| Tuesday, February 10 |
| Future Astro Lance Berkman is born in Waco, TX. |
| Monday, February 23 |
| Future Astro Scott Elarton is born in Lamar, CO. |
| Thursday, April 8 |
| » Lost to Reds (1-0), 11-5 | Riverfront Stadium (0-1) | 0-1 | |
| » W: Gary Nolan (1-0) L: J.R. Richard (0-1) S: Pedro Borbon (1) | Third | 1 out |
| » Major-league debuts: Joaquin Andujar (Astros) |
| Saturday, April 10 |
| » Lost to Reds (2-0), 13-7 | Riverfront Stadium (0-2) | 0-2 | Lost 2 |
| » W: Jack Billingham (1-0) L: Larry Dierker (0-1) S: Rawly Eastwick (1) | Fifth | 2 out |
| » Major-league debuts: Santo Alcala (Reds) |
| Sunday, April 11 |
| » Lost to Reds (3-0), 9-3 | Riverfront Stadium (0-3) | 0-3 | Lost 3 |
| » W: Pat Darcy (1-0) L: Joe Niekro (0-1) | Sixth | 3 out |
| » Major-league debuts: Pat Zachry (Reds) |
| Monday, April 12 |
| » Defeated Giants (2-1), 5-0 | Astrodome (1-0) | 1-3 | |
| » W: J.R. Richard (1-1) L: Ed Halicki (0-1) S: Ken Forsch (1) | Fourth | 2½ out |
| Tuesday, April 13 |
| » Defeated Giants (2-2), 2-1 | Astrodome (2-0) | 2-3 | Won 2 |
| » W: Mike Barlow (1-0) L: John Montefusco (1-1) S: Ken Forsch (2) | Third | 2½ out |
| Wednesday, April 14 |
| » Defeated Giants (2-3), 5-3 | Astrodome (3-0) | 3-3 | Won 3 |
| » W: Larry Dierker (1-1) L: Mike Caldwell (0-1) S: Larry Hardy (1) | Fourth | 2 out |
| Friday, April 16 |
| » Defeated Padres (3-3), 4-1 | Astrodome (4-0) | 4-3 | Won 4 |
| » W: Joe Niekro (1-1) L: Dave Wehrmeister (0-1) S: Ken Forsch (3) | Second | ½ out |
| » Major-league debuts: Dave Wehrmeister (Padres) |
| Saturday, April 17 |
| » Defeated Padres (3-4), 5-4 | Astrodome (5-0) | 5-3 | Won 5 |
| » W: J.R. Richard (2-1) L: Dan Spillner (0-2) S: Ken Forsch (4) | Second | ½ out |
| Sunday, April 18 |
| » Defeated Padres (3-5), 4-2 | Astrodome (6-0) | 6-3 | Won 6 |
| » W: Tom Griffin (1-0) L: Brent Strom (1-1) S: Ken Forsch (5) | Second | 1 out |
| » Lost to Padres (4-5), 11-5 | Astrodome (6-1) | 6-4 | |
| » W: Randy Jones (3-0) L: Joaquin Andujar (0-1) | Second | 1 out |
| Monday, April 19 |
| » Defeated Dodgers (1-7), 8-3 | Astrodome (7-1) | 7-4 | |
| » W: Larry Dierker (2-1) L: Don Sutton (0-3) | First | -- |
| Tuesday, April 20 |
| » Lost to Dodgers (2-7), 6-3 | Astrodome (7-2) | 7-5 | |
| » W: Rick Rhoden (1-0) L: Joe Niekro (1-2) S: Mike Marshall (2) | First | -- |
| Wednesday, April 21 |
| » Defeated Dodgers (2-8), 1-0 | Astrodome (8-2) | 8-5 | |
| » W: Mike Barlow (2-0) L: Stan Wall (0-1) | First | -- |
| Thursday, April 22 |
| » Lost to Dodgers (3-8), 7-2 | Astrodome (8-3) | 8-6 | |
| » W: Doug Rau (2-0) L: Joaquin Andujar (0-2) S: Mike Marshall (3) | Second | 2 out |
| Friday, April 23 |
| » Defeated Mets (6-7), 3-1 | Astrodome (9-3) | 9-6 | |
| » W: Mike Cosgrove (1-0) L: Jerry Koosman (1-1) S: Ken Forsch (6) | Second | 2 out |
| Saturday, April 24 |
| » Lost to Mets (7-7), 7-1 | Astrodome (9-4) | 9-7 | |
| » W: Tom Seaver (2-0) L: Larry Dierker (2-2) | Second | 2 out |
| Sunday, April 25 |
| » Lost to Mets (8-7), 4-2 | Astrodome (9-5) | 9-8 | Lost 2 |
| » W: Ken Sanders (1-0) L: Joe Niekro (1-3) | Third | 2 out |
| Wednesday, April 28 |
| » Defeated Expos (5-9), 6-4 | Parc Jarry (1-0) | 10-8 | |
| » W: J.R. Richard (3-1) L: Woodie Fryman (2-2) | Second | 1½ out |
| » Lost to Expos (6-9), 8-7 | Parc Jarry (1-1) | 10-9 | |
| » W: Don Carrithers (1-1) L: Mike Barlow (2-1) | Second | 1½ out |
| Thursday, April 29 |
| » Defeated Expos (6-10), 3-1 | Parc Jarry (2-1) | 11-9 | |
