| Thursday, February 23 |
| Future Blue Jay Luke Prokopec is born in Blackwood, Australia. |
| Friday, February 24 |
| Future Blue Jay Dewayne Wise is born in Columbia, SC. |
| Wednesday, April 5 |
| » Major-league debuts: Hosken Powell (Twins) |
| Friday, April 7 |
| » Lost to Tigers (1-0), 6-2 | Tiger Stadium (0-1) | 0-1 | |
| » W: Mark Fidrych (1-0) L: Dave Lemanczyk (0-1) | Third | 1 out |
| Saturday, April 8 |
| » Defeated Tigers (1-1), 5-2 | Tiger Stadium (1-1) | 1-1 | |
| » W: Jerry Garvin (1-0) L: Jim Slaton (0-1) S: Mike Willis (1) | Third | 1 out |
| Sunday, April 9 |
| » Lost to Tigers (2-1), 8-4 | Tiger Stadium (1-2) | 1-2 | |
| » W: Jack Billingham (1-0) L: Tom Underwood (0-1) S: Steve Foucault (1) | Fourth | 2 out |
| » Major-league debuts: Garth Iorg and Willie Upshaw (Blue Jays) |
| Monday, April 10 |
| » Major-league debuts: Allen Ripley (Red Sox) |
| Tuesday, April 11 |
| » Lost to White Sox (3-1), 9-5 | Comiskey Park I (0-1) | 1-3 | Lost 2 |
| » W: Ken Kravec (1-0) L: Jesse Jefferson (0-1) S: Pablo Torrealba (1) | Fourth | 3 out |
| Wednesday, April 12 |
| » Lost to White Sox (4-1), 5-4 | Comiskey Park I (0-2) | 1-4 | Lost 3 |
| » W: Steve Stone (1-0) L: Dave Lemanczyk (0-2) S: Lerrin LaGrow (2) | Fifth | 4 out |
| Friday, April 14 |
| » Defeated Tigers (4-2), 10-8 | Exhibition Stadium (1-0) | 2-4 | |
| » W: Don Kirkwood (1-0) L: Milt Wilcox (0-1) S: Tom Murphy (1) | Fifth | 3 out |
| Saturday, April 15 |
| » Lost to Tigers (5-2), 6-3 | Exhibition Stadium (1-1) | 2-5 | |
| » W: Jack Billingham (2-0) L: Mike Willis (0-1) S: Steve Foucault (2) | Fifth | 3 out |
| Sunday, April 16 |
| » Lost to Tigers (6-2), 4-3 | Exhibition Stadium (1-2) | 2-6 | Lost 2 |
| » W: Jim Crawford (1-0) L: Jim Clancy (0-1) | Seventh | 4 out |
| Monday, April 17 |
| » Lost to Royals (7-1), 3-1 | Exhibition Stadium (1-3) | 2-7 | Lost 3 |
| » W: Larry Gura (1-0) L: Jesse Jefferson (0-2) S: Al Hrabosky (3) | Seventh | 5 out |
| Tuesday, April 18 |
| » Lost to Royals (8-1), 5-0 | Exhibition Stadium (1-4) | 2-8 | Lost 4 |
| » W: Paul Splittorff (3-0) L: Dave Lemanczyk (0-3) | Seventh | 5½ out |
| Wednesday, April 19 |
| » Defeated Yankees (5-6), 4-3 | Exhibition Stadium (2-4) | 3-8 | |
| » W: Tom Murphy (1-0) L: Rich Gossage (0-3) | Seventh | 5 out |
| Friday, April 21 |
| » Lost to White Sox (5-5), 11-2 | Exhibition Stadium (2-5) | 3-9 | |
| » W: Francisco Barrios (1-1) L: Tom Underwood (0-2) S: Lerrin LaGrow (3) | Sixth | 5½ out |
| Saturday, April 22 |
| » Defeated White Sox (5-6), 4-2 | Exhibition Stadium (3-5) | 4-9 | |
| » W: Jim Clancy (1-1) L: Wilbur Wood (0-3) S: Mike Willis (2) | Seventh | 5½ out |
| Sunday, April 23 |
| » Defeated White Sox (5-7), 4-0 | Exhibition Stadium (4-5) | 5-9 | Won 2 |
| » W: Jesse Jefferson (1-2) L: Steve Stone (1-1) | Sixth | 5 out |
| Monday, April 24 |
| » Lost to Indians (6-7), 4-2 | Exhibition Stadium (4-6) | 5-10 | |
| » W: Don Hood (1-0) L: Dave Lemanczyk (0-4) S: Jim Kern (1) | Sixth | 6 out |
| Tuesday, April 25 |
| » Lost to Indians (7-7), 6-5 | Exhibition Stadium (4-7) | 5-11 | Lost 2 |
| » W: Wayne Garland (2-2) L: Jerry Garvin (1-1) S: Dennis Kinney (2) | Fifth | 7 out |
| Wednesday, April 26 |
| » Defeated Royals (11-4), 3-1 | Royals Stadium (1-0) | 6-11 | |
| » W: Tom Murphy (2-0) L: Paul Splittorff (4-1) | Sixth | 6 out |
| Thursday, April 27 |
| » Defeated Royals (11-5), 8-7 | Royals Stadium (2-0) | 7-11 | Won 2 |
| » W: Balor Moore (1-0) L: Doug Bird (1-1) S: Mike Willis (3) | Sixth | 5½ out |
| Friday, April 28 |
| » Lost to Angels (13-6), 5-4 | Anaheim Stadium (0-1) | 7-12 | |
