| Sunday, January 12 |
| Future Padre Jorge Velandia is born in Caracas, Venezuela. |
| Wednesday, January 29 |
| Future Padre Miguel Ojeda is born in Sonora, Mexico. |
| Sunday, February 23 |
| Future Padre Dave Maurer is born in Minneapolis, MN. |
| Wednesday, March 12 |
| Future Padre Kevin Pickford is born in Fresno, CA. |
| Saturday, April 5 |
| Future Padre Domingo Guzman is born in San Cristobal, D.R. |
| Monday, April 7 |
| » Major-league debuts: Jerry Remy (Angels) |
| Tuesday, April 8 |
| » Major-league debuts: Jim Umbarger (Rangers) Lyman Bostock (Twins) |
| Future Padre Jeremy Fikac is born in Shiner, TX. |
| Thursday, April 10 |
| » Lost to Giants (1-0), 2-0 | San Diego/Jack Murphy Stadium (0-1) | 0-1 | |
| » W: Jim Barr (1-0) L: Rich Folkers (0-1) | Fifth | 2 out |
| » Major-league debuts: Horace Speed (Giants) |
| Friday, April 11 |
| » Defeated Reds (3-1), 5-2 | San Diego/Jack Murphy Stadium (1-1) | 1-1 | |
| » W: Dan Spillner (1-0) L: Fred Norman (0-1) | Second | 1 out |
| Saturday, April 12 |
| » Defeated Reds (3-2), 3-2 | San Diego/Jack Murphy Stadium (2-1) | 2-1 | Won 2 |
| » W: Joe McIntosh (1-0) L: Gary Nolan (0-1) S: Bill Greif (1) | First | -- |
| Sunday, April 13 |
| » Lost to Reds (4-2), 10-0 | San Diego/Jack Murphy Stadium (2-2) | 2-2 | |
| » W: Don Gullett (1-0) L: Dave Freisleben (0-1) | Third | 1 out |
| Monday, April 14 |
| » Defeated Giants (3-3), 3-1 | Candlestick Park (1-0) | 3-2 | |
| » W: Sonny Siebert (1-0) L: Jim Barr (1-1) S: Bill Greif (2) | First | -- |
| » Major-league debuts: Dave Heaverlo (Giants) |
| Tuesday, April 15 |
| » Defeated Giants (3-4), 2-1 | Candlestick Park (2-0) | 4-2 | Won 2 |
| » W: Randy Jones (1-0) L: Mike Caldwell (0-2) S: Danny Frisella (1) | First | -- |
| Wednesday, April 16 |
| » Lost to Giants (4-4), 7-1 | Candlestick Park (2-1) | 4-3 | |
| » W: John D'Acquisto (1-1) L: Dan Spillner (1-1) | First | -- |
| Thursday, April 17 |
| » Major-league debuts: Bombo Rivera (Expos) |
| Friday, April 18 |
| » Defeated Braves (6-5), 3-1 | Atlanta-Fulton County Stadium (1-0) | 5-3 | |
| » W: Joe McIntosh (2-0) L: Ron Reed (0-3) S: Dave Tomlin (1) | First | -- |
| Saturday, April 19 |
| » Defeated Braves (6-6), 8-2 | Atlanta-Fulton County Stadium (2-0) | 6-3 | Won 2 |
| » W: Dave Freisleben (1-1) L: Gary Gentry (0-1) | First | -- |
| Sunday, April 20 |
| » Lost to Braves (7-6), 4-3 | Atlanta-Fulton County Stadium (2-1) | 6-4 | |
| » W: Tom House (1-1) L: Rich Folkers (0-2) | First | -- |
| Monday, April 21 |
| » Defeated Astros (4-10), 4-0 | Astrodome (1-0) | 7-4 | |
| » W: Randy Jones (2-0) L: Jim Crawford (0-1) | First | -- |
| Tuesday, April 22 |
| » Defeated Astros (4-11), 2-1 | Astrodome (2-0) | 8-4 | Won 2 |
| » W: Dan Spillner (2-1) L: Tom Griffin (0-3) | First | -- |
| Wednesday, April 23 |
| » Defeated Dodgers (8-8), 7-1 | San Diego/Jack Murphy Stadium (3-2) | 9-4 | Won 3 |
| » W: Joe McIntosh (3-0) L: Don Sutton (3-1) | First | -- |
| Thursday, April 24 |
| » Lost to Dodgers (9-8), 11-6 | San Diego/Jack Murphy Stadium (3-3) | 9-5 | |
| » W: Rick Rhoden (1-0) L: Dave Freisleben (1-2) S: Al Downing (1) | First | -- |
| Friday, April 25 |
| » Defeated Braves (9-9), 5-3 | San Diego/Jack Murphy Stadium (4-3) | 10-5 | |
| » W: Sonny Siebert (2-0) L: Buzz Capra (2-2) S: Bill Greif (3) | First | -- |
| » Major-league debuts: Biff Pocoroba (Braves) |
| Saturday, April 26 |
| » Lost to Braves (10-9), 6-4 | San Diego/Jack Murphy Stadium (4-4) | 10-6 | |
