| Monday, January 10 |
| Former White Sox Vic Frasier dies in Jacksonville, TX at the age of 73. |
| Friday, February 4 |
| Former White Sox Nemo Leibold dies in Detroit, MI at the age of 85. |
| Sunday, April 3 |
| Former White Sox Hank Steinbacher dies in Sacramento, CA at the age of 65. |
| Wednesday, April 6 |
| » Major-league debuts: Jose Baez (Mariners) |
| Thursday, April 7 |
| » Lost to Blue Jays (1-0), 9-5 | Exhibition Stadium (0-1) | 0-1 | |
| » W: Jerry Johnson (1-0) L: Ken Brett (0-1) S: Pete Vuckovich (1) | Fourth | 1½ out |
| » Major-league debuts: Al Woods (Blue Jays) |
| Saturday, April 9 |
| » Defeated Blue Jays (1-1), 3-2 | Exhibition Stadium (1-1) | 1-1 | |
| » W: Chris Knapp (1-0) L: Dave Lemanczyk (0-1) S: Lerrin LaGrow (1) | Third | 1 out |
| » Major-league debuts: Silvio Martinez (White Sox) |
| Sunday, April 10 |
| » Lost to Blue Jays (2-1), 3-1 | Exhibition Stadium (1-2) | 1-2 | |
| » W: Jerry Garvin (1-0) L: Steve Stone (0-1) S: Pete Vuckovich (2) | Fifth | 2 out |
| » Major-league debuts: Jerry Garvin (Blue Jays) |
| Monday, April 11 |
| » Major-league debuts: Dave Rozema (Tigers) |
| Tuesday, April 12 |
| » Defeated Red Sox (0-3), 5-2 | Comiskey Park I (1-0) | 2-2 | |
| » W: Ken Brett (1-1) L: Rick Wise (0-1) S: Dave Hamilton (1) | Fourth | 2 out |
| Wednesday, April 13 |
| » Defeated Red Sox (0-4), 7-3 | Comiskey Park I (2-0) | 3-2 | Won 2 |
| » W: Bart Johnson (1-0) L: Fergie Jenkins (0-1) S: Lerrin LaGrow (2) | Third | 1½ out |
| Friday, April 15 |
| » Defeated Blue Jays (5-3), 7-5 | Comiskey Park I (3-0) | 4-2 | Won 3 |
| » W: Francisco Barrios (1-0) L: Jerry Johnson (1-1) | Third | 2 out |
| Saturday, April 16 |
| » Defeated Blue Jays (5-4), 3-2 | Comiskey Park I (4-0) | 5-2 | Won 4 |
| » W: Steve Stone (1-1) L: Pete Vuckovich (0-1) | Third | 1 out |
| Sunday, April 17 |
| » Defeated Blue Jays (5-5), 4-2 | Comiskey Park I (5-0) | 6-2 | Won 5 |
| » W: Ken Brett (2-1) L: Bill Singer (0-2) S: Bruce Dal Canton (1) | First | -- |
| Tuesday, April 19 |
| » Lost to Angels (6-7), 11-2 | Anaheim Stadium (0-1) | 6-3 | |
| » W: Frank Tanana (3-0) L: Bart Johnson (1-1) | First | -- |
| Wednesday, April 20 |
| » Defeated Angels (6-8), 3-2 | Anaheim Stadium (1-1) | 7-3 | |
| » W: Chris Knapp (2-0) L: Nolan Ryan (2-2) S: Lerrin LaGrow (3) | First | -- |
| Thursday, April 21 |
| Future White Sox Kip Wells is born in Houston, TX. |
| Friday, April 22 |
| » Defeated Athletics (8-5), 8-2 | Oakland-Alameda County Stadium (1-0) | 8-3 | Won 2 |
| » W: Francisco Barrios (2-0) L: Vida Blue (0-2) | First | -- |
| Saturday, April 23 |
| » Lost to Athletics (9-5), 3-2 | Oakland-Alameda County Stadium (1-1) | 8-4 | |
| » W: Jim Umbarger (1-2) L: Steve Stone (1-2) S: Dave Giusti (3) | First | -- |
| Sunday, April 24 |
| » Defeated Athletics (9-6), 12-5 | Oakland-Alameda County Stadium (2-1) | 9-4 | |
| » W: Chris Knapp (3-0) L: Mike Torrez (3-1) S: Bruce Dal Canton (2) | First | -- |
| » Lost to Athletics (10-6), 11-4 | Oakland-Alameda County Stadium (2-2) | 9-5 | |
| » W: Mike Norris (1-0) L: Bart Johnson (1-2) | First | -- |
| Tuesday, April 26 |
| » Defeated Tigers (6-11), 10-7 | Tiger Stadium (1-0) | 10-5 | |
| » W: Lerrin LaGrow (1-0) L: Steve Foucault (0-1) | First | -- |
