| Monday, January 14 |
| Former Red Sox Lloyd Brown dies in Opa-Locka, FL at the age of 70. |
| Friday, January 18 |
| Former Red Sox Pete Appleton dies in Trenton, NJ at the age of 70. |
| Sunday, January 27 |
| Future Red Sox Bry Nelson is born in Crossett, AR. |
| Friday, February 15 |
| Future Red Sox Ugueth Urbina is born in Caracas, Venezuela. |
| Tuesday, February 19 |
| Future Red Sox Juan Diaz is born in San Jose de las Lajas, Cuba. |
| Wednesday, March 6 |
| Future Red Sox James Lofton is born in Los Angeles, CA. |
| Thursday, April 4 |
| » Major-league debuts: Jim Sundberg (Rangers) |
| Friday, April 5 |
| » Defeated Brewers (0-1), 9-8 | County Stadium (1-0) | 1-0 | |
| » W: Diego Segui (1-0) L: Kevin Kobel (0-1) | First | -- |
| » Major-league debuts: Robin Yount (Brewers) |
| Saturday, April 6 |
| » Lost to Brewers (1-1), 5-4 | County Stadium (1-1) | 1-1 | |
| » W: Jim Slaton (1-0) L: Bill Lee (0-1) S: Eduardo Rodriguez (1) | Second | ½ out |
| Thursday, April 11 |
| » Lost to Orioles (3-2), 7-6 | Fenway Park (0-1) | 1-2 | Lost 2 |
| » W: Bob Reynolds (1-0) L: Diego Segui (1-1) | Fifth | 2 out |
| Future Red Sox Trot Nixon is born in Durham, NC. |
| Friday, April 12 |
| » Defeated Tigers (3-4), 6-3 | Fenway Park (1-1) | 2-2 | |
| » W: Bill Lee (1-1) L: Lerrin LaGrow (0-1) | Third | 1 out |
| Saturday, April 13 |
| » Defeated Tigers (3-5), 8-1 | Fenway Park (2-1) | 3-2 | Won 2 |
| » W: Rick Wise (1-0) L: Bill Slayback (0-1) | Second | ½ out |
| Sunday, April 14 |
| » Defeated Tigers (3-6), 7-5 | Fenway Park (3-1) | 4-2 | Won 3 |
| » W: Dick Drago (1-0) L: Mickey Lolich (0-3) S: Diego Segui (1) | First | -- |
| Monday, April 15 |
| » Lost to Tigers (4-6), 1-0 | Fenway Park (3-2) | 4-3 | |
| » W: Joe Coleman (2-0) L: Reggie Cleveland (0-1) | Second | 1 out |
| Tuesday, April 16 |
| » Lost to Yankees (6-4), 2-1 | Shea Stadium (0-1) | 4-4 | Lost 2 |
| » W: Mel Stottlemyre (2-1) L: Luis Tiant (0-1) | Third | 1 out |
| Wednesday, April 17 |
| » Defeated Yankees (6-5), 4-3 | Shea Stadium (1-1) | 5-4 | |
| » W: Bill Lee (2-1) L: Pat Dobson (1-2) | Second | 1 out |
| Thursday, April 18 |
| » Lost to Yankees (7-5), 6-1 | Shea Stadium (1-2) | 5-5 | |
| » W: Doc Medich (2-1) L: Rick Wise (1-1) | Fourth | 1½ out |
| Friday, April 19 |
| » Defeated Indians (4-8), 6-3 | Fenway Park (4-2) | 6-5 | |
| » W: Reggie Cleveland (1-1) L: Dick Tidrow (1-2) S: Dick Drago (1) | Third | 1 out |
| Saturday, April 20 |
| » Defeated Indians (4-9), 5-4 | Fenway Park (5-2) | 7-5 | Won 2 |
| » W: Luis Tiant (1-1) L: Bob Johnson (0-2) | Second | 1 out |
| Sunday, April 21 |
| » Defeated Indians (4-10), 6-5 | Fenway Park (6-2) | 8-5 | Won 3 |
| » W: Diego Segui (2-1) L: Cecil Upshaw (0-1) | Second | 1 out |
| Monday, April 22 |
| » Defeated Royals (4-8), 4-1 | Fenway Park (7-2) | 9-5 | Won 4 |
| » W: Rick Wise (2-1) L: Nelson Briles (0-1) S: Diego Segui (2) | First | -- |
| Tuesday, April 23 |
| » Lost to Royals (5-8), 5-2 | Fenway Park (7-3) | 9-6 | |
| » W: Al Fitzmorris (1-0) L: Dick Drago (1-1) | First | -- |
| Wednesday, April 24 |
| » Lost to Rangers (9-6), 3-1 | Arlington Stadium (0-1) | 9-7 | Lost 2 |