| » W: Carl Morton (5-0) L: Randy Jones (2-1) S: Tom House (1) | First | -- |
| Sunday, April 27 |
| » Lost to Braves (11-9), 12-8 | San Diego/Jack Murphy Stadium (4-5) | 10-7 | Lost 2 |
| » W: Ron Reed (2-3) L: Rich Folkers (0-3) | Third | 1 out |
| » Lost to Braves (12-9), 4-1 | San Diego/Jack Murphy Stadium (4-6) | 10-8 | Lost 3 |
| » W: Roric Harrison (1-0) L: Alan Foster (0-1) | Third | 1 out |
| Monday, April 28 |
| » Lost to Astros (7-15), 4-1 | San Diego/Jack Murphy Stadium (4-7) | 10-9 | Lost 4 |
| » W: Dave Roberts (2-2) L: Joe McIntosh (3-1) | Third | 2 out |
| Tuesday, April 29 |
| » Lost to Astros (8-15), 8-2 | San Diego/Jack Murphy Stadium (4-8) | 10-10 | Lost 5 |
| » W: J.R. Richard (2-1) L: Dave Freisleben (1-3) | Third | 3 out |
| Wednesday, April 30 |
| » Defeated Astros (8-16), 4-2 | San Diego/Jack Murphy Stadium (5-8) | 11-10 | |
| » W: Sonny Siebert (3-0) L: Larry Dierker (3-2) S: Bill Greif (4) | Second | 3 out |
| Thursday, May 1 |
| » Lost to Astros (9-16), 6-3 | San Diego/Jack Murphy Stadium (5-9) | 11-11 | |
| » W: Ken Forsch (1-2) L: Randy Jones (2-2) S: Jim Crawford (1) | Third | 3½ out |
| Friday, May 2 |
| » Lost to Dodgers (16-8), 3-0 | Dodger Stadium (0-1) | 11-12 | Lost 2 |
| » W: Don Sutton (5-1) L: Dan Spillner (2-2) | Fifth | 4½ out |
| Saturday, May 3 |
| » Defeated Dodgers (16-9), 3-1 | Dodger Stadium (1-1) | 12-12 | |
| » W: Alan Foster (1-1) L: Jim Brewer (1-1) | Fourth | 3½ out |
| Sunday, May 4 |
| » Defeated Dodgers (16-10), 10-7 | Dodger Stadium (2-1) | 13-12 | Won 2 |
| » W: Randy Jones (3-2) L: Burt Hooton (0-3) | Third | 2½ out |
| Tuesday, May 6 |
| » Lost to Reds (15-12), 7-3 | Riverfront Stadium (0-1) | 13-13 | |
| » W: Jack Billingham (3-1) L: Sonny Siebert (3-1) | Fourth | 4 out |
| Wednesday, May 7 |
| » Lost to Reds (16-12), 10-2 | Riverfront Stadium (0-2) | 13-14 | Lost 2 |
| » W: Fred Norman (2-1) L: Dan Spillner (2-3) S: Clay Carroll (1) | Fourth | 5 out |
| Thursday, May 8 |
| » Defeated Reds (16-13), 3-0 | Riverfront Stadium (1-2) | 14-14 | |
| » W: Randy Jones (4-2) L: Gary Nolan (1-2) | Fourth | 4½ out |
| Friday, May 9 |
| » Lost to Cubs (17-8), 5-2 | Wrigley Field (0-1) | 14-15 | |
| » W: Ray Burris (4-1) L: Joe McIntosh (3-2) S: Darold Knowles (6) | Fifth | 4½ out |
| Saturday, May 10 |
| » Lost to Cubs (18-8), 5-1 | Wrigley Field (0-2) | 14-16 | Lost 2 |
| » W: Rick Reuschel (2-3) L: Sonny Siebert (3-2) S: Geoff Zahn (1) | Fifth | 5½ out |
| Sunday, May 11 |
| » Defeated Cubs (18-9), 2-1 | Wrigley Field (1-2) | 15-16 | |
| » W: Dave Freisleben (2-3) L: Bill Bonham (3-2) | Fourth | 5½ out |
| Tuesday, May 13 |
| » Lost to Pirates (14-12), 2-0 | Three Rivers Stadium (0-1) | 15-17 | |
| » W: Jerry Reuss (3-2) L: Dan Spillner (2-4) | Fourth | 7 out |
| Wednesday, May 14 |
| » Lost to Pirates (15-12), 5-4 | Three Rivers Stadium (0-2) | 15-18 | Lost 2 |
| » W: Sam McDowell (1-1) L: Bill Greif (0-1) | Fourth | 7 out |
| Friday, May 16 |
| » Defeated Cubs (20-11), 8-2 | San Diego/Jack Murphy Stadium (6-9) | 16-18 | |
| » W: Joe McIntosh (4-2) L: Bill Bonham (3-3) | Third | 6 out |
| Saturday, May 17 |
| » Defeated Cubs (20-12), 4-1 | San Diego/Jack Murphy Stadium (7-9) | 17-18 | Won 2 |
| » W: Dave Freisleben (3-3) L: Darold Knowles (1-1) | Third | 6 out |
| Sunday, May 18 |
| » Lost to Cubs (21-12), 3-2 | San Diego/Jack Murphy Stadium (7-10) | 17-19 | |
