| Monday, January 14 |
| Former Indian Lloyd Brown dies in Opa-Locka, FL at the age of 70. |
| Friday, January 18 |
| Former Indian Pete Appleton dies in Trenton, NJ at the age of 70. |
| Wednesday, January 23 |
| Future Indian Mark Watson is born in Atlanta, GA. |
| Friday, March 22 |
| Future Indian Jason Phillips is born in LaMesa, CA. |
| Thursday, April 4 |
| » Major-league debuts: Jim Sundberg (Rangers) |
| Friday, April 5 |
| » Major-league debuts: Robin Yount (Brewers) |
| Saturday, April 6 |
| » Lost to Yankees (1-0), 6-1 | Shea Stadium (0-1) | 0-1 | |
| » W: Mel Stottlemyre (1-0) L: Gaylord Perry (0-1) | Third | 1 out |
| Sunday, April 7 |
| » Lost to Yankees (2-0), 7-1 | Shea Stadium (0-2) | 0-2 | Lost 2 |
| » W: Pat Dobson (1-0) L: Dick Tidrow (0-1) | Fourth | 2 out |
| Monday, April 8 |
| » Lost to Yankees (3-0), 5-3 | Shea Stadium (0-3) | 0-3 | Lost 3 |
| » W: Doc Medich (1-0) L: Tom Hilgendorf (0-1) S: Tom Buskey (1) | Fourth | 3 out |
| Wednesday, April 10 |
| » Lost to Brewers (2-1), 6-4 | Cleveland Stadium (0-1) | 0-4 | Lost 4 |
| » W: Clyde Wright (1-0) L: Jim Perry (0-1) | Sixth | 4 out |
| Thursday, April 11 |
| » Lost to Brewers (3-1), 7-6 | Cleveland Stadium (0-2) | 0-5 | Lost 5 |
| » W: Jerry Bell (1-0) L: Tom Timmermann (0-1) S: Eduardo Rodriguez (2) | Sixth | 4 out |
| Friday, April 12 |
| » Defeated Yankees (4-2), 9-1 | Cleveland Stadium (1-2) | 1-5 | |
| » W: Gaylord Perry (1-1) L: Pat Dobson (1-1) | Fifth | 3 out |
| Saturday, April 13 |
| » Defeated Yankees (4-3), 8-5 | Cleveland Stadium (2-2) | 2-5 | Won 2 |
| » W: Dick Tidrow (1-1) L: Doc Medich (1-1) | Fifth | 2½ out |
| Sunday, April 14 |
| » Lost to Yankees (5-3), 9-5 | Cleveland Stadium (2-3) | 2-6 | |
| » W: Steve Kline (2-0) L: Bob Johnson (0-1) | Fourth | 2½ out |
| » Defeated Yankees (5-4), 9-6 | Cleveland Stadium (3-3) | 3-6 | |
| » W: Milt Wilcox (1-0) L: Sam McDowell (0-1) | Fourth | 2½ out |
| Tuesday, April 16 |
| » Defeated Brewers (5-3), 3-2 | County Stadium (1-0) | 4-6 | Won 2 |
| » W: Jim Perry (1-1) L: Jim Colborn (0-1) S: Ken Sanders (1) | Fourth | 2 out |
| Wednesday, April 17 |
| » Lost to Brewers (6-3), 5-4 | County Stadium (1-1) | 4-7 | |
| » W: Tom Murphy (1-0) L: Ken Sanders (0-1) | Fourth | 3 out |
| Friday, April 19 |
| » Lost to Red Sox (6-5), 6-3 | Fenway Park (0-1) | 4-8 | Lost 2 |
| » W: Reggie Cleveland (1-1) L: Dick Tidrow (1-2) S: Dick Drago (1) | Sixth | 3½ out |
| Saturday, April 20 |
| » Lost to Red Sox (7-5), 5-4 | Fenway Park (0-2) | 4-9 | Lost 3 |
| » W: Luis Tiant (1-1) L: Bob Johnson (0-2) | Sixth | 4½ out |
| Sunday, April 21 |
| » Lost to Red Sox (8-5), 6-5 | Fenway Park (0-3) | 4-10 | Lost 4 |
| » W: Diego Segui (2-1) L: Cecil Upshaw (0-1) | Sixth | 4½ out |
| Tuesday, April 23 |
| » Defeated Athletics (8-7), 2-1 | Cleveland Stadium (4-3) | 5-10 | |
| » W: Gaylord Perry (2-1) L: Catfish Hunter (3-1) | Sixth | 4 out |
| Wednesday, April 24 |
| » Lost to Athletics (9-7), 9-2 | Cleveland Stadium (4-4) | 5-11 | |
