| Wednesday, January 14 |
| Future White Sox Pat Daneker is born in Williamsport, PA. |
| Sunday, February 8 |
| Future White Sox Jim Parque is born in Norwalk, CA. |
| Friday, March 5 |
| Future White Sox Paul Konerko is born in Providence, RI. |
| Saturday, March 13 |
| Former White Sox Johnny Pasek dies in Niagara Falls, NY at the age of 71. |
| Wednesday, March 24 |
| Future White Sox Joe Davenport is born in Chicago, IL. |
| Friday, April 9 |
| » Defeated Royals (0-1), 4-0 | Comiskey Park I (1-0) | 1-0 | |
| » W: Wilbur Wood (1-0) L: Paul Splittorff (0-1) | First | -- |
| Saturday, April 10 |
| » Major-league debuts: Paul Hartzell (Angels) |
| Tuesday, April 13 |
| » Defeated Twins (1-3), 4-1 | Metropolitan Stadium (1-0) | 2-0 | Won 2 |
| » W: Rich Gossage (1-0) L: Bert Blyleven (0-1) | First | -- |
| » Major-league debuts: Bob Randall (Twins) |
| Wednesday, April 14 |
| » Lost to Twins (2-3), 6-2 | Metropolitan Stadium (1-1) | 2-1 | |
| » W: Joe Decker (1-1) L: Wilbur Wood (1-1) S: Bill Campbell (1) | Second | 1½ out |
| Former White Sox Mike McCormick dies in Ventura, CA at the age of 59. |
| Thursday, April 15 |
| » Defeated Red Sox (2-4), 8-4 | Fenway Park (1-0) | 3-1 | |
| » W: Bart Johnson (1-0) L: Rick Wise (0-1) S: Clay Carroll (1) | Second | 1 out |
| Saturday, April 17 |
| » Lost to Red Sox (3-4), 7-1 | Fenway Park (1-1) | 3-2 | |
| » W: Luis Tiant (2-0) L: Rich Gossage (1-1) | Second | 1 out |
| Sunday, April 18 |
| » Defeated Red Sox (3-5), 10-4 | Fenway Park (2-1) | 4-2 | |
| » W: Wilbur Wood (2-1) L: Bill Lee (0-1) | Second | 1½ out |
| » Major-league debuts: Rick Jones (Red Sox) |
| Tuesday, April 20 |
| » Lost to Yankees (6-2), 5-4 | Yankee Stadium (0-1) | 4-3 | |
| » W: Tippy Martinez (1-0) L: Bart Johnson (1-1) S: Sparky Lyle (2) | Second | 1½ out |
| Wednesday, April 21 |
| » Lost to Yankees (7-2), 10-7 | Yankee Stadium (0-2) | 4-4 | Lost 2 |
| » W: Rudy May (1-0) L: Dave Hamilton (0-1) | Third | 1 out |
| Friday, April 23 |
| » Lost to Red Sox (6-5), 9-2 | Comiskey Park I (1-1) | 4-5 | Lost 3 |
| » W: Luis Tiant (3-0) L: Wilbur Wood (2-2) | Fourth | 1 out |
| Tuesday, April 27 |
| Former White Sox Ed Durham dies in Chester, SC at the age of 69. |
| Wednesday, April 28 |
| » Lost to Brewers (8-3), 4-1 | Comiskey Park I (1-2) | 4-6 | Lost 4 |
| » W: Bill Travers (2-0) L: Wilbur Wood (2-3) S: Eduardo Rodriguez (6) | Fourth | 1½ out |
| Thursday, April 29 |
| » Lost to Brewers (9-3), 8-5 | Comiskey Park I (1-3) | 4-7 | Lost 5 |
| » W: Eduardo Rodriguez (1-0) L: Clay Carroll (0-1) | Fourth | 2½ out |
| Friday, April 30 |
| » Defeated Tigers (7-6), 8-4 | Comiskey Park I (2-3) | 5-7 | |
| » W: Terry Forster (1-0) L: Ray Bare (1-1) | Third | 2½ out |
| Saturday, May 1 |
| » Lost to Tigers (8-6), 10-1 | Comiskey Park I (2-4) | 5-8 | |
| » W: Vern Ruhle (1-0) L: Bart Johnson (1-2) | Fifth | 3½ out |
| Tuesday, May 4 |
| » Defeated Orioles (7-11), 3-1 | Memorial Stadium (1-0) | 6-8 | |
| » W: Wilbur Wood (3-3) L: Ken Holtzman (2-1) | Fifth | 4 out |
| Wednesday, May 5 |
| » Lost to Orioles (8-11), 2-0 | Memorial Stadium (1-1) | 6-9 | |
| » W: Jim Palmer (4-3) L: Rich Gossage (1-2) | Fifth | 4½ out |
| Friday, May 7 |
| » Lost to Tigers (9-8), 5-0 | Tiger Stadium (0-1) | 6-10 | Lost 2 |