| » W: Fergie Jenkins (4-1) L: Reggie Cleveland (1-2) | Third | ½ out |
| Thursday, April 25 |
| » Lost to Rangers (10-6), 4-0 | Arlington Stadium (0-2) | 9-8 | Lost 3 |
| » W: Jim Bibby (4-2) L: Luis Tiant (1-2) | Fourth | 1 out |
| Friday, April 26 |
| » Lost to Royals (7-9), 4-2 | Royals Stadium (0-1) | 9-9 | Lost 4 |
| » W: Steve Busby (3-2) L: Bill Lee (2-2) | Fourth | 2 out |
| Saturday, April 27 |
| » Lost to Royals (8-9), 10-3 | Royals Stadium (0-2) | 9-10 | Lost 5 |
| » W: Al Fitzmorris (2-0) L: Juan Marichal (0-1) | Fourth | 2 out |
| Sunday, April 28 |
| » Defeated Royals (8-10), 5-4 | Royals Stadium (1-2) | 10-10 | |
| » W: Dick Drago (2-1) L: Doug Bird (0-1) | Fourth | 2 out |
| Monday, April 29 |
| » Lost to Angels (10-11), 7-2 | Fenway Park (7-4) | 10-11 | |
| » W: Bill Singer (3-2) L: Luis Tiant (1-3) | Fourth | 2½ out |
| Tuesday, April 30 |
| » Lost to Angels (11-11), 16-6 | Fenway Park (7-5) | 10-12 | Lost 2 |
| » W: Nolan Ryan (3-3) L: Reggie Cleveland (1-3) | Sixth | 2½ out |
| Wednesday, May 1 |
| » Lost to Angels (12-11), 4-2 | Fenway Park (7-6) | 10-13 | Lost 3 |
| » W: Bill Stoneman (1-1) L: Bill Lee (2-3) S: Rudy May (1) | Sixth | 3½ out |
| Saturday, May 4 |
| » Lost to Rangers (14-9), 1-0 | Fenway Park (7-7) | 10-14 | Lost 4 |
| » W: Fergie Jenkins (6-1) L: Rick Wise (2-2) | Sixth | 4 out |
| » Major-league debuts: Rick Burleson (Red Sox) |
| Sunday, May 5 |
| » Lost to Rangers (15-9), 5-3 | Fenway Park (7-8) | 10-15 | Lost 5 |
| » W: Steve Hargan (2-3) L: Luis Tiant (1-4) S: Steve Foucault (1) | Sixth | 3½ out |
| » Defeated Rangers (15-10), 10-8 | Fenway Park (8-8) | 11-15 | |
| » W: Juan Marichal (1-1) L: Jim Bibby (5-3) | Sixth | 3½ out |
| Wednesday, May 8 |
| » Defeated Yankees (17-13), 4-0 | Fenway Park (9-8) | 12-15 | Won 2 |
| » W: Bill Lee (3-3) L: Mel Stottlemyre (5-3) | Fifth | 3½ out |
| Thursday, May 9 |
| » Defeated Yankees (17-14), 2-0 | Fenway Park (10-8) | 13-15 | Won 3 |
| » W: Luis Tiant (2-4) L: Pat Dobson (2-5) | Fourth | 2½ out |
| Friday, May 10 |
| » Lost to Tigers (14-13), 6-5 | Tiger Stadium (0-1) | 13-16 | |
| » W: John Hiller (5-0) L: Diego Segui (2-2) | Fourth | 3½ out |
| Saturday, May 11 |
| » Defeated Tigers (14-14), 8-5 | Tiger Stadium (1-1) | 14-16 | |
| » W: Lance Clemons (1-0) L: John Hiller (5-1) | Fifth | 2½ out |
| Sunday, May 12 |
| » Defeated Tigers (14-15), 4-3 | Tiger Stadium (2-1) | 15-16 | Won 2 |
| » W: Bill Lee (4-3) L: John Hiller (5-2) S: Diego Segui (3) | Fifth | 1½ out |
| Monday, May 13 |
| » Lost to Indians (16-15), 4-1 | Cleveland Stadium (0-1) | 15-17 | |
| » W: Jim Perry (3-2) L: Luis Tiant (2-5) S: Tom Buskey (4) | Sixth | 2½ out |
| Tuesday, May 14 |
| » Lost to Indians (17-15), 6-2 | Cleveland Stadium (0-2) | 15-18 | Lost 2 |
| » W: Gaylord Perry (5-1) L: Reggie Cleveland (1-4) | Fifth | 2½ out |
| Wednesday, May 15 |
| » Defeated Indians (17-16), 7-4 | Cleveland Stadium (1-2) | 16-18 | |
| » W: Juan Marichal (2-1) L: Steve Kline (3-5) | Fifth | 2½ out |
| Friday, May 17 |
| » Lost to Orioles (17-15), 6-0 | Memorial Stadium (0-1) | 16-19 | |
| » W: Mike Cuellar (3-3) L: Bill Lee (4-4) | Fifth | 2½ out |
| Saturday, May 18 |
