| Monday, April 7 |
| » Major-league debuts: Jerry Remy (Angels) |
| Tuesday, April 8 |
| » Major-league debuts: Jim Umbarger (Rangers) Lyman Bostock (Twins) |
| Thursday, April 10 |
| » Defeated Tigers (0-1), 10-0 | Tiger Stadium (1-0) | 1-0 | |
| » W: Jim Palmer (1-0) L: Joe Coleman (0-1) | First | -- |
| Friday, April 11 |
| » Lost to Red Sox (2-1), 6-5 | Memorial Stadium (0-1) | 1-1 | |
| » W: Diego Segui (1-0) L: Doyle Alexander (0-1) | Second | ½ out |
| Saturday, April 12 |
| » Lost to Red Sox (3-1), 3-2 | Memorial Stadium (0-2) | 1-2 | Lost 2 |
| » W: Reggie Cleveland (1-0) L: Jesse Jefferson (0-1) S: Dick Drago (1) | Third | 1½ out |
| Sunday, April 13 |
| » Defeated Red Sox (3-2), 11-3 | Memorial Stadium (1-2) | 2-2 | |
| » W: Mike Torrez (1-0) L: Luis Tiant (1-1) | Second | ½ out |
| Monday, April 14 |
| » Major-league debuts: Dave Heaverlo (Giants) |
| Tuesday, April 15 |
| » Lost to Brewers (4-2), 7-1 | Memorial Stadium (1-3) | 2-3 | |
| » W: Bill Champion (2-0) L: Jim Palmer (1-1) | Fourth | 1½ out |
| Wednesday, April 16 |
| » Defeated Brewers (4-3), 2-0 | Memorial Stadium (2-3) | 3-3 | |
| » W: Mike Cuellar (1-0) L: Jim Slaton (1-2) | Fifth | 1½ out |
| Thursday, April 17 |
| » Major-league debuts: Bombo Rivera (Expos) |
| Friday, April 18 |
| » Defeated Red Sox (5-3), 9-7 | Fenway Park (1-0) | 4-3 | Won 2 |
| » W: Doyle Alexander (1-1) L: Reggie Cleveland (1-1) | Second | ½ out |
| Sunday, April 20 |
| » Lost to Red Sox (6-3), 10-2 | Fenway Park (1-1) | 4-4 | |
| » W: Luis Tiant (2-1) L: Mike Torrez (1-1) | Third | 1½ out |
| Tuesday, April 22 |
| » Defeated Brewers (6-5), 1-0 | County Stadium (1-0) | 5-4 | |
| » W: Jim Palmer (2-1) L: Pete Broberg (2-2) | First | -- |
| Wednesday, April 23 |
| » Lost to Brewers (7-5), 8-5 | County Stadium (1-1) | 5-5 | |
| » W: Eduardo Rodriguez (1-0) L: Bob Reynolds (0-1) S: Tom Murphy (5) | Second | 1 out |
| Saturday, April 26 |
| » Lost to Indians (5-5), 3-0 | Memorial Stadium (2-4) | 5-6 | Lost 2 |
| » W: Gaylord Perry (3-2) L: Ross Grimsley (0-1) | Third | 1 out |
| » Defeated Indians (5-6), 3-2 | Memorial Stadium (3-4) | 6-6 | |
| » W: Mike Torrez (2-1) L: Dick Bosman (0-1) | Third | 1 out |
| Sunday, April 27 |
| » Defeated Indians (5-7), 6-1 | Memorial Stadium (4-4) | 7-6 | Won 2 |
| » W: Jim Palmer (3-1) L: Jim Perry (1-3) | Second | 1 out |
| Monday, April 28 |
| » Lost to Tigers (9-5), 5-3 | Memorial Stadium (4-5) | 7-7 | |
| » W: Joe Coleman (1-3) L: Mike Cuellar (1-1) S: John Hiller (3) | Third | 2 out |
| Tuesday, April 29 |
| » Lost to Tigers (10-5), 4-2 | Memorial Stadium (4-6) | 7-8 | Lost 2 |
| » W: Tom Walker (1-1) L: Ross Grimsley (0-2) | Third | 3 out |
| Wednesday, April 30 |
| » Lost to Yankees (9-10), 6-4 | Shea Stadium (0-1) | 7-9 | Lost 3 |
| » W: Sparky Lyle (1-1) L: Grant Jackson (0-1) | Fifth | 3 out |
| Thursday, May 1 |
| » Lost to Yankees (10-10), 5-0 | Shea Stadium (0-2) | 7-10 | Lost 4 |
| » W: Catfish Hunter (2-3) L: Jim Palmer (3-2) | Fifth | 3 out |
| Friday, May 2 |
| » Lost to Indians (8-9), 4-3 | Cleveland Stadium (0-1) | 7-11 | Lost 5 |
| » W: Dennis Eckersley (1-0) L: Dave Johnson (0-1) S: Tom Buskey (3) | Fifth | 4 out |
| Saturday, May 3 |
| » Lost to Indians (9-9), 6-1 | Cleveland Stadium (0-2) | 7-12 | Lost 6 |
| » W: Fritz Peterson (2-2) L: Ross Grimsley (0-3) | Fifth | 5 out |
