| Monday, April 7 |
| » Major-league debuts: Jerry Remy (Angels) |
| Tuesday, April 8 |
| » Major-league debuts: Jim Umbarger (Rangers) Lyman Bostock (Twins) |
| Thursday, April 10 |
| » Lost to Orioles (1-0), 10-0 | Tiger Stadium (0-1) | 0-1 | |
| » W: Jim Palmer (1-0) L: Joe Coleman (0-1) | Third | 1 out |
| Friday, April 11 |
| » Defeated Yankees (0-2), 5-3 | Shea Stadium (1-0) | 1-1 | |
| » W: Mickey Lolich (1-0) L: Catfish Hunter (0-1) S: John Hiller (1) | Second | ½ out |
| Saturday, April 12 |
| » Defeated Yankees (0-3), 7-2 | Shea Stadium (2-0) | 2-1 | Won 2 |
| » W: Vern Ruhle (1-0) L: Pat Dobson (0-1) | Second | ½ out |
| Sunday, April 13 |
| » Lost to Yankees (1-3), 6-0 | Shea Stadium (2-1) | 2-2 | |
| » W: Doc Medich (1-1) L: Tom Walker (0-1) | First | -- |
| » Defeated Yankees (1-4), 5-2 | Shea Stadium (3-1) | 3-2 | |
| » W: Lerrin LaGrow (1-0) L: Rudy May (0-1) | First | -- |
| Monday, April 14 |
| » Major-league debuts: Dave Heaverlo (Giants) |
| Thursday, April 17 |
| » Major-league debuts: Bombo Rivera (Expos) |
| Friday, April 18 |
| » Lost to Yankees (2-6), 11-3 | Tiger Stadium (0-2) | 3-3 | |
| » W: Doc Medich (2-1) L: Joe Coleman (0-2) | Third | 1 out |
| Former Tiger Jack Burns dies in Brighton, MA at the age of 68. |
| Saturday, April 19 |
| » Defeated Yankees (2-7), 8-3 | Tiger Stadium (1-2) | 4-3 | |
| » W: Mickey Lolich (2-0) L: Catfish Hunter (0-3) | Third | 1 out |
| Sunday, April 20 |
| » Lost to Yankees (3-7), 7-1 | Tiger Stadium (1-3) | 4-4 | |
| » W: Rudy May (1-1) L: Vern Ruhle (1-1) | Third | 1½ out |
| Tuesday, April 22 |
| » Defeated Indians (3-5), 6-2 | Tiger Stadium (2-3) | 5-4 | |
| » W: Lerrin LaGrow (2-0) L: Gaylord Perry (2-2) | First | -- |
| Wednesday, April 23 |
| » Lost to Indians (4-5), 4-3 | Tiger Stadium (2-4) | 5-5 | |
| » W: Jim Perry (1-2) L: Joe Coleman (0-3) S: Tom Buskey (2) | Second | 1 out |
| Friday, April 25 |
| » Defeated Red Sox (7-6), 1-0 | Tiger Stadium (3-4) | 6-5 | |
| » W: Mickey Lolich (3-0) L: Luis Tiant (2-2) | Second | ½ out |
| Saturday, April 26 |
| » Defeated Red Sox (7-7), 3-2 | Tiger Stadium (4-4) | 7-5 | Won 2 |
| » W: John Hiller (1-0) L: Bill Lee (1-3) | First | -- |
| Sunday, April 27 |
| » Defeated Red Sox (7-8), 5-4 | Tiger Stadium (5-4) | 8-5 | Won 3 |
| » W: Lerrin LaGrow (3-0) L: Rick Wise (1-2) S: John Hiller (2) | First | -- |
| Monday, April 28 |
| » Defeated Orioles (7-7), 5-3 | Memorial Stadium (1-0) | 9-5 | Won 4 |
| » W: Joe Coleman (1-3) L: Mike Cuellar (1-1) S: John Hiller (3) | First | -- |
| Tuesday, April 29 |
| » Defeated Orioles (7-8), 4-2 | Memorial Stadium (2-0) | 10-5 | Won 5 |
| » W: Tom Walker (1-1) L: Ross Grimsley (0-2) | First | -- |
| Wednesday, April 30 |
| » Lost to Brewers (9-7), 6-2 | County Stadium (0-1) | 10-6 | |
| » W: Jim Slaton (2-4) L: Dave Lemanczyk (0-1) S: Eduardo Rodriguez (1) | First | -- |
| Thursday, May 1 |
| » Lost to Brewers (10-7), 17-3 | County Stadium (0-2) | 10-7 | Lost 2 |
| » W: Pete Broberg (4-2) L: Ray Bare (0-1) S: Jim Colborn (1) | First | -- |
| Saturday, May 3 |
| » Lost to Red Sox (9-9), 12-2 | Fenway Park (0-1) | 10-8 | Lost 3 |
| » W: Rick Wise (2-2) L: Lerrin LaGrow (3-1) | Second | 1½ out |
| Sunday, May 4 |
