| Monday, January 3 |
| Future Indian Zach Sorensen is born in Salt Lake City, UT. |
| Sunday, January 16 |
| Former Indian Baby Doll Jacobson dies in Orion, IL at the age of 87. |
| Thursday, January 27 |
| Future Indian Jason Stanford is born in Tucson, AZ. |
| Friday, February 4 |
| Former Indian Nemo Leibold dies in Detroit, MI at the age of 85. |
| Wednesday, April 6 |
| » Major-league debuts: Jose Baez (Mariners) |
| Thursday, April 7 |
| » Defeated Red Sox (0-1), 5-4 | Fenway Park (1-0) | 1-0 | |
| » W: Dave LaRoche (1-0) L: Bill Campbell (0-1) | First | -- |
| » Major-league debuts: Jim Norris (Indians) |
| Saturday, April 9 |
| Former Indian Roxie Lawson dies in Stockport, IA at the age of 71. |
| Sunday, April 10 |
| » Defeated Red Sox (0-2), 19-9 | Fenway Park (2-0) | 2-0 | Won 2 |
| » W: Dave LaRoche (2-0) L: Bill Campbell (0-2) | First | -- |
| Monday, April 11 |
| » Lost to Rangers (4-0), 3-2 | Arlington Stadium (0-1) | 2-1 | |
| » W: Adrian Devine (1-0) L: Dave LaRoche (2-1) | Second | ½ out |
| Wednesday, April 13 |
| » Defeated Rangers (4-1), 5-3 | Arlington Stadium (1-1) | 3-1 | |
| » W: Dennis Eckersley (1-0) L: Tommy Boggs (0-1) | First | -- |
| Saturday, April 16 |
| » Lost to Red Sox (1-4), 8-4 | Cleveland Stadium (0-1) | 3-2 | |
| » W: Luis Tiant (1-0) L: Wayne Garland (0-1) S: Bob Stanley (1) | Second | 1 out |
| » Major-league debuts: Bob Stanley (Red Sox) |
| Sunday, April 17 |
| » Lost to Red Sox (2-4), 4-1 | Cleveland Stadium (0-2) | 3-3 | Lost 2 |
| » W: Reggie Cleveland (1-0) L: Al Fitzmorris (0-1) | Second | 1½ out |
| » Defeated Red Sox (2-5), 10-5 | Cleveland Stadium (1-2) | 4-3 | |
| » W: Jim Bibby (1-0) L: Tom Murphy (0-1) S: Dave LaRoche (1) | Second | 1½ out |
| Monday, April 18 |
| » Lost to Orioles (4-4), 4-3 | Memorial Stadium (0-1) | 4-4 | |
| » W: Rudy May (1-2) L: Pat Dobson (0-1) S: Dyar Miller (1) | Third | 2 out |
| Tuesday, April 19 |
| » Lost to Orioles (5-4), 6-5 | Memorial Stadium (0-2) | 4-5 | Lost 2 |
| » W: Dyar Miller (1-0) L: Dave LaRoche (2-2) | Fourth | 3 out |
| Former Indian Fred Carisch dies in San Gabriel, CA at the age of 96. |
| Wednesday, April 20 |
| » Lost to Orioles (6-4), 7-2 | Memorial Stadium (0-3) | 4-6 | Lost 3 |
| » W: Scott McGregor (1-0) L: Wayne Garland (0-2) | Fourth | 3 out |
| Saturday, April 23 |
| » Lost to Yankees (5-8), 9-3 | Cleveland Stadium (1-3) | 4-7 | Lost 4 |
| » W: Dock Ellis (1-1) L: Al Fitzmorris (0-2) S: Dick Tidrow (1) | Fifth | 3½ out |
| Sunday, April 24 |
| » Lost to Yankees (6-8), 10-1 | Cleveland Stadium (1-4) | 4-8 | Lost 5 |
| » W: Dick Tidrow (1-1) L: Dennis Eckersley (1-1) S: Ron Guidry (1) | Sixth | 5 out |
| » Lost to Yankees (7-8), 7-1 | Cleveland Stadium (1-5) | 4-9 | Lost 6 |
| » W: Ed Figueroa (1-2) L: Pat Dobson (0-2) | Sixth | 5 out |
| Tuesday, April 26 |
| Future Indian Chris Magruder is born in Tacoma, WA. |
| Wednesday, April 27 |
| » Lost to Blue Jays (9-9), 6-5 | Cleveland Stadium (1-6) | 4-10 | Lost 7 |
| » W: Mike Willis (1-0) L: Jim Kern (0-1) | Sixth | 5½ out |
| Thursday, April 28 |
| » Defeated Blue Jays (9-10), 4-3 | Cleveland Stadium (2-6) | 5-10 | |
| » W: Al Fitzmorris (1-2) L: Jesse Jefferson (0-1) S: Rick Waits (1) | Seventh | 5 out |
| Former Indian Al Smith dies in Brownsville, TX at the age of 70. |