| Wednesday, April 27 |
| » Lost to Tigers (7-11), 10-9 | Tiger Stadium (1-1) | 10-6 | |
| » W: Fernando Arroyo (1-2) L: Bruce Dal Canton (0-1) | Second | 1½ out |
| Friday, April 29 |
| » Lost to Rangers (9-8), 2-1 | Comiskey Park I (5-1) | 10-7 | Lost 2 |
| » W: Doyle Alexander (3-1) L: Steve Stone (1-3) | Third | ½ out |
| Saturday, April 30 |
| » Lost to Rangers (10-8), 14-4 | Comiskey Park I (5-2) | 10-8 | Lost 3 |
| » W: Nelson Briles (2-0) L: Chris Knapp (3-1) | Fourth | 2 out |
| Sunday, May 1 |
| » Defeated Rangers (10-9), 12-4 | Comiskey Park I (6-2) | 11-8 | |
| » W: Ken Brett (3-1) L: Gaylord Perry (1-4) | Third | 2 out |
| Monday, May 2 |
| » Lost to Royals (13-8), 3-1 | Royals Stadium (0-1) | 11-9 | |
| » W: Dennis Leonard (2-1) L: Francisco Barrios (2-1) | Fourth | 1½ out |
| Tuesday, May 3 |
| » Defeated Royals (13-9), 8-4 | Royals Stadium (1-1) | 12-9 | |
| » W: Dave Hamilton (1-0) L: Steve Mingori (0-3) | Third | 1½ out |
| Wednesday, May 4 |
| » Defeated Royals (13-10), 6-3 | Royals Stadium (2-1) | 13-9 | Won 2 |
| » W: Bart Johnson (2-2) L: Jim Colborn (4-2) S: Lerrin LaGrow (4) | Second | 1½ out |
| Thursday, May 5 |
| » Lost to Royals (14-10), 6-5 | Royals Stadium (2-2) | 13-10 | |
| » W: Doug Bird (2-0) L: Ken Brett (3-2) S: Mark Littell (4) | Third | 1 out |
| Friday, May 6 |
| » Defeated Indians (8-14), 7-5 | Cleveland Stadium (1-0) | 14-10 | |
| » W: Francisco Barrios (3-1) L: Dennis Eckersley (2-2) S: Dave Hamilton (2) | Second | 1 out |
| Saturday, May 7 |
| » Defeated Indians (8-15), 5-2 | Cleveland Stadium (2-0) | 15-10 | Won 2 |
| » W: Bart Johnson (3-2) L: Wayne Garland (0-4) | Second | 1 out |
| Sunday, May 8 |
| » Defeated Indians (8-16), 8-3 | Cleveland Stadium (3-0) | 16-10 | Won 3 |
| » W: Steve Stone (2-3) L: Al Fitzmorris (2-3) | Second | 1 out |
| Monday, May 9 |
| » Defeated Rangers (13-11), 6-3 | Arlington Stadium (1-0) | 17-10 | Won 4 |
| » W: Ken Brett (4-2) L: Paul Lindblad (1-1) | Second | ½ out |
| Tuesday, May 10 |
| » Lost to Rangers (14-11), 3-2 | Arlington Stadium (1-1) | 17-11 | |
| » W: Adrian Devine (2-1) L: Dave Hamilton (1-1) | Second | 1½ out |
| Wednesday, May 11 |
| » Defeated Rangers (14-12), 4-3 | Arlington Stadium (2-1) | 18-11 | |
| » W: Chris Knapp (4-1) L: Paul Lindblad (1-2) | Second | ½ out |
| Friday, May 13 |
| » Defeated Indians (11-17), 5-3 | Comiskey Park I (7-2) | 19-11 | Won 2 |
| » W: Steve Stone (3-3) L: Al Fitzmorris (2-4) S: Lerrin LaGrow (5) | Second | ½ out |
| Saturday, May 14 |
| » Defeated Indians (11-18), 18-2 | Comiskey Park I (8-2) | 20-11 | Won 3 |
| » W: Ken Brett (5-2) L: Jim Bibby (2-1) | Second | ½ out |
| Sunday, May 15 |
| » Lost to Indians (12-18), 4-3 | Comiskey Park I (8-3) | 20-12 | |
| » W: Dennis Eckersley (3-2) L: Francisco Barrios (3-2) S: Jim Kern (3) | Second | 1½ out |
| Wednesday, May 18 |
| » Defeated Royals (17-17), 7-4 | Comiskey Park I (9-3) | 21-12 | |
| » W: Chris Knapp (5-1) L: Dennis Leonard (2-3) S: Lerrin LaGrow (6) | Second | 2 out |
| Thursday, May 19 |
| » Defeated Royals (17-18), 8-3 | Comiskey Park I (10-3) | 22-12 | Won 2 |
| » W: Steve Stone (4-3) L: Jim Colborn (5-4) | Second | 1 out |
| Friday, May 20 |
