| Sunday, February 19 |
| Former Cardinal Phil Paine dies in Lebanon, PA at the age of 48. |
| Tuesday, March 7 |
| Former Cardinal Steve Bilko dies in Wilkes-Barre, PA at the age of 50. |
| Sunday, March 12 |
| Former Cardinal Gene Moore dies in Jackson, MS at the age of 69. |
| Wednesday, April 5 |
| » Major-league debuts: Hosken Powell (Twins) |
| Friday, April 7 |
| » Defeated Phillies (0-1), 5-1 | Veteran's Stadium (1-0) | 1-0 | |
| » W: Bob Forsch (1-0) L: Steve Carlton (0-1) | First | -- |
| Saturday, April 8 |
| » Lost to Phillies (1-1), 7-0 | Veteran's Stadium (1-1) | 1-1 | |
| » W: Larry Christenson (1-0) L: Eric Rasmussen (0-1) | Second | 1 out |
| Sunday, April 9 |
| » Lost to Phillies (2-1), 12-3 | Veteran's Stadium (1-2) | 1-2 | Lost 2 |
| » W: Randy Lerch (1-0) L: John Urrea (0-1) | Third | 1½ out |
| Monday, April 10 |
| » Defeated Pirates (2-2), 11-2 | Busch Stadium II (1-0) | 2-2 | |
| » W: John Denny (1-0) L: Jim Rooker (0-1) | Third | 1½ out |
| » Major-league debuts: Don Robinson (Pirates) |
| Wednesday, April 12 |
| » Defeated Pirates (2-3), 5-1 | Busch Stadium II (2-0) | 3-2 | Won 2 |
| » W: Bob Forsch (2-0) L: John Candelaria (1-1) | First | -- |
| Thursday, April 13 |
| » Defeated Pirates (2-4), 6-5 | Busch Stadium II (3-0) | 4-2 | Won 3 |
| » W: Eric Rasmussen (1-1) L: Bert Blyleven (0-1) | First | -- |
| Friday, April 14 |
| » Lost to Phillies (3-2), 4-3 | Busch Stadium II (3-1) | 4-3 | |
| » W: Steve Carlton (1-1) L: Pete Vuckovich (0-1) S: Tug McGraw (1) | Third | ½ out |
| Saturday, April 15 |
| » Lost to Phillies (4-2), 3-2 | Busch Stadium II (3-2) | 4-4 | Lost 2 |
| » W: Tug McGraw (1-0) L: Pete Vuckovich (0-2) | Third | 1 out |
| Sunday, April 16 |
| » Defeated Phillies (4-3), 5-0 | Busch Stadium II (4-2) | 5-4 | |
| » W: Bob Forsch (3-0) L: Randy Lerch (1-1) | Second | 1 out |
| Monday, April 17 |
| » Lost to Mets (6-5), 6-2 | Busch Stadium II (4-3) | 5-5 | |
| » W: Nino Espinosa (1-1) L: Pete Falcone (0-1) S: Skip Lockwood (2) | Fifth | 1 out |
| Tuesday, April 18 |
| » Lost to Mets (7-5), 3-2 | Busch Stadium II (4-4) | 5-6 | Lost 2 |
| » W: Mike Bruhert (1-1) L: Eric Rasmussen (1-2) S: Skip Lockwood (3) | Fourth | 1½ out |
| Wednesday, April 19 |
| » Lost to Mets (8-5), 2-0 | Busch Stadium II (4-5) | 5-7 | Lost 3 |
| » W: Pat Zachry (2-0) L: Mark Littell (0-1) | Fifth | 2 out |
| Saturday, April 22 |
| » Lost to Pirates (4-7), 8-7 | Three Rivers Stadium (0-1) | 5-8 | Lost 4 |
| » W: Kent Tekulve (1-0) L: John Urrea (0-2) | Fifth | 3 out |
| Sunday, April 23 |
| » Lost to Pirates (5-7), 14-7 | Three Rivers Stadium (0-2) | 5-9 | Lost 5 |
| » W: Bruce Kison (1-1) L: Bob Forsch (3-1) | Sixth | 4 out |
| » Lost to Pirates (6-7), 5-4 | Three Rivers Stadium (0-3) | 5-10 | Lost 6 |
| » Manager: Ken Boyer |
| » W: Jim Bibby (2-1) L: Pete Vuckovich (0-3) S: Don Robinson (1) | Sixth | 4 out |
| Monday, April 24 |
| » Lost to Expos (9-5), 5-3 | Stade Olympique (0-1) | 5-11 | Lost 7 |
| » Manager: Vern Rapp |
| » W: Rudy May (1-1) L: Mark Littell (0-2) S: Stan Bahnsen (3) | Sixth | 5 out |
| Tuesday, April 25 |
| » Defeated Expos (9-6), 7-2 | Stade Olympique (1-1) | 6-11 | |
| » W: John Urrea (1-2) L: Hal Dues (0-1) | Sixth | 4 out |
| Wednesday, April 26 |
| » Defeated Expos (9-7), 12-2 | Stade Olympique (2-1) | 7-11 | Won 2 |
| » Manager: Jack Krol |
| » W: John Denny (2-0) L: Wayne Twitchell (1-2) | Fifth | 3 out |
| Friday, April 28 |
| » Lost to Dodgers (13-5), 7-1 | Busch Stadium II (4-6) | 7-12 | |
| » W: Rick Rhoden (3-0) L: Bob Forsch (3-2) | Sixth | 4 out |
| Saturday, April 29 |