| » Major-league debuts: Glenn Adams (Giants) |
| Tuesday, May 6 |
| » Defeated Brewers (13-8), 4-2 | Tiger Stadium (6-4) | 11-8 | |
| » W: Joe Coleman (2-3) L: Pete Broberg (4-3) | Second | 1 out |
| Wednesday, May 7 |
| » Lost to Brewers (14-8), 7-5 | Tiger Stadium (6-5) | 11-9 | |
| » W: Eduardo Rodriguez (2-0) L: Mickey Lolich (3-1) | Third | 2 out |
| Thursday, May 8 |
| » Defeated Brewers (14-9), 6-4 | Tiger Stadium (7-5) | 12-9 | |
| » W: Ray Bare (1-1) L: Jim Colborn (0-1) S: John Hiller (4) | Second | 1 out |
| Friday, May 9 |
| » Lost to Rangers (15-12), 3-1 | Tiger Stadium (7-6) | 12-10 | |
| » W: Jackie Brown (2-2) L: Lerrin LaGrow (3-2) | Third | 2 out |
| Saturday, May 10 |
| » Lost to Rangers (16-12), 5-2 | Tiger Stadium (7-7) | 12-11 | Lost 2 |
| » W: Bill Hands (3-2) L: Joe Coleman (2-4) | Third | 3 out |
| Sunday, May 11 |
| » Lost to Rangers (17-12), 11-7 | Tiger Stadium (7-8) | 12-12 | Lost 3 |
| » W: Fergie Jenkins (5-2) L: Mickey Lolich (3-2) S: Steve Foucault (3) | Third | 3 out |
| Future Tiger Francisco Cordero is born in Santo Domingo, D.R. |
| Monday, May 12 |
| » Defeated Royals (15-16), 5-0 | Tiger Stadium (8-8) | 13-12 | |
| » W: Vern Ruhle (2-1) L: Dennis Leonard (0-1) | Third | 2½ out |
| Tuesday, May 13 |
| » Lost to Royals (16-16), 8-7 | Tiger Stadium (8-9) | 13-13 | |
| » W: Al Fitzmorris (4-3) L: Lerrin LaGrow (3-3) | Third | 2½ out |
| Wednesday, May 14 |
| » Lost to Royals (17-16), 4-1 | Tiger Stadium (8-10) | 13-14 | Lost 2 |
| » W: Nelson Briles (4-1) L: Joe Coleman (2-5) | Fourth | 3 out |
| Friday, May 16 |
| » Lost to Rangers (19-14), 10-3 | Arlington Stadium (0-1) | 13-15 | Lost 3 |
| » W: Bill Hands (4-2) L: Mickey Lolich (3-3) | Fourth | 5 out |
| Saturday, May 17 |
| » Defeated Rangers (19-15), 6-4 | Arlington Stadium (1-1) | 14-15 | |
| » W: Vern Ruhle (3-1) L: Jackie Brown (2-4) S: John Hiller (5) | Second | 4 out |
| Sunday, May 18 |
| » Lost to Rangers (20-15), 7-6 | Arlington Stadium (1-2) | 14-16 | |
| » W: Stan Thomas (1-0) L: Dave Lemanczyk (0-2) | Third | 4 out |
| Monday, May 19 |
| » Defeated Twins (16-16), 6-3 | Metropolitan Stadium (1-0) | 15-16 | |
| » W: Joe Coleman (3-5) L: Mike Pazik (0-2) S: John Hiller (6) | Third | 3½ out |
| Tuesday, May 20 |
| » Defeated Twins (16-17), 5-3 | Metropolitan Stadium (2-0) | 16-16 | Won 2 |
| » W: Mickey Lolich (4-3) L: Dave Goltz (2-4) | Third | 3½ out |
| Wednesday, May 21 |
| » Lost to Twins (17-17), 6-5 | Metropolitan Stadium (2-1) | 16-17 | |
| » W: Ray Corbin (2-2) L: John Hiller (1-1) | Third | 3½ out |
| Friday, May 23 |
| » Lost to White Sox (17-21), 6-1 | Comiskey Park I (0-1) | 16-18 | Lost 2 |
| » W: Terry Forster (3-3) L: Lerrin LaGrow (3-4) | Third | 3 out |
| Saturday, May 24 |
| » Lost to White Sox (18-21), 10-8 | Comiskey Park I (0-2) | 16-19 | Lost 3 |
| » W: Stan Bahnsen (2-4) L: Joe Coleman (3-6) S: Bill Gogolewski (1) | Third | 3½ out |
| Sunday, May 25 |
| » Defeated White Sox (18-22), 4-1 | Comiskey Park I (1-2) | 17-19 | |
| » W: Mickey Lolich (5-3) L: Claude Osteen (1-5) | Third | 2½ out |
| Monday, May 26 |
| » Defeated Twins (20-18), 6-2 | Tiger Stadium (9-10) | 18-19 | Won 2 |
| » W: Vern Ruhle (4-1) L: Bill Campbell (0-3) | Third | 2½ out |
