| Wednesday, January 4 |
| Future Indian Willie Martinez is born in Barquisimeto, Venezuela. Former Indian Joe Dawson dies in Longview, TX at the age of 81. |
| Saturday, January 7 |
| Former Indian George Burns dies in Kirkland, WA at the age of 85. |
| Thursday, January 19 |
| Former Indian Milt Shoffner dies in Madison, OH at the age of 73. |
| Friday, January 27 |
| Former Indian Sarge Connally dies in Temple, TX at the age of 80. Former Indian Monte Pearson dies in Fresno, CA at the age of 70. |
| Saturday, January 28 |
| Former Indian Larry Raines dies in Lansing, MI at the age of 48. |
| Saturday, February 4 |
| Former Indian Dave Keefe dies in Kansas City, MO at the age of 82. |
| Thursday, March 9 |
| Former Indian Bill Doran dies in Santa Monica, CA at the age of 80. |
| Tuesday, March 21 |
| Former Indian Fritz Coumbe dies in Paradise, CA at the age of 89. |
| Thursday, March 30 |
| Future Indian Josh Bard is born in Ithaca, NY. |
| Wednesday, April 5 |
| » Major-league debuts: Hosken Powell (Twins) |
| Friday, April 7 |
| » Major-league debuts: Paul Molitor (Brewers) |
| Saturday, April 8 |
| » Defeated Royals (0-1), 8-5 | Cleveland Stadium (1-0) | 1-0 | |
| » W: Wayne Garland (1-0) L: Dennis Leonard (0-1) S: Mike Paxton (1) | Second | ½ out |
| Sunday, April 9 |
| » Lost to Royals (1-1), 5-4 | Cleveland Stadium (1-1) | 1-1 | |
| » W: Steve Busby (1-0) L: Rick Wise (0-1) S: Steve Mingori (1) | Third | 1½ out |
| » Major-league debuts: Dennis Kinney (Indians) |
| Monday, April 10 |
| » Defeated Red Sox (1-3), 5-4 | Cleveland Stadium (2-1) | 2-1 | |
| » W: Jim Kern (1-0) L: Reggie Cleveland (0-1) | Second | 1 out |
| » Major-league debuts: Allen Ripley (Red Sox) |
| Tuesday, April 11 |
| » Major-league debuts: Andy Replogle (Brewers) |
| Wednesday, April 12 |
| » Lost to Red Sox (2-3), 6-3 | Cleveland Stadium (2-2) | 2-2 | |
| » W: Mike Torrez (1-0) L: Wayne Garland (1-1) S: Dick Drago (1) | Third | 2½ out |
| Friday, April 14 |
| » Lost to Royals (4-1), 3-1 | Royals Stadium (0-1) | 2-3 | Lost 2 |
| » W: Paul Splittorff (2-0) L: Rick Wise (0-2) S: Doug Bird (1) | Fourth | 2½ out |
| Former Indian Joe Gordon dies in Sacramento, CA at the age of 64. |
| Saturday, April 15 |
| » Lost to Royals (5-1), 6-5 | Royals Stadium (0-2) | 2-4 | Lost 3 |
| » W: Marty Pattin (1-0) L: Mike Paxton (0-1) S: Al Hrabosky (2) | Fourth | 2½ out |
| Future Indian Milton Bradley is born in Harbor City, CA. |
| Sunday, April 16 |
| » Lost to Royals (6-1), 2-1 | Royals Stadium (0-3) | 2-5 | Lost 4 |
| » W: Dennis Leonard (2-1) L: Wayne Garland (1-2) | Sixth | 3½ out |
| Monday, April 17 |
| » Defeated Rangers (2-7), 6-0 | Cleveland Stadium (3-2) | 3-5 | |
| » W: Rick Waits (1-0) L: Jon Matlack (1-2) | Sixth | 3½ out |
| Thursday, April 20 |
| Former Indian Jack Graney dies in Louisiana, MO at the age of 92. |
| Friday, April 21 |
| » Lost to Red Sox (9-3), 9-7 | Fenway Park (0-1) | 3-6 | |
| » W: Dick Drago (2-1) L: Jim Kern (1-1) | Fifth | 4 out |
| Saturday, April 22 |
| » Defeated Red Sox (9-4), 13-4 | Fenway Park (1-1) | 4-6 | |
| » W: Rick Wise (1-2) L: Allen Ripley (0-1) | Fifth | 4 out |
| » Major-league debuts: Wayne Cage (Indians) |
| Sunday, April 23 |
| » Lost to Red Sox (10-4), 6-3 | Fenway Park (1-2) | 4-7 | |
| » W: Bill Campbell (1-1) L: Dennis Kinney (0-1) | Fifth | 4 out |
| » Defeated Red Sox (10-5), 10-7 | Fenway Park (2-2) | 5-7 | |
| » W: Jim Kern (2-1) L: Bob Stanley (1-1) S: Dennis Kinney (1) | Fifth | 4 out |
| » Major-league debuts: Ron Hassey (Indians) |
| Monday, April 24 |
| » Defeated Blue Jays (5-10), 4-2 | Exhibition Stadium (1-0) | 6-7 | Won 2 |
