| Sunday, February 23 |
| Future Indian Dave Maurer is born in Minneapolis, MN. |
| Monday, April 7 |
| » Major-league debuts: Jerry Remy (Angels) |
| Tuesday, April 8 |
| » Defeated Yankees (0-1), 5-3 | Cleveland Stadium (1-0) | 1-0 | |
| » W: Gaylord Perry (1-0) L: Doc Medich (0-1) | First | -- |
| Thursday, April 10 |
| » Major-league debuts: Rick Baldwin (Mets) |
| Friday, April 11 |
| » Lost to Brewers (2-1), 6-2 | County Stadium (0-1) | 1-1 | |
| » W: Bill Champion (1-0) L: Jim Perry (0-1) S: Tom Murphy (2) | Second | ½ out |
| Saturday, April 12 |
| » Lost to Brewers (3-1), 6-5 | County Stadium (0-2) | 1-2 | Lost 2 |
| » W: Jim Slaton (1-1) L: Fritz Peterson (0-1) S: Tom Murphy (3) | Third | 1½ out |
| » Major-league debuts: Dennis Eckersley (Indians) |
| Sunday, April 13 |
| » Defeated Brewers (3-2), 3-1 | County Stadium (1-2) | 2-2 | |
| » W: Gaylord Perry (2-0) L: Pete Broberg (1-1) | Second | ½ out |
| Monday, April 14 |
| » Major-league debuts: Randy Tate (Mets) |
| Friday, April 18 |
| » Lost to Brewers (5-3), 5-1 | Cleveland Stadium (1-1) | 2-3 | |
| » W: Pete Broberg (2-1) L: Gaylord Perry (2-1) S: Tom Murphy (4) | Fourth | 1½ out |
| Saturday, April 19 |
| » Lost to Brewers (6-3), 3-0 | Cleveland Stadium (1-2) | 2-4 | Lost 2 |
| » W: Bill Champion (3-0) L: Jim Perry (0-2) | Fourth | 2½ out |
| Sunday, April 20 |
| » Defeated Brewers (6-4), 7-4 | Cleveland Stadium (2-2) | 3-4 | |
| » W: Fritz Peterson (1-1) L: Jim Slaton (1-3) S: Tom Buskey (1) | Fourth | 2 out |
| Tuesday, April 22 |
| » Lost to Tigers (5-4), 6-2 | Tiger Stadium (0-1) | 3-5 | |
| » W: Lerrin LaGrow (2-0) L: Gaylord Perry (2-2) | Fourth | 1½ out |
| Wednesday, April 23 |
| » Defeated Tigers (5-5), 4-3 | Tiger Stadium (1-1) | 4-5 | |
| » W: Jim Perry (1-2) L: Joe Coleman (0-3) S: Tom Buskey (2) | Third | 1½ out |
| Saturday, April 26 |
| » Defeated Orioles (5-6), 3-0 | Memorial Stadium (1-0) | 5-5 | Won 2 |
| » W: Gaylord Perry (3-2) L: Ross Grimsley (0-1) | Fifth | 1½ out |
| » Lost to Orioles (6-6), 3-2 | Memorial Stadium (1-1) | 5-6 | |
| » W: Mike Torrez (2-1) L: Dick Bosman (0-1) | Fifth | 1½ out |
| Sunday, April 27 |
| » Lost to Orioles (7-6), 6-1 | Memorial Stadium (1-2) | 5-7 | Lost 2 |
| » W: Jim Palmer (3-1) L: Jim Perry (1-3) | Sixth | 2½ out |
| Monday, April 28 |
| » Lost to Yankees (8-9), 6-1 | Shea Stadium (0-1) | 5-8 | Lost 3 |
| » W: Rudy May (2-1) L: Fritz Peterson (1-2) | Sixth | 3½ out |
| Tuesday, April 29 |
| » Defeated Yankees (8-10), 3-1 | Shea Stadium (1-1) | 6-8 | |
| » W: Don Hood (1-0) L: Larry Gura (0-1) | Fifth | 3½ out |
| Future Indian Rafael Betancourt is born in Cumana, Venezuela. |
| Wednesday, April 30 |
| » Defeated Red Sox (7-9), 8-1 | Fenway Park (1-0) | 7-8 | Won 2 |
| » W: Gaylord Perry (4-2) L: Luis Tiant (2-3) | Fourth | 2½ out |
| Thursday, May 1 |
| » Lost to Red Sox (8-9), 7-6 | Fenway Park (1-1) | 7-9 | |
| » W: Bill Lee (2-3) L: Jim Perry (1-4) S: Diego Segui (2) | Fourth | 2½ out |
| Friday, May 2 |
| » Defeated Orioles (7-11), 4-3 | Cleveland Stadium (3-2) | 8-9 | |
| » W: Dennis Eckersley (1-0) L: Dave Johnson (0-1) S: Tom Buskey (3) | Fourth | 2½ out |
| Saturday, May 3 |
| » Defeated Orioles (7-12), 6-1 | Cleveland Stadium (4-2) | 9-9 | Won 2 |