| » Defeated Dodgers (13-6), 1-0 | Busch Stadium II (5-6) | 8-12 | |
| » Manager: Ken Boyer |
| » W: Eric Rasmussen (2-2) L: Burt Hooton (1-3) | Fifth | 3 out |
| Sunday, April 30 |
| » Defeated Dodgers (13-7), 4-0 | Busch Stadium II (6-6) | 9-12 | Won 2 |
| » W: John Urrea (2-2) L: Don Sutton (2-2) S: Pete Vuckovich (1) | Sixth | 3 out |
| Monday, May 1 |
| » Lost to Giants (11-10), 2-1 | Busch Stadium II (6-7) | 9-13 | |
| » W: Vida Blue (3-1) L: John Denny (2-1) S: Randy Moffitt (2) | Fifth | 4 out |
| Tuesday, May 2 |
| » Defeated Giants (11-11), 9-0 | Busch Stadium II (7-7) | 10-13 | |
| » W: Bob Forsch (4-2) L: John Montefusco (1-2) | Fifth | 3½ out |
| Wednesday, May 3 |
| » Lost to Giants (12-11), 4-0 | Busch Stadium II (7-8) | 10-14 | |
| » W: Jim Barr (2-3) L: Eric Rasmussen (2-3) | Fifth | 4 out |
| Friday, May 5 |
| » Lost to Padres (10-13), 2-1 | Busch Stadium II (7-9) | 10-15 | Lost 2 |
| » W: Randy Jones (2-2) L: John Urrea (2-3) S: Rollie Fingers (6) | Sixth | 5 out |
| Saturday, May 6 |
| » Defeated Padres (10-14), 1-0 | Busch Stadium II (8-9) | 11-15 | |
| » W: John Denny (3-1) L: Gaylord Perry (2-1) | Fourth | 4½ out |
| Sunday, May 7 |
| » Defeated Padres (10-15), 8-4 | Busch Stadium II (9-9) | 12-15 | Won 2 |
| » W: Bob Forsch (5-2) L: Dave Freisleben (0-3) | Fifth | 4½ out |
| Tuesday, May 9 |
| » Lost to Dodgers (17-10), 3-1 | Dodger Stadium (0-1) | 12-16 | |
| » W: Doug Rau (5-0) L: Eric Rasmussen (2-4) S: Terry Forster (4) | Fourth | 4½ out |
| Wednesday, May 10 |
| » Defeated Dodgers (17-11), 6-5 | Dodger Stadium (1-1) | 13-16 | |
| » W: Mark Littell (1-2) L: Rick Rhoden (4-1) | Fifth | 4½ out |
| Thursday, May 11 |
| » Defeated Dodgers (17-12), 2-0 | Dodger Stadium (2-1) | 14-16 | Won 2 |
| » W: Bob Forsch (6-2) L: Burt Hooton (2-4) | Fourth | 4½ out |
| Friday, May 12 |
| » Lost to Giants (17-12), 9-3 | Candlestick Park (0-1) | 14-17 | |
| » W: Vida Blue (5-1) L: John Urrea (2-4) | Fifth | 4½ out |
| Saturday, May 13 |
| » Lost to Giants (18-12), 7-6 | Candlestick Park (0-2) | 14-18 | Lost 2 |
| » W: John Montefusco (2-2) L: Mark Littell (1-3) S: Gary Lavelle (5) | Fifth | 4½ out |
| Sunday, May 14 |
| » Lost to Giants (19-12), 5-4 | Candlestick Park (0-3) | 14-19 | Lost 3 |
| » W: Gary Lavelle (3-2) L: Mark Littell (1-4) | Fifth | 6 out |
| » Lost to Giants (20-12), 4-3 | Candlestick Park (0-4) | 14-20 | Lost 4 |
| » W: Charlie Williams (1-0) L: Mark Littell (1-5) | Fifth | 6 out |
| Monday, May 15 |
| » Lost to Padres (14-18), 4-3 | San Diego/Jack Murphy Stadium (0-1) | 14-21 | Lost 5 |
| » W: Mark Lee (2-1) L: Pete Vuckovich (0-4) | Sixth | 6 out |
| Tuesday, May 16 |
| » Lost to Padres (15-18), 7-5 | San Diego/Jack Murphy Stadium (0-2) | 14-22 | Lost 6 |
| » W: Bob Owchinko (3-2) L: John Urrea (2-5) S: John D'Acquisto (1) | Sixth | 6 out |
| Wednesday, May 17 |
| » Lost to Padres (16-18), 5-2 | San Diego/Jack Murphy Stadium (0-3) | 14-23 | Lost 7 |
| » W: Bob Shirley (1-4) L: Eric Rasmussen (2-5) S: Rollie Fingers (9) | Sixth | 6 out |
| Friday, May 19 |
| » Lost to Cubs (17-17), 6-2 | Wrigley Field (0-1) | 14-24 | Lost 8 |
| » W: Dave Roberts (1-0) L: John Denny (3-2) | Sixth | 6½ out |
| Saturday, May 20 |
| » Lost to Cubs (18-17), 10-2 | Wrigley Field (0-2) | 14-25 | Lost 9 |
| » W: Woodie Fryman (2-4) L: Pete Falcone (0-2) S: Donnie Moore (4) | Sixth | 7½ out |
| Sunday, May 21 |
| » Lost to Cubs (19-17), 3-2 | Wrigley Field (0-3) | 14-26 | Lost 10 |
| » W: Rick Reuschel (4-3) L: Mark Littell (1-6) S: Bruce Sutter (5) | Fifth | 7½ out |
| Tuesday, May 23 |