| » W: Ken Holtzman (1-2) L: Dick Tidrow (1-3) | Sixth | 4½ out |
| Friday, April 26 |
| » Defeated Angels (9-9), 4-3 | Cleveland Stadium (5-4) | 6-11 | |
| » W: Tom Timmermann (1-1) L: Nolan Ryan (2-3) S: Milt Wilcox (1) | Sixth | 4½ out |
| Saturday, April 27 |
| » Defeated Angels (9-10), 6-0 | Cleveland Stadium (6-4) | 7-11 | Won 2 |
| » W: Jim Perry (2-1) L: Bill Stoneman (0-1) | Sixth | 3½ out |
| Sunday, April 28 |
| » Defeated Angels (9-11), 10-2 | Cleveland Stadium (7-4) | 8-11 | Won 3 |
| » W: Gaylord Perry (3-1) L: Frank Tanana (2-2) | Sixth | 3½ out |
| Monday, April 29 |
| » Defeated Twins (9-10), 3-2 | Metropolitan Stadium (1-0) | 9-11 | Won 4 |
| » W: Steve Kline (3-2) L: Bill Campbell (2-1) | Fifth | 3 out |
| Tuesday, April 30 |
| » Defeated Twins (9-11), 8-3 | Metropolitan Stadium (2-0) | 10-11 | Won 5 |
| » W: Fritz Peterson (1-0) L: Bert Blyleven (2-3) | Fourth | 2 out |
| Friday, May 3 |
| » Lost to Athletics (11-11), 3-1 | Oakland-Alameda County Stadium (0-1) | 10-12 | |
| » W: Ken Holtzman (2-3) L: Jim Perry (2-2) S: Rollie Fingers (2) | Fifth | 3½ out |
| Saturday, May 4 |
| » Defeated Athletics (11-12), 8-2 | Oakland-Alameda County Stadium (1-1) | 11-12 | |
| » W: Gaylord Perry (4-1) L: Vida Blue (0-4) | Fifth | 2½ out |
| Sunday, May 5 |
| » Lost to Athletics (12-12), 3-0 | Oakland-Alameda County Stadium (1-2) | 11-13 | |
| » W: Catfish Hunter (5-2) L: Steve Kline (3-3) | Third | 2 out |
| » Defeated Athletics (12-13), 9-3 | Oakland-Alameda County Stadium (2-2) | 12-13 | |
| » W: Bob Johnson (1-2) L: Blue Moon Odom (0-2) S: Tom Buskey (2) | Third | 2 out |
| Monday, May 6 |
| » Defeated Angels (15-12), 5-3 | Anaheim Stadium (1-0) | 13-13 | Won 2 |
| » W: Fritz Peterson (2-0) L: Bill Stoneman (1-2) S: Milt Wilcox (2) | Fourth | 2 out |
| Tuesday, May 7 |
| » Defeated Angels (15-13), 5-3 | Anaheim Stadium (2-0) | 14-13 | Won 3 |
| » W: Fred Beene (1-0) L: Frank Tanana (3-3) S: Tom Hilgendorf (1) | Third | 2 out |
| Wednesday, May 8 |
| » Defeated Angels (15-14), 3-2 | Anaheim Stadium (3-0) | 15-13 | Won 4 |
| » W: Tom Hilgendorf (1-1) L: Dave Sells (1-2) S: Tom Buskey (3) | Second | 1 out |
| Friday, May 10 |
| » Lost to Orioles (14-13), 3-1 | Cleveland Stadium (7-5) | 15-14 | |
| » W: Dave McNally (3-2) L: Steve Kline (3-4) | Third | 1½ out |
| Saturday, May 11 |
| » Lost to Orioles (15-13), 12-1 | Cleveland Stadium (7-6) | 15-15 | Lost 2 |
| » W: Mike Cuellar (2-3) L: Fritz Peterson (2-1) | Fourth | 1½ out |
| Monday, May 13 |
| » Defeated Red Sox (15-17), 4-1 | Cleveland Stadium (8-6) | 16-15 | |
| » W: Jim Perry (3-2) L: Luis Tiant (2-5) S: Tom Buskey (4) | Third | 2 out |
| Tuesday, May 14 |
| » Defeated Red Sox (15-18), 6-2 | Cleveland Stadium (9-6) | 17-15 | Won 2 |
| » W: Gaylord Perry (5-1) L: Reggie Cleveland (1-4) | Second | 2 out |
| Wednesday, May 15 |
| » Lost to Red Sox (16-18), 7-4 | Cleveland Stadium (9-7) | 17-16 | |
| » W: Juan Marichal (2-1) L: Steve Kline (3-5) | Third | 2 out |