| » W: Larry Dierker (3-2) L: Dale Murray (0-2) S: Larry Hardy (2) | Second | 2 out |
| Friday, April 30 |
| » Lost to Mets (13-7), 3-1 | Shea Stadium (0-1) | 11-10 | |
| » W: Jon Matlack (3-0) L: Joe Niekro (1-4) | Third | 2 out |
| Sunday, May 2 |
| » Defeated Mets (13-8), 5-4 | Shea Stadium (1-1) | 12-10 | |
| » W: J.R. Richard (4-1) L: Bob Apodaca (1-1) S: Larry Hardy (3) | Third | 2 out |
| » Lost to Mets (14-8), 7-4 | Shea Stadium (1-2) | 12-11 | |
| » W: Jerry Koosman (2-1) L: Gil Rondon (0-1) S: Skip Lockwood (2) | Third | 2 out |
| Tuesday, May 4 |
| » Lost to Phillies (12-6), 5-0 | Veteran's Stadium (0-1) | 12-12 | Lost 2 |
| » W: Jim Lonborg (3-0) L: Larry Dierker (3-3) | Third | 2 out |
| Wednesday, May 5 |
| » Lost to Phillies (13-6), 6-3 | Veteran's Stadium (0-2) | 12-13 | Lost 3 |
| » W: Ron Reed (2-0) L: Joe Niekro (1-5) S: Gene Garber (3) | Fourth | 3 out |
| Future Astro Keith Ginter is born in Norwalk, CA. |
| Friday, May 7 |
| » Defeated Cardinals (11-13), 3-1 | Busch Stadium II (1-0) | 13-13 | |
| » W: J.R. Richard (5-1) L: Bob Forsch (0-1) | Fourth | 3 out |
| Saturday, May 8 |
| » Lost to Cardinals (12-13), 5-1 | Busch Stadium II (1-1) | 13-14 | |
| » W: Lynn McGlothen (3-3) L: Mike Cosgrove (1-1) | Third | 3 out |
| Sunday, May 9 |
| » Defeated Cardinals (12-14), 10-5 | Busch Stadium II (2-1) | 14-14 | |
| » W: Larry Dierker (4-3) L: John Denny (1-2) | Fourth | 2½ out |
| Tuesday, May 11 |
| » Defeated Expos (9-16), 5-3 | Astrodome (10-5) | 15-14 | Won 2 |
| » W: Tom Griffin (2-0) L: Clay Kirby (0-2) S: Ken Forsch (7) | Third | 2½ out |
| Wednesday, May 12 |
| » Lost to Expos (10-16), 7-2 | Astrodome (10-6) | 15-15 | |
| » W: Woodie Fryman (4-2) L: J.R. Richard (5-2) | Fourth | 3½ out |
| Friday, May 14 |
| » Lost to Phillies (17-8), 5-1 | Astrodome (10-7) | 15-16 | Lost 2 |
| » W: Larry Christenson (3-1) L: Mike Cosgrove (1-2) | Fourth | 4½ out |
| Saturday, May 15 |
| » Lost to Phillies (18-8), 2-1 | Astrodome (10-8) | 15-17 | Lost 3 |
| » W: Jim Lonborg (5-0) L: Larry Dierker (4-4) | Fourth | 4½ out |
| Sunday, May 16 |
| » Lost to Phillies (19-8), 12-2 | Astrodome (10-9) | 15-18 | Lost 4 |
| » W: Steve Carlton (3-1) L: Tom Griffin (2-1) | Fourth | 5½ out |
| Monday, May 17 |
| » Lost to Braves (11-21), 3-2 | Astrodome (10-10) | 15-19 | Lost 5 |
| » W: Andy Messersmith (1-4) L: J.R. Richard (5-3) | Fourth | 5½ out |
| » Defeated Braves (11-22), 3-2 | Astrodome (11-10) | 16-19 | |
| » W: Ken Forsch (1-0) L: Bruce Dal Canton (1-1) | Fourth | 5½ out |
| Tuesday, May 18 |
| » Lost to Braves (12-22), 3-2 | Astrodome (11-11) | 16-20 | |
| » W: Elias Sosa (3-3) L: Mike Barlow (2-2) | Fourth | 6 out |
| Wednesday, May 19 |
| » Defeated Padres (17-16), 9-4 | San Diego/Jack Murphy Stadium (1-0) | 17-20 | |
| » W: Tom Griffin (3-1) L: Dan Spillner (1-6) | Fourth | 6 out |
| Thursday, May 20 |
| » Defeated Padres (17-17), 5-4 | San Diego/Jack Murphy Stadium (2-0) | 18-20 | Won 2 |
| » W: Joe Niekro (2-5) L: Dave Wehrmeister (0-4) S: Ken Forsch (8) | Fourth | 6 out |
| Friday, May 21 |
| » Lost to Dodgers (24-13), 2-1 | Dodger Stadium (0-1) | 18-21 | |
| » W: Burt Hooton (4-2) L: J.R. Richard (5-4) | Fourth | 7 out |
| Saturday, May 22 |
| » Lost to Dodgers (25-13), 6-5 | Dodger Stadium (0-2) | 18-22 | Lost 2 |
| » W: Charlie Hough (5-0) L: Paul Siebert (0-1) | Fourth | 8 out |
| Sunday, May 23 |
| » Lost to Dodgers (26-13), 6-5 | Dodger Stadium (0-3) | 18-23 | Lost 3 |
| » W: Stan Wall (1-1) L: Paul Siebert (0-2) | Fourth | 9 out |
| Monday, May 24 |