| » W: Ray Bare (2-1) L: Terry Forster (1-1) | Fifth | 5 out |
| Saturday, May 8 |
| » Lost to Tigers (10-8), 7-1 | Tiger Stadium (0-2) | 6-11 | Lost 3 |
| » W: Vern Ruhle (2-0) L: Bart Johnson (1-3) S: Bill Laxton (2) | Sixth | 6½ out |
| Sunday, May 9 |
| » Defeated Tigers (10-9), 4-2 | Tiger Stadium (1-2) | 7-11 | |
| » W: Wilbur Wood (4-3) L: Joe Coleman (2-1) S: Clay Carroll (2) | Fifth | 6½ out |
| Monday, May 10 |
| » Defeated Rangers (15-7), 7-6 | Arlington Stadium (1-0) | 8-11 | Won 2 |
| » W: Dave Hamilton (1-1) L: Steve Hargan (1-1) | Fifth | 5½ out |
| Tuesday, May 11 |
| » Lost to Rangers (16-7), 6-5 | Arlington Stadium (1-1) | 8-12 | |
| » W: Jeff Terpko (1-1) L: Dave Hamilton (1-2) | Fifth | 6½ out |
| Thursday, May 13 |
| » Lost to Royals (14-9), 13-2 | Royals Stadium (0-1) | 8-13 | Lost 2 |
| » W: Dennis Leonard (2-1) L: Bart Johnson (1-4) | Fifth | 7 out |
| Friday, May 14 |
| » Lost to Royals (15-9), 7-1 | Royals Stadium (0-2) | 8-14 | Lost 3 |
| » W: Al Fitzmorris (4-0) L: Pete Vuckovich (0-1) | Fifth | 8 out |
| Saturday, May 15 |
| » Lost to Royals (16-9), 2-1 | Royals Stadium (0-3) | 8-15 | Lost 4 |
| » W: Mark Littell (2-0) L: Rich Gossage (1-3) | Fifth | 9 out |
| Sunday, May 16 |
| » Defeated Royals (16-10), 4-3 | Royals Stadium (1-3) | 9-15 | |
| » W: Clay Carroll (1-1) L: Doug Bird (3-1) S: Dave Hamilton (1) | Fifth | 8 out |
| Monday, May 17 |
| » Lost to Angels (13-22), 10-5 | Comiskey Park I (2-5) | 9-16 | |
| » W: Frank Tanana (4-3) L: Jesse Jefferson (0-1) | Sixth | 8 out |
| Tuesday, May 18 |
| » Defeated Angels (13-23), 5-0 | Comiskey Park I (3-5) | 10-16 | |
| » W: Bart Johnson (2-4) L: Nolan Ryan (3-4) | Fifth | 7 out |
| Wednesday, May 19 |
| » Defeated Twins (16-14), 4-1 | Comiskey Park I (4-5) | 11-16 | Won 2 |
| » W: Pete Vuckovich (1-1) L: Bert Blyleven (3-3) S: Dave Hamilton (2) | Fifth | 7 out |
| Thursday, May 20 |
| » Defeated Twins (16-15), 3-2 | Comiskey Park I (5-5) | 12-16 | Won 3 |
| » W: Rich Gossage (2-3) L: Pete Redfern (1-1) | Fifth | 7 out |
| Friday, May 21 |
| » Defeated Athletics (15-20), 6-0 | Comiskey Park I (6-5) | 13-16 | Won 4 |
| » W: Ken Brett (1-0) L: Vida Blue (3-5) S: Clay Carroll (3) | Fourth | 7 out |
| Future White Sox Rocky Biddle is born in Las Vegas, NV. |
| Saturday, May 22 |
| » Defeated Athletics (15-21), 7-2 | Comiskey Park I (7-5) | 14-16 | Won 5 |
| » W: Jesse Jefferson (1-1) L: Mike Norris (0-2) | Fourth | 6 out |
| Sunday, May 23 |
| » Defeated Athletics (15-22), 3-1 | Comiskey Park I (8-5) | 15-16 | Won 6 |
| » W: Clay Carroll (2-1) L: Mike Torrez (4-5) | Fourth | 4½ out |
| » Defeated Athletics (15-23), 4-3 | Comiskey Park I (9-5) | 16-16 | Won 7 |
| » W: Bart Johnson (3-4) L: Stan Bahnsen (1-1) S: Clay Carroll (4) | Fourth | 4½ out |
| Monday, May 24 |
| » Defeated Angels (15-26), 5-3 | Anaheim Stadium (1-0) | 17-16 | Won 8 |
| » W: Pete Vuckovich (2-1) L: Jim Brewer (3-1) | Third | 4½ out |
| Tuesday, May 25 |
| » Defeated Angels (15-27), 7-1 | Anaheim Stadium (2-0) | 18-16 | Won 9 |
| » W: Rich Gossage (3-3) L: Gary Ross (1-6) | Third | 4 out |
| Wednesday, May 26 |
| » Defeated Angels (15-28), 1-0 | Anaheim Stadium (3-0) | 19-16 | Won 10 |
| » W: Ken Brett (2-0) L: Don Kirkwood (1-5) S: Clay Carroll (5) | Third | 4 out |
| Thursday, May 27 |