| » W: Don Hood (1-0) L: Dave Lemanczyk (0-4) S: Jim Kern (1) | Fifth | 4 out |
| Tuesday, April 25 |
| » Defeated Blue Jays (5-11), 6-5 | Exhibition Stadium (2-0) | 7-7 | Won 3 |
| » W: Wayne Garland (2-2) L: Jerry Garvin (1-1) S: Dennis Kinney (2) | Third | 4 out |
| Wednesday, April 26 |
| » Lost to Rangers (5-10), 3-0 | Arlington Stadium (0-1) | 7-8 | |
| » W: Doyle Alexander (1-1) L: Rick Wise (1-3) | Fifth | 4 out |
| Thursday, April 27 |
| » Lost to Rangers (6-10), 3-1 | Arlington Stadium (0-2) | 7-9 | Lost 2 |
| » W: Jon Matlack (2-3) L: Rick Waits (1-1) S: Len Barker (1) | Fifth | 4½ out |
| Friday, April 28 |
| » Defeated Athletics (14-5), 6-2 | Oakland-Alameda County Stadium (1-0) | 8-9 | |
| » W: Don Hood (2-0) L: John Henry Johnson (2-1) | Fifth | 4½ out |
| Saturday, April 29 |
| » Lost to Athletics (15-5), 5-1 | Oakland-Alameda County Stadium (1-1) | 8-10 | |
| » W: Pete Broberg (3-0) L: Wayne Garland (2-3) S: Bob Lacey (1) | Fifth | 5½ out |
| Sunday, April 30 |
| » Lost to Athletics (16-5), 2-1 | Oakland-Alameda County Stadium (1-2) | 8-11 | Lost 2 |
| » W: Elias Sosa (3-0) L: Rick Wise (1-4) | Fifth | 5½ out |
| Tuesday, May 2 |
| » Defeated Mariners (8-19), 4-1 | Kingdome (1-0) | 9-11 | |
| » W: Rick Waits (2-1) L: Dick Pole (2-4) S: Jim Kern (2) | Fourth | 5½ out |
| Wednesday, May 3 |
| » Defeated Mariners (8-20), 10-5 | Kingdome (2-0) | 10-11 | Won 2 |
| » W: Don Hood (3-0) L: Byron McLaughlin (0-2) S: Dennis Kinney (3) | Fourth | 5½ out |
| Friday, May 5 |
| » Lost to Angels (15-9), 5-0 | Anaheim Stadium (0-1) | 10-12 | |
| » W: Nolan Ryan (2-1) L: Rick Wise (1-5) | Fifth | 5½ out |
| Saturday, May 6 |
| » Lost to Angels (16-9), 7-3 | Anaheim Stadium (0-2) | 10-13 | Lost 2 |
| » W: Chris Knapp (4-2) L: Mike Paxton (0-2) | Fifth | 6½ out |
| Sunday, May 7 |
| » Lost to Angels (17-9), 16-3 | Anaheim Stadium (0-3) | 10-14 | Lost 3 |
| » W: Don Aase (2-1) L: Rick Waits (2-2) S: Paul Hartzell (4) | Fifth | 7½ out |
| Tuesday, May 9 |
| » Defeated Mariners (11-21), 5-4 | Cleveland Stadium (4-2) | 11-14 | |
| » W: Jim Kern (3-1) L: Shane Rawley (0-2) | Fifth | 6½ out |
| Wednesday, May 10 |
| » Defeated Mariners (11-22), 6-1 | Cleveland Stadium (5-2) | 12-14 | Won 2 |
| » W: Rick Wise (2-5) L: Rick Honeycutt (2-4) S: Dennis Kinney (4) | Fourth | 6 out |
| Friday, May 12 |
| » Defeated Angels (18-10), 4-3 | Cleveland Stadium (6-2) | 13-14 | Won 3 |
| » W: Mike Paxton (1-2) L: Nolan Ryan (2-2) S: Jim Kern (3) | Fourth | 5 out |
| Saturday, May 13 |
| » Defeated Angels (18-11), 2-1 | Cleveland Stadium (7-2) | 14-14 | Won 4 |
| » W: Rick Waits (3-2) L: Chris Knapp (4-3) | Fourth | 5 out |
| Sunday, May 14 |
| » Lost to Angels (19-11), 4-3 | Cleveland Stadium (7-3) | 14-15 | |
| » W: Frank Tanana (6-1) L: Don Hood (3-1) S: Paul Hartzell (5) | Fourth | 6 out |
| Monday, May 15 |
| » Lost to Athletics (22-10), 3-2 | Cleveland Stadium (7-4) | 14-16 | Lost 2 |
| » W: Joe Coleman (3-0) L: Rick Wise (2-6) S: Elias Sosa (6) | Fourth | 6 out |
| Tuesday, May 16 |
| » Defeated Athletics (22-11), 3-2 | Cleveland Stadium (8-4) | 15-16 | |
| » W: David Clyde (1-0) L: Bob Lacey (3-1) | Fourth | 6 out |
| Wednesday, May 17 |
| » Defeated Yankees (19-13), 5-4 | Cleveland Stadium (9-4) | 16-16 | Won 2 |
| » W: Sid Monge (1-0) L: Sparky Lyle (2-1) | Fourth | 6 out |
| Thursday, May 18 |
| » Lost to Yankees (20-13), 5-3 | Cleveland Stadium (9-5) | 16-17 | |
| » W: Ron Guidry (5-0) L: Dennis Kinney (0-2) S: Rich Gossage (5) | Fourth | 6 out |
| Friday, May 19 |
| » Defeated Orioles (14-20), 7-5 | Cleveland Stadium (10-5) | 17-17 | |