| Friday, April 29 |
| » Lost to Brewers (11-5), 6-5 | County Stadium (0-1) | 5-11 | |
| » W: Bill Travers (3-2) L: Pat Dobson (0-3) S: Bob McClure (2) | Seventh | 6 out |
| Saturday, April 30 |
| » Defeated Brewers (11-6), 1-0 | County Stadium (1-1) | 6-11 | |
| » W: Dennis Eckersley (2-1) L: Jim Slaton (1-1) S: Dave LaRoche (2) | Seventh | 5 out |
| Sunday, May 1 |
| » Lost to Brewers (12-6), 7-3 | County Stadium (1-2) | 6-12 | |
| » W: Jerry Augustine (3-2) L: Wayne Garland (0-3) | Seventh | 5 out |
| » Defeated Brewers (12-7), 8-5 | County Stadium (2-2) | 7-12 | |
| » W: Al Fitzmorris (2-2) L: Gary Beare (1-1) S: Jim Kern (1) | Seventh | 5 out |
| Tuesday, May 3 |
| » Lost to Twins (15-9), 4-3 | Cleveland Stadium (2-7) | 7-13 | |
| » W: Tom Burgmeier (3-1) L: Jim Kern (0-2) S: Tom Johnson (3) | Seventh | 6½ out |
| Wednesday, May 4 |
| » Defeated Twins (15-10), 6-5 | Cleveland Stadium (3-7) | 8-13 | |
| » W: Don Hood (1-0) L: Tom Johnson (3-2) S: Dave LaRoche (3) | Sixth | 5½ out |
| Friday, May 6 |
| » Lost to White Sox (14-10), 7-5 | Cleveland Stadium (3-8) | 8-14 | |
| » W: Francisco Barrios (3-1) L: Dennis Eckersley (2-2) S: Dave Hamilton (2) | Sixth | 5 out |
| Saturday, May 7 |
| » Lost to White Sox (15-10), 5-2 | Cleveland Stadium (3-9) | 8-15 | Lost 2 |
| » W: Bart Johnson (3-2) L: Wayne Garland (0-4) | Seventh | 6 out |
| Sunday, May 8 |
| » Lost to White Sox (16-10), 8-3 | Cleveland Stadium (3-10) | 8-16 | Lost 3 |
| » W: Steve Stone (2-3) L: Al Fitzmorris (2-3) | Seventh | 7 out |
| Former Indian Frankie Pytlak dies in Buffalo, NY at the age of 69. |
| Tuesday, May 10 |
| » Defeated Brewers (15-12), 1-0 | Cleveland Stadium (4-10) | 9-16 | |
| » W: Jim Bibby (2-0) L: Jim Slaton (1-3) | Sixth | 6 out |
| » Defeated Brewers (15-13), 7-4 | Cleveland Stadium (5-10) | 10-16 | Won 2 |
| » W: Jim Kern (1-2) L: Gary Beare (1-2) S: Dave LaRoche (4) | Sixth | 6 out |
| Wednesday, May 11 |
| » Defeated Brewers (15-14), 4-3 | Cleveland Stadium (6-10) | 11-16 | Won 3 |
| » W: Wayne Garland (1-4) L: Jerry Augustine (3-4) S: Jim Kern (2) | Sixth | 5 out |
| Friday, May 13 |
| » Lost to White Sox (19-11), 5-3 | Comiskey Park I (0-1) | 11-17 | |
| » W: Steve Stone (3-3) L: Al Fitzmorris (2-4) S: Lerrin LaGrow (5) | Seventh | 5½ out |
| Saturday, May 14 |
| » Lost to White Sox (20-11), 18-2 | Comiskey Park I (0-2) | 11-18 | Lost 2 |
| » W: Ken Brett (5-2) L: Jim Bibby (2-1) | Seventh | 6½ out |
| Sunday, May 15 |
| » Defeated White Sox (20-12), 4-3 | Comiskey Park I (1-2) | 12-18 | |
| » W: Dennis Eckersley (3-2) L: Francisco Barrios (3-2) S: Jim Kern (3) | Seventh | 6 out |
| Monday, May 16 |
| » Lost to Twins (23-11), 8-1 | Metropolitan Stadium (0-1) | 12-19 | |
| » W: Geoff Zahn (6-1) L: Wayne Garland (1-5) | Seventh | 6 out |
| Tuesday, May 17 |
| » Lost to Twins (24-11), 10-4 | Metropolitan Stadium (0-2) | 12-20 | Lost 2 |
| » W: Tom Burgmeier (5-1) L: Pat Dobson (0-4) | Seventh | 6½ out |
| Wednesday, May 18 |
| » Major-league debuts: Tim Corcoran (Tigers) |
| Friday, May 20 |
| » Lost to Royals (18-18), 4-0 | Royals Stadium (0-1) | 12-21 | Lost 3 |
| » W: Paul Splittorff (2-4) L: Dennis Eckersley (3-3) | Seventh | 7 out |
| Saturday, May 21 |
| » Defeated Royals (18-19), 12-7 | Royals Stadium (1-1) | 13-21 | |