| » Lost to Angels (16-28), 5-3 | Anaheim Stadium (3-1) | 19-17 | |
| » W: Frank Tanana (6-3) L: Francisco Barrios (0-1) | Third | 3½ out |
| Friday, May 28 |
| » Lost to Athletics (19-24), 11-0 | Oakland-Alameda County Stadium (0-1) | 19-18 | Lost 2 |
| » W: Stan Bahnsen (2-1) L: Bart Johnson (3-5) | Third | 4½ out |
| Saturday, May 29 |
| » Lost to Athletics (20-24), 2-0 | Oakland-Alameda County Stadium (0-2) | 19-19 | Lost 3 |
| » W: Vida Blue (5-5) L: Terry Forster (1-2) | Second | 4 out |
| Sunday, May 30 |
| » Defeated Athletics (20-25), 4-3 | Oakland-Alameda County Stadium (1-2) | 20-19 | |
| » W: Clay Carroll (3-1) L: Rollie Fingers (2-4) S: Dave Hamilton (3) | Third | 4 out |
| Monday, May 31 |
| » Defeated Rangers (24-18), 9-4 | Comiskey Park I (10-5) | 21-19 | Won 2 |
| » W: Pete Vuckovich (3-1) L: Nelson Briles (4-2) | Third | 3 out |
| Tuesday, June 1 |
| » Lost to Rangers (25-18), 6-5 | Comiskey Park I (10-6) | 21-20 | |
| » W: Steve Foucault (5-2) L: Jesse Jefferson (1-2) | Third | 4 out |
| Wednesday, June 2 |
| » Defeated Rangers (25-19), 1-0 | Comiskey Park I (11-6) | 22-20 | |
| » W: Dave Hamilton (2-2) L: Jim Umbarger (5-4) | Third | 4 out |
| Friday, June 4 |
| » Defeated Indians (21-23), 4-1 | Comiskey Park I (12-6) | 23-20 | Won 2 |
| » W: Rich Gossage (4-3) L: Dennis Eckersley (3-4) | Third | 4 out |
| Saturday, June 5 |
| » Lost to Indians (22-23), 5-3 | Comiskey Park I (12-7) | 23-21 | |
| » W: Jim Kern (4-2) L: Clay Carroll (3-2) | Third | 5½ out |
| Sunday, June 6 |
| » Defeated Indians (22-24), 3-2 | Comiskey Park I (13-7) | 24-21 | |
| » W: Pete Vuckovich (4-1) L: Jackie Brown (5-2) S: Francisco Barrios (1) | Third | 4 out |
| » Defeated Indians (22-25), 5-0 | Comiskey Park I (14-7) | 25-21 | Won 2 |
| » W: Ken Brett (3-0) L: Don Hood (1-4) | Third | 4 out |
| Tuesday, June 8 |
| » Lost to Brewers (19-26), 2-0 | County Stadium (0-1) | 25-22 | |
| » W: Bill Travers (7-2) L: Bart Johnson (3-6) | Third | 4½ out |
| Wednesday, June 9 |
| » Defeated Brewers (19-27), 4-2 | County Stadium (1-1) | 26-22 | |
| » W: Rich Gossage (5-3) L: Jim Slaton (7-3) S: Clay Carroll (6) | Third | 4½ out |
| Thursday, June 10 |
| » Defeated Brewers (19-28), 12-5 | County Stadium (2-1) | 27-22 | Won 2 |
| » W: Francisco Barrios (1-1) L: Jerry Augustine (1-2) | Third | 4½ out |
| Friday, June 11 |
| » Lost to Indians (24-27), 5-4 | Cleveland Stadium (0-1) | 27-23 | |
| » W: Jim Kern (5-2) L: Terry Forster (1-3) | Third | 5½ out |
| Saturday, June 12 |
| » Lost to Indians (25-27), 3-0 | Cleveland Stadium (0-2) | 27-24 | Lost 2 |
| » W: Rick Waits (1-1) L: Pete Vuckovich (4-2) S: Jim Bibby (1) | Third | 6½ out |
| Sunday, June 13 |
| » Lost to Indians (26-27), 8-5 | Cleveland Stadium (0-3) | 27-25 | Lost 3 |
| » W: Pat Dobson (7-5) L: Bart Johnson (3-7) S: Dave LaRoche (6) | Third | 8 out |
| » Lost to Indians (27-27), 9-7 | Cleveland Stadium (0-4) | 27-26 | Lost 4 |
| » W: Jim Kern (6-2) L: Clay Carroll (3-3) S: Dave LaRoche (7) | Third | 8 out |
| Tuesday, June 15 |
| » Lost to Orioles (25-31), 4-0 | Comiskey Park I (14-8) | 27-27 | Lost 5 |
| » W: Jim Palmer (7-7) L: Rich Gossage (5-4) | Third | 9½ out |
| Former White Sox Jimmy Dykes dies in Philadelphia, PA at the age of 80. |
| Wednesday, June 16 |