| Future Oriole Gabe Molina is born in Denver, CO. |
| Sunday, May 4 |
| » Defeated Indians (9-10), 11-1 | Cleveland Stadium (1-2) | 8-12 | |
| » W: Mike Torrez (3-1) L: Gaylord Perry (4-3) | Sixth | 5½ out |
| » Lost to Indians (10-10), 4-3 | Cleveland Stadium (1-3) | 8-13 | |
| » W: Tom Buskey (1-0) L: Jesse Jefferson (0-2) | Sixth | 5½ out |
| Monday, May 5 |
| » Defeated Yankees (10-14), 3-1 | Memorial Stadium (5-6) | 9-13 | |
| » W: Jim Palmer (4-2) L: Catfish Hunter (2-4) | Sixth | 5 out |
| Wednesday, May 7 |
| » Defeated Yankees (10-15), 4-3 | Memorial Stadium (6-6) | 10-13 | Won 2 |
| » W: Mike Cuellar (2-1) L: Doc Medich (3-4) | Fourth | 4½ out |
| Friday, May 9 |
| » Lost to Twins (11-11), 5-2 | Memorial Stadium (6-7) | 10-14 | |
| » W: Jim Hughes (2-1) L: Ross Grimsley (0-4) | Fourth | 5 out |
| Saturday, May 10 |
| » Defeated Twins (11-12), 8-6 | Memorial Stadium (7-7) | 11-14 | |
| » W: Mike Torrez (4-1) L: Ray Corbin (0-2) | Fourth | 5 out |
| Sunday, May 11 |
| » Lost to Twins (12-12), 6-4 | Memorial Stadium (7-8) | 11-15 | |
| » W: Bert Blyleven (4-1) L: Mike Cuellar (2-2) | Fourth | 4½ out |
| » Defeated Twins (12-13), 9-3 | Memorial Stadium (8-8) | 12-15 | |
| » W: Jim Palmer (5-2) L: Mike Pazik (0-1) | Fourth | 4½ out |
| Tuesday, May 13 |
| » Defeated White Sox (12-18), 3-2 | Memorial Stadium (9-8) | 13-15 | Won 2 |
| » W: Ross Grimsley (1-4) L: Jim Kaat (5-1) | Fourth | 3½ out |
| Wednesday, May 14 |
| » Defeated White Sox (12-19), 3-2 | Memorial Stadium (10-8) | 14-15 | Won 3 |
| » W: Mike Torrez (5-1) L: Terry Forster (2-3) | Third | 3 out |
| Friday, May 16 |
| » Defeated Angels (16-18), 1-0 | Memorial Stadium (11-8) | 15-15 | Won 4 |
| » W: Jim Palmer (6-2) L: Frank Tanana (2-1) | Third | 4½ out |
| » Lost to Angels (17-18), 3-2 | Memorial Stadium (11-9) | 15-16 | |
| » W: Ed Figueroa (2-0) L: Mike Cuellar (2-3) | Third | 4½ out |
| Saturday, May 17 |
| » Lost to Angels (18-18), 6-3 | Memorial Stadium (11-10) | 15-17 | Lost 2 |
| » W: Bill Singer (3-5) L: Wayne Garland (0-1) | Third | 4½ out |
| Sunday, May 18 |
| » Lost to Angels (19-18), 5-1 | Memorial Stadium (11-11) | 15-18 | Lost 3 |
| » W: Nolan Ryan (8-1) L: Mike Torrez (5-2) S: Don Kirkwood (3) | Fourth | 4½ out |
| Monday, May 19 |
| » Lost to White Sox (15-20), 2-1 | Comiskey Park I (0-1) | 15-19 | Lost 4 |
| » W: Stan Bahnsen (1-4) L: Doyle Alexander (1-2) S: Rich Gossage (6) | Fourth | 5 out |
| Wednesday, May 21 |
| » Defeated White Sox (15-21), 6-2 | Comiskey Park I (1-1) | 16-19 | |
| » W: Jim Palmer (7-2) L: Claude Osteen (1-4) | Fourth | 4½ out |
| Thursday, May 22 |
| » Lost to White Sox (16-21), 2-1 | Comiskey Park I (1-2) | 16-20 | |
| » W: Jim Kaat (7-1) L: Mike Cuellar (2-4) S: Rich Gossage (7) | Fourth | 4½ out |
| Friday, May 23 |
| » Lost to Royals (22-19), 10-1 | Royals Stadium (0-1) | 16-21 | Lost 2 |
| » W: Al Fitzmorris (6-3) L: Ross Grimsley (1-5) | Fourth | 4½ out |
| Saturday, May 24 |
| » Lost to Royals (23-19), 5-4 | Royals Stadium (0-2) | 16-22 | Lost 3 |
| » W: Marty Pattin (1-0) L: Wayne Garland (0-2) | Fifth | 5 out |
| Sunday, May 25 |
| » Lost to Royals (24-19), 9-1 | Royals Stadium (0-3) | 16-23 | Lost 4 |
| » W: Steve Busby (7-3) L: Jim Palmer (7-3) | Fifth | 5 out |
| Monday, May 26 |