| » W: Rick Waits (1-0) L: Mark Littell (4-2) | Seventh | 6½ out |
| Sunday, May 22 |
| » Defeated Royals (18-20), 7-1 | Royals Stadium (2-1) | 14-21 | Won 2 |
| » W: Jim Bibby (3-1) L: Dennis Leonard (2-4) | Seventh | 6 out |
| Tuesday, May 24 |
| » Defeated Mariners (16-29), 7-5 | Cleveland Stadium (7-10) | 15-21 | Won 3 |
| » W: Rick Waits (2-0) L: Enrique Romo (1-3) S: Jim Kern (4) | Sixth | 6½ out |
| Wednesday, May 25 |
| » Defeated Mariners (16-30), 2-1 | Cleveland Stadium (8-10) | 16-21 | Won 4 |
| » W: Dennis Eckersley (4-3) L: Bill Laxton (2-2) | Sixth | 6 out |
| Friday, May 27 |
| » Defeated Athletics (20-22), 3-1 | Cleveland Stadium (9-10) | 17-21 | Won 5 |
| » W: Wayne Garland (2-5) L: Vida Blue (3-5) | Fifth | 6 out |
| Saturday, May 28 |
| » Lost to Athletics (21-22), 5-1 | Cleveland Stadium (9-11) | 17-22 | |
| » W: Doc Medich (4-2) L: Jim Bibby (3-2) S: Bob Lacey (1) | Fifth | 7 out |
| Sunday, May 29 |
| » Defeated Athletics (21-23), 5-4 | Cleveland Stadium (10-11) | 18-22 | |
| » W: Sid Monge (1-1) L: Bob Lacey (1-2) | Fifth | 6 out |
| Monday, May 30 |
| » Defeated Angels (23-23), 1-0 | Cleveland Stadium (11-11) | 19-22 | Won 2 |
| » W: Dennis Eckersley (5-3) L: Frank Tanana (8-2) | Fifth | 6 out |
| Tuesday, May 31 |
| » Lost to Angels (24-23), 7-6 | Cleveland Stadium (11-12) | 19-23 | |
| » W: Dave LaRoche (3-2) L: Jim Kern (1-3) S: Dick Drago (2) | Fifth | 6 out |
| Wednesday, June 1 |
| » Defeated Tigers (18-27), 6-4 | Tiger Stadium (1-0) | 20-23 | |
| » W: Jim Bibby (4-2) L: Mark Fidrych (0-2) S: Sid Monge (2) | Fifth | 5 out |
| Thursday, June 2 |
| » Lost to Tigers (19-27), 4-2 | Tiger Stadium (1-1) | 20-24 | |
| » W: Dave Rozema (5-2) L: Pat Dobson (0-5) S: Steve Foucault (4) | Fifth | 5 out |
| Friday, June 3 |
| » Defeated Mariners (21-33), 7-1 | Kingdome (1-0) | 21-24 | |
| » W: Dennis Eckersley (6-3) L: Rick Jones (0-4) S: Jim Kern (5) | Fifth | 5 out |
| Saturday, June 4 |
| » Defeated Mariners (21-34), 7-5 | Kingdome (2-0) | 22-24 | Won 2 |
| » W: Rick Waits (3-0) L: Mike Kekich (2-1) S: Sid Monge (3) | Fifth | 4½ out |
| Sunday, June 5 |
| » Lost to Mariners (22-34), 6-1 | Kingdome (2-1) | 22-25 | |
| » W: John Montague (5-3) L: Jim Bibby (4-3) | Fifth | 4½ out |
| Monday, June 6 |
| » Defeated Athletics (25-27), 3-1 | Oakland-Alameda County Stadium (1-0) | 23-25 | |
| » W: Pat Dobson (1-5) L: Bob Lacey (2-3) S: Jim Kern (6) | Fifth | 4½ out |
| Wednesday, June 8 |
| » Lost to Athletics (26-27), 3-2 | Oakland-Alameda County Stadium (1-1) | 23-26 | |
| » W: Pablo Torrealba (2-0) L: Dennis Eckersley (6-4) S: Bob Lacey (2) | Fourth | 5 out |
| Friday, June 10 |
| » Lost to Angels (27-26), 1-0 | Anaheim Stadium (0-1) | 23-27 | Lost 2 |
| » W: Frank Tanana (10-2) L: Wayne Garland (2-6) | Fifth | 6½ out |
| Saturday, June 11 |
| » Defeated Angels (27-27), 3-1 | Anaheim Stadium (1-1) | 24-27 | |
| » W: Jim Bibby (5-3) L: Gary Ross (2-4) S: Jim Kern (7) | Fifth | 6½ out |
| Sunday, June 12 |
| » Lost to Angels (28-27), 11-4 | Anaheim Stadium (1-2) | 24-28 | |
| » W: Nolan Ryan (9-5) L: Pat Dobson (1-6) S: Dave LaRoche (7) | Fifth | 6½ out |
| Monday, June 13 |
| » Lost to Rangers (27-27), 3-0 | Cleveland Stadium (11-13) | 24-29 | Lost 2 |
| » W: Bert Blyleven (6-7) L: Dennis Eckersley (6-5) | Fifth | 7 out |
| Tuesday, June 14 |