| » Defeated Orioles (17-16), 10-2 | Memorial Stadium (1-1) | 17-19 | |
| » W: Luis Tiant (3-5) L: Ross Grimsley (4-4) | Sixth | 2½ out |
| Sunday, May 19 |
| » Defeated Orioles (17-17), 11-2 | Memorial Stadium (2-1) | 18-19 | Won 2 |
| » W: Reggie Cleveland (2-4) L: Dave McNally (3-3) | Fourth | 2½ out |
| » Defeated Orioles (17-18), 6-4 | Memorial Stadium (3-1) | 19-19 | Won 3 |
| » W: Dick Drago (3-1) L: Doyle Alexander (1-1) | Fourth | 2½ out |
| Tuesday, May 21 |
| » Defeated Yankees (20-22), 14-6 | Fenway Park (11-8) | 20-19 | Won 4 |
| » W: Bill Lee (5-4) L: Dick Tidrow (3-4) | Second | 2 out |
| Wednesday, May 22 |
| » Defeated Yankees (20-23), 6-3 | Fenway Park (12-8) | 21-19 | Won 5 |
| » W: Luis Tiant (4-5) L: Doc Medich (6-3) | Second | 2 out |
| Friday, May 24 |
| » Defeated Brewers (20-18), 5-3 | Fenway Park (13-8) | 22-19 | Won 6 |
| » W: Dick Drago (4-1) L: Bill Champion (2-1) | First | -- |
| Saturday, May 25 |
| » Lost to Brewers (21-18), 9-2 | Fenway Park (13-9) | 22-20 | |
| » W: Clyde Wright (5-5) L: Reggie Cleveland (2-5) | Third | 1½ out |
| Sunday, May 26 |
| » Defeated Brewers (21-19), 4-1 | Fenway Park (14-9) | 23-20 | |
| » W: Bill Lee (6-4) L: Ed Sprague (2-1) | First | -- |
| Monday, May 27 |
| » Defeated Twins (18-22), 3-2 | Fenway Park (15-9) | 24-20 | Won 2 |
| » W: Luis Tiant (5-5) L: Tom Burgmeier (0-2) | First | -- |
| Tuesday, May 28 |
| » Defeated Twins (18-23), 9-5 | Fenway Park (16-9) | 25-20 | Won 3 |
| » W: Reggie Cleveland (3-5) L: Bert Blyleven (4-7) | First | -- |
| Wednesday, May 29 |
| » Lost to Twins (19-23), 5-4 | Fenway Park (16-10) | 25-21 | |
| » W: Tom Burgmeier (1-2) L: Diego Segui (2-3) | Second | 1½ out |
| Friday, May 31 |
| » Lost to White Sox (22-21), 3-2 | Fenway Park (16-11) | 25-22 | Lost 2 |
| » W: Wilbur Wood (8-6) L: Bill Lee (6-5) S: Terry Forster (10) | Second | 1½ out |
| Saturday, June 1 |
| » Defeated White Sox (22-22), 8-0 | Fenway Park (17-11) | 26-22 | |
| » W: Luis Tiant (6-5) L: Stan Bahnsen (5-5) | First | -- |
| Sunday, June 2 |
| » Defeated White Sox (22-23), 9-7 | Fenway Park (18-11) | 27-22 | Won 2 |
| » W: Reggie Cleveland (4-5) L: Jim Kaat (4-6) | First | -- |
| Monday, June 3 |
| » Lost to Twins (21-25), 5-4 | Metropolitan Stadium (0-1) | 27-23 | |
| » W: Bill Hands (1-4) L: Diego Segui (2-4) | First | -- |
| Tuesday, June 4 |
| » Defeated Twins (21-26), 4-3 | Metropolitan Stadium (1-1) | 28-23 | |
| » W: Diego Segui (3-4) L: Bill Campbell (2-4) S: Roger Moret (1) | First | -- |
| Wednesday, June 5 |
| » Defeated Twins (21-27), 5-3 | Metropolitan Stadium (2-1) | 29-23 | Won 2 |
| » W: Luis Tiant (7-5) L: Dave Goltz (1-1) | First | -- |
| Friday, June 7 |
| » Lost to White Sox (25-24), 8-6 | Comiskey Park I (0-1) | 29-24 | |
| » W: Jim Kaat (5-6) L: Roger Moret (0-1) S: Cy Acosta (3) | First | -- |
| » Major-league debuts: Joe Henderson (White Sox) |
| Saturday, June 8 |
| » Lost to White Sox (26-24), 13-6 | Comiskey Park I (0-2) | 29-25 | Lost 2 |
| » W: Wilbur Wood (10-6) L: Bob Veale (0-1) | Second | 1½ out |
| Sunday, June 9 |
| » Defeated White Sox (26-25), 10-6 | Comiskey Park I (1-2) | 30-25 | |
| » W: Bill Lee (7-5) L: Skip Pitlock (2-1) | First | -- |