| » Lost to Giants (14-27), 5-1 | Candlestick Park (0-1) | 18-24 | Lost 4 |
| » W: Rob Dressler (1-1) L: Mike Cosgrove (1-3) | Fourth | 9 out |
| Tuesday, May 25 |
| » Lost to Giants (15-27), 7-6 | Candlestick Park (0-2) | 18-25 | Lost 5 |
| » W: Dave Heaverlo (2-0) L: Ken Forsch (1-1) | Fourth | 9 out |
| Wednesday, May 26 |
| » Lost to Giants (16-27), 11-4 | Candlestick Park (0-3) | 18-26 | Lost 6 |
| » W: Jim Barr (2-4) L: Larry Dierker (4-5) S: Randy Moffitt (1) | Fourth | 10 out |
| Saturday, May 29 |
| » Defeated Braves (16-27), 4-3 | Atlanta-Fulton County Stadium (1-0) | 19-26 | |
| » W: Joe Niekro (3-5) L: Phil Niekro (3-4) S: Ken Forsch (9) | Fourth | 8½ out |
| Sunday, May 30 |
| » Defeated Braves (16-28), 5-2 | Atlanta-Fulton County Stadium (2-0) | 20-26 | Won 2 |
| » W: Tom Griffin (4-1) L: Andy Messersmith (2-5) S: Ken Forsch (10) | Fourth | 7½ out |
| » Defeated Braves (16-29), 16-5 | Atlanta-Fulton County Stadium (3-0) | 21-26 | Won 3 |
| » W: Gil Rondon (1-1) L: Roger Moret (1-1) S: Gene Pentz (1) | Fourth | 7½ out |
| Monday, May 31 |
| » Lost to Reds (28-17), 4-2 | Astrodome (11-12) | 21-27 | |
| » W: Pat Darcy (2-3) L: J.R. Richard (5-5) S: Rawly Eastwick (6) | Fourth | 8½ out |
| Tuesday, June 1 |
| » Defeated Reds (28-18), 2-1 | Astrodome (12-12) | 22-27 | |
| » W: Joaquin Andujar (1-2) L: Pat Zachry (4-1) | Fourth | 7½ out |
| Wednesday, June 2 |
| » Lost to Reds (29-18), 8-7 | Astrodome (12-13) | 22-28 | |
| » W: Will McEnaney (1-2) L: Ken Forsch (1-2) | Fourth | 8½ out |
| Thursday, June 3 |
| » Defeated Reds (29-19), 5-3 | Astrodome (13-13) | 23-28 | |
| » W: Larry Dierker (5-5) L: Santo Alcala (5-1) S: Ken Forsch (11) | Fourth | 7½ out |
| Friday, June 4 |
| » Defeated Cubs (22-26), 1-0 | Astrodome (14-13) | 24-28 | Won 2 |
| » W: Mike Cosgrove (2-3) L: Rick Reuschel (5-4) | Fourth | 7½ out |
| Saturday, June 5 |
| » Defeated Cubs (22-27), 4-3 | Astrodome (15-13) | 25-28 | Won 3 |
| » W: J.R. Richard (6-5) L: Oscar Zamora (3-1) S: Ken Forsch (12) | Fourth | 7½ out |
| Sunday, June 6 |
| » Defeated Cubs (22-28), 2-0 | Astrodome (16-13) | 26-28 | Won 4 |
| » W: Joaquin Andujar (2-2) L: Bill Bonham (4-3) | Fourth | 7 out |
| » Defeated Cubs (22-29), 5-1 | Astrodome (17-13) | 27-28 | Won 5 |
| » W: Gil Rondon (2-1) L: Ken Frailing (1-2) S: Gene Pentz (2) | Fourth | 7 out |
| Monday, June 7 |
| » Lost to Cardinals (23-29), 7-6 | Astrodome (17-14) | 27-29 | |
| » W: Jack Curtis (4-5) L: Joe Niekro (3-6) S: Al Hrabosky (6) | Fourth | 7 out |
| Tuesday, June 8 |
| » Defeated Cardinals (23-30), 2-0 | Astrodome (18-14) | 28-29 | |
| » W: Larry Dierker (6-5) L: Bob Forsch (1-2) | Fourth | 7 out |
| Wednesday, June 9 |
| » Defeated Cardinals (23-31), 5-2 | Astrodome (19-14) | 29-29 | Won 2 |
| » W: J.R. Richard (7-5) L: Lynn McGlothen (5-5) | Fourth | 7 out |
| Friday, June 11 |
| » Lost to Cubs (24-31), 8-3 | Wrigley Field (0-1) | 29-30 | |
| » W: Bill Bonham (5-3) L: Mike Cosgrove (2-4) S: Paul Reuschel (1) | Fourth | 8½ out |
| Saturday, June 12 |
| » Lost to Cubs (25-31), 5-2 | Wrigley Field (0-2) | 29-31 | Lost 2 |
| » W: Rick Reuschel (6-4) L: Joaquin Andujar (2-3) S: Darold Knowles (6) | Fourth | 8½ out |
| Sunday, June 13 |
| » Lost to Cubs (26-31), 8-3 | Wrigley Field (0-3) | 29-32 | Lost 3 |
| » W: Ray Burris (3-8) L: Larry Dierker (6-6) S: Paul Reuschel (2) | Fourth | 9 out |
| Monday, June 14 |
| » Lost to Pirates (33-25), 2-1 | Astrodome (19-15) | 29-33 | Lost 4 |
| » W: Jerry Reuss (7-5) L: J.R. Richard (7-6) | Fourth | 10 out |