| » Lost to Athletics (25-17), 6-5 | Oakland-Alameda County Stadium (0-1) | 16-24 | Lost 5 |
| » W: Rollie Fingers (5-2) L: Doyle Alexander (1-3) | Sixth | 6 out |
| Tuesday, May 27 |
| » Lost to Athletics (26-17), 4-2 | Oakland-Alameda County Stadium (0-2) | 16-25 | Lost 6 |
| » W: Jim Todd (1-1) L: Ross Grimsley (1-6) | Sixth | 6½ out |
| Wednesday, May 28 |
| » Lost to Athletics (27-17), 5-0 | Oakland-Alameda County Stadium (0-3) | 16-26 | Lost 7 |
| » W: Vida Blue (9-2) L: Mike Torrez (5-3) | Sixth | 7½ out |
| Friday, May 30 |
| » Defeated Angels (22-25), 5-0 | Anaheim Stadium (1-0) | 17-26 | |
| » W: Jim Palmer (8-3) L: Ed Figueroa (3-1) | Sixth | 6½ out |
| Saturday, May 31 |
| » Defeated Angels (22-26), 1-0 | Anaheim Stadium (2-0) | 18-26 | Won 2 |
| » W: Mike Cuellar (3-4) L: Bill Singer (4-7) | Sixth | 6½ out |
| Sunday, June 1 |
| » Lost to Angels (23-26), 1-0 | Anaheim Stadium (2-1) | 18-27 | |
| » W: Nolan Ryan (9-3) L: Ross Grimsley (1-7) | Sixth | 7½ out |
| Tuesday, June 3 |
| » Defeated Rangers (23-25), 6-3 | Memorial Stadium (12-11) | 19-27 | |
| » W: Mike Torrez (6-3) L: Steve Hargan (4-3) | Sixth | 7 out |
| Wednesday, June 4 |
| » Lost to Rangers (24-25), 3-2 | Memorial Stadium (12-12) | 19-28 | |
| » W: Jackie Brown (4-5) L: Grant Jackson (0-2) | Sixth | 8 out |
| Friday, June 6 |
| » Defeated Royals (30-23), 3-2 | Memorial Stadium (13-12) | 20-28 | |
| » W: Grant Jackson (1-2) L: Marty Pattin (3-2) | Sixth | 8 out |
| Saturday, June 7 |
| » Defeated Royals (30-24), 7-3 | Memorial Stadium (14-12) | 21-28 | Won 2 |
| » W: Mike Torrez (7-3) L: Dennis Leonard (2-2) | Sixth | 8 out |
| Sunday, June 8 |
| » Defeated Royals (30-25), 1-0 | Memorial Stadium (15-12) | 22-28 | Won 3 |
| » W: Jim Palmer (9-3) L: Steve Busby (7-5) | Sixth | 7 out |
| Monday, June 9 |
| » Lost to Athletics (32-22), 4-3 | Memorial Stadium (15-13) | 22-29 | |
| » W: Paul Lindblad (4-0) L: Dyar Miller (0-1) S: Vida Blue (1) | Sixth | 7 out |
| » Major-league debuts: Dyar Miller (Orioles) |
| Tuesday, June 10 |
| » Lost to Athletics (33-22), 3-0 | Memorial Stadium (15-14) | 22-30 | Lost 2 |
| » W: Jim Perry (2-7) L: Ross Grimsley (1-8) | Sixth | 7 out |
| Wednesday, June 11 |
| » Defeated Rangers (28-28), 9-8 | Arlington Stadium (1-0) | 23-30 | |
| » W: Dyar Miller (1-1) L: Stan Thomas (3-1) | Fifth | 7 out |
| Thursday, June 12 |
| » Defeated Rangers (28-29), 7-1 | Arlington Stadium (2-0) | 24-30 | Won 2 |
| » W: Jim Palmer (10-3) L: Jim Bibby (2-6) | Fifth | 6 out |
| Friday, June 13 |
| » Lost to Twins (27-26), 7-3 | Metropolitan Stadium (0-1) | 24-31 | |
| » W: Dave Goltz (6-5) L: Mike Cuellar (3-5) | Fifth | 6½ out |
| Saturday, June 14 |
| » Defeated Twins (27-27), 7-0 | Metropolitan Stadium (1-1) | 25-31 | |
| » W: Ross Grimsley (2-8) L: Jim Hughes (6-4) | Fifth | 6½ out |
| Sunday, June 15 |
| » Lost to Twins (28-27), 5-4 | Metropolitan Stadium (1-2) | 25-32 | |
| » W: Ray Corbin (3-3) L: Mike Torrez (7-4) | Fifth | 7½ out |
| Monday, June 16 |
| » Defeated Indians (24-35), 8-3 | Cleveland Stadium (2-3) | 26-32 | |
| » W: Jim Palmer (11-3) L: Jim Bibby (2-7) S: Grant Jackson (1) | Fourth | 7½ out |
| Tuesday, June 17 |
| » Defeated Indians (24-36), 5-3 | Cleveland Stadium (3-3) | 27-32 | Won 2 |
| » W: Mike Cuellar (4-5) L: Eric Raich (2-2) S: Doyle Alexander (1) | Fourth | 7½ out |