| » Lost to Expos (20-19), 4-1 | Busch Stadium II (9-10) | 14-27 | Lost 11 |
| » W: Rudy May (3-5) L: Bob Forsch (6-3) S: Mike Garman (1) | Sixth | 8 out |
| Wednesday, May 24 |
| » Defeated Expos (20-20), 2-0 | Busch Stadium II (10-10) | 15-27 | |
| » W: John Denny (4-2) L: Hal Dues (0-2) | Sixth | 7½ out |
| Thursday, May 25 |
| » Lost to Expos (21-20), 11-2 | Busch Stadium II (10-11) | 15-28 | |
| » W: Ross Grimsley (7-2) L: John Urrea (2-6) | Sixth | 8½ out |
| » Major-league debuts: George Frazier (Cardinals) |
| Friday, May 26 |
| » Lost to Cubs (22-17), 6-0 | Busch Stadium II (10-12) | 15-29 | Lost 2 |
| » W: Dave Roberts (2-0) L: Pete Falcone (0-3) | Sixth | 9½ out |
| Saturday, May 27 |
| » Lost to Cubs (23-17), 3-2 | Busch Stadium II (10-13) | 15-30 | Lost 3 |
| » W: Willie Hernandez (4-1) L: Buddy Schultz (0-1) | Sixth | 10½ out |
| Sunday, May 28 |
| » Lost to Cubs (24-17), 2-0 | Busch Stadium II (10-14) | 15-31 | Lost 4 |
| » W: Ray Burris (3-3) L: John Denny (4-3) | Sixth | 11½ out |
| Monday, May 29 |
| » Lost to Mets (23-24), 7-2 | Shea Stadium (0-1) | 15-32 | Lost 5 |
| » W: Pat Zachry (5-1) L: John Urrea (2-7) | Sixth | 11 out |
| » Defeated Mets (23-25), 6-2 | Shea Stadium (1-1) | 16-32 | |
| » W: Pete Vuckovich (1-4) L: Craig Swan (1-3) | Sixth | 11 out |
| Tuesday, May 30 |
| » Defeated Mets (23-26), 8-2 | Shea Stadium (2-1) | 17-32 | Won 2 |
| » W: Silvio Martinez (1-0) L: Jerry Koosman (2-6) | Sixth | 10 out |
| Wednesday, May 31 |
| » Defeated Mets (23-27), 5-4 | Shea Stadium (3-1) | 18-32 | Won 3 |
| » W: Bob Forsch (7-3) L: Mike Bruhert (1-4) S: Buddy Schultz (1) | Sixth | 9 out |
| Friday, June 2 |
| » Lost to Astros (21-25), 2-1 | Astrodome (0-1) | 18-33 | |
| » W: Joe Sambito (3-3) L: John Denny (4-4) | Sixth | 10 out |
| Former Cardinal Bob McGraw dies in Boise, ID at the age of 84. |
| Saturday, June 3 |
| » Lost to Astros (22-25), 5-2 | Astrodome (0-2) | 18-34 | Lost 2 |
| » W: Floyd Bannister (2-3) L: Pete Falcone (0-4) S: Ken Forsch (2) | Sixth | 10½ out |
| » Defeated Astros (22-26), 2-1 | Astrodome (1-2) | 19-34 | |
| » W: Pete Vuckovich (2-4) L: Tom Dixon (2-2) | Sixth | 10½ out |
| Sunday, June 4 |
| » Defeated Astros (22-27), 4-2 | Astrodome (2-2) | 20-34 | Won 2 |
| » W: Silvio Martinez (2-0) L: J.R. Richard (4-6) S: Buddy Schultz (2) | Sixth | 10½ out |
| Monday, June 5 |
| » Lost to Reds (33-20), 2-1 | Busch Stadium II (10-15) | 20-35 | |
| » W: Tom Seaver (6-4) L: Bob Forsch (7-4) | Sixth | 11½ out |
| Tuesday, June 6 |
| » Defeated Reds (33-21), 4-1 | Busch Stadium II (11-15) | 21-35 | |
| » W: John Denny (5-4) L: Tom Hume (2-6) | Sixth | 11½ out |
| Wednesday, June 7 |
| » Lost to Braves (20-31), 6-0 | Busch Stadium II (11-16) | 21-36 | |
| » W: Phil Niekro (6-6) L: Pete Falcone (0-5) | Sixth | 11½ out |
| Thursday, June 8 |
| » Defeated Braves (20-32), 2-0 | Busch Stadium II (12-16) | 22-36 | |
| » W: Pete Vuckovich (3-4) L: Preston Hanna (4-1) S: Mark Littell (1) | Sixth | 11½ out |
| Friday, June 9 |
| » Lost to Astros (23-29), 11-7 | Busch Stadium II (12-17) | 22-37 | |
| » W: J.R. Richard (5-6) L: George Frazier (0-1) S: Ken Forsch (3) | Sixth | 12½ out |
| Saturday, June 10 |
| » Lost to Astros (24-29), 12-5 | Busch Stadium II (12-18) | 22-38 | Lost 2 |
| » W: Mark Lemongello (6-6) L: Bob Forsch (7-5) | Sixth | 12½ out |
| Sunday, June 11 |
| » Defeated Astros (24-30), 5-3 | Busch Stadium II (13-18) | 23-38 | |
| » W: John Denny (6-4) L: Joaquin Andujar (3-4) | Sixth | 12½ out |
| Monday, June 12 |
| » Lost to Braves (22-34), 2-1 | Atlanta-Fulton County Stadium (0-1) | 23-39 | |
