost to Tigers (43-43), 2-0 | Kingdome (18-32) | 31-59 | |
| » W: Jim Slaton (9-6) L: Shane Rawley (4-7) | Seventh | 18 out |
| Saturday, July 15 |
| » Defeated Indians (40-48), 7-6 | Kingdome (19-32) | 32-59 | |
| » W: Enrique Romo (8-2) L: Mike Paxton (6-6) | Seventh | 18 out |
| Sunday, July 16 |
| » Lost to Indians (41-48), 8-4 | Kingdome (19-33) | 32-60 | |
| » W: David Clyde (5-5) L: Paul Mitchell (5-9) S: Sid Monge (4) | Seventh | 18 out |
| Monday, July 17 |
| » Lost to Indians (42-48), 5-2 | Kingdome (19-34) | 32-61 | Lost 2 |
| » W: Dave Freisleben (1-5) L: Jim Colborn (1-8) S: Sid Monge (5) | Seventh | 18 out |
| Tuesday, July 18 |
| » Lost to Blue Jays (33-58), 13-12 | Kingdome (19-35) | 32-62 | Lost 3 |
| » W: Tom Murphy (3-7) L: Dick Pole (4-11) | Seventh | 18½ out |
| Wednesday, July 19 |
| » Defeated Blue Jays (33-59), 6-2 | Kingdome (20-35) | 33-62 | |
| » W: Rick Honeycutt (3-5) L: Jesse Jefferson (6-8) S: John Montague (2) | Seventh | 18½ out |
| Friday, July 21 |
| » Lost to Indians (44-49), 11-0 | Cleveland Stadium (0-3) | 33-63 | |
| » W: Mike Paxton (7-6) L: Mike Parrott (1-2) | Seventh | 20 out |
| Saturday, July 22 |
| » Lost to Indians (45-49), 8-5 | Cleveland Stadium (0-4) | 33-64 | Lost 2 |
| » W: Paul Reuschel (3-0) L: Paul Mitchell (5-10) | Seventh | 21 out |
| Monday, July 24 |
| » Defeated Blue Jays (35-62), 1-0 | Exhibition Stadium (2-1) | 34-64 | |
| » W: Rick Honeycutt (4-5) L: Dave Lemanczyk (3-12) | Seventh | 21 out |
| » Defeated Blue Jays (35-63), 7-2 | Exhibition Stadium (3-1) | 35-64 | Won 2 |
| » W: Jim Colborn (2-8) L: Jesse Jefferson (6-9) S: Enrique Romo (9) | Seventh | 21 out |
| Tuesday, July 25 |
| » Defeated Blue Jays (35-64), 4-2 | Exhibition Stadium (4-1) | 36-64 | Won 3 |
| » W: Glenn Abbott (4-7) L: Tom Underwood (5-10) | Seventh | 20 out |
| Wednesday, July 26 |
| » Lost to Royals (55-42), 12-3 | Royals Stadium (0-4) | 36-65 | |
| » W: Doug Bird (4-4) L: Mike Parrott (1-3) S: Steve Mingori (5) | Seventh | 21 out |
| Thursday, July 27 |
| » Lost to Royals (56-42), 3-1 | Royals Stadium (0-5) | 36-66 | Lost 2 |
| » W: Larry Gura (8-2) L: Paul Mitchell (5-11) | Seventh | 22 out |
| Friday, July 28 |
| » Lost to Tigers (53-48), 4-3 | Tiger Stadium (0-3) | 36-67 | Lost 3 |
| » W: Dave Rozema (5-5) L: Enrique Romo (8-3) | Seventh | 23 out |
| Saturday, July 29 |
| » Lost to Tigers (54-48), 9-1 | Tiger Stadium (0-4) | 36-68 | Lost 4 |
| » W: Kip Young (2-1) L: Rick Honeycutt (4-6) | Seventh | 23 out |
| Sunday, July 30 |
| » Lost to Tigers (55-48), 5-4 | Tiger Stadium (0-5) | 36-69 | Lost 5 |
| » W: Milt Wilcox (8-8) L: Glenn Abbott (4-8) S: Bob Sykes (2) | Seventh | 24 out |
| Tuesday, August 1 |
| » Defeated Twins (45-57), 13-6 | Kingdome (21-35) | 37-69 | |
| » W: Tom House (5-4) L: Stan Perzanowski (1-1) | Sixth | 22½ out |
| Wednesday, August 2 |
| » Defeated Twins (45-58), 3-1 | Kingdome (22-35) | 38-69 | Won 2 |
| » W: Jim Colborn (3-8) L: Geoff Zahn (8-10) | Seventh | 21½ out |
| Thursday, August 3 |
| » Defeated Twins (45-59), 6-5 | Kingdome (23-35) | 39-69 | Won 3 |