| Future Tiger Randall Simon is born in Willemstad, Curacao. |
| Tuesday, May 27 |
| » Lost to Twins (21-18), 6-5 | Tiger Stadium (9-11) | 18-20 | |
| » W: Vic Albury (3-2) L: John Hiller (1-2) | Third | 3 out |
| Wednesday, May 28 |
| » Lost to Twins (22-18), 5-2 | Tiger Stadium (9-12) | 18-21 | Lost 2 |
| » W: Jim Hughes (6-1) L: Joe Coleman (3-7) | Third | 4 out |
| Friday, May 30 |
| Former Tiger Bert Cole dies in San Mateo, CA at the age of 79. |
| Saturday, May 31 |
| » Defeated White Sox (20-24), 2-0 | Tiger Stadium (10-12) | 19-21 | |
| » W: Vern Ruhle (5-1) L: Jim Kaat (8-2) | Third | 3½ out |
| Sunday, June 1 |
| » Defeated White Sox (20-25), 5-1 | Tiger Stadium (11-12) | 20-21 | Won 2 |
| » W: Mickey Lolich (6-3) L: Wilbur Wood (2-9) | Fourth | 4 out |
| » Lost to White Sox (21-25), 3-2 | Tiger Stadium (11-13) | 20-22 | |
| » W: Rich Gossage (3-2) L: Tom Walker (1-2) | Fourth | 4 out |
| Tuesday, June 3 |
| » Defeated Angels (23-27), 8-5 | Anaheim Stadium (1-0) | 21-22 | |
| » W: John Hiller (2-2) L: Frank Tanana (2-4) | Fourth | 3½ out |
| Wednesday, June 4 |
| » Lost to Angels (24-27), 2-1 | Anaheim Stadium (1-1) | 21-23 | |
| » W: Ed Figueroa (4-1) L: Ray Bare (1-2) | Fourth | 4½ out |
| Thursday, June 5 |
| » Lost to Angels (25-27), 8-3 | Anaheim Stadium (1-2) | 21-24 | Lost 2 |
| » W: Bill Singer (5-7) L: Vern Ruhle (5-2) | Fourth | 5 out |
| Friday, June 6 |
| » Defeated Athletics (30-21), 11-2 | Oakland-Alameda County Stadium (1-0) | 22-24 | |
| » W: Mickey Lolich (7-3) L: Dick Bosman (2-3) S: John Hiller (7) | Fourth | 5 out |
| Saturday, June 7 |
| » Defeated Athletics (30-22), 3-0 | Oakland-Alameda County Stadium (2-0) | 23-24 | Won 2 |
| » W: Lerrin LaGrow (4-4) L: Vida Blue (9-4) | Third | 5 out |
| Sunday, June 8 |
| » Lost to Athletics (31-22), 4-0 | Oakland-Alameda County Stadium (2-1) | 23-25 | |
| » W: Ken Holtzman (5-6) L: Joe Coleman (3-8) | Fourth | 5 out |
| Former Tiger Ownie Carroll dies in Orange, NJ at the age of 73. |
| Monday, June 9 |
| » Lost to Royals (31-25), 5-2 | Royals Stadium (0-1) | 23-26 | Lost 2 |
| » W: Lindy McDaniel (3-0) L: Tom Walker (1-3) | Fourth | 5 out |
| Tuesday, June 10 |
| » Lost to Royals (32-25), 4-3 | Royals Stadium (0-2) | 23-27 | Lost 3 |
| » W: Marty Pattin (4-2) L: Vern Ruhle (5-3) S: Lindy McDaniel (1) | Fourth | 5 out |
| Wednesday, June 11 |
| » Lost to Angels (29-29), 14-7 | Tiger Stadium (11-14) | 23-28 | Lost 4 |
| » W: Frank Tanana (4-4) L: Mickey Lolich (7-4) | Fourth | 6 out |
| » Defeated Angels (29-30), 5-3 | Tiger Stadium (12-14) | 24-28 | |
| » W: Ray Bare (2-2) L: Andy Hassler (3-6) S: John Hiller (8) | Fourth | 6 out |
| Thursday, June 12 |
| » Lost to Angels (30-30), 7-1 | Tiger Stadium (12-15) | 24-29 | |
| » W: Ed Figueroa (5-2) L: Lerrin LaGrow (4-5) | Fourth | 5½ out |
| Friday, June 13 |
| » Lost to Athletics (35-23), 7-5 | Tiger Stadium (12-16) | 24-30 | Lost 2 |
| » W: Paul Lindblad (5-0) L: Joe Coleman (3-9) S: Rollie Fingers (7) | Fourth | 6 out |
| Saturday, June 14 |
| » Defeated Athletics (35-24), 3-2 | Tiger Stadium (13-16) | 25-30 | |
| » W: Tom Walker (2-3) L: Sonny Siebert (5-3) S: John Hiller (9) | Fourth | 6 out |
| Sunday, June 15 |
| Future Tiger Chris Wakeland is born in Huntington Beach, CA. |
