| Sunday, February 12 |
| Future Astro Tim Redding is born in Rochester, NY. |
| Saturday, March 18 |
| Future Astro Mike Gallo is born in Long Beach, CA. |
| Wednesday, March 22 |
| Future Astro Jeremy Griffiths is born in Fairview, OH. |
| Wednesday, March 29 |
| Future Astro Eric Bruntlett is born in Lafayette, IN. |
| Wednesday, April 5 |
| » Major-league debuts: Hosken Powell (Twins) |
| Thursday, April 6 |
| » Lost to Reds (1-0), 11-9 | Riverfront Stadium (0-1) | 0-1 | |
| » W: Pedro Borbon (1-0) L: J.R. Richard (0-1) S: Dave Tomlin (1) | Third | 1 out |
| Friday, April 7 |
| » Lost to Reds (2-0), 5-4 | Riverfront Stadium (0-2) | 0-2 | Lost 2 |
| » W: Bill Bonham (1-0) L: Joe Niekro (0-1) S: Pedro Borbon (1) | Fourth | 2 out |
| Saturday, April 8 |
| » Lost to Reds (3-0), 2-1 | Riverfront Stadium (0-3) | 0-3 | Lost 3 |
| » W: Fred Norman (1-0) L: Joaquin Andujar (0-1) S: Doug Bair (1) | Fifth | 3 out |
| Sunday, April 9 |
| » Lost to Reds (4-0), 9-3 | Riverfront Stadium (0-4) | 0-4 | Lost 4 |
| » W: Tom Hume (1-0) L: Mark Lemongello (0-1) | Sixth | 4 out |
| Monday, April 10 |
| » Lost to Dodgers (4-0), 5-2 | Astrodome (0-1) | 0-5 | Lost 5 |
| » W: Doug Rau (1-0) L: Floyd Bannister (0-1) S: Terry Forster (2) | Fourth | 4½ out |
| Tuesday, April 11 |
| » Defeated Dodgers (4-1), 1-0 | Astrodome (1-1) | 1-5 | |
| » W: J.R. Richard (1-1) L: Burt Hooton (0-1) | Fifth | 3½ out |
| Wednesday, April 12 |
| » Defeated Dodgers (4-2), 11-10 | Astrodome (2-1) | 2-5 | Won 2 |
| » W: Joe Sambito (1-0) L: Bobby Castillo (0-1) | Fifth | 3½ out |
| Friday, April 14 |
| » Lost to Reds (7-1), 8-4 | Astrodome (2-2) | 2-6 | |
| » W: Tom Hume (2-0) L: Joaquin Andujar (0-2) S: Dale Murray (1) | Fifth | 5 out |
| Saturday, April 15 |
| » Defeated Reds (7-2), 6-1 | Astrodome (3-2) | 3-6 | |
| » W: Mark Lemongello (1-1) L: Doug Capilla (0-1) | Fifth | 4 out |
| Sunday, April 16 |
| » Defeated Reds (7-3), 4-3 | Astrodome (4-2) | 4-6 | Won 2 |
| » W: Tom Dixon (1-0) L: Manny Sarmiento (1-1) | Fourth | 3 out |
| Tuesday, April 18 |
| » Defeated Padres (2-6), 5-1 | San Diego/Jack Murphy Stadium (1-0) | 5-6 | Won 3 |
| » W: Joe Niekro (1-1) L: Bob Shirley (0-3) | Third | 3½ out |
| Wednesday, April 19 |
| » Defeated Padres (2-7), 2-1 | San Diego/Jack Murphy Stadium (2-0) | 6-6 | Won 4 |
| » W: Joaquin Andujar (1-2) L: Dave Freisleben (0-1) S: Joe Sambito (1) | Fourth | 2½ out |
| Thursday, April 20 |
| » Lost to Dodgers (8-4), 5-1 | Dodger Stadium (0-1) | 6-7 | |
| » W: Doug Rau (2-0) L: Mark Lemongello (1-2) | Fourth | 3 out |
| Friday, April 21 |
| » Defeated Dodgers (8-5), 8-6 | Dodger Stadium (1-1) | 7-7 | |
| » W: Ken Forsch (1-0) L: Bobby Castillo (0-2) | Fourth | 2 out |
| Saturday, April 22 |
| » Lost to Dodgers (9-5), 5-1 | Dodger Stadium (1-2) | 7-8 | |
| » W: Burt Hooton (1-2) L: Floyd Bannister (0-2) | Fourth | 3 out |
| Sunday, April 23 |
| » Lost to Dodgers (10-5), 7-3 | Dodger Stadium (1-3) | 7-9 | Lost 2 |
| » W: Don Sutton (2-1) L: Joe Niekro (1-2) | Fifth | 4 out |
| Monday, April 24 |
| » Defeated Padres (6-8), 4-3 | Astrodome (5-2) | 8-9 | |
| » W: Joe Sambito (2-0) L: Rollie Fingers (1-3) | Fourth | 3½ out |
| Tuesday, April 25 |
| » Defeated Padres (6-9), 4-3 | Astrodome (6-2) | 9-9 | Won 2 |
| » W: Mark Lemongello (2-2) L: Randy Jones (1-1) | Third | 3 out |