| » W: Enrique Romo (9-3) L: Mike Marshall (5-10) | Seventh | 21 out |
| Friday, August 4 |
| » Lost to Athletics (57-53), 6-1 | Oakland-Alameda County Stadium (0-5) | 39-70 | |
| » W: John Henry Johnson (9-6) L: Glenn Abbott (4-9) | Seventh | 21 out |
| Saturday, August 5 |
| » Defeated Athletics (57-54), 3-2 | Oakland-Alameda County Stadium (1-5) | 40-70 | |
| » W: Jim Todd (1-3) L: Matt Keough (7-8) | Seventh | 21 out |
| Future Mariner Jamal Strong is born in Pasadena, CA. |
| Sunday, August 6 |
| » Lost to Athletics (58-54), 4-3 | Oakland-Alameda County Stadium (1-6) | 40-71 | |
| » W: Rick Langford (5-7) L: Shane Rawley (4-8) | Seventh | 22½ out |
| » Lost to Athletics (59-54), 4-3 | Oakland-Alameda County Stadium (1-7) | 40-72 | Lost 2 |
| » W: Bob Lacey (8-5) L: Enrique Romo (9-4) | Seventh | 22½ out |
| Monday, August 7 |
| » Defeated Twins (46-63), 6-5 | Metropolitan Stadium (3-2) | 41-72 | |
| » W: Jim Todd (2-3) L: Stan Perzanowski (1-3) | Sixth | 21½ out |
| Tuesday, August 8 |
| » Lost to Twins (47-63), 10-2 | Metropolitan Stadium (3-3) | 41-73 | |
| » W: Gary Serum (5-5) L: Rick Honeycutt (4-7) | Seventh | 22½ out |
| Wednesday, August 9 |
| » Defeated Twins (47-64), 4-1 | Metropolitan Stadium (4-3) | 42-73 | |
| » W: Glenn Abbott (5-9) L: Roger Erickson (11-7) S: Jim Todd (2) | Seventh | 22½ out |
| Friday, August 11 |
| » Lost to Angels (64-53), 3-1 | Kingdome (23-36) | 42-74 | |
| » W: Nolan Ryan (6-10) L: Byron McLaughlin (0-4) | Seventh | 23 out |
| Saturday, August 12 |
| » Lost to Angels (65-53), 7-5 | Kingdome (23-37) | 42-75 | Lost 2 |
| » W: Dave LaRoche (9-5) L: Jim Todd (2-4) | Seventh | 22½ out |
| » Defeated Angels (65-54), 5-3 | Kingdome (24-37) | 43-75 | |
| » W: Paul Mitchell (6-11) L: Chris Knapp (11-7) S: Mike Parrott (1) | Seventh | 22½ out |
| Sunday, August 13 |
| » Defeated Angels (65-55), 4-1 | Kingdome (25-37) | 44-75 | Won 2 |
| » W: Rick Honeycutt (5-7) L: Paul Hartzell (4-7) | Seventh | 21½ out |
| Tuesday, August 15 |
| » Lost to Orioles (64-54), 7-4 | Kingdome (25-38) | 44-76 | |
| » W: Dennis Martinez (9-10) L: Glenn Abbott (5-10) S: Don Stanhouse (18) | Seventh | 22 out |
| Wednesday, August 16 |
| » Defeated Orioles (64-55), 7-5 | Kingdome (26-38) | 45-76 | |
| » W: Byron McLaughlin (1-4) L: Mike Flanagan (15-11) S: Jim Todd (3) | Seventh | 21½ out |
| Friday, August 18 |
| » Lost to Yankees (69-51), 6-1 | Kingdome (26-39) | 45-77 | |
| » W: Ed Figueroa (12-8) L: Paul Mitchell (6-12) | Seventh | 21 out |
| Saturday, August 19 |
| » Defeated Yankees (69-52), 4-1 | Kingdome (27-39) | 46-77 | |
| » W: Jim Colborn (4-8) L: Dick Tidrow (5-9) | Seventh | 21 out |
| Sunday, August 20 |
| » Defeated Yankees (69-53), 5-4 | Kingdome (28-39) | 47-77 | Won 2 |
| » W: Enrique Romo (10-4) L: Rich Gossage (8-10) | Seventh | 21 out |
| Tuesday, August 22 |
| » Defeated Red Sox (78-46), 5-2 | Kingdome (29-39) | 48-77 | Won 3 |
| » W: Glenn Abbott (6-10) L: Luis Tiant (9-6) | Seventh | 21 out |
| Wednesday, August 23 |
| » Defeated Red Sox (78-47), 5-3 | Kingdome (30-39) | 49-77 | Won 4 |