| » W: Fritz Peterson (2-2) L: Ross Grimsley (0-3) | Third | 2½ out |
| Sunday, May 4 |
| » Lost to Orioles (8-12), 11-1 | Cleveland Stadium (4-3) | 9-10 | |
| » W: Mike Torrez (3-1) L: Gaylord Perry (4-3) | Fourth | 3 out |
| » Defeated Orioles (8-13), 4-3 | Cleveland Stadium (5-3) | 10-10 | |
| » W: Tom Buskey (1-0) L: Jesse Jefferson (0-2) | Fourth | 3 out |
| Monday, May 5 |
| » Lost to Red Sox (10-9), 7-5 | Cleveland Stadium (5-4) | 10-11 | |
| » W: Luis Tiant (3-3) L: Jim Perry (1-5) S: Dick Drago (2) | Fourth | 3½ out |
| Tuesday, May 6 |
| » Lost to Red Sox (11-9), 4-1 | Cleveland Stadium (5-5) | 10-12 | Lost 2 |
| » W: Bill Lee (3-3) L: Dick Bosman (0-2) | Fourth | 3½ out |
| Wednesday, May 7 |
| » Lost to Red Sox (12-9), 4-2 | Cleveland Stadium (5-6) | 10-13 | Lost 3 |
| » W: Reggie Cleveland (2-1) L: Fritz Peterson (2-3) S: Diego Segui (3) | Fourth | 4½ out |
| Friday, May 9 |
| » Lost to White Sox (11-16), 2-0 | Cleveland Stadium (5-7) | 10-14 | Lost 4 |
| » W: Jim Kaat (5-0) L: Gaylord Perry (4-4) S: Terry Forster (4) | Fourth | 5 out |
| Saturday, May 10 |
| » Lost to White Sox (12-16), 8-3 | Cleveland Stadium (5-8) | 10-15 | Lost 5 |
| » W: Wilbur Wood (2-6) L: Don Hood (1-1) S: Rich Gossage (5) | Sixth | 6 out |
| Sunday, May 11 |
| » Defeated White Sox (12-17), 4-3 | Cleveland Stadium (6-8) | 11-15 | |
| » W: Tom Buskey (2-0) L: Terry Forster (2-2) | Fifth | 5 out |
| Tuesday, May 13 |
| » Defeated Twins (12-14), 3-2 | Metropolitan Stadium (1-0) | 12-15 | Won 2 |
| » W: Fritz Peterson (3-3) L: Vic Albury (2-2) S: Dennis Eckersley (1) | Fifth | 4 out |
| Wednesday, May 14 |
| » Lost to Twins (13-14), 3-0 | Metropolitan Stadium (1-1) | 12-16 | |
| » W: Jim Hughes (3-1) L: Gaylord Perry (4-5) | Fifth | 4½ out |
| Thursday, May 15 |
| » Lost to Twins (14-14), 7-6 | Metropolitan Stadium (1-2) | 12-17 | Lost 2 |
| » W: Tom Burgmeier (2-1) L: Jim Perry (1-6) | Fifth | 6 out |
| Future Indian Steve Woodard is born in Hartselle, AL. |
| Friday, May 16 |
| » Lost to White Sox (13-19), 3-2 | Comiskey Park I (0-1) | 12-18 | Lost 3 |
| » W: Rich Gossage (2-2) L: Tom Buskey (2-1) | Fifth | 7 out |
| Saturday, May 17 |
| » Lost to White Sox (14-19), 10-1 | Comiskey Park I (0-2) | 12-19 | Lost 4 |
| » W: Jim Kaat (6-1) L: Fritz Peterson (3-4) | Fourth | 7 out |
| Sunday, May 18 |
| » Defeated White Sox (14-20), 7-6 | Comiskey Park I (1-2) | 13-19 | |
| » W: Gaylord Perry (5-5) L: Wilbur Wood (2-7) S: Dennis Eckersley (2) | Fifth | 6 out |
| Monday, May 19 |
| » Lost to Angels (20-18), 12-5 | Cleveland Stadium (6-9) | 13-20 | |
| » W: Dick Lange (1-1) L: Don Hood (1-2) | Sixth | 6½ out |
| Wednesday, May 21 |
| » Defeated Angels (20-19), 3-2 | Cleveland Stadium (7-9) | 14-20 | |
| » W: Jim Kern (1-0) L: Frank Tanana (2-2) S: Tom Buskey (4) | Sixth | 6 out |
| Friday, May 23 |
| » Lost to Athletics (22-16), 3-0 | Cleveland Stadium (7-10) | 14-21 | |
| » W: Sonny Siebert (4-2) L: Gaylord Perry (5-6) S: Jim Todd (5) | Fifth | 5½ out |
| » Major-league debuts: Rick Manning (Indians) |
| Saturday, May 24 |
| » Lost to Athletics (23-16), 10-5 | Cleveland Stadium (7-11) | 14-22 | Lost 2 |
| » W: Rollie Fingers (4-2) L: Don Hood (1-3) | Sixth | 6 out |
| Sunday, May 25 |