| Wednesday, April 26 |
| » Lost to Padres (7-9), 2-1 | Astrodome (6-3) | 9-10 | |
| » W: Gaylord Perry (2-0) L: J.R. Richard (1-2) S: Rollie Fingers (4) | Third | 4 out |
| Friday, April 28 |
| » Lost to Expos (10-7), 6-3 | Astrodome (6-4) | 9-11 | Lost 2 |
| » W: Ross Grimsley (4-0) L: Joe Niekro (1-3) | Fourth | 5 out |
| Saturday, April 29 |
| » Defeated Expos (10-8), 3-1 | Astrodome (7-4) | 10-11 | |
| » W: Joaquin Andujar (2-2) L: Steve Rogers (2-3) | Third | 4 out |
| Sunday, April 30 |
| » Lost to Expos (11-8), 2-1 | Astrodome (7-5) | 10-12 | |
| » W: Rudy May (2-1) L: Mark Lemongello (2-3) S: Stan Bahnsen (4) | Fourth | 4 out |
| Wednesday, May 3 |
| » Lost to Expos (12-8), 10-3 | Stade Olympique (0-1) | 10-13 | Lost 2 |
| » W: Ross Grimsley (5-0) L: J.R. Richard (1-3) | Fourth | 4½ out |
| Friday, May 5 |
| » Lost to Braves (9-15), 5-2 | Atlanta-Fulton County Stadium (0-1) | 10-14 | Lost 3 |
| » W: Tommy Boggs (1-3) L: Joe Niekro (1-4) S: Eddie Solomon (2) | Fifth | 6 out |
| Saturday, May 6 |
| » Lost to Braves (10-15), 2-1 | Atlanta-Fulton County Stadium (0-2) | 10-15 | Lost 4 |
| » W: Dave Campbell (1-1) L: Ken Forsch (1-1) | Fifth | 6 out |
| Tuesday, May 9 |
| » Defeated Phillies (14-9), 5-1 | Veteran's Stadium (1-0) | 11-15 | |
| » W: J.R. Richard (2-3) L: Larry Christenson (2-3) | Fourth | 5½ out |
| Wednesday, May 10 |
| » Lost to Phillies (15-9), 3-1 | Veteran's Stadium (1-1) | 11-16 | |
| » W: Jim Lonborg (4-2) L: Mark Lemongello (2-4) | Fourth | 5½ out |
| Friday, May 12 |
| » Defeated Mets (14-19), 5-4 | Shea Stadium (1-0) | 12-16 | |
| » W: Tom Dixon (2-0) L: Skip Lockwood (1-3) | Fourth | 4½ out |
| Saturday, May 13 |
| » Defeated Mets (14-20), 7-4 | Shea Stadium (2-0) | 13-16 | Won 2 |
| » W: Joe Niekro (2-4) L: Mike Bruhert (1-3) S: Joe Sambito (2) | Fourth | 4½ out |
| Monday, May 15 |
| » Defeated Phillies (17-12), 5-0 | Astrodome (8-5) | 14-16 | Won 3 |
| » W: J.R. Richard (3-3) L: Jim Lonborg (4-3) | Third | 5 out |
| Tuesday, May 16 |
| » Defeated Phillies (17-13), 6-1 | Astrodome (9-5) | 15-16 | Won 4 |
| » W: Mark Lemongello (3-4) L: Steve Carlton (4-4) | Third | 5 out |
| Wednesday, May 17 |
| » Defeated Phillies (17-14), 2-1 | Astrodome (10-5) | 16-16 | Won 5 |
| » W: Joaquin Andujar (3-2) L: Randy Lerch (3-3) S: Tom Dixon (1) | Fourth | 5 out |
| Thursday, May 18 |
| » Lost to Phillies (18-14), 8-5 | Astrodome (10-6) | 16-17 | |
| » W: Gene Garber (2-0) L: Joe Sambito (2-1) | Fourth | 5½ out |
| Friday, May 19 |
| » Defeated Braves (13-21), 6-0 | Astrodome (11-6) | 17-17 | |
| » W: Floyd Bannister (1-2) L: Dick Ruthven (2-4) | Fourth | 5½ out |
| Saturday, May 20 |
| » Defeated Braves (13-22), 13-0 | Astrodome (12-6) | 18-17 | Won 2 |
| » W: J.R. Richard (4-3) L: Tommy Boggs (1-5) | Fourth | 4½ out |
| Sunday, May 21 |
| » Lost to Braves (14-22), 6-4 | Astrodome (12-7) | 18-18 | |
| » W: Phil Niekro (4-6) L: Mark Lemongello (3-5) S: Adrian Devine (2) | Fourth | 4½ out |
| Tuesday, May 23 |
| » Lost to Giants (24-14), 3-2 | Candlestick Park (0-1) | 18-19 | Lost 2 |
| » W: Randy Moffitt (3-1) L: Joe Sambito (2-2) | Fourth | 5½ out |
| Wednesday, May 24 |
| » Lost to Giants (25-14), 2-0 | Candlestick Park (0-2) | 18-20 | Lost 3 |
| » W: John Montefusco (4-2) L: Ken Forsch (1-2) S: Gary Lavelle (7) | Fourth | 6½ out |