| » W: Jim Kern (4-1) L: Don Stanhouse (0-3) | Fourth | 6 out |
| Saturday, May 20 |
| » Lost to Orioles (15-20), 2-1 | Cleveland Stadium (10-6) | 17-18 | |
| » W: Jim Palmer (4-4) L: Rick Wise (2-7) S: Don Stanhouse (7) | Fourth | 6 out |
| Sunday, May 21 |
| » Lost to Orioles (16-20), 3-0 | Cleveland Stadium (10-7) | 17-19 | Lost 2 |
| » W: Scott McGregor (3-3) L: Rick Waits (3-3) | Fourth | 6 out |
| » Defeated Orioles (16-21), 3-2 | Cleveland Stadium (11-7) | 18-19 | |
| » W: David Clyde (2-0) L: Nelson Briles (1-3) S: Dennis Kinney (5) | Fourth | 6 out |
| Future Indian Ricardo Rodriguez is born in Guayubin, D.R. |
| Tuesday, May 23 |
| » Lost to Yankees (24-14), 10-1 | Yankee Stadium (0-1) | 18-20 | |
| » W: Ron Guidry (6-0) L: Don Hood (3-2) | Fifth | 6 out |
| Thursday, May 25 |
| » Lost to Yankees (25-14), 9-3 | Yankee Stadium (0-2) | 18-21 | Lost 2 |
| » W: Dick Tidrow (3-3) L: Rick Waits (3-4) | Sixth | 8 out |
| Friday, May 26 |
| » Lost to Orioles (20-22), 4-3 | Memorial Stadium (0-1) | 18-22 | Lost 3 |
| » W: Tippy Martinez (1-1) L: Rick Wise (2-8) | Sixth | 9 out |
| Saturday, May 27 |
| » Defeated Orioles (20-23), 6-2 | Memorial Stadium (1-1) | 19-22 | |
| » W: David Clyde (3-0) L: Mike Flanagan (5-4) | Sixth | 9 out |
| Sunday, May 28 |
| » Defeated Orioles (20-24), 4-3 | Memorial Stadium (2-1) | 20-22 | Won 2 |
| » W: Sid Monge (2-0) L: Don Stanhouse (0-4) | Sixth | 10 out |
| » Lost to Orioles (21-24), 3-0 | Memorial Stadium (2-2) | 20-23 | |
| » W: Jim Palmer (6-4) L: Mike Paxton (1-3) | Sixth | 10 out |
| Monday, May 29 |
| » Lost to Yankees (29-15), 2-0 | Cleveland Stadium (11-8) | 20-24 | Lost 2 |
| » W: Rawly Eastwick (2-0) L: Rick Waits (3-5) | Sixth | 11 out |
| Tuesday, May 30 |
| » Defeated Yankees (29-16), 5-1 | Cleveland Stadium (12-8) | 21-24 | |
| » W: Rick Wise (3-8) L: Dick Tidrow (3-4) | Sixth | 11 out |
| Friday, June 2 |
| » Defeated Brewers (23-24), 7-6 | County Stadium (1-0) | 22-24 | Won 2 |
| » W: Jim Kern (5-1) L: Bob McClure (0-2) | Sixth | 10½ out |
| Saturday, June 3 |
| » Defeated Brewers (23-25), 6-4 | County Stadium (2-0) | 23-24 | Won 3 |
| » W: Mike Paxton (2-3) L: Jerry Augustine (5-8) S: Sid Monge (1) | Fifth | 10½ out |
| Sunday, June 4 |
| » Lost to Brewers (24-25), 12-7 | County Stadium (2-1) | 23-25 | |
| » W: Randy Stein (1-1) L: Rick Wise (3-9) | Sixth | 11 out |
| » Lost to Brewers (25-25), 9-4 | County Stadium (2-2) | 23-26 | Lost 2 |
| » W: Bill Travers (2-2) L: Don Hood (3-3) S: Bill Castro (2) | Sixth | 11 out |
| Monday, June 5 |
| » Lost to White Sox (20-29), 2-0 | Cleveland Stadium (12-9) | 23-27 | Lost 3 |
| » W: Steve Stone (5-3) L: Rick Waits (3-6) | Sixth | 11 out |
| Tuesday, June 6 |
| » Lost to White Sox (21-29), 3-0 | Cleveland Stadium (12-10) | 23-28 | Lost 4 |
| » W: Francisco Barrios (4-5) L: Sid Monge (2-1) | Sixth | 11 out |
| Friday, June 9 |
| » Defeated Twins (21-33), 7-3 | Cleveland Stadium (13-10) | 24-28 | |
| » W: David Clyde (4-0) L: Geoff Zahn (5-4) S: Jim Kern (4) | Sixth | 11 out |
| Saturday, June 10 |
| » Defeated Twins (21-34), 4-3 | Cleveland Stadium (14-10) | 25-28 | Won 2 |
| » W: Rick Wise (4-9) L: Mike Marshall (1-4) S: Jim Kern (5) | Sixth | 11 out |
| Sunday, June 11 |
| » Defeated Twins (21-35), 2-1 | Cleveland Stadium (15-10) | 26-28 | Won 3 |
| » W: Mike Paxton (3-3) L: Mike Marshall (1-5) | Sixth | 11 out |
| Monday, June 12 |
| » Lost to White Sox (26-30), 1-0 | Comiskey Park I (0-1) | 26-29 | |
| » W: Ken Kravec (5-4) L: Rick Waits (3-7) S: Jim Willoughby (6) | Sixth | 12 out |
| Tuesday, June 13 |
| » Lost to White Sox (27-30), 10-9 | Comiskey Park I (0-2) | 26-30 | Lost 2 |