| Wednesday, June 18 |
| » Defeated Indians (24-37), 13-6 | Cleveland Stadium (4-3) | 28-32 | Won 3 |
| » W: Ross Grimsley (3-8) L: Fritz Peterson (4-7) | Fourth | 7½ out |
| Thursday, June 19 |
| Future Oriole Willis Roberts is born in San Cristobal, D.R. |
| Friday, June 20 |
| » Lost to Red Sox (36-24), 4-3 | Memorial Stadium (15-15) | 28-33 | |
| » W: Dick Drago (1-0) L: Dyar Miller (1-2) | Fourth | 8½ out |
| Saturday, June 21 |
| » Defeated Red Sox (36-25), 3-0 | Memorial Stadium (16-15) | 29-33 | |
| » W: Jim Palmer (12-3) L: Dick Pole (1-3) | Fourth | 7½ out |
| Sunday, June 22 |
| » Defeated Red Sox (36-26), 3-0 | Memorial Stadium (17-15) | 30-33 | Won 2 |
| » W: Mike Cuellar (5-5) L: Rick Wise (7-6) | Fourth | 7½ out |
| » Lost to Red Sox (37-26), 5-1 | Memorial Stadium (17-16) | 30-34 | |
| » W: Luis Tiant (10-6) L: Doyle Alexander (1-4) | Fourth | 7½ out |
| » Major-league debuts: Royle Stillman (Orioles) |
| Future Oriole Esteban Yan is born in Campina Del Seibo, D.R. |
| Monday, June 23 |
| » Lost to Yankees (38-29), 6-1 | Memorial Stadium (17-17) | 30-35 | Lost 2 |
| » W: Doc Medich (6-9) L: Ross Grimsley (3-9) | Fourth | 7½ out |
| Tuesday, June 24 |
| » Lost to Yankees (39-29), 3-1 | Memorial Stadium (17-18) | 30-36 | Lost 3 |
| » W: Catfish Hunter (11-6) L: Mike Torrez (7-5) | Fourth | 8 out |
| Wednesday, June 25 |
| » Lost to Yankees (40-29), 2-1 | Memorial Stadium (17-19) | 30-37 | Lost 4 |
| » W: Sparky Lyle (2-5) L: Jim Palmer (12-4) | Fourth | 9 out |
| Thursday, June 26 |
| » Lost to Tigers (27-40), 6-5 | Memorial Stadium (17-20) | 30-38 | Lost 5 |
| » W: Mickey Lolich (8-5) L: Doyle Alexander (1-5) | Fourth | 9 out |
| Friday, June 27 |
| » Defeated Tigers (27-41), 3-2 | Memorial Stadium (18-20) | 31-38 | |
| » W: Ross Grimsley (4-9) L: John Hiller (2-3) | Fourth | 8½ out |
| Saturday, June 28 |
| » Defeated Tigers (27-42), 7-4 | Memorial Stadium (19-20) | 32-38 | Won 2 |
| » W: Mike Torrez (8-5) L: Joe Coleman (3-12) S: Grant Jackson (2) | Fourth | 8 out |
| » Major-league debuts: Fernando Arroyo (Tigers) |
| Sunday, June 29 |
| » Defeated Tigers (27-43), 2-1 | Memorial Stadium (20-20) | 33-38 | Won 3 |
| » W: Mike Cuellar (6-5) L: Ray Bare (2-5) | Fourth | 7½ out |
| Monday, June 30 |
| » Lost to Red Sox (41-30), 5-2 | Fenway Park (1-2) | 33-39 | |
| » W: Dick Pole (2-4) L: Jim Palmer (12-5) S: Diego Segui (5) | Fourth | 7½ out |
| » Defeated Red Sox (41-31), 8-2 | Fenway Park (2-2) | 34-39 | |
| » W: Doyle Alexander (2-5) L: Luis Tiant (11-7) S: Grant Jackson (3) | Fourth | 7½ out |
| Tuesday, July 1 |
| » Defeated Red Sox (41-32), 10-6 | Fenway Park (3-2) | 35-39 | Won 2 |
| » W: Grant Jackson (2-2) L: Reggie Cleveland (4-5) | Third | 6½ out |
| » Major-league debuts: Paul Mitchell (Orioles) |
| Wednesday, July 2 |
| » Defeated Tigers (28-46), 13-5 | Tiger Stadium (2-0) | 36-39 | Won 3 |
| » W: Mike Torrez (9-5) L: Tom Walker (2-6) | Fourth | 6 out |
| Thursday, July 3 |
| » Lost to Tigers (29-46), 9-5 | Tiger Stadium (2-1) | 36-40 | |
| » W: Joe Coleman (4-12) L: Wayne Garland (0-3) | Fourth | 6 out |
| Friday, July 4 |
| » Defeated Yankees (41-37), 5-4 | Shea Stadium (1-2) | 37-40 | |
| » W: Jim Palmer (13-5) L: Catfish Hunter (11-8) S: Grant Jackson (4) | Fourth | 5 out |
| Saturday, July 5 |