| » Lost to Orioles (26-31), 10-2 | Comiskey Park I (14-9) | 27-28 | Lost 6 |
| » W: Mike Cuellar (3-7) L: Francisco Barrios (1-2) | Third | 9½ out |
| » Major-league debuts: Kevin Bell (White Sox) |
| Former White Sox George Dickey dies in DeWitt, AR at the age of 61. |
| Thursday, June 17 |
| » Lost to Yankees (34-22), 5-4 | Comiskey Park I (14-10) | 27-29 | Lost 7 |
| » W: Catfish Hunter (8-6) L: Terry Forster (1-4) S: Sparky Lyle (10) | Fourth | 10 out |
| Friday, June 18 |
| » Lost to Yankees (35-22), 3-2 | Comiskey Park I (14-11) | 27-30 | Lost 8 |
| » W: Grant Jackson (2-1) L: Dave Hamilton (2-3) | Fourth | 11 out |
| Saturday, June 19 |
| » Lost to Yankees (36-22), 4-3 | Comiskey Park I (14-12) | 27-31 | Lost 9 |
| » W: Doyle Alexander (4-4) L: Rich Gossage (5-5) S: Sparky Lyle (11) | Fifth | 11 out |
| Sunday, June 20 |
| » Lost to Yankees (37-22), 6-3 | Comiskey Park I (14-13) | 27-32 | Lost 10 |
| » W: Dock Ellis (7-4) L: Ken Brett (3-1) S: Sparky Lyle (12) | Fifth | 11 out |
| Future White Sox Carlos Lee is born in Aguadulce, Panama. |
| Monday, June 21 |
| » Defeated Royals (39-23), 2-1 | Royals Stadium (2-3) | 28-32 | |
| » W: Dave Hamilton (3-3) L: Tom Hall (2-2) | Fifth | 10 out |
| Tuesday, June 22 |
| » Defeated Royals (39-24), 14-8 | Royals Stadium (3-3) | 29-32 | Won 2 |
| » W: Jesse Jefferson (2-2) L: Steve Busby (3-2) | Fifth | 9 out |
| Wednesday, June 23 |
| » Defeated Twins (30-34), 4-3 | Metropolitan Stadium (2-1) | 30-32 | Won 3 |
| » W: Bart Johnson (4-7) L: Joe Decker (2-7) S: Terry Forster (1) | Fourth | 7½ out |
| » Defeated Twins (30-35), 9-5 | Metropolitan Stadium (3-1) | 31-32 | Won 4 |
| » W: Pete Vuckovich (5-2) L: Pete Redfern (2-4) S: Ken Brett (2) | Fourth | 7½ out |
| Thursday, June 24 |
| » Lost to Twins (31-35), 4-2 | Metropolitan Stadium (3-2) | 31-33 | |
| » W: Bill Singer (6-3) L: Rich Gossage (5-6) | Fourth | 7½ out |
| Friday, June 25 |
| » Lost to Rangers (37-27), 8-4 | Arlington Stadium (1-2) | 31-34 | Lost 2 |
| » W: Gaylord Perry (8-5) L: Dave Hamilton (3-4) | Fourth | 8 out |
| » Defeated Rangers (37-28), 14-9 | Arlington Stadium (2-2) | 32-34 | |
| » W: Pete Vuckovich (6-2) L: Steve Foucault (6-4) | Fourth | 8 out |
| Saturday, June 26 |
| » Lost to Rangers (38-28), 1-0 | Arlington Stadium (2-3) | 32-35 | |
| » W: Bert Blyleven (6-8) L: Ken Brett (3-2) | Fourth | 9 out |
| Sunday, June 27 |
| » Defeated Rangers (38-29), 6-2 | Arlington Stadium (3-3) | 33-35 | |
| » W: Bart Johnson (5-7) L: Nelson Briles (6-5) S: Dave Hamilton (4) | Fourth | 9 out |
| Tuesday, June 29 |
| » Lost to Angels (30-45), 4-1 | Comiskey Park I (14-14) | 33-36 | |
| » W: Frank Tanana (9-5) L: Francisco Barrios (1-3) | Fourth | 9½ out |
| Wednesday, June 30 |
| » Lost to Angels (31-45), 2-1 | Comiskey Park I (14-15) | 33-37 | Lost 2 |
| » W: Dick Drago (2-6) L: Clay Carroll (3-4) | Fourth | 10½ out |
| Thursday, July 1 |
| » Lost to Angels (32-45), 2-1 | Comiskey Park I (14-16) | 33-38 | Lost 3 |
| » W: Sid Monge (4-2) L: Ken Brett (3-3) S: Mickey Scott (2) | Fourth | 10½ out |
| Friday, July 2 |
| » Defeated Rangers (40-31), 1-0 | Comiskey Park I (15-16) | 34-38 | |
| » W: Bart Johnson (6-7) L: Bert Blyleven (6-9) | Fourth | 10½ out |
| Saturday, July 3 |
| » Lost to Rangers (41-31), 3-0 | Comiskey Park I (15-17) | 34-39 | |