| Friday, May 17 |
| » Lost to Tigers (17-15), 4-3 | Cleveland Stadium (9-8) | 17-17 | Lost 2 |
| » W: Lerrin LaGrow (3-3) L: Fritz Peterson (2-2) S: John Hiller (6) | Third | 1 out |
| Saturday, May 18 |
| » Lost to Tigers (18-15), 3-2 | Cleveland Stadium (9-9) | 17-18 | Lost 3 |
| » W: Mickey Lolich (3-5) L: Jim Perry (3-3) | Fifth | 2 out |
| Sunday, May 19 |
| » Defeated Tigers (18-16), 2-1 | Cleveland Stadium (10-9) | 18-18 | |
| » W: Gaylord Perry (6-1) L: Joe Coleman (6-2) | Second | 2 out |
| » Defeated Tigers (18-17), 9-4 | Cleveland Stadium (11-9) | 19-18 | Won 2 |
| » W: Bob Johnson (2-2) L: Bill Slayback (1-2) | Second | 2 out |
| Tuesday, May 21 |
| » Lost to Orioles (18-18), 7-1 | Memorial Stadium (0-1) | 19-19 | |
| » W: Mike Cuellar (4-3) L: Steve Kline (3-6) | Fourth | 1½ out |
| Wednesday, May 22 |
| » Lost to Orioles (19-18), 1-0 | Memorial Stadium (0-2) | 19-20 | Lost 2 |
| » W: Ross Grimsley (5-4) L: Tom Buskey (0-2) | Fifth | 1½ out |
| Thursday, May 23 |
| » Defeated Orioles (19-19), 2-0 | Memorial Stadium (1-2) | 20-20 | |
| » W: Gaylord Perry (7-1) L: Jim Palmer (2-5) | Fourth | 1½ out |
| Friday, May 24 |
| » Defeated Tigers (19-21), 3-1 | Tiger Stadium (1-0) | 21-20 | Won 2 |
| » W: Fritz Peterson (3-2) L: Bill Slayback (1-3) | Fourth | 1 out |
| Saturday, May 25 |
| » Lost to Tigers (20-21), 5-4 | Tiger Stadium (1-1) | 21-21 | |
| » W: Luke Walker (1-0) L: Fred Beene (1-1) S: John Hiller (7) | Fourth | 1½ out |
| Sunday, May 26 |
| » Lost to Tigers (21-21), 2-1 | Tiger Stadium (1-2) | 21-22 | Lost 2 |
| » W: Mickey Lolich (5-5) L: Steve Kline (3-7) | Fourth | 2 out |
| Monday, May 27 |
| » Lost to Rangers (22-23), 6-0 | Arlington Stadium (0-1) | 21-23 | Lost 3 |
| » W: Jim Bibby (6-7) L: Jim Perry (3-4) | Fourth | 3 out |
| Tuesday, May 28 |
| » Defeated Rangers (22-24), 8-0 | Arlington Stadium (1-1) | 22-23 | |
| » W: Gaylord Perry (8-1) L: Steve Hargan (3-4) | Fourth | 3 out |
| Wednesday, May 29 |
| » Lost to Rangers (23-24), 3-0 | Arlington Stadium (1-2) | 22-24 | |
| » W: Jackie Brown (3-1) L: Fritz Peterson (3-3) | Fourth | 3½ out |
| Friday, May 31 |
| » Lost to Royals (25-22), 4-2 | Cleveland Stadium (11-10) | 22-25 | Lost 2 |
| » W: Steve Mingori (1-1) L: Steve Kline (3-8) | Fourth | 3½ out |
| Saturday, June 1 |
| » Defeated Royals (25-23), 5-2 | Cleveland Stadium (12-10) | 23-25 | |
| » W: Jim Perry (4-4) L: Bruce Dal Canton (3-3) | Third | 3 out |
| Sunday, June 2 |
| » Defeated Royals (25-24), 5-2 | Cleveland Stadium (13-10) | 24-25 | Won 2 |
| » W: Gaylord Perry (9-1) L: Paul Splittorff (5-5) | Third | 3 out |
| Tuesday, June 4 |
| » Tied Rangers, 5-5 | Cleveland Stadium (13-10) | 24-25 | |
| » Starters: Fergie Jenkins vs Fritz Peterson | Third | 3 out |
| Wednesday, June 5 |
| » Defeated Rangers (25-26), 9-3 | Cleveland Stadium (14-10) | 25-25 | Won 3 |
| » W: Bob Johnson (3-2) L: Jim Bibby (7-8) | Third | 3 out |
| Thursday, June 6 |
| » Lost to Rangers (26-26), 6-2 | Cleveland Stadium (14-11) | 25-26 | |