| » W: Byron McLaughlin (2-4) L: Mike Torrez (15-7) S: Enrique Romo (10) | Seventh | 20 out |
| Friday, August 25 |
| » Lost to Orioles (68-58), 5-0 | Memorial Stadium (0-3) | 49-78 | |
| » W: Dennis Martinez (10-10) L: Paul Mitchell (6-13) | Seventh | 20 out |
| Saturday, August 26 |
| » Lost to Orioles (69-58), 9-2 | Memorial Stadium (0-4) | 49-79 | Lost 2 |
| » W: Mike Flanagan (17-11) L: Jim Colborn (4-9) S: Joe Kerrigan (2) | Seventh | 20 out |
| Sunday, August 27 |
| » Lost to Orioles (70-58), 4-3 | Memorial Stadium (0-5) | 49-80 | Lost 3 |
| » W: Nelson Briles (3-4) L: Enrique Romo (10-5) | Seventh | 20½ out |
| Monday, August 28 |
| » Lost to Red Sox (82-47), 10-9 | Fenway Park (1-3) | 49-81 | Lost 4 |
| » W: Bob Stanley (12-1) L: Enrique Romo (10-6) | Seventh | 21½ out |
| Tuesday, August 29 |
| » Lost to Red Sox (83-47), 10-5 | Fenway Park (1-4) | 49-82 | Lost 5 |
| » W: Dick Drago (3-4) L: Byron McLaughlin (2-5) S: Tom Burgmeier (4) | Seventh | 21½ out |
| Friday, September 1 |
| » Defeated Yankees (77-55), 3-0 | Yankee Stadium (1-2) | 50-82 | |
| » W: Paul Mitchell (7-13) L: Catfish Hunter (9-5) | Seventh | 21 out |
| Saturday, September 2 |
| » Lost to Yankees (78-55), 6-2 | Yankee Stadium (1-3) | 50-83 | |
| » W: Ed Figueroa (14-9) L: Jim Colborn (4-10) | Seventh | 22 out |
| Sunday, September 3 |
| » Lost to Yankees (79-55), 4-3 | Yankee Stadium (1-4) | 50-84 | Lost 2 |
| » W: Jim Beattie (3-7) L: Rick Honeycutt (5-8) S: Rich Gossage (21) | Seventh | 23 out |
| Monday, September 4 |
| » Defeated Brewers (78-59), 4-3 | County Stadium (3-1) | 51-84 | |
| » W: Glenn Abbott (7-10) L: Mike Caldwell (17-9) | Seventh | 23½ out |
| » Lost to Brewers (79-59), 5-0 | County Stadium (3-2) | 51-85 | |
| » W: Bill Travers (10-8) L: Byron McLaughlin (2-6) | Seventh | 23½ out |
| Thursday, September 7 |
| » Defeated White Sox (59-81), 5-3 | Comiskey Park I (4-0) | 52-85 | |
| » W: Paul Mitchell (8-13) L: Steve Stone (10-12) | Seventh | 24 out |
| » Major-league debuts: Harry Chappas (White Sox) |
| Friday, September 8 |
| » Lost to White Sox (60-81), 3-2 | Comiskey Park I (4-1) | 52-86 | |
| » W: Rich Wortham (2-2) L: Jim Colborn (4-11) | Seventh | 25 out |
| Future Mariner Gil Meche is born in Lafayette, LA. |
| Saturday, September 9 |
| » Defeated White Sox (60-82), 9-6 | Comiskey Park I (5-1) | 53-86 | |
| » W: Enrique Romo (11-6) L: Lerrin LaGrow (4-5) | Seventh | 23½ out |
| Sunday, September 10 |
| » Lost to White Sox (61-82), 2-1 | Comiskey Park I (5-2) | 53-87 | |
| » W: Jack Kucek (1-2) L: Glenn Abbott (7-11) | Seventh | 23½ out |
| Monday, September 11 |
| » Lost to Brewers (83-61), 5-3 | Kingdome (30-40) | 53-88 | Lost 2 |
| » W: Lary Sorensen (17-10) L: Byron McLaughlin (2-7) S: Bill Castro (6) | Seventh | 24½ out |
| Tuesday, September 12 |
| » Defeated Brewers (83-62), 6-5 | Kingdome (31-40) | 54-88 | |
| » W: Jim Todd (3-4) L: Bob McClure (2-6) | Seventh | 24½ out |
| » Major-league debuts: Mark Bomback (Brewers) |
| Thursday, September 14 |
| » Lost to White Sox (63-83), 6-5 | Kingdome (31-41) | 54-89 | |
| » W: Steve Stone (11-12) L: Rick Honeycutt (5-9) | Seventh | 26 out |