| Monday, June 16 |
| » Lost to Red Sox (33-24), 6-2 | Tiger Stadium (13-17) | 25-31 | |
| » W: Reggie Cleveland (4-3) L: Tom Walker (2-4) | Fifth | 7½ out |
| Tuesday, June 17 |
| » Lost to Red Sox (34-24), 7-6 | Tiger Stadium (13-18) | 25-32 | Lost 2 |
| » W: Rick Wise (7-5) L: Lerrin LaGrow (4-6) S: Dick Drago (6) | Fifth | 8½ out |
| » Major-league debuts: Ike Brookens (Tigers) |
| Wednesday, June 18 |
| » Lost to Red Sox (35-24), 15-1 | Tiger Stadium (13-19) | 25-33 | Lost 3 |
| » W: Luis Tiant (9-6) L: Joe Coleman (3-10) | Fifth | 9½ out |
| Thursday, June 19 |
| » Lost to Yankees (35-28), 9-2 | Tiger Stadium (13-20) | 25-34 | Lost 4 |
| » W: Catfish Hunter (10-6) L: Ray Bare (2-3) | Fifth | 10 out |
| Future Tiger Willis Roberts is born in San Cristobal, D.R. |
| Friday, June 20 |
| » Defeated Yankees (35-29), 10-9 | Tiger Stadium (14-20) | 26-34 | |
| » W: Vern Ruhle (6-3) L: Rudy May (7-3) | Fifth | 10 out |
| Saturday, June 21 |
| » Lost to Yankees (36-29), 4-1 | Tiger Stadium (14-21) | 26-35 | |
| » W: Pat Dobson (8-5) L: Mickey Lolich (7-5) | Fifth | 10 out |
| Sunday, June 22 |
| » Lost to Yankees (37-29), 5-3 | Tiger Stadium (14-22) | 26-36 | Lost 2 |
| » W: Larry Gura (2-1) L: Tom Walker (2-5) S: Dick Tidrow (4) | Fifth | 10½ out |
| Monday, June 23 |
| » Lost to Brewers (34-32), 8-4 | County Stadium (0-3) | 26-37 | Lost 3 |
| » W: Tom Hausman (2-1) L: Joe Coleman (3-11) | Fifth | 10½ out |
| Tuesday, June 24 |
| » Lost to Brewers (35-32), 5-0 | County Stadium (0-4) | 26-38 | Lost 4 |
| » W: Jim Slaton (6-8) L: Ray Bare (2-4) | Sixth | 11½ out |
| » Lost to Brewers (36-32), 4-2 | County Stadium (0-5) | 26-39 | Lost 5 |
| » W: Bill Travers (3-0) L: Lerrin LaGrow (4-7) | Sixth | 11½ out |
| Wednesday, June 25 |
| » Lost to Brewers (37-32), 7-6 | County Stadium (0-6) | 26-40 | Lost 6 |
| » W: Pete Broberg (8-7) L: Vern Ruhle (6-4) S: Ed Sprague (1) | Sixth | 12½ out |
| Thursday, June 26 |
| » Defeated Orioles (30-38), 6-5 | Memorial Stadium (3-0) | 27-40 | |
| » W: Mickey Lolich (8-5) L: Doyle Alexander (1-5) | Sixth | 11½ out |
| Friday, June 27 |
| » Lost to Orioles (31-38), 3-2 | Memorial Stadium (3-1) | 27-41 | |
| » W: Ross Grimsley (4-9) L: John Hiller (2-3) | Sixth | 12 out |
| Saturday, June 28 |
| » Lost to Orioles (32-38), 7-4 | Memorial Stadium (3-2) | 27-42 | Lost 2 |
| » W: Mike Torrez (8-5) L: Joe Coleman (3-12) S: Grant Jackson (2) | Sixth | 12½ out |
| » Major-league debuts: Fernando Arroyo (Tigers) |
| Sunday, June 29 |
| » Lost to Orioles (33-38), 2-1 | Memorial Stadium (3-3) | 27-43 | Lost 3 |
| » W: Mike Cuellar (6-5) L: Ray Bare (2-5) | Sixth | 13 out |
| Monday, June 30 |
| » Lost to Indians (31-41), 4-1 | Cleveland Stadium (0-1) | 27-44 | Lost 4 |
| » W: Roric Harrison (5-6) L: Vern Ruhle (6-5) | Sixth | 14 out |
| » Lost to Indians (32-41), 3-2 | Cleveland Stadium (0-2) | 27-45 | Lost 5 |
| » W: Eric Raich (4-2) L: Lerrin LaGrow (4-8) | Sixth | 14 out |
| Tuesday, July 1 |
| » Defeated Indians (32-42), 6-2 | Cleveland Stadium (1-2) | 28-45 | |
| » W: Mickey Lolich (9-5) L: Jim Bibby (3-8) | Fifth | 13 out |
| Wednesday, July 2 |
| » Lost to Orioles (36-39), 13-5 | Tiger Stadium (14-23) | 28-46 | |