| » Lost to Tigers (15-20), 7-4 | Comiskey Park I (10-4) | 22-13 | |
| » W: Steve Foucault (3-1) L: Ken Brett (5-3) | Second | 1 out |
| Saturday, May 21 |
| » Lost to Tigers (16-20), 3-2 | Comiskey Park I (10-5) | 22-14 | Lost 2 |
| » W: Fernando Arroyo (3-2) L: Francisco Barrios (3-3) | Second | 1 out |
| Sunday, May 22 |
| » Lost to Tigers (17-20), 14-3 | Comiskey Park I (10-6) | 22-15 | Lost 3 |
| » W: Dave Rozema (4-1) L: Wilbur Wood (0-1) | Second | 2 out |
| Wednesday, May 25 |
| » Lost to Brewers (22-22), 7-4 | County Stadium (0-1) | 22-16 | Lost 4 |
| » W: Moose Haas (4-2) L: Chris Knapp (5-2) | Second | 3½ out |
| Thursday, May 26 |
| » Defeated Brewers (22-23), 4-3 | County Stadium (1-1) | 23-16 | |
| » W: Steve Stone (5-3) L: Eduardo Rodriguez (1-1) S: Lerrin LaGrow (7) | Second | 3 out |
| Friday, May 27 |
| » Lost to Yankees (24-19), 8-6 | Yankee Stadium (0-1) | 23-17 | |
| » W: Dick Tidrow (4-2) L: Bruce Dal Canton (0-2) S: Sparky Lyle (8) | Second | 3 out |
| Future White Sox Mike Caruso is born in Queens, NY. |
| Saturday, May 28 |
| » Defeated Yankees (24-20), 9-4 | Yankee Stadium (1-1) | 24-17 | |
| » W: Francisco Barrios (4-3) L: Ron Guidry (3-1) | Second | 2 out |
| Sunday, May 29 |
| » Lost to Yankees (25-20), 5-2 | Yankee Stadium (1-2) | 24-18 | |
| » W: Ed Figueroa (6-3) L: Ken Kravec (0-1) | Second | 3 out |
| Monday, May 30 |
| » Lost to Brewers (25-24), 4-3 | Comiskey Park I (10-7) | 24-19 | Lost 2 |
| » W: Jim Slaton (3-5) L: Dave Hamilton (1-2) | Second | 2½ out |
| » Defeated Brewers (25-25), 8-3 | Comiskey Park I (11-7) | 25-19 | |
| » W: Steve Stone (6-3) L: Eduardo Rodriguez (1-2) | Second | 2½ out |
| Wednesday, June 1 |
| » Defeated Orioles (26-19), 4-2 | Comiskey Park I (12-7) | 26-19 | Won 2 |
| » W: Ken Brett (6-3) L: Jim Palmer (7-4) | Second | 3 out |
| Thursday, June 2 |
| » Defeated Orioles (26-20), 7-4 | Comiskey Park I (13-7) | 27-19 | Won 3 |
| » W: Francisco Barrios (5-3) L: Mike Flanagan (1-4) S: Dave Hamilton (3) | Second | 2 out |
| Friday, June 3 |
| » Defeated Yankees (27-23), 9-5 | Comiskey Park I (14-7) | 28-19 | Won 4 |
| » W: Ken Kravec (1-1) L: Mike Torrez (6-4) S: Lerrin LaGrow (8) | Second | 2 out |
| Saturday, June 4 |
| » Lost to Yankees (28-23), 8-6 | Comiskey Park I (14-8) | 28-20 | |
| » W: Don Gullett (4-2) L: Bart Johnson (3-3) S: Sparky Lyle (10) | Second | 2 out |
| Sunday, June 5 |
| » Lost to Yankees (29-23), 8-6 | Comiskey Park I (14-9) | 28-21 | Lost 2 |
| » W: Dick Tidrow (5-2) L: Steve Stone (6-4) S: Sparky Lyle (11) | Second | 2 out |
| Monday, June 6 |
| » Defeated Twins (31-21), 9-5 | Metropolitan Stadium (1-0) | 29-21 | |
| » W: Lerrin LaGrow (2-0) L: Ron Schueler (2-3) | Second | 1 out |
| Tuesday, June 7 |
| » Lost to Twins (32-21), 6-5 | Metropolitan Stadium (1-1) | 29-22 | |
| » W: Tom Johnson (6-2) L: Larry Anderson (0-1) | Second | 2 out |
| Wednesday, June 8 |
| » Lost to Rangers (26-24), 6-1 | Arlington Stadium (2-2) | 29-23 | Lost 2 |
| » W: Bert Blyleven (5-7) L: Ken Kravec (1-2) | Second | 3 out |
| Thursday, June 9 |
| » Defeated Rangers (26-25), 4-3 | Arlington Stadium (3-2) | 30-23 | |
| » W: Larry Anderson (1-1) L: Adrian Devine (4-2) | Second | 2 out |