| Wednesday, June 16 |
| » Lost to Pirates (34-25), 6-3 | Astrodome (19-16) | 29-34 | Lost 5 |
| » W: Doc Medich (5-5) L: Joaquin Andujar (2-4) S: Larry Demery (2) | Fourth | 10½ out |
| Friday, June 18 |
| » Lost to Pirates (35-25), 7-3 | Three Rivers Stadium (0-1) | 29-35 | Lost 6 |
| » W: John Candelaria (6-4) L: J.R. Richard (7-7) | Fourth | 10½ out |
| Sunday, June 20 |
| » Defeated Pirates (35-26), 9-4 | Three Rivers Stadium (1-1) | 30-35 | |
| » W: Tom Griffin (5-1) L: Bob Moose (3-2) | Fourth | 10 out |
| Monday, June 21 |
| » Lost to Braves (28-36), 11-9 | Atlanta-Fulton County Stadium (3-1) | 30-36 | |
| » W: Elias Sosa (4-4) L: Gene Pentz (0-1) | Fourth | 11 out |
| Tuesday, June 22 |
| » Defeated Braves (28-37), 9-7 | Atlanta-Fulton County Stadium (4-1) | 31-36 | |
| » W: Gene Pentz (1-1) L: Frank LaCorte (0-1) S: Ken Forsch (13) | Fourth | 11 out |
| Wednesday, June 23 |
| » Lost to Dodgers (38-31), 1-0 | Astrodome (19-17) | 31-37 | |
| » W: Rick Rhoden (6-0) L: J.R. Richard (7-8) | Fourth | 11 out |
| Thursday, June 24 |
| » Lost to Dodgers (39-31), 5-1 | Astrodome (19-18) | 31-38 | Lost 2 |
| » W: Tommy John (4-4) L: Larry Dierker (6-7) S: Charlie Hough (6) | Fifth | 11 out |
| Friday, June 25 |
| » Lost to Reds (43-27), 8-6 | Astrodome (19-19) | 31-39 | Lost 3 |
| » W: Pedro Borbon (1-1) L: Tom Griffin (5-2) S: Will McEnaney (4) | Fifth | 12 out |
| Saturday, June 26 |
| » Defeated Reds (43-28), 3-0 | Astrodome (20-19) | 32-39 | |
| » W: Joaquin Andujar (3-4) L: Pat Zachry (6-3) | Fifth | 11 out |
| Sunday, June 27 |
| » Lost to Reds (44-28), 4-2 | Astrodome (20-20) | 32-40 | |
| » W: Fred Norman (6-1) L: J.R. Richard (7-9) S: Rawly Eastwick (9) | Fifth | 12 out |
| Monday, June 28 |
| » Defeated Giants (30-46), 8-2 | Candlestick Park (1-3) | 33-40 | |
| » W: Mike Cosgrove (3-4) L: Rob Dressler (1-6) S: Ken Forsch (14) | Fourth | 12 out |
| Tuesday, June 29 |
| » Defeated Giants (30-47), 4-3 | Candlestick Park (2-3) | 34-40 | Won 2 |
| » W: Larry Dierker (7-7) L: Jim Barr (6-6) | Fourth | 12 out |
| Wednesday, June 30 |
| » Lost to Giants (31-47), 10-2 | Candlestick Park (2-4) | 34-41 | |
| » W: Ed Halicki (7-10) L: Gil Rondon (2-2) | Fourth | 12 out |
| Friday, July 2 |
| » Defeated Reds (46-30), 10-8 | Riverfront Stadium (1-3) | 35-41 | |
| » W: Gene Pentz (2-1) L: Rich Hinton (0-1) | Fourth | 10 out |
| » Defeated Reds (46-31), 3-2 | Riverfront Stadium (2-3) | 36-41 | Won 2 |
| » W: Joaquin Andujar (4-4) L: Fred Norman (6-2) | Fourth | 10 out |
| Saturday, July 3 |
| » Lost to Reds (47-31), 9-8 | Riverfront Stadium (2-4) | 36-42 | |
| » W: Pedro Borbon (2-1) L: Joe Niekro (3-7) | Fifth | 11 out |
| Sunday, July 4 |
| » Lost to Reds (48-31), 7-2 | Riverfront Stadium (2-5) | 36-43 | Lost 2 |
| » W: Gary Nolan (8-4) L: Larry Dierker (7-8) | Fifth | 12 out |
| Monday, July 5 |
| » Defeated Mets (43-39), 7-3 | Astrodome (21-20) | 37-43 | |
| » W: Joe Niekro (4-7) L: Bob Apodaca (1-4) | Fifth | 12 out |
| Tuesday, July 6 |
| » Defeated Mets (43-40), 1-0 | Astrodome (22-20) | 38-43 | Won 2 |
| » W: J.R. Richard (8-9) L: Skip Lockwood (5-3) | Fifth | 12 out |
| Wednesday, July 7 |
| » Lost to Mets (44-40), 12-4 | Astrodome (22-21) | 38-44 | |
| » W: Jerry Koosman (9-6) L: Joaquin Andujar (4-5) | Fifth | 13 out |
| Thursday, July 8 |
| » Defeated Expos (25-49), 7-6 | Astrodome (23-21) | 39-44 | |
| » W: Ken Forsch (2-2) L: Steve Dunning (0-3) | Fourth | 12½ out |
| Friday, July 9 |