| » W: Ray Burris (5-2) L: Dan Spillner (2-5) S: Oscar Zamora (5) | Third | 6 out |
| Monday, May 19 |
| » Defeated Cardinals (14-19), 1-0 | San Diego/Jack Murphy Stadium (8-10) | 18-19 | |
| » W: Randy Jones (5-2) L: Jack Curtis (2-2) | Third | 6 out |
| Tuesday, May 20 |
| » Defeated Cardinals (14-20), 5-2 | San Diego/Jack Murphy Stadium (9-10) | 19-19 | Won 2 |
| » W: Alan Foster (2-1) L: Elias Sosa (0-3) | Second | 5 out |
| Wednesday, May 21 |
| » Defeated Cardinals (14-21), 1-0 | San Diego/Jack Murphy Stadium (10-10) | 20-19 | Won 3 |
| » W: Joe McIntosh (5-2) L: Bob Gibson (1-4) | Second | 5 out |
| Thursday, May 22 |
| » Lost to Pirates (18-16), 4-2 | San Diego/Jack Murphy Stadium (10-11) | 20-20 | |
| » W: Jim Rooker (3-2) L: Dave Freisleben (3-4) S: Dave Giusti (4) | Fourth | 6 out |
| Friday, May 23 |
| » Defeated Pirates (18-17), 4-3 | San Diego/Jack Murphy Stadium (11-11) | 21-20 | |
| » W: Danny Frisella (1-0) L: Dave Giusti (2-2) | Fourth | 5 out |
| Saturday, May 24 |
| » Defeated Pirates (18-18), 5-0 | San Diego/Jack Murphy Stadium (12-11) | 22-20 | Won 2 |
| » W: Randy Jones (6-2) L: Jerry Reuss (3-4) | Fourth | 4 out |
| Sunday, May 25 |
| » Lost to Pirates (19-18), 6-5 | San Diego/Jack Murphy Stadium (12-12) | 22-21 | |
| » W: Ramon Hernandez (1-2) L: Danny Frisella (1-1) S: Larry Demery (1) | Fourth | 5 out |
| Monday, May 26 |
| » Defeated Cardinals (16-23), 9-6 | Busch Stadium II (1-0) | 23-21 | |
| » W: Bill Greif (1-1) L: Al Hrabosky (1-2) S: Danny Frisella (2) | Fourth | 4 out |
| Tuesday, May 27 |
| » Lost to Cardinals (17-23), 7-1 | Busch Stadium II (1-1) | 23-22 | |
| » W: Bob Forsch (5-3) L: Dave Freisleben (3-5) | Fourth | 5 out |
| Wednesday, May 28 |
| » Lost to Cardinals (18-23), 6-5 | Busch Stadium II (1-2) | 23-23 | Lost 2 |
| » W: Mike Garman (2-2) L: Bill Greif (1-2) | Fourth | 5 out |
| Friday, May 30 |
| » Defeated Mets (20-19), 6-2 | Shea Stadium (1-0) | 24-23 | |
| » W: Randy Jones (7-2) L: Jerry Koosman (4-3) | Fourth | 5 out |
| Saturday, May 31 |
| » Lost to Mets (21-19), 7-2 | Shea Stadium (1-1) | 24-24 | |
| » W: Tom Seaver (7-4) L: Joe McIntosh (5-3) | Fourth | 5 out |
| Sunday, June 1 |
| » Defeated Mets (21-20), 4-0 | Shea Stadium (2-1) | 25-24 | |
| » W: Alan Foster (3-1) L: Randy Tate (2-4) S: Danny Frisella (3) | Fourth | 4 out |
| Monday, June 2 |
| » Lost to Phillies (24-23), 5-1 | Veteran's Stadium (0-1) | 25-25 | |
| » W: Steve Carlton (4-5) L: Dave Freisleben (3-6) | Fourth | 4 out |
| Tuesday, June 3 |
| » Lost to Phillies (25-23), 12-1 | Veteran's Stadium (0-2) | 25-26 | Lost 2 |
| » W: Jim Lonborg (4-3) L: Dan Spillner (2-6) | Fourth | 5 out |
| Wednesday, June 4 |
| » Lost to Phillies (26-23), 7-2 | Veteran's Stadium (0-3) | 25-27 | Lost 3 |
| » W: Wayne Twitchell (4-6) L: Randy Jones (7-3) S: Tug McGraw (5) | Fourth | 6 out |
| Sunday, June 8 |
| » Defeated Expos (16-29), 5-2 | Parc Jarry (1-0) | 26-27 | |
| » W: Joe McIntosh (6-3) L: Dave McNally (3-6) | Fourth | 7 out |
| » Lost to Expos (17-29), 3-1 | Parc Jarry (1-1) | 26-28 | |
| » W: Steve Rogers (4-4) L: Dave Freisleben (3-7) | Fourth | 7 out |
| Monday, June 9 |
| » Defeated Phillies (28-25), 8-3 | San Diego/Jack Murphy Stadium (13-12) | 27-28 | |
| » W: Randy Jones (8-3) L: Wayne Twitchell (4-7) | Fourth | 6 out |
| Tuesday, June 10 |
| » Lost to Phillies (29-25), 7-0 | San Diego/Jack Murphy Stadium (13-13) | 27-29 | |
| » W: Larry Christenson (1-1) L: Dan Spillner (2-7) | Fourth | 6 out |