| » W: Mickey Mahler (1-2) L: Pete Vuckovich (3-5) | Sixth | 13½ out |
| Tuesday, June 13 |
| » Lost to Braves (23-34), 12-1 | Atlanta-Fulton County Stadium (0-2) | 23-40 | Lost 2 |
| » W: Preston Hanna (5-1) L: Silvio Martinez (2-1) | Sixth | 13½ out |
| Wednesday, June 14 |
| » Lost to Braves (24-34), 7-1 | Atlanta-Fulton County Stadium (0-3) | 23-41 | Lost 3 |
| » W: Adrian Devine (3-3) L: Bob Forsch (7-6) | Sixth | 13½ out |
| Friday, June 16 |
| » Lost to Reds (38-25), 4-0 | Riverfront Stadium (0-1) | 23-42 | Lost 4 |
| » W: Tom Seaver (8-4) L: John Denny (6-5) | Sixth | 14½ out |
| Saturday, June 17 |
| » Lost to Reds (39-25), 6-5 | Riverfront Stadium (0-2) | 23-43 | Lost 5 |
| » W: Pedro Borbon (3-1) L: Buddy Schultz (0-2) | Sixth | 14½ out |
| Sunday, June 18 |
| » Lost to Reds (40-25), 4-2 | Riverfront Stadium (0-3) | 23-44 | Lost 6 |
| » W: Fred Norman (8-3) L: Silvio Martinez (2-2) S: Manny Sarmiento (3) | Sixth | 14½ out |
| Tuesday, June 20 |
| » Defeated Phillies (31-29), 4-2 | Veteran's Stadium (2-2) | 24-44 | |
| » W: Bob Forsch (8-6) L: Larry Christenson (4-6) S: Mark Littell (2) | Sixth | 14 out |
| Thursday, June 22 |
| » Lost to Phillies (32-29), 2-1 | Veteran's Stadium (2-3) | 24-45 | |
| » W: Steve Carlton (8-6) L: John Denny (6-6) | Sixth | 14 out |
| Friday, June 23 |
| » Defeated Expos (35-34), 8-4 | Busch Stadium II (14-18) | 25-45 | |
| » W: Pete Vuckovich (4-5) L: Rudy May (6-7) S: Mark Littell (3) | Sixth | 12½ out |
| Saturday, June 24 |
| » Lost to Expos (36-34), 2-0 | Busch Stadium II (14-19) | 25-46 | |
| » W: Woodie Fryman (3-5) L: Silvio Martinez (2-3) S: Mike Garman (5) | Sixth | 13½ out |
| Sunday, June 25 |
| » Defeated Expos (36-35), 7-5 | Busch Stadium II (15-19) | 26-46 | |
| » W: Buddy Schultz (1-2) L: Rudy May (6-8) | Sixth | 13½ out |
| Monday, June 26 |
| » Lost to Pirates (34-34), 11-8 | Three Rivers Stadium (0-4) | 26-47 | |
| » W: Ed Whitson (2-2) L: John Urrea (2-8) S: Kent Tekulve (8) | Sixth | 13½ out |
| Tuesday, June 27 |
| » Defeated Pirates (34-35), 2-0 | Three Rivers Stadium (1-4) | 27-47 | |
| » W: Pete Vuckovich (5-5) L: John Candelaria (7-7) S: Buddy Schultz (3) | Sixth | 13 out |
| » Defeated Pirates (34-36), 6-1 | Three Rivers Stadium (2-4) | 28-47 | Won 2 |
| » W: Pete Falcone (1-5) L: Jerry Reuss (0-1) | Sixth | 13 out |
| Wednesday, June 28 |
| » Defeated Pirates (34-37), 7-5 | Three Rivers Stadium (3-4) | 29-47 | Won 3 |
| » W: Roy Thomas (1-0) L: Kent Tekulve (4-5) | Sixth | 13 out |
| Former Cardinal Johnny Schulte dies in St.Louis, MO at the age of 82. |
| Friday, June 30 |
| » Defeated Expos (37-38), 2-1 | Stade Olympique (3-1) | 30-47 | Won 4 |
| » W: Bob Forsch (9-6) L: Ross Grimsley (11-5) S: Roy Thomas (1) | Sixth | 13 out |
| Saturday, July 1 |
| » Lost to Expos (38-38), 3-2 | Stade Olympique (3-2) | 30-48 | |
| » W: Steve Rogers (10-7) L: Mark Littell (1-7) | Sixth | 14 out |
| Sunday, July 2 |
| » Defeated Expos (38-39), 5-4 | Stade Olympique (4-2) | 31-48 | |
| » W: Pete Vuckovich (6-5) L: Woodie Fryman (3-6) S: Buddy Schultz (4) | Sixth | 13½ out |
| » Defeated Expos (38-40), 4-2 | Stade Olympique (5-2) | 32-48 | Won 2 |
| » W: John Urrea (3-8) L: Rudy May (6-9) S: Roy Thomas (2) | Sixth | 13½ out |
| Monday, July 3 |
| » Lost to Cubs (39-37), 6-2 | Busch Stadium II (15-20) | 32-49 | |
| » W: Dave Roberts (4-3) L: Pete Falcone (1-6) S: Bruce Sutter (10) | Sixth | 14 out |
| Tuesday, July 4 |
| » Lost to Cubs (40-37), 7-5 | Busch Stadium II (15-21) | 32-50 | Lost 2 |
| » W: Dave Geisel (1-0) L: George Frazier (0-2) S: Bruce Sutter (11) | Sixth | 14½ out |
| Wednesday, July 5 |
| » Lost to Cubs (41-37), 5-1 | Busch Stadium II (15-22) | 32-51 | Lost 3 |
| » W: Mike Krukow (2-0) L: Bob Forsch (9-7) S: Bruce Sutter (12) | Sixth | 15½ out |
| Thursday, July 6 |
| » Defeated Pirates (38-40), 3-2 | Busch Stadium II (16-22) | 33-51 | |
| » W: John Denny (7-6) L: Jim Rooker (3-6) | Sixth | 15½ out |
| Friday, July 7 |
| » Lost to Pirates (39-40), 2-1 | Busch Stadium II (16-23) | 33-52 | |
| » W: John Candelaria (8-8) L: Pete Vuckovich (6-6) S: Kent Tekulve (12) | Sixth | 15½ out |
| Saturday, July 8 |
| » Defeated Pirates (39-41), 4-0 | Busch Stadium II (17-23) | 34-52 | |
| » W: Silvio Martinez (3-3) L: Don Robinson (5-3) | Sixth | 15 out |
| » Major-league debuts: Steve Nicosia (Pirates) |
| Sunday, July 9 |
| » Lost to Pirates (40-41), 6-1 | Busch Stadium II (17-24) | 34-53 | |
| » W: Bert Blyleven (9-5) L: Bob Forsch (9-8) S: Kent Tekulve (13) | Sixth | 16 out |
| Thursday, July 13 |
| » Defeated Dodgers (50-37), 6-1 | Busch Stadium II (18-24) | 35-53 | |
| » W: John Denny (8-6) L: Tommy John (10-7) | Sixth | 15½ out |
| Friday, July 14 |
| » Defeated Dodgers (50-38), 4-1 | Busch Stadium II (19-24) | 36-53 | Won 2 |
| » W: Pete Vuckovich (7-6) L: Don Sutton (9-8) | Sixth | 14½ out |
| Saturday, July 15 |
| » Lost to Dodgers (51-38), 2-1 | Busch Stadium II (19-25) | 36-54 | |
| » W: Doug Rau (10-4) L: Bob Forsch (9-9) S: Terry Forster (11) | Sixth | 14½ out |
| Sunday, July 16 |
| » Defeated Giants (54-36), 9-4 | Busch Stadium II (20-25) | 37-54 | |
| » W: Silvio Martinez (4-3) L: Jim Barr (4-7) S: Buddy Schultz (5) | Sixth | 15 out |
| » Lost to Giants (55-36), 6-0 | Busch Stadium II (20-26) | 37-55 | |
| » W: Ed Halicki (5-3) L: John Urrea (3-9) | Sixth | 15 out |
| Monday, July 17 |
| » Lost to Giants (56-36), 9-7 | Busch Stadium II (20-27) | 37-56 | Lost 2 |
| » W: Gary Lavelle (8-7) L: Buddy Schultz (1-3) | Sixth | 15 out |
| Tuesday, July 18 |
| » Lost to Padres (45-49), 3-2 | Busch Stadium II (20-28) | 37-57 | Lost 3 |
| » W: Eric Rasmussen (9-7) L: Pete Vuckovich (7-7) | Sixth | 15 out |
| Wednesday, July 19 |
| » Lost to Padres (46-49), 5-3 | Busch Stadium II (20-29) | 37-58 | Lost 4 |
| » W: Randy Jones (7-8) L: Roy Thomas (1-1) S: Bob Shirley (1) | Sixth | 15 out |
| Thursday, July 20 |
| » Defeated Padres (46-50), 3-2 | Busch Stadium II (21-29) | 38-58 | |
| » W: Buddy Schultz (2-3) L: Rollie Fingers (4-11) S: Mark Littell (4) | Sixth | 15 out |
| Friday, July 21 |
| » Lost to Dodgers (55-41), 7-5 | Dodger Stadium (2-2) | 38-59 | |
| » W: Burt Hooton (10-7) L: Silvio Martinez (4-4) S: Terry Forster (12) | Sixth | 16½ out |
| Saturday, July 22 |
| » Lost to Dodgers (56-41), 4-3 | Dodger Stadium (2-3) | 38-60 | Lost 2 |
| » W: Tommy John (11-7) L: John Denny (8-7) S: Terry Forster (13) | Sixth | 17½ out |
| Sunday, July 23 |
| » Defeated Dodgers (56-42), 2-0 | Dodger Stadium (3-3) | 39-60 | |
| » W: Pete Vuckovich (8-7) L: Don Sutton (10-9) | Sixth | 17½ out |
| Tuesday, July 25 |
| » Lost to Giants (61-39), 3-2 | Candlestick Park (0-5) | 39-61 | |
| » W: Vida Blue (14-4) L: Bob Forsch (9-10) | Sixth | 17 out |
| Wednesday, July 26 |
| » Defeated Giants (61-40), 2-1 | Candlestick Park (1-5) | 40-61 | |
| » W: Silvio Martinez (5-4) L: Ed Halicki (5-4) | Sixth | 16 out |
| Friday, July 28 |
| » Lost to Padres (51-52), 8-3 | San Diego/Jack Murphy Stadium (0-4) | 40-62 | |
| » W: Randy Jones (8-9) L: John Denny (8-8) | Sixth | 16½ out |
| Saturday, July 29 |
| » Lost to Padres (52-52), 7-3 | San Diego/Jack Murphy Stadium (0-5) | 40-63 | Lost 2 |
| » W: Bob Owchinko (7-7) L: Pete Vuckovich (8-8) | Sixth | 16½ out |
| Sunday, July 30 |
| » Lost to Padres (53-52), 3-2 | San Diego/Jack Murphy Stadium (0-6) | 40-64 | Lost 3 |
| » W: Gaylord Perry (12-4) L: Bob Forsch (9-11) S: Rollie Fingers (23) | Sixth | 16½ out |
| Tuesday, August 1 |
| » Lost to Cubs (52-51), 4-2 | Wrigley Field (0-4) | 40-65 | Lost 4 |
| » W: Dennis Lamp (5-10) L: Silvio Martinez (5-5) S: Bruce Sutter (18) | Sixth | 17 out |
| Wednesday, August 2 |
| » Lost to Cubs (53-51), 3-2 | Wrigley Field (0-5) | 40-66 | Lost 5 |
| » W: Mike Krukow (5-0) L: Aurelio Lopez (0-1) S: Bruce Sutter (19) | Sixth | 18 out |
| Thursday, August 3 |
| » Lost to Cubs (54-51), 3-2 | Wrigley Field (0-6) | 40-67 | Lost 6 |
| » W: Donnie Moore (6-4) L: Pete Vuckovich (8-9) | Sixth | 18½ out |
| Friday, August 4 |
| » Lost to Mets (47-63), 8-3 | Busch Stadium II (21-30) | 40-68 | Lost 7 |
| » W: Craig Swan (4-5) L: Bob Forsch (9-12) | Sixth | 19 out |
| Saturday, August 5 |
| » Defeated Mets (47-64), 5-3 | Busch Stadium II (22-30) | 41-68 | |
| » W: Tom Bruno (1-0) L: Nino Espinosa (9-10) S: Mark Littell (5) | Sixth | 18½ out |
| Former Cardinal Jesse Haines dies in Dayton, OH at the age of 86. |
| Sunday, August 6 |
| » Defeated Mets (47-65), 3-1 | Busch Stadium II (23-30) | 42-68 | Won 2 |
| » W: Silvio Martinez (6-5) L: Jerry Koosman (3-13) S: Roy Thomas (3) | Sixth | 19 out |
| Monday, August 7 |
| » Defeated Phillies (59-48), 6-3 | Busch Stadium II (24-30) | 43-68 | Won 3 |
| » W: Aurelio Lopez (1-1) L: Randy Lerch (6-7) S: Mark Littell (6) | Sixth | 18 out |
| Tuesday, August 8 |
| » Defeated Phillies (59-49), 2-0 | Busch Stadium II (25-30) | 44-68 | Won 4 |
| » W: Pete Vuckovich (9-9) L: Larry Christenson (8-11) | Sixth | 16 out |
| » Defeated Phillies (59-50), 6-2 | Busch Stadium II (26-30) | 45-68 | Won 5 |
| » W: Tom Bruno (2-0) L: Jim Lonborg (7-10) | Sixth | 16 out |
| Wednesday, August 9 |
| » Lost to Phillies (60-50), 6-3 | Busch Stadium II (26-31) | 45-69 | |
| » W: Jim Kaat (6-4) L: Bob Forsch (9-13) S: Ron Reed (9) | Sixth | 17 out |
| Friday, August 11 |
| » Defeated Mets (48-67), 4-1 | Shea Stadium (4-1) | 46-69 | |
| » W: Aurelio Lopez (2-1) L: Dale Murray (5-5) S: Tom Bruno (1) | Sixth | 17½ out |
| Saturday, August 12 |
| » Defeated Mets (48-68), 5-1 | Shea Stadium (5-1) | 47-69 | Won 2 |
| » W: John Denny (9-8) L: Kevin Kobel (2-3) | Sixth | 17½ out |
| Sunday, August 13 |
| » Defeated Mets (48-69), 6-1 | Shea Stadium (6-1) | 48-69 | Won 3 |
| » W: Pete Vuckovich (10-9) L: Mike Bruhert (2-6) | Fifth | 16½ out |
| Monday, August 14 |
| » Lost to Astros (55-61), 6-0 | Busch Stadium II (26-32) | 48-70 | |
| » W: Tom Dixon (6-9) L: Bob Forsch (9-14) | Sixth | 17 out |
| Tuesday, August 15 |
| » Defeated Astros (55-62), 11-5 | Busch Stadium II (27-32) | 49-70 | |
| » W: Aurelio Lopez (3-1) L: Floyd Bannister (3-7) | Sixth | 16 out |
| Wednesday, August 16 |
| » Lost to Astros (56-62), 4-2 | Busch Stadium II (27-33) | 49-71 | |
| » W: Joe Niekro (10-9) L: Silvio Martinez (6-6) | Sixth | 16 out |
| Thursday, August 17 |
| » Defeated Braves (55-65), 4-3 | Busch Stadium II (28-33) | 50-71 | |
| » W: John Denny (10-8) L: Mickey Mahler (4-7) S: Mark Littell (7) | Fifth | 15 out |
| Friday, August 18 |
| » Defeated Braves (55-66), 5-1 | Busch Stadium II (29-33) | 51-71 | Won 2 |
| » W: Pete Vuckovich (11-9) L: Preston Hanna (7-12) | Fifth | 14 out |
| » Major-league debuts: Bruce Benedict (Braves) |
| Former Cardinal George Harper dies in Magnolia, AR at the age of 87. |
| Saturday, August 19 |
| » Lost to Braves (56-66), 3-0 | Busch Stadium II (29-34) | 51-72 | |
| » W: Larry McWilliams (6-0) L: Bob Forsch (9-15) | Fifth | 15 out |
| Sunday, August 20 |
| » Defeated Braves (56-67), 6-4 | Busch Stadium II (30-34) | 52-72 | |
| » W: Tom Bruno (3-0) L: Phil Niekro (15-13) | Fifth | 15 out |
| Monday, August 21 |
| » Defeated Reds (70-55), 14-9 | Riverfront Stadium (1-3) | 53-72 | Won 2 |
| » W: Silvio Martinez (7-6) L: Bill Bonham (9-4) | Fifth | 14 out |
| Tuesday, August 22 |
| » Lost to Reds (71-55), 5-4 | Riverfront Stadium (1-4) | 53-73 | |
| » W: Dave Tomlin (7-1) L: Tom Bruno (3-1) | Fifth | 15 out |
| Thursday, August 24 |
| » Defeated Reds (71-56), 4-3 | Riverfront Stadium (2-4) | 54-73 | |
| » W: Pete Vuckovich (12-9) L: Paul Moskau (3-4) | Fourth | 13½ out |
| Friday, August 25 |
| » Defeated Braves (56-71), 11-10 | Atlanta-Fulton County Stadium (1-3) | 55-73 | Won 2 |
| » W: Tom Bruno (4-1) L: Gene Garber (3-3) S: Mark Littell (8) | Fifth | 12½ out |
| Saturday, August 26 |
| » Defeated Braves (56-72), 9-4 | Atlanta-Fulton County Stadium (2-3) | 56-73 | Won 3 |
| » W: Silvio Martinez (8-6) L: Preston Hanna (7-13) | Fifth | 12½ out |
| Sunday, August 27 |
| » Defeated Braves (56-73), 14-3 | Atlanta-Fulton County Stadium (3-3) | 57-73 | Won 4 |
| » W: John Denny (11-8) L: Mickey Mahler (4-9) | Fifth | 12½ out |
| Tuesday, August 29 |
| » Lost to Astros (62-69), 6-3 | Astrodome (2-3) | 57-74 | |
| » W: Ken Forsch (8-4) L: Pete Vuckovich (12-10) | Fourth | 14 out |
| Wednesday, August 30 |
| » Defeated Astros (62-70), 4-2 | Astrodome (3-3) | 58-74 | |
| » W: Bob Forsch (10-15) L: Joe Niekro (11-11) | Fifth | 14 out |
| Thursday, August 31 |
| » Lost to Reds (72-61), 11-6 | Busch Stadium II (30-35) | 58-75 | |
| » W: Tom Seaver (12-13) L: Silvio Martinez (8-7) | Fifth | 14½ out |
| Friday, September 1 |
| » Lost to Reds (73-61), 5-2 | Busch Stadium II (30-36) | 58-76 | Lost 2 |
| » W: Paul Moskau (4-4) L: John Denny (11-9) S: Doug Bair (22) | Fifth | 14½ out |
| Saturday, September 2 |
| » Lost to Reds (74-61), 6-3 | Busch Stadium II (30-37) | 58-77 | Lost 3 |
| » W: Pedro Borbon (7-2) L: Mark Littell (1-8) S: Doug Bair (23) | Fifth | 15½ out |
| Sunday, September 3 |
| » Defeated Reds (74-62), 10-2 | Busch Stadium II (31-37) | 59-77 | |
| » W: Pete Falcone (2-6) L: Mike LaCoss (3-6) | Fifth | 14 out |
| Monday, September 4 |
| » Defeated Phillies (72-63), 3-2 | Busch Stadium II (32-37) | 60-77 | Won 2 |
| » W: Bob Forsch (11-15) L: Randy Lerch (8-8) S: Mark Littell (9) | Fifth | 14 out |
| » Lost to Phillies (73-63), 10-2 | Busch Stadium II (32-38) | 60-78 | |
| » W: Jim Lonborg (8-10) L: Silvio Martinez (8-8) | Fifth | 14 out |
| » Major-league debuts: Terry Kennedy and Mike Ramsey (Cardinals) Todd Cruz (Phillies) |
| Wednesday, September 6 |
| » Lost to Pirates (74-64), 4-1 | Busch Stadium II (32-39) | 60-79 | Lost 2 |
| » W: Don Robinson (12-5) L: John Denny (11-10) | Fifth | 15 out |
| Thursday, September 7 |
| » Defeated Pirates (74-65), 5-4 | Busch Stadium II (33-39) | 61-79 | |
| » W: Aurelio Lopez (4-1) L: Grant Jackson (7-4) S: Mark Littell (10) | Fifth | 15 out |
| Friday, September 8 |
| » Lost to Phillies (76-63), 1-0 | Veteran's Stadium (2-4) | 61-80 | |
| » W: Dick Ruthven (13-10) L: Tom Bruno (4-2) | Fifth | 17 out |
| » Lost to Phillies (77-63), 2-1 | Veteran's Stadium (2-5) | 61-81 | Lost 2 |
| » W: Ron Reed (2-2) L: Dan O'Brien (0-1) | Fifth | 17 out |
| Saturday, September 9 |
| » Lost to Phillies (78-63), 6-3 | Veteran's Stadium (2-6) | 61-82 | Lost 3 |