| » Defeated Expos (25-50), 6-0 | Astrodome (24-21) | 40-44 | Won 2 |
| » W: Larry Dierker (8-8) L: Don Stanhouse (6-4) | Fourth | 13 out |
| » Major-league debuts: Joe Kerrigan (Expos) |
| Saturday, July 10 |
| » Defeated Expos (25-51), 4-2 | Astrodome (25-21) | 41-44 | Won 3 |
| » W: J.R. Richard (9-9) L: Clay Kirby (1-7) S: Ken Forsch (15) | Fourth | 12 out |
| Sunday, July 11 |
| » Defeated Expos (25-52), 1-0 | Astrodome (26-21) | 42-44 | Won 4 |
| » W: Joaquin Andujar (5-5) L: Steve Rogers (2-8) | Fourth | 11 out |
| Thursday, July 15 |
| » Lost to Mets (47-42), 3-1 | Shea Stadium (1-3) | 42-45 | |
| » W: Jerry Koosman (10-6) L: J.R. Richard (9-10) | Fourth | 11 out |
| Friday, July 16 |
| » Defeated Mets (47-43), 4-3 | Shea Stadium (2-3) | 43-45 | |
| » W: Larry Dierker (9-8) L: Jon Matlack (10-3) S: Gene Pentz (3) | Third | 11 out |
| Saturday, July 17 |
| » Defeated Mets (47-44), 1-0 | Shea Stadium (3-3) | 44-45 | Won 2 |
| » W: Joaquin Andujar (6-5) L: Tom Seaver (9-6) | Third | 11 out |
| Sunday, July 18 |
| » Defeated Expos (26-55), 7-6 | Parc Jarry (3-1) | 45-45 | Won 3 |
| » W: Ken Forsch (3-2) L: Dale Murray (0-8) | Third | 10½ out |
| » Defeated Expos (26-56), 14-1 | Parc Jarry (4-1) | 46-45 | Won 4 |
| » W: Dan Larson (1-0) L: Steve Dunning (0-4) | Third | 10½ out |
| » Major-league debuts: Dan Larson (Astros) |
| Monday, July 19 |
| » Defeated Expos (26-57), 3-1 | Parc Jarry (5-1) | 47-45 | Won 5 |
| » W: J.R. Richard (10-10) L: Steve Rogers (3-9) | Third | 10½ out |
| Tuesday, July 20 |
| » Lost to Pirates (49-38), 9-5 | Three Rivers Stadium (1-2) | 47-46 | |
| » W: John Candelaria (10-4) L: Tom Griffin (5-3) S: Kent Tekulve (2) | Third | 10 out |
| » Defeated Pirates (49-39), 4-3 | Three Rivers Stadium (2-2) | 48-46 | |
| » W: Ken Forsch (4-2) L: Dave Giusti (0-1) | Third | 10 out |
| » Major-league debuts: Bo McLaughlin and Joe Sambito (Astros) |
| Wednesday, July 21 |
| » Lost to Pirates (50-39), 5-1 | Three Rivers Stadium (2-3) | 48-47 | |
| » W: Jerry Reuss (10-5) L: Larry Dierker (9-9) | Third | 11½ out |
| » Lost to Pirates (51-39), 4-1 | Three Rivers Stadium (2-4) | 48-48 | Lost 2 |
| » W: Larry Demery (6-3) L: Joaquin Andujar (6-6) S: Dave Giusti (4) | Third | 11½ out |
| Friday, July 23 |
| » Lost to Giants (41-55), 3-0 | Astrodome (26-22) | 48-49 | Lost 3 |
| » W: Jim Barr (8-6) L: J.R. Richard (10-11) | Third | 12½ out |
| Saturday, July 24 |
| » Defeated Giants (41-56), 5-4 | Astrodome (27-22) | 49-49 | |
| » W: Gene Pentz (3-1) L: Dave Heaverlo (3-2) | Fourth | 12½ out |
| » Lost to Giants (42-56), 4-0 | Astrodome (27-23) | 49-50 | |
| » W: John D'Acquisto (2-5) L: Dan Larson (1-1) S: Mike Caldwell (1) | Fourth | 12½ out |
| Sunday, July 25 |
| » Defeated Giants (42-57), 1-0 | Astrodome (28-23) | 50-50 | |
| » W: Bo McLaughlin (1-0) L: Ed Halicki (9-13) | Third | 12½ out |
| Monday, July 26 |
| » Defeated Padres (48-51), 7-0 | Astrodome (29-23) | 51-50 | Won 2 |
| » W: Larry Dierker (10-9) L: Dan Spillner (2-10) | Third | 12½ out |
| Tuesday, July 27 |
| » Defeated Padres (48-52), 4-1 | Astrodome (30-23) | 52-50 | Won 3 |
| » W: J.R. Richard (11-11) L: Jerry Johnson (0-1) | Third | 11½ out |
| Wednesday, July 28 |
| » Lost to Padres (49-52), 2-1 | Astrodome (30-24) | 52-51 | |
| » W: Randy Jones (18-4) L: Joaquin Andujar (6-7) | Third | 11½ out |
| Friday, July 30 |
| » Lost to Braves (46-54), 3-2 | Astrodome (30-25) | 52-52 | Lost 2 |
| » W: Andy Messersmith (10-9) L: Dan Larson (1-2) | Third | 13½ out |
| Saturday, July 31 |