| Wednesday, June 11 |
| » Defeated Expos (18-31), 3-1 | San Diego/Jack Murphy Stadium (14-13) | 28-29 | |
| » W: Rich Folkers (1-3) L: Dennis Blair (2-8) S: Danny Frisella (4) | Fourth | 6 out |
| Thursday, June 12 |
| » Lost to Expos (19-31), 3-2 | San Diego/Jack Murphy Stadium (14-14) | 28-30 | |
| » W: Don DeMola (2-1) L: Danny Frisella (1-2) S: Steve Renko (1) | Fourth | 7 out |
| Friday, June 13 |
| » Lost to Mets (30-23), 7-2 | San Diego/Jack Murphy Stadium (14-15) | 28-31 | Lost 2 |
| » W: George Stone (1-0) L: Joe McIntosh (6-4) | Fourth | 8 out |
| Saturday, June 14 |
| » Defeated Mets (30-24), 7-1 | San Diego/Jack Murphy Stadium (15-15) | 29-31 | |
| » W: Randy Jones (9-3) L: Jerry Koosman (5-5) | Fourth | 8 out |
| Sunday, June 15 |
| » Lost to Mets (31-24), 6-0 | San Diego/Jack Murphy Stadium (15-16) | 29-32 | |
| » W: Tom Seaver (10-4) L: Brent Strom (0-1) | Third | 8 out |
| Monday, June 16 |
| » Defeated Giants (29-33), 7-1 | Candlestick Park (3-1) | 30-32 | |
| » W: Rich Folkers (2-3) L: Ed Halicki (2-3) | Third | 8 out |
| Tuesday, June 17 |
| » Lost to Giants (30-33), 3-1 | Candlestick Park (3-2) | 30-33 | |
| » W: Pete Falcone (5-5) L: Dave Freisleben (3-8) | Third | 8 out |
| Wednesday, June 18 |
| » Lost to Giants (31-33), 8-1 | Candlestick Park (3-3) | 30-34 | Lost 2 |
| » W: John Montefusco (4-3) L: Joe McIntosh (6-5) | Fourth | 9 out |
| Thursday, June 19 |
| » Lost to Dodgers (39-29), 4-1 | San Diego/Jack Murphy Stadium (15-17) | 30-35 | Lost 3 |
| » W: Doug Rau (6-6) L: Randy Jones (9-4) S: Mike Marshall (4) | Fourth | 9½ out |
| Friday, June 20 |
| » Defeated Dodgers (39-30), 2-1 | San Diego/Jack Murphy Stadium (16-17) | 31-35 | |
| » W: Brent Strom (1-1) L: Don Sutton (11-6) | Fourth | 9½ out |
| Saturday, June 21 |
| » Lost to Dodgers (40-30), 4-3 | San Diego/Jack Murphy Stadium (16-18) | 31-36 | |
| » W: Andy Messersmith (11-3) L: Rich Folkers (2-4) | Fourth | 10½ out |
| Sunday, June 22 |
| » Lost to Dodgers (41-30), 3-2 | San Diego/Jack Murphy Stadium (16-19) | 31-37 | Lost 2 |
| » W: Mike Marshall (3-5) L: Danny Frisella (1-3) | Fourth | 10½ out |
| Monday, June 23 |
| » Defeated Giants (33-36), 7-6 | San Diego/Jack Murphy Stadium (17-19) | 32-37 | |
| » W: Dave Tomlin (1-0) L: Gary Lavelle (4-2) S: Bill Greif (5) | Fourth | 10½ out |
| Tuesday, June 24 |
| » Defeated Giants (33-37), 2-1 | San Diego/Jack Murphy Stadium (18-19) | 33-37 | Won 2 |
| » W: Randy Jones (10-4) L: Gary Lavelle (4-3) | Third | 10 out |
| » Defeated Giants (33-38), 3-0 | San Diego/Jack Murphy Stadium (19-19) | 34-37 | Won 3 |
| » W: Brent Strom (2-1) L: Tom Bradley (0-1) | Third | 10 out |
| Wednesday, June 25 |
| » Defeated Giants (33-39), 6-2 | San Diego/Jack Murphy Stadium (20-19) | 35-37 | Won 4 |
| » W: Rich Folkers (3-4) L: Mike Caldwell (4-7) | Third | 10 out |
| Thursday, June 26 |
| Future Padre Jason Middlebrook is born in Jackson, MI. |
| Friday, June 27 |
| » Lost to Reds (46-27), 5-2 | Riverfront Stadium (1-3) | 35-38 | |
| » W: Will McEnaney (2-0) L: Danny Frisella (1-4) | Third | 11 out |
| Saturday, June 28 |
| » Lost to Reds (47-27), 6-4 | Riverfront Stadium (1-4) | 35-39 | Lost 2 |
| » W: Will McEnaney (3-0) L: Dave Tomlin (1-1) | Fourth | 12 out |
| Sunday, June 29 |
| » Lost to Reds (48-27), 4-1 | Riverfront Stadium (1-5) | 35-40 | Lost 3 |
| » W: Jack Billingham (9-3) L: Randy Jones (10-5) S: Will McEnaney (7) | Fourth | 12 out |