| » Defeated Athletics (23-17), 6-0 | Cleveland Stadium (8-11) | 15-22 | |
| » W: Dennis Eckersley (2-0) L: Jim Perry (1-7) | Sixth | 5½ out |
| » Lost to Athletics (24-17), 6-3 | Cleveland Stadium (8-12) | 15-23 | |
| » W: Dick Bosman (1-2) L: Jim Kern (1-1) S: Jim Todd (6) | Sixth | 5½ out |
| Monday, May 26 |
| » Defeated Angels (22-22), 9-3 | Anaheim Stadium (1-0) | 16-23 | |
| » Manager: Dave Garcia |
| » W: Fritz Peterson (4-4) L: Frank Tanana (2-3) | Fifth | 5½ out |
| Tuesday, May 27 |
| » Defeated Angels (22-23), 6-3 | Anaheim Stadium (2-0) | 17-23 | Won 2 |
| » W: Gaylord Perry (6-6) L: Bill Singer (4-6) | Fifth | 5 out |
| Wednesday, May 28 |
| » Defeated Angels (22-24), 9-2 | Anaheim Stadium (3-0) | 18-23 | Won 3 |
| » W: Eric Raich (1-0) L: Nolan Ryan (8-3) S: Dave LaRoche (1) | Fifth | 5 out |
| Friday, May 30 |
| » Lost to Athletics (28-17), 6-2 | Oakland-Alameda County Stadium (0-1) | 18-24 | |
| » Manager: Frank Robinson |
| » W: Dick Bosman (2-2) L: Jim Kern (1-2) | Fifth | 5 out |
| Former Indian Bert Cole dies in San Mateo, CA at the age of 79. |
| Saturday, May 31 |
| » Defeated Athletics (28-18), 4-1 | Oakland-Alameda County Stadium (1-1) | 19-24 | |
| » W: Dennis Eckersley (3-0) L: Ken Holtzman (3-6) | Fifth | 5 out |
| Sunday, June 1 |
| » Lost to Athletics (29-18), 6-3 | Oakland-Alameda County Stadium (1-2) | 19-25 | |
| » W: Sonny Siebert (5-2) L: Gaylord Perry (6-7) S: Rollie Fingers (5) | Fifth | 6 out |
| Tuesday, June 3 |
| » Lost to Royals (30-20), 5-2 | Cleveland Stadium (8-13) | 19-26 | Lost 2 |
| » W: Dennis Leonard (2-1) L: Fritz Peterson (4-5) | Fifth | 6½ out |
| Wednesday, June 4 |
| » Defeated Royals (30-21), 4-0 | Cleveland Stadium (9-13) | 20-26 | |
| » W: Blue Moon Odom (1-2) L: Steve Busby (7-4) | Fifth | 6½ out |
| Thursday, June 5 |
| » Defeated Royals (30-22), 8-7 | Cleveland Stadium (10-13) | 21-26 | Won 2 |
| » W: Dave LaRoche (1-0) L: Marty Pattin (3-1) | Fifth | 6 out |
| Friday, June 6 |
| » Defeated Rangers (24-26), 7-5 | Cleveland Stadium (11-13) | 22-26 | Won 3 |
| » W: Dave LaRoche (2-0) L: Fergie Jenkins (5-6) | Fifth | 6 out |
| Saturday, June 7 |
| » Lost to Rangers (25-26), 5-4 | Cleveland Stadium (11-14) | 22-27 | |
| » W: Stan Thomas (2-0) L: Gaylord Perry (6-8) | Fifth | 7 out |
| Sunday, June 8 |
| » Defeated Rangers (25-27), 3-2 | Cleveland Stadium (12-14) | 23-27 | |
| » W: Eric Raich (2-0) L: Jim Bibby (2-5) S: Dave LaRoche (2) | Fifth | 6½ out |
| » Lost to Rangers (26-27), 7-6 | Cleveland Stadium (12-15) | 23-28 | |
| » W: Stan Thomas (3-0) L: Tom Buskey (2-2) | Fifth | 6½ out |
| Monday, June 9 |
| » Lost to Twins (25-25), 11-10 | Cleveland Stadium (12-16) | 23-29 | Lost 2 |
| » W: Vic Albury (4-2) L: Tom Buskey (2-3) | Fifth | 6½ out |
| Tuesday, June 10 |
| » Lost to Twins (26-25), 5-3 | Cleveland Stadium (12-17) | 23-30 | Lost 3 |
| » W: Tom Burgmeier (3-2) L: Dave LaRoche (2-1) | Fifth | 6½ out |
| Wednesday, June 11 |
| » Lost to Royals (33-25), 7-1 | Royals Stadium (0-1) | 23-31 | Lost 4 |
| » W: Dennis Leonard (3-2) L: Gaylord Perry (6-9) | Sixth | 7½ out |
| Thursday, June 12 |
| » Lost to Royals (34-25), 2-1 | Royals Stadium (0-2) | 23-32 | Lost 5 |
| » W: Steve Busby (8-5) L: Eric Raich (2-1) | Sixth | 7½ out |
| Friday, June 13 |