| » Defeated Braves (46-55), 2-1 | Astrodome (31-25) | 53-52 | |
| » W: J.R. Richard (12-11) L: Dick Ruthven (11-9) | Third | 13 out |
| » Defeated Braves (46-56), 9-6 | Astrodome (32-25) | 54-52 | Won 2 |
| » W: Joe Sambito (1-0) L: Bruce Dal Canton (3-4) S: Ken Forsch (16) | Third | 13 out |
| Sunday, August 1 |
| » Defeated Braves (46-57), 6-0 | Astrodome (33-25) | 55-52 | Won 3 |
| » W: Larry Dierker (11-9) L: Phil Niekro (11-7) | Third | 13 out |
| Monday, August 2 |
| » Lost to Dodgers (58-46), 5-4 | Dodger Stadium (0-4) | 55-53 | |
| » W: Elias Sosa (5-7) L: Gene Pentz (3-2) | Third | 14 out |
| Tuesday, August 3 |
| » Lost to Dodgers (59-46), 2-0 | Dodger Stadium (0-5) | 55-54 | Lost 2 |
| » W: Burt Hooton (7-11) L: Dan Larson (1-3) | Third | 15 out |
| Wednesday, August 4 |
| » Defeated Dodgers (59-47), 1-0 | Dodger Stadium (1-5) | 56-54 | |
| » W: J.R. Richard (13-11) L: Doug Rau (10-8) | Third | 14 out |
| Future Astro Scott Linebrink is born in Austin, TX. |
| Thursday, August 5 |
| » Lost to Padres (52-59), 4-3 | San Diego/Jack Murphy Stadium (2-1) | 56-55 | |
| » W: Dave Freisleben (7-9) L: Bo McLaughlin (1-1) S: Butch Metzger (9) | Third | 15 out |
| Friday, August 6 |
| » Lost to Padres (53-59), 9-3 | San Diego/Jack Murphy Stadium (2-2) | 56-56 | Lost 2 |
| » W: Tom Griffin (6-3) L: Larry Dierker (11-10) S: Butch Metzger (10) | Third | 16 out |
| Saturday, August 7 |
| » Lost to Padres (54-59), 3-2 | San Diego/Jack Murphy Stadium (2-3) | 56-57 | Lost 3 |
| » W: Rick Sawyer (2-0) L: Joaquin Andujar (6-8) S: Butch Metzger (11) | Third | 17 out |
| Sunday, August 8 |
| » Lost to Padres (55-59), 4-3 | San Diego/Jack Murphy Stadium (2-4) | 56-58 | Lost 4 |
| » W: Butch Metzger (10-0) L: J.R. Richard (13-12) | Third | 18 out |
| Monday, August 9 |
| » Defeated Cardinals (46-62), 13-4 | Busch Stadium II (3-1) | 57-58 | |
| » W: Dan Larson (2-3) L: Bob Forsch (5-7) | Third | 17½ out |
| » Major-league debuts: Garry Templeton (Cardinals) |
| Tuesday, August 10 |
| » Lost to Cardinals (47-62), 8-1 | Busch Stadium II (3-2) | 57-59 | |
| » W: Lynn McGlothen (10-11) L: Bo McLaughlin (1-2) | Third | 17½ out |
| Wednesday, August 11 |
| » Defeated Cardinals (47-63), 8-1 | Busch Stadium II (4-2) | 58-59 | |
| » W: Larry Dierker (12-10) L: John Denny (6-6) | Third | 17½ out |
| Friday, August 13 |
| » Lost to Pirates (61-52), 8-5 | Astrodome (33-26) | 58-60 | |
| » W: Kent Tekulve (4-1) L: Joe Niekro (4-8) | Third | 19 out |
| Saturday, August 14 |
| » Lost to Pirates (62-52), 5-4 | Astrodome (33-27) | 58-61 | Lost 2 |
| » W: Dave Giusti (3-3) L: Gene Pentz (3-3) | Third | 19 out |
| Sunday, August 15 |
| » Lost to Pirates (63-52), 8-6 | Astrodome (33-28) | 58-62 | Lost 3 |
| » W: Doc Medich (6-11) L: Dan Larson (2-4) S: Kent Tekulve (3) | Fourth | 19½ out |
| » Lost to Pirates (64-52), 3-0 | Astrodome (33-29) | 58-63 | Lost 4 |
| » W: Jerry Reuss (11-7) L: Joe Sambito (1-1) | Fourth | 19½ out |
| Monday, August 16 |
| » Lost to Cubs (55-66), 5-3 | Astrodome (33-30) | 58-64 | Lost 5 |
| » W: Bruce Sutter (3-3) L: Larry Dierker (12-11) | Fourth | 19½ out |
| Tuesday, August 17 |
| » Defeated Cubs (55-67), 8-1 | Astrodome (34-30) | 59-64 | |
| » W: J.R. Richard (14-12) L: Steve Stone (3-5) | Fourth | 18½ out |
| Thursday, August 19 |
| » Lost to Phillies (78-40), 7-1 | Veteran's Stadium (0-3) | 59-65 | |
| » W: Steve Carlton (15-4) L: Joaquin Andujar (6-9) | Fourth | 20 out |
| Friday, August 20 |
| » Defeated Phillies (78-41), 8-3 | Veteran's Stadium (1-3) | 60-65 | |