| » W: Mike Torrez (9-5) L: Tom Walker (2-6) | Sixth | 13½ out |
| Thursday, July 3 |
| » Defeated Orioles (36-40), 9-5 | Tiger Stadium (15-23) | 29-46 | |
| » W: Joe Coleman (4-12) L: Wayne Garland (0-3) | Sixth | 12½ out |
| Friday, July 4 |
| » Defeated Brewers (43-36), 8-2 | Tiger Stadium (16-23) | 30-46 | Won 2 |
| » W: Ray Bare (3-5) L: Bill Travers (4-1) | Sixth | 11½ out |
| Saturday, July 5 |
| » Defeated Brewers (43-37), 3-2 | Tiger Stadium (17-23) | 31-46 | Won 3 |
| » W: Vern Ruhle (7-5) L: Jim Colborn (3-7) | Sixth | 10½ out |
| Sunday, July 6 |
| » Defeated Brewers (43-38), 7-5 | Tiger Stadium (18-23) | 32-46 | Won 4 |
| » W: Mickey Lolich (10-5) L: Tom Hausman (2-2) S: John Hiller (10) | Sixth | 9½ out |
| » Defeated Brewers (43-39), 11-2 | Tiger Stadium (19-23) | 33-46 | Won 5 |
| » W: Lerrin LaGrow (5-8) L: Pete Broberg (9-8) | Sixth | 9½ out |
| Monday, July 7 |
| » Defeated White Sox (38-42), 2-1 | Tiger Stadium (20-23) | 34-46 | Won 6 |
| » W: Tom Walker (3-6) L: Jim Kaat (13-5) | Sixth | 9½ out |
| Tuesday, July 8 |
| » Defeated White Sox (38-43), 3-0 | Tiger Stadium (21-23) | 35-46 | Won 7 |
| » W: Joe Coleman (5-12) L: Wilbur Wood (6-13) S: John Hiller (11) | Sixth | 9½ out |
| Wednesday, July 9 |
| » Defeated White Sox (38-44), 6-2 | Tiger Stadium (22-23) | 36-46 | Won 8 |
| » W: Ray Bare (4-5) L: Jesse Jefferson (1-4) | Sixth | 9½ out |
| Thursday, July 10 |
| » Defeated Royals (46-39), 3-2 | Royals Stadium (1-2) | 37-46 | Won 9 |
| » W: Vern Ruhle (8-5) L: Steve Busby (11-7) S: Bob Reynolds (1) | Fifth | 9½ out |
| Friday, July 11 |
| » Lost to Royals (47-39), 5-2 | Royals Stadium (1-3) | 37-47 | |
| » W: Marty Pattin (7-5) L: Mickey Lolich (10-6) | Fifth | 10½ out |
| Saturday, July 12 |
| » Defeated Royals (47-40), 2-0 | Royals Stadium (2-3) | 38-47 | |
| » W: Lerrin LaGrow (6-8) L: Al Fitzmorris (9-6) | Sixth | 10½ out |
| Sunday, July 13 |
| » Defeated Royals (47-41), 8-4 | Royals Stadium (3-3) | 39-47 | Won 2 |
| » W: Joe Coleman (6-12) L: Dennis Leonard (5-5) S: John Hiller (12) | Sixth | 10½ out |
| Thursday, July 17 |
| » Lost to White Sox (41-45), 4-0 | Comiskey Park I (1-3) | 39-48 | |
| » W: Wilbur Wood (8-13) L: Mickey Lolich (10-7) | Sixth | 11 out |
| » Defeated White Sox (41-46), 9-1 | Comiskey Park I (2-3) | 40-48 | |
| » W: Lerrin LaGrow (7-8) L: Claude Osteen (5-7) | Sixth | 11 out |
| Friday, July 18 |
| » Lost to White Sox (42-46), 4-0 | Comiskey Park I (2-4) | 40-49 | |
| » W: Jim Kaat (14-6) L: Vern Ruhle (8-6) | Sixth | 12 out |
| Saturday, July 19 |
| » Defeated Royals (47-44), 10-8 | Tiger Stadium (23-23) | 41-49 | |
| » W: Joe Coleman (7-12) L: Marty Pattin (7-6) S: John Hiller (13) | Fifth | 12 out |
| Sunday, July 20 |
| » Defeated Royals (47-45), 7-3 | Tiger Stadium (24-23) | 42-49 | Won 2 |
| » W: Ray Bare (5-5) L: Nelson Briles (4-5) | Fifth | 11½ out |
| Monday, July 21 |
| » Lost to Royals (48-45), 3-2 | Tiger Stadium (24-24) | 42-50 | |
| » W: Dennis Leonard (6-5) L: Mickey Lolich (10-8) S: Steve Mingori (1) | Fifth | 11½ out |
| Tuesday, July 22 |
| » Lost to Athletics (59-35), 11-0 | Tiger Stadium (24-25) | 42-51 | Lost 2 |
| » W: Glenn Abbott (5-2) L: Tom Walker (3-7) | Sixth | 13 out |
| » Lost to Athletics (60-35), 16-4 | Tiger Stadium (24-26) | 42-52 | Lost 3 |