| » Lost to Rangers (29-29), 2-1 | Arlington Stadium (0-1) | 23-33 | Lost 6 |
| » W: Jim Umbarger (2-1) L: Fritz Peterson (4-6) S: Mike Kekich (1) | Sixth | 8 out |
| Saturday, June 14 |
| » Lost to Rangers (30-29), 2-1 | Arlington Stadium (0-2) | 23-34 | Lost 7 |
| » W: Fergie Jenkins (7-6) L: Roric Harrison (3-5) | Sixth | 9 out |
| Sunday, June 15 |
| » Defeated Rangers (30-30), 5-1 | Arlington Stadium (1-2) | 24-34 | |
| » W: Dennis Eckersley (4-0) L: Gaylord Perry (6-10) | Sixth | 9 out |
| » Major-league debuts: Mike Bacsik (Rangers) |
| Monday, June 16 |
| » Lost to Orioles (26-32), 8-3 | Cleveland Stadium (12-18) | 24-35 | |
| » W: Jim Palmer (11-3) L: Jim Bibby (2-7) S: Grant Jackson (1) | Sixth | 10 out |
| Tuesday, June 17 |
| » Lost to Orioles (27-32), 5-3 | Cleveland Stadium (12-19) | 24-36 | Lost 2 |
| » W: Mike Cuellar (4-5) L: Eric Raich (2-2) S: Doyle Alexander (1) | Sixth | 11 out |
| Wednesday, June 18 |
| » Lost to Orioles (28-32), 13-6 | Cleveland Stadium (12-20) | 24-37 | Lost 3 |
| » W: Ross Grimsley (3-8) L: Fritz Peterson (4-7) | Sixth | 12 out |
| Friday, June 20 |
| » Lost to Brewers (32-31), 6-0 | Cleveland Stadium (12-21) | 24-38 | Lost 4 |
| » W: Jim Slaton (5-8) L: Roric Harrison (3-6) | Sixth | 13 out |
| Saturday, June 21 |
| » Lost to Brewers (33-31), 11-9 | Cleveland Stadium (12-22) | 24-39 | Lost 5 |
| » W: Pete Broberg (7-7) L: Dennis Eckersley (4-1) S: Bill Travers (1) | Sixth | 13 out |
| Sunday, June 22 |
| » Defeated Brewers (33-32), 3-2 | Cleveland Stadium (13-22) | 25-39 | |
| » W: Tom Buskey (3-3) L: Ed Sprague (1-4) | Sixth | 12½ out |
| Monday, June 23 |
| » Defeated Red Sox (37-27), 11-3 | Fenway Park (2-1) | 26-39 | Won 2 |
| » W: Eric Raich (3-2) L: Jim Burton (0-2) | Sixth | 11½ out |
| Tuesday, June 24 |
| » Defeated Red Sox (37-28), 8-6 | Fenway Park (3-1) | 27-39 | Won 3 |
| » W: Tom Buskey (4-3) L: Dick Drago (1-1) | Fifth | 11 out |
| Wednesday, June 25 |
| » Defeated Red Sox (37-29), 8-5 | Fenway Park (4-1) | 28-39 | Won 4 |
| » W: Roric Harrison (4-6) L: Dick Pole (1-4) S: Tom Buskey (5) | Fifth | 11 out |
| Future Indian Kane Davis is born in Ripley, WV. |
| Thursday, June 26 |
| » Defeated Brewers (37-33), 9-2 | County Stadium (2-2) | 29-39 | Won 5 |
| » W: Dennis Eckersley (5-1) L: Jim Colborn (2-6) | Fifth | 10 out |
| Friday, June 27 |
| » Defeated Brewers (37-34), 6-1 | County Stadium (3-2) | 30-39 | Won 6 |
| » W: Jim Bibby (3-7) L: Ed Sprague (1-5) | Fifth | 9½ out |
| Saturday, June 28 |
| » Lost to Brewers (38-34), 10-6 | County Stadium (3-3) | 30-40 | |
| » W: Rick Austin (1-0) L: Jackie Brown (5-6) | Fifth | 10 out |
| Sunday, June 29 |
| » Lost to Brewers (39-34), 4-3 | County Stadium (3-4) | 30-41 | Lost 2 |
| » W: Eduardo Rodriguez (6-0) L: Don Hood (1-4) | Fifth | 10½ out |
| Monday, June 30 |
| » Defeated Tigers (27-44), 4-1 | Cleveland Stadium (14-22) | 31-41 | |
| » W: Roric Harrison (5-6) L: Vern Ruhle (6-5) | Fifth | 9½ out |
| » Defeated Tigers (27-45), 3-2 | Cleveland Stadium (15-22) | 32-41 | Won 2 |
| » W: Eric Raich (4-2) L: Lerrin LaGrow (4-8) | Fifth | 9½ out |
| Tuesday, July 1 |
| » Lost to Tigers (28-45), 6-2 | Cleveland Stadium (15-23) | 32-42 | |
| » W: Mickey Lolich (9-5) L: Jim Bibby (3-8) | Fourth | 9½ out |