| Friday, June 10 |
| » Lost to Orioles (30-25), 6-1 | Memorial Stadium (0-1) | 30-24 | |
| » W: Mike Flanagan (2-5) L: Steve Stone (6-5) | Second | 2 out |
| Saturday, June 11 |
| » Lost to Orioles (31-25), 4-1 | Memorial Stadium (0-2) | 30-25 | Lost 2 |
| » W: Rudy May (8-5) L: Ken Brett (6-4) S: Dennis Martinez (2) | Second | 2 out |
| Sunday, June 12 |
| » Defeated Orioles (31-26), 6-4 | Memorial Stadium (1-2) | 31-25 | |
| » W: Lerrin LaGrow (3-0) L: Dennis Martinez (4-4) | Second | 2 out |
| Monday, June 13 |
| » Lost to Red Sox (33-24), 5-4 | Fenway Park (0-1) | 31-26 | |
| » W: Bill Campbell (5-3) L: Larry Anderson (1-2) | Second | 2½ out |
| Tuesday, June 14 |
| » Lost to Red Sox (34-24), 7-1 | Fenway Park (0-2) | 31-27 | Lost 2 |
| » W: Rick Wise (3-2) L: Chris Knapp (5-3) S: Bill Campbell (12) | Second | 2½ out |
| Thursday, June 16 |
| » Defeated Red Sox (34-25), 7-3 | Fenway Park (1-2) | 32-27 | |
| » W: Steve Stone (7-5) L: Luis Tiant (4-5) S: Lerrin LaGrow (9) | Second | 3 out |
| Saturday, June 18 |
| » Defeated Athletics (28-32), 2-0 | Comiskey Park I (15-9) | 33-27 | Won 2 |
| » W: Ken Kravec (2-2) L: Vida Blue (4-8) S: Lerrin LaGrow (10) | Second | 1½ out |
| Sunday, June 19 |
| » Defeated Athletics (28-33), 2-1 | Comiskey Park I (16-9) | 34-27 | Won 3 |
| » W: Wilbur Wood (1-1) L: Mike Norris (2-2) S: Lerrin LaGrow (11) | First | -- |
| » Defeated Athletics (28-34), 5-1 | Comiskey Park I (17-9) | 35-27 | Won 4 |
| » W: Francisco Barrios (6-3) L: Doc Medich (5-3) | First | -- |
| Monday, June 20 |
| » Lost to Athletics (29-34), 7-1 | Comiskey Park I (17-10) | 35-28 | |
| » W: Rick Langford (5-5) L: Chris Knapp (5-4) S: Bob Lacey (4) | First | -- |
| Tuesday, June 21 |
| » Defeated Angels (31-31), 3-2 | Comiskey Park I (18-10) | 36-28 | |
| » W: Steve Stone (8-5) L: Nolan Ryan (9-7) S: Lerrin LaGrow (12) | First | -- |
| Wednesday, June 22 |
| » Defeated Angels (31-32), 6-2 | Comiskey Park I (19-10) | 37-28 | Won 2 |
| » W: Bart Johnson (4-3) L: Ken Brett (6-5) | First | -- |
| Thursday, June 23 |
| » Lost to Angels (32-32), 10-6 | Comiskey Park I (19-11) | 37-29 | |
| » W: Dyar Miller (5-2) L: Larry Anderson (1-3) | First | -- |
| Friday, June 24 |
| » Lost to Twins (39-30), 7-6 | Metropolitan Stadium (1-2) | 37-30 | Lost 2 |
| » W: Tom Johnson (8-2) L: Lerrin LaGrow (3-1) | Second | 1 out |
| Saturday, June 25 |
| » Defeated Twins (39-31), 8-1 | Metropolitan Stadium (2-2) | 38-30 | |
| » W: Chris Knapp (6-4) L: Geoff Zahn (6-6) | First | -- |
| Sunday, June 26 |
| » Lost to Twins (40-31), 19-12 | Metropolitan Stadium (2-3) | 38-31 | |
| » W: Tom Johnson (9-2) L: Steve Stone (8-6) | Second | 1 out |
| Monday, June 27 |
| » Defeated Mariners (33-44), 10-4 | Comiskey Park I (20-11) | 39-31 | |
| » W: Ken Kravec (3-2) L: Dick Pole (4-4) S: Bart Johnson (1) | Second | 1 out |
| Tuesday, June 28 |
| » Defeated Mariners (33-45), 10-4 | Comiskey Park I (21-11) | 40-31 | Won 2 |
| » W: Francisco Barrios (7-3) L: John Montague (5-6) | Second | 1 out |
| Wednesday, June 29 |
| » Lost to Mariners (34-45), 3-1 | Comiskey Park I (21-12) | 40-32 | |
| » W: Tom House (2-1) L: Wilbur Wood (1-2) S: Enrique Romo (5) | Second | 1 out |
| Friday, July 1 |