| » W: Rich Hinton (1-0) L: Al Fitzmorris (0-1) S: Lerrin LaGrow (6) | Sixth | 13 out |
| Wednesday, June 14 |
| » Lost to Twins (24-35), 8-2 | Metropolitan Stadium (0-1) | 26-31 | Lost 3 |
| » W: Roger Erickson (7-4) L: David Clyde (4-1) | Sixth | 14 out |
| Friday, June 16 |
| » Lost to Brewers (35-26), 8-6 | Cleveland Stadium (15-11) | 26-32 | Lost 4 |
| » W: Bob McClure (2-2) L: Jim Kern (5-2) S: Bill Castro (3) | Sixth | 15½ out |
| Saturday, June 17 |
| » Lost to Brewers (36-26), 4-3 | Cleveland Stadium (15-12) | 26-33 | Lost 5 |
| » W: Bill Castro (3-0) L: Jim Kern (5-3) | Sixth | 16½ out |
| Sunday, June 18 |
| » Defeated Brewers (36-27), 3-0 | Cleveland Stadium (16-12) | 27-33 | |
| » W: Rick Waits (4-7) L: Mike Caldwell (7-4) | Sixth | 16 out |
| » Lost to Brewers (37-27), 4-1 | Cleveland Stadium (16-13) | 27-34 | |
| » W: Jerry Augustine (7-8) L: Mike Paxton (3-4) S: Bill Castro (4) | Sixth | 16 out |
| Monday, June 19 |
| » Lost to Royals (34-29), 6-5 | Royals Stadium (0-4) | 27-35 | Lost 2 |
| » W: Dennis Leonard (7-9) L: David Clyde (4-2) S: Al Hrabosky (9) | Fifth | 17 out |
| Tuesday, June 20 |
| » Lost to Royals (35-29), 3-2 | Royals Stadium (0-5) | 27-36 | Lost 3 |
| » W: Larry Gura (5-1) L: Rick Wise (4-10) | Sixth | 17 out |
| Wednesday, June 21 |
| » Defeated Royals (35-30), 4-2 | Royals Stadium (1-5) | 28-36 | |
| » W: Dan Spillner (2-0) L: Doug Bird (3-3) S: Jim Kern (6) | Fifth | 17 out |
| Friday, June 23 |
| » Defeated Blue Jays (21-45), 8-3 | Cleveland Stadium (17-13) | 29-36 | Won 2 |
| » W: Rick Waits (5-7) L: Jesse Jefferson (5-7) | Fifth | 17 out |
| » Major-league debuts: Brian Milner (Blue Jays) |
| Saturday, June 24 |
| » Defeated Blue Jays (21-46), 12-3 | Cleveland Stadium (18-13) | 30-36 | Won 3 |
| » W: Mike Paxton (4-4) L: Jim Clancy (4-7) | Fifth | 17 out |
| » Major-league debuts: Victor Cruz (Blue Jays) |
| Sunday, June 25 |
| » Lost to Blue Jays (22-46), 2-1 | Cleveland Stadium (18-14) | 30-37 | |
| » W: Balor Moore (3-1) L: David Clyde (4-3) S: Victor Cruz (1) | Sixth | 17½ out |
| » Defeated Blue Jays (22-47), 3-2 | Cleveland Stadium (19-14) | 31-37 | |
| » W: Rick Wise (5-10) L: Jerry Garvin (2-7) S: Sid Monge (2) | Sixth | 17½ out |
| Monday, June 26 |
| » Defeated Tigers (34-35), 5-4 | Cleveland Stadium (20-14) | 32-37 | Won 2 |
| » W: Don Hood (4-3) L: Jack Billingham (5-5) S: Dan Spillner (1) | Fifth | 17½ out |
| Tuesday, June 27 |
| » Lost to Tigers (35-35), 6-1 | Cleveland Stadium (20-15) | 32-38 | |
| » W: Dave Rozema (3-4) L: Dave Freisleben (0-4) | Sixth | 17½ out |
| Wednesday, June 28 |
| » Lost to Tigers (36-35), 4-3 | Cleveland Stadium (20-16) | 32-39 | Lost 2 |
| » W: Jim Slaton (8-4) L: Rick Waits (5-8) S: John Hiller (8) | Sixth | 17½ out |
| » Defeated Tigers (36-36), 2-1 | Cleveland Stadium (21-16) | 33-39 | |
| » W: Mike Paxton (5-4) L: Milt Wilcox (4-7) S: Sid Monge (3) | Sixth | 17½ out |
| Thursday, June 29 |
| » Defeated Tigers (36-37), 6-3 | Cleveland Stadium (22-16) | 34-39 | Won 2 |
| » W: Jim Kern (6-3) L: Jack Morris (1-3) | Sixth | 17½ out |
| Friday, June 30 |
| » Defeated Blue Jays (26-48), 3-0 | Exhibition Stadium (3-0) | 35-39 | Won 3 |
| » W: Rick Wise (6-10) L: Jerry Garvin (2-8) | Sixth | 16½ out |
| Saturday, July 1 |
| » Lost to Blue Jays (27-48), 9-3 | Exhibition Stadium (3-1) | 35-40 | |
| » W: Tom Underwood (5-7) L: Don Hood (4-4) S: Victor Cruz (3) | Sixth | 16½ out |
| Sunday, July 2 |
| » Defeated Blue Jays (27-49), 2-0 | Exhibition Stadium (4-1) | 36-40 | |
| » W: Rick Waits (6-8) L: Dave Lemanczyk (2-10) S: Jim Kern (7) | Sixth | 16½ out |