| » W: Nelson Briles (7-5) L: Terry Forster (1-5) | Fifth | 11½ out |
| Sunday, July 4 |
| » Defeated Rangers (41-32), 7-6 | Comiskey Park I (16-17) | 35-39 | |
| » W: Dave Hamilton (4-4) L: Mike Bacsik (0-1) | Fifth | 11 out |
| » Lost to Rangers (42-32), 3-2 | Comiskey Park I (16-18) | 35-40 | |
| » W: Steve Hargan (3-2) L: Chris Knapp (0-1) S: Joe Hoerner (6) | Fifth | 11 out |
| Monday, July 5 |
| » Lost to Red Sox (37-37), 11-2 | Fenway Park (2-2) | 35-41 | Lost 2 |
| » W: Luis Tiant (10-5) L: Jesse Jefferson (2-3) | Fifth | 12 out |
| Tuesday, July 6 |
| » Lost to Red Sox (38-37), 4-0 | Fenway Park (2-3) | 35-42 | Lost 3 |
| » W: Fergie Jenkins (7-8) L: Ken Brett (3-4) | Fifth | 12½ out |
| Wednesday, July 7 |
| » Defeated Red Sox (38-38), 6-3 | Fenway Park (3-3) | 36-42 | |
| » W: Bart Johnson (7-7) L: Jim Willoughby (2-5) S: Dave Hamilton (5) | Fifth | 12½ out |
| Thursday, July 8 |
| » Lost to Yankees (48-30), 6-0 | Yankee Stadium (0-3) | 36-43 | |
| » W: Ken Holtzman (7-6) L: Rich Gossage (5-7) | Fifth | 13 out |
| Friday, July 9 |
| » Lost to Yankees (49-30), 2-1 | Yankee Stadium (0-4) | 36-44 | Lost 2 |
| » W: Dock Ellis (10-4) L: Terry Forster (1-6) S: Sparky Lyle (17) | Fifth | 14 out |
| Saturday, July 10 |
| » Defeated Yankees (49-31), 4-1 | Yankee Stadium (1-4) | 37-44 | |
| » W: Ken Brett (4-4) L: Doyle Alexander (4-6) | Fifth | 14 out |
| » Major-league debuts: Juan Bernhardt (Yankees) |
| Sunday, July 11 |
| » Lost to Yankees (50-31), 5-0 | Yankee Stadium (1-5) | 37-45 | |
| » W: Ed Figueroa (10-6) L: Bart Johnson (7-8) | Fifth | 14 out |
| Thursday, July 15 |
| » Defeated Brewers (34-45), 5-3 | Comiskey Park I (17-18) | 38-45 | |
| » W: Ken Brett (5-4) L: Jim Slaton (10-7) | Fifth | 13½ out |
| Friday, July 16 |
| » Defeated Brewers (34-46), 5-2 | Comiskey Park I (18-18) | 39-45 | Won 2 |
| » W: Bart Johnson (8-8) L: Jerry Augustine (2-7) S: Dave Hamilton (6) | Fifth | 14 out |
| » Major-league debuts: Wayne Nordhagen (White Sox) |
| Saturday, July 17 |
| » Lost to Brewers (35-46), 9-2 | Comiskey Park I (18-19) | 39-46 | |
| » W: Jim Colborn (6-10) L: Rich Gossage (5-8) | Fifth | 15 out |
| Sunday, July 18 |
| » Defeated Brewers (35-47), 13-3 | Comiskey Park I (19-19) | 40-46 | |
| » W: Francisco Barrios (2-3) L: Bill Travers (10-7) | Fourth | 15 out |
| Monday, July 19 |
| » Lost to Yankees (55-32), 3-2 | Comiskey Park I (19-20) | 40-47 | |
| » W: Ed Figueroa (12-6) L: Dave Hamilton (4-5) S: Sparky Lyle (18) | Fifth | 15 out |
| Tuesday, July 20 |
| » Lost to Yankees (56-32), 14-9 | Comiskey Park I (19-21) | 40-48 | Lost 2 |
| » W: Jim York (1-0) L: Pete Vuckovich (6-3) | Fifth | 15 out |
| Wednesday, July 21 |
| » Defeated Tigers (41-45), 4-1 | Comiskey Park I (20-21) | 41-48 | |
| » W: Chris Knapp (1-1) L: Vern Ruhle (5-7) | Fourth | 13½ out |
| » Defeated Tigers (41-46), 3-0 | Comiskey Park I (21-21) | 42-48 | Won 2 |
| » W: Bart Johnson (9-8) L: Dave Lemanczyk (1-2) | Fourth | 13½ out |
| Thursday, July 22 |
| » Defeated Tigers (41-47), 9-3 | Comiskey Park I (22-21) | 43-48 | Won 3 |
| » W: Blue Moon Odom (1-0) L: Frank MacCormack (0-5) | Fifth | 14 out |
| » Lost to Tigers (42-47), 5-1 | Comiskey Park I (22-22) | 43-49 | |