| » Defeated Twins (42-33), 5-2 | Comiskey Park I (22-12) | 41-32 | |
| » W: Chris Knapp (7-4) L: Dave Goltz (8-5) | First | -- |
| Saturday, July 2 |
| » Defeated Twins (42-34), 13-8 | Comiskey Park I (23-12) | 42-32 | Won 2 |
| » W: Lerrin LaGrow (4-1) L: Tom Johnson (9-3) | First | -- |
| Sunday, July 3 |
| » Defeated Twins (42-35), 6-0 | Comiskey Park I (24-12) | 43-32 | Won 3 |
| » W: Wilbur Wood (2-2) L: Geoff Zahn (6-7) | First | -- |
| » Defeated Twins (42-36), 10-8 | Comiskey Park I (25-12) | 44-32 | Won 4 |
| » W: Ken Kravec (4-2) L: Jeff Holly (2-3) | First | -- |
| Monday, July 4 |
| » Defeated Mariners (35-48), 6-2 | Kingdome (1-0) | 45-32 | Won 5 |
| » W: Francisco Barrios (8-3) L: John Montague (5-7) | First | -- |
| » Major-league debuts: Julio Cruz (Mariners) |
| Tuesday, July 5 |
| » Defeated Mariners (35-49), 4-1 | Kingdome (2-0) | 46-32 | Won 6 |
| » W: Steve Stone (9-6) L: Tom House (2-2) S: Lerrin LaGrow (13) | First | -- |
| Wednesday, July 6 |
| » Defeated Mariners (35-50), 4-2 | Kingdome (3-0) | 47-32 | Won 7 |
| » W: Wilbur Wood (3-2) L: Gary Wheelock (4-6) | First | -- |
| Friday, July 8 |
| » Defeated Tigers (36-45), 10-7 | Tiger Stadium (2-1) | 48-32 | Won 8 |
| » W: Don Kirkwood (2-0) L: Mark Fidrych (6-4) | First | -- |
| Saturday, July 9 |
| » Defeated Tigers (36-46), 5-2 | Tiger Stadium (3-1) | 49-32 | Won 9 |
| » W: Ken Kravec (5-2) L: Fernando Arroyo (5-7) S: Lerrin LaGrow (14) | First | -- |
| Sunday, July 10 |
| » Lost to Tigers (37-46), 6-5 | Tiger Stadium (3-2) | 49-33 | |
| » W: Milt Wilcox (1-0) L: Dave Hamilton (1-3) | First | -- |
| » Major-league debuts: Bob Adams (Tigers) |
| Monday, July 11 |
| » Defeated Royals (45-38), 4-2 | Comiskey Park I (26-12) | 50-33 | |
| » W: Francisco Barrios (9-3) L: Larry Gura (5-4) | First | -- |
| Tuesday, July 12 |
| » Lost to Royals (46-38), 8-3 | Comiskey Park I (26-13) | 50-34 | |
| » W: Dennis Leonard (8-9) L: Steve Stone (9-7) | First | -- |
| Wednesday, July 13 |
| » Defeated Blue Jays (31-55), 6-3 | Comiskey Park I (27-13) | 51-34 | |
| » W: Chris Knapp (8-4) L: Bill Singer (2-8) S: Bart Johnson (2) | First | -- |
| » Lost to Blue Jays (32-55), 5-3 | Comiskey Park I (27-14) | 51-35 | |
| » W: Dave Lemanczyk (8-7) L: Jack Kucek (0-1) | First | -- |
| Thursday, July 14 |
| » Defeated Blue Jays (32-56), 2-1 | Comiskey Park I (28-14) | 52-35 | |
| » W: Ken Kravec (6-2) L: Jerry Garvin (7-9) | First | -- |
| Friday, July 15 |
| » Defeated Red Sox (50-37), 9-7 | Comiskey Park I (29-14) | 53-35 | Won 2 |
| » W: Wilbur Wood (4-2) L: Bob Stanley (6-4) S: Lerrin LaGrow (15) | First | -- |
| Saturday, July 16 |
| » Lost to Red Sox (51-37), 4-3 | Comiskey Park I (29-15) | 53-36 | |
| » W: Rick Wise (6-4) L: Francisco Barrios (9-4) S: Bill Campbell (17) | First | -- |
| Sunday, July 17 |
| » Defeated Red Sox (51-38), 3-2 | Comiskey Park I (30-15) | 54-36 | |
| » W: Steve Stone (10-7) L: Reggie Cleveland (7-6) S: Lerrin LaGrow (16) | First | -- |
| Thursday, July 21 |
| » Major-league debuts: Lenn Sakata (Brewers) |
| Friday, July 22 |
| » Defeated Blue Jays (34-59), 10-3 | Exhibition Stadium (2-2) | 55-36 | Won 2 |
| » W: Wilbur Wood (5-2) L: Jerry Garvin (7-10) S: Lerrin LaGrow (17) | First | -- |