| » W: Stan Bahnsen (6-8) L: Lerrin LaGrow (7-9) | Sixth | 13 out |
| Wednesday, July 23 |
| » Lost to Athletics (61-35), 3-0 | Tiger Stadium (24-27) | 42-53 | Lost 4 |
| » W: Vida Blue (13-8) L: Vern Ruhle (8-7) | Sixth | 14 out |
| Thursday, July 24 |
| » Defeated Athletics (61-36), 5-2 | Tiger Stadium (25-27) | 43-53 | |
| » W: Joe Coleman (8-12) L: Jim Perry (4-9) S: John Hiller (14) | Fifth | 14 out |
| Friday, July 25 |
| » Defeated Indians (42-53), 4-3 | Tiger Stadium (26-27) | 44-53 | Won 2 |
| » W: Ray Bare (6-5) L: Don Hood (3-6) S: Bob Reynolds (2) | Fifth | 13 out |
| Saturday, July 26 |
| » Lost to Indians (43-53), 6-0 | Tiger Stadium (26-28) | 44-54 | |
| » W: Dennis Eckersley (7-3) L: Mickey Lolich (10-9) | Fifth | 14 out |
| Sunday, July 27 |
| » Defeated Indians (43-54), 8-7 | Tiger Stadium (27-28) | 45-54 | |
| » W: Fernando Arroyo (1-0) L: Dave LaRoche (4-3) S: Bob Reynolds (3) | Fifth | 15 out |
| » Lost to Indians (44-54), 7-2 | Tiger Stadium (27-29) | 45-55 | |
| » W: Fritz Peterson (5-7) L: Lerrin LaGrow (7-10) | Fifth | 15 out |
| Monday, July 28 |
| » Defeated Yankees (50-51), 3-0 | Shea Stadium (4-1) | 46-55 | |
| » W: Vern Ruhle (9-7) L: Larry Gura (3-4) | Sixth | 15 out |
| Tuesday, July 29 |
| » Lost to Yankees (51-51), 4-2 | Shea Stadium (4-2) | 46-56 | |
| » W: Doc Medich (8-12) L: Joe Coleman (8-13) S: Tippy Martinez (3) | Fifth | 15 out |
| » Major-league debuts: Gene Pentz (Tigers) |
| Future Tiger Seth Greisinger is born in Kansas City, KS. |
| Wednesday, July 30 |
| » Lost to Yankees (52-51), 2-1 | Shea Stadium (4-3) | 46-57 | Lost 2 |
| » W: Rudy May (10-6) L: Mickey Lolich (10-10) | Sixth | 15 out |
| Thursday, July 31 |
| » Lost to Red Sox (62-42), 3-2 | Fenway Park (0-2) | 46-58 | Lost 3 |
| » W: Bill Lee (14-6) L: Bob Reynolds (0-2) | Sixth | 17 out |
| » Lost to Red Sox (63-42), 6-1 | Fenway Park (0-3) | 46-59 | Lost 4 |
| » W: Roger Moret (8-1) L: Dave Lemanczyk (0-3) | Sixth | 17 out |
| Friday, August 1 |
| » Lost to Red Sox (64-42), 8-7 | Fenway Park (0-4) | 46-60 | Lost 5 |
| » W: Jim Willoughby (2-0) L: Gene Pentz (0-1) | Sixth | 18 out |
| Saturday, August 2 |
| » Lost to Red Sox (65-42), 7-2 | Fenway Park (0-5) | 46-61 | Lost 6 |
| » W: Rick Wise (14-6) L: Vern Ruhle (9-8) | Sixth | 19 out |
| Sunday, August 3 |
| » Lost to Red Sox (66-42), 6-4 | Fenway Park (0-6) | 46-62 | Lost 7 |
| » W: Reggie Cleveland (9-7) L: Tom Walker (3-8) S: Jim Willoughby (6) | Sixth | 20 out |
| Monday, August 4 |
| » Lost to Indians (48-58), 6-4 | Cleveland Stadium (1-3) | 46-63 | Lost 8 |
| » W: Dennis Eckersley (9-3) L: Mickey Lolich (10-11) S: Jackie Brown (1) | Sixth | 20 out |
| Tuesday, August 5 |
| » Lost to Indians (49-58), 8-4 | Cleveland Stadium (1-4) | 46-64 | Lost 9 |
| » W: Eric Raich (6-6) L: Ray Bare (6-6) S: Rick Waits (1) | Sixth | 20 out |
| Wednesday, August 6 |
| » Lost to Orioles (58-50), 4-2 | Tiger Stadium (27-30) | 46-65 | Lost 10 |
| » W: Mike Torrez (14-6) L: Lerrin LaGrow (7-11) S: Wayne Garland (3) | Sixth | 21½ out |
| » Lost to Orioles (59-50), 8-2 | Tiger Stadium (27-31) | 46-66 | Lost 11 |
| » W: Ross Grimsley (8-11) L: Dave Lemanczyk (0-4) S: Dyar Miller (5) | Sixth | 21½ out |