| Thursday, May 25 |
| » Lost to Giants (26-14), 9-1 | Candlestick Park (0-3) | 18-21 | Lost 4 |
| » W: Ed Halicki (1-0) L: J.R. Richard (4-4) | Fifth | 7½ out |
| Friday, May 26 |
| » Defeated Mets (20-24), 5-4 | Astrodome (13-7) | 19-21 | |
| » W: Mark Lemongello (4-5) L: Jerry Koosman (2-5) S: Ken Forsch (1) | Fourth | 7½ out |
| Saturday, May 27 |
| » Lost to Mets (21-24), 9-7 | Astrodome (13-8) | 19-22 | |
| » W: Butch Metzger (1-1) L: Joe Sambito (2-3) S: Dale Murray (3) | Fourth | 7½ out |
| Sunday, May 28 |
| » Lost to Mets (22-24), 4-1 | Astrodome (13-9) | 19-23 | Lost 2 |
| » W: Nino Espinosa (5-2) L: Tom Dixon (2-1) | Fifth | 8½ out |
| Monday, May 29 |
| » Lost to Giants (29-15), 8-1 | Astrodome (13-10) | 19-24 | Lost 3 |
| » W: Ed Halicki (2-0) L: Floyd Bannister (1-3) | Fifth | 9½ out |
| Tuesday, May 30 |
| » Lost to Giants (30-15), 1-0 | Astrodome (13-11) | 19-25 | Lost 4 |
| » W: Bob Knepper (7-2) L: J.R. Richard (4-5) | Fifth | 10½ out |
| Wednesday, May 31 |
| » Defeated Giants (30-16), 1-0 | Astrodome (14-11) | 20-25 | |
| » W: Mark Lemongello (5-5) L: Vida Blue (6-3) | Fifth | 9½ out |
| Friday, June 2 |
| » Defeated Cardinals (18-33), 2-1 | Astrodome (15-11) | 21-25 | Won 2 |
| » W: Joe Sambito (3-3) L: John Denny (4-4) | Fifth | 9½ out |
| Saturday, June 3 |
| » Defeated Cardinals (18-34), 5-2 | Astrodome (16-11) | 22-25 | Won 3 |
| » W: Floyd Bannister (2-3) L: Pete Falcone (0-4) S: Ken Forsch (2) | Fourth | 9 out |
| » Lost to Cardinals (19-34), 2-1 | Astrodome (16-12) | 22-26 | |
| » W: Pete Vuckovich (2-4) L: Tom Dixon (2-2) | Fourth | 9 out |
| Sunday, June 4 |
| » Lost to Cardinals (20-34), 4-2 | Astrodome (16-13) | 22-27 | Lost 2 |
| » W: Silvio Martinez (2-0) L: J.R. Richard (4-6) S: Buddy Schultz (2) | Fifth | 10 out |
| Monday, June 5 |
| » Lost to Cubs (28-20), 2-1 | Wrigley Field (0-1) | 22-28 | Lost 3 |
| » W: Willie Hernandez (5-1) L: Mark Lemongello (5-6) | Fifth | 10 out |
| Tuesday, June 6 |
| » Lost to Cubs (29-20), 9-4 | Wrigley Field (0-2) | 22-29 | Lost 4 |
| » W: Dave Roberts (3-0) L: Joaquin Andujar (3-3) | Fifth | 10 out |
| Friday, June 9 |
| » Defeated Cardinals (22-37), 11-7 | Busch Stadium II (1-0) | 23-29 | |
| » W: J.R. Richard (5-6) L: George Frazier (0-1) S: Ken Forsch (3) | Fourth | 8½ out |
| Saturday, June 10 |
| » Defeated Cardinals (22-38), 12-5 | Busch Stadium II (2-0) | 24-29 | Won 2 |
| » W: Mark Lemongello (6-6) L: Bob Forsch (7-5) | Fourth | 8½ out |
| Sunday, June 11 |
| » Lost to Cardinals (23-38), 5-3 | Busch Stadium II (2-1) | 24-30 | |
| » W: John Denny (6-4) L: Joaquin Andujar (3-4) | Fourth | 9½ out |
| Monday, June 12 |
| » Defeated Pirates (26-30), 6-5 | Astrodome (17-13) | 25-30 | |
| » W: Rick Williams (1-0) L: Ed Whitson (0-1) S: Joe Sambito (3) | Fourth | 9½ out |
| » Major-league debuts: Rick Williams (Astros) |
| Tuesday, June 13 |
| » Defeated Pirates (26-31), 2-1 | Astrodome (18-13) | 26-30 | Won 2 |
| » W: Ken Forsch (2-2) L: Jim Bibby (5-3) S: Joe Sambito (4) | Fourth | 9½ out |
| Wednesday, June 14 |
| » Lost to Pirates (27-31), 6-4 | Astrodome (18-14) | 26-31 | |
| » W: Ed Whitson (1-1) L: J.R. Richard (5-7) S: Kent Tekulve (7) | Fourth | 10½ out |
| Friday, June 16 |
| » Lost to Cubs (34-24), 7-6 | Astrodome (18-15) | 26-32 | Lost 2 |