| » W: Ray Bare (4-5) L: Rich Gossage (5-9) S: John Hiller (8) | Fifth | 14 out |
| Friday, July 23 |
| » Lost to Twins (44-48), 6-2 | Comiskey Park I (22-23) | 43-50 | Lost 2 |
| » W: Tom Burgmeier (4-0) L: Francisco Barrios (2-4) | Fifth | 14 out |
| Saturday, July 24 |
| » Lost to Twins (45-48), 17-2 | Comiskey Park I (22-24) | 43-51 | Lost 3 |
| » W: Eddie Bane (3-2) L: Jesse Jefferson (2-4) | Fifth | 15 out |
| Sunday, July 25 |
| » Lost to Twins (46-48), 13-8 | Comiskey Park I (22-25) | 43-52 | Lost 4 |
| » W: Vic Albury (3-1) L: Terry Forster (1-7) | Fifth | 14½ out |
| » Defeated Twins (46-49), 7-4 | Comiskey Park I (23-25) | 44-52 | |
| » W: Ken Brett (6-4) L: Bill Singer (8-7) | Fifth | 14½ out |
| Monday, July 26 |
| » Lost to Athletics (52-46), 3-1 | Oakland-Alameda County Stadium (1-3) | 44-53 | |
| » W: Paul Mitchell (7-5) L: Bart Johnson (9-9) S: Rollie Fingers (14) | Fifth | 15½ out |
| Tuesday, July 27 |
| » Lost to Athletics (53-46), 1-0 | Oakland-Alameda County Stadium (1-4) | 44-54 | Lost 2 |
| » W: Vida Blue (9-9) L: Rich Gossage (5-10) | Fifth | 15½ out |
| Wednesday, July 28 |
| » Defeated Athletics (53-47), 2-1 | Oakland-Alameda County Stadium (2-4) | 45-54 | |
| » W: Blue Moon Odom (2-0) L: Paul Lindblad (4-3) S: Francisco Barrios (2) | Fifth | 15½ out |
| Friday, July 30 |
| » Lost to Angels (44-59), 3-0 | Anaheim Stadium (3-2) | 45-55 | |
| » W: Nolan Ryan (8-13) L: Ken Brett (6-5) | Fifth | 16½ out |
| Saturday, July 31 |
| » Lost to Angels (45-59), 3-2 | Anaheim Stadium (3-3) | 45-56 | Lost 2 |
| » W: Dick Drago (5-7) L: Terry Forster (1-8) | Fifth | 16½ out |
| Sunday, August 1 |
| » Defeated Angels (45-60), 2-1 | Anaheim Stadium (4-3) | 46-56 | |
| » W: Rich Gossage (6-10) L: Frank Tanana (12-8) | Fifth | 15½ out |
| Tuesday, August 3 |
| » Lost to Athletics (54-52), 7-3 | Comiskey Park I (23-26) | 46-57 | |
| » W: Dick Bosman (4-0) L: Blue Moon Odom (2-1) S: Rollie Fingers (15) | Fifth | 16½ out |
| Wednesday, August 4 |
| » Lost to Athletics (55-52), 5-0 | Comiskey Park I (23-27) | 46-58 | Lost 2 |
| » W: Paul Mitchell (8-5) L: Ken Brett (6-6) | Fifth | 17½ out |
| Friday, August 6 |
| » Lost to Royals (65-40), 9-2 | Comiskey Park I (23-28) | 46-59 | Lost 3 |
| » W: Andy Hassler (1-7) L: Bart Johnson (9-10) | Sixth | 20 out |
| » Lost to Royals (66-40), 8-3 | Comiskey Park I (23-29) | 46-60 | Lost 4 |
| » W: Doug Bird (10-4) L: Rich Gossage (6-11) | Sixth | 20 out |
| Saturday, August 7 |
| » Defeated Royals (66-41), 5-3 | Comiskey Park I (24-29) | 47-60 | |
| » W: Francisco Barrios (3-4) L: Steve Mingori (3-2) | Fifth | 19 out |
| Sunday, August 8 |
| » Defeated Royals (66-42), 5-2 | Comiskey Park I (25-29) | 48-60 | Won 2 |
| » W: Terry Forster (2-8) L: Marty Pattin (4-10) S: Rich Gossage (1) | Fifth | 19 out |
| » Lost to Royals (67-42), 7-1 | Comiskey Park I (25-30) | 48-61 | |
| » W: Al Fitzmorris (14-7) L: Jesse Jefferson (2-5) | Fifth | 19 out |
| Monday, August 9 |
| » Lost to Indians (53-56), 4-2 | Cleveland Stadium (0-5) | 48-62 | Lost 2 |
| » W: Jim Bibby (8-4) L: Ken Brett (6-7) S: Dave LaRoche (12) | Fifth | 20 out |
| Wednesday, August 11 |
| » Lost to Indians (54-56), 4-3 | Cleveland Stadium (0-6) | 48-63 | Lost 3 |
| » W: Jim Kern (8-5) L: Francisco Barrios (3-5) | Sixth | 19½ out |
| Friday, August 13 |