| » Defeated Yankees (41-38), 5-2 | Shea Stadium (2-2) | 38-40 | Won 2 |
| » W: Ross Grimsley (5-9) L: Rudy May (7-5) | Fourth | 4 out |
| Sunday, July 6 |
| » Lost to Yankees (42-38), 6-1 | Shea Stadium (2-3) | 38-41 | |
| » W: Pat Dobson (9-7) L: Mike Cuellar (6-6) | Fourth | 4½ out |
| Tuesday, July 8 |
| » Defeated Angels (39-47), 8-5 | Anaheim Stadium (3-1) | 39-41 | |
| » W: Doyle Alexander (3-5) L: Nolan Ryan (10-8) S: Grant Jackson (5) | Fourth | 5 out |
| Wednesday, July 9 |
| » Lost to Angels (40-47), 3-2 | Anaheim Stadium (3-2) | 39-42 | |
| » W: Frank Tanana (7-5) L: Ross Grimsley (5-10) S: Don Kirkwood (6) | Fourth | 6 out |
| Thursday, July 10 |
| » Defeated Angels (40-48), 7-3 | Anaheim Stadium (4-2) | 40-42 | |
| » W: Mike Cuellar (7-6) L: Ed Figueroa (7-5) | Fourth | 6 out |
| Friday, July 11 |
| » Defeated Athletics (53-32), 4-0 | Oakland-Alameda County Stadium (1-3) | 41-42 | Won 2 |
| » W: Mike Torrez (10-5) L: Vida Blue (12-7) | Third | 6 out |
| Saturday, July 12 |
| » Lost to Athletics (54-32), 7-1 | Oakland-Alameda County Stadium (1-4) | 41-43 | |
| » W: Jim Perry (4-7) L: Jim Palmer (13-6) | Fourth | 7 out |
| Sunday, July 13 |
| » Lost to Athletics (55-32), 4-3 | Oakland-Alameda County Stadium (1-5) | 41-44 | Lost 2 |
| » W: Ken Holtzman (11-7) L: Ross Grimsley (5-11) S: Rollie Fingers (12) | Fourth | 8 out |
| Thursday, July 17 |
| » Defeated Twins (39-50), 6-3 | Memorial Stadium (21-20) | 42-44 | |
| » W: Grant Jackson (3-2) L: Bill Campbell (2-5) | Fourth | 8 out |
| Friday, July 18 |
| » Defeated Twins (39-51), 9-6 | Memorial Stadium (22-20) | 43-44 | Won 2 |
| » W: Mike Cuellar (8-6) L: Dave Goltz (7-7) S: Dyar Miller (1) | Fourth | 8 out |
| Saturday, July 19 |
| » Defeated Athletics (57-33), 3-2 | Memorial Stadium (23-20) | 44-44 | Won 3 |
| » W: Paul Mitchell (1-0) L: Vida Blue (12-8) | Fourth | 7½ out |
| » Defeated Athletics (57-34), 5-1 | Memorial Stadium (24-20) | 45-44 | Won 4 |
| » W: Ross Grimsley (6-11) L: Jim Perry (4-8) S: Jim Palmer (1) | Fourth | 7½ out |
| Sunday, July 20 |
| » Lost to Athletics (58-34), 5-2 | Memorial Stadium (24-21) | 45-45 | |
| » W: Rollie Fingers (6-4) L: Doyle Alexander (3-6) | Fourth | 8 out |
| Monday, July 21 |
| » Defeated Athletics (58-35), 6-2 | Memorial Stadium (25-21) | 46-45 | |
| » W: Mike Torrez (11-5) L: Ken Holtzman (12-8) S: Wayne Garland (1) | Fourth | 7 out |
| Tuesday, July 22 |
| » Defeated Angels (43-55), 8-3 | Memorial Stadium (26-21) | 47-45 | Won 2 |
| » W: Mike Cuellar (9-6) L: Nolan Ryan (10-11) | Third | 7 out |
| Wednesday, July 23 |
| » Lost to Angels (44-55), 1-0 | Memorial Stadium (26-22) | 47-46 | |
| » W: Frank Tanana (9-5) L: Jim Palmer (13-7) | Fourth | 8 out |
| Thursday, July 24 |
| » Defeated Brewers (49-49), 10-7 | County Stadium (2-1) | 48-46 | |
| » W: Wayne Garland (1-3) L: Pete Broberg (9-10) S: Dyar Miller (2) | Second | 8 out |
| Friday, July 25 |
| » Lost to Brewers (50-49), 5-2 | County Stadium (2-2) | 48-47 | |
| » W: Jim Colborn (6-8) L: Mike Torrez (11-6) | Fourth | 8 out |
| Saturday, July 26 |
| » Defeated Brewers (50-50), 4-0 | County Stadium (3-2) | 49-47 | |
| » W: Mike Cuellar (10-6) L: Jim Slaton (9-10) | Third | 8 out |
| Sunday, July 27 |
| » Defeated Brewers (50-51), 7-4 | County Stadium (4-2) | 50-47 | Won 2 |