| » W: Dyar Miller (1-0) L: Jesse Jefferson (1-3) S: Dave LaRoche (5) | Sixth | 6½ out |
| Saturday, April 29 |
| » Lost to Angels (14-6), 5-0 | Anaheim Stadium (0-2) | 7-13 | Lost 2 |
| » W: Nolan Ryan (1-1) L: Dave Lemanczyk (0-5) | Seventh | 7½ out |
| Sunday, April 30 |
| » Defeated Angels (14-7), 9-3 | Anaheim Stadium (1-2) | 8-13 | |
| » W: Jerry Garvin (2-1) L: Chris Knapp (3-2) | Sixth | 6½ out |
| Tuesday, May 2 |
| » Lost to Athletics (17-5), 2-1 | Oakland-Alameda County Stadium (0-1) | 8-14 | |
| » W: Matt Keough (2-0) L: Tom Underwood (0-3) S: Elias Sosa (4) | Sixth | 7½ out |
| Wednesday, May 3 |
| » Lost to Athletics (18-5), 11-3 | Oakland-Alameda County Stadium (0-2) | 8-15 | Lost 2 |
| » W: Pete Broberg (4-0) L: Jim Clancy (1-2) S: Bob Lacey (2) | Seventh | 8½ out |
| Friday, May 5 |
| » Lost to Mariners (9-20), 9-1 | Kingdome (0-1) | 8-16 | Lost 3 |
| » W: Rick Honeycutt (2-3) L: Jesse Jefferson (1-4) | Seventh | 8½ out |
| Saturday, May 6 |
| » Lost to Mariners (10-20), 6-0 | Kingdome (0-2) | 8-17 | Lost 4 |
| » W: Paul Mitchell (2-3) L: Dave Lemanczyk (0-6) | Seventh | 9½ out |
| Sunday, May 7 |
| » Lost to Mariners (11-20), 9-7 | Kingdome (0-3) | 8-18 | Lost 5 |
| » W: Enrique Romo (3-0) L: Mike Willis (0-2) | Seventh | 10½ out |
| Tuesday, May 9 |
| » Defeated Athletics (19-8), 4-0 | Exhibition Stadium (5-7) | 9-18 | |
| » W: Tom Underwood (1-3) L: Pete Broberg (4-1) | Seventh | 9½ out |
| Wednesday, May 10 |
| » Defeated Athletics (19-9), 3-1 | Exhibition Stadium (6-7) | 10-18 | Won 2 |
| » W: Jim Clancy (2-2) L: Rick Langford (0-2) | Seventh | 9 out |
| Friday, May 12 |
| » Defeated Mariners (11-23), 8-3 | Exhibition Stadium (7-7) | 11-18 | Won 3 |
| » W: Jesse Jefferson (2-4) L: Shane Rawley (0-3) | Seventh | 8 out |
| Future Blue Jay Josh Phelps is born in Anchorage, AK. |
| Saturday, May 13 |
| » Lost to Mariners (12-23), 9-6 | Exhibition Stadium (7-8) | 11-19 | |
| » W: Dick Pole (3-4) L: Dave Lemanczyk (0-7) S: Enrique Romo (3) | Seventh | 9 out |
| Monday, May 15 |
| » Defeated Angels (19-12), 10-6 | Exhibition Stadium (8-8) | 12-19 | |
| » W: Balor Moore (2-0) L: Paul Hartzell (0-3) | Seventh | 8½ out |
| Future Blue Jay Clayton Andrews is born in Dunedin, FL. |
| Tuesday, May 16 |
| » Defeated Angels (19-13), 5-4 | Exhibition Stadium (9-8) | 13-19 | Won 2 |
| » W: Mike Willis (1-2) L: Don Aase (2-2) S: Tom Murphy (2) | Sixth | 8½ out |
| Thursday, May 18 |
| » Lost to Orioles (14-19), 5-3 | Memorial Stadium (0-1) | 13-20 | |
| » W: Mike Flanagan (4-3) L: Jim Clancy (2-3) | Seventh | 9 out |
| Friday, May 19 |
| » Lost to Yankees (21-13), 11-3 | Exhibition Stadium (9-9) | 13-21 | Lost 2 |
| » W: Dick Tidrow (2-3) L: Jesse Jefferson (2-5) | Seventh | 10 out |
| Saturday, May 20 |
| » Defeated Yankees (21-14), 10-8 | Exhibition Stadium (10-9) | 14-21 | |
| » W: Dave Lemanczyk (1-7) L: Ken Clay (0-2) | Seventh | 9 out |
| Sunday, May 21 |
| » Lost to Yankees (22-14), 2-1 | Exhibition Stadium (10-10) | 14-22 | |
| » W: Ed Figueroa (5-1) L: Tom Underwood (1-4) S: Rich Gossage (6) | Sixth | 10 out |
| » Lost to Yankees (23-14), 9-1 | Exhibition Stadium (10-11) | 14-23 | Lost 2 |
| » W: Ken Clay (1-2) L: Jerry Garvin (2-2) | Sixth | 10 out |
| Monday, May 22 |
| » Lost to Red Sox (26-14), 5-4 | Exhibition Stadium (10-12) | 14-24 | Lost 3 |
| » W: Allen Ripley (1-3) L: Jim Clancy (2-4) S: Bob Stanley (3) | Sixth | 10½ out |
| Tuesday, May 23 |
| » Defeated Red Sox (26-15), 2-1 | Exhibition Stadium (11-12) | 15-24 | |