| Monday, June 10 |
| » Defeated Athletics (32-25), 4-1 | Fenway Park (19-11) | 31-25 | Won 2 |
| » W: Luis Tiant (8-5) L: Vida Blue (5-6) | First | -- |
| Tuesday, June 11 |
| » Defeated Athletics (32-26), 10-9 | Fenway Park (20-11) | 32-25 | Won 3 |
| » W: Diego Segui (4-4) L: Catfish Hunter (8-7) S: Bob Veale (1) | First | -- |
| Wednesday, June 12 |
| » Defeated Athletics (32-27), 5-3 | Fenway Park (21-11) | 33-25 | Won 4 |
| » W: Dick Drago (5-1) L: Darold Knowles (1-1) | First | -- |
| Friday, June 14 |
| » Lost to Angels (27-34), 4-3 | Anaheim Stadium (0-1) | 33-26 | |
| » W: Barry Raziano (1-0) L: Luis Tiant (8-6) | First | -- |
| Saturday, June 15 |
| » Defeated Angels (27-35), 5-3 | Anaheim Stadium (1-1) | 34-26 | |
| » W: Bill Lee (8-5) L: Bill Stoneman (1-5) S: Diego Segui (4) | First | -- |
| Sunday, June 16 |
| » Defeated Angels (27-36), 7-4 | Anaheim Stadium (2-1) | 35-26 | Won 2 |
| » W: Reggie Cleveland (5-5) L: Barry Raziano (1-1) | First | -- |
| Monday, June 17 |
| » Lost to Athletics (34-29), 3-2 | Oakland-Alameda County Stadium (0-1) | 35-27 | |
| » W: Rollie Fingers (6-2) L: Dick Drago (5-2) | First | -- |
| Tuesday, June 18 |
| » Defeated Athletics (34-30), 6-1 | Oakland-Alameda County Stadium (1-1) | 36-27 | |
| » W: Roger Moret (1-1) L: Ken Holtzman (7-8) | First | -- |
| Wednesday, June 19 |
| » Defeated Athletics (34-31), 2-1 | Oakland-Alameda County Stadium (2-1) | 37-27 | Won 2 |
| » W: Luis Tiant (9-6) L: Vida Blue (6-7) S: Diego Segui (5) | First | -- |
| Saturday, June 22 |
| » Lost to Indians (33-30), 11-0 | Fenway Park (21-12) | 37-28 | |
| » W: Gaylord Perry (13-1) L: Bill Lee (8-6) | First | -- |
| » Defeated Indians (33-31), 8-3 | Fenway Park (22-12) | 38-28 | |
| » W: Reggie Cleveland (6-5) L: Jim Perry (5-7) S: Roger Moret (2) | First | -- |
| Sunday, June 23 |
| » Defeated Indians (33-32), 8-0 | Fenway Park (23-12) | 39-28 | Won 2 |
| » W: Rick Wise (3-2) L: Steve Kline (5-9) S: Dick Drago (2) | First | -- |
| Monday, June 24 |
| » Defeated Brewers (32-33), 9-0 | Fenway Park (24-12) | 40-28 | Won 3 |
| » W: Luis Tiant (10-6) L: Jim Colborn (3-4) | First | -- |
| Wednesday, June 26 |
| » Lost to Brewers (33-33), 7-1 | Fenway Park (24-13) | 40-29 | |
| » W: Ed Sprague (4-1) L: Bill Lee (8-7) | First | -- |
| Thursday, June 27 |
| » Lost to Indians (36-32), 2-1 | Cleveland Stadium (1-3) | 40-30 | Lost 2 |
| » W: Jim Perry (6-7) L: Roger Moret (1-2) S: Tom Buskey (5) | First | -- |
| Friday, June 28 |
| » Lost to Indians (37-32), 2-1 | Cleveland Stadium (1-4) | 40-31 | Lost 3 |
| » W: Gaylord Perry (14-1) L: Dick Drago (5-3) | First | -- |
| Saturday, June 29 |
| » Defeated Indians (37-33), 12-2 | Cleveland Stadium (2-4) | 41-31 | |
| » W: Luis Tiant (11-6) L: Fritz Peterson (5-4) | First | -- |
| Sunday, June 30 |
| » Lost to Indians (38-33), 9-2 | Cleveland Stadium (2-5) | 41-32 | |
| » W: Steve Arlin (3-8) L: Rick Wise (3-3) | First | -- |
| Monday, July 1 |
| » Defeated Orioles (38-35), 6-4 | Memorial Stadium (4-1) | 42-32 | |
| » W: Bill Lee (9-7) L: Doyle Alexander (3-4) S: Diego Segui (6) | First | -- |
| Tuesday, July 2 |