| » W: Jim Palmer (14-7) L: Lafayette Currence (0-1) S: Dyar Miller (3) | Second | 8 out |
| » Defeated Brewers (50-52), 11-6 | County Stadium (5-2) | 51-47 | Won 3 |
| » W: Dyar Miller (2-2) L: Rick Austin (2-1) | Second | 8 out |
| Monday, July 28 |
| » Lost to Indians (45-54), 7-5 | Memorial Stadium (26-23) | 51-48 | |
| » W: Rick Waits (1-0) L: Doyle Alexander (3-7) S: Fred Beene (1) | Second | 9 out |
| Future Oriole Chad Paronto is born in Haverhill, NH. |
| Tuesday, July 29 |
| » Defeated Indians (45-55), 7-1 | Memorial Stadium (27-23) | 52-48 | |
| » W: Mike Torrez (12-6) L: Don Hood (3-7) | Second | 8 out |
| Wednesday, July 30 |
| » Lost to Indians (46-55), 3-1 | Memorial Stadium (27-24) | 52-49 | |
| » W: Dennis Eckersley (8-3) L: Mike Cuellar (10-7) | Second | 8 out |
| Friday, August 1 |
| » Defeated Brewers (52-54), 6-4 | Memorial Stadium (28-24) | 53-49 | |
| » W: Jim Palmer (15-7) L: Bill Champion (6-6) S: Wayne Garland (2) | Second | 8½ out |
| » Defeated Brewers (52-55), 3-1 | Memorial Stadium (29-24) | 54-49 | Won 2 |
| » W: Ross Grimsley (7-11) L: Tom Hausman (3-3) | Second | 8½ out |
| Saturday, August 2 |
| » Defeated Brewers (52-56), 6-1 | Memorial Stadium (30-24) | 55-49 | Won 3 |
| » W: Mike Torrez (13-6) L: Jim Colborn (7-9) | Second | 8½ out |
| Sunday, August 3 |
| » Lost to Brewers (53-56), 4-1 | Memorial Stadium (30-25) | 55-50 | |
| » W: Jim Slaton (11-10) L: Mike Cuellar (10-8) | Second | 9½ out |
| Monday, August 4 |
| » Defeated Red Sox (66-43), 12-8 | Fenway Park (4-2) | 56-50 | |
| » W: Doyle Alexander (4-7) L: Jim Willoughby (2-1) S: Dyar Miller (4) | Second | 8½ out |
| Tuesday, August 5 |
| » Defeated Red Sox (66-44), 3-0 | Fenway Park (5-2) | 57-50 | Won 2 |
| » W: Jim Palmer (16-7) L: Luis Tiant (13-11) | Second | 7½ out |
| Wednesday, August 6 |
| » Defeated Tigers (46-65), 4-2 | Tiger Stadium (3-1) | 58-50 | Won 3 |
| » W: Mike Torrez (14-6) L: Lerrin LaGrow (7-11) S: Wayne Garland (3) | Second | 7 out |
| » Defeated Tigers (46-66), 8-2 | Tiger Stadium (4-1) | 59-50 | Won 4 |
| » W: Ross Grimsley (8-11) L: Dave Lemanczyk (0-4) S: Dyar Miller (5) | Second | 7 out |
| Thursday, August 7 |
| » Defeated Tigers (46-67), 7-6 | Tiger Stadium (5-1) | 60-50 | Won 5 |
| » W: Dyar Miller (3-2) L: Bob Reynolds (0-3) | Second | 7 out |
| Future Oriole Geronimo Gil is born in Oaxaca, Mexico. |
| Friday, August 8 |
| » Defeated White Sox (55-58), 7-4 | Comiskey Park I (2-2) | 61-50 | Won 6 |
| » W: Doyle Alexander (5-7) L: Wilbur Wood (12-14) S: Dyar Miller (6) | Second | 6 out |
| Saturday, August 9 |
| » Defeated White Sox (55-59), 12-6 | Comiskey Park I (3-2) | 62-50 | Won 7 |
| » W: Jim Palmer (17-7) L: Claude Osteen (6-11) | Second | 6 out |
| Sunday, August 10 |
| » Lost to White Sox (56-59), 3-2 | Comiskey Park I (3-3) | 62-51 | |
| » W: Rich Gossage (6-6) L: Grant Jackson (3-3) | Second | 7 out |
| Monday, August 11 |
| » Defeated Royals (64-51), 4-0 | Memorial Stadium (31-25) | 63-51 | |
| » W: Mike Cuellar (11-8) L: Steve Busby (15-9) | Second | 6 out |
| Tuesday, August 12 |
| » Lost to Royals (65-51), 4-2 | Memorial Stadium (31-26) | 63-52 | |
| » W: Doug Bird (8-4) L: Dyar Miller (3-3) | Second | 7 out |
| Wednesday, August 13 |
| » Defeated Royals (65-52), 3-0 | Memorial Stadium (32-26) | 64-52 | |