| » Lost to Blue Jays (28-49), 3-1 | Exhibition Stadium (4-2) | 36-41 | |
| » W: Jesse Jefferson (6-7) L: Dave Freisleben (0-5) | Sixth | 16½ out |
| Monday, July 3 |
| » Defeated Orioles (42-36), 9-0 | Cleveland Stadium (23-16) | 37-41 | |
| » W: Mike Paxton (6-4) L: Scott McGregor (8-7) | Sixth | 16½ out |
| Tuesday, July 4 |
| » Lost to Orioles (43-36), 6-4 | Cleveland Stadium (23-17) | 37-42 | |
| » W: Dennis Martinez (7-6) L: David Clyde (4-4) S: Don Stanhouse (12) | Fifth | 17 out |
| Wednesday, July 5 |
| » Lost to Tigers (39-41), 13-3 | Tiger Stadium (0-1) | 37-43 | Lost 2 |
| » W: Jack Billingham (7-5) L: Rick Wise (6-11) | Fifth | 18 out |
| Thursday, July 6 |
| » Lost to Tigers (40-41), 8-4 | Tiger Stadium (0-2) | 37-44 | Lost 3 |
| » W: Bob Sykes (4-4) L: Rick Waits (6-9) S: John Hiller (9) | Sixth | 19 out |
| Friday, July 7 |
| » Defeated Red Sox (55-25), 10-9 | Cleveland Stadium (24-17) | 38-44 | |
| » W: Dan Spillner (3-0) L: Bill Campbell (5-5) | Sixth | 18 out |
| Saturday, July 8 |
| » Lost to Red Sox (56-25), 12-5 | Cleveland Stadium (24-18) | 38-45 | |
| » W: Dennis Eckersley (10-2) L: Mike Paxton (6-5) | Sixth | 20 out |
| » Lost to Red Sox (57-25), 3-2 | Cleveland Stadium (24-19) | 38-46 | Lost 2 |
| » W: Jim Wright (4-1) L: David Clyde (4-5) S: Bob Stanley (5) | Sixth | 20 out |
| Sunday, July 9 |
| » Defeated Red Sox (57-26), 7-1 | Cleveland Stadium (25-19) | 39-46 | |
| » W: Rick Wise (7-11) L: Allen Ripley (2-5) | Sixth | 19 out |
| Thursday, July 13 |
| » Lost to Athletics (44-44), 7-3 | Oakland-Alameda County Stadium (1-3) | 39-47 | |
| » W: John Henry Johnson (6-5) L: Rick Waits (6-10) S: Dave Heaverlo (6) | Sixth | 19 out |
| Friday, July 14 |
| » Defeated Athletics (44-45), 11-1 | Oakland-Alameda County Stadium (2-3) | 40-47 | |
| » W: Rick Wise (8-11) L: Matt Keough (6-5) | Sixth | 18 out |
| Saturday, July 15 |
| » Lost to Mariners (32-59), 7-6 | Kingdome (2-1) | 40-48 | |
| » W: Enrique Romo (8-2) L: Mike Paxton (6-6) | Sixth | 19 out |
| Sunday, July 16 |
| » Defeated Mariners (32-60), 8-4 | Kingdome (3-1) | 41-48 | |
| » W: David Clyde (5-5) L: Paul Mitchell (5-9) S: Sid Monge (4) | Sixth | 19½ out |
| Monday, July 17 |
| » Defeated Mariners (32-61), 5-2 | Kingdome (4-1) | 42-48 | Won 2 |
| » W: Dave Freisleben (1-5) L: Jim Colborn (1-8) S: Sid Monge (5) | Sixth | 19½ out |
| Tuesday, July 18 |
| » Defeated Angels (49-43), 8-3 | Anaheim Stadium (1-3) | 43-48 | Won 3 |
| » W: Rick Waits (7-10) L: Don Aase (7-5) S: Jim Kern (8) | Sixth | 19 out |
| Wednesday, July 19 |
| » Lost to Angels (50-43), 3-0 | Anaheim Stadium (1-4) | 43-49 | |
| » W: Nolan Ryan (4-8) L: Rick Wise (8-12) | Sixth | 20 out |
| Friday, July 21 |
| » Defeated Mariners (33-63), 11-0 | Cleveland Stadium (26-19) | 44-49 | |
| » W: Mike Paxton (7-6) L: Mike Parrott (1-2) | Sixth | 18½ out |
| Saturday, July 22 |
| » Defeated Mariners (33-64), 8-5 | Cleveland Stadium (27-19) | 45-49 | Won 2 |
| » W: Paul Reuschel (3-0) L: Paul Mitchell (5-10) | Sixth | 17½ out |
| Monday, July 24 |
| » Lost to Angels (53-46), 5-4 | Cleveland Stadium (27-20) | 45-50 | |
| » W: Tom Griffin (2-3) L: Jim Kern (6-4) | Sixth | 17½ out |
| Tuesday, July 25 |
| » Defeated Angels (53-47), 5-1 | Cleveland Stadium (28-20) | 46-50 | |
| » W: Mike Paxton (8-6) L: Dave Frost (2-4) S: Dan Spillner (2) | Sixth | 16½ out |
| Wednesday, July 26 |
| » Lost to Yankees (54-43), 3-1 | Yankee Stadium (0-3) | 46-51 | |
| » W: Rich Gossage (6-9) L: Rick Waits (7-11) | Sixth | 16½ out |
| Thursday, July 27 |
| » Lost to Yankees (55-43), 11-0 | Yankee Stadium (0-4) | 46-52 | Lost 2 |