| » Defeated Orioles (56-54), 5-2 | Memorial Stadium (2-1) | 49-63 | |
| » W: Rich Gossage (7-11) L: Rudy May (8-9) S: Dave Hamilton (7) | Fifth | 18½ out |
| Saturday, August 14 |
| » Lost to Orioles (57-54), 8-6 | Memorial Stadium (2-2) | 49-64 | |
| » W: Jim Palmer (16-10) L: Terry Forster (2-9) S: Fred Holdsworth (2) | Fifth | 20 out |
| » Lost to Orioles (58-54), 6-5 | Memorial Stadium (2-3) | 49-65 | Lost 2 |
| » W: Dyar Miller (2-2) L: Ken Brett (6-8) S: Tippy Martinez (7) | Fifth | 20 out |
| Sunday, August 15 |
| » Lost to Orioles (59-54), 3-0 | Memorial Stadium (2-4) | 49-66 | Lost 3 |
| » W: Wayne Garland (14-3) L: Francisco Barrios (3-6) | Fifth | 21 out |
| Monday, August 16 |
| » Lost to Red Sox (54-60), 12-5 | Comiskey Park I (25-31) | 49-67 | Lost 4 |
| » W: Luis Tiant (13-10) L: Bart Johnson (9-11) S: Bill Lee (3) | Sixth | 22 out |
| Tuesday, August 17 |
| » Defeated Red Sox (54-61), 2-1 | Comiskey Park I (26-31) | 50-67 | |
| » W: Clay Carroll (4-4) L: Tom Murphy (3-6) | Fifth | 22½ out |
| » Lost to Red Sox (55-61), 11-7 | Comiskey Park I (26-32) | 50-68 | |
| » W: Dick Pole (5-5) L: Blue Moon Odom (2-2) | Fifth | 22½ out |
| Wednesday, August 18 |
| » Defeated Red Sox (55-62), 4-2 | Comiskey Park I (27-32) | 51-68 | |
| » W: Rich Gossage (8-11) L: Fergie Jenkins (11-11) | Fifth | 21½ out |
| Thursday, August 19 |
| » Defeated Red Sox (55-63), 4-2 | Comiskey Park I (28-32) | 52-68 | Won 2 |
| » W: Ken Brett (7-8) L: Rick Wise (9-10) | Fifth | 20½ out |
| Friday, August 20 |
| » Lost to Orioles (62-56), 6-4 | Comiskey Park I (28-33) | 52-69 | |
| » W: Wayne Garland (15-3) L: Francisco Barrios (3-7) | Fifth | 21½ out |
| Saturday, August 21 |
| » Defeated Orioles (62-57), 11-10 | Comiskey Park I (29-33) | 53-69 | |
| » W: Dave Hamilton (5-5) L: Mike Cuellar (4-13) | Fifth | 21½ out |
| Sunday, August 22 |
| » Lost to Orioles (63-57), 6-2 | Comiskey Park I (29-34) | 53-70 | |
| » W: Jim Palmer (17-11) L: Ken Kravec (0-1) | Fifth | 22 out |
| » Defeated Orioles (63-58), 7-3 | Comiskey Park I (30-34) | 54-70 | |
| » W: Pete Vuckovich (7-3) L: Ross Grimsley (6-6) S: Francisco Barrios (3) | Fifth | 22 out |
| Monday, August 23 |
| » Lost to Tigers (59-64), 5-4 | Tiger Stadium (1-3) | 54-71 | |
| » W: Ray Bare (6-6) L: Rich Gossage (8-12) | Fifth | 22 out |
| Tuesday, August 24 |
| » Defeated Tigers (59-65), 12-7 | Tiger Stadium (2-3) | 55-71 | |
| » W: Dave Hamilton (6-5) L: Jim Crawford (0-5) | Fifth | 21 out |
| Wednesday, August 25 |
| » Lost to Tigers (60-65), 3-1 | Tiger Stadium (2-4) | 55-72 | |
| » W: Mark Fidrych (15-5) L: Bart Johnson (9-12) | Fifth | 22 out |
| Friday, August 27 |
| » Defeated Brewers (56-66), 5-2 | County Stadium (3-1) | 56-72 | |
| » W: Ken Kravec (1-1) L: Jim Slaton (13-11) S: Dave Hamilton (8) | Fifth | 21½ out |
| Saturday, August 28 |
| » Lost to Brewers (57-66), 10-8 | County Stadium (3-2) | 56-73 | |
| » W: Jim Colborn (8-13) L: Rich Gossage (8-13) | Fifth | 22½ out |
| Former White Sox Bill Hunnefield dies in Nantucket, MA at the age of 78. |
| Sunday, August 29 |
| » Defeated Brewers (57-67), 2-0 | County Stadium (4-2) | 57-73 | |
| » W: Ken Brett (8-8) L: Eduardo Rodriguez (5-10) S: Dave Hamilton (9) | Fifth | 21½ out |
| Tuesday, August 31 |