| » W: Jesse Jefferson (3-5) L: Bill Campbell (2-4) | Seventh | 9½ out |
| Wednesday, May 24 |
| » Lost to Red Sox (27-15), 8-2 | Exhibition Stadium (11-13) | 15-25 | |
| » W: Mike Torrez (6-2) L: Dave Lemanczyk (1-8) | Sixth | 11 out |
| Thursday, May 25 |
| » Lost to Red Sox (28-15), 9-5 | Exhibition Stadium (11-14) | 15-26 | Lost 2 |
| » W: Dennis Eckersley (4-1) L: Tom Underwood (1-5) S: Dick Drago (4) | Seventh | 12 out |
| Friday, May 26 |
| » Lost to Yankees (26-14), 4-3 | Yankee Stadium (0-1) | 15-27 | Lost 3 |
| » W: Sparky Lyle (3-1) L: Jerry Garvin (2-3) | Seventh | 13 out |
| Saturday, May 27 |
| » Defeated Yankees (26-15), 4-1 | Yankee Stadium (1-1) | 16-27 | |
| » W: Jim Clancy (3-4) L: Ed Figueroa (5-2) S: Tom Murphy (3) | Seventh | 13 out |
| Sunday, May 28 |
| » Lost to Yankees (27-15), 5-3 | Yankee Stadium (1-2) | 16-28 | |
| » W: Ron Guidry (7-0) L: Jesse Jefferson (3-6) | Seventh | 15 out |
| » Lost to Yankees (28-15), 6-5 | Yankee Stadium (1-3) | 16-29 | Lost 2 |
| » W: Rich Gossage (3-4) L: Tom Murphy (2-1) | Seventh | 15 out |
| Monday, May 29 |
| » Lost to Red Sox (33-15), 5-4 | Fenway Park (0-1) | 16-30 | Lost 3 |
| » W: Mike Torrez (7-2) L: Tom Underwood (1-6) | Seventh | 16 out |
| Tuesday, May 30 |
| » Lost to Red Sox (34-15), 4-0 | Fenway Park (0-2) | 16-31 | Lost 4 |
| » W: Dennis Eckersley (5-1) L: Jerry Garvin (2-4) | Seventh | 17 out |
| Wednesday, May 31 |
| » Defeated Red Sox (34-16), 6-2 | Fenway Park (1-2) | 17-31 | |
| » W: Jim Clancy (4-4) L: Bill Lee (7-2) | Seventh | 16 out |
| Friday, June 2 |
| » Defeated Rangers (24-23), 3-1 | Exhibition Stadium (12-14) | 18-31 | Won 2 |
| » W: Jesse Jefferson (4-6) L: Jon Matlack (5-6) | Seventh | 16 out |
| Saturday, June 3 |
| » Defeated Rangers (24-24), 4-3 | Exhibition Stadium (13-14) | 19-31 | Won 3 |
| » W: Tom Underwood (2-6) L: Jim Umbarger (2-5) S: Tom Murphy (4) | Seventh | 16 out |
| Sunday, June 4 |
| » Lost to Rangers (25-24), 9-5 | Exhibition Stadium (13-15) | 19-32 | |
| » W: Dock Ellis (4-2) L: Dave Lemanczyk (1-9) S: Steve Comer (1) | Seventh | 16 out |
| Friday, June 9 |
| » Lost to Brewers (27-26), 3-2 | County Stadium (0-1) | 19-33 | Lost 2 |
| » W: Mike Caldwell (6-3) L: Tom Murphy (2-2) | Seventh | 16 out |
| Saturday, June 10 |
| » Lost to Brewers (28-26), 5-0 | County Stadium (0-2) | 19-34 | Lost 3 |
| » W: Bill Travers (3-2) L: Jerry Garvin (2-5) | Seventh | 17 out |
| Sunday, June 11 |
| » Lost to Brewers (29-26), 2-1 | County Stadium (0-3) | 19-35 | Lost 4 |
| » W: Lary Sorensen (8-4) L: Tom Underwood (2-7) | Seventh | 18½ out |
| » Lost to Brewers (30-26), 5-4 | County Stadium (0-4) | 19-36 | Lost 5 |
| » W: Randy Stein (2-1) L: Tom Murphy (2-3) | Seventh | 18½ out |
| Tuesday, June 13 |
| » Lost to Twins (22-35), 2-0 | Exhibition Stadium (13-16) | 19-37 | Lost 6 |
| » W: Dave Goltz (3-4) L: Balor Moore (2-1) S: Mike Marshall (8) | Seventh | 20½ out |
| » Lost to Twins (23-35), 7-2 | Exhibition Stadium (13-17) | 19-38 | Lost 7 |
| » W: Geoff Zahn (6-4) L: Jim Clancy (4-5) | Seventh | 20½ out |
| Wednesday, June 14 |
| » Lost to Brewers (33-26), 7-5 | Exhibition Stadium (13-18) | 19-39 | Lost 8 |
| » W: Bill Castro (2-0) L: Tom Murphy (2-4) | Seventh | 22 out |
| » Lost to Brewers (34-26), 5-0 | Exhibition Stadium (13-19) | 19-40 | Lost 9 |
| » W: Jerry Augustine (6-8) L: Jerry Garvin (2-6) | Seventh | 22 out |
| Friday, June 16 |
| » Defeated Rangers (30-30), 8-3 | Arlington Stadium (1-0) | 20-40 | |
| » W: Tom Underwood (3-7) L: Dock Ellis (5-3) | Seventh | 22 out |
| » Defeated Rangers (30-31), 5-2 | Arlington Stadium (2-0) | 21-40 | Won 2 |