| Saturday, July 23 |
| » Defeated Blue Jays (34-60), 10-3 | Exhibition Stadium (3-2) | 56-36 | Won 3 |
| » W: Ken Kravec (7-2) L: Dave Lemanczyk (8-9) | First | -- |
| Sunday, July 24 |
| » Defeated Red Sox (53-41), 9-6 | Fenway Park (2-2) | 57-36 | Won 4 |
| » W: Francisco Barrios (10-4) L: Fergie Jenkins (7-7) | First | -- |
| Monday, July 25 |
| » Defeated Red Sox (53-42), 8-7 | Fenway Park (3-2) | 58-36 | Won 5 |
| » W: Lerrin LaGrow (5-1) L: Bill Campbell (9-7) | First | -- |
| Tuesday, July 26 |
| » Defeated Tigers (44-53), 8-3 | Comiskey Park I (31-15) | 59-36 | Won 6 |
| » W: Chris Knapp (9-4) L: Dave Roberts (4-10) | First | -- |
| » Major-league debuts: Jack Morris (Tigers) |
| Wednesday, July 27 |
| » Lost to Tigers (45-53), 3-1 | Comiskey Park I (31-16) | 59-37 | |
| » W: Fernando Arroyo (6-9) L: Wilbur Wood (5-3) S: John Hiller (5) | First | -- |
| Friday, July 29 |
| » Defeated Royals (55-41), 11-8 | Comiskey Park I (32-16) | 60-37 | |
| » W: Dave Hamilton (2-3) L: Mark Littell (5-4) | First | -- |
| Saturday, July 30 |
| » Defeated Royals (55-42), 6-4 | Comiskey Park I (33-16) | 61-37 | Won 2 |
| » W: Francisco Barrios (11-4) L: Doug Bird (8-2) S: Dave Hamilton (4) | First | -- |
| Sunday, July 31 |
| » Defeated Royals (55-43), 5-4 | Comiskey Park I (34-16) | 62-37 | Won 3 |
| » W: Lerrin LaGrow (6-1) L: Doug Bird (8-3) | First | -- |
| » Lost to Royals (56-43), 8-4 | Comiskey Park I (34-17) | 62-38 | |
| » W: Dennis Leonard (10-9) L: Chris Knapp (9-5) | First | -- |
| Monday, August 1 |
| » Lost to Rangers (55-45), 11-6 | Comiskey Park I (34-18) | 62-39 | Lost 2 |
| » W: Gaylord Perry (10-8) L: Wilbur Wood (5-4) S: Adrian Devine (9) | First | -- |
| Tuesday, August 2 |
| » Lost to Rangers (56-45), 9-8 | Comiskey Park I (34-19) | 62-40 | Lost 3 |
| » W: Darold Knowles (3-1) L: Bart Johnson (4-4) | First | -- |
| Wednesday, August 3 |
| » Lost to Rangers (57-45), 12-10 | Comiskey Park I (34-20) | 62-41 | Lost 4 |
| » W: Adrian Devine (8-5) L: Don Kirkwood (2-1) | First | -- |
| Thursday, August 4 |
| » Defeated Rangers (57-46), 5-4 | Comiskey Park I (35-20) | 63-41 | |
| » W: Steve Stone (11-7) L: Bert Blyleven (10-10) S: Lerrin LaGrow (18) | First | -- |
| Friday, August 5 |
| » Lost to Royals (59-45), 12-2 | Royals Stadium (2-3) | 63-42 | |
| » W: Dennis Leonard (11-9) L: Chris Knapp (9-6) | First | -- |
| Saturday, August 6 |
| » Lost to Royals (60-45), 6-3 | Royals Stadium (2-4) | 63-43 | Lost 2 |
| » W: Jim Colborn (12-10) L: Dave Hamilton (2-4) S: Doug Bird (2) | First | -- |
| Sunday, August 7 |
| » Lost to Royals (61-45), 3-2 | Royals Stadium (2-5) | 63-44 | Lost 3 |
| » W: Marty Pattin (4-2) L: Ken Kravec (7-3) | First | -- |
| Monday, August 8 |
| » Defeated Mariners (48-65), 5-4 | Comiskey Park I (36-20) | 64-44 | |
| » W: Randy Wiles (1-0) L: Enrique Romo (5-8) | First | -- |
| Tuesday, August 9 |
| » Defeated Mariners (48-66), 13-3 | Comiskey Park I (37-20) | 65-44 | Won 2 |
| » W: Steve Stone (12-7) L: Gary Wheelock (6-8) | First | -- |
| Wednesday, August 10 |
| » Lost to Indians (47-62), 6-1 | Comiskey Park I (37-21) | 65-45 | |
| » W: Wayne Garland (9-13) L: Wilbur Wood (5-5) | First | -- |