| » Lost to Rangers (28-27), 7-2 | Cleveland Stadium (11-14) | 24-30 | Lost 3 |
| » W: Gaylord Perry (6-5) L: Wayne Garland (2-7) | Sixth | 8 out |
| Wednesday, June 15 |
| » Lost to Rangers (29-27), 6-0 | Cleveland Stadium (11-15) | 24-31 | Lost 4 |
| » W: Mike Marshall (2-0) L: Jim Bibby (5-4) | Sixth | 8½ out |
| Friday, June 17 |
| » Defeated Tigers (27-32), 8-5 | Cleveland Stadium (12-15) | 25-31 | |
| » W: Jim Kern (2-3) L: Jim Crawford (0-1) | Sixth | 8 out |
| Saturday, June 18 |
| » Defeated Tigers (27-33), 5-4 | Cleveland Stadium (13-15) | 26-31 | Won 2 |
| » W: Dennis Eckersley (7-5) L: Steve Foucault (3-3) | Fifth | 8 out |
| Sunday, June 19 |
| » Defeated Tigers (27-34), 4-2 | Cleveland Stadium (14-15) | 27-31 | Won 3 |
| » Manager: Jeff Torborg |
| » W: Wayne Garland (3-7) L: John Hiller (4-7) | Fourth | 7½ out |
| » Defeated Tigers (27-35), 4-0 | Cleveland Stadium (15-15) | 28-31 | Won 4 |
| » W: Jim Bibby (6-4) L: Fernando Arroyo (5-4) | Fourth | 7½ out |
| Monday, June 20 |
| » Defeated Blue Jays (24-38), 8-5 | Exhibition Stadium (1-0) | 29-31 | Won 5 |
| » W: Pat Dobson (2-6) L: Mike Willis (2-2) S: Jim Kern (8) | Fourth | 7½ out |
| Tuesday, June 21 |
| » Defeated Blue Jays (24-39), 4-0 | Exhibition Stadium (2-0) | 30-31 | Won 6 |
| » W: Rick Waits (4-0) L: Jerry Garvin (7-5) S: Jim Kern (9) | Fourth | 7½ out |
| Wednesday, June 22 |
| » Defeated Blue Jays (24-40), 7-5 | Exhibition Stadium (3-0) | 31-31 | Won 7 |
| » W: Jim Kern (3-3) L: Jerry Johnson (2-3) S: Sid Monge (4) | Fourth | 7½ out |
| Thursday, June 23 |
| » Defeated Blue Jays (24-41), 4-0 | Exhibition Stadium (4-0) | 32-31 | Won 8 |
| » W: Wayne Garland (4-7) L: Jesse Jefferson (3-7) | Fourth | 7½ out |
| Friday, June 24 |
| » Defeated Tigers (29-37), 4-2 | Tiger Stadium (2-1) | 33-31 | Won 9 |
| » W: Jim Bibby (7-4) L: Fernando Arroyo (5-5) | Third | 6½ out |
| Saturday, June 25 |
| » Lost to Tigers (30-37), 6-4 | Tiger Stadium (2-2) | 33-32 | |
| » W: Mark Fidrych (5-2) L: Pat Dobson (2-7) | Fourth | 6½ out |
| Sunday, June 26 |
| » Defeated Tigers (30-38), 5-2 | Tiger Stadium (3-2) | 34-32 | |
| » W: Rick Waits (5-0) L: John Hiller (4-8) S: Jim Kern (10) | Fourth | 6 out |
| » Lost to Tigers (31-38), 3-2 | Tiger Stadium (3-3) | 34-33 | |
| » W: Bob Sykes (1-2) L: Wayne Garland (4-8) | Fourth | 6 out |
| Monday, June 27 |
| » Lost to Orioles (38-34), 9-2 | Cleveland Stadium (15-16) | 34-34 | Lost 2 |
| » W: Mike Flanagan (3-8) L: Dennis Eckersley (7-6) | Fourth | 6 out |
| Wednesday, June 29 |
| » Defeated Orioles (38-35), 11-8 | Cleveland Stadium (16-16) | 35-34 | |
| » W: Jim Bibby (8-4) L: Rudy May (9-7) S: Jim Kern (11) | Fourth | 5 out |
| » Lost to Orioles (39-35), 5-3 | Cleveland Stadium (16-17) | 35-35 | |
| » W: Dick Drago (1-1) L: Jim Kern (3-4) | Fourth | 5 out |
| Thursday, June 30 |
| » Defeated Orioles (39-36), 4-2 | Cleveland Stadium (17-17) | 36-35 | |
| » W: Wayne Garland (5-8) L: Ross Grimsley (7-4) | Fourth | 4½ out |
| Friday, July 1 |
| » Lost to Royals (39-35), 12-2 | Cleveland Stadium (17-18) | 36-36 | |
| » W: Marty Pattin (2-2) L: Rick Waits (5-1) | Fourth | 4½ out |
| Saturday, July 2 |
| » Lost to Royals (40-35), 1-0 | Cleveland Stadium (17-19) | 36-37 | Lost 2 |
| » W: Andy Hassler (5-2) L: Dennis Eckersley (7-7) | Fourth | 5 out |