| Wednesday, July 2 |
| » Defeated Yankees (41-35), 3-2 | Cleveland Stadium (16-23) | 33-42 | |
| » W: Dave LaRoche (3-1) L: Dick Tidrow (5-1) | Fifth | 9 out |
| Thursday, July 3 |
| » Defeated Yankees (41-36), 3-2 | Cleveland Stadium (17-23) | 34-42 | Won 2 |
| » W: Don Hood (2-4) L: Doc Medich (6-10) S: Dave LaRoche (3) | Fifth | 8 out |
| Friday, July 4 |
| » Defeated Red Sox (42-35), 3-2 | Cleveland Stadium (18-23) | 35-42 | Won 3 |
| » W: Eric Raich (5-2) L: Luis Tiant (11-8) S: Dave LaRoche (4) | Fifth | 7 out |
| Saturday, July 5 |
| » Defeated Red Sox (42-36), 12-2 | Cleveland Stadium (19-23) | 36-42 | Won 4 |
| » W: Roric Harrison (6-6) L: Steve Barr (0-1) | Fifth | 6 out |
| Sunday, July 6 |
| » Lost to Red Sox (43-36), 5-3 | Cleveland Stadium (19-24) | 36-43 | |
| » W: Bill Lee (10-6) L: Jim Bibby (3-9) S: Dick Drago (7) | Fifth | 6 out |
| » Defeated Red Sox (43-37), 11-10 | Cleveland Stadium (20-24) | 37-43 | |
| » W: Fred Beene (1-0) L: Reggie Cleveland (4-6) S: Dave LaRoche (5) | Fifth | 6 out |
| Monday, July 7 |
| » Lost to Athletics (51-31), 7-3 | Oakland-Alameda County Stadium (1-3) | 37-44 | |
| » W: Jim Perry (3-7) L: Dennis Eckersley (5-2) | Fifth | 7 out |
| Tuesday, July 8 |
| » Lost to Athletics (52-31), 15-5 | Oakland-Alameda County Stadium (1-4) | 37-45 | Lost 2 |
| » W: Ken Holtzman (10-7) L: Don Hood (2-5) | Fifth | 8 out |
| Wednesday, July 9 |
| » Lost to Athletics (53-31), 3-1 | Oakland-Alameda County Stadium (1-5) | 37-46 | Lost 3 |
| » W: Dick Bosman (6-3) L: Eric Raich (5-3) S: Rollie Fingers (11) | Fifth | 9 out |
| Friday, July 11 |
| » Defeated Angels (40-49), 5-3 | Anaheim Stadium (4-0) | 38-46 | |
| » W: Roric Harrison (7-6) L: Dick Lange (3-2) S: Dave LaRoche (6) | Fourth | 9½ out |
| Saturday, July 12 |
| » Defeated Angels (40-50), 9-1 | Anaheim Stadium (5-0) | 39-46 | Won 2 |
| » W: Dennis Eckersley (6-2) L: Nolan Ryan (10-9) | Fifth | 9½ out |
| Sunday, July 13 |
| » Defeated Angels (40-51), 8-7 | Anaheim Stadium (6-0) | 40-46 | Won 3 |
| » W: Jim Bibby (4-9) L: Don Kirkwood (2-4) S: Dave LaRoche (7) | Fifth | 9½ out |
| Thursday, July 17 |
| » Lost to Athletics (56-32), 6-3 | Cleveland Stadium (20-25) | 40-47 | |
| » W: Ken Holtzman (12-7) L: Eric Raich (5-4) S: Paul Lindblad (5) | Fifth | 10½ out |
| Friday, July 18 |
| » Lost to Athletics (57-32), 7-6 | Cleveland Stadium (20-26) | 40-48 | Lost 2 |
| » W: Glenn Abbott (4-2) L: Jim Bibby (4-10) S: Rollie Fingers (13) | Fifth | 11½ out |
| Saturday, July 19 |
| » Lost to Angels (42-52), 8-0 | Cleveland Stadium (20-27) | 40-49 | Lost 3 |
| » W: Frank Tanana (8-5) L: Dennis Eckersley (6-3) | Sixth | 13 out |
| » Lost to Angels (43-52), 3-2 | Cleveland Stadium (20-28) | 40-50 | Lost 4 |
| » W: Don Kirkwood (3-4) L: Dave LaRoche (3-2) S: Chuck Hockenbery (1) | Sixth | 13 out |
| Sunday, July 20 |
| » Defeated Angels (43-53), 10-4 | Cleveland Stadium (21-28) | 41-50 | |
| » W: Don Hood (3-5) L: Dick Lange (3-3) | Sixth | 12½ out |
| Monday, July 21 |
| » Defeated Angels (43-54), 2-1 | Cleveland Stadium (22-28) | 42-50 | Won 2 |
| » W: Dave LaRoche (4-2) L: Ed Figueroa (8-6) | Fifth | 11½ out |
| Tuesday, July 22 |
| » Lost to Rangers (46-51), 4-0 | Arlington Stadium (1-3) | 42-51 | |