| » Defeated Orioles (38-36), 9-6 | Memorial Stadium (5-1) | 43-32 | Won 2 |
| » W: Diego Segui (5-4) L: Dave Johnson (0-1) | First | -- |
| » Major-league debuts: Dave Johnson (Orioles) |
| Wednesday, July 3 |
| » Lost to Orioles (39-36), 9-2 | Fenway Park (24-14) | 43-33 | |
| » W: Doyle Alexander (4-4) L: Dick Drago (5-4) | Second | 1 out |
| » Lost to Orioles (40-36), 6-4 | Fenway Park (24-15) | 43-34 | Lost 2 |
| » W: Wayne Garland (2-1) L: Reggie Cleveland (6-6) S: Dave McNally (1) | Second | 1 out |
| » Major-league debuts: Tim Blackwell (Red Sox) |
| Thursday, July 4 |
| » Lost to Orioles (41-36), 10-6 | Fenway Park (24-16) | 43-35 | Lost 3 |
| » W: Jesse Jefferson (1-0) L: Luis Tiant (11-7) | Second | 1 out |
| Saturday, July 6 |
| » Lost to Royals (40-38), 5-3 | Fenway Park (24-17) | 43-36 | Lost 4 |
| » W: Nelson Briles (1-2) L: Rick Wise (3-4) S: Al Fitzmorris (1) | Second | 1½ out |
| Sunday, July 7 |
| » Lost to Royals (41-38), 11-9 | Fenway Park (24-18) | 43-37 | Lost 5 |
| » W: Joe Hoerner (2-3) L: Don Newhauser (0-1) | Second | 2 out |
| » Defeated Royals (41-39), 5-3 | Fenway Park (25-18) | 44-37 | |
| » W: Roger Moret (2-2) L: Marty Pattin (2-4) | Second | 2 out |
| Monday, July 8 |
| » Lost to Royals (42-39), 5-0 | Fenway Park (25-19) | 44-38 | |
| » W: Steve Busby (11-8) L: Dick Drago (5-5) | Third | 2 out |
| Tuesday, July 9 |
| » Defeated Rangers (41-44), 2-1 | Fenway Park (26-19) | 45-38 | |
| » W: Luis Tiant (12-7) L: Jim Bibby (11-11) | Third | 1 out |
| Wednesday, July 10 |
| » Defeated Rangers (41-45), 3-1 | Fenway Park (27-19) | 46-38 | Won 2 |
| » W: Reggie Cleveland (7-6) L: David Clyde (3-6) | Third | 1½ out |
| Thursday, July 11 |
| » Defeated Rangers (41-46), 12-3 | Fenway Park (28-19) | 47-38 | Won 3 |
| » W: Bill Lee (10-7) L: Steve Hargan (7-5) | First | -- |
| Friday, July 12 |
| » Lost to Angels (33-56), 7-0 | Fenway Park (28-20) | 47-39 | |
| » W: Ed Figueroa (1-1) L: Roger Moret (2-3) | Second | 1½ out |
| Saturday, July 13 |
| » Lost to Angels (34-56), 12-1 | Fenway Park (28-21) | 47-40 | Lost 2 |
| » W: Andy Hassler (2-4) L: Dick Drago (5-6) | Third | 1½ out |
| Sunday, July 14 |
| » Defeated Angels (34-57), 3-0 | Fenway Park (29-21) | 48-40 | |
| » W: Luis Tiant (13-7) L: Dick Lange (3-6) | First | -- |
| Monday, July 15 |
| » Lost to Royals (45-43), 3-2 | Royals Stadium (1-3) | 48-41 | |
| » W: Nelson Briles (2-3) L: Reggie Cleveland (7-7) S: Doug Bird (5) | First | -- |
| Tuesday, July 16 |
| » Lost to Royals (46-43), 5-4 | Royals Stadium (1-4) | 48-42 | Lost 2 |
| » W: Steve Busby (13-8) L: Bill Lee (10-8) | First | -- |
| Wednesday, July 17 |
| » Defeated Royals (46-44), 6-3 | Royals Stadium (2-4) | 49-42 | |
| » W: Roger Moret (3-3) L: Marty Pattin (2-5) | First | -- |
| Thursday, July 18 |
| » Lost to Rangers (45-49), 2-1 | Arlington Stadium (0-3) | 49-43 | |
| » W: Fergie Jenkins (12-9) L: Dick Drago (5-7) | First | -- |
| Friday, July 19 |
| » Defeated Rangers (45-50), 3-1 | Arlington Stadium (1-3) | 50-43 | |
| » W: Luis Tiant (14-7) L: Jackie Brown (7-8) | First | -- |
| Saturday, July 20 |
| » Lost to Rangers (46-50), 8-6 | Arlington Stadium (1-4) | 50-44 | |