| » W: Jackie Brown (4-2) L: Jim Perry (4-5) | Third | 3½ out |
| Friday, June 7 |
| » Defeated Royals (26-27), 3-1 | Royals Stadium (1-0) | 26-26 | |
| » W: Gaylord Perry (10-1) L: Paul Splittorff (5-6) | Third | 2½ out |
| Sunday, June 9 |
| » Defeated Royals (26-28), 8-6 | Royals Stadium (2-0) | 27-26 | Won 2 |
| » W: Steve Kline (4-8) L: Steve Busby (7-6) S: Fred Beene (2) | Third | 2 out |
| Tuesday, June 11 |
| » Defeated White Sox (26-26), 6-0 | Comiskey Park I (1-0) | 28-26 | Won 3 |
| » W: Jim Perry (5-5) L: Stan Bahnsen (5-7) | Third | 2½ out |
| Wednesday, June 12 |
| » Defeated White Sox (26-27), 10-1 | Comiskey Park I (2-0) | 29-26 | Won 4 |
| » W: Gaylord Perry (11-1) L: Wilbur Wood (10-7) | Second | 2½ out |
| Friday, June 14 |
| » Lost to Twins (24-31), 8-2 | Cleveland Stadium (14-12) | 29-27 | |
| » W: Joe Decker (7-4) L: Bob Johnson (3-3) | Second | 2½ out |
| Saturday, June 15 |
| » Defeated Twins (24-32), 5-1 | Cleveland Stadium (15-12) | 30-27 | |
| » W: Steve Kline (5-8) L: Bert Blyleven (5-9) S: Fred Beene (3) | Second | 2½ out |
| Sunday, June 16 |
| » Lost to Twins (25-32), 3-0 | Cleveland Stadium (15-13) | 30-28 | |
| » W: Ray Corbin (4-0) L: Jim Perry (5-6) S: Bill Butler (1) | Second | 3 out |
| » Defeated Twins (25-33), 3-1 | Cleveland Stadium (16-13) | 31-28 | |
| » W: Fritz Peterson (4-3) L: Dave Goltz (1-2) | Second | 3 out |
| Monday, June 17 |
| » Defeated White Sox (27-30), 4-3 | Cleveland Stadium (17-13) | 32-28 | Won 2 |
| » W: Gaylord Perry (12-1) L: Cy Acosta (0-3) | Second | 2 out |
| Tuesday, June 18 |
| » Lost to White Sox (28-30), 7-3 | Cleveland Stadium (17-14) | 32-29 | |
| » W: Jim Kaat (6-6) L: Bob Johnson (3-4) | Second | 3 out |
| Wednesday, June 19 |
| » Lost to White Sox (29-30), 15-4 | Cleveland Stadium (17-15) | 32-30 | Lost 2 |
| » W: Stan Bahnsen (6-7) L: Steve Arlin (1-8) S: Skip Pitlock (1) | Third | 4 out |
| Saturday, June 22 |
| » Defeated Red Sox (37-28), 11-0 | Fenway Park (1-3) | 33-30 | |
| » W: Gaylord Perry (13-1) L: Bill Lee (8-6) | Third | 4 out |
| » Lost to Red Sox (38-28), 8-3 | Fenway Park (1-4) | 33-31 | |
| » W: Reggie Cleveland (6-5) L: Jim Perry (5-7) S: Roger Moret (2) | Third | 4 out |
| Sunday, June 23 |
| » Lost to Red Sox (39-28), 8-0 | Fenway Park (1-5) | 33-32 | Lost 2 |
| » W: Rick Wise (3-2) L: Steve Kline (5-9) S: Dick Drago (2) | Third | 5 out |
| Monday, June 24 |
| » Defeated Yankees (35-36), 10-3 | Shea Stadium (1-3) | 34-32 | |
| » W: Fritz Peterson (5-3) L: Doc Medich (8-6) | Fourth | 5 out |
| Wednesday, June 26 |
| » Defeated Yankees (35-37), 3-2 | Shea Stadium (2-3) | 35-32 | Won 2 |
| » W: Steve Arlin (2-8) L: Pat Dobson (6-9) S: Tom Hilgendorf (2) | Third | 4 out |
| Thursday, June 27 |
| » Defeated Red Sox (40-30), 2-1 | Cleveland Stadium (18-15) | 36-32 | Won 3 |
| » W: Jim Perry (6-7) L: Roger Moret (1-2) S: Tom Buskey (5) | Second | 3 out |
| Friday, June 28 |