| » W: Jesse Jefferson (5-6) L: Roger Moret (0-1) S: Tom Murphy (5) | Seventh | 22 out |
| Saturday, June 17 |
| » Lost to Rangers (31-31), 13-2 | Arlington Stadium (2-1) | 21-41 | |
| » W: Fergie Jenkins (7-3) L: Jim Clancy (4-6) | Seventh | 23 out |
| Sunday, June 18 |
| » Lost to Rangers (32-31), 3-2 | Arlington Stadium (2-2) | 21-42 | Lost 2 |
| » W: Reggie Cleveland (2-3) L: Tom Murphy (2-5) | Seventh | 23 out |
| Tuesday, June 20 |
| » Lost to Tigers (32-31), 4-3 | Exhibition Stadium (13-20) | 21-43 | Lost 3 |
| » W: John Hiller (6-3) L: Mike Willis (1-3) | Seventh | 23½ out |
| Wednesday, June 21 |
| » Lost to Tigers (33-31), 10-8 | Exhibition Stadium (13-21) | 21-44 | Lost 4 |
| » W: Jim Crawford (2-2) L: Don Kirkwood (1-1) S: Steve Foucault (4) | Sixth | 24½ out |
| Friday, June 23 |
| » Lost to Indians (29-36), 8-3 | Cleveland Stadium (0-1) | 21-45 | Lost 5 |
| » W: Rick Waits (5-7) L: Jesse Jefferson (5-7) | Sixth | 25½ out |
| » Major-league debuts: Brian Milner (Blue Jays) |
| Saturday, June 24 |
| » Lost to Indians (30-36), 12-3 | Cleveland Stadium (0-2) | 21-46 | Lost 6 |
| » W: Mike Paxton (4-4) L: Jim Clancy (4-7) | Sixth | 26½ out |
| » Major-league debuts: Victor Cruz (Blue Jays) |
| Sunday, June 25 |
| » Defeated Indians (30-37), 2-1 | Cleveland Stadium (1-2) | 22-46 | |
| » W: Balor Moore (3-1) L: David Clyde (4-3) S: Victor Cruz (1) | Seventh | 27 out |
| » Lost to Indians (31-37), 3-2 | Cleveland Stadium (1-3) | 22-47 | |
| » W: Rick Wise (5-10) L: Jerry Garvin (2-7) S: Sid Monge (2) | Seventh | 27 out |
| Monday, June 26 |
| » Defeated Orioles (40-31), 24-10 | Exhibition Stadium (14-21) | 23-47 | |
| » W: Tom Underwood (4-7) L: Mike Flanagan (11-5) | Sixth | 27 out |
| Tuesday, June 27 |
| » Defeated Orioles (40-32), 6-2 | Exhibition Stadium (15-21) | 24-47 | Won 2 |
| » W: Dave Lemanczyk (2-9) L: Jim Palmer (10-6) S: Victor Cruz (2) | Seventh | 25½ out |
| » Defeated Orioles (40-33), 9-8 | Exhibition Stadium (16-21) | 25-47 | Won 3 |
| » W: Victor Cruz (1-0) L: Don Stanhouse (1-5) | Seventh | 25½ out |
| Wednesday, June 28 |
| » Defeated Orioles (40-34), 3-2 | Exhibition Stadium (17-21) | 26-47 | Won 4 |
| » W: Jim Clancy (5-7) L: Scott McGregor (8-6) S: Tom Murphy (6) | Seventh | 25 out |
| Friday, June 30 |
| » Lost to Indians (35-39), 3-0 | Exhibition Stadium (17-22) | 26-48 | |
| » W: Rick Wise (6-10) L: Jerry Garvin (2-8) | Seventh | 25½ out |
| Saturday, July 1 |
| » Defeated Indians (35-40), 9-3 | Exhibition Stadium (18-22) | 27-48 | |
| » W: Tom Underwood (5-7) L: Don Hood (4-4) S: Victor Cruz (3) | Seventh | 24½ out |
| Sunday, July 2 |
| » Lost to Indians (36-40), 2-0 | Exhibition Stadium (18-23) | 27-49 | |
| » W: Rick Waits (6-8) L: Dave Lemanczyk (2-10) S: Jim Kern (7) | Seventh | 24½ out |
| » Defeated Indians (36-41), 3-1 | Exhibition Stadium (19-23) | 28-49 | |
| » W: Jesse Jefferson (6-7) L: Dave Freisleben (0-5) | Seventh | 24½ out |
| Monday, July 3 |
| » Lost to Tigers (38-40), 6-5 | Tiger Stadium (1-3) | 28-50 | |
| » W: Milt Wilcox (5-7) L: Tom Murphy (2-6) | Seventh | 25½ out |
| Tuesday, July 4 |
| » Defeated Tigers (38-41), 9-2 | Tiger Stadium (2-3) | 29-50 | |
| » W: Balor Moore (4-1) L: Jack Morris (1-4) | Sixth | 25 out |
| Wednesday, July 5 |
| » Lost to Orioles (44-36), 3-1 | Memorial Stadium (0-2) | 29-51 | |
| » W: Mike Flanagan (12-5) L: Jerry Garvin (2-9) | Sixth | 26½ out |
| » Lost to Orioles (45-36), 8-6 | Memorial Stadium (0-3) | 29-52 | Lost 2 |
| » W: Joe Kerrigan (1-0) L: Tom Murphy (2-7) | Sixth | 26½ out |
