| Friday, January 28 |
| Future Blue Jay Bob File is born in Philadelphia, PA. |
| Sunday, February 13 |
| Future Blue Jay Joe Lawrence is born in Lake Charles, LA. |
| Wednesday, April 6 |
| » Major-league debuts: Jose Baez (Mariners) |
| Thursday, April 7 |
| » Defeated White Sox (0-1), 9-5 | Exhibition Stadium (1-0) | 1-0 | |
| » W: Jerry Johnson (1-0) L: Ken Brett (0-1) S: Pete Vuckovich (1) | First | -- |
| » Major-league debuts: Al Woods (Blue Jays) |
| Saturday, April 9 |
| » Lost to White Sox (1-1), 3-2 | Exhibition Stadium (1-1) | 1-1 | |
| » W: Chris Knapp (1-0) L: Dave Lemanczyk (0-1) S: Lerrin LaGrow (1) | Second | ½ out |
| » Major-league debuts: Silvio Martinez (White Sox) |
| Sunday, April 10 |
| » Defeated White Sox (1-2), 3-1 | Exhibition Stadium (2-1) | 2-1 | |
| » W: Jerry Garvin (1-0) L: Steve Stone (0-1) S: Pete Vuckovich (2) | Second | ½ out |
| » Major-league debuts: Jerry Garvin (Blue Jays) |
| Monday, April 11 |
| » Defeated Tigers (0-4), 5-3 | Exhibition Stadium (3-1) | 3-1 | Won 2 |
| » W: Steve Hargan (1-0) L: John Hiller (0-1) | First | -- |
| » Major-league debuts: Dave Rozema (Tigers) |
| Tuesday, April 12 |
| » Lost to Tigers (1-4), 6-1 | Exhibition Stadium (3-2) | 3-2 | |
| » W: Dave Roberts (1-1) L: Bill Singer (0-1) | Second | 1 out |
| Wednesday, April 13 |
| » Defeated Tigers (1-5), 7-6 | Exhibition Stadium (4-2) | 4-2 | |
| » W: Dave Lemanczyk (1-1) L: Fernando Arroyo (0-1) S: Mike Willis (1) | Second | 1 out |
| » Major-league debuts: Mike Willis (Blue Jays) |
| Thursday, April 14 |
| » Defeated Tigers (1-6), 5-3 | Exhibition Stadium (5-2) | 5-2 | Won 2 |
| » W: Jerry Garvin (2-0) L: John Hiller (0-2) | Second | 1½ out |
| Friday, April 15 |
| » Lost to White Sox (4-2), 7-5 | Comiskey Park I (0-1) | 5-3 | |
| » W: Francisco Barrios (1-0) L: Jerry Johnson (1-1) | Third | 2 out |
| Saturday, April 16 |
| » Lost to White Sox (5-2), 3-2 | Comiskey Park I (0-2) | 5-4 | Lost 2 |
| » W: Steve Stone (1-1) L: Pete Vuckovich (0-1) | Third | 1 out |
| Sunday, April 17 |
| » Lost to White Sox (6-2), 4-2 | Comiskey Park I (0-3) | 5-5 | Lost 3 |
| » W: Ken Brett (2-1) L: Bill Singer (0-2) S: Bruce Dal Canton (1) | Third | 2 out |
| Monday, April 18 |
| » Defeated Yankees (2-7), 5-1 | Yankee Stadium (1-0) | 6-5 | |
| » W: Dave Lemanczyk (2-1) L: Ed Figueroa (0-2) | Second | 1½ out |
| Tuesday, April 19 |
| » Defeated Yankees (2-8), 8-3 | Yankee Stadium (2-0) | 7-5 | Won 2 |
| » W: Jerry Garvin (3-0) L: Gil Patterson (0-1) | Second | 1½ out |
| » Major-league debuts: Gil Patterson (Yankees) |
| Wednesday, April 20 |
| » Lost to Yankees (3-8), 7-5 | Yankee Stadium (2-1) | 7-6 | |
| » W: Don Gullett (1-2) L: Steve Hargan (1-1) S: Sparky Lyle (2) | Third | 1½ out |
| Thursday, April 21 |
| » Lost to Yankees (4-8), 8-6 | Yankee Stadium (2-2) | 7-7 | Lost 2 |
| » W: Ken Holtzman (1-0) L: Chuck Hartenstein (0-1) S: Sparky Lyle (3) | Third | 2 out |
| Sunday, April 24 |
| » Lost to Red Sox (5-7), 9-0 | Exhibition Stadium (5-3) | 7-8 | Lost 3 |
| » W: Fergie Jenkins (2-1) L: Bill Singer (0-3) | Third | 3 out |
| Monday, April 25 |
| » Defeated Red Sox (5-8), 4-3 | Exhibition Stadium (6-3) | 8-8 | |
| » W: Pete Vuckovich (1-1) L: Bill Campbell (0-3) | Fourth | 3 out |
| » Lost to Red Sox (6-8), 6-5 | Exhibition Stadium (6-4) | 8-9 | |
| » W: Jim Willoughby (1-0) L: Pete Vuckovich (1-2) | Fourth | 3 out |
| Wednesday, April 27 |