| » W: Jim Bibby (13-12) L: Reggie Cleveland (7-8) | First | -- |
| Sunday, July 21 |
| » Lost to Rangers (47-50), 2-1 | Arlington Stadium (1-5) | 50-45 | Lost 2 |
| » W: Steve Hargan (9-5) L: Bill Lee (10-9) S: Steve Foucault (9) | First | -- |
| Thursday, July 25 |
| » Defeated Tigers (45-51), 12-4 | Tiger Stadium (3-1) | 51-45 | |
| » W: Roger Moret (4-3) L: Mickey Lolich (10-13) S: Dick Drago (3) | Second | 1 out |
| Friday, July 26 |
| » Lost to Tigers (46-51), 1-0 | Tiger Stadium (3-2) | 51-46 | |
| » W: Joe Coleman (9-9) L: Reggie Cleveland (7-9) | First | -- |
| Saturday, July 27 |
| » Defeated Yankees (50-48), 5-4 | Fenway Park (30-21) | 52-46 | |
| » W: Luis Tiant (15-7) L: Sparky Lyle (6-2) | First | -- |
| Sunday, July 28 |
| » Defeated Yankees (50-49), 8-3 | Fenway Park (31-21) | 53-46 | Won 2 |
| » W: Bill Lee (11-9) L: Dave Pagan (1-2) | First | -- |
| Monday, July 29 |
| » Defeated Yankees (50-50), 2-1 | Fenway Park (32-21) | 54-46 | Won 3 |
| » W: Roger Moret (5-3) L: Sparky Lyle (6-3) | First | -- |
| Tuesday, July 30 |
| » Lost to Tigers (49-52), 7-5 | Fenway Park (32-22) | 54-47 | |
| » W: John Hiller (13-7) L: Reggie Cleveland (7-10) | First | -- |
| Wednesday, July 31 |
| » Defeated Tigers (49-53), 5-4 | Fenway Park (33-22) | 55-47 | |
| » W: Luis Tiant (16-7) L: Lerrin LaGrow (7-11) | First | -- |
| Thursday, August 1 |
| » Defeated Orioles (52-51), 11-3 | Fenway Park (34-22) | 56-47 | Won 2 |
| » W: Bill Lee (12-9) L: Wayne Garland (3-5) | First | -- |
| Friday, August 2 |
| » Defeated Orioles (52-52), 7-5 | Fenway Park (35-22) | 57-47 | Won 3 |
| » W: Juan Marichal (3-1) L: Doyle Alexander (4-8) | First | -- |
| Saturday, August 3 |
| » Lost to Yankees (52-54), 6-2 | Shea Stadium (1-3) | 57-48 | |
| » W: Pat Dobson (9-13) L: Roger Moret (5-4) | First | -- |
| Sunday, August 4 |
| » Defeated Yankees (52-55), 7-3 | Shea Stadium (2-3) | 58-48 | |
| » W: Luis Tiant (17-7) L: Doc Medich (13-9) | First | -- |
| Monday, August 5 |
| » Lost to Yankees (53-55), 8-0 | Shea Stadium (2-4) | 58-49 | |
| » W: Rudy May (3-2) L: Bill Lee (12-10) | First | -- |
| Tuesday, August 6 |
| » Defeated Brewers (52-57), 6-3 | County Stadium (2-1) | 59-49 | |
| » W: Reggie Cleveland (8-10) L: Jim Slaton (8-13) S: Diego Segui (7) | First | -- |
| » Defeated Brewers (52-58), 6-0 | County Stadium (3-1) | 60-49 | Won 2 |
| » W: Juan Marichal (4-1) L: Clyde Wright (8-16) | First | -- |
| Wednesday, August 7 |
| » Defeated Brewers (52-59), 1-0 | County Stadium (4-1) | 61-49 | Won 3 |
| » W: Roger Moret (6-4) L: Jim Colborn (6-10) S: Bob Veale (2) | First | -- |
| Thursday, August 8 |
| » Lost to Brewers (53-59), 5-3 | County Stadium (4-2) | 61-50 | |
| » W: Bill Champion (6-2) L: Luis Tiant (17-8) | First | -- |
| Friday, August 9 |
| » Defeated Athletics (66-48), 6-2 | Oakland-Alameda County Stadium (3-1) | 62-50 | |
| » W: Bill Lee (13-10) L: Ken Holtzman (12-13) | First | -- |
| Saturday, August 10 |
| » Lost to Athletics (67-48), 5-3 | Oakland-Alameda County Stadium (3-2) | 62-51 | |
| » W: Vida Blue (14-9) L: Reggie Cleveland (8-11) | First | -- |
| Sunday, August 11 |
| » Defeated Athletics (67-49), 2-1 | Oakland-Alameda County Stadium (4-2) | 63-51 | |