| » Defeated Reds (48-28), 4-3 | Riverfront Stadium (2-5) | 36-40 | |
| » W: Brent Strom (3-1) L: Pat Darcy (2-5) | Fourth | 12 out |
| Monday, June 30 |
| » Lost to Dodgers (43-36), 4-1 | Dodger Stadium (2-2) | 36-41 | |
| » W: Andy Messersmith (12-4) L: Rich Folkers (3-5) | Fourth | 13 out |
| Tuesday, July 1 |
| » Defeated Dodgers (43-37), 10-1 | Dodger Stadium (3-2) | 37-41 | |
| » W: Dan Spillner (3-7) L: Burt Hooton (6-8) | Fourth | 13 out |
| Wednesday, July 2 |
| » Lost to Dodgers (44-37), 6-5 | Dodger Stadium (3-3) | 37-42 | |
| » W: Al Downing (1-0) L: Joe McIntosh (6-6) | Fourth | 14 out |
| Thursday, July 3 |
| » Defeated Reds (51-29), 2-1 | San Diego/Jack Murphy Stadium (21-19) | 38-42 | |
| » W: Randy Jones (11-5) L: Will McEnaney (3-1) | Fourth | 13 out |
| Friday, July 4 |
| » Lost to Reds (52-29), 7-6 | San Diego/Jack Murphy Stadium (21-20) | 38-43 | |
| » W: Jack Billingham (10-3) L: Rich Folkers (3-6) S: Will McEnaney (8) | Fourth | 14 out |
| Saturday, July 5 |
| » Lost to Reds (53-29), 6-3 | San Diego/Jack Murphy Stadium (21-21) | 38-44 | Lost 2 |
| » W: Fred Norman (4-3) L: Brent Strom (3-2) S: Rawly Eastwick (3) | Fourth | 15 out |
| Sunday, July 6 |
| » Lost to Reds (54-29), 13-2 | San Diego/Jack Murphy Stadium (21-22) | 38-45 | Lost 3 |
| » W: Clay Kirby (6-3) L: Joe McIntosh (6-7) S: Pedro Borbon (3) | Fourth | 16 out |
| Tuesday, July 8 |
| » Defeated Cubs (39-47), 8-6 | Wrigley Field (2-2) | 39-45 | |
| » W: Joe McIntosh (7-7) L: Tom Dettore (2-2) | Fourth | 16½ out |
| Wednesday, July 9 |
| » Defeated Cubs (39-48), 3-2 | Wrigley Field (3-2) | 40-45 | Won 2 |
| » W: Brent Strom (4-2) L: Geoff Zahn (2-7) S: Bill Greif (6) | Third | 16½ out |
| Thursday, July 10 |
| » Lost to Cubs (40-48), 3-1 | Wrigley Field (3-3) | 40-46 | |
| » W: Ray Burris (8-6) L: Dave Freisleben (3-9) | Fourth | 17 out |
| Friday, July 11 |
| » Lost to Pirates (53-32), 6-2 | Three Rivers Stadium (0-3) | 40-47 | Lost 2 |
| » W: Jim Rooker (7-4) L: Rich Folkers (3-7) S: Dave Giusti (11) | Fourth | 19 out |
| » Lost to Pirates (54-32), 5-0 | Three Rivers Stadium (0-4) | 40-48 | Lost 3 |
| » W: John Candelaria (4-1) L: Joe McIntosh (7-8) | Fourth | 19 out |
| Saturday, July 12 |
| » Lost to Pirates (55-32), 6-4 | Three Rivers Stadium (0-5) | 40-49 | Lost 4 |
| » W: Ramon Hernandez (6-2) L: Randy Jones (11-6) S: Larry Demery (3) | Fourth | 20 out |
| Sunday, July 13 |
| » Defeated Pirates (55-33), 7-5 | Three Rivers Stadium (1-5) | 41-49 | |
| » W: Brent Strom (5-2) L: Dock Ellis (6-6) S: Dan Spillner (1) | Fourth | 20 out |
| Thursday, July 17 |
| » Lost to Cubs (43-49), 6-5 | San Diego/Jack Murphy Stadium (21-23) | 41-50 | |
| » W: Rick Reuschel (6-10) L: Brent Strom (5-3) S: Darold Knowles (9) | Fourth | 20 out |
| Friday, July 18 |
| » Defeated Cubs (43-50), 4-2 | San Diego/Jack Murphy Stadium (22-23) | 42-50 | |
| » W: Bill Greif (2-2) L: Milt Wilcox (0-1) S: Danny Frisella (5) | Fourth | 20 out |
| Saturday, July 19 |
| » Defeated Cubs (43-51), 2-1 | San Diego/Jack Murphy Stadium (23-23) | 43-50 | Won 2 |
| » W: Dave Freisleben (4-9) L: Steve Stone (7-4) | Fourth | 19 out |
| Sunday, July 20 |
| » Lost to Cardinals (44-46), 3-1 | San Diego/Jack Murphy Stadium (23-24) | 43-51 | |
| » W: Al Hrabosky (7-2) L: Bill Greif (2-3) | Fourth | 19½ out |
| » Lost to Cardinals (45-46), 10-2 | San Diego/Jack Murphy Stadium (23-25) | 43-52 | Lost 2 |