| » Defeated Indians (4-10), 6-5 | Cleveland Stadium (1-0) | 9-9 | |
| » W: Mike Willis (1-0) L: Jim Kern (0-1) | Third | 2½ out |
| Thursday, April 28 |
| » Lost to Indians (5-10), 4-3 | Cleveland Stadium (1-1) | 9-10 | |
| » W: Al Fitzmorris (1-2) L: Jesse Jefferson (0-1) S: Rick Waits (1) | Fourth | 3 out |
| Friday, April 29 |
| » Lost to Royals (11-7), 6-1 | Royals Stadium (0-1) | 9-11 | Lost 2 |
| » W: Jim Colborn (4-1) L: Bill Singer (0-4) | Fifth | 4 out |
| Saturday, April 30 |
| » Defeated Royals (11-8), 2-1 | Royals Stadium (1-1) | 10-11 | |
| » W: Jerry Garvin (4-0) L: Paul Splittorff (1-2) | Fifth | 3 out |
| Sunday, May 1 |
| » Lost to Royals (12-8), 8-2 | Royals Stadium (1-2) | 10-12 | |
| » W: Larry Gura (2-0) L: Dave Lemanczyk (2-2) S: Mark Littell (3) | Fifth | 3½ out |
| Monday, May 2 |
| » Lost to Brewers (13-7), 3-1 | Exhibition Stadium (6-5) | 10-13 | Lost 2 |
| » W: Moose Haas (1-1) L: Steve Hargan (1-2) S: Bill Castro (5) | Fourth | 4½ out |
| Tuesday, May 3 |
| » Lost to Brewers (14-7), 6-2 | Exhibition Stadium (6-6) | 10-14 | Lost 3 |
| » W: Barry Cort (1-0) L: Jesse Jefferson (0-2) | Fifth | 5½ out |
| Wednesday, May 4 |
| » Defeated Brewers (14-8), 10-3 | Exhibition Stadium (7-6) | 11-14 | |
| » W: Bill Singer (1-4) L: Jim Slaton (1-2) S: Mike Willis (2) | Fifth | 4½ out |
| Thursday, May 5 |
| » Defeated Brewers (14-9), 9-8 | Exhibition Stadium (8-6) | 12-14 | Won 2 |
| » W: Pete Vuckovich (2-2) L: Bill Castro (3-1) | Fifth | 3½ out |
| Friday, May 6 |
| » Lost to Twins (16-10), 7-2 | Exhibition Stadium (8-7) | 12-15 | |
| » W: Geoff Zahn (5-0) L: Dave Lemanczyk (2-3) S: Ron Schueler (1) | Fourth | 3½ out |
| Saturday, May 7 |
| » Lost to Twins (17-10), 4-1 | Exhibition Stadium (8-8) | 12-16 | Lost 2 |
| » W: Paul Thormodsgard (2-1) L: Steve Hargan (1-3) S: Tom Johnson (4) | Fifth | 4½ out |
| Sunday, May 8 |
| » Lost to Twins (18-10), 5-4 | Exhibition Stadium (8-9) | 12-17 | Lost 3 |
| » W: Dave Goltz (1-2) L: Jesse Jefferson (0-3) S: Tom Johnson (5) | Fifth | 5½ out |
| Monday, May 9 |
| » Defeated Mariners (9-23), 10-4 | Exhibition Stadium (9-9) | 13-17 | |
| » W: Bill Singer (2-4) L: Stan Thomas (1-4) | Fifth | 5 out |
| Tuesday, May 10 |
| » Defeated Mariners (9-24), 9-3 | Exhibition Stadium (10-9) | 14-17 | Won 2 |
| » W: Jerry Garvin (5-0) L: John Montague (3-3) | Fifth | 4½ out |
| Friday, May 13 |
| » Lost to Twins (20-11), 4-3 | Metropolitan Stadium (0-1) | 14-18 | |
| » W: Ron Schueler (2-1) L: Mike Willis (1-1) | Fifth | 4½ out |
| Saturday, May 14 |
| » Lost to Twins (21-11), 13-3 | Metropolitan Stadium (0-2) | 14-19 | Lost 2 |
| » W: Dave Goltz (2-2) L: Bill Singer (2-5) | Sixth | 5½ out |
| Future Blue Jay Roy Halladay is born in Denver, CO. |
| Sunday, May 15 |
| » Lost to Twins (22-11), 5-3 | Metropolitan Stadium (0-3) | 14-20 | Lost 3 |
| » W: Tom Burgmeier (4-1) L: Jerry Garvin (5-1) S: Ron Schueler (2) | Sixth | 6 out |
| Tuesday, May 17 |
| » Defeated Brewers (17-18), 3-1 | County Stadium (1-0) | 15-20 | |
| » W: Jesse Jefferson (1-3) L: Moose Haas (3-2) S: Jerry Johnson (1) | Fifth | 5 out |
| Wednesday, May 18 |
| » Lost to Brewers (18-18), 3-2 | County Stadium (1-1) | 15-21 | |
| » W: Bill Castro (4-1) L: Pete Vuckovich (2-3) | Fifth | 5½ out |
| Thursday, May 19 |
| » Lost to Brewers (19-18), 5-3 | County Stadium (1-2) | 15-22 | Lost 2 |