| » W: Juan Marichal (5-1) L: Glenn Abbott (4-3) | First | -- |
| Monday, August 12 |
| » Lost to Angels (46-71), 4-2 | Anaheim Stadium (2-2) | 63-52 | |
| » W: Nolan Ryan (15-12) L: Roger Moret (6-5) | First | -- |
| Tuesday, August 13 |
| » Defeated Angels (46-72), 3-0 | Anaheim Stadium (3-2) | 64-52 | |
| » W: Luis Tiant (18-8) L: Ed Figueroa (2-4) | First | -- |
| Wednesday, August 14 |
| » Lost to Angels (47-72), 5-0 | Anaheim Stadium (3-3) | 64-53 | |
| » W: Frank Tanana (8-14) L: Bill Lee (13-11) | First | -- |
| Friday, August 16 |
| » Defeated Twins (58-62), 3-2 | Fenway Park (36-22) | 65-53 | |
| » W: Diego Segui (6-4) L: Bill Campbell (6-7) | First | -- |
| Saturday, August 17 |
| » Lost to Twins (59-62), 7-4 | Fenway Park (36-23) | 65-54 | |
| » W: Dave Goltz (6-6) L: Reggie Cleveland (8-12) S: Tom Burgmeier (3) | First | -- |
| Sunday, August 18 |
| » Defeated Twins (59-63), 9-6 | Fenway Park (37-23) | 66-54 | |
| » W: Luis Tiant (19-8) L: Ray Corbin (6-5) | First | -- |
| Monday, August 19 |
| » Defeated White Sox (60-62), 6-1 | Fenway Park (38-23) | 67-54 | Won 2 |
| » W: Bill Lee (14-11) L: Jim Kaat (13-11) S: Diego Segui (8) | First | -- |
| » Major-league debuts: Jim Rice (Red Sox) |
| Tuesday, August 20 |
| » Defeated White Sox (60-63), 8-3 | Fenway Park (39-23) | 68-54 | Won 3 |
| » W: Dick Drago (6-7) L: Stan Bahnsen (11-14) | First | -- |
| Wednesday, August 21 |
| » Defeated White Sox (60-64), 4-0 | Fenway Park (40-23) | 69-54 | Won 4 |
| » W: Roger Moret (7-5) L: Wilbur Wood (18-15) | First | -- |
| Friday, August 23 |
| » Defeated Athletics (71-55), 3-0 | Fenway Park (41-23) | 70-54 | Won 5 |
| » W: Luis Tiant (20-8) L: Vida Blue (14-12) | First | -- |
| Saturday, August 24 |
| » Lost to Athletics (72-55), 4-1 | Fenway Park (41-24) | 70-55 | |
| » W: Catfish Hunter (19-10) L: Diego Segui (6-5) | First | -- |
| Sunday, August 25 |
| » Lost to Athletics (73-55), 7-0 | Fenway Park (41-25) | 70-56 | Lost 2 |
| » W: Ken Holtzman (15-13) L: Roger Moret (7-6) | First | -- |
| Tuesday, August 27 |
| » Defeated White Sox (64-65), 6-1 | Comiskey Park I (2-2) | 71-56 | |
| » W: Reggie Cleveland (9-12) L: Jim Kaat (14-12) | First | -- |
| Wednesday, August 28 |
| » Lost to White Sox (65-65), 3-0 | Comiskey Park I (2-3) | 71-57 | |
| » W: Bart Johnson (6-2) L: Luis Tiant (20-9) | First | -- |
| Thursday, August 29 |
| » Defeated White Sox (65-66), 3-2 | Comiskey Park I (3-3) | 72-57 | |
| » W: Bill Lee (15-11) L: Wilbur Wood (19-16) S: Diego Segui (9) | First | -- |
| Friday, August 30 |
| » Lost to Twins (64-68), 3-2 | Metropolitan Stadium (2-2) | 72-58 | |
| » W: Bert Blyleven (13-15) L: Roger Moret (7-7) | First | -- |
| Saturday, August 31 |
| » Lost to Twins (65-68), 6-2 | Metropolitan Stadium (2-3) | 72-59 | Lost 2 |
| » W: Dave Goltz (7-7) L: Dick Drago (6-8) | First | -- |
| Sunday, September 1 |
| » Lost to Twins (66-68), 9-6 | Metropolitan Stadium (2-4) | 72-60 | Lost 3 |
| » W: Bill Campbell (7-7) L: Diego Segui (6-6) | First | -- |
| Monday, September 2 |
| » Lost to Orioles (68-65), 1-0 | Memorial Stadium (5-2) | 72-61 | Lost 4 |