| » W: Jack Curtis (6-7) L: Rich Folkers (3-8) | Fourth | 19½ out |
| Monday, July 21 |
| » Lost to Cardinals (46-46), 4-0 | San Diego/Jack Murphy Stadium (23-26) | 43-53 | Lost 3 |
| » W: Eric Rasmussen (1-0) L: Brent Strom (5-4) | Fifth | 20½ out |
| » Major-league debuts: Eric Rasmussen (Cardinals) |
| Tuesday, July 22 |
| » Defeated Pirates (58-37), 1-0 | San Diego/Jack Murphy Stadium (24-26) | 44-53 | |
| » W: Randy Jones (12-6) L: Bruce Kison (9-5) | Fourth | 19½ out |
| Wednesday, July 23 |
| » Lost to Pirates (59-37), 8-1 | San Diego/Jack Murphy Stadium (24-27) | 44-54 | |
| » W: Dock Ellis (7-6) L: Dave Freisleben (4-10) | Fourth | 19½ out |
| Friday, July 25 |
| » Defeated Braves (44-55), 7-3 | Atlanta-Fulton County Stadium (3-1) | 45-54 | |
| » W: Joe McIntosh (8-8) L: Ray Sadecki (3-2) S: Bill Greif (7) | Fourth | 19 out |
| » Defeated Braves (44-56), 8-1 | Atlanta-Fulton County Stadium (4-1) | 46-54 | Won 2 |
| » W: Dan Spillner (4-7) L: Mike Thompson (0-3) | Fourth | 19 out |
| Saturday, July 26 |
| » Defeated Braves (44-57), 4-2 | Atlanta-Fulton County Stadium (5-1) | 47-54 | Won 3 |
| » W: Jerry Johnson (1-0) L: Carl Morton (12-11) S: Danny Frisella (6) | Fourth | 19 out |
| Future Padre Kevin Barker is born in Bristol, VA. |
| Sunday, July 27 |
| » Defeated Braves (44-58), 3-1 | Atlanta-Fulton County Stadium (6-1) | 48-54 | Won 4 |
| » W: Randy Jones (13-6) L: Bruce Dal Canton (0-5) | Fourth | 18 out |
| Monday, July 28 |
| » Defeated Astros (36-69), 2-0 | Astrodome (3-0) | 49-54 | Won 5 |
| » W: Dave Freisleben (5-10) L: Larry Dierker (9-11) | Fourth | 18 out |
| Tuesday, July 29 |
| » Lost to Astros (37-69), 6-2 | Astrodome (3-1) | 49-55 | |
| » W: Dave Roberts (6-11) L: Dan Spillner (4-8) | Fourth | 18 out |
| Wednesday, July 30 |
| » Lost to Astros (38-69), 8-4 | Astrodome (3-2) | 49-56 | Lost 2 |
| » W: Doug Konieczny (5-11) L: Joe McIntosh (8-9) S: Jose Sosa (1) | Fourth | 19 out |
| Thursday, July 31 |
| » Defeated Astros (38-70), 5-3 | Astrodome (4-2) | 50-56 | |
| » W: Dave Tomlin (2-1) L: Wayne Granger (2-4) S: Bill Greif (8) | Fourth | 19 out |
| Friday, August 1 |
| » Defeated Braves (47-60), 4-0 | San Diego/Jack Murphy Stadium (25-27) | 51-56 | Won 2 |
| » W: Randy Jones (14-6) L: Phil Niekro (11-8) | Fourth | 18 out |
| Saturday, August 2 |
| » Lost to Braves (48-60), 8-6 | San Diego/Jack Murphy Stadium (25-28) | 51-57 | |
| » W: Mike Beard (4-0) L: Joe McIntosh (8-10) | Fourth | 19 out |
| Sunday, August 3 |
| » Lost to Braves (49-60), 5-1 | San Diego/Jack Murphy Stadium (25-29) | 51-58 | Lost 2 |
| » W: Carl Morton (13-12) L: Dan Spillner (4-9) | Fourth | 20 out |
| Monday, August 4 |
| » Lost to Astros (40-73), 5-3 | San Diego/Jack Murphy Stadium (25-30) | 51-59 | Lost 3 |
| » W: Joe Niekro (3-4) L: Dave Freisleben (5-11) S: Mike Cosgrove (3) | Fourth | 21 out |
| Tuesday, August 5 |
| » Defeated Astros (40-74), 6-5 | San Diego/Jack Murphy Stadium (26-30) | 52-59 | |
| » W: Bill Greif (3-3) L: Wayne Granger (2-5) | Fourth | 21 out |
| Wednesday, August 6 |
| » Defeated Astros (40-75), 6-1 | San Diego/Jack Murphy Stadium (27-30) | 53-59 | Won 2 |
| » W: Randy Jones (15-6) L: Larry Dierker (9-12) | Fourth | 21 out |
| Friday, August 8 |
| » Lost to Cardinals (58-54), 10-6 | Busch Stadium II (1-3) | 53-60 | |
| » W: Bob Forsch (11-8) L: Dan Spillner (4-10) | Fourth | 21 out |
| Saturday, August 9 |
| » Lost to Cardinals (59-54), 6-1 | Busch Stadium II (1-4) | 53-61 | Lost 2 |