| » W: Gaylord Perry (9-14) L: Eric Raich (5-5) | Fifth | 12½ out |
| Wednesday, July 23 |
| » Lost to Rangers (47-51), 9-8 | Arlington Stadium (1-4) | 42-52 | Lost 2 |
| » W: Steve Foucault (3-2) L: Jackie Brown (5-7) | Fifth | 13½ out |
| Friday, July 25 |
| » Lost to Tigers (44-53), 4-3 | Tiger Stadium (1-2) | 42-53 | Lost 3 |
| » W: Ray Bare (6-5) L: Don Hood (3-6) S: Bob Reynolds (2) | Sixth | 14 out |
| Saturday, July 26 |
| » Defeated Tigers (44-54), 6-0 | Tiger Stadium (2-2) | 43-53 | |
| » W: Dennis Eckersley (7-3) L: Mickey Lolich (10-9) | Sixth | 14 out |
| Sunday, July 27 |
| » Lost to Tigers (45-54), 8-7 | Tiger Stadium (2-3) | 43-54 | |
| » W: Fernando Arroyo (1-0) L: Dave LaRoche (4-3) S: Bob Reynolds (3) | Sixth | 15 out |
| » Defeated Tigers (45-55), 7-2 | Tiger Stadium (3-3) | 44-54 | |
| » W: Fritz Peterson (5-7) L: Lerrin LaGrow (7-10) | Sixth | 15 out |
| Monday, July 28 |
| » Defeated Orioles (51-48), 7-5 | Memorial Stadium (2-2) | 45-54 | Won 2 |
| » W: Rick Waits (1-0) L: Doyle Alexander (3-7) S: Fred Beene (1) | Fifth | 15 out |
| Future Indian Chad Paronto is born in Haverhill, NH. |
| Tuesday, July 29 |
| » Lost to Orioles (52-48), 7-1 | Memorial Stadium (2-3) | 45-55 | |
| » W: Mike Torrez (12-6) L: Don Hood (3-7) | Sixth | 15 out |
| Wednesday, July 30 |
| » Defeated Orioles (52-49), 3-1 | Memorial Stadium (3-3) | 46-55 | |
| » W: Dennis Eckersley (8-3) L: Mike Cuellar (10-7) | Fifth | 14 out |
| Friday, August 1 |
| » Lost to Yankees (53-51), 5-4 | Shea Stadium (1-2) | 46-56 | |
| » W: Catfish Hunter (14-10) L: Eric Raich (5-6) S: Dick Tidrow (5) | Fifth | 16 out |
| Saturday, August 2 |
| » Lost to Yankees (54-51), 5-3 | Shea Stadium (1-3) | 46-57 | Lost 2 |
| » W: Sparky Lyle (3-5) L: Jim Bibby (4-11) | Fifth | 17 out |
| Sunday, August 3 |
| » Lost to Yankees (55-51), 12-1 | Shea Stadium (1-4) | 46-58 | Lost 3 |
| » W: Doc Medich (9-12) L: Roric Harrison (7-7) | Fifth | 17½ out |
| » Defeated Yankees (55-52), 3-2 | Shea Stadium (2-4) | 47-58 | |
| » W: Don Hood (4-7) L: Dick Tidrow (6-3) S: Dave LaRoche (8) | Fifth | 17½ out |
| Monday, August 4 |
| » Defeated Tigers (46-63), 6-4 | Cleveland Stadium (23-28) | 48-58 | Won 2 |
| » W: Dennis Eckersley (9-3) L: Mickey Lolich (10-11) S: Jackie Brown (1) | Fifth | 16½ out |
| Tuesday, August 5 |
| » Defeated Tigers (46-64), 8-4 | Cleveland Stadium (24-28) | 49-58 | Won 3 |
| » W: Eric Raich (6-6) L: Ray Bare (6-6) S: Rick Waits (1) | Fifth | 15½ out |
| Wednesday, August 6 |
| » Defeated Yankees (57-53), 5-3 | Cleveland Stadium (25-28) | 50-58 | Won 4 |
| » W: Fritz Peterson (6-7) L: Pat Dobson (9-12) S: Dave LaRoche (9) | Fifth | 15½ out |
| Thursday, August 7 |
| » Lost to Yankees (58-53), 6-3 | Cleveland Stadium (25-29) | 50-59 | |
| » W: Doc Medich (10-12) L: Don Hood (4-8) S: Sparky Lyle (6) | Fifth | 16½ out |
| Friday, August 8 |
| » Defeated Royals (62-50), 4-3 | Cleveland Stadium (26-29) | 51-59 | |
| » W: Roric Harrison (8-7) L: Marty Pattin (8-7) S: Dave LaRoche (10) | Fifth | 15½ out |
| Saturday, August 9 |
| » Lost to Royals (63-50), 6-4 | Cleveland Stadium (26-30) | 51-60 | |
| » W: Lindy McDaniel (4-1) L: Jim Bibby (4-12) S: Doug Bird (9) | Fifth | 16½ out |
| Sunday, August 10 |