| » W: Jim Slaton (2-4) L: Bill Singer (2-6) S: Bob McClure (3) | Sixth | 6½ out |
| Friday, May 20 |
| » Defeated Rangers (18-15), 4-3 | Arlington Stadium (1-0) | 16-22 | |
| » W: Jerry Garvin (6-1) L: Bert Blyleven (4-4) | Sixth | 5½ out |
| Saturday, May 21 |
| » Defeated Rangers (18-16), 9-6 | Arlington Stadium (2-0) | 17-22 | Won 2 |
| » W: Jesse Jefferson (2-3) L: Nelson Briles (2-1) S: Mike Willis (3) | Sixth | 5 out |
| » Major-league debuts: Lew Beasley (Rangers) |
| Sunday, May 22 |
| » Lost to Rangers (19-16), 7-4 | Arlington Stadium (2-1) | 17-23 | |
| » W: Doyle Alexander (6-1) L: Dave Lemanczyk (2-4) S: Darold Knowles (2) | Sixth | 5½ out |
| Monday, May 23 |
| » Lost to Athletics (19-21), 3-0 | Exhibition Stadium (10-10) | 17-24 | Lost 2 |
| » W: Rick Langford (4-3) L: Pete Vuckovich (2-4) | Sixth | 6½ out |
| Wednesday, May 25 |
| » Lost to Athletics (20-21), 6-5 | Exhibition Stadium (10-11) | 17-25 | Lost 3 |
| » W: Dave Giusti (1-2) L: Jerry Garvin (6-2) | Seventh | 7½ out |
| Friday, May 27 |
| » Lost to Angels (22-21), 4-1 | Exhibition Stadium (10-12) | 17-26 | Lost 4 |
| » W: Gary Ross (2-2) L: Jerry Johnson (1-2) S: Paul Hartzell (4) | Seventh | 8½ out |
| Saturday, May 28 |
| » Defeated Angels (22-22), 6-4 | Exhibition Stadium (11-12) | 18-26 | |
| » W: Jesse Jefferson (3-3) L: Wayne Simpson (3-4) S: Pete Vuckovich (3) | Seventh | 8½ out |
| Sunday, May 29 |
| » Lost to Angels (23-22), 3-2 | Exhibition Stadium (11-13) | 18-27 | |
| » W: Nolan Ryan (8-4) L: Dave Lemanczyk (2-5) | Seventh | 8½ out |
| Monday, May 30 |
| » Lost to Royals (21-23), 4-1 | Exhibition Stadium (11-14) | 18-28 | Lost 2 |
| » W: Paul Splittorff (4-4) L: Jerry Garvin (6-3) S: Mark Littell (6) | Seventh | 9½ out |
| Wednesday, June 1 |
| » Lost to Royals (22-23), 11-3 | Exhibition Stadium (11-15) | 18-29 | Lost 3 |
| » W: Dennis Leonard (3-5) L: Bill Singer (2-7) | Seventh | 9 out |
| Friday, June 3 |
| » Lost to Athletics (25-24), 3-2 | Oakland-Alameda County Stadium (0-1) | 18-30 | Lost 4 |
| » W: Bob Lacey (2-2) L: Jesse Jefferson (3-4) | Seventh | 9½ out |
| Saturday, June 4 |
| » Defeated Athletics (25-25), 4-2 | Oakland-Alameda County Stadium (1-1) | 19-30 | |
| » W: Dave Lemanczyk (3-5) L: Dock Ellis (2-5) S: Pete Vuckovich (4) | Seventh | 9 out |
| Sunday, June 5 |
| » Defeated Athletics (25-26), 7-3 | Oakland-Alameda County Stadium (2-1) | 20-30 | Won 2 |
| » W: Jerry Garvin (7-3) L: Vida Blue (3-7) S: Jerry Johnson (2) | Seventh | 8 out |
| Tuesday, June 7 |
| » Defeated Angels (25-26), 6-3 | Anaheim Stadium (1-0) | 21-30 | Won 3 |
| » W: Mike Willis (2-1) L: Paul Hartzell (1-5) | Seventh | 7½ out |
| Wednesday, June 8 |
| » Lost to Angels (26-26), 2-1 | Anaheim Stadium (1-1) | 21-31 | |
| » W: Dave LaRoche (4-2) L: Tom Bruno (0-1) | Sixth | 8½ out |
| Friday, June 10 |
| » Defeated Mariners (24-36), 4-3 | Kingdome (1-0) | 22-31 | |
| » W: Dave Lemanczyk (4-5) L: John Montague (5-4) S: Mike Willis (4) | Seventh | 9 out |
| Saturday, June 11 |
| » Defeated Mariners (24-37), 5-4 | Kingdome (2-0) | 23-31 | Won 2 |
| » W: Jerry Johnson (2-2) L: Enrique Romo (3-4) | Seventh | 9 out |
| Sunday, June 12 |
| » Lost to Mariners (25-37), 5-2 | Kingdome (2-1) | 23-32 | |
| » W: Dick Pole (3-2) L: Pete Vuckovich (2-5) | Seventh | 9 out |
| Tuesday, June 14 |
| » Lost to Tigers (25-31), 7-2 | Tiger Stadium (0-1) | 23-33 | Lost 2 |
| » W: John Hiller (4-6) L: Jesse Jefferson (3-5) | Seventh | 10 out |