| » W: Lynn McGlothen (12-8) L: Dave Freisleben (5-12) | Fourth | 22 out |
| Sunday, August 10 |
| » Lost to Cardinals (60-54), 3-2 | Busch Stadium II (1-5) | 53-62 | Lost 3 |
| » W: Al Hrabosky (10-3) L: Bill Greif (3-4) | Fourth | 23 out |
| Monday, August 11 |
| » Lost to Mets (59-56), 8-4 | Shea Stadium (2-2) | 53-63 | Lost 4 |
| » W: Skip Lockwood (1-0) L: Randy Jones (15-7) | Fourth | 24 out |
| Tuesday, August 12 |
| » Lost to Mets (60-56), 9-4 | Shea Stadium (2-3) | 53-64 | Lost 5 |
| » W: Tom Seaver (16-7) L: Jerry Johnson (1-1) | Fourth | 25 out |
| Wednesday, August 13 |
| » Defeated Mets (60-57), 8-5 | Shea Stadium (3-3) | 54-64 | |
| » W: Rich Folkers (4-8) L: Randy Tate (4-11) | Fourth | 24½ out |
| Friday, August 15 |
| » Lost to Phillies (65-54), 4-3 | Veteran's Stadium (0-4) | 54-65 | |
| » W: Tom Hilgendorf (3-3) L: Joe McIntosh (8-11) S: Tug McGraw (10) | Fourth | 26 out |
| Saturday, August 16 |
| » Defeated Phillies (65-55), 5-1 | Veteran's Stadium (1-4) | 55-65 | |
| » W: Randy Jones (16-7) L: Tug McGraw (7-5) | Fourth | 26 out |
| Sunday, August 17 |
| » Lost to Phillies (66-55), 10-4 | Veteran's Stadium (1-5) | 55-66 | |
| » W: Tom Underwood (12-8) L: Dave Freisleben (5-13) S: Gene Garber (9) | Fourth | 27 out |
| Monday, August 18 |
| » Lost to Expos (51-69), 4-1 | Parc Jarry (1-2) | 55-67 | Lost 2 |
| » W: Dan Warthen (6-4) L: Dave Tomlin (2-2) S: Dale Murray (7) | Fourth | 27½ out |
| » Defeated Expos (51-70), 5-2 | Parc Jarry (2-2) | 56-67 | |
| » W: Rich Folkers (5-8) L: Woodie Fryman (8-8) | Fourth | 27½ out |
| Tuesday, August 19 |
| » Lost to Expos (52-70), 5-0 | Parc Jarry (2-3) | 56-68 | |
| » W: Steve Rogers (10-9) L: Joe McIntosh (8-12) | Fourth | 27½ out |
| Wednesday, August 20 |
| » Defeated Expos (52-71), 8-6 | Parc Jarry (3-3) | 57-68 | |
| » W: Jerry Johnson (2-1) L: Woodie Fryman (8-9) S: Danny Frisella (7) | Fourth | 26½ out |
| Friday, August 22 |
| » Lost to Phillies (69-56), 6-5 | San Diego/Jack Murphy Stadium (27-31) | 57-69 | |
| » W: Tom Hilgendorf (5-3) L: Bill Greif (3-5) S: Gene Garber (10) | Fourth | 26 out |
| Saturday, August 23 |
| » Defeated Phillies (69-57), 8-3 | San Diego/Jack Murphy Stadium (28-31) | 58-69 | |
| » W: Dan Spillner (5-10) L: Steve Carlton (11-10) S: Danny Frisella (8) | Fourth | 26 out |
| Sunday, August 24 |
| » Defeated Phillies (69-58), 7-2 | San Diego/Jack Murphy Stadium (29-31) | 59-69 | Won 2 |
| » W: Randy Jones (17-7) L: Dick Ruthven (1-2) | Fourth | 24½ out |
| » Defeated Phillies (69-59), 7-6 | San Diego/Jack Murphy Stadium (30-31) | 60-69 | Won 3 |
| » W: Bill Greif (4-5) L: Ron Schueler (4-4) | Fourth | 24½ out |
| Monday, August 25 |
| » Lost to Mets (67-62), 4-0 | San Diego/Jack Murphy Stadium (30-32) | 60-70 | |
| » W: Hank Webb (6-5) L: Brent Strom (5-5) | Fourth | 25½ out |
| Tuesday, August 26 |
| » Lost to Mets (68-62), 7-2 | San Diego/Jack Murphy Stadium (30-33) | 60-71 | Lost 2 |
| » W: Randy Tate (5-12) L: Dave Freisleben (5-14) | Fourth | 26½ out |
| Wednesday, August 27 |
| » Lost to Mets (69-62), 7-0 | San Diego/Jack Murphy Stadium (30-34) | 60-72 | Lost 3 |
| » W: Tom Seaver (19-7) L: Dan Spillner (5-11) | Fourth | 27½ out |
| Thursday, August 28 |
| » Lost to Expos (56-74), 10-8 | San Diego/Jack Murphy Stadium (30-35) | 60-73 | Lost 4 |
| » W: Fred Scherman (3-4) L: Randy Jones (17-8) S: Dale Murray (8) | Fourth | 28½ out |
| Friday, August 29 |