| Future White Sox Lorenzo Barcelo is born in San Pedro de Macoris, D.R. |
| Thursday, August 11 |
| » Lost to Indians (48-62), 3-1 | Comiskey Park I (37-22) | 65-46 | Lost 2 |
| » W: Rick Waits (6-4) L: Ken Kravec (7-4) S: Jim Kern (14) | First | -- |
| Friday, August 12 |
| » Lost to Rangers (64-48), 10-7 | Arlington Stadium (3-3) | 65-47 | Lost 3 |
| » W: Darold Knowles (5-1) L: Lerrin LaGrow (6-2) | Second | 1½ out |
| Saturday, August 13 |
| » Defeated Rangers (64-49), 6-5 | Arlington Stadium (4-3) | 66-47 | |
| » W: Steve Stone (13-7) L: Bert Blyleven (11-11) S: Dave Hamilton (5) | First | -- |
| Sunday, August 14 |
| » Lost to Rangers (65-49), 12-9 | Arlington Stadium (4-4) | 66-48 | |
| » W: Paul Lindblad (4-3) L: Bart Johnson (4-5) S: Dock Ellis (1) | First | -- |
| Monday, August 15 |
| » Lost to Yankees (66-50), 6-2 | Yankee Stadium (1-3) | 66-49 | Lost 2 |
| » W: Mike Torrez (13-10) L: Ken Kravec (7-5) | Second | 1½ out |
| Tuesday, August 16 |
| » Lost to Yankees (67-50), 11-10 | Yankee Stadium (1-4) | 66-50 | Lost 3 |
| » W: Ken Clay (1-3) L: Randy Wiles (1-1) | Second | 1½ out |
| Friday, August 19 |
| » Defeated Brewers (53-72), 3-1 | County Stadium (2-1) | 67-50 | |
| » W: Wilbur Wood (6-5) L: Jim Slaton (8-13) | First | -- |
| Saturday, August 20 |
| » Lost to Brewers (54-72), 4-2 | County Stadium (2-2) | 67-51 | |
| » W: Jerry Augustine (11-14) L: Steve Stone (13-8) S: Eduardo Rodriguez (1) | Second | ½ out |
| Sunday, August 21 |
| » Lost to Brewers (55-72), 7-1 | County Stadium (2-3) | 67-52 | Lost 2 |
| » W: Moose Haas (9-8) L: Ken Kravec (7-6) | Second | 1 out |
| » Defeated Brewers (55-73), 6-3 | County Stadium (3-3) | 68-52 | |
| » W: Steve Renko (3-2) L: Bill Travers (4-7) S: Lerrin LaGrow (19) | Second | 1 out |
| Monday, August 22 |
| » Defeated Yankees (72-51), 5-3 | Comiskey Park I (38-22) | 69-52 | Won 2 |
| » W: Francisco Barrios (12-4) L: Ed Figueroa (12-9) | Second | 1 out |
| Tuesday, August 23 |
| » Lost to Yankees (73-51), 8-3 | Comiskey Park I (38-23) | 69-53 | |
| » W: Mike Torrez (15-10) L: Wilbur Wood (6-6) | Third | 2 out |
| Former White Sox Bubber Jonnard dies in New York, NY at the age of 80. |
| Wednesday, August 24 |
| » Lost to Orioles (71-52), 10-5 | Memorial Stadium (1-3) | 69-54 | Lost 2 |
| » W: Scott McGregor (2-2) L: Steve Stone (13-9) | Fourth | 3 out |
| Thursday, August 25 |
| » Defeated Orioles (71-53), 6-4 | Memorial Stadium (2-3) | 70-54 | |
| » W: Dave Hamilton (3-4) L: Dennis Martinez (11-7) S: Lerrin LaGrow (20) | Second | 3 out |
| Friday, August 26 |
| » Defeated Brewers (56-77), 4-2 | Comiskey Park I (39-23) | 71-54 | Won 2 |
| » W: Steve Renko (4-2) L: Moose Haas (9-9) S: Silvio Martinez (1) | Second | 3 out |
| Saturday, August 27 |
| » Defeated Brewers (56-78), 7-6 | Comiskey Park I (40-23) | 72-54 | Won 3 |
| » W: Lerrin LaGrow (7-2) L: Eduardo Rodriguez (3-6) | Second | 2 out |
| Sunday, August 28 |
| » Lost to Brewers (57-78), 10-1 | Comiskey Park I (40-24) | 72-55 | |
| » W: Lary Sorensen (5-7) L: Wilbur Wood (6-7) | Second | 3 out |
| Monday, August 29 |
| » Lost to Indians (61-69), 9-2 | Cleveland Stadium (3-1) | 72-56 | Lost 2 |
| » W: Rick Waits (8-5) L: Steve Stone (13-10) | Third | 3 out |