| Sunday, July 3 |
| » Defeated Royals (40-36), 6-3 | Cleveland Stadium (18-19) | 37-37 | |
| » W: Pat Dobson (3-7) L: Dennis Leonard (6-9) S: Jim Kern (12) | Fourth | 4½ out |
| Monday, July 4 |
| » Lost to Yankees (45-35), 7-5 | Yankee Stadium (0-1) | 37-38 | |
| » W: Ed Figueroa (8-6) L: Wayne Garland (5-9) | Fourth | 5½ out |
| Tuesday, July 5 |
| » Lost to Yankees (46-35), 5-4 | Yankee Stadium (0-2) | 37-39 | Lost 2 |
| » W: Sparky Lyle (7-2) L: Jim Bibby (8-5) | Fourth | 6½ out |
| Thursday, July 7 |
| » Lost to Yankees (47-35), 8-2 | Yankee Stadium (0-3) | 37-40 | Lost 3 |
| » W: Catfish Hunter (5-3) L: Rick Waits (5-2) | Fourth | 7½ out |
| Friday, July 8 |
| » Defeated Blue Jays (30-51), 11-5 | Cleveland Stadium (19-19) | 38-40 | |
| » W: Dennis Eckersley (8-7) L: Dave Lemanczyk (7-7) | Fourth | 7½ out |
| Saturday, July 9 |
| » Defeated Blue Jays (30-52), 3-2 | Cleveland Stadium (20-19) | 39-40 | Won 2 |
| » W: Wayne Garland (6-9) L: Jerry Garvin (7-8) | Fourth | 6½ out |
| Sunday, July 10 |
| » Lost to Blue Jays (31-52), 5-3 | Cleveland Stadium (20-20) | 39-41 | |
| » W: Jeff Byrd (1-2) L: Pat Dobson (3-8) S: Pete Vuckovich (5) | Third | 7 out |
| Monday, July 11 |
| » Lost to Red Sox (48-35), 2-1 | Cleveland Stadium (20-21) | 39-42 | Lost 2 |
| » W: Bob Stanley (6-3) L: Jim Bibby (8-6) | Fourth | 8 out |
| Tuesday, July 12 |
| » Defeated Red Sox (48-36), 7-1 | Cleveland Stadium (21-21) | 40-42 | |
| » W: Dennis Eckersley (9-7) L: Reggie Cleveland (7-5) | Third | 7 out |
| Wednesday, July 13 |
| » Lost to Red Sox (49-36), 9-7 | Cleveland Stadium (21-22) | 40-43 | |
| » W: Bill Campbell (9-5) L: Jim Kern (3-5) S: Bill Lee (1) | Fourth | 8 out |
| Thursday, July 14 |
| » Lost to Red Sox (50-36), 7-4 | Cleveland Stadium (21-23) | 40-44 | Lost 2 |
| » W: Mike Paxton (3-2) L: Al Fitzmorris (2-5) S: Ramon Hernandez (2) | Fourth | 9 out |
| Friday, July 15 |
| » Lost to Rangers (44-43), 8-3 | Arlington Stadium (1-2) | 40-45 | Lost 3 |
| » W: Bert Blyleven (8-9) L: Jim Bibby (8-7) | Fourth | 10 out |
| » Lost to Rangers (45-43), 8-1 | Arlington Stadium (1-3) | 40-46 | Lost 4 |
| » W: Len Barker (1-1) L: Pat Dobson (3-9) S: Nelson Briles (1) | Fourth | 10 out |
| Saturday, July 16 |
| » Lost to Rangers (46-43), 5-4 | Arlington Stadium (1-4) | 40-47 | Lost 5 |
| » W: Doyle Alexander (10-5) L: Jim Kern (3-6) S: Adrian Devine (7) | Fourth | 11 out |
| Sunday, July 17 |
| » Defeated Rangers (46-44), 6-1 | Arlington Stadium (2-4) | 41-47 | |
| » W: Wayne Garland (7-9) L: Dock Ellis (5-9) | Fourth | 10 out |
| Thursday, July 21 |
| » Lost to Red Sox (52-38), 11-4 | Fenway Park (2-1) | 41-48 | |
| » W: Luis Tiant (6-7) L: Wayne Garland (7-10) | Fourth | 10 out |
| » Defeated Red Sox (52-39), 8-2 | Fenway Park (3-1) | 42-48 | |
| » W: Jim Bibby (9-7) L: Bob Stanley (6-5) S: Jim Kern (13) | Fourth | 10 out |
| Friday, July 22 |
| » Lost to Red Sox (53-39), 3-0 | Fenway Park (3-2) | 42-49 | |
| » W: Rick Wise (7-4) L: Al Fitzmorris (2-6) | Fourth | 10½ out |
| Saturday, July 23 |
| » Defeated Red Sox (53-40), 9-8 | Fenway Park (4-2) | 43-49 | |
| » W: Jim Kern (4-6) L: Bill Campbell (9-6) | Fourth | 9½ out |
| Sunday, July 24 |
| » Lost to Rangers (49-44), 4-1 | Cleveland Stadium (21-24) | 43-50 | |
| » W: Doyle Alexander (11-5) L: Wayne Garland (7-11) | Fourth | 10½ out |