| » Lost to Royals (64-50), 5-1 | Cleveland Stadium (26-31) | 51-61 | Lost 2 |
| » W: Al Fitzmorris (12-9) L: Eric Raich (6-7) S: Nelson Briles (1) | Fifth | 17½ out |
| Tuesday, August 12 |
| » Defeated White Sox (56-60), 6-3 | Comiskey Park I (2-2) | 52-61 | |
| » W: Fritz Peterson (7-7) L: Wilbur Wood (12-15) S: Dave LaRoche (11) | Fifth | 17 out |
| Wednesday, August 13 |
| » Lost to White Sox (57-60), 4-3 | Comiskey Park I (2-3) | 52-62 | |
| » W: Rich Gossage (7-6) L: Jim Bibby (4-13) | Fifth | 17 out |
| Thursday, August 14 |
| » Lost to White Sox (58-60), 6-4 | Comiskey Park I (2-4) | 52-63 | Lost 2 |
| » W: Jim Kaat (17-9) L: Roric Harrison (8-8) S: Dave Hamilton (4) | Fifth | 17 out |
| Friday, August 15 |
| » Lost to Twins (55-66), 8-4 | Metropolitan Stadium (1-3) | 52-64 | Lost 3 |
| » W: Bert Blyleven (12-6) L: Dennis Eckersley (9-4) | Fifth | 18 out |
| Saturday, August 16 |
| » Lost to Twins (56-66), 9-1 | Metropolitan Stadium (1-4) | 52-65 | Lost 4 |
| » W: Jim Hughes (11-10) L: Eric Raich (6-8) | Fifth | 19 out |
| Sunday, August 17 |
| » Defeated Twins (56-67), 14-5 | Metropolitan Stadium (2-4) | 53-65 | |
| » W: Fritz Peterson (8-7) L: Bill Butler (1-4) | Fifth | 18½ out |
| » Major-league debuts: Rick Cerone (Indians) |
| Monday, August 18 |
| » Defeated Rangers (60-64), 4-3 | Cleveland Stadium (27-31) | 54-65 | Won 2 |
| » W: Rick Waits (2-0) L: Steve Hargan (8-7) | Fourth | 17½ out |
| » Defeated Rangers (60-65), 4-2 | Cleveland Stadium (28-31) | 55-65 | Won 3 |
| » W: Roric Harrison (9-8) L: Fergie Jenkins (14-13) S: Dave LaRoche (12) | Fourth | 17½ out |
| Tuesday, August 19 |
| » Lost to Rangers (61-65), 2-1 | Cleveland Stadium (28-32) | 55-66 | |
| » W: Jim Umbarger (5-5) L: Dennis Eckersley (9-5) S: Steve Foucault (7) | Fourth | 18½ out |
| Wednesday, August 20 |
| Former Indian Jake Miller dies in Venice, FL at the age of 78. |
| Thursday, August 21 |
| » Defeated Royals (68-55), 7-3 | Royals Stadium (1-2) | 56-66 | |
| » W: Jackie Brown (6-7) L: Mark Littell (0-1) | Fourth | 17½ out |
| Friday, August 22 |
| » Defeated Royals (68-56), 9-5 | Royals Stadium (2-2) | 57-66 | Won 2 |
| » W: Fritz Peterson (9-7) L: Paul Splittorff (6-7) S: Jim Bibby (1) | Fourth | 17½ out |
| Saturday, August 23 |
| » Defeated Royals (68-57), 7-1 | Royals Stadium (3-2) | 58-66 | Won 3 |
| » W: Rick Waits (3-0) L: Nelson Briles (6-6) | Fourth | 16½ out |
| Sunday, August 24 |
| » Lost to Royals (69-57), 5-2 | Royals Stadium (3-3) | 58-67 | |
| » W: Al Fitzmorris (13-10) L: Roric Harrison (9-9) S: Doug Bird (10) | Fourth | 17½ out |
| Monday, August 25 |
| » Defeated White Sox (63-66), 5-1 | Cleveland Stadium (29-32) | 59-67 | |
| » W: Dennis Eckersley (10-5) L: Jim Kaat (18-10) | Fourth | 17 out |
| Wednesday, August 27 |
| » Lost to White Sox (64-66), 2-0 | Cleveland Stadium (29-33) | 59-68 | |
| » W: Claude Osteen (7-12) L: Jim Bibby (4-14) S: Rich Gossage (21) | Fourth | 17 out |
| » Defeated White Sox (64-67), 5-0 | Cleveland Stadium (30-33) | 60-68 | |
| » W: Fritz Peterson (10-7) L: Jesse Jefferson (4-8) | Fourth | 17 out |
| Friday, August 29 |
| » Defeated Twins (63-70), 9-6 | Cleveland Stadium (31-33) | 61-68 | Won 2 |
| » W: Don Hood (5-8) L: Jim Hughes (12-12) S: Bob Reynolds (4) | Fourth | 17 out |
| Tuesday, September 2 |
| » Lost to Orioles (74-60), 3-2 | Memorial Stadium (3-4) | 61-69 | |
| » W: Mike Cuellar (14-10) L: Bob Reynolds (0-4) | Fourth | 16 out |
| » Defeated Orioles (74-61), 2-1 | Memorial Stadium (4-4) | 62-69 | |
| » W: Jim Bibby (5-14) L: Doyle Alexander (6-8) S: Dave LaRoche (13) | Fourth | 16 out |
| Wednesday, September 3 |
| » Defeated Brewers (60-78), 11-3 | County Stadium (4-4) | 63-69 | Won 2 |
| » W: Fritz Peterson (11-7) L: Jim Slaton (11-17) S: Bob Reynolds (5) | Fourth | 16 out |
| Thursday, September 4 |
| » Defeated Brewers (60-79), 10-5 | County Stadium (5-4) | 64-69 | Won 3 |
| » W: Roric Harrison (10-9) L: Lafayette Currence (0-2) | Fourth | 16 out |
| Friday, September 5 |
| » Lost to Tigers (54-84), 11-2 | Cleveland Stadium (31-34) | 64-70 | |
| » W: Vern Ruhle (11-10) L: Rick Waits (3-1) | Fourth | 16 out |
| » Major-league debuts: Larry Andersen (Indians) |
| Saturday, September 6 |
| » Defeated Tigers (54-85), 4-2 | Cleveland Stadium (32-34) | 65-70 | |
| » W: Dennis Eckersley (11-5) L: Dave Lemanczyk (2-5) S: Dave LaRoche (14) | Fourth | 16 out |
| Sunday, September 7 |
| » Defeated Tigers (54-86), 7-2 | Cleveland Stadium (33-34) | 66-70 | Won 2 |
| » W: Jim Bibby (6-14) L: Joe Coleman (9-16) S: Tom Buskey (6) | Fourth | 15 out |
| » Defeated Tigers (54-87), 9-0 | Cleveland Stadium (34-34) | 67-70 | Won 3 |
| » W: Fritz Peterson (12-7) L: Lerrin LaGrow (7-14) | Fourth | 15 out |
| Monday, September 8 |
| » Defeated Red Sox (84-58), 4-1 | Cleveland Stadium (35-34) | 68-70 | Won 4 |
| » W: Don Hood (6-8) L: Rick Wise (18-9) | Fourth | 14 out |
| Tuesday, September 9 |
| » Defeated Red Sox (84-59), 3-2 | Cleveland Stadium (36-34) | 69-70 | Won 5 |
| » W: Rick Waits (4-1) L: Bill Lee (17-9) | Fourth | 13 out |
| Wednesday, September 10 |
| » Defeated Orioles (79-65), 7-1 | Cleveland Stadium (37-34) | 70-70 | Won 6 |
| » W: Dennis Eckersley (12-5) L: Mike Cuellar (14-11) S: Dave LaRoche (15) | Fourth | 13 out |
| » Lost to Orioles (80-65), 6-5 | Cleveland Stadium (37-35) | 70-71 | |
| » W: Dyar Miller (5-3) L: Bob Reynolds (0-5) S: Wayne Garland (4) | Fourth | 13 out |
| Thursday, September 11 |
| » Lost to Orioles (81-65), 10-2 | Cleveland Stadium (37-36) | 70-72 | Lost 2 |
| » W: Jim Palmer (21-10) L: Roric Harrison (10-10) | Fourth | 14 out |
| Friday, September 12 |
| » Major-league debuts: Roy Staiger (Mets) |
| Saturday, September 13 |
| » Defeated Yankees (75-72), 7-1 | Shea Stadium (3-4) | 71-72 | |
| » W: Fritz Peterson (13-7) L: Rudy May (13-11) | Fourth | 14 out |
| » Lost to Yankees (76-72), 4-3 | Shea Stadium (3-5) | 71-73 | |
| » W: Doc Medich (14-16) L: Jim Bibby (6-15) S: Tippy Martinez (8) | Fourth | 14 out |
| Sunday, September 14 |
| » Lost to Yankees (77-72), 6-2 | Shea Stadium (3-6) | 71-74 | Lost 2 |
| » W: Catfish Hunter (22-13) L: Rick Waits (4-2) | Fourth | 15 out |
| Tuesday, September 16 |
| » Defeated Tigers (55-95), 9-2 | Tiger Stadium (4-3) | 72-74 | |
| » W: Dennis Eckersley (13-5) L: Fernando Arroyo (2-1) | Fourth | 15½ out |
| Wednesday, September 17 |
| » Lost to Tigers (56-95), 4-0 | Tiger Stadium (4-4) | 72-75 | |
| » W: Joe Coleman (10-17) L: Roric Harrison (10-11) | Fourth< |