| » W: Paul Reuschel (2-0) L: Rick Williams (1-1) | Fourth | 12 out |
| Saturday, June 17 |
| » Defeated Cubs (34-25), 5-4 | Astrodome (19-15) | 27-32 | |
| » W: Joe Niekro (3-4) L: Willie Hernandez (5-2) | Fourth | 11 out |
| Sunday, June 18 |
| » Defeated Cubs (34-26), 3-1 | Astrodome (20-15) | 28-32 | Won 2 |
| » W: Tom Dixon (3-2) L: Dennis Lamp (2-7) S: Joe Sambito (5) | Fourth | 11½ out |
| Tuesday, June 20 |
| » Defeated Dodgers (36-29), 5-3 | Dodger Stadium (2-3) | 29-32 | Won 3 |
| » W: J.R. Richard (6-7) L: Tommy John (8-5) S: Bo McLaughlin (1) | Fourth | 10½ out |
| » Major-league debuts: Bob Welch (Dodgers) |
| Wednesday, June 21 |
| » Lost to Dodgers (37-29), 5-4 | Dodger Stadium (2-4) | 29-33 | |
| » W: Bob Welch (1-0) L: Joe Sambito (3-4) | Fourth | 11½ out |
| Thursday, June 22 |
| » Defeated Dodgers (37-30), 4-3 | Dodger Stadium (3-4) | 30-33 | |
| » W: Joe Niekro (4-4) L: Doug Rau (7-3) | Fourth | 10½ out |
| Friday, June 23 |
| » Lost to Padres (31-37), 3-0 | San Diego/Jack Murphy Stadium (2-1) | 30-34 | |
| » W: Gaylord Perry (8-2) L: Tom Dixon (3-3) | Fourth | 11½ out |
| Saturday, June 24 |
| » Lost to Padres (32-37), 6-5 | San Diego/Jack Murphy Stadium (2-2) | 30-35 | Lost 2 |
| » W: Rollie Fingers (3-7) L: Ken Forsch (2-3) | Fifth | 12½ out |
| Sunday, June 25 |
| » Lost to Padres (33-37), 6-1 | San Diego/Jack Murphy Stadium (2-3) | 30-36 | Lost 3 |
| » W: Bob Shirley (4-9) L: J.R. Richard (6-8) | Fifth | 13½ out |
| » Lost to Padres (34-37), 7-4 | San Diego/Jack Murphy Stadium (2-4) | 30-37 | Lost 4 |
| » W: Eric Rasmussen (4-7) L: Bo McLaughlin (0-1) S: John D'Acquisto (4) | Fifth | 13½ out |
| Monday, June 26 |
| » Lost to Reds (44-28), 4-3 | Astrodome (20-16) | 30-38 | Lost 5 |
| » W: Tom Seaver (9-5) L: Mark Lemongello (6-7) S: Dave Tomlin (3) | Fifth | 13½ out |
| Tuesday, June 27 |
| » Defeated Reds (44-29), 7-4 | Astrodome (21-16) | 31-38 | |
| » W: Joe Niekro (5-4) L: Bill Bonham (8-2) S: Joe Sambito (6) | Fifth | 13½ out |
| Wednesday, June 28 |
| » Defeated Reds (44-30), 3-0 | Astrodome (22-16) | 32-38 | Won 2 |
| » W: Tom Dixon (4-3) L: Fred Norman (8-5) | Fifth | 13 out |
| Thursday, June 29 |
| » Defeated Reds (44-31), 5-0 | Astrodome (23-16) | 33-38 | Won 3 |
| » W: Floyd Bannister (3-3) L: Tom Hume (2-8) | Fifth | 12½ out |
| Friday, June 30 |
| » Lost to Padres (37-39), 5-2 | Astrodome (23-17) | 33-39 | |
| » W: Bob Shirley (5-9) L: J.R. Richard (6-9) S: Rollie Fingers (17) | Fifth | 12 out |
| Saturday, July 1 |
| » Defeated Padres (37-40), 9-2 | Astrodome (24-17) | 34-39 | |
| » W: Mark Lemongello (7-7) L: Bob Owchinko (5-7) | Fifth | 12½ out |
| » Lost to Padres (38-40), 9-3 | Astrodome (24-18) | 34-40 | |
| » W: Mark Wiley (1-0) L: Joe Niekro (5-5) S: John D'Acquisto (6) | Fifth | 12½ out |
| Sunday, July 2 |
| » Lost to Padres (39-40), 6-2 | Astrodome (24-19) | 34-41 | Lost 2 |
| » W: Gaylord Perry (9-3) L: Tom Dixon (4-4) S: Rollie Fingers (18) | Fifth | 12½ out |
| Monday, July 3 |
| » Lost to Reds (46-34), 8-7 | Riverfront Stadium (0-5) | 34-42 | Lost 3 |
| » W: Doug Bair (3-3) L: Joe Sambito (3-5) | Fifth | 12½ out |
| Tuesday, July 4 |
| » Defeated Reds (46-35), 3-1 | Riverfront Stadium (1-5) | 35-42 | |
| » W: J.R. Richard (7-9) L: Tom Hume (2-9) | Fifth | 11½ out |
| Wednesday, July 5 |