| » Major-league debuts: Tom Brown (Mariners) |
| Friday, September 15 |
| » Lost to White Sox (64-83), 8-3 | Kingdome (31-42) | 54-90 | Lost 2 |
| » W: Rich Wortham (3-2) L: Enrique Romo (11-7) | Seventh | 27 out |
| Saturday, September 16 |
| » Lost to White Sox (65-83), 9-1 | Kingdome (31-43) | 54-91 | Lost 3 |
| » W: Francisco Barrios (9-13) L: Glenn Abbott (7-12) | Seventh | 27 out |
| Sunday, September 17 |
| » Defeated White Sox (65-84), 3-1 | Kingdome (32-43) | 55-91 | |
| » W: Byron McLaughlin (3-7) L: Jack Kucek (1-3) | Seventh | 27 out |
| Monday, September 18 |
| » Lost to Royals (84-65), 7-6 | Kingdome (32-44) | 55-92 | |
| » W: Doug Bird (6-6) L: Mike Parrott (1-4) S: Al Hrabosky (19) | Seventh | 28 out |
| Tuesday, September 19 |
| » Lost to Royals (85-65), 9-8 | Kingdome (32-45) | 55-93 | Lost 2 |
| » W: Paul Splittorff (18-12) L: Rick Honeycutt (5-10) | Seventh | 29 out |
| Friday, September 22 |
| » Lost to Rangers (77-74), 10-2 | Arlington Stadium (1-2) | 55-94 | Lost 3 |
| » W: Doc Medich (9-8) L: Glenn Abbott (7-13) | Seventh | 30 out |
| » Lost to Rangers (78-74), 1-0 | Arlington Stadium (1-3) | 55-95 | Lost 4 |
| » W: Fergie Jenkins (17-8) L: Byron McLaughlin (3-8) | Seventh | 30 out |
| Saturday, September 23 |
| » Lost to Rangers (79-74), 7-2 | Arlington Stadium (1-4) | 55-96 | Lost 5 |
| » W: Doyle Alexander (9-10) L: Paul Mitchell (8-14) | Seventh | 31 out |
| Sunday, September 24 |
| » Lost to Rangers (80-74), 5-3 | Arlington Stadium (1-5) | 55-97 | Lost 6 |
| » W: Steve Comer (10-5) L: Jim Colborn (4-12) S: Paul Mirabella (1) | Seventh | 31½ out |
| » Lost to Rangers (81-74), 4-3 | Arlington Stadium (1-6) | 55-98 | Lost 7 |
| » W: Danny Darwin (1-0) L: Rick Jones (0-1) S: Jim Umbarger (1) | Seventh | 31½ out |
| Monday, September 25 |
| » Lost to Royals (89-68), 7-2 | Royals Stadium (0-6) | 55-99 | Lost 8 |
| » W: Dennis Leonard (20-17) L: Rick Honeycutt (5-11) | Seventh | 32½ out |
| Future Mariner Joel Pineiro is born in Rio Pedres, P.R. |
| Tuesday, September 26 |
| » Lost to Royals (90-68), 4-1 | Royals Stadium (0-7) | 55-100 | Lost 9 |
| » W: Larry Gura (16-4) L: Glenn Abbott (7-14) | Seventh | 33½ out |
| Wednesday, September 27 |
| » Defeated Royals (90-69), 4-2 | Royals Stadium (1-7) | 56-100 | |
| » W: Byron McLaughlin (4-8) L: Paul Splittorff (19-13) | Seventh | 32½ out |
| Thursday, September 28 |
| » Lost to Rangers (84-75), 4-3 | Kingdome (32-46) | 56-101 | |
| » W: Jim Umbarger (5-8) L: Shane Rawley (4-9) | Seventh | 33 out |
| Friday, September 29 |
| » Lost to Rangers (85-75), 11-4 | Kingdome (32-47) | 56-102 | Lost 2 |
| » W: Steve Comer (11-5) L: Mike Parrott (1-5) | Seventh | 34 out |
| Saturday, September 30 |
| » Lost to Rangers (86-75), 4-1 | Kingdome (32-48) | 56-103 | Lost 3 |
| » W: Jon Matlack (15-13) L: Rick Jones (0-2) | Sixth | 34 out |
| Sunday, October 1 |
| » Lost to Rangers (87-75), 9-4 | Kingdome (32-49) | 56-104 | Lost 4 |
| » W: Fergie Jenkins (18-8) L: Glenn Abbott (7-15) | Sixth | 35 out |
Game information provided by Retrosheet (www.retrosheet.org) |