| Wednesday, June 15 |
| » Lost to Tigers (26-31), 9-0 | Tiger Stadium (0-2) | 23-34 | Lost 3 |
| » W: Fernando Arroyo (5-3) L: Dave Lemanczyk (4-6) | Seventh | 10½ out |
| Thursday, June 16 |
| » Lost to Tigers (27-31), 4-1 | Tiger Stadium (0-3) | 23-35 | Lost 4 |
| » W: Mark Fidrych (3-2) L: Jerry Garvin (7-4) | Seventh | 11 out |
| Friday, June 17 |
| » Lost to Orioles (34-27), 5-3 | Exhibition Stadium (11-16) | 23-36 | Lost 5 |
| » W: Dennis Martinez (6-4) L: Pete Vuckovich (2-6) | Seventh | 11½ out |
| Saturday, June 18 |
| » Lost to Orioles (35-27), 4-2 | Exhibition Stadium (11-17) | 23-37 | Lost 6 |
| » W: Jim Palmer (8-6) L: Jesse Jefferson (3-6) S: Tippy Martinez (2) | Seventh | 12½ out |
| Sunday, June 19 |
| » Defeated Orioles (35-28), 7-1 | Exhibition Stadium (12-17) | 24-37 | |
| » W: Dave Lemanczyk (5-6) L: Mike Flanagan (2-7) | Seventh | 12½ out |
| Monday, June 20 |
| » Lost to Indians (29-31), 8-5 | Exhibition Stadium (12-18) | 24-38 | |
| » W: Pat Dobson (2-6) L: Mike Willis (2-2) S: Jim Kern (8) | Seventh | 13½ out |
| Tuesday, June 21 |
| » Lost to Indians (30-31), 4-0 | Exhibition Stadium (12-19) | 24-39 | Lost 2 |
| » W: Rick Waits (4-0) L: Jerry Garvin (7-5) S: Jim Kern (9) | Seventh | 14½ out |
| Wednesday, June 22 |
| » Lost to Indians (31-31), 7-5 | Exhibition Stadium (12-20) | 24-40 | Lost 3 |
| » W: Jim Kern (3-3) L: Jerry Johnson (2-3) S: Sid Monge (4) | Seventh | 15½ out |
| Thursday, June 23 |
| » Lost to Indians (32-31), 4-0 | Exhibition Stadium (12-21) | 24-41 | Lost 4 |
| » W: Wayne Garland (4-7) L: Jesse Jefferson (3-7) | Seventh | 16½ out |
| Friday, June 24 |
| » Defeated Orioles (35-33), 5-4 | Memorial Stadium (1-0) | 25-41 | |
| » W: Dave Lemanczyk (6-6) L: Fred Holdsworth (0-1) S: Mike Willis (5) | Seventh | 15½ out |
| Saturday, June 25 |
| » Lost to Orioles (36-33), 5-2 | Memorial Stadium (1-1) | 25-42 | |
| » W: Dennis Martinez (7-5) L: Jeff Byrd (0-1) | Seventh | 16 out |
| » Lost to Orioles (37-33), 3-1 | Memorial Stadium (1-2) | 25-43 | Lost 2 |
| » W: Ross Grimsley (7-3) L: Jerry Garvin (7-6) | Seventh | 16 out |
| Sunday, June 26 |
| » Defeated Orioles (37-34), 2-0 | Memorial Stadium (2-2) | 26-43 | |
| » W: Pete Vuckovich (3-6) L: Jim Palmer (8-8) | Seventh | 15 out |
| Monday, June 27 |
| » Defeated Yankees (40-32), 7-6 | Exhibition Stadium (13-21) | 27-43 | Won 2 |
| » W: Jesse Jefferson (4-7) L: Ron Guidry (5-4) S: Jerry Johnson (3) | Seventh | 14 out |
| Tuesday, June 28 |
| » Defeated Yankees (40-33), 8-5 | Exhibition Stadium (14-21) | 28-43 | Won 3 |
| » W: Dave Lemanczyk (7-6) L: Ken Clay (0-2) | Seventh | 13½ out |
| » Lost to Yankees (41-33), 5-1 | Exhibition Stadium (14-22) | 28-44 | |
| » W: Dick Tidrow (6-2) L: Jerry Johnson (2-4) | Seventh | 13½ out |
| Thursday, June 30 |
| » Lost to Yankees (42-33), 11-5 | Exhibition Stadium (14-23) | 28-45 | Lost 2 |
| » W: Catfish Hunter (4-3) L: Jerry Garvin (7-7) | Seventh | 13½ out |
| Friday, July 1 |
| » Lost to Rangers (36-37), 11-8 | Exhibition Stadium (14-24) | 28-46 | Lost 3 |
| » W: Doyle Alexander (7-5) L: Jeff Byrd (0-2) S: Adrian Devine (4) | Seventh | 13½ out |
| Saturday, July 2 |
| » Defeated Rangers (36-38), 10-7 | Exhibition Stadium (15-24) | 29-46 | |
| » W: Pete Vuckovich (4-6) L: Len Barker (0-1) | Seventh | 13 out |
| Sunday, July 3 |
| » Lost to Rangers (37-38), 6-3 | Exhibition Stadium (15-25) | 29-47 | |