| » Lost to Reds (47-35), 2-1 | Riverfront Stadium (1-6) | 35-43 | |
| » W: Paul Moskau (1-2) L: Joe Niekro (5-6) S: Doug Bair (13) | Fifth | 12½ out |
| Friday, July 7 |
| » Lost to Dodgers (48-35), 7-4 | Astrodome (24-20) | 35-44 | Lost 2 |
| » W: Doug Rau (9-4) L: Mark Lemongello (7-8) S: Charlie Hough (4) | Fifth | 13½ out |
| Saturday, July 8 |
| » Lost to Dodgers (49-35), 7-1 | Astrodome (24-21) | 35-45 | Lost 3 |
| » W: Burt Hooton (8-7) L: Floyd Bannister (3-4) | Sixth | 15 out |
| » Lost to Dodgers (50-35), 7-5 | Astrodome (24-22) | 35-46 | Lost 4 |
| » W: Tommy John (10-6) L: Tom Dixon (4-5) | Sixth | 15 out |
| Sunday, July 9 |
| » Defeated Dodgers (50-36), 5-1 | Astrodome (25-22) | 36-46 | |
| » W: J.R. Richard (8-9) L: Don Sutton (9-7) | Sixth | 14 out |
| Thursday, July 13 |
| » Lost to Expos (42-45), 6-0 | Stade Olympique (0-2) | 36-47 | |
| » W: Ross Grimsley (12-6) L: Joe Niekro (5-7) | Sixth | 15 out |
| Friday, July 14 |
| » Defeated Expos (42-46), 4-3 | Stade Olympique (1-2) | 37-47 | |
| » W: Ken Forsch (3-3) L: Stan Bahnsen (0-3) | Fourth | 13½ out |
| » Defeated Expos (42-47), 5-4 | Stade Olympique (2-2) | 38-47 | Won 2 |
| » W: Ken Forsch (4-3) L: Gerry Pirtle (0-1) S: Bo McLaughlin (2) | Fourth | 13½ out |
| Saturday, July 15 |
| » Lost to Expos (43-47), 8-0 | Stade Olympique (2-3) | 38-48 | |
| » W: Woodie Fryman (4-7) L: Tom Dixon (4-6) | Fifth | 14½ out |
| Sunday, July 16 |
| » Lost to Expos (44-47), 6-1 | Stade Olympique (2-4) | 38-49 | Lost 2 |
| » W: Dan Schatzeder (3-1) L: Floyd Bannister (3-5) | Sixth | 15 out |
| Monday, July 17 |
| » Defeated Phillies (48-37), 2-1 | Astrodome (26-22) | 39-49 | |
| » W: Joe Niekro (6-7) L: Rawly Eastwick (4-2) | Sixth | 15 out |
| Tuesday, July 18 |
| » Defeated Phillies (48-38), 9-1 | Astrodome (27-22) | 40-49 | Won 2 |
| » W: J.R. Richard (9-9) L: Jim Lonborg (7-7) | Sixth | 14 out |
| Wednesday, July 19 |
| » Defeated Mets (38-56), 8-3 | Shea Stadium (3-0) | 41-49 | Won 3 |
| » W: Tom Dixon (5-6) L: Pat Zachry (10-6) S: Joe Sambito (7) | Sixth | 14 out |
| » Lost to Mets (39-56), 2-1 | Shea Stadium (3-1) | 41-50 | |
| » W: Craig Swan (2-5) L: Mark Lemongello (7-9) | Sixth | 14 out |
| » Major-league debuts: Bruce Bochy (Astros) |
| Thursday, July 20 |
| » Lost to Mets (40-56), 7-4 | Shea Stadium (3-2) | 41-51 | Lost 2 |
| » W: Mike Bruhert (2-5) L: Floyd Bannister (3-6) S: Skip Lockwood (12) | Sixth | 15½ out |
| » Lost to Mets (41-56), 5-4 | Shea Stadium (3-3) | 41-52 | Lost 3 |
| » W: Dale Murray (5-4) L: Joe Sambito (3-6) | Sixth | 15½ out |
| Friday, July 21 |
| » Lost to Phillies (50-39), 6-1 | Veteran's Stadium (1-2) | 41-53 | Lost 4 |
| » W: Dick Ruthven (7-8) L: Joe Niekro (6-8) | Sixth | 16 out |
| » Lost to Phillies (51-39), 8-2 | Veteran's Stadium (1-3) | 41-54 | Lost 5 |
| » W: Larry Christenson (7-8) L: Rick Williams (1-2) | Sixth | 16 out |
| Saturday, July 22 |
| » Lost to Phillies (52-39), 3-2 | Veteran's Stadium (1-4) | 41-55 | Lost 6 |
| » W: Ron Reed (1-0) L: Ken Forsch (4-4) | Sixth | 17 out |
| Sunday, July 23 |
| » Lost to Phillies (53-39), 13-2 | Veteran's Stadium (1-5) | 41-56 | Lost 7 |
| » W: Steve Carlton (9-9) L: Tom Dixon (5-7) | Sixth | 18 out |
| Monday, July 24 |
| » Defeated Expos (47-53), 6-5 | Astrodome (28-22) | 42-56 | |