| » W: Jim Palmer (18-7) L: Marty Pattin (8-8) | Second | 6 out |
| » Major-league debuts: Bob McClure (Royals) |
| Friday, August 15 |
| » Lost to Rangers (59-61), 10-6 | Memorial Stadium (32-27) | 64-53 | |
| » W: Steve Foucault (5-2) L: Wayne Garland (1-4) | Second | 6 out |
| » Defeated Rangers (59-62), 13-1 | Memorial Stadium (33-27) | 65-53 | |
| » W: Mike Cuellar (12-8) L: Clyde Wright (3-5) | Second | 6 out |
| Saturday, August 16 |
| » Lost to Rangers (60-62), 5-1 | Memorial Stadium (33-28) | 65-54 | |
| » W: Gaylord Perry (13-15) L: Ross Grimsley (8-12) | Second | 7 out |
| Sunday, August 17 |
| » Defeated Rangers (60-63), 4-0 | Memorial Stadium (34-28) | 66-54 | |
| » W: Jim Palmer (19-7) L: Stan Perzanowski (1-2) | Second | 6½ out |
| Monday, August 18 |
| » Lost to Twins (57-67), 6-1 | Metropolitan Stadium (1-3) | 66-55 | |
| » W: Dave Goltz (11-10) L: Mike Torrez (14-7) | Second | 7 out |
| Tuesday, August 19 |
| » Lost to Twins (58-67), 5-2 | Metropolitan Stadium (1-4) | 66-56 | Lost 2 |
| » W: Bert Blyleven (13-6) L: Mike Cuellar (12-9) | Second | 8 out |
| Wednesday, August 20 |
| » Defeated Twins (58-68), 3-2 | Metropolitan Stadium (2-4) | 67-56 | |
| » W: Ross Grimsley (9-12) L: Jim Hughes (11-11) | Second | 7 out |
| Thursday, August 21 |
| » Defeated Rangers (61-66), 4-2 | Arlington Stadium (3-0) | 68-56 | Won 2 |
| » W: Dyar Miller (4-3) L: Steve Foucault (5-3) | Second | 6½ out |
| Friday, August 22 |
| » Defeated Rangers (61-67), 8-5 | Arlington Stadium (4-0) | 69-56 | Won 3 |
| » W: Mike Torrez (15-7) L: Stan Perzanowski (1-3) S: Grant Jackson (6) | Second | 6½ out |
| Saturday, August 23 |
| » Lost to Rangers (62-67), 1-0 | Arlington Stadium (4-1) | 69-57 | |
| » W: Fergie Jenkins (15-13) L: Mike Cuellar (12-10) | Second | 6½ out |
| Sunday, August 24 |
| » Lost to Rangers (63-67), 8-7 | Arlington Stadium (4-2) | 69-58 | Lost 2 |
| » W: Steve Foucault (6-3) L: Wayne Garland (1-5) | Second | 7½ out |
| Tuesday, August 26 |
| » Lost to Royals (70-57), 4-3 | Royals Stadium (0-4) | 69-59 | Lost 3 |
| » W: Dennis Leonard (10-5) L: Jim Palmer (19-8) S: Doug Bird (11) | Second | 7 out |
| » Defeated Royals (70-58), 3-2 | Royals Stadium (1-4) | 70-59 | |
| » W: Doyle Alexander (6-7) L: Steve Busby (15-10) S: Grant Jackson (7) | Second | 7 out |
| Wednesday, August 27 |
| » Defeated Royals (70-59), 4-2 | Royals Stadium (2-4) | 71-59 | Won 2 |
| » W: Mike Torrez (16-7) L: Paul Splittorff (6-8) | Second | 7 out |
| Thursday, August 28 |
| » Defeated White Sox (64-68), 2-1 | Memorial Stadium (35-28) | 72-59 | Won 3 |
| » W: Mike Cuellar (13-10) L: Wilbur Wood (13-18) | Second | 6½ out |
| Friday, August 29 |
| » Lost to White Sox (65-68), 4-2 | Memorial Stadium (35-29) | 72-60 | |
| » W: Jim Kaat (19-10) L: Ross Grimsley (9-13) S: Rich Gossage (22) | Second | 7½ out |
| Saturday, August 30 |
| » Defeated White Sox (65-69), 4-2 | Memorial Stadium (36-29) | 73-60 | |
| » W: Jim Palmer (20-8) L: Jesse Jefferson (4-9) | Second | 6½ out |
| Tuesday, September 2 |
| » Defeated Indians (61-69), 3-2 | Memorial Stadium (37-29) | 74-60 | Won 2 |
| » W: Mike Cuellar (14-10) L: Bob Reynolds (0-4) | Second | 6 out |
| » Lost to Indians (62-69), 2-1 | Memorial Stadium (37-30) | 74-61 | |
| » W: Jim Bibby (5-14) L: Doyle Alexander (6-8) S: Dave LaRoche (13) | Second | 6 out |