| Monday, July 25 |
| » Lost to Rangers (50-44), 6-4 | Cleveland Stadium (21-25) | 43-51 | Lost 2 |
| » W: Nelson Briles (4-4) L: Jim Kern (4-7) S: Adrian Devine (8) | Fifth | 11½ out |
| Tuesday, July 26 |
| » Major-league debuts: Don Aase (Red Sox) |
| Wednesday, July 27 |
| » Lost to Royals (54-40), 5-4 | Royals Stadium (2-2) | 43-52 | Lost 3 |
| » W: Doug Bird (7-1) L: Rick Waits (5-3) | Fifth | 12 out |
| Future Indian Kyle Denney is born in Prague, OK. |
| Thursday, July 28 |
| » Lost to Royals (55-40), 5-4 | Royals Stadium (2-3) | 43-53 | Lost 4 |
| » W: Doug Bird (8-1) L: Dennis Eckersley (9-8) | Fifth | 12 out |
| Friday, July 29 |
| » Lost to Twins (57-45), 3-1 | Cleveland Stadium (21-26) | 43-54 | Lost 5 |
| » W: Paul Thormodsgard (8-8) L: Wayne Garland (7-12) S: Tom Johnson (11) | Sixth | 13 out |
| Saturday, July 30 |
| » Lost to Twins (58-45), 4-3 | Cleveland Stadium (21-27) | 43-55 | Lost 6 |
| » W: Tom Johnson (12-3) L: Sid Monge (1-2) | Sixth | 14 out |
| Sunday, July 31 |
| » Defeated Twins (58-46), 9-2 | Cleveland Stadium (22-27) | 44-55 | |
| » W: Al Fitzmorris (3-6) L: Pete Redfern (4-6) | Sixth | 13½ out |
| » Lost to Twins (59-46), 9-4 | Cleveland Stadium (22-28) | 44-56 | |
| » W: Dave Johnson (2-4) L: Rick Waits (5-4) S: Tom Burgmeier (6) | Sixth | 13½ out |
| Tuesday, August 2 |
| » Defeated Brewers (46-59), 9-2 | County Stadium (3-2) | 45-56 | |
| » W: Dennis Eckersley (10-8) L: Mike Caldwell (2-4) | Fifth | 13 out |
| » Defeated Brewers (46-60), 7-4 | County Stadium (4-2) | 46-56 | Won 2 |
| » W: Wayne Garland (8-12) L: Bill Castro (8-6) | Fifth | 13 out |
| Wednesday, August 3 |
| » Lost to Brewers (47-60), 7-4 | County Stadium (4-3) | 46-57 | |
| » W: Eduardo Rodriguez (2-4) L: Pat Dobson (3-10) | Fifth | 14 out |
| Friday, August 5 |
| » Lost to Twins (63-47), 14-10 | Metropolitan Stadium (0-3) | 46-58 | Lost 2 |
| » W: Geoff Zahn (11-8) L: Sid Monge (1-3) S: Tom Johnson (13) | Fifth | 15½ out |
| Saturday, August 6 |
| » Lost to Twins (64-47), 6-5 | Metropolitan Stadium (0-4) | 46-59 | Lost 3 |
| » W: Pete Redfern (5-7) L: Wayne Garland (8-13) | Fifth | 16½ out |
| Sunday, August 7 |
| » Lost to Twins (65-47), 11-1 | Metropolitan Stadium (0-5) | 46-60 | Lost 4 |
| » W: Dave Goltz (14-6) L: Dennis Eckersley (10-9) | Sixth | 17½ out |
| Monday, August 8 |
| » Lost to Orioles (62-47), 6-3 | Memorial Stadium (0-4) | 46-61 | Lost 5 |
| » W: Dennis Martinez (10-6) L: Jim Bibby (9-8) | Sixth | 18 out |
| Tuesday, August 9 |
| » Lost to Orioles (63-47), 3-1 | Memorial Stadium (0-5) | 46-62 | Lost 6 |
| » W: Ross Grimsley (10-6) L: Al Fitzmorris (3-7) | Sixth | 18½ out |
| Wednesday, August 10 |
| » Defeated White Sox (65-45), 6-1 | Comiskey Park I (2-2) | 47-62 | |
| » W: Wayne Garland (9-13) L: Wilbur Wood (5-5) | Sixth | 18½ out |
| Thursday, August 11 |
| » Defeated White Sox (65-46), 3-1 | Comiskey Park I (3-2) | 48-62 | Won 2 |
| » W: Rick Waits (6-4) L: Ken Kravec (7-4) S: Jim Kern (14) | Fifth | 17½ out |
| Friday, August 12 |
| » Defeated Brewers (50-66), 2-0 | Cleveland Stadium (23-28) | 49-62 | Won 3 |
| » W: Dennis Eckersley (11-9) L: Lary Sorensen (3-6) | Fifth | 17 out |
| » Defeated Brewers (50-67), 5-4 | Cleveland Stadium (24-28) | 50-62 | Won 4 |
| » W: Jim Kern (5-7) L: Bob McClure (2-1) | Fifth | 17 out |
| Saturday, August 13 |
| » Lost to Brewers (51-67), 6-1 | Cleveland Stadium (24-29) | 50-63 | |
| » W: Mike Caldwell (3-5) L: Jim Bibby (9-9) | Fifth | 18 out |
| Sunday, August 14 |
| » Defeated Brewers (51-68), 12-4 | Cleveland Stadium (25-29) | 51-63 | |
| » W: Wayne Garland (10-13) L: Jim Slaton (8-12) | Fifth | 17½ out |
| » Defeated Brewers (51-69), 14-5 | Cleveland Stadium (26-29) | 52-63 | Won 2 |
| » W: Al Fitzmorris (4-7) L: Bill Travers (4-6) | Fifth | 17½ out |
| Monday, August 15 |
| » Defeated Athletics (43-73), 7-2 | Cleveland Stadium (27-29) | 53-63 | Won 3 |
| » W: Rick Waits (7-4) L: Jim Umbarger (1-4) | Fifth | 17½ out |
| Tuesday, August 16 |
| » Lost to Athletics (44-73), 7-3 | Cleveland Stadium (27-30) | 53-64 | |
| » W: Vida Blue (11-15) L: Dennis Eckersley (11-10) | Fifth | 18½ out |
| Wednesday, August 17 |
| » Lost to Royals (65-51), 5-3 | Cleveland Stadium (27-31) | 53-65 | Lost 2 |
| » W: Marty Pattin (6-2) L: Jim Bibby (9-10) S: Doug Bird (5) | Fifth | 18½ out |
| Thursday, August 18 |
| » Lost to Royals (66-51), 4-0 | Cleveland Stadium (27-32) | 53-66 | Lost 3 |
| » W: Dennis Leonard (13-10) L: Wayne Garland (10-14) | Fifth | 19½ out |
| Friday, August 19 |
| » Defeated Athletics (44-74), 2-1 | Oakland-Alameda County Stadium (2-1) | 54-66 | |
| » W: Al Fitzmorris (5-7) L: Joe Coleman (2-4) S: Jim Kern (15) | Fifth | 18½ out |
| Saturday, August 20 |
| » Defeated Athletics (44-75), 5-4 | Oakland-Alameda County Stadium (3-1) | 55-66 | Won 2 |
| » W: Jim Kern (6-7) L: Doug Bair (1-2) | Fifth | 17½ out |
| Sunday, August 21 |
| » Defeated Athletics (44-76), 4-1 | Oakland-Alameda County Stadium (4-1) | 56-66 | Won 3 |
| » W: Dennis Eckersley (12-10) L: Rick Langford (8-14) | Fifth | 16½ out |
| Monday, August 22 |
| » Defeated Mariners (50-77), 12-1 | Kingdome (3-1) | 57-66 | Won 4 |
| » W: Jim Bibby (10-10) L: Bob Galasso (0-4) | Fifth | 16 out |
| » Lost to Mariners (51-77), 4-3 | Kingdome (3-2) | 57-67 | |
| » W: John Montague (6-10) L: Wayne Garland (10-15) | Fifth | 16 out |
| Wednesday, August 24 |
| » Defeated Angels (59-63), 5-3 | Anaheim Stadium (2-2) | 58-67 | |
| » W: Al Fitzmorris (6-7) L: Nolan Ryan (17-12) S: Jim Kern (16) | Fourth | 16½ out |
| » Lost to Angels (60-63), 5-2 | Anaheim Stadium (2-3) | 58-68 | |
| » W: Ken Brett (11-9) L: Rick Waits (7-5) S: Dave LaRoche (13) | Fourth | 16½ out |
| Thursday, August 25 |
| » Major-league debuts: Sam Bowen (Red Sox) |
| Friday, August 26 |
| » Lost to Mariners (52-79), 4-2 | Cleveland Stadium (27-33) | 58-69 | Lost 2 |
| » W: Enrique Romo (6-9) L: Jim Kern (6-8) | Fifth | 18 out |
| Saturday, August 27 |
| » Defeated Mariners (52-80), 10-0 | Cleveland Stadium (28-33) | 59-69 | |
| » W: Dennis Eckersley (13-10) L: Bob Galasso (0-5) | Fifth | 17 out |
| Sunday, August 28 |
| » Defeated Mariners (52-81), 10-6 | Cleveland Stadium (29-33) | 60-69 | Won 2 |
| » W: Jim Bibby (11-10) L: Glenn Abbott (10-10) | Fifth | 17 out |
| Monday, August 29 |
| » Defeated White Sox (72-56), 9-2 | Cleveland Stadium (30-33) | 61-69 | Won 3 |
| » W: Rick Waits (8-5) L: Steve Stone (13-10) | Fifth | 17 out |
| Tuesday, August 30 |
| » Lost to White Sox (73-56), 3-1 | Cleveland Stadium (30-34) | 61-70 | |
| » W: Ken Kravec (8-6) L: Wayne Garland (10-16) S: Dave Hamilton (6) | Fifth | 18 out |
| Wednesday, August 31 |
| » Defeated Red Sox (75-55), 4-3 | Fenway Park (5-2) | 62-70 | |
| » W: Jim Kern (7-8) L: Bob Stanley (6-7) | Fourth | 18 out |
| Thursday, September 1 |
| » Lost to Red Sox (76-55), 3-1 | Fenway Park (5-3) | 62-71 | |
| » W: Bill Lee (6-3) L: Dennis Eckersley (13-11) S: Reggie Cleveland (2) | Fifth | 18½ out |
| Friday, September 2 |
| » Defeated Angels (61-69), 3-1 | Cleveland Stadium (31-34) | 63-71 | |
| » W: Jim Bibby (12-10) L: Paul Hartzell (6-9) S: Jim Kern (17) | Fifth | 18½ out |
| Saturday, September 3 |
| » Lost to Angels (62-69), 3-2 | Cleveland Stadium (31-35) | 63-72 | |
| » W: Nolan Ryan (18-13) L: Wayne Garland (10-17) | Fifth | 19½ out |
| Sunday, September 4 |
| » Lost to Angels (63-69), 7-3 | Cleveland Stadium (31-36) | 63-73 | Lost 2 |
| » W: Ken Brett (12-10) L: Al Fitzmorris (6-8) | Fifth | 20½ out |
| Monday, September 5 |
| » Defeated Yankees (83-53), 4-3 | Cleveland Stadium (32-36) | 64-73 | |
| » W: Don Hood (2-0) L: Catfish Hunter (9-8) S: Jim Kern (18) | Fifth | 18½ out |
| » Defeated Yankees (83-54), 5-4 | Cleveland Stadium (33-36) | 65-73 | Won 2 |
| » W: Jim Kern (8-8) L: Mike Torrez (15-12) S: Jim Bibby (1) | Fifth | 18½ out |
| Tuesday, September 6 |
| » Lost to Yankees (84-54), 8-3 | Cleveland Stadium (33-37) | 65-74 | |
| » W: Dick Tidrow (9-4) L: Dennis Eckersley (13-12) S: Sparky Lyle (22) | Fifth | 19½ out |
| Wednesday, September 7 |
| » Lost to Yankees (85-54), 4-3 | Cleveland Stadium (33-38) | 65-75 | Lost 2 |
| » W: Ron Guidry (13-6) L: Wayne Garland (10-18) | Fifth | 20½ out |
| Thursday, September 8 |
| » Lost to Yankees (86-54), 4-3 | Cleveland Stadium (33-39) | 65-76 | Lost 3 |
| » W: Ed Figueroa (14-9) L: Jim Bibby (12-11) | Fifth | 21½ out |
| Former Indian Oral Hildebrand dies in Southport, IN at the age of 71. |
| Friday, September 9 |
| » Lost to Orioles (82-58), 7-1 | Memorial Stadium (0-6) | 65-77 | Lost 4 |
| » W: Rudy May (16-12) L: Al Fitzmorris (6-9) | Fifth | 22½ out |
| Saturday, September 10 |
| » Lost to Orioles (83-58), 6-5 | Memorial Stadium (0-7) | 65-78 | Lost 5 |
| » W: Dennis Martinez (13-7) L: Jim Kern (8-9) | Fifth | 22½ out |
| Future Indian Danys Baez is born in Pinar Del Rio, Cuba. |
| Sunday, September 11 |
| » Lost to Orioles (84-58), 9-5 | Memorial Stadium (0-8) | 65-79 | Lost 6 |
| » W: Ross Grimsley (13-8) L: Pat Dobson (3-11) | Fifth | 23 out |
| Monday, September 12 |
| » Defeated Tigers (67-78), 8-1 | Cleveland Stadium (34-39) | 66-79 | |
| » W: Wayne Garland (11-18) L: Jim Crawford (7-6) | Fifth | 22½ out |
| Wednesday, September 14 |
| » Lost to Tigers (68-78), 5-3 | Cleveland Stadium (34-40) | 66-80 | |
| » W: Bob Sykes (5-5) L: Jim Bibby (12-12) S: Bruce Taylor (2) | Fifth | 24½ out |
| » Lost to Tigers (69-78), 2-1 | Cleveland Stadium (34-41) | 66-81 | Lost 2 |
| » W: John Hiller (7-14) L: Jim Kern (8-10) S: Steve Foucault (12) | Fifth | 24½ out |
| Former Indian Beau Bell dies in College Station, TX at the age of 71. |
| Saturday, September 17 |
| » Defeated Blue Jays (49-97), 6-3 | Cleveland Stadium (35-41) | 67-81 | |
| » W: Dennis Eckersley (14-12) L: Jeff Byrd (2-11) S: Pat Dobson (1) | Fifth | 25 out |
| » Lost to Blue Jays (50-97), 6-5 | Cleveland Stadium (35-42) |