| » W: Ken Forsch (5-4) L: Darold Knowles (2-3) | Sixth | 17½ out |
| Tuesday, July 25 |
| » Defeated Expos (47-54), 3-2 | Astrodome (29-22) | 43-56 | Won 2 |
| » W: Ken Forsch (6-4) L: Wayne Twitchell (3-10) | Sixth | 17½ out |
| Wednesday, July 26 |
| » Defeated Expos (47-55), 5-0 | Astrodome (30-22) | 44-56 | Won 3 |
| » W: Joe Niekro (7-8) L: Ross Grimsley (12-8) | Sixth | 16½ out |
| Thursday, July 27 |
| » Defeated Mets (45-59), 8-3 | Astrodome (31-22) | 45-56 | Won 4 |
| » W: J.R. Richard (10-9) L: Tom Hausman (2-1) | Sixth | 16 out |
| Friday, July 28 |
| » Defeated Mets (45-60), 4-3 | Astrodome (32-22) | 46-56 | Won 5 |
| » W: Joe Sambito (4-6) L: Skip Lockwood (7-9) | Sixth | 15 out |
| Sunday, July 30 |
| » Defeated Mets (45-61), 4-3 | Astrodome (33-22) | 47-56 | Won 6 |
| » W: Joaquin Andujar (4-4) L: Dwight Bernard (0-1) | Fifth | 15 out |
| Monday, July 31 |
| » Defeated Giants (63-43), 4-1 | Astrodome (34-22) | 48-56 | Won 7 |
| » W: Joe Niekro (8-8) L: Ed Halicki (5-5) | Fifth | 14 out |
| Tuesday, August 1 |
| » Defeated Giants (63-44), 4-2 | Astrodome (35-22) | 49-56 | Won 8 |
| » W: J.R. Richard (11-9) L: Bob Knepper (11-8) S: Joe Sambito (8) | Fifth | 13 out |
| Wednesday, August 2 |
| » Lost to Giants (64-44), 4-2 | Astrodome (35-23) | 49-57 | |
| » W: John Montefusco (8-4) L: Tom Dixon (5-8) | Fifth | 14 out |
| Friday, August 4 |
| » Lost to Braves (50-57), 7-2 | Atlanta-Fulton County Stadium (0-3) | 49-58 | Lost 2 |
| » W: Phil Niekro (13-11) L: Mark Lemongello (7-10) | Sixth | 15½ out |
| Saturday, August 5 |
| » Defeated Braves (50-58), 5-3 | Atlanta-Fulton County Stadium (1-3) | 50-58 | |
| » W: Joe Niekro (9-8) L: Preston Hanna (7-10) S: Ken Forsch (4) | Fifth | 14 out |
| » Defeated Braves (50-59), 7-0 | Atlanta-Fulton County Stadium (2-3) | 51-58 | Won 2 |
| » W: Vern Ruhle (1-0) L: Tommy Boggs (2-7) | Fifth | 14 out |
| Sunday, August 6 |
| » Lost to Braves (51-59), 3-2 | Atlanta-Fulton County Stadium (2-4) | 51-59 | |
| » W: Larry McWilliams (4-0) L: J.R. Richard (11-10) S: Gene Garber (17) | Fifth | 14 out |
| Tuesday, August 8 |
| » Lost to Giants (67-46), 3-2 | Candlestick Park (0-4) | 51-60 | Lost 2 |
| » W: John Montefusco (9-4) L: Tom Dixon (5-9) S: Randy Moffitt (10) | Sixth | 15 out |
| Wednesday, August 9 |
| » Defeated Giants (67-47), 6-5 | Candlestick Park (1-4) | 52-60 | |
| » W: Mark Lemongello (8-10) L: Jim Barr (6-9) S: Ken Forsch (5) | Sixth | 14 out |
| Friday, August 11 |
| » Lost to Braves (54-60), 1-0 | Astrodome (35-24) | 52-61 | |
| » W: Larry McWilliams (5-0) L: Joe Niekro (9-9) S: Gene Garber (19) | Sixth | 14½ out |
| Saturday, August 12 |
| » Defeated Braves (54-61), 5-2 | Astrodome (36-24) | 53-61 | |
| » W: J.R. Richard (12-10) L: Phil Niekro (14-12) | Fifth | 13½ out |
| Sunday, August 13 |
| » Defeated Braves (54-62), 3-0 | Astrodome (37-24) | 54-61 | Won 2 |
| » W: Vern Ruhle (2-0) L: Preston Hanna (7-11) | Fifth | 13½ out |
| Monday, August 14 |
| » Defeated Cardinals (48-70), 6-0 | Busch Stadium II (3-1) | 55-61 | Won 3 |
| » W: Tom Dixon (6-9) L: Bob Forsch (9-14) | Fifth | 13 out |
| Tuesday, August 15 |
| » Lost to Cardinals (49-70), 11-5 | Busch Stadium II (3-2) | 55-62 | |
| » W: Aurelio Lopez (3-1) L: Floyd Bannister (3-7) | Fourth | 13 out |
| Wednesday, August 16 |