| » W: Ross Grimsley (16-12) L: Luis Tiant (20-10) | First | -- |
| » Lost to Orioles (69-65), 1-0 | Memorial Stadium (5-3) | 72-62 | Lost 5 |
| » W: Mike Cuellar (17-10) L: Bill Lee (15-12) | First | -- |
| Wednesday, September 4 |
| » Lost to Orioles (70-65), 6-0 | Memorial Stadium (5-4) | 72-63 | Lost 6 |
| » W: Jim Palmer (6-10) L: Roger Moret (7-8) | First | -- |
| Thursday, September 5 |
| » Lost to Brewers (66-72), 4-3 | Fenway Park (41-26) | 72-64 | Lost 7 |
| » W: Bill Champion (10-3) L: Diego Segui (6-7) S: Tom Murphy (18) | Second | ½ out |
| » Major-league debuts: Fred Lynn (Red Sox) |
| Friday, September 6 |
| » Lost to Brewers (67-72), 2-0 | Fenway Park (41-27) | 72-65 | Lost 8 |
| » W: Jim Slaton (11-14) L: Luis Tiant (20-11) S: Tom Murphy (19) | Second | 1½ out |
| Saturday, September 7 |
| » Defeated Brewers (67-73), 4-3 | Fenway Park (42-27) | 73-65 | |
| » W: Reggie Cleveland (10-12) L: Tom Murphy (7-6) | Second | 1 out |
| Sunday, September 8 |
| » Defeated Brewers (67-74), 8-6 | Fenway Park (43-27) | 74-65 | Won 2 |
| » W: Dick Pole (1-0) L: Clyde Wright (8-19) S: Diego Segui (10) | First | -- |
| Monday, September 9 |
| » Lost to Yankees (75-65), 6-3 | Fenway Park (43-28) | 74-66 | |
| » W: Doc Medich (18-12) L: Roger Moret (7-9) | Second | 1 out |
| Tuesday, September 10 |
| » Lost to Yankees (76-65), 2-1 | Fenway Park (43-29) | 74-67 | Lost 2 |
| » W: Pat Dobson (16-14) L: Diego Segui (6-8) S: Sparky Lyle (14) | Second | 2 out |
| Wednesday, September 11 |
| » Lost to Indians (71-69), 3-1 | Cleveland Stadium (2-6) | 74-68 | Lost 3 |
| » W: Gaylord Perry (19-10) L: Dick Drago (6-9) | Third | 2½ out |
| Thursday, September 12 |
| » Defeated Indians (71-70), 3-2 | Cleveland Stadium (3-6) | 75-68 | |
| » W: Bill Lee (16-12) L: Jim Perry (15-11) | Second | 2½ out |
| Friday, September 13 |
| » Defeated Brewers (69-77), 8-5 | County Stadium (5-2) | 76-68 | Won 2 |
| » W: Roger Moret (8-9) L: Bill Travers (2-3) | Second | 1½ out |
| Saturday, September 14 |
| » Lost to Brewers (70-77), 3-1 | County Stadium (5-3) | 76-69 | |
| » W: Bill Champion (11-3) L: Reggie Cleveland (10-13) | Third | 2½ out |
| Sunday, September 15 |
| » Lost to Brewers (71-77), 9-5 | County Stadium (5-4) | 76-70 | Lost 2 |
| » W: Clyde Wright (9-19) L: Luis Tiant (20-12) | Third | 3½ out |
| Tuesday, September 17 |
| » Lost to Tigers (68-80), 5-3 | Fenway Park (43-30) | 76-71 | Lost 3 |
| » W: Joe Coleman (13-12) L: Bill Lee (16-13) S: John Hiller (12) | Third | 3½ out |
| Wednesday, September 18 |
| » Defeated Tigers (68-81), 8-5 | Fenway Park (44-30) | 77-71 | |
| » W: Reggie Cleveland (11-13) L: Lerrin LaGrow (8-17) | Third | 2½ out |
| Thursday, September 19 |
| » Lost to Tigers (69-81), 3-1 | Fenway Park (44-31) | 77-72 | |
| » W: Vern Ruhle (1-0) L: Luis Tiant (20-13) | Third | 3 out |
| Friday, September 20 |
| » Lost to Orioles (82-70), 2-1 | Fenway Park (44-32) | 77-73 | Lost 2 |
| » W: Ross Grimsley (18-13) L: Dick Drago (6-10) S: Grant Jackson (12) | Second | 4 out |
| Saturday, September 21 |
| » Defeated Orioles (82-71), 6-5 | Fenway Park (45-32) | 78-73 | |
| » W: Bill Lee (17-13) L: Dave Johnson (2-2) | Third | 4 out |
|