| » W: Dan Larson (3-4) L: Wayne Twitchell (2-1) | Fourth | 20 out |
| Saturday, August 21 |
| » Lost to Phillies (79-41), 7-4 | Veteran's Stadium (1-4) | 60-66 | |
| » W: Jim Kaat (11-8) L: J.R. Richard (14-13) S: Ron Reed (12) | Fourth | 20 out |
| Sunday, August 22 |
| » Lost to Phillies (80-41), 5-1 | Veteran's Stadium (1-5) | 60-67 | Lost 2 |
| » W: Tom Underwood (9-3) L: Larry Dierker (12-12) | Fourth | 21 out |
| Tuesday, August 24 |
| » Defeated Cubs (56-70), 4-3 | Wrigley Field (1-3) | 61-67 | |
| » W: Joaquin Andujar (7-9) L: Steve Renko (5-7) S: Bo McLaughlin (1) | Fourth | 19½ out |
| Wednesday, August 25 |
| » Lost to Cubs (57-70), 5-1 | Wrigley Field (1-4) | 61-68 | |
| » W: Ray Burris (11-12) L: Dan Larson (3-5) | Fourth | 20 out |
| Thursday, August 26 |
| » Defeated Cubs (57-71), 5-3 | Wrigley Field (2-4) | 62-68 | |
| » W: J.R. Richard (15-13) L: Rick Reuschel (11-9) S: Ken Forsch (17) | Fourth | 19 out |
| Friday, August 27 |
| » Defeated Cardinals (55-67), 2-1 | Astrodome (35-30) | 63-68 | Won 2 |
| » W: Bo McLaughlin (2-2) L: Eric Rasmussen (5-10) | Fourth | 19 out |
| Saturday, August 28 |
| » Defeated Cardinals (55-68), 4-3 | Astrodome (36-30) | 64-68 | Won 3 |
| » W: Larry Dierker (13-12) L: Bob Forsch (5-10) | Third | 19 out |
| Sunday, August 29 |
| » Defeated Cardinals (55-69), 6-0 | Astrodome (37-30) | 65-68 | Won 4 |
| » W: Joe Sambito (2-1) L: Lynn McGlothen (11-12) | Third | 19 out |
| Monday, August 30 |
| » Defeated Phillies (83-46), 3-1 | Astrodome (38-30) | 66-68 | Won 5 |
| » W: Dan Larson (4-5) L: Larry Christenson (10-8) | Third | 18 out |
| Tuesday, August 31 |
| » Defeated Phillies (83-47), 3-2 | Astrodome (39-30) | 67-68 | Won 6 |
| » W: J.R. Richard (16-13) L: Tug McGraw (6-6) | Third | 18 out |
| Wednesday, September 1 |
| » Defeated Phillies (83-48), 1-0 | Astrodome (40-30) | 68-68 | Won 7 |
| » W: Bo McLaughlin (3-2) L: Jim Kaat (11-10) | Third | 17 out |
| Friday, September 3 |
| » Lost to Dodgers (77-56), 4-3 | Astrodome (40-31) | 68-69 | |
| » W: Burt Hooton (9-12) L: Larry Dierker (13-13) S: Charlie Hough (14) | Third | 18 out |
| Saturday, September 4 |
| » Defeated Dodgers (77-57), 5-2 | Astrodome (41-31) | 69-69 | |
| » W: Joaquin Andujar (8-9) L: Tommy John (8-9) | Third | 18 out |
| Sunday, September 5 |
| » Lost to Dodgers (78-57), 4-0 | Astrodome (41-32) | 69-70 | |
| » W: Doug Rau (14-10) L: Dan Larson (4-6) | Third | 19 out |
| Monday, September 6 |
| » Lost to Reds (88-50), 9-8 | Riverfront Stadium (2-6) | 69-71 | Lost 2 |
| » W: Manny Sarmiento (5-1) L: J.R. Richard (16-14) | Third | 20 out |
| Tuesday, September 7 |
| » Defeated Reds (88-51), 10-5 | Riverfront Stadium (3-6) | 70-71 | |
| » W: Joe Sambito (3-1) L: Pedro Borbon (4-3) S: Ken Forsch (18) | Third | 19 out |
| Wednesday, September 8 |
| » Lost to Reds (89-51), 3-0 | Astrodome (41-33) | 70-72 | |
| » W: Gary Nolan (12-8) L: Bo McLaughlin (3-3) S: Rawly Eastwick (20) | Third | 20 out |
| Thursday, September 9 |
| » Lost to Reds (90-51), 4-3 | Astrodome (41-34) | 70-73 | Lost 2 |
| » W: Rawly Eastwick (11-5) L: Ken Forsch (4-3) S: Will McEnaney (7) | Third | 21 out |
| Friday, September 10 |
| » Major-league debuts: Bob Knepper (Giants) |
| Saturday, September 11 |
| » Lost to Padres (67-77), 4-1 | San Diego/Jack Murphy Stadium (2-5) | 70-74 | Lost 3 |
| » W: Randy Jones (21-12) L: Larry Dierker (13-14) | Third | 22 out |
| » Defeated Padres (67-78), 2-1 | San Diego/Jack Murphy Stadium (3-5) | 71-74 | |