| » Defeated Cardinals (49-71), 4-2 | Busch Stadium II (4-2) | 56-62 | |
| » W: Joe Niekro (10-9) L: Silvio Martinez (6-6) | Fifth | 13 out |
| Thursday, August 17 |
| » Lost to Pirates (55-62), 5-1 | Three Rivers Stadium (0-1) | 56-63 | |
| » W: Don Robinson (9-5) L: J.R. Richard (12-11) | Fifth | 14½ out |
| » Lost to Pirates (56-62), 3-2 | Three Rivers Stadium (0-2) | 56-64 | Lost 2 |
| » W: Bruce Kison (4-4) L: Mark Lemongello (8-11) S: Kent Tekulve (20) | Fifth | 14½ out |
| Future Astro Chad Qualls is born in Lomita, CA. |
| Friday, August 18 |
| » Lost to Pirates (57-62), 6-3 | Three Rivers Stadium (0-3) | 56-65 | Lost 3 |
| » W: Jim Bibby (7-7) L: Vern Ruhle (2-1) S: Kent Tekulve (21) | Fifth | 15½ out |
| Saturday, August 19 |
| » Lost to Pirates (58-62), 4-2 | Three Rivers Stadium (0-4) | 56-66 | Lost 4 |
| » W: Bert Blyleven (10-8) L: Floyd Bannister (3-8) S: Kent Tekulve (22) | Fifth | 15½ out |
| Sunday, August 20 |
| » Lost to Pirates (59-62), 7-6 | Three Rivers Stadium (0-5) | 56-67 | Lost 5 |
| » W: Jim Rooker (8-8) L: Tom Dixon (6-10) S: Kent Tekulve (23) | Sixth | 17 out |
| » Lost to Pirates (60-62), 3-1 | Three Rivers Stadium (0-6) | 56-68 | Lost 6 |
| » W: Jerry Reuss (1-2) L: Joe Niekro (10-10) | Sixth | 17 out |
| Monday, August 21 |
| » Defeated Cubs (63-60), 8-3 | Astrodome (38-24) | 57-68 | |
| » W: J.R. Richard (13-11) L: Rick Reuschel (12-11) | Fifth | 16 out |
| Tuesday, August 22 |
| » Defeated Cubs (63-61), 2-1 | Astrodome (39-24) | 58-68 | Won 2 |
| » W: Mark Lemongello (9-11) L: Mike Krukow (5-2) | Fifth | 15½ out |
| Wednesday, August 23 |
| » Defeated Cubs (63-62), 3-0 | Astrodome (40-24) | 59-68 | Won 3 |
| » W: Ken Forsch (7-4) L: Dennis Lamp (5-13) S: Joe Sambito (9) | Fifth | 15½ out |
| Friday, August 25 |
| » Defeated Pirates (63-63), 7-5 | Astrodome (41-24) | 60-68 | Won 4 |
| » W: Joe Niekro (11-10) L: Jim Rooker (8-9) S: Joaquin Andujar (1) | Fifth | 16 out |
| Saturday, August 26 |
| » Defeated Pirates (63-64), 7-2 | Astrodome (42-24) | 61-68 | Won 5 |
| » W: J.R. Richard (14-11) L: Bruce Kison (4-5) | Fifth | 15 out |
| Sunday, August 27 |
| » Lost to Pirates (64-64), 8-5 | Astrodome (42-25) | 61-69 | |
| » W: Grant Jackson (6-3) L: Mark Lemongello (9-12) S: Kent Tekulve (26) | Fifth | 15 out |
| Tuesday, August 29 |
| » Defeated Cardinals (57-74), 6-3 | Astrodome (43-25) | 62-69 | |
| » W: Ken Forsch (8-4) L: Pete Vuckovich (12-10) | Fifth | 15½ out |
| Wednesday, August 30 |
| » Lost to Cardinals (58-74), 4-2 | Astrodome (43-26) | 62-70 | |
| » W: Bob Forsch (10-15) L: Joe Niekro (11-11) | Fifth | 16½ out |
| Friday, September 1 |
| » Lost to Cubs (67-65), 14-11 | Wrigley Field (0-3) | 62-71 | Lost 2 |
| » W: Willie Hernandez (8-2) L: Joe Sambito (4-7) S: Bruce Sutter (24) | Fifth | 17½ out |
| Saturday, September 2 |
| » Defeated Cubs (67-66), 8-5 | Wrigley Field (1-3) | 63-71 | |
| » W: Joaquin Andujar (5-4) L: Bruce Sutter (7-5) S: Joe Sambito (10) | Fifth | 17 out |
| Sunday, September 3 |
| » Lost to Cubs (68-66), 3-2 | Wrigley Field (1-4) | 63-72 | |
| » W: Dennis Lamp (6-13) L: Ken Forsch (8-5) S: Willie Hernandez (2) | Fifth | 17½ out |
| » Lost to Cubs (69-66), 4-2 | Wrigley Field (1-5) | 63-73 | Lost 2 |
| » W: Donnie Moore (9-6) L: Vern Ruhle (2-2) S: Willie Hernandez (3) | Fifth | 17½ out |