| Thursday, July 6 |
| » Defeated Orioles (45-37), 2-0 | Memorial Stadium (1-3) | 30-52 | |
| » W: Dave Lemanczyk (3-10) L: Jim Palmer (10-7) S: Mike Willis (4) | Seventh | 26½ out |
| Friday, July 7 |
| » Defeated White Sox (37-45), 3-2 | Comiskey Park I (1-2) | 31-52 | Won 2 |
| » W: Joe Coleman (4-0) L: Rich Hinton (1-2) S: Victor Cruz (4) | Seventh | 25½ out |
| Saturday, July 8 |
| » Defeated White Sox (37-46), 3-0 | Comiskey Park I (2-2) | 32-52 | Won 3 |
| » W: Jim Clancy (6-7) L: Ken Kravec (7-6) S: Mike Willis (5) | Seventh | 26 out |
| Sunday, July 9 |
| » Lost to White Sox (38-46), 5-3 | Comiskey Park I (2-3) | 32-53 | |
| » W: Steve Stone (7-6) L: Tom Underwood (5-8) S: Jim Willoughby (11) | Seventh | 26 out |
| Thursday, July 13 |
| » Lost to Angels (47-40), 5-0 | Anaheim Stadium (1-3) | 32-54 | Lost 2 |
| » W: Don Aase (7-4) L: Dave Lemanczyk (3-11) | Seventh | 26 out |
| Friday, July 14 |
| » Lost to Angels (48-40), 3-2 | Anaheim Stadium (1-4) | 32-55 | Lost 3 |
| » W: Dyar Miller (4-0) L: Mike Willis (1-4) | Seventh | 26 out |
| Saturday, July 15 |
| » Lost to Athletics (45-45), 3-2 | Oakland-Alameda County Stadium (0-3) | 32-56 | Lost 4 |
| » W: Elias Sosa (6-2) L: Tom Underwood (5-9) | Seventh | 27 out |
| Sunday, July 16 |
| » Lost to Athletics (46-45), 8-5 | Oakland-Alameda County Stadium (0-4) | 32-57 | Lost 5 |
| » W: Elias Sosa (7-2) L: Mike Willis (1-5) S: Dave Heaverlo (7) | Seventh | 28½ out |
| Monday, July 17 |
| » Lost to Athletics (47-45), 5-3 | Oakland-Alameda County Stadium (0-5) | 32-58 | Lost 6 |
| » W: John Henry Johnson (7-5) L: Jerry Garvin (2-10) | Seventh | 29½ out |
| Tuesday, July 18 |
| » Defeated Mariners (32-62), 13-12 | Kingdome (1-3) | 33-58 | |
| » W: Tom Murphy (3-7) L: Dick Pole (4-11) | Seventh | 29 out |
| Wednesday, July 19 |
| » Lost to Mariners (33-62), 6-2 | Kingdome (1-4) | 33-59 | |
| » W: Rick Honeycutt (3-5) L: Jesse Jefferson (6-8) S: John Montague (2) | Seventh | 30 out |
| Friday, July 21 |
| » Lost to Athletics (49-46), 7-2 | Exhibition Stadium (19-24) | 33-60 | Lost 2 |
| » W: Steve Renko (4-4) L: Balor Moore (4-2) | Seventh | 29 out |
| » Defeated Athletics (49-47), 5-4 | Exhibition Stadium (20-24) | 34-60 | |
| » W: Tom Murphy (4-7) L: Bob Lacey (6-5) S: Victor Cruz (5) | Seventh | 29 out |
| Saturday, July 22 |
| » Defeated Athletics (49-48), 7-3 | Exhibition Stadium (21-24) | 35-60 | Won 2 |
| » W: Jim Clancy (7-7) L: John Henry Johnson (7-6) | Seventh | 28 out |
| Sunday, July 23 |
| » Lost to Athletics (50-48), 5-3 | Exhibition Stadium (21-25) | 35-61 | |
| » W: Rick Langford (3-7) L: Jerry Garvin (2-11) S: Dave Heaverlo (8) | Seventh | 28 out |
| Monday, July 24 |
| » Lost to Mariners (34-64), 1-0 | Exhibition Stadium (21-26) | 35-62 | Lost 2 |
| » W: Rick Honeycutt (4-5) L: Dave Lemanczyk (3-12) | Seventh | 29 out |
| » Lost to Mariners (35-64), 7-2 | Exhibition Stadium (21-27) | 35-63 | Lost 3 |
| » W: Jim Colborn (2-8) L: Jesse Jefferson (6-9) S: Enrique Romo (9) | Seventh | 29 out |
| Tuesday, July 25 |
| » Lost to Mariners (36-64), 4-2 | Exhibition Stadium (21-28) | 35-64 | Lost 4 |
| » W: Glenn Abbott (4-7) L: Tom Underwood (5-10) | Seventh | 29 out |
| Wednesday, July 26 |
| » Defeated Twins (42-54), 5-1 | Metropolitan Stadium (1-0) | 36-64 | |
| » W: Balor Moore (5-2) L: Dave Goltz (9-7) | Seventh | 28 out |
| Thursday, July 27 |
| » Lost to Twins (43-54), 6-3 | Metropolitan Stadium (1-1) | 36-65 | |
| » W: Stan Perzanowski (1-0) L: Jim Clancy (7-8) | Seventh | 28 out |
| Friday, July 28 |