| Thursday, August 7 |
| » Lost to Orioles (60-50), 7-6 | Tiger Stadium (27-32) | 46-67 | Lost 12 |
| » W: Dyar Miller (3-2) L: Bob Reynolds (0-3) | Sixth | 22½ out |
| Friday, August 8 |
| » Lost to Twins (50-65), 3-1 | Tiger Stadium (27-33) | 46-68 | Lost 13 |
| » W: Jim Hughes (10-9) L: Joe Coleman (8-14) | Sixth | 22½ out |
| Saturday, August 9 |
| » Lost to Twins (51-65), 1-0 | Tiger Stadium (27-34) | 46-69 | Lost 14 |
| » W: Dave Goltz (9-10) L: Mickey Lolich (10-12) | Sixth | 23½ out |
| Sunday, August 10 |
| » Lost to Twins (52-65), 4-0 | Tiger Stadium (27-35) | 46-70 | Lost 15 |
| » W: Bert Blyleven (11-6) L: Ray Bare (6-7) | Sixth | 24½ out |
| Monday, August 11 |
| » Lost to Rangers (56-61), 7-0 | Tiger Stadium (27-36) | 46-71 | Lost 16 |
| » W: Gaylord Perry (12-15) L: Lerrin LaGrow (7-12) | Sixth | 24½ out |
| Tuesday, August 12 |
| » Lost to Rangers (57-61), 4-3 | Tiger Stadium (27-37) | 46-72 | Lost 17 |
| » W: Stan Perzanowski (1-1) L: Vern Ruhle (9-9) S: Steve Foucault (6) | Sixth | 25½ out |
| Wednesday, August 13 |
| » Lost to Rangers (58-61), 6-5 | Tiger Stadium (27-38) | 46-73 | Lost 18 |
| » W: Steve Foucault (4-2) L: Gene Pentz (0-2) | Sixth | 25½ out |
| Friday, August 15 |
| » Lost to Angels (55-67), 8-0 | Anaheim Stadium (1-3) | 46-74 | Lost 19 |
| » W: Frank Tanana (11-6) L: Mickey Lolich (10-13) | Sixth | 26 out |
| Saturday, August 16 |
| » Defeated Angels (55-68), 8-0 | Anaheim Stadium (2-3) | 47-74 | |
| » W: Ray Bare (7-7) L: Chuck Hockenbery (0-3) | Sixth | 26 out |
| Sunday, August 17 |
| » Defeated Angels (55-69), 7-0 | Anaheim Stadium (3-3) | 48-74 | Won 2 |
| » W: Vern Ruhle (10-9) L: Ed Figueroa (11-9) | Sixth | 25½ out |
| Monday, August 18 |
| » Defeated Athletics (74-49), 5-3 | Oakland-Alameda County Stadium (3-1) | 49-74 | Won 3 |
| » W: Joe Coleman (9-14) L: Vida Blue (16-10) | Sixth | 25 out |
| Tuesday, August 19 |
| » Defeated Athletics (74-50), 3-1 | Oakland-Alameda County Stadium (4-1) | 50-74 | Won 4 |
| » W: Mickey Lolich (11-13) L: Dick Bosman (8-5) | Sixth | 25 out |
| Wednesday, August 20 |
| » Lost to Athletics (75-50), 2-1 | Oakland-Alameda County Stadium (4-2) | 50-75 | |
| » W: Sonny Siebert (6-5) L: Ray Bare (7-8) S: Jim Todd (9) | Sixth | 25 out |
| Friday, August 22 |
| » Lost to Twins (59-68), 8-4 | Metropolitan Stadium (2-2) | 50-76 | Lost 2 |
| » W: Dave Goltz (12-10) L: Vern Ruhle (10-10) S: Bill Campbell (4) | Sixth | 26 out |
| » Major-league debuts: Dave McKay (Twins) |
| Saturday, August 23 |
| » Defeated Twins (59-69), 6-5 | Metropolitan Stadium (3-2) | 51-76 | |
| » W: Dave Lemanczyk (1-4) L: Tom Burgmeier (5-7) | Sixth | 25 out |
| Sunday, August 24 |
| » Lost to Twins (60-69), 3-1 | Metropolitan Stadium (3-3) | 51-77 | |
| » W: Jim Hughes (12-11) L: Mickey Lolich (11-14) | Sixth | 26 out |
| Monday, August 25 |
| » Lost to Rangers (64-67), 1-0 | Arlington Stadium (1-3) | 51-78 | Lost 2 |
| » W: Jim Umbarger (6-5) L: Ray Bare (7-9) | Sixth | 26½ out |
| Tuesday, August 26 |
| » Lost to Rangers (65-67), 3-2 | Arlington Stadium (1-4) | 51-79 | Lost 3 |
| » W: Gaylord Perry (14-15) L: Gene Pentz (0-3) | Sixth | 26½ out |
| Wednesday, August 27 |
| » Lost to Rangers (66-67), 8-2 | Arlington Stadium (1-5) | 51-80 | Lost 4 |