| » W: Dock Ellis (4-7) L: Mike Willis (2-3) S: Darold Knowles (3) | Seventh | 13 out |
| » Defeated Rangers (37-39), 5-3 | Exhibition Stadium (16-25) | 30-47 | |
| » W: Jesse Jefferson (5-7) L: Darold Knowles (2-1) | Seventh | 13 out |
| Monday, July 4 |
| » Lost to Red Sox (42-34), 9-6 | Fenway Park (0-1) | 30-48 | |
| » W: Bill Campbell (6-5) L: Chuck Hartenstein (0-2) | Seventh | 14 out |
| Wednesday, July 6 |
| » Lost to Red Sox (43-34), 9-5 | Fenway Park (0-2) | 30-49 | Lost 2 |
| » W: Bill Campbell (7-5) L: Pete Vuckovich (4-7) | Seventh | 15 out |
| Thursday, July 7 |
| » Lost to Red Sox (44-34), 5-2 | Fenway Park (0-3) | 30-50 | Lost 3 |
| » W: Bob Stanley (5-3) L: Jesse Jefferson (5-8) S: Bill Campbell (16) | Seventh | 16 out |
| Friday, July 8 |
| » Lost to Indians (38-40), 11-5 | Cleveland Stadium (1-2) | 30-51 | Lost 4 |
| » W: Dennis Eckersley (8-7) L: Dave Lemanczyk (7-7) | Seventh | 17 out |
| Saturday, July 9 |
| » Lost to Indians (39-40), 3-2 | Cleveland Stadium (1-3) | 30-52 | Lost 5 |
| » W: Wayne Garland (6-9) L: Jerry Garvin (7-8) | Seventh | 17 out |
| Sunday, July 10 |
| » Defeated Indians (39-41), 5-3 | Cleveland Stadium (2-3) | 31-52 | |
| » W: Jeff Byrd (1-2) L: Pat Dobson (3-8) S: Pete Vuckovich (5) | Sixth | 16½ out |
| Monday, July 11 |
| » Lost to Tigers (38-46), 9-7 | Tiger Stadium (0-4) | 31-53 | |
| » W: Steve Grilli (1-0) L: Dennis DeBarr (0-1) | Seventh | 17½ out |
| Tuesday, July 12 |
| » Lost to Tigers (39-46), 2-1 | Tiger Stadium (0-5) | 31-54 | Lost 2 |
| » W: Jim Crawford (3-2) L: Jesse Jefferson (5-9) | Fifth | 17½ out |
| Wednesday, July 13 |
| » Lost to White Sox (51-34), 6-3 | Comiskey Park I (0-4) | 31-55 | Lost 3 |
| » W: Chris Knapp (8-4) L: Bill Singer (2-8) S: Bart Johnson (2) | Seventh | 18 out |
| » Defeated White Sox (51-35), 5-3 | Comiskey Park I (1-4) | 32-55 | |
| » W: Dave Lemanczyk (8-7) L: Jack Kucek (0-1) | Seventh | 18 out |
| Thursday, July 14 |
| » Lost to White Sox (52-35), 2-1 | Comiskey Park I (1-5) | 32-56 | |
| » W: Ken Kravec (6-2) L: Jerry Garvin (7-9) | Seventh | 19 out |
| Friday, July 15 |
| » Defeated Tigers (39-49), 8-6 | Exhibition Stadium (17-25) | 33-56 | |
| » W: Pete Vuckovich (5-7) L: Jim Crawford (3-3) | Seventh | 18½ out |
| Saturday, July 16 |
| » Lost to Tigers (40-49), 11-3 | Exhibition Stadium (17-26) | 33-57 | |
| » W: Dave Rozema (8-4) L: Mike Willis (2-4) | Sixth | 19½ out |
| Sunday, July 17 |
| » Defeated Tigers (40-50), 3-2 | Exhibition Stadium (18-26) | 34-57 | |
| » W: Jesse Jefferson (6-9) L: Fernando Arroyo (5-9) | Seventh | 19 out |
| » Lost to Tigers (41-50), 7-6 | Exhibition Stadium (18-27) | 34-58 | |
| » W: John Hiller (5-9) L: Dave Lemanczyk (8-8) | Seventh | 19 out |
| Thursday, July 21 |
| » Major-league debuts: Lenn Sakata (Brewers) |
| Friday, July 22 |
| » Lost to White Sox (55-36), 10-3 | Exhibition Stadium (18-28) | 34-59 | Lost 2 |
| » W: Wilbur Wood (5-2) L: Jerry Garvin (7-10) S: Lerrin LaGrow (17) | Seventh | 19½ out |
| Saturday, July 23 |
| » Lost to White Sox (56-36), 10-3 | Exhibition Stadium (18-29) | 34-60 | Lost 3 |
| » W: Ken Kravec (7-2) L: Dave Lemanczyk (8-9) | Seventh | 19½ out |
| Sunday, July 24 |
| » Lost to Tigers (43-52), 6-2 | Tiger Stadium (0-6) | 34-61 | Lost 4 |
| » W: Bob Sykes (2-3) L: Jesse Jefferson (6-10) | Seventh | 20½ out |
| Monday, July 25 |
| » Lost to Tigers (44-52), 8-3 | Tiger Stadium (0-7) | 34-62 | Lost 5 |
| » W: Milt Wilcox (2-0) L: Jeff Byrd (1-3) S: Jim Crawford (1) | Seventh | 21½ out |
| Tuesday, July 26 |
| » Lost to Rangers (51-44), 14-0 | Exhibition Stadium (18-30) | 34-63 | Lost 6 |
| » W: Bert Blyleven (10-9) L: Jim Clancy (0-1) | Seventh | 21½ out |
| » Major-league debuts: Jim Clancy (Blue Jays) |
| Thursday, July 28 |
| » Lost to Rangers (52-44), 3-0 | Exhibition Stadium (18-31) | 34-64 | Lost 7 |
| » W: Gaylord Perry (9-8) L: Jerry Garvin (7-11) | Seventh | 22 out |
| Friday, July 29 |
| » Lost to Brewers (45-56), 7-3 | Exhibition Stadium (18-32) | 34-65 | Lost 8 |
| » W: Moose Haas (7-7) L: Jesse Jefferson (6-11) | Seventh | 23 out |
| Saturday, July 30 |
| » Lost to Brewers (46-56), 3-2 | Exhibition Stadium (18-33) | 34-66 | Lost 9 |
| » W: Jim Slaton (8-9) L: Jeff Byrd (1-4) | Seventh | 24 out |
| Sunday, July 31 |
| » Defeated Brewers (46-57), 4-1 | Exhibition Stadium (19-33) | 35-66 | |
| » W: Dave Lemanczyk (9-9) L: Jerry Augustine (10-12) S: Tom Murphy (1) | Seventh | 23 out |
| Monday, August 1 |
| » Defeated Brewers (46-58), 3-2 | Exhibition Stadium (20-33) | 36-66 | Won 2 |
| » W: Jim Clancy (1-1) L: Lary Sorensen (2-5) | Seventh | 23 out |
| Wednesday, August 3 |
| » Lost to Royals (57-45), 7-4 | Royals Stadium (1-3) | 36-67 | |
| » W: Paul Splittorff (9-5) L: Jerry Garvin (7-12) S: Doug Bird (1) | Seventh | 24 out |
| Thursday, August 4 |
| » Lost to Royals (58-45), 8-0 | Royals Stadium (1-4) | 36-68 | Lost 2 |
| » W: Larry Gura (6-5) L: Jesse Jefferson (6-12) | Seventh | 25 out |
| Friday, August 5 |
| » Defeated Brewers (47-61), 6-1 | County Stadium (2-2) | 37-68 | |
| » W: Jeff Byrd (2-4) L: Jim Slaton (8-10) | Seventh | 25 out |
| Future Blue Jay Eric Hinske is born in Menasha, WI. |
| Saturday, August 6 |
| » Defeated Brewers (47-62), 5-3 | County Stadium (3-2) | 38-68 | Won 2 |
| » W: Dave Lemanczyk (10-9) L: Jerry Augustine (10-13) S: Jerry Johnson (4) | Seventh | 25 out |
| Sunday, August 7 |
| » Lost to Brewers (48-62), 6-2 | County Stadium (3-3) | 38-69 | |
| » W: Lary Sorensen (3-5) L: Jerry Garvin (7-13) S: Bob McClure (4) | Seventh | 26½ out |
| » Lost to Brewers (49-62), 7-5 | County Stadium (3-4) | 38-70 | Lost 2 |
| » W: Moose Haas (8-7) L: Jim Clancy (1-2) S: Sam Hinds (2) | Seventh | 26½ out |
| Tuesday, August 9 |
| » Defeated Twins (65-48), 6-2 | Exhibition Stadium (21-33) | 39-70 | |
| » W: Jesse Jefferson (7-12) L: Paul Thormodsgard (9-9) | Seventh | 26 out |
| Future Blue Jay Jason Frasor is born in Chicago, IL. |
| Thursday, August 11 |
| » Lost to Twins (66-48), 7-3 | Exhibition Stadium (21-34) | 39-71 | |
| » W: Dave Goltz (15-6) L: Jeff Byrd (2-5) S: Tom Johnson (14) | Seventh | 26½ out |
| Friday, August 12 |
| » Lost to Royals (63-48), 9-8 | Exhibition Stadium (21-35) | 39-72 | Lost 2 |
| » W: Marty Pattin (5-2) L: Dave Lemanczyk (10-10) S: Doug Bird (3) | Seventh | 27½ out |
| Saturday, August 13 |
| » Lost to Royals (64-48), 5-3 | Exhibition Stadium (21-36) | 39-73 | Lost 3 |
| » W: Paul Splittorff (10-6) L: Jim Clancy (1-3) S: Doug Bird (4) | Seventh | 28½ out |
| Sunday, August 14 |
| » Defeated Royals (64-49), 6-3 | Exhibition Stadium (22-36) | 40-73 | |
| » W: Tom Murphy (1-1) L: Dennis Leonard (12-10) S: Pete Vuckovich (6) | Seventh | 28½ out |
| Monday, August 15 |
| » Lost to Angels (57-58), 7-4 | Exhibition Stadium (22-37) | 40-74 | |
| » W: Frank Tanana (14-7) L: Jesse Jefferson (7-13) | Seventh | 29½ out |
| Tuesday, August 16 |
| » Lost to Angels (58-58), 7-2 | Exhibition Stadium (22-38) | 40-75 | Lost 2 |
| » W: Paul Hartzell (6-7) L: Jeff Byrd (2-6) | Seventh | 30½ out |
| Wednesday, August 17 |
| » Lost to Rangers (67-50), 6-5 | Arlington Stadium (2-2) | 40-76 | Lost 3 |
| » W: Adrian Devine (9-6) L: Mike Willis (2-5) | Seventh | 30½ out |
| Thursday, August 18 |
| » Lost to Rangers (68-50), 8-0 | Arlington Stadium (2-3) | 40-77 | Lost 4 |
| » W: Dock Ellis (7-9) L: Jim Clancy (1-4) | Seventh | 31½ out |
| Friday, August 19 |
| » Defeated Angels (58-59), 3-1 | Anaheim Stadium (2-1) | 41-77 | |
| » W: Jerry Garvin (8-13) L: Nolan Ryan (17-11) S: Pete Vuckovich (7) | Seventh | 30½ out |
| Saturday, August 20 |
| » Defeated Angels (58-60), 5-4 | Anaheim Stadium (3-1) | 42-77 | Won 2 |
| » W: Pete Vuckovich (6-7) L: Dave LaRoche (7-5) | Seventh | 29½ out |
| Sunday, August 21 |
| » Lost to Angels (59-60), 3-2 | Anaheim Stadium (3-2) | 42-78 | |
| » W: Frank Tanana (15-7) L: Jeff Byrd (2-7) | Seventh | 29½ out |
| Monday, August 22 |
| » Lost to Athletics (45-76), 5-2 | Oakland-Alameda County Stadium (2-2) | 42-79 | Lost 2 |
| » W: Doc Medich (6-6) L: Dave Lemanczyk (10-11) S: Bob Lacey (7) | Seventh | 29½ out |
| Tuesday, August 23 |
| » Defeated Athletics (45-77), 8-1 | Oakland-Alameda County Stadium (3-2) | 43-79 | |
| » W: Jim Clancy (2-4) L: Jim Umbarger (1-5) | Seventh | 29 out |
| Wednesday, August 24 |
| » Defeated Mariners (51-78), 7-0 | Kingdome (3-1) | 44-79 | Won 2 |
| » W: Jerry Garvin (9-13) L: Dick Pole (7-11) | Sixth | 28½ out |
| » Defeated Mariners (51-79), 9-3 | Kingdome (4-1) | 45-79 | Won 3 |
| » W: Jesse Jefferson (8-13) L: Glenn Abbott (10-9) | Sixth | 28½ out |
| » Major-league debuts: Rick Honeycutt (Mariners) |
| Friday, August 26 |
| » Lost to Athletics (48-77), 8-4 | Exhibition Stadium (22-39) | 45-80 | |
| » W: Pablo Torrealba (4-4) L: Jeff Byrd (2-8) | Seventh | 30 out |
| Saturday, August 27 |
| » Lost to Athletics (49-77), 9-8 | Exhibition Stadium (22-40) | 45-81 | Lost 2 |
| » W: Doc Medich (7-6) L: Dave Lemanczyk (10-12) S: Doug Bair (2) | Seventh | 30 out |
| Future Blue Jay Justin Miller is born in Torrance, CA. |
| Sunday, August 28 |
| » Lost to Athletics (50-77), 6-2 | Exhibition Stadium (22-41) | 45-82 | Lost 3 |
| » W: Vida Blue (13-15) L: Jim Clancy (2-5) | Seventh | 31 out |
| Monday, August 29 |
| » Lost to Twins (74-58), 7-6 | Metropolitan Stadium (0-4) | 45-83 | Lost 4 |
| » W: Ron Schueler (7-6) L: Tom Murphy (1-2) | Seventh | 32½ out |
| » Lost to Twins (75-58), 6-5 | Metropolitan Stadium (0-5) | 45-84 | Lost 5 |
| » W: Tom Johnson (15-6) L: Mike Willis (2-6) | Seventh | 32½ out |
| Friday, September 2 |
| » Lost to Mariners (53-83), 4-3 | Exhibition Stadium (22-42) | 45-85 | Lost 6 |
| » W: Glenn Abbott (11-10) L: Dave Lemanczyk (10-13) | Seventh | 34½ out |
| Saturday, September 3 |
| » Lost to Mariners (54-83), 6-2 | Exhibition Stadium (22-43) | 45-86 | Lost 7 |
| » W: John Montague (7-10) L: Jesse Jefferson (8-14) S: Enrique Romo (12) | Seventh | 35½ out |
| Sunday, September 4 |
| » Lost to Mariners (55-83), 7-2 | Exhibition Stadium (22-44) | 45-87 | Lost 8 |
| » W: Paul Mitchell (2-5) L: Jerry Garvin (9-14) | Seventh | 36½ out |
| Future Blue Jay Matt DeWitt is born in San Bernardino, CA. |
| Monday, September 5 |
| » Lost to Red Sox (79-56), 8-0 | Exhibition Stadium (22-45) | 45-88 | Lost 9 |
| » W: Don Aase (4-1) L: Jeff Byrd (2-9) | Seventh | 36½ out |
| » Lost to Red Sox (80-56), 6-0 | Exhibition Stadium (22-46) | 45-89 | Lost 10 |
| » W: Reggie Cleveland (9-7) L: Jim Clancy (2-6) | Seventh | 36½ out |
| Tuesday, September 6 |
| » Lost to Red Sox (81-56), 11-2 | Exhibition Stadium (22-47) | 45-90 | Lost 11 |
| » W: Bill Lee (7-3) L: Mike Darr (0-1) | Seventh | 37½ out |
| » Major-league debuts: Mike Darr (Blue Jays) Bo Diaz (Red Sox) |
| Wednesday, September 7 |
| » Defeated Red Sox (81-57), 3-2 | Exhibition Stadium (23-47) | 46-90 | |
| » W: Dave Lemanczyk (11-13) L: Fergie Jenkins (10-10) | Seventh | 37½ out |
| Thursday, September 8 |
| » Lost to Red Sox (82-57), 7-2 | Exhibition Stadium (23-48) | 46-91 | |
| » W: Mike Paxton (9-4) L: Jesse Jefferson (8-15) | Seventh | 38½ out |
| Friday, September 9 |
| » Lost to Yankees (87-54), 2-0 | Yankee Stadium (2-3) | 46-92 | Lost 2 |
| » W: Mike Torrez (16-12) L: Jerry Garvin (9-15) | Seventh | 39½ out |
| Saturday, September 10 |
| » Defeated Yankees (87-55), 19-3 | Yankee Stadium (3-3) | 47-92 | |
| » W: Jim Clancy (3-6) L: Catfish Hunter (9-9) | Seventh | 38½ out |
| Sunday, September 11 |
| » Lost to Yankees (88-55), 4-3 | Yankee Stadium (3-4) | 47-93 | |
| » W: Dick Tidrow (10-4) L: Jeff Byrd (2-10) S: Sparky Lyle (23) | Seventh | 38½ out |
| » Defeated Yankees (88-56), 6-4 | Yankee Stadium (4-4) | 48-93 | |
| » W: Tom Murphy (2-2) L: Don Gullett (11-4) S: Jerry Johnson (5) | Seventh | 38½ out |
| Monday, September 12 |
| » Lost to Orioles (85-58), 6-3 | Exhibition Stadium (23-49) | 48-94 | |
| » W: Jim Palmer (16-11) L: Dave Lemanczyk (11-14) S: Tippy Martinez (8) | Seventh | 39 out |
| Wednesday, September 14 |
| » Lost to Orioles (86-58), 6-5 | Exhibition Stadium (23-50) | 48-95 | Lost 2 |
| » W: Mike Flanagan (12-10) L: Jesse Jefferson (8-16) S: Scott McGregor (3) | Seventh | 41 out |
| » Lost to Orioles (87-58), 4-2 | Exhibition Stadium (23-51) | 48-96 | Lost 3 |
| » W: Rudy May (17-12) L: Jerry Garvin (9-16) S: Scott McGregor (4) | Seventh | 41 out |
| Thursday, September 15 |
| » Defeated Orioles (87-59), 4-0 | Exhibition Stadium (24-51) | 49-96 | |
| » W: Jim Clancy (4-6) L: Ross Grimsley (13-9) | Sixth | 40 out |
| Saturday, September 17 |
| » Lost to Indians (67-81), 6-3 | Cleveland Stadium (2-4) | 49-97 | |
| » W: Dennis Eckersley (14-12) L: Jeff Byrd (2-11) S: Pat Dobson (1) | Seventh | 41 out |
| » Defeated Indians (67-82), 6-5 | Cleveland Stadium (3-4) | 50-97 | |
| » W: Dave Lemanczyk (12-14) L: Rick Waits (8-6) S: Tom Murphy (2) | Seventh | 41 out |
| Sunday, September 18 |
| » Defeated Indians (67-83), 7-4 | Cleveland Stadium (4-4) | 51-97 | Won 2 |
| » W: Jesse Jefferson (9-16) L: Wayne Garland (11-19) S: Pete Vuckovich (8) | Seventh | 41 out |
| Monday, September 19 |
| » Defeated Orioles (89-61), 3-1 | Memorial Stadium (3-2) | 52-97 | Won 3 |
| » W: Jerry Garvin (10-16) L: Rudy May (17-13) | Sixth | 40 out |
| Future Blue Jay Mike Smith is born in Norwood, MA. |
| Tuesday, September 20 |
| » Lost to Orioles (90-61), 5-2 | Memorial Stadium (3-3) | 52-98 | |
| » W: Jim Palmer (18-11) L: Jim Clancy (4-7) | Seventh | 40½ out |
| Wednesday, September 21 |
| » Lost to Orioles (91-61), 4-0 | Memorial Stadium (3-4) | 52-99 | Lost 2 |
| » W: Ross Grimsley (14-9) L: Jeff Byrd (2-12) | Seventh | |