| » Defeated Brewers (58-41), 3-2 | Exhibition Stadium (22-28) | 37-65 | |
| » W: Victor Cruz (2-0) L: Bill Castro (3-2) | Seventh | 27 out |
| Saturday, July 29 |
| » Defeated Brewers (58-42), 4-3 | Exhibition Stadium (23-28) | 38-65 | Won 2 |
| » W: Dave Lemanczyk (4-12) L: Lary Sorensen (12-8) S: Victor Cruz (6) | Seventh | 27 out |
| Sunday, July 30 |
| » Lost to Brewers (59-42), 10-5 | Exhibition Stadium (23-29) | 38-66 | |
| » W: Randy Stein (3-2) L: Tom Murphy (4-8) | Sixth | 27 out |
| Monday, July 31 |
| » Defeated Tigers (55-49), 8-7 | Exhibition Stadium (24-29) | 39-66 | |
| » W: Joe Coleman (5-0) L: Bob Sykes (5-5) | Sixth | 27 out |
| Tuesday, August 1 |
| » Lost to Tigers (56-49), 3-2 | Exhibition Stadium (24-30) | 39-67 | |
| » W: Jim Slaton (11-8) L: Jim Clancy (7-9) | Seventh | 27 out |
| Friday, August 4 |
| » Defeated Royals (58-47), 5-4 | Royals Stadium (3-0) | 40-67 | |
| » W: Victor Cruz (3-0) L: Al Hrabosky (4-5) | Seventh | 27 out |
| Saturday, August 5 |
| » Lost to Royals (59-47), 5-3 | Royals Stadium (3-1) | 40-68 | |
| » W: Larry Gura (9-2) L: Dave Lemanczyk (4-13) S: Steve Mingori (6) | Seventh | 28 out |
| Sunday, August 6 |
| » Lost to Royals (60-47), 12-5 | Royals Stadium (3-2) | 40-69 | Lost 2 |
| » W: Rich Gale (13-3) L: Balor Moore (5-3) | Sixth | 29 out |
| Monday, August 7 |
| » Defeated Orioles (60-50), 2-1 | Exhibition Stadium (25-30) | 41-69 | |
| » W: Jim Clancy (8-9) L: Dennis Martinez (8-9) | Seventh | 28½ out |
| Tuesday, August 8 |
| » Defeated Orioles (60-51), 5-3 | Exhibition Stadium (26-30) | 42-69 | Won 2 |
| » W: Tom Underwood (6-10) L: Mike Flanagan (14-10) S: Victor Cruz (7) | Seventh | 28½ out |
| Wednesday, August 9 |
| » Defeated White Sox (46-65), 8-0 | Exhibition Stadium (27-30) | 43-69 | Won 3 |
| » W: Jesse Jefferson (7-9) L: Steve Stone (9-8) | Seventh | 27½ out |
| Thursday, August 10 |
| » Defeated White Sox (46-66), 7-3 | Exhibition Stadium (28-30) | 44-69 | Won 4 |
| » W: Jerry Garvin (3-11) L: Wilbur Wood (10-10) S: Victor Cruz (8) | Seventh | 27½ out |
| Friday, August 11 |
| » Lost to Royals (63-49), 9-8 | Exhibition Stadium (28-31) | 44-70 | |
| » W: Al Hrabosky (5-5) L: Victor Cruz (3-1) | Seventh | 27½ out |
| Future Blue Jay Eric Crozier is born in Columbus, OH. |
| Saturday, August 12 |
| » Defeated Royals (63-50), 5-2 | Exhibition Stadium (29-31) | 45-70 | |
| » W: Jim Clancy (9-9) L: Paul Splittorff (13-10) | Sixth | 28 out |
| Sunday, August 13 |
| » Defeated Royals (63-51), 3-2 | Exhibition Stadium (30-31) | 46-70 | Won 2 |
| » W: Mike Willis (2-5) L: Al Hrabosky (5-6) | Seventh | 28 out |
| Tuesday, August 15 |
| » Lost to Brewers (64-52), 9-1 | County Stadium (0-5) | 46-71 | |
| » W: Jerry Augustine (11-11) L: Dave Lemanczyk (4-14) | Sixth | 27½ out |
| Wednesday, August 16 |
| » Lost to Brewers (65-52), 8-1 | County Stadium (0-6) | 46-72 | Lost 2 |
| » W: Mike Caldwell (15-7) L: Jesse Jefferson (7-10) | Seventh | 29 out |
| » Lost to Brewers (66-52), 3-2 | County Stadium (0-7) | 46-73 | Lost 3 |
| » W: Eduardo Rodriguez (4-5) L: Balor Moore (5-4) S: Bob McClure (8) | Seventh | 29 out |
| Thursday, August 17 |
| » Lost to Brewers (67-52), 6-0 | County Stadium (0-8) | 46-74 | Lost 4 |
| » W: Bill Travers (8-7) L: Jim Clancy (9-10) | Seventh | 30 out |
| Friday, August 18 |
| » Lost to Twins (55-67), 4-3 | Metropolitan Stadium (1-2) | 46-75 | Lost 5 |
| » W: Jeff Holly (1-1) L: Tom Murphy (4-9) | Seventh | 31 out |
| Saturday, August 19 |
| » Lost to Twins (56-67), 5-0 | Metropolitan Stadium (1-3) | 46-76 | Lost 6 |