| » W: Ed Figueroa (10-7) L: David Clyde (5-6) | Sixth | 16 out |
| » Defeated Yankees (55-44), 17-5 | Yankee Stadium (1-4) | 47-52 | |
| » W: Don Hood (5-4) L: Catfish Hunter (3-4) | Sixth | 16 out |
| Friday, July 28 |
| » Defeated Athletics (52-51), 4-2 | Cleveland Stadium (29-20) | 48-52 | Won 2 |
| » W: Jim Kern (7-4) L: Pete Broberg (9-8) | Sixth | 15 out |
| Saturday, July 29 |
| » Lost to Athletics (53-51), 6-5 | Cleveland Stadium (29-21) | 48-53 | |
| » W: Steve Renko (5-5) L: Rick Wise (8-13) S: Dave Heaverlo (9) | Sixth | 16 out |
| Sunday, July 30 |
| » Lost to Athletics (54-51), 5-4 | Cleveland Stadium (29-22) | 48-54 | Lost 2 |
| » W: Elias Sosa (8-2) L: Jim Kern (7-5) | Fifth | 16 out |
| Monday, July 31 |
| » Defeated Royals (58-44), 4-3 | Cleveland Stadium (30-22) | 49-54 | |
| » W: Sid Monge (3-1) L: Al Hrabosky (4-4) | Fifth | 16 out |
| Tuesday, August 1 |
| » Defeated Royals (58-45), 2-1 | Cleveland Stadium (31-22) | 50-54 | Won 2 |
| » W: Jim Kern (8-5) L: Steve Mingori (1-3) | Sixth | 15 out |
| Wednesday, August 2 |
| » Defeated Royals (58-46), 5-2 | Cleveland Stadium (32-22) | 51-54 | Won 3 |
| » W: Paul Reuschel (4-0) L: Dennis Leonard (12-13) | Sixth | 15 out |
| Friday, August 4 |
| » Lost to Rangers (50-56), 8-0 | Arlington Stadium (0-3) | 51-55 | |
| » W: Fergie Jenkins (10-7) L: Rick Wise (8-14) | Sixth | 15½ out |
| Saturday, August 5 |
| » Lost to Rangers (51-56), 4-3 | Arlington Stadium (0-4) | 51-56 | Lost 2 |
| » W: Steve Comer (4-3) L: Jim Kern (8-6) | Sixth | 16½ out |
| Sunday, August 6 |
| » Lost to Rangers (52-56), 3-2 | Arlington Stadium (0-5) | 51-57 | Lost 3 |
| » W: Jon Matlack (9-9) L: Rick Waits (7-12) | Fifth | 17½ out |
| Tuesday, August 8 |
| » Lost to Red Sox (70-40), 9-7 | Fenway Park (2-3) | 51-58 | Lost 4 |
| » W: Bob Stanley (7-1) L: Dave Freisleben (1-6) | Sixth | 18½ out |
| Wednesday, August 9 |
| » Defeated Red Sox (70-41), 5-1 | Fenway Park (3-3) | 52-58 | |
| » W: Rick Wise (9-14) L: Bill Lee (10-8) S: Jim Kern (9) | Sixth | 17½ out |
| Thursday, August 10 |
| » Lost to Red Sox (71-41), 6-5 | Fenway Park (3-4) | 52-59 | |
| » W: Bob Stanley (8-1) L: Dan Spillner (3-1) | Sixth | 18½ out |
| Friday, August 11 |
| » Lost to Rangers (54-57), 8-2 | Cleveland Stadium (32-23) | 52-60 | Lost 2 |
| » W: Jon Matlack (10-9) L: Rick Waits (7-13) | Sixth | 18½ out |
| Saturday, August 12 |
| » Lost to Rangers (55-57), 6-1 | Cleveland Stadium (32-24) | 52-61 | Lost 3 |
| » W: Doyle Alexander (7-8) L: David Clyde (5-7) | Fifth | 20 out |
| Sunday, August 13 |
| » Lost to Rangers (56-57), 3-2 | Cleveland Stadium (32-25) | 52-62 | Lost 4 |
| » W: Doc Medich (6-6) L: Dave Freisleben (1-7) S: Reggie Cleveland (10) | Sixth | 21½ out |
| » Lost to Rangers (57-57), 6-5 | Cleveland Stadium (32-26) | 52-63 | Lost 5 |
| » W: Steve Comer (5-3) L: Rick Wise (9-15) S: Len Barker (2) | Sixth | 21½ out |
| Monday, August 14 |
| » Defeated Twins (51-66), 4-3 | Cleveland Stadium (33-26) | 53-63 | |
| » W: Mike Paxton (9-6) L: Jeff Holly (0-1) S: Jim Kern (10) | Sixth | 20½ out |
| Tuesday, August 15 |
| » Lost to Twins (52-66), 9-8 | Cleveland Stadium (33-27) | 53-64 | |
| » W: Mike Marshall (6-11) L: Sid Monge (3-2) S: Gary Serum (1) | Fifth | 20½ out |
| Wednesday, August 16 |
| » Lost to Tigers (65-52), 2-0 | Tiger Stadium (0-3) | 53-65 | Lost 2 |
| » W: Jack Billingham (13-5) L: David Clyde (5-8) | Sixth | 21½ out |
| Thursday, August 17 |
| » Lost to Tigers (66-52), 9-5 | Tiger Stadium (0-4) | 53-66 | Lost 3 |
| » W: Jack Morris (3-4) L: Don Hood (5-5) | Sixth | 22½ out |
| Friday, August 18 |
| » Lost to White Sox (50-70), 7-1 | Cleveland Stadium (33-28) | 53-67 | Lost 4 |