| Future White Sox Aaron Rowand is born in Portland, OR. |
| Tuesday, August 30 |
| » Defeated Indians (61-70), 3-1 | Cleveland Stadium (4-1) | 73-56 | |
| » W: Ken Kravec (8-6) L: Wayne Garland (10-16) S: Dave Hamilton (6) | Second | 2 out |
| Future White Sox Jon Adkins is born in Huntington, WV. |
| Friday, September 2 |
| » Lost to Orioles (76-55), 6-5 | Comiskey Park I (40-25) | 73-57 | |
| » W: Dick Drago (6-3) L: Lerrin LaGrow (7-3) S: Tippy Martinez (7) | Second | 4 out |
| Saturday, September 3 |
| » Defeated Orioles (76-56), 6-3 | Comiskey Park I (41-25) | 74-57 | |
| » W: Clay Carroll (5-2) L: Scott McGregor (2-3) | Second | 4 out |
| Sunday, September 4 |
| » Lost to Orioles (77-56), 7-5 | Comiskey Park I (41-26) | 74-58 | |
| » W: Tippy Martinez (5-1) L: Clay Carroll (5-3) | Second | 5 out |
| Monday, September 5 |
| » Lost to Athletics (54-80), 8-7 | Oakland-Alameda County Stadium (2-3) | 74-59 | Lost 2 |
| » W: Doc Medich (9-6) L: Ken Kravec (8-7) S: Doug Bair (5) | Second | 5½ out |
| » Defeated Athletics (54-81), 2-1 | Oakland-Alameda County Stadium (3-3) | 75-59 | |
| » W: Wilbur Wood (7-7) L: Pablo Torrealba (4-5) S: Lerrin LaGrow (21) | Second | 5½ out |
| Tuesday, September 6 |
| » Defeated Athletics (54-82), 7-2 | Oakland-Alameda County Stadium (4-3) | 76-59 | Won 2 |
| » W: Chris Knapp (10-6) L: Vida Blue (13-17) S: Clay Carroll (5) | Second | 5½ out |
| Wednesday, September 7 |
| » Defeated Athletics (54-83), 5-1 | Oakland-Alameda County Stadium (5-3) | 77-59 | Won 3 |
| » W: Steve Renko (5-2) L: Matt Keough (0-1) S: Dave Hamilton (7) | Second | 5½ out |
| Thursday, September 8 |
| » Lost to Angels (65-70), 2-0 | Anaheim Stadium (1-2) | 77-60 | |
| » W: Nolan Ryan (19-13) L: Francisco Barrios (12-5) S: Dave LaRoche (14) | Second | 7 out |
| » Lost to Angels (66-70), 3-2 | Anaheim Stadium (1-3) | 77-61 | Lost 2 |
| » W: Mike Barlow (1-2) L: Clay Carroll (5-4) | Second | 7 out |
| Friday, September 9 |
| » Defeated Angels (66-71), 4-1 | Anaheim Stadium (2-3) | 78-61 | |
| » W: Steve Stone (14-10) L: Ken Brett (12-11) S: Lerrin LaGrow (22) | Second | 7 out |
| Saturday, September 10 |
| » Lost to Angels (67-71), 6-1 | Anaheim Stadium (2-4) | 78-62 | |
| » W: John Caneira (1-0) L: Wilbur Wood (7-8) | Second | 8 out |
| Sunday, September 11 |
| » Defeated Angels (67-72), 6-2 | Anaheim Stadium (3-4) | 79-62 | |
| » W: Chris Knapp (11-6) L: Paul Hartzell (7-10) | Second | 8½ out |
| » Lost to Angels (68-72), 5-4 | Anaheim Stadium (3-5) | 79-63 | |
| » W: Mike Barlow (2-2) L: Silvio Martinez (0-1) S: Dave LaRoche (15) | Second | 8½ out |
| » Major-league debuts: Ken Landreaux (Angels) Dave Frost (White Sox) |
| Monday, September 12 |
| » Defeated Twins (77-67), 7-3 | Comiskey Park I (42-26) | 80-63 | |
| » W: Dave Hamilton (4-4) L: Tom Burgmeier (6-4) | Second | 8 out |
| Tuesday, September 13 |
| » Defeated Twins (77-68), 6-1 | Comiskey Park I (43-26) | 81-63 | Won 2 |
| » W: Francisco Barrios (13-5) L: Paul Thormodsgard (11-12) | Second | 7½ out |
| Wednesday, September 14 |
| » Lost to Twins (78-68), 7-0 | Comiskey Park I (43-27) | 81-64 | |
| » W: Dave Goltz (18-9) L: Ken Kravec (8-8) | Second | 9 out |
| Thursday, September 15 |
|