| » W: Randy Lerch (9-8) L: Bob Forsch (11-16) | Fifth | 18 out |
| Sunday, September 10 |
| » Defeated Phillies (78-64), 8-6 | Veteran's Stadium (3-6) | 62-82 | |
| » W: Mark Littell (2-8) L: Ron Reed (2-3) S: Buddy Schultz (6) | Fifth | 17 out |
| Monday, September 11 |
| » Lost to Expos (68-77), 3-1 | Stade Olympique (5-3) | 62-83 | |
| » W: Ross Grimsley (18-9) L: John Denny (11-11) | Fifth | 18 out |
| Tuesday, September 12 |
| » Lost to Expos (69-77), 5-1 | Stade Olympique (5-4) | 62-84 | Lost 2 |
| » W: Rudy May (7-9) L: Pete Vuckovich (12-11) | Fifth | 18 out |
| Wednesday, September 13 |
| » Lost to Pirates (76-69), 7-1 | Three Rivers Stadium (3-5) | 62-85 | Lost 3 |
| » W: Bert Blyleven (13-9) L: Pete Falcone (2-7) | Fifth | 19 out |
| Thursday, September 14 |
| » Lost to Pirates (77-69), 7-4 | Three Rivers Stadium (3-6) | 62-86 | Lost 4 |
| » W: Jim Rooker (9-10) L: Bob Forsch (11-17) | Fifth | 20 out |
| Friday, September 15 |
| » Defeated Cubs (73-74), 6-2 | Wrigley Field (1-6) | 63-86 | |
| » W: Mark Littell (3-8) L: Bruce Sutter (8-8) | Fifth | 19 out |
| Saturday, September 16 |
| » Defeated Cubs (73-75), 4-1 | Wrigley Field (2-6) | 64-86 | Won 2 |
| » W: John Denny (12-11) L: Dennis Lamp (7-14) S: Mark Littell (11) | Fifth | 19 out |
| Sunday, September 17 |
| » Lost to Cubs (74-75), 4-2 | Wrigley Field (2-7) | 64-87 | |
| » W: Ray Burris (6-12) L: Pete Vuckovich (12-12) | Fifth | 19 out |
| Tuesday, September 19 |
| » Defeated Mets (62-89), 5-3 | Busch Stadium II (34-39) | 65-87 | |
| » W: Mark Littell (4-8) L: Dale Murray (9-6) | Fifth | 18 out |
| Wednesday, September 20 |
| » Lost to Mets (63-89), 7-6 | Busch Stadium II (34-40) | 65-88 | |
| » W: Kevin Kobel (4-5) L: George Frazier (0-3) S: Jerry Koosman (1) | Fifth | 19 out |
| Thursday, September 21 |
| » Defeated Mets (63-90), 6-2 | Busch Stadium II (35-40) | 66-88 | |
| » W: John Urrea (4-9) L: Craig Swan (8-6) | Fifth | 18½ out |
| Friday, September 22 |
| » Lost to Cubs (76-77), 5-3 | Busch Stadium II (35-41) | 66-89 | |
| » W: Ray Burris (7-12) L: Aurelio Lopez (4-2) S: Dave Roberts (1) | Fifth | 19 out |
| Saturday, September 23 |
| » Defeated Cubs (76-78), 5-1 | Busch Stadium II (36-41) | 67-89 | |
| » W: John Denny (13-11) L: Rick Reuschel (14-14) | Fifth | 19½ out |
| Sunday, September 24 |
| » Lost to Cubs (77-78), 5-4 | Busch Stadium II (36-42) | 67-90 | |
| » W: Lynn McGlothen (5-2) L: Tom Bruno (4-3) S: Bruce Sutter (26) | Fifth | 20½ out |
| Monday, September 25 |
| » Defeated Mets (63-94), 3-0 | Shea Stadium (7-1) | 68-90 | |
| » W: Silvio Martinez (9-8) L: Kevin Kobel (4-6) | Fifth | 20½ out |
| Tuesday, September 26 |
| » Lost to Mets (64-94), 3-1 | Shea Stadium (7-2) | 68-91 | |
| » W: Craig Swan (9-6) L: Rob Dressler (0-1) S: Dale Murray (6) | Fifth | 21 out |
| Friday, September 29 |
| » Lost to Expos (75-85), 7-5 | Busch Stadium II (36-43) | 68-92 | Lost 2 |
| » W: Darold Knowles (3-3) L: Buddy Schultz (2-4) S: Woodie Fryman (1) | Fifth | 21 out |
| Saturday, September 30 |
| » Defeated Expos (75-86), 6-1 | Busch Stadium II (37-43) | 69-92 | |
| » W: John Denny (14-11) L: Dan Schatzeder (7-7) | Fifth | 21 out |
| Sunday, October 1 |
| » Lost to Expos (76-86), 5-1 | Busch Stadium II (37-44) | 69-93 | |
| » W: Ross Grimsley (20-11) L: Dan O'Brien (0-2) | Fifth | 21 out |
| Thursday, November 2 |
| Future Cardinal Carmen Cali is born in Cleveland, OH. |
| Saturday, December 9 |
| Former Cardinal Dick Siebert dies in Minneapolis, MN at the age of 67. |
Game information provided by Retrosheet (www.retrosheet.org) |