| » W: Gary Serum (7-5) L: Jerry Garvin (3-12) | Seventh | 31 out |
| Sunday, August 20 |
| » Defeated Twins (56-68), 6-2 | Metropolitan Stadium (2-3) | 47-76 | |
| » W: Don Kirkwood (2-1) L: Stan Perzanowski (2-5) S: Tom Murphy (7) | Sixth | 31 out |
| Monday, August 21 |
| » Defeated Rangers (60-62), 8-6 | Exhibition Stadium (31-31) | 48-76 | Won 2 |
| » W: Tom Murphy (5-9) L: Jim Umbarger (4-8) | Sixth | 30½ out |
| Tuesday, August 22 |
| » Defeated Rangers (60-63), 3-1 | Exhibition Stadium (32-31) | 49-76 | Won 3 |
| » W: Jim Clancy (10-10) L: Doc Medich (7-7) S: Victor Cruz (9) | Seventh | 29½ out |
| Wednesday, August 23 |
| » Defeated Tigers (69-55), 4-3 | Tiger Stadium (3-3) | 50-76 | Won 4 |
| » W: Victor Cruz (4-1) L: Dave Rozema (6-8) | Seventh | 28 out |
| » Defeated Tigers (69-56), 5-4 | Tiger Stadium (4-3) | 51-76 | Won 5 |
| » W: Jerry Garvin (4-12) L: Bob Sykes (6-6) S: Mike Willis (6) | Seventh | 28 out |
| Thursday, August 24 |
| » Lost to Tigers (70-56), 5-2 | Tiger Stadium (4-4) | 51-77 | |
| » W: Milt Wilcox (11-8) L: Balor Moore (5-5) | Seventh | 28½ out |
| Friday, August 25 |
| » Defeated Twins (56-73), 7-3 | Exhibition Stadium (33-31) | 52-77 | |
| » W: Don Kirkwood (3-1) L: Gary Serum (7-6) S: Mike Willis (7) | Seventh | 28½ out |
| Saturday, August 26 |
| » Defeated Twins (56-74), 4-3 | Exhibition Stadium (34-31) | 53-77 | Won 2 |
| » W: Victor Cruz (5-1) L: Geoff Zahn (9-13) | Seventh | 28½ out |
| Sunday, August 27 |
| » Lost to Twins (57-74), 3-2 | Exhibition Stadium (34-32) | 53-78 | |
| » W: Mike Marshall (7-11) L: Mike Willis (2-6) | Seventh | 29½ out |
| Monday, August 28 |
| » Lost to Rangers (65-64), 11-3 | Arlington Stadium (2-3) | 53-79 | Lost 2 |
| » W: Steve Comer (7-3) L: Tom Underwood (6-11) S: Len Barker (4) | Seventh | 30½ out |
| Tuesday, August 29 |
| » Defeated Rangers (65-65), 4-1 | Arlington Stadium (3-3) | 54-79 | |
| » W: Balor Moore (6-5) L: Jon Matlack (12-11) | Seventh | 30½ out |
| Wednesday, August 30 |
| » Lost to Red Sox (84-47), 2-1 | Fenway Park (1-3) | 54-80 | |
| » W: Dennis Eckersley (16-5) L: Don Kirkwood (3-2) | Seventh | 30½ out |
| » Defeated Red Sox (84-48), 7-6 | Fenway Park (2-3) | 55-80 | |
| » W: Victor Cruz (6-1) L: Bob Stanley (12-2) | Seventh | 30½ out |
| Friday, September 1 |
| » Lost to Angels (71-63), 6-4 | Exhibition Stadium (34-33) | 55-81 | |
| » W: Paul Hartzell (6-8) L: Jesse Jefferson (7-11) S: Dave LaRoche (19) | Seventh | 30½ out |
| Saturday, September 2 |
| » Lost to Angels (72-63), 2-0 | Exhibition Stadium (34-34) | 55-82 | Lost 2 |
| » W: Frank Tanana (17-9) L: Jim Clancy (10-11) | Seventh | 30½ out |
| Sunday, September 3 |
| » Lost to Angels (73-63), 3-1 | Exhibition Stadium (34-35) | 55-83 | Lost 3 |
| » W: Chris Knapp (14-7) L: Tom Underwood (6-12) | Seventh | 31½ out |
| Monday, September 4 |
| » Lost to Indians (59-78), 5-4 | Exhibition Stadium (34-36) | 55-84 | Lost 4 |
| » W: Mike Paxton (10-8) L: Balor Moore (6-6) | Seventh | 31½ out |
| Tuesday, September 5 |
| » Lost to Indians (60-78), 6-2 | Exhibition Stadium (34-37) | 55-85 | Lost 5 |
| » W: Rick Waits (11-13) L: Don Kirkwood (3-3) | Seventh | 31½ out |
| Wednesday, September 6 |
| » Lost to Brewers (80-59), 7-0 | Exhibition Stadium (34-38) | 55-86 | Lost 6 |
| » W: Lary Sorensen (16-10) L: Jesse Jefferson (7-12) | Seventh | 32½ out |
| Thursday, September 7 |
| » Defeated Brewers (80-60), 5-4 | Exhibition Stadium (35-38) | 56-86 | |
| » W: Victor Cruz (7-1) L: Bob McClure (2-5) | Seventh | 31½ out |
| Friday, September 8 |
| » Lost to Orioles (79-62), 5-4 | Exhibition Stadium (35-39) | 56-87 | |
| » W: Nelson Briles (4-4) L: Tom Underwood (6-13) S: Don Stanhouse (22) | Seventh | 31½ out |
| Saturday, September 9 |
| » Lost to Orioles (80-62), 4-0 | Exhibition Stadium (35-40) | 56-88 | Lost 2 |
| » W: Scott McGregor (14-12) L: Balor Moore (6-7) | Seventh | 31½ out |
| Monday, September 11 |
| » Lost to Indians (62-80), 6-4 | Cleveland Stadium (1-4) | 56-89 | Lost 3 |
| » W: Rick Waits (12-13) L: Jesse Jefferson (7-13) | Seventh | 31½ out |
| » Defeated Indians (62-81), 7-1 | Cleveland Stadium (2-4) | 57-89 | |
| » W: Don Kirkwood (4-3) L: Rick Wise (9-19) | Seventh | 31½ out |
| Friday, September 15 |
| » Lost to Orioles (82-65), 8-3 | Memorial Stadium (1-4) | 57-90 | |
| » W: Jim Palmer (19-12) L: Victor Cruz (7-2) | Seventh | 32½ out |
| Saturday, September 16 |
| » Lost to Orioles (83-65), 11-1 | Memorial Stadium (1-5) | 57-91 | Lost 2 |
| » W: Dennis Martinez (14-11) L: Jesse Jefferson (7-14) | Seventh | 33½ out |
| Sunday, September 17 |
| » Lost to Orioles (84-65), 5-0 | Memorial Stadium (1-6) | 57-92 | Lost 3 |
| » W: Mike Flanagan (18-13) L: Don Kirkwood (4-4) | Seventh | 33½ out |
| Wednesday, September 20 |
| » Defeated Yankees (91-60), 8-1 | Exhibition Stadium (36-40) | 58-92 | |
| » W: Mike Willis (3-6) L: Ron Guidry (22-3) | Seventh | 33½ out |
| » Lost to Yankees (92-60), 3-2 | Exhibition Stadium (36-41) | 58-93 | |
| » W: Rich Gossage (10-10) L: Victor Cruz (7-3) | Seventh | 33½ out |
| Thursday, September 21 |
| » Lost to Yankees (93-60), 7-1 | Exhibition Stadium (36-42) | 58-94 | Lost 2 |
| » W: Catfish Hunter (11-5) L: Balor Moore (6-8) S: Rich Gossage (24) | Seventh | 34½ out |
| Friday, September 22 |
| » Defeated Red Sox (91-63), 5-4 | Exhibition Stadium (37-42) | 59-94 | |
| » W: Tom Murphy (6-9) L: Andy Hassler (3-5) | Seventh | 33½ out |
| Saturday, September 23 |
| » Lost to Red Sox (92-63), 3-1 | Exhibition Stadium (37-43) | 59-95 | |
| » W: Luis Tiant (11-8) L: Jesse Jefferson (7-15) | Seventh | 33½ out |
| Sunday, September 24 |
| » Lost to Red Sox (93-63), 7-6 | Exhibition Stadium (37-44) | 59-96 | Lost 2 |
| » W: Dick Drago (4-4) L: Tom Buskey (0-1) | Seventh | 34½ out |
| Tuesday, September 26 |
| » Lost to Yankees (95-62), 4-1 | Yankee Stadium (1-4) | 59-97 | Lost 3 |
| » W: Ed Figueroa (19-9) L: Tom Underwood (6-14) S: Rich Gossage (25) | Seventh | 35½ out |
| Wednesday, September 27 |
| » Lost to Yankees (96-62), 5-1 | Yankee Stadium (1-5) | 59-98 | Lost 4 |
| » W: Catfish Hunter (12-5) L: Mike Willis (3-7) | Seventh | 36½ out |
| Thursday, September 28 |
| » Lost to Yankees (97-62), 3-1 | Yankee Stadium (1-6) | 59-99 | Lost 5 |
| » W: Ron Guidry (24-3) L: Balor Moore (6-9) | Seventh | 37½ out |
| Friday, September 29 |
| » Lost to Red Sox (97-63), 11-0 | Fenway Park (2-4) | 59-100 | Lost 6 |
| » W: Bob Stanley (15-2) L: Jim Clancy (10-12) | Seventh | 38½ out |
| Saturday, September 30 |
| » Lost to Red Sox (98-63), 5-1 | Fenway Park (2-5) | 59-101 | Lost 7 |
| » W: Dennis Eckersley (20-8) L: Jesse Jefferson (7-16) | Seventh | 39½ out |
| Sunday, October 1 |
| » Lost to Red Sox (99-63), 5-0 | Fenway Park (2-6) | 59-102 | Lost 8 |
| » W: Luis Tiant (13-8) L: Don Kirkwood (4-5) | Sixth | 39½ out |
| Sunday, November 5 |
| Future Blue Jay Corey Thurman is born in Augusta, GA. |
| Friday, December 8 |
| Future Blue Jay Vernon Wells is born in Shreveport, LA. |
| Tuesday, December 19 |
| Future Blue Jay Vinnie Chulk is born in Miami, FL. |
Game information provided by Retrosheet (www.retrosheet.org) |