| » W: Mike Proly (3-2) L: Rick Wise (9-16) | Sixth | 23½ out |
| Saturday, August 19 |
| » Lost to White Sox (51-70), 2-1 | Cleveland Stadium (33-29) | 53-68 | Lost 5 |
| » W: Francisco Barrios (8-10) L: Mike Paxton (9-7) | Sixth | 23½ out |
| Sunday, August 20 |
| » Defeated White Sox (51-71), 10-1 | Cleveland Stadium (34-29) | 54-68 | |
| » W: Rick Waits (8-13) L: Steve Stone (9-10) | Fifth | 23½ out |
| Tuesday, August 22 |
| » Lost to Brewers (70-53), 3-2 | County Stadium (2-3) | 54-69 | |
| » W: Bill Castro (4-4) L: Jim Kern (8-7) | Sixth | 24 out |
| » Lost to Brewers (71-53), 5-4 | County Stadium (2-4) | 54-70 | Lost 2 |
| » W: Willie Mueller (1-0) L: Jim Kern (8-8) | Sixth | 24 out |
| Wednesday, August 23 |
| » Lost to Brewers (72-53), 9-4 | County Stadium (2-5) | 54-71 | Lost 3 |
| » W: Andy Replogle (6-2) L: Sid Monge (3-3) | Sixth | 24 out |
| Thursday, August 24 |
| » Defeated Brewers (72-54), 9-8 | County Stadium (3-5) | 55-71 | |
| » W: Dan Spillner (4-1) L: Bob McClure (2-4) S: Sid Monge (6) | Sixth | 23½ out |
| Friday, August 25 |
| » Defeated White Sox (53-73), 2-1 | Comiskey Park I (1-2) | 56-71 | Won 2 |
| » W: Rick Waits (9-13) L: Francisco Barrios (8-11) S: Jim Kern (11) | Sixth | 23½ out |
| Saturday, August 26 |
| » Lost to White Sox (54-73), 8-7 | Comiskey Park I (1-3) | 56-72 | |
| » W: Steve Stone (10-10) L: David Clyde (5-9) S: Jim Willoughby (13) | Sixth | 24½ out |
| Sunday, August 27 |
| » Lost to White Sox (55-73), 6-0 | Comiskey Park I (1-4) | 56-73 | Lost 2 |
| » W: Ross Baumgarten (2-1) L: Paul Reuschel (4-1) | Sixth | 25½ out |
| Tuesday, August 29 |
| » Lost to Brewers (75-56), 6-0 | Cleveland Stadium (34-30) | 56-74 | Lost 3 |
| » W: Andy Replogle (7-2) L: Rick Wise (9-17) | Sixth | 27 out |
| Wednesday, August 30 |
| Future Indian Cliff Lee is born in Benton, AR. |
| Thursday, August 31 |
| » Lost to Brewers (76-56), 1-0 | Cleveland Stadium (34-31) | 56-75 | Lost 4 |
| » W: Mike Caldwell (17-8) L: Mike Paxton (9-8) | Sixth | 27 out |
| » Defeated Brewers (76-57), 12-6 | Cleveland Stadium (35-31) | 57-75 | |
| » W: Rick Waits (10-13) L: Bill Travers (9-8) | Sixth | 27 out |
| Future Indian Tim Drew is born in Valdosta, GA. |
| Friday, September 1 |
| » Defeated Twins (58-76), 4-1 | Metropolitan Stadium (1-1) | 58-75 | Won 2 |
| » W: David Clyde (6-9) L: Roger Erickson (13-9) S: Dan Spillner (3) | Sixth | 26 out |
| Saturday, September 2 |
| » Lost to Twins (59-76), 2-1 | Metropolitan Stadium (1-2) | 58-76 | |
| » W: Dave Goltz (11-9) L: Paul Reuschel (4-2) S: Mike Marshall (18) | Sixth | 26 out |
| Sunday, September 3 |
| » Lost to Twins (60-76), 12-3 | Metropolitan Stadium (1-3) | 58-77 | Lost 2 |
| » W: Gary Serum (8-6) L: Rick Wise (9-18) | Sixth | 27½ out |
| » Lost to Twins (61-76), 4-3 | Metropolitan Stadium (1-4) | 58-78 | Lost 3 |
| » W: Mike Marshall (8-11) L: Jim Kern (8-9) | Sixth | 27½ out |
| Monday, September 4 |
| » Defeated Blue Jays (55-84), 5-4 | Exhibition Stadium (5-2) | 59-78 | |
| » W: Mike Paxton (10-8) L: Balor Moore (6-6) | Sixth | 26½ out |
| Tuesday, September 5 |
| » Defeated Blue Jays (55-85), 6-2 | Exhibition Stadium (6-2) | 60-78 | Won 2 |
| » W: Rick Waits (11-13) L: Don Kirkwood (3-3) | Sixth | 25½ out |
| Friday, September 8 |
| » Lost to Tigers (76-64), 6-3 | Tiger Stadium (0-5) | 60-79 | |
| » W: Jim Slaton (15-10) L: David Clyde (6-10) S: John Hiller (12) | Sixth | 25½ out |
| Saturday, September 9 |
| » Lost to Tigers (77-64), 5-2 | Tiger Stadium (0-6) | 60-80 | Lost 2 |
| » W: Dave Rozema (7-10) L: Mike Paxton (10-9) | Sixth | 25½ out |
| Sunday, September 10 |