| Wednesday, September 3 |
| » Lost to Red Sox (81-55), 3-2 | Memorial Stadium (37-31) | 74-62 | Lost 2 |
| » W: Rick Wise (18-8) L: Jim Palmer (20-9) | Second | 7 out |
| Thursday, September 4 |
| » Lost to Red Sox (82-55), 3-1 | Memorial Stadium (37-32) | 74-63 | Lost 3 |
| » W: Dick Pole (3-4) L: Mike Torrez (16-8) S: Dick Drago (10) | Second | 8 out |
| Friday, September 5 |
| » Defeated Yankees (70-69), 5-4 | Memorial Stadium (38-32) | 75-63 | |
| » W: Paul Mitchell (2-0) L: Doc Medich (12-16) | Second | 6½ out |
| » Defeated Yankees (70-70), 2-1 | Memorial Stadium (39-32) | 76-63 | Won 2 |
| » W: Ross Grimsley (10-13) L: Larry Gura (5-6) | Second | 6½ out |
| » Major-league debuts: Mike Flanagan (Orioles) |
| Saturday, September 6 |
| » Defeated Yankees (70-71), 7-6 | Memorial Stadium (40-32) | 77-63 | Won 3 |
| » W: Grant Jackson (4-3) L: Sparky Lyle (4-7) | Second | 6½ out |
| » Major-league debuts: Bob Bailor (Orioles) |
| Sunday, September 7 |
| » Lost to Yankees (71-71), 2-0 | Memorial Stadium (40-33) | 77-64 | |
| » W: Catfish Hunter (20-13) L: Jim Palmer (20-10) | Second | 7 out |
| Monday, September 8 |
| » Defeated Brewers (62-82), 6-2 | County Stadium (6-2) | 78-64 | |
| » W: Mike Torrez (17-8) L: Jim Slaton (11-18) | Second | 6 out |
| Tuesday, September 9 |
| » Defeated Brewers (62-83), 9-1 | County Stadium (7-2) | 79-64 | Won 2 |
| » W: Doyle Alexander (7-8) L: Pete Broberg (12-14) | Second | 5 out |
| » Major-league debuts: Jerry Augustine (Brewers) |
| Wednesday, September 10 |
| » Lost to Indians (70-70), 7-1 | Cleveland Stadium (4-4) | 79-65 | |
| » W: Dennis Eckersley (12-5) L: Mike Cuellar (14-11) S: Dave LaRoche (15) | Second | 5 out |
| » Defeated Indians (70-71), 6-5 | Cleveland Stadium (5-4) | 80-65 | |
| » W: Dyar Miller (5-3) L: Bob Reynolds (0-5) S: Wayne Garland (4) | Second | 5 out |
| Thursday, September 11 |
| » Defeated Indians (70-72), 10-2 | Cleveland Stadium (6-4) | 81-65 | Won 2 |
| » W: Jim Palmer (21-10) L: Roric Harrison (10-10) | Second | 5 out |
| Friday, September 12 |
| » Defeated Tigers (55-92), 6-4 | Tiger Stadium (6-1) | 82-65 | Won 3 |
| » W: Mike Torrez (18-8) L: Joe Coleman (9-17) S: Dyar Miller (7) | Second | 4½ out |
| Saturday, September 13 |
| » Defeated Tigers (55-93), 8-0 | Tiger Stadium (7-1) | 83-65 | Won 4 |
| » W: Doyle Alexander (8-8) L: Mickey Lolich (11-18) | Second | 4 out |
| Sunday, September 14 |
| » Defeated Tigers (55-94), 9-3 | Tiger Stadium (8-1) | 84-65 | Won 5 |
| » W: Paul Mitchell (3-0) L: Ray Bare (8-12) | Second | 4 out |
| Tuesday, September 16 |
| » Lost to Red Sox (90-61), 2-0 | Fenway Park (5-3) | 84-66 | |
| » W: Luis Tiant (17-13) L: Jim Palmer (21-11) | Second | 5½ out |
| Wednesday, September 17 |
| » Defeated Red Sox (90-62), 5-2 | Fenway Park (6-3) | 85-66 | |
| » W: Mike Torrez (19-8) L: Rick Wise (18-11) S: Dyar Miller (8) | Second | 4½ out |
| Thursday, September 18 |
| » Major-league debuts: Jerry Manuel and Bob Molinaro (Tigers) |
| Friday, September 19 |
| » Defeated Brewers (64-90), 6-5 | Memorial Stadium (41-33) | 86-66 | Won 2 |
| » W: Dyar Miller (6-3) L: Tom Murphy (1-8) | Second | 4½ out |
| Saturday, September 20 |
| » Defeated Brewers (64-91), 5-4 | Memorial Stadium (42-33) | 87-66 | Won 3 |
| » W: Wayne Garland (2-5) < |