| » Major-league debuts: Scot Thompson (Cubs) |
| Monday, September 4 |
| » Lost to Reds (75-62), 6-3 | Astrodome (43-27) | 63-74 | Lost 3 |
| » W: Bill Bonham (10-4) L: Joe Niekro (11-12) S: Doug Bair (24) | Fifth | 18½ out |
| Tuesday, September 5 |
| » Defeated Reds (75-63), 3-2 | Astrodome (44-27) | 64-74 | |
| » W: J.R. Richard (15-11) L: Tom Seaver (12-14) | Fifth | 18 out |
| Thursday, September 7 |
| » Lost to Dodgers (84-56), 3-2 | Astrodome (44-28) | 64-75 | |
| » W: Burt Hooton (17-8) L: Mark Lemongello (9-13) S: Terry Forster (18) | Fifth | 19½ out |
| Friday, September 8 |
| » Defeated Dodgers (84-57), 5-0 | Astrodome (45-28) | 65-75 | |
| » W: Ken Forsch (9-5) L: Bob Welch (5-3) | Fifth | 18½ out |
| Saturday, September 9 |
| » Defeated Padres (73-70), 10-4 | Astrodome (46-28) | 66-75 | Won 2 |
| » W: Joe Niekro (12-12) L: Steve Mura (0-1) | Fifth | 17½ out |
| Sunday, September 10 |
| » Defeated Padres (73-71), 3-2 | Astrodome (47-28) | 67-75 | Won 3 |
| » W: J.R. Richard (16-11) L: Eric Rasmussen (14-12) | Fifth | 17½ out |
| Monday, September 11 |
| » Lost to Reds (79-64), 9-8 | Riverfront Stadium (1-7) | 67-76 | |
| » W: Dave Tomlin (8-1) L: Joaquin Andujar (5-5) | Fifth | 18½ out |
| » Major-league debuts: Harry Spilman (Reds) |
| Tuesday, September 12 |
| » Lost to Reds (80-64), 4-3 | Riverfront Stadium (1-8) | 67-77 | Lost 2 |
| » W: Doug Bair (7-5) L: Joe Sambito (4-8) | Fifth | 19½ out |
| Wednesday, September 13 |
| » Lost to Dodgers (88-58), 6-0 | Dodger Stadium (3-5) | 67-78 | Lost 3 |
| » W: Bob Welch (6-3) L: Ken Forsch (9-6) | Fifth | 20½ out |
| Thursday, September 14 |
| » Lost to Dodgers (89-58), 2-1 | Dodger Stadium (3-6) | 67-79 | Lost 4 |
| » W: Rick Rhoden (9-7) L: Joe Niekro (12-13) S: Terry Forster (20) | Fifth | 21½ out |
| Friday, September 15 |
| » Defeated Padres (76-73), 8-4 | San Diego/Jack Murphy Stadium (3-4) | 68-79 | |
| » W: J.R. Richard (17-11) L: Eric Rasmussen (14-13) | Fifth | 21½ out |
| Saturday, September 16 |
| » Lost to Padres (77-73), 2-1 | San Diego/Jack Murphy Stadium (3-5) | 68-80 | |
| » W: Gaylord Perry (19-6) L: Joe Sambito (4-9) | Fifth | 22½ out |
| Sunday, September 17 |
| » Lost to Padres (78-73), 3-1 | San Diego/Jack Murphy Stadium (3-6) | 68-81 | Lost 2 |
| » W: Randy Jones (12-14) L: Mark Lemongello (9-14) S: Rollie Fingers (34) | Fifth | 22½ out |
| Tuesday, September 19 |
| » Lost to Braves (67-84), 3-2 | Astrodome (47-29) | 68-82 | Lost 3 |
| » W: Gene Garber (5-5) L: Joaquin Andujar (5-6) | Fifth | 23 out |
| Wednesday, September 20 |
| » Lost to Braves (68-84), 3-2 | Astrodome (47-30) | 68-83 | Lost 4 |
| » W: Gene Garber (6-5) L: Joe Niekro (12-14) | Fifth | 23 out |
| Thursday, September 21 |
| » Defeated Braves (68-85), 2-0 | Astrodome (48-30) | 69-83 | |
| » W: Ken Forsch (10-6) L: Phil Niekro (19-16) | Fifth | 22½ out |
| Friday, September 22 |
| » Lost to Giants (84-70), 2-0 | Candlestick Park (1-5) | 69-84 | |
| » W: Bob Knepper (16-11) L: Vern Ruhle (2-3) | Fifth | 22½ out |
| Saturday, September 23 |
| » Lost to Giants (85-70), 3-2 | Candlestick Park (1-6) | 69-85 | Lost 2 |
| » W: Gary Lavelle (13-10) L: Joaquin Andujar (5-7) S: Randy Moffitt (12) | Fifth | 23½ out |
| Sunday, September 24 |
| » Lost to Giants (86-70), 7-0 | Candlestick Park (1-7) | 69-86 | Lost 3 |
| » W: Vida |