| » Defeated Tigers (77-65), 7-4 | Tiger Stadium (1-6) | 61-80 | |
| » W: Jim Kern (9-9) L: Milt Wilcox (12-10) | Fifth | 24½ out |
| Monday, September 11 |
| » Defeated Blue Jays (56-89), 6-4 | Cleveland Stadium (36-31) | 62-80 | Won 2 |
| » W: Rick Waits (12-13) L: Jesse Jefferson (7-13) | Sixth | 25 out |
| » Lost to Blue Jays (57-89), 7-1 | Cleveland Stadium (36-32) | 62-81 | |
| » W: Don Kirkwood (4-3) L: Rick Wise (9-19) | Sixth | 25 out |
| Wednesday, September 13 |
| » Defeated Red Sox (87-58), 2-1 | Cleveland Stadium (37-32) | 63-81 | |
| » W: David Clyde (7-10) L: Dennis Eckersley (16-8) S: Jim Kern (12) | Sixth | 24 out |
| Thursday, September 14 |
| » Defeated Red Sox (87-59), 4-3 | Cleveland Stadium (38-32) | 64-81 | Won 2 |
| » W: Mike Paxton (11-9) L: Jim Wright (8-4) S: Jim Kern (13) | Sixth | 24 out |
| Friday, September 15 |
| » Lost to Tigers (79-67), 1-0 | Cleveland Stadium (38-33) | 64-82 | |
| » W: Dave Rozema (8-10) L: Paul Reuschel (4-3) | Sixth | 25 out |
| Saturday, September 16 |
| » Lost to Tigers (80-67), 10-4 | Cleveland Stadium (38-34) | 64-83 | Lost 2 |
| » W: Milt Wilcox (13-10) L: Rick Waits (12-14) | Sixth | 26 out |
| Sunday, September 17 |
| » Defeated Tigers (80-68), 2-1 | Cleveland Stadium (39-34) | 65-83 | |
| » W: Jim Kern (10-9) L: Kip Young (6-6) | Sixth | 25 out |
| Monday, September 18 |
| » Lost to Orioles (85-65), 10-3 | Cleveland Stadium (39-35) | 65-84 | |
| » W: Scott McGregor (15-13) L: David Clyde (7-11) | Sixth | 26 out |
| Tuesday, September 19 |
| » Defeated Orioles (85-66), 2-1 | Cleveland Stadium (40-35) | 66-84 | |
| » W: Mike Paxton (12-9) L: Don Stanhouse (6-7) | Sixth | 25 out |
| Friday, September 22 |
| » Defeated Yankees (93-61), 8-7 | Cleveland Stadium (41-35) | 67-84 | Won 2 |
| » W: Sid Monge (4-3) L: Rich Gossage (10-11) | Sixth | 24½ out |
| Saturday, September 23 |
| » Defeated Yankees (93-62), 10-1 | Cleveland Stadium (42-35) | 68-84 | Won 3 |
| » W: David Clyde (8-11) L: Jim Beattie (5-9) | Sixth | 23½ out |
| Sunday, September 24 |
| » Lost to Yankees (94-62), 4-0 | Cleveland Stadium (42-36) | 68-85 | |
| » W: Ron Guidry (23-3) L: Mike Paxton (12-10) | Sixth | 24½ out |
| Tuesday, September 26 |
| » Lost to Orioles (87-69), 3-1 | Memorial Stadium (2-3) | 68-86 | Lost 2 |
| » W: Mike Flanagan (19-14) L: Paul Reuschel (4-4) S: Don Stanhouse (23) | Sixth | 25½ out |
| Wednesday, September 27 |
| » Lost to Orioles (88-69), 3-1 | Memorial Stadium (2-4) | 68-87 | Lost 3 |
| » W: Dennis Martinez (15-11) L: Rick Waits (12-15) | Sixth | 26½ out |
| Thursday, September 28 |
| » Lost to Orioles (89-69), 3-2 | Memorial Stadium (2-5) | 68-88 | Lost 4 |
| » W: Jim Palmer (21-12) L: Don Hood (5-6) S: Don Stanhouse (24) | Sixth | 27½ out |
| Friday, September 29 |
| » Lost to Yankees (98-62), 3-1 | Yankee Stadium (1-5) | 68-89 | Lost 5 |
| » W: Jim Beattie (6-9) L: Jim Kern (10-10) S: Rich Gossage (26) | Sixth | 28½ out |
| Saturday, September 30 |
| » Lost to Yankees (99-62), 7-0 | Yankee Stadium (1-6) | 68-90 | Lost 6 |
| » W: Ed Figueroa (20-9) L: Mike Paxton (12-11) | Sixth | 29½ out |
| Sunday, October 1 |
| » Defeated Yankees (99-63), 9-2 | Yankee Stadium (2-6) | 69-90 | |
| » W: Rick Waits (13-15) L: Catfish Hunter (12-6) | Fifth | 28½ out |
| Friday, December 8 |
| Former Indian Nick Cullop dies in Westerville, OH at the age of 79. |
| Monday, December 11 |
| Former Indian Paul O'Dea dies in Cleveland, OH at the age of 59. |
| Saturday, December 23 |
| Future Indian Victor Martinez is born in Ciudad Bolivar, Venezuela. |
Game information provided by Retrosheet (www.retrosheet.org) |