| » W: J.R. Richard (17-14) L: Rick Sawyer (4-2) S: Gene Pentz (4) | Third | 22 out |
| Monday, September 13 |
| Future Astro Wade Miller is born in Reading, PA. |
| Tuesday, September 14 |
| » Defeated Braves (62-83), 4-3 | Atlanta-Fulton County Stadium (5-1) | 72-74 | Won 2 |
| » W: Mark Lemongello (1-0) L: Dick Ruthven (13-15) S: Ken Forsch (19) | Third | 21½ out |
| » Lost to Braves (63-83), 4-3 | Atlanta-Fulton County Stadium (5-2) | 72-75 | |
| » W: Al Autry (1-0) L: Bo McLaughlin (3-4) S: Adrian Devine (7) | Third | 21½ out |
| » Major-league debuts: Brian Asselstine and Al Autry (Braves) |
| Wednesday, September 15 |
| » Defeated Braves (63-84), 4-3 | Atlanta-Fulton County Stadium (6-2) | 73-75 | |
| » W: Dan Larson (5-6) L: Rick Camp (0-1) | Third | 21½ out |
| » Major-league debuts: Rick Camp (Braves) |
| Thursday, September 16 |
| » Lost to Braves (64-84), 5-3 | Atlanta-Fulton County Stadium (6-3) | 73-76 | |
| » W: Phil Niekro (15-11) L: Joaquin Andujar (8-10) S: Adrian Devine (8) | Third | 22½ out |
| Saturday, September 18 |
| » Lost to Padres (68-81), 4-1 | Astrodome (41-35) | 73-77 | Lost 2 |
| » W: Dave Freisleben (10-13) L: J.R. Richard (17-15) | Third | 22 out |
| Sunday, September 19 |
| » Defeated Padres (68-82), 3-2 | Astrodome (42-35) | 74-77 | |
| » W: Mark Lemongello (2-0) L: Randy Jones (21-14) | Third | 21½ out |
| » Defeated Padres (68-83), 3-2 | Astrodome (43-35) | 75-77 | Won 2 |
| » W: Bo McLaughlin (4-4) L: Butch Metzger (11-3) | Third | 21½ out |
| Tuesday, September 21 |
| » Lost to Braves (67-86), 6-2 | Astrodome (43-36) | 75-78 | |
| » W: Phil Niekro (16-11) L: Dan Larson (5-7) | Third | 22½ out |
| Wednesday, September 22 |
| » Defeated Braves (67-87), 5-2 | Astrodome (44-36) | 76-78 | |
| » W: Joaquin Andujar (9-10) L: Frank LaCorte (3-10) | Third | 22½ out |
| Friday, September 24 |
| » Defeated Giants (70-86), 14-5 | Candlestick Park (3-4) | 77-78 | Won 2 |
| » W: J.R. Richard (18-15) L: Frank Riccelli (1-1) S: Joe Sambito (1) | Third | 21½ out |
| Saturday, September 25 |
| » Lost to Giants (71-86), 10-0 | Candlestick Park (3-5) | 77-79 | |
| » W: Jim Barr (15-11) L: Bo McLaughlin (4-5) | Third | 22½ out |
| Sunday, September 26 |
| » Lost to Giants (72-86), 5-1 | Candlestick Park (3-6) | 77-80 | Lost 2 |
| » W: Gary Lavelle (10-6) L: Mark Lemongello (2-1) S: Randy Moffitt (14) | Third | 22½ out |
| Monday, September 27 |
| » Lost to Dodgers (90-67), 2-0 | Dodger Stadium (1-6) | 77-81 | Lost 3 |
| » W: Don Sutton (21-9) L: Dan Larson (5-8) | Third | 22½ out |
| Tuesday, September 28 |
| » Defeated Dodgers (90-68), 1-0 | Dodger Stadium (2-6) | 78-81 | |
| » W: J.R. Richard (19-15) L: Burt Hooton (11-15) | Third | 22½ out |
| Wednesday, September 29 |
| » Lost to Dodgers (91-68), 1-0 | Dodger Stadium (2-7) | 78-82 | |
| » W: Stan Wall (2-2) L: Joe Sambito (3-2) S: Charlie Hough (18) | Third | 22½ out |
| » Major-league debuts: Rick Sutcliffe (Dodgers) |
| Friday, October 1 |
| » Defeated Giants (74-87), 5-4 | Astrodome (45-36) | 79-82 | |
| » W: Mark Lemongello (3-1) L: Jim Barr (15-12) S: Gene Pentz (5) | Third | 22½ out |
| Saturday, October 2 |
| » Defeated Giants (74-88), 10-1 | Astrodome (46-36) | 80-82 | Won 2 |
| » W: J.R. Richard (20-15) L: Rob Dressler (3-10) | Third | 21½ out |
| Wednesday, December 22 |
| Future Astro Jason Lane is born in Santa Rosa, CA. |
| Thursday, December 23 |
| Future Astro Brad Lidge is born in Sacramento, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |