| Wednesday, January 1 |
| Future Cardinal Fernando Tatis is born in San Pedro de Macoris, D.R. |
| Thursday, January 9 |
| Future Cardinal Kiko Calero is born in Santurce, P.R. Former Cardinal Walt Cruise dies in Sylacauga, AL at the age of 85. |
| Thursday, January 23 |
| Former Cardinal Heinie Mueller dies in DeSoto, MO at the age of 76. |
| Friday, March 21 |
| Former Cardinal Joe Medwick dies in St.Petersburg, FL at the age of 64. |
| Tuesday, March 25 |
| Future Cardinal Miguel Mejia is born in San Pedro de Macoris, D.R. |
| Monday, April 7 |
| » Lost to Expos (1-0), 8-4 | Busch Stadium II (0-1) | 0-1 | |
| » W: Dave McNally (1-0) L: Bob Gibson (0-1) S: Dale Murray (1) | Third | 1 out |
| Wednesday, April 9 |
| » Defeated Expos (1-1), 4-0 | Busch Stadium II (1-1) | 1-1 | |
| » W: Bob Forsch (1-0) L: Steve Rogers (0-1) | Third | ½ out |
| Thursday, April 10 |
| » Defeated Expos (1-2), 7-2 | Busch Stadium II (2-1) | 2-1 | Won 2 |
| » W: John Denny (1-0) L: Dale Murray (0-1) S: Al Hrabosky (1) | Second | 1 out |
| Friday, April 11 |
| » Defeated Phillies (1-2), 6-3 | Veteran's Stadium (1-0) | 3-1 | Won 3 |
| » W: Lynn McGlothen (1-0) L: Wayne Twitchell (0-1) S: Al Hrabosky (2) | Second | 1 out |
| Saturday, April 12 |
| » Defeated Phillies (1-3), 7-5 | Veteran's Stadium (2-0) | 4-1 | Won 4 |
| » W: Mike Garman (1-0) L: Gene Garber (0-1) | Second | 1½ out |
| Sunday, April 13 |
| » Lost to Phillies (2-3), 2-0 | Veteran's Stadium (2-1) | 4-2 | |
| » W: Tom Underwood (1-0) L: Bob Forsch (1-1) | Third | 1½ out |
| Wednesday, April 16 |
| » Defeated Mets (1-5), 3-2 | Busch Stadium II (3-1) | 5-2 | |
| » W: John Denny (2-0) L: Jon Matlack (0-1) S: Mike Garman (1) | Second | ½ out |
| Thursday, April 17 |
| » Lost to Mets (2-5), 14-7 | Busch Stadium II (3-2) | 5-3 | |
| » W: Rick Baldwin (1-1) L: Elias Sosa (0-1) | Second | 1½ out |
| Friday, April 18 |
| » Defeated Pirates (3-4), 5-4 | Busch Stadium II (4-2) | 6-3 | |
| » W: Ray Sadecki (1-0) L: Sam McDowell (0-1) | Second | 1 out |
| Saturday, April 19 |
| » Lost to Pirates (4-4), 7-1 | Busch Stadium II (4-3) | 6-4 | |
| » W: Jim Rooker (1-0) L: Bob Forsch (1-2) | Second | 2 out |
| Sunday, April 20 |
| » Lost to Pirates (5-4), 5-0 | Busch Stadium II (4-4) | 6-5 | Lost 2 |
| » W: Ken Brett (1-0) L: John Denny (2-1) S: Dave Giusti (1) | Third | 1½ out |
| Tuesday, April 22 |
| » Lost to Mets (5-6), 9-5 | Shea Stadium (0-1) | 6-6 | Lost 3 |
| » W: Jerry Koosman (1-0) L: Lynn McGlothen (1-1) | Fourth | 1½ out |
| Wednesday, April 23 |
| » Lost to Mets (6-6), 7-1 | Shea Stadium (0-2) | 6-7 | Lost 4 |
| » W: Tom Seaver (2-2) L: Bob Gibson (0-2) | Third | 2½ out |
| Friday, April 25 |
| » Lost to Cubs (10-4), 4-3 | Wrigley Field (0-1) | 6-8 | Lost 5 |
| » W: Darold Knowles (1-0) L: Al Hrabosky (0-1) | Fourth | 4 out |
| Saturday, April 26 |
| » Lost to Cubs (11-4), 8-6 | Wrigley Field (0-2) | 6-9 | Lost 6 |
| » W: Ken Frailing (2-1) L: Jack Curtis (0-1) S: Oscar Zamora (2) | Third | 5 out |
| Tuesday, April 29 |
| » Defeated Pirates (8-7), 3-0 | Three Rivers Stadium (1-0) | 7-9 | |
| » W: Lynn McGlothen (2-1) L: Ken Brett (1-1) | Fourth | 4 out |
| Wednesday, April 30 |
| » Lost to Pirates (9-7), 5-0 | Three Rivers Stadium (1-1) | 7-10 | |
| » W: Jerry Reuss (1-2) L: Bob Gibson (0-3) | Fourth | 5 out |
| Friday, May 2 |
| » Defeated Cubs (13-6), 5-1 | Busch Stadium II (5-4) | 8-10 | |
| » W: Bob Forsch (2-2) L: Rick Reuschel (1-2) | Fifth | 4½ out |
| Saturday, May 3 |
| » Lost to Cubs (14-6), 7-3 | Busch Stadium II (5-5) | 8-11 | |
| » W: Bill Bonham (2-1) L: Mike Garman (1-1) S: Darold Knowles (4) | Fifth | 5½ out |
| Future Cardinal Gabe Molina is born in Denver, CO. |
| Sunday, May 4 |
| » Lost to Cubs (15-6), 8-6 | Busch Stadium II (5-6) | 8-12 | Lost 2 |
| » W: Oscar Zamora (2-0) L: Lynn McGlothen (2-2) S: Darold Knowles (5) | Fifth | 6½ out |
| Monday, May 5 |
| » Defeated Phillies (11-11), 11-3 | Busch Stadium II (6-6) | 9-12 | |
| » W: Bob Gibson (1-3) L: Steve Carlton (1-4) | Fifth | 5½ out |
| Wednesday, May 7 |
| » Lost to Phillies (12-11), 4-1 | Busch Stadium II (6-7) | 9-13 | |
| » W: Wayne Twitchell (3-3) L: Bob Forsch (2-3) S: Tug McGraw (2) | Fifth | 6 out |
| Thursday, May 8 |
| » Lost to Phillies (13-11), 6-2 | Busch Stadium II (6-8) | 9-14 | Lost 2 |
| » W: Jim Lonborg (3-1) L: John Denny (2-2) | Fifth | 6½ out |
| Friday, May 9 |
| » Defeated Giants (14-14), 6-4 | Busch Stadium II (7-8) | 10-14 | |
| » W: Lynn McGlothen (3-2) L: John D'Acquisto (1-4) S: Al Hrabosky (3) | Fifth | 6½ out |
| Saturday, May 10 |
| » Defeated Giants (14-15), 9-2 | Busch Stadium II (8-8) | 11-14 | Won 2 |
| » W: Jack Curtis (1-1) L: Charlie Williams (0-2) | Fourth | 6½ out |
| Sunday, May 11 |
| » Defeated Giants (14-16), 4-3 | Busch Stadium II (9-8) | 12-14 | Won 3 |
| » W: Bob Forsch (3-3) L: Pete Falcone (3-2) S: Al Hrabosky (4) | Fourth | 5½ out |
| Monday, May 12 |
| » Lost to Dodgers (22-11), 6-4 | Busch Stadium II (9-9) | 12-15 | |
| » W: Jim Brewer (2-1) L: Mike Garman (1-2) | Fifth | 6 out |
| Tuesday, May 13 |
| » Lost to Dodgers (23-11), 5-0 | Busch Stadium II (9-10) | 12-16 | Lost 2 |
| » W: Burt Hooton (1-3) L: Lynn McGlothen (3-3) | Fifth | 7 out |
| Wednesday, May 14 |
| » Defeated Dodgers (23-12), 7-4 | Busch Stadium II (10-10) | 13-16 | |
| » W: Jack Curtis (2-1) L: Doug Rau (5-2) S: Al Hrabosky (5) | Fifth | 6 out |
| Friday, May 16 |
| » Lost to Giants (15-18), 4-3 | Candlestick Park (0-1) | 13-17 | |
| » W: Gary Lavelle (3-0) L: Elias Sosa (0-2) | Sixth | 6½ out |
| Saturday, May 17 |
| » Defeated Giants (15-19), 17-2 | Candlestick Park (1-1) | 14-17 | |
| » W: Bob Forsch (4-3) L: Pete Falcone (3-3) | Fifth | 5½ out |
| Sunday, May 18 |
| » Lost to Giants (16-19), 2-0 | Candlestick Park (1-2) | 14-18 | |
| » W: Jim Barr (4-3) L: Lynn McGlothen (3-4) | Fifth | 6½ out |
| Monday, May 19 |
| » Lost to Padres (18-19), 1-0 | San Diego/Jack Murphy Stadium (0-1) | 14-19 | Lost 2 |
| » W: Randy Jones (5-2) L: Jack Curtis (2-2) | Sixth | 6½ out |
| Tuesday, May 20 |
| » Lost to Padres (19-19), 5-2 | San Diego/Jack Murphy Stadium (0-2) | 14-20 | Lost 3 |
| » W: Alan Foster (2-1) L: Elias Sosa (0-3) | Sixth | 7½ out |
| Wednesday, May 21 |
| » Lost to Padres (20-19), 1-0 | San Diego/Jack Murphy Stadium (0-3) | 14-21 | Lost 4 |
| » W: Joe McIntosh (5-2) L: Bob Gibson (1-4) | Sixth | 7½ out |
| Friday, May 23 |
| » Defeated Dodgers (27-16), 4-3 | Dodger Stadium (1-0) | 15-21 | |
| » W: Al Hrabosky (1-1) L: Charlie Hough (0-4) S: Mike Garman (2) | Fifth | 6 out |
| Saturday, May 24 |
| » Defeated Dodgers (27-17), 6-2 | Dodger Stadium (2-0) | 16-21 | Won 2 |
| » W: Lynn McGlothen (4-4) L: Doug Rau (5-3) S: Al Hrabosky (6) | Fifth | 5 out |
| Sunday, May 25 |
| » Lost to Dodgers (28-17), 7-3 | Dodger Stadium (2-1) | 16-22 | |
| » W: Don Sutton (8-3) L: Jack Curtis (2-3) | Fifth | 5 out |
| Monday, May 26 |
| » Lost to Padres (23-21), 9-6 | Busch Stadium II (10-11) | 16-23 | Lost 2 |
| » W: Bill Greif (1-1) L: Al Hrabosky (1-2) S: Danny Frisella (2) | Fifth | 6 out |
| Tuesday, May 27 |
| » Defeated Padres (23-22), 7-1 | Busch Stadium II (11-11) | 17-23 | |
| » W: Bob Forsch (5-3) L: Dave Freisleben (3-5) | Fifth | 5 out |
| Wednesday, May 28 |
| » Defeated Padres (23-23), 6-5 | Busch Stadium II (12-11) | 18-23 | Won 2 |
| » W: Mike Garman (2-2) L: Bill Greif (1-2) | Fifth | 5 out |
| Friday, May 30 |
| » Defeated Reds (27-21), 5-4 | Busch Stadium II (13-11) | 19-23 | Won 3 |
| » W: Al Hrabosky (2-2) L: Rawly Eastwick (0-1) | Fifth | 4½ out |
| Saturday, May 31 |
| » Lost to Reds (28-21), 6-0 | Busch Stadium II (13-12) | 19-24 | |
| » W: Don Gullett (6-3) L: Bob Gibson (1-5) | Fifth | 5½ out |
| Sunday, June 1 |
| » Lost to Reds (29-21), 5-1 | Busch Stadium II (13-13) | 19-25 | Lost 2 |
| » W: Jack Billingham (5-3) L: Bob Forsch (5-4) | Fifth | 6 out |
| Monday, June 2 |
| » Defeated Braves (24-28), 1-0 | Busch Stadium II (14-13) | 20-25 | |
| » W: Lynn McGlothen (5-4) L: Carl Morton (5-6) | Fifth | 5½ out |
| Tuesday, June 3 |
| » Defeated Braves (24-29), 4-2 | Busch Stadium II (15-13) | 21-25 | Won 2 |
| » W: Ron Reed (5-5) L: Buzz Capra (4-7) S: Al Hrabosky (7) | Fifth | 5½ out |
| Wednesday, June 4 |
| » Defeated Braves (24-30), 5-2 | Busch Stadium II (16-13) | 22-25 | Won 3 |
| » W: Jack Curtis (3-3) L: Ray Sadecki (1-1) S: Al Hrabosky (8) | Fifth | 4½ out |
| Friday, June 6 |
| » Defeated Astros (20-37), 6-0 | Astrodome (1-0) | 23-25 | Won 4 |
| » W: Bob Forsch (6-4) L: Larry Dierker (5-6) | Fifth | 4 out |
| Saturday, June 7 |
| » Defeated Astros (20-38), 5-1 | Astrodome (2-0) | 24-25 | Won 5 |
| » W: Lynn McGlothen (6-4) L: Dave Roberts (3-7) | Fifth | 4 out |
| Sunday, June 8 |
| » Defeated Astros (20-39), 5-1 | Astrodome (3-0) | 25-25 | Won 6 |
| » W: Ron Reed (6-5) L: Ken Forsch (2-4) S: Al Hrabosky (9) | Fifth | 2½ out |
| Monday, June 9 |
| » Defeated Braves (26-32), 5-4 | Atlanta-Fulton County Stadium (1-0) | 26-25 | Won 7 |
| » W: Jack Curtis (4-3) L: Blue Moon Odom (1-3) S: Al Hrabosky (10) | Fifth | 2½ out |
| Wednesday, June 11 |
| » Lost to Reds (35-24), 3-1 | Riverfront Stadium (0-1) | 26-26 | |
| » W: Don Gullett (8-3) L: Bob Forsch (6-5) | Fourth | 3 out |
| Thursday, June 12 |
| » Lost to Reds (36-24), 10-1 | Riverfront Stadium (0-2) | 26-27 | Lost 2 |
| » W: Gary Nolan (7-3) L: Lynn McGlothen (6-5) | Fifth | 4 out |
| Friday, June 13 |
| » Defeated Astros (22-42), 6-2 | Busch Stadium II (17-13) | 27-27 | |
| » W: Ron Reed (7-5) L: Paul Siebert (0-1) | Fourth | 4 out |
| Saturday, June 14 |
| » Lost to Astros (23-42), 9-0 | Busch Stadium II (17-14) | 27-28 | |
| » W: Tom Griffin (3-6) L: Jack Curtis (4-4) | Fifth | 5 out |
| Sunday, June 15 |
| » Lost to Astros (24-42), 8-7 | Busch Stadium II (17-15) | 27-29 | Lost 2 |
| » W: Joe Niekro (2-1) L: Mike Garman (2-3) | Fifth | 6 out |
| Monday, June 16 |
| » Lost to Pirates (34-23), 10-4 | Three Rivers Stadium (1-2) | 27-30 | Lost 3 |
| » W: Bruce Kison (7-2) L: Ron Bryant (0-1) | Fifth | 7 out |
| Tuesday, June 17 |
| » Defeated Pirates (34-24), 7-4 | Three Rivers Stadium (2-2) | 28-30 | |
| » W: Lynn McGlothen (7-5) L: Dock Ellis (3-4) S: Mike Garman (3) | Fifth | 6 out |
| Wednesday, June 18 |
| » Lost to Pirates (35-24), 9-3 | Three Rivers Stadium (2-3) | 28-31 | |
| » W: Jim Rooker (5-3) L: Ron Reed (7-6) | Fifth | 7 out |
| » Major-league debuts: Mike Barlow (Cardinals) |
| Thursday, June 19 |
| » Lost to Pirates (36-24), 5-0 | Three Rivers Stadium (2-4) | 28-32 | Lost 2 |
| » W: Jerry Reuss (8-4) L: Jack Curtis (4-5) | Fifth | 8 out |
| Friday, June 20 |
| » Defeated Cubs (32-33), 8-3 | Busch Stadium II (18-15) | 29-32 | |
| » W: Bob Forsch (7-5) L: Geoff Zahn (2-5) | Fifth | 8 out |
| Saturday, June 21 |
| » Lost to Cubs (33-33), 6-1 | Busch Stadium II (18-16) | 29-33 | |
| » W: Rick Reuschel (5-6) L: Bob Gibson (1-6) | Fifth | 9 out |
| Sunday, June 22 |
| » Defeated Cubs (33-34), 7-2 | Busch Stadium II (19-16) | 30-33 | |
| » W: Lynn McGlothen (8-5) L: Steve Stone (5-2) | Fifth | 9 out |
| Monday, June 23 |
| » Defeated Mets (32-31), 1-0 | Shea Stadium (1-2) | 31-33 | Won 2 |
| » W: Ron Reed (8-6) L: Hank Webb (1-3) | Fifth | 7½ out |
| » Defeated Mets (32-32), 4-0 | Shea Stadium (2-2) | 32-33 | Won 3 |
| » W: John Denny (3-2) L: George Stone (1-1) | Fifth | 7½ out |
| Tuesday, June 24 |
| » Lost to Mets (33-32), 5-1 | Shea Stadium (2-3) | 32-34 | |
| » W: Jerry Koosman (6-5) L: Jack Curtis (4-6) | Fifth | 7 out |
| Wednesday, June 25 |
| » Lost to Mets (34-32), 2-1 | Shea Stadium (2-4) | 32-35 | Lost 2 |
| » W: Tom Seaver (11-4) L: Bob Forsch (7-6) S: Rick Baldwin (3) | Fifth | 7 out |
| Thursday, June 26 |
| » Defeated Expos (29-37), 4-3 | Parc Jarry (1-0) | 33-35 | |
| » W: Lynn McGlothen (9-5) L: Woodie Fryman (6-4) S: Mike Garman (4) | Fifth | 7 out |
| Friday, June 27 |
| » Defeated Expos (29-38), 6-4 | Parc Jarry (2-0) | 34-35 | Won 2 |
| » W: Bob Gibson (2-6) L: Steve Rogers (5-5) S: Mike Garman (5) | Fourth | 8 out |
| » Lost to Expos (30-38), 5-4 | Parc Jarry (2-1) | 34-36 | |
| » W: Dan Warthen (4-2) L: Ron Reed (8-7) | Fourth | 8 out |
| Saturday, June 28 |
| » Defeated Expos (30-39), 3-2 | Parc Jarry (3-1) | 35-36 | |
| » W: Al Hrabosky (3-2) L: Don DeMola (2-2) S: Mike Garman (6) | Fourth | 7 out |
| Sunday, June 29 |
| » Lost to Expos (31-39), 7-3 | Parc Jarry (3-2) | 35-37 | |
| » W: Steve Renko (3-6) L: Jack Curtis (4-7) | Fourth | 8½ out |
| Monday, June 30 |
| » Defeated Phillies (42-34), 4-2 | Veteran's Stadium (3-1) | 36-37 | |
| » W: Bob Forsch (8-6) L: Jim Lonborg (6-6) S: Al Hrabosky (11) | Fourth | 8½ out |
| Tuesday, July 1 |
| » Defeated Phillies (42-35), 6-5 | Veteran's Stadium (4-1) | 37-37 | Won 2 |
| » W: Lynn McGlothen (10-5) L: Wayne Twitchell (4-9) S: Al Hrabosky (12) | Fourth | 8½ out |
| Wednesday, July 2 |
| » Lost to Phillies (43-35), 5-3 | Veteran's Stadium (4-2) | 37-38 | |
| » W: Steve Carlton (7-6) L: Ron Reed (8-8) | Fourth | 9 out |
| Thursday, July 3 |
| » Lost to Phillies (44-35), 7-4 | Veteran's Stadium (4-3) | 37-39 | Lost 2 |
| » W: Tom Underwood (9-5) L: Bob Gibson (2-7) | Fourth | 10 out |
| Friday, July 4 |
| » Lost to Expos (32-42), 5-1 | Busch Stadium II (19-17) | 37-40 | Lost 3 |
| » W: Steve Renko (4-6) L: John Denny (3-3) S: Dan Warthen (2) | Fourth | 9½ out |
| Saturday, July 5 |
| » Lost to Expos (33-42), 3-0 | Busch Stadium II (19-18) | 37-41 | Lost 4 |
| » W: Dennis Blair (6-9) L: Bob Forsch (8-7) S: Dan Warthen (3) | Fourth | 10 out |
| » Defeated Expos (33-43), 1-0 | Busch Stadium II (20-18) | 38-41 | |
| » W: Jack Curtis (5-7) L: Woodie Fryman (6-6) S: Al Hrabosky (13) | Fourth | 10 out |
| Sunday, July 6 |
| » Lost to Expos (34-43), 4-3 | Busch Stadium II (20-19) | 38-42 | |
| » W: Don DeMola (3-2) L: Lynn McGlothen (10-6) | Fourth | 11 out |
| Monday, July 7 |
| » Defeated Giants (39-44), 8-6 | Busch Stadium II (21-19) | 39-42 | |
| » W: Ron Reed (9-8) L: Mike Caldwell (5-8) S: Al Hrabosky (14) | Fourth | 11 out |
| Tuesday, July 8 |
| » Lost to Giants (40-44), 6-4 | Busch Stadium II (21-20) | 39-43 | |
| » W: Pete Falcone (7-6) L: Bob Gibson (2-8) S: Gary Lavelle (4) | Fourth | 11 out |
| Wednesday, July 9 |
| » Defeated Giants (40-45), 9-0 | Busch Stadium II (22-20) | 40-43 | |
| » W: John Denny (4-3) L: John Montefusco (6-4) | Fourth | 11 out |
| Friday, July 11 |
| » Lost to Dodgers (49-40), 6-5 | Busch Stadium II (22-21) | 40-44 | |
| » W: Mike Marshall (4-5) L: Mike Garman (2-4) | Fourth | 13 out |
| Saturday, July 12 |
| » Defeated Dodgers (49-41), 2-1 | Busch Stadium II (23-21) | 41-44 | |
| » W: Al Hrabosky (4-2) L: Rick Rhoden (1-1) | Fourth | 13 out |
| Sunday, July 13 |
| » Defeated Dodgers (49-42), 2-1 | Busch Stadium II (24-21) | 42-44 | Won 2 |
| » W: Al Hrabosky (5-2) L: Mike Marshall (4-6) | Fourth | 12 out |
| Thursday, July 17 |
| » Defeated Giants (41-48), 1-0 | Candlestick Park (2-2) | 43-44 | Won 3 |
| » W: Al Hrabosky (6-2) L: Jim Barr (6-8) | Fourth | 12 out |
| Friday, July 18 |
| » Lost to Giants (42-48), 2-1 | Candlestick Park (2-3) | 43-45 | |
| » W: Gary Lavelle (5-3) L: Greg Terlecky (0-1) | Fourth | 12 out |
| Saturday, July 19 |
| » Lost to Giants (43-48), 5-2 | Candlestick Park (2-4) | 43-46 | Lost 2 |
| » W: John Montefusco (8-4) L: Lynn McGlothen (10-7) | Fourth | 13 out |
| Sunday, July 20 |
| » Defeated Padres (43-51), 3-1 | San Diego/Jack Murphy Stadium (1-3) | 44-46 | |
| » W: Al Hrabosky (7-2) L: Bill Greif (2-3) | Fourth | 12 out |
| » Defeated Padres (43-52), 10-2 | San Diego/Jack Murphy Stadium (2-3) | 45-46 | Won 2 |
| » W: Jack Curtis (6-7) L: Rich Folkers (3-8) | Fourth | 12 out |
| Monday, July 21 |
| » Defeated Padres (43-53), 4-0 | San Diego/Jack Murphy Stadium (3-3) | 46-46 | Won 3 |
| » W: Eric Rasmussen (1-0) L: Brent Strom (5-4) | Fourth | 11 out |
| » Major-league debuts: Eric Rasmussen (Cardinals) |
| Tuesday, July 22 |
| » Defeated Dodgers (51-46), 4-3 | Dodger Stadium (3-1) | 47-46 | Won 4 |
| » W: Al Hrabosky (8-2) L: Mike Marshall (6-8) | Fourth | 10 out |
| Wednesday, July 23 |
| » Defeated Dodgers (51-47), 5-4 | Dodger Stadium (4-1) | 48-46 | Won 5 |
| » W: Bob Forsch (9-7) L: Don Sutton (13-9) S: Mike Garman (7) | Fourth | 10 out |
| Thursday, July 24 |
| » Lost to Dodgers (52-47), 8-2 | Dodger Stadium (4-2) | 48-47 | |
| » W: Burt Hooton (7-9) L: Lynn McGlothen (10-8) | Fourth | 10½ out |
| Future Cardinal Bill Ortega is born in Havana, Cuba. |
| Friday, July 25 |
| » Defeated Phillies (55-43), 4-3 | Busch Stadium II (25-21) | 49-47 | |
| » W: Al Hrabosky (9-2) L: Gene Garber (7-6) | Fourth | 11 out |
| » Lost to Phillies (56-43), 5-2 | Busch Stadium II (25-22) | 49-48 | |
| » W: Ron Schueler (4-2) L: Jack Curtis (6-8) S: Tug McGraw (9) | Fourth | 11 out |
| Saturday, July 26 |
| » Lost to Phillies (57-43), 9-4 | Busch Stadium II (25-23) | 49-49 | Lost 2 |
| » W: Steve Carlton (10-7) L: Eric Rasmussen (1-1) | Fourth | 11 out |
| Sunday, July 27 |
| » Defeated Phillies (57-44), 9-6 | Busch Stadium II (26-23) | 50-49 | |
| » W: Bob Gibson (3-8) L: Tom Hilgendorf (2-1) S: Mike Garman (8) | Fourth | 11½ out |
| Monday, July 28 |
| » Lost to Mets (52-46), 11-7 | Busch Stadium II (26-24) | 50-50 | |
| » W: Jon Matlack (12-8) L: Bob Forsch (9-8) S: Bob Apodaca (8) | Fourth | 11½ out |
| Tuesday, July 29 |
| » Defeated Mets (52-47), 5-3 | Busch Stadium II (27-24) | 51-50 | |
| » W: Lynn McGlothen (11-8) L: Tom Seaver (14-7) S: Mike Garman (9) | Fourth | 11 out |
| » Lost to Mets (53-47), 11-6 | Busch Stadium II (27-25) | 51-51 | |
| » W: Tom Hall (4-2) L: Ron Reed (9-9) S: Rick Baldwin (6) | Fourth | 11 out |
| Wednesday, July 30 |
| » Defeated Mets (53-48), 5-2 | Busch Stadium II (28-25) | 52-51 | |
| » W: Jack Curtis (7-8) L: Randy Tate (4-9) | Fourth | 11 out |
| Thursday, July 31 |
| » Lost to Cubs (49-58), 5-3 | Wrigley Field (0-3) | 52-52 | |
| » W: Paul Reuschel (1-1) L: Ken Reynolds (0-1) | Fourth | 11 out |
| Former Cardinal Max Flack dies in Belleville, IL at the age of 86. |
| Friday, August 1 |
| » Defeated Cubs (49-59), 9-4 | Wrigley Field (1-3) | 53-52 | |
| » W: John Denny (5-3) L: Bill Bonham (10-7) S: Bob Gibson (1) | Fourth | 10 out |
| Saturday, August 2 |
| » Defeated Cubs (49-60), 4-0 | Wrigley Field (2-3) | 54-52 | Won 2 |
| » W: Bob Forsch (10-8) L: Rick Reuschel (7-12) | Fourth | 9 out |
| Sunday, August 3 |
| » Lost to Cubs (50-60), 6-3 | Wrigley Field (2-4) | 54-53 | |
| » W: Tom Dettore (4-3) L: Al Hrabosky (9-3) S: Darold Knowles (10) | Fourth | 10 out |
| » Defeated Cubs (50-61), 7-4 | Wrigley Field (3-4) | 55-53 | |
| » W: Ron Reed (10-9) L: Ray Burris (8-9) | Fourth | 10 out |
| Monday, August 4 |
| » Defeated Pirates (65-44), 5-4 | Busch Stadium II (29-25) | 56-53 | Won 2 |
| » W: Jack Curtis (8-8) L: Jerry Reuss (12-7) S: Al Hrabosky (15) | Fourth | 9 out |
| Tuesday, August 5 |
| » Lost to Pirates (66-44), 6-1 | Busch Stadium II (29-26) | 56-54 | |
| » W: Jim Rooker (8-7) L: Eric Rasmussen (1-2) | Fourth | 10 out |
| Wednesday, August 6 |
| » Defeated Pirates (66-45), 4-2 | Busch Stadium II (30-26) | 57-54 | |
| » W: John Denny (6-3) L: Ken Brett (7-4) S: Al Hrabosky (16) | Fourth | 9 out |
| Thursday, August 7 |
| Future Cardinal Edgar Renteria is born in Barranquilla, Colombia. |
| Friday, August 8 |
| » Defeated Padres (53-60), 10-6 | Busch Stadium II (31-26) | 58-54 | Won 2 |
| » W: Bob Forsch (11-8) L: Dan Spillner (4-10) | Third | 7½ out |
| Saturday, August 9 |
| » Defeated Padres (53-61), 6-1 | Busch Stadium II (32-26) | 59-54 | Won 3 |
| » W: Lynn McGlothen (12-8) L: Dave Freisleben (5-12) | Third | 6½ out |
| Sunday, August 10 |
| » Defeated Padres (53-62), 3-2 | Busch Stadium II (33-26) | 60-54 | Won 4 |
| » W: Al Hrabosky (10-3) L: Bill Greif (3-4) | Third | 5½ out |
| Monday, August 11 |
| » Lost to Astros (45-75), 7-2 | Astrodome (3-1) | 60-55 | |
| » W: Larry Dierker (10-12) L: Jack Curtis (8-9) | Third | 6½ out |
| Tuesday, August 12 |
| » Defeated Astros (45-76), 5-4 | Astrodome (4-1) | 61-55 | |
| » W: John Denny (7-3) L: Dave Roberts (7-13) S: Al Hrabosky (17) | Third | 5½ out |
| Future Cardinal Luis Ordaz is born in Maracaibo, Venezuela. Former Cardinal Lew Riggs dies in Durham, NC at the age of 66 |
| Wednesday, August 13 |
| » Defeated Astros (45-77), 4-3 | Astrodome (5-1) | 62-55 | Won 2 |
| » W: Mike Garman (3-4) L: Mike Cosgrove (0-1) S: Bob Gibson (2) | Third | 4½ out |
| Thursday, August 14 |
| » Lost to Braves (54-66), 6-4 | Atlanta-Fulton County Stadium (1-1) | 62-56 | |
| » W: Phil Niekro (12-10) L: Lynn McGlothen (12-9) S: Ray Sadecki (1) | Third | 4½ out |
| Friday, August 15 |
| » Defeated Braves (54-67), 4-1 | Atlanta-Fulton County Stadium (2-1) | 63-56 | |
| » W: Ron Reed (11-9) L: Jamie Easterly (1-6) | Third | 3 out |
| » Defeated Braves (54-68), 2-1 | Atlanta-Fulton County Stadium (3-1) | 64-56 | Won 2 |
| » W: Eric Rasmussen (2-2) L: Mike Thompson (0-4) S: Al Hrabosky (18) | Third | 3 out |
| Saturday, August 16 |
| » Lost to Braves (55-68), 8-7 | Atlanta-Fulton County Stadium (3-2) | 64-57 | |
| » W: Tom House (7-4) L: Bob Gibson (3-9) | Third | 3 out |
| Sunday, August 17 |
| » Defeated Braves (55-69), 8-1 | Atlanta-Fulton County Stadium (4-2) | 65-57 | |
| » W: John Denny (8-3) L: Blue Moon Odom (2-8) | Third | 2 out |
| Monday, August 18 |
| » Lost to Reds (83-39), 3-2 | Busch Stadium II (33-27) | 65-58 | |
| » W: Don Gullett (10-3) L: Bob Forsch (11-9) S: Rawly Eastwick (15) | Second | 2½ out |
| Tuesday, August 19 |
| » Defeated Reds (83-40), 2-1 | Busch Stadium II (34-27) | 66-58 | |
| » W: Lynn McGlothen (13-9) L: Gary Nolan (11-7) | Third | 2½ out |
| Wednesday, August 20 |
| » Defeated Reds (83-41), 4-0 | Busch Stadium II (35-27) | 67-58 | Won 2 |
| » W: Ron Reed (12-9) L: Fred Norman (8-4) | Third | 2½ out |
| Friday, August 22 |
| » Lost to Braves (57-71), 9-5 | Busch Stadium II (35-28) | 67-59 | |
| » W: Elias Sosa (1-5) L: Harry Parker (2-4) S: Tom House (11) | Third | 4 out |
| Saturday, August 23 |
| » Defeated Braves (57-72), 7-2 | Busch Stadium II (36-28) | 68-59 | |
| » W: John Denny (9-3) L: Phil Niekro (12-12) | Third | 3 out |
| Sunday, August 24 |
| » Defeated Braves (57-73), 6-2 | Busch Stadium II (37-28) | 69-59 | Won 2 |
| » W: Bob Forsch (12-9) L: Carl Morton (15-14) S: Al Hrabosky (19) | Second | 3 out |
| Monday, August 25 |
| » Tied Astros, 3-3 | Busch Stadium II (37-28) | 69-59 | |
| » Starters: Dave Roberts vs Lynn McGlothen | Third | 3½ out |
| Tuesday, August 26 |
| » Defeated Astros (50-83), 10-9 | Busch Stadium II (38-28) | 70-59 | Won 3 |
| » W: Al Hrabosky (11-3) L: Jose Sosa (0-2) | Second | 3 out |
| » Defeated Astros (50-84), 2-1 | Busch Stadium II (39-28) | 71-59 | Won 4 |
| » W: Eric Rasmussen (3-2) L: Doug Konieczny (5-12) | Second | 3 out |
| Wednesday, August 27 |
| » Lost to Astros (51-84), 5-1 | Busch Stadium II (39-29) | 71-60 | |
| » W: Jim York (2-2) L: John Denny (9-4) | Second | 3 out |
| Thursday, August 28 |
| » Lost to Reds (88-44), 4-0 | Riverfront Stadium (0-3) | 71-61 | Lost 2 |
| » W: Don Gullett (11-3) L: Mike Garman (3-5) | Second | 3½ out |
| Friday, August 29 |
| » Lost to Reds (89-44), 6-2 | Riverfront Stadium (0-4) | 71-62 | Lost 3 |
| » W: Gary Nolan (12-8) L: Lynn McGlothen (13-10) S: Will McEnaney (13) | Third | 4 out |
| Saturday, August 30 |
| » Lost to Reds (90-44), 3-2 | Riverfront Stadium (0-5) | 71-63 | Lost 4 |
| » W: Rawly Eastwick (4-2) L: Mike Garman (3-6) | Third | 4 out |
| Sunday, August 31 |
| » Defeated Reds (90-45), 5-3 | Riverfront Stadium (1-5) | 72-63 | |
| » W: Eric Rasmussen (4-2) L: Jack Billingham (14-7) S: Jack Curtis (1) | Second | 4 out |
| Monday, September 1 |
| » Defeated Cubs (62-75), 6-3 | Busch Stadium II (40-29) | 73-63 | Won 2 |
| » W: Bob Forsch (13-9) L: Bill Bonham (11-13) S: Al Hrabosky (20) | Second | 3 out |
| Tuesday, September 2 |
| » Lost to Cubs (63-75), 5-3 | Busch Stadium II (40-30) | 73-64 | |
| » W: Ray Burris (12-10) L: Lynn McGlothen (13-11) S: Paul Reuschel (2) | Second | 4 out |
| » Major-league debuts: Joe Wallis (Cubs) |
| Wednesday, September 3 |
| » Lost to Cubs (64-75), 11-6 | Busch Stadium II (40-31) | 73-65 | Lost 2 |
| » W: Buddy Schultz (1-0) L: Bob Gibson (3-10) S: Paul Reuschel (3) | Second | 5 out |
| » Major-league debuts: Buddy Schultz (Cubs) |
| Friday, September 5 |
| » Lost to Mets (73-66), 5-2 | Shea Stadium (2-5) | 73-66 | Lost 3 |
| » W: Tom Seaver (21-7) L: Eric Rasmussen (4-3) S: Bob Apodaca (13) | Third | 5½ out |
| Saturday, September 6 |
| » Defeated Mets (73-67), 6-3 | Shea Stadium (3-5) | 74-66 | |
| » W: Bob Forsch (14-9) L: Jerry Koosman (11-13) S: Al Hrabosky (21) | Second | 5½ out |
| Sunday, September 7 |
| » Defeated Mets (73-68), 12-4 | Shea Stadium (4-5) | 75-66 | Won 2 |
| » W: Lynn McGlothen (14-11) L: Jon Matlack (16-10) | Second | 5½ out |
| Monday, September 8 |
| » Lost to Phillies (75-68), 6-3 | Veteran's Stadium (4-4) | 75-67 | |
| » W: Tom Underwood (14-10) L: Ron Reed (12-10) S: Tug McGraw (13) | Second | 6½ out |
| Tuesday, September 9 |
| » Lost to Phillies (76-68), 6-2 | Veteran's Stadium (4-5) | 75-68 | Lost 2 |
| » W: Steve Carlton (12-13) L: John Denny (9-5) | Third | 6½ out |
| Wednesday, September 10 |
| » Lost to Cubs (69-77), 7-5 | Wrigley Field (3-5) | 75-69 | Lost 3 |
| » W: Buddy Schultz (2-0) L: Eric Rasmussen (4-4) S: Darold Knowles (13) | Third | 7½ out |
| Thursday, September 11 |
| » Lost to Cubs (70-77), 12-6 | Wrigley Field (3-6) | 75-70 | Lost 4 |
| » W: Oscar Zamora (5-2) L: Bob Forsch (14-10) S: Darold Knowles (14) | Third | 7½ out |
| Friday, September 12 |
| » Defeated Mets (74-73), 5-1 | Busch Stadium II (41-31) | 76-70 | |
| » W: Lynn McGlothen (15-11) L: Jon Matlack (16-11) | Third | 7½ out |
| » Major-league debuts: Roy Staiger (Mets) |
| Saturday, September 13 |
| » Lost to Mets (75-73), 6-2 | Busch Stadium II (41-32) | |