| » W: Fergie Jenkins (16-13) L: Lerrin LaGrow (7-13) | Sixth | 27½ out |
| Friday, August 29 |
| » Lost to Angels (62-72), 8-1 | Tiger Stadium (27-39) | 51-81 | Lost 5 |
| » W: Frank Tanana (13-6) L: Mickey Lolich (11-15) | Sixth | 28½ out |
| Saturday, August 30 |
| » Defeated Angels (62-73), 9-2 | Tiger Stadium (28-39) | 52-81 | |
| » W: Ray Bare (8-9) L: Chuck Hockenbery (0-4) | Sixth | 27½ out |
| Sunday, August 31 |
| Future Tiger Gabe Kapler is born in Hollywood, CA. |
| Monday, September 1 |
| » Defeated Brewers (59-77), 5-4 | Tiger Stadium (29-39) | 53-81 | Won 2 |
| » W: Dave Lemanczyk (2-4) L: Rick Austin (2-3) | Sixth | 26 out |
| Tuesday, September 2 |
| » Lost to Brewers (60-77), 6-5 | Tiger Stadium (29-40) | 53-82 | |
| » W: Jim Colborn (10-9) L: Joe Coleman (9-15) S: Eduardo Rodriguez (7) | Sixth | 27 out |
| Wednesday, September 3 |
| » Lost to Yankees (69-68), 8-0 | Tiger Stadium (29-41) | 53-83 | Lost 2 |
| » W: Catfish Hunter (19-13) L: Mickey Lolich (11-16) | Sixth | 28 out |
| Thursday, September 4 |
| » Lost to Yankees (70-68), 8-1 | Tiger Stadium (29-42) | 53-84 | Lost 3 |
| » W: Rudy May (12-10) L: Ray Bare (8-10) | Sixth | 29 out |
| Friday, September 5 |
| » Defeated Indians (64-70), 11-2 | Cleveland Stadium (2-4) | 54-84 | |
| » W: Vern Ruhle (11-10) L: Rick Waits (3-1) | Sixth | 28 out |
| » Major-league debuts: Larry Andersen (Indians) |
| Saturday, September 6 |
| » Lost to Indians (65-70), 4-2 | Cleveland Stadium (2-5) | 54-85 | |
| » W: Dennis Eckersley (11-5) L: Dave Lemanczyk (2-5) S: Dave LaRoche (14) | Sixth | 29 out |
| Sunday, September 7 |
| » Lost to Indians (66-70), 7-2 | Cleveland Stadium (2-6) | 54-86 | Lost 2 |
| » W: Jim Bibby (6-14) L: Joe Coleman (9-16) S: Tom Buskey (6) | Sixth | 30 out |
| » Lost to Indians (67-70), 9-0 | Cleveland Stadium (2-7) | 54-87 | Lost 3 |
| » W: Fritz Peterson (12-7) L: Lerrin LaGrow (7-14) | Sixth | 30 out |
| Monday, September 8 |
| » Lost to Yankees (72-71), 3-0 | Shea Stadium (4-4) | 54-88 | Lost 4 |
| » W: Rudy May (13-10) L: Mickey Lolich (11-17) | Sixth | 30 out |
| Tuesday, September 9 |
| » Lost to Yankees (73-71), 9-6 | Shea Stadium (4-5) | 54-89 | Lost 5 |
| » W: Doc Medich (13-16) L: Ray Bare (8-11) S: Tippy Martinez (7) | Sixth | 30 out |
| Wednesday, September 10 |
| » Lost to Red Sox (85-59), 7-4 | Fenway Park (0-7) | 54-90 | Lost 6 |
| » W: Roger Moret (13-3) L: Vern Ruhle (11-11) S: Dick Drago (12) | Sixth | 30 out |
| » Defeated Red Sox (85-60), 5-3 | Fenway Park (1-7) | 55-90 | |
| » W: Fernando Arroyo (2-0) L: Jim Willoughby (4-2) | Sixth | 30 out |
| Thursday, September 11 |
| » Lost to Red Sox (86-60), 3-1 | Fenway Park (1-8) | 55-91 | |
| » W: Luis Tiant (16-13) L: Dave Lemanczyk (2-6) | Sixth | 31 out |
| Friday, September 12 |
| » Lost to Orioles (82-65), 6-4 | Tiger Stadium (29-43) | 55-92 | Lost 2 |
| » W: Mike Torrez (18-8) L: Joe Coleman (9-17) S: Dyar Miller (7) | Sixth | 31½ out |
| Saturday, September 13 |
| » Lost to Orioles (83-65), 8-0 | Tiger Stadium (29-44) | 55-93 | Lost 3 |
| » W: Doyle Alexander (8-8) L: Mickey Lolich (11-18) | Sixth | 32 out |
| Sunday, September 14 |
| » Lost to Orioles (84-65), 9-3 | Tiger Stadium (29-45) | 55-94 | |