| » Lost to Indians (66-63), 4-2 | Comiskey Park I (30-35) | 57-74 | |
| » W: Jim Kern (9-7) L: Dave Hamilton (6-6) S: Dave LaRoche (15) | Sixth | 21 out |
| Wednesday, September 1 |
| » Lost to Indians (67-63), 3-0 | Comiskey Park I (30-36) | 57-75 | Lost 2 |
| » W: Jim Bibby (10-5) L: Ken Kravec (1-2) | Sixth | 21 out |
| Friday, September 3 |
| » Lost to Twins (67-69), 11-1 | Metropolitan Stadium (3-3) | 57-76 | Lost 3 |
| » W: Pete Redfern (4-7) L: Rich Gossage (8-14) S: Tom Burgmeier (1) | Sixth | 21 out |
| Saturday, September 4 |
| » Defeated Twins (67-70), 4-0 | Metropolitan Stadium (4-3) | 58-76 | |
| » W: Ken Brett (9-8) L: Jim Hughes (7-12) | Sixth | 21 out |
| Sunday, September 5 |
| » Lost to Twins (68-70), 18-1 | Metropolitan Stadium (4-4) | 58-77 | |
| » W: Tom Johnson (3-1) L: Bart Johnson (9-13) | Sixth | 21 out |
| Monday, September 6 |
| » Lost to Twins (69-70), 3-2 | Metropolitan Stadium (4-5) | 58-78 | Lost 2 |
| » W: Bill Campbell (15-4) L: Francisco Barrios (3-8) | Sixth | 21 out |
| Tuesday, September 7 |
| » Lost to Athletics (74-63), 4-0 | Oakland-Alameda County Stadium (2-5) | 58-79 | Lost 3 |
| » W: Mike Torrez (12-10) L: Terry Forster (2-10) | Sixth | 21 out |
| Wednesday, September 8 |
| » Defeated Athletics (74-64), 6-5 | Oakland-Alameda County Stadium (3-5) | 59-79 | |
| » W: Chris Knapp (2-1) L: Rollie Fingers (11-10) | Sixth | 20 out |
| Thursday, September 9 |
| » Lost to Athletics (75-64), 2-1 | Oakland-Alameda County Stadium (3-6) | 59-80 | |
| » W: Jim Todd (7-8) L: Ken Brett (9-9) S: Rollie Fingers (20) | Sixth | 21 out |
| Friday, September 10 |
| » Lost to Angels (64-77), 3-2 | Comiskey Park I (30-37) | 59-81 | Lost 2 |
| » W: Nolan Ryan (13-17) L: Bart Johnson (9-14) | Sixth | 21 out |
| Saturday, September 11 |
| » Lost to Angels (65-77), 7-3 | Comiskey Park I (30-38) | 59-82 | Lost 3 |
| » W: Frank Tanana (16-9) L: Ken Kravec (1-3) S: Dick Drago (5) | Sixth | 22 out |
| Sunday, September 12 |
| » Defeated Angels (65-78), 2-1 | Comiskey Park I (31-38) | 60-82 | |
| » W: Rich Gossage (9-14) L: Sid Monge (5-6) | Sixth | 21½ out |
| » Defeated Angels (65-79), 5-1 | Comiskey Park I (32-38) | 61-82 | Won 2 |
| » W: Francisco Barrios (4-8) L: Don Kirkwood (6-11) | Sixth | 21½ out |
| Monday, September 13 |
| » Defeated Royals (82-61), 4-3 | Comiskey Park I (33-38) | 62-82 | Won 3 |
| » W: Chris Knapp (3-1) L: Dennis Leonard (16-8) S: Dave Hamilton (10) | Sixth | 19½ out |
| » Defeated Royals (82-62), 5-4 | Comiskey Park I (34-38) | 63-82 | Won 4 |
| » W: Ken Brett (10-9) L: Steve Mingori (4-5) | Sixth | 19½ out |
| Tuesday, September 14 |
| » Lost to Royals (83-62), 2-1 | Comiskey Park I (34-39) | 63-83 | |
| » W: Andy Hassler (5-10) L: Terry Forster (2-11) | Sixth | 20½ out |
| Wednesday, September 15 |
| » Lost to Rangers (65-80), 4-3 | Comiskey Park I (34-40) | 63-84 | Lost 2 |
| » W: Bert Blyleven (12-15) L: Bart Johnson (9-15) | Sixth | 20½ out |
| Thursday, September 16 |
| » Lost to Rangers (66-80), 5-4 | Comiskey Park I (34-41) | 63-85 | Lost 3 |
| » W: Nelson Briles (10-9) L: Ken Kravec (1-4) S: Joe Hoerner (8) | Sixth | 21½ out |
| Friday, September 17 |
| » Lost to Royals (85-63), 3-2 | Royals Stadium (3-4) | 63-86 | Lost 4 |
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