| » Lost to Expos (57-74), 4-0 | San Diego/Jack Murphy Stadium (30-36) | 60-74 | Lost 5 |
| » W: Don Carrithers (2-1) L: Joe McIntosh (8-13) | Fourth | 29½ out |
| Saturday, August 30 |
| » Lost to Expos (58-74), 5-1 | San Diego/Jack Murphy Stadium (30-37) | 60-75 | Lost 6 |
| » W: Steve Renko (5-10) L: Rich Folkers (5-9) | Fourth | 30½ out |
| Sunday, August 31 |
| » Defeated Expos (58-75), 6-0 | San Diego/Jack Murphy Stadium (31-37) | 61-75 | |
| » W: Brent Strom (6-5) L: Dan Warthen (6-6) | Fourth | 29½ out |
| Monday, September 1 |
| » Defeated Reds (90-46), 2-1 | Riverfront Stadium (3-5) | 62-75 | Won 2 |
| » W: Randy Jones (18-8) L: Pedro Borbon (8-5) | Fourth | 28½ out |
| Tuesday, September 2 |
| » Lost to Reds (91-46), 10-4 | Riverfront Stadium (3-6) | 62-76 | |
| » W: Don Gullett (12-3) L: Dan Spillner (5-12) | Fourth | 29½ out |
| Wednesday, September 3 |
| » Defeated Braves (60-79), 10-9 | Atlanta-Fulton County Stadium (7-1) | 63-76 | |
| » W: Jerry Johnson (3-1) L: Tom House (7-5) S: Bill Greif (9) | Fourth | 29½ out |
| Thursday, September 4 |
| » Lost to Braves (61-79), 2-1 | Atlanta-Fulton County Stadium (7-2) | 63-77 | |
| » W: Bruce Dal Canton (1-7) L: Danny Frisella (1-5) | Fourth | 29½ out |
| Friday, September 5 |
| » Lost to Astros (54-88), 2-1 | Astrodome (4-3) | 63-78 | Lost 2 |
| » W: J.R. Richard (10-9) L: Randy Jones (18-9) | Fourth | 30½ out |
| Saturday, September 6 |
| » Defeated Astros (54-89), 2-1 | Astrodome (5-3) | 64-78 | |
| » W: Brent Strom (7-5) L: Doug Konieczny (6-13) | Fourth | 30½ out |
| Future Padre Derrek Lee is born in Sacramento, CA. |
| Sunday, September 7 |
| » Lost to Astros (55-89), 3-2 | Astrodome (5-4) | 64-79 | |
| » W: Jim York (3-3) L: Danny Frisella (1-6) | Fourth | 31½ out |
| Monday, September 8 |
| » Lost to Reds (96-47), 3-2 | San Diego/Jack Murphy Stadium (31-38) | 64-80 | Lost 2 |
| » W: Clay Carroll (7-5) L: Bill Greif (4-6) S: Rawly Eastwick (18) | Fourth | 32½ out |
| Tuesday, September 9 |
| » Defeated Reds (96-48), 11-2 | San Diego/Jack Murphy Stadium (32-38) | 65-80 | |
| » W: Rich Folkers (6-9) L: Clay Kirby (9-6) | Fourth | 31½ out |
| Wednesday, September 10 |
| » Defeated Braves (64-82), 2-1 | San Diego/Jack Murphy Stadium (33-38) | 66-80 | Won 2 |
| » W: Randy Jones (19-9) L: Bruce Dal Canton (2-8) | Fourth | 30½ out |
| Thursday, September 11 |
| » Defeated Braves (64-83), 4-3 | San Diego/Jack Murphy Stadium (34-38) | 67-80 | Won 3 |
| » W: Brent Strom (8-5) L: Tom House (7-6) | Fourth | 29½ out |
| Friday, September 12 |
| » Defeated Astros (58-91), 1-0 | San Diego/Jack Murphy Stadium (35-38) | 68-80 | Won 4 |
| » W: Dave Tomlin (3-2) L: Jim York (3-4) | Fourth | 29½ out |
| Sunday, September 14 |
| » Lost to Astros (59-91), 4-2 | San Diego/Jack Murphy Stadium (35-39) | 68-81 | |
| » W: J.R. Richard (11-9) L: Randy Jones (19-10) S: Joe Niekro (4) | Fourth | 29½ out |
| Monday, September 15 |
| » Lost to Dodgers (82-69), 5-4 | Dodger Stadium (3-4) | 68-82 | Lost 2 |
| » W: Burt Hooton (17-9) L: Joe McIntosh (8-14) | Fourth | 30 out |
| Future Padre Javier Cardona is born in Santurce, P.R. |
| Tuesday, September 16 |
| » Lost to Dodgers (83-69), 5-2 | Dodger Stadium (3-5) | 68-83 | Lost 3 |
| » W: Rick Rhoden (3-2) L: Brent Strom (8-6) S: Charlie Hough (4) | Fourth | 30 out |
| Wednesday, September 17 |
| » Lost to Dodgers (84-69), 7-1 | Dodger Stadium (3-6) | 68-84 | Lost 4 |
| » W: Andy Messersmith (18-14) L: |