| » Defeated Red Sox (40-31), 2-1 | Cleveland Stadium (19-15) | 37-32 | Won 4 |
| » W: Gaylord Perry (14-1) L: Dick Drago (5-3) | Second | 2 out |
| Saturday, June 29 |
| » Lost to Red Sox (41-31), 12-2 | Cleveland Stadium (19-16) | 37-33 | |
| » W: Luis Tiant (11-6) L: Fritz Peterson (5-4) | Second | 3 out |
| Sunday, June 30 |
| » Defeated Red Sox (41-32), 9-2 | Cleveland Stadium (20-16) | 38-33 | |
| » W: Steve Arlin (3-8) L: Rick Wise (3-3) | Second | 2 out |
| Monday, July 1 |
| » Defeated Brewers (36-36), 3-1 | Cleveland Stadium (21-16) | 39-33 | Won 2 |
| » W: Fred Beene (2-1) L: Clyde Wright (7-10) | Second | 1½ out |
| » Defeated Brewers (36-37), 9-3 | Cleveland Stadium (22-16) | 40-33 | Won 3 |
| » W: Fritz Peterson (6-4) L: Eduardo Rodriguez (5-2) | Second | 1½ out |
| Tuesday, July 2 |
| » Defeated Brewers (36-38), 5-3 | Cleveland Stadium (23-16) | 41-33 | Won 4 |
| » W: Jim Perry (7-7) L: Kevin Kobel (3-8) S: Tom Hilgendorf (3) | Second | 1½ out |
| Wednesday, July 3 |
| » Defeated Brewers (36-39), 4-2 | County Stadium (2-1) | 42-33 | Won 5 |
| » W: Gaylord Perry (15-1) L: Jim Colborn (4-5) | First | -- |
| Thursday, July 4 |
| » Lost to Brewers (37-39), 15-3 | County Stadium (2-2) | 42-34 | |
| » W: Ed Sprague (6-1) L: Steve Arlin (3-9) | First | -- |
| » Major-league debuts: Bruce Ellingsen (Indians) |
| Friday, July 5 |
| » Defeated Angels (32-51), 7-2 | Anaheim Stadium (4-0) | 43-34 | |
| » W: Fritz Peterson (7-4) L: Nolan Ryan (10-8) | First | -- |
| Former Indian Duster Mails dies in San Francisco, CA at the age of 80. |
| Saturday, July 6 |
| » Defeated Angels (32-52), 1-0 | Anaheim Stadium (5-0) | 44-34 | Won 2 |
| » W: Dick Bosman (1-0) L: Ed Figueroa (0-1) S: Tom Buskey (6) | First | -- |
| Sunday, July 7 |
| » Defeated Angels (32-53), 6-2 | Anaheim Stadium (6-0) | 45-34 | Won 3 |
| » W: Jim Perry (8-7) L: Frank Tanana (4-13) S: Milt Wilcox (3) | First | -- |
| Monday, July 8 |
| » Lost to Athletics (47-37), 4-3 | Oakland-Alameda County Stadium (2-3) | 45-35 | |
| » W: Vida Blue (9-8) L: Gaylord Perry (15-2) | First | -- |
| Tuesday, July 9 |
| » Lost to Athletics (48-37), 7-0 | Oakland-Alameda County Stadium (2-4) | 45-36 | Lost 2 |
| » W: Catfish Hunter (12-8) L: Steve Arlin (3-10) | First | -- |
| Thursday, July 11 |
| » Lost to Twins (40-47), 5-2 | Metropolitan Stadium (2-1) | 45-37 | Lost 3 |
| » W: Joe Decker (9-8) L: Fred Beene (2-2) | Second | 1½ out |
| Friday, July 12 |
| » Defeated Twins (40-48), 9-5 | Metropolitan Stadium (3-1) | 46-37 | |
| » W: Jim Perry (9-7) L: Ray Corbin (5-3) | First | -- |
| Saturday, July 13 |
| » Lost to Twins (41-48), 2-1 | Metropolitan Stadium (3-2) | 46-38 | |
| » W: Bill Campbell (4-5) L: Tom Hilgendorf (1-2) | First | -- |
| Sunday, July 14 |
| » Lost to Twins (42-48), 6-5 | Metropolitan Stadium (3-3) | 46-39 | Lost 2 |
| » W: Tom Burgmeier (4-2) L: Milt Wilcox (1-1) | Second | 1½ out |
| Monday, July 15 |
| » Lost to Angels (35-57), 4-2 | Cleveland Stadium (23-17) | 46-40 | Lost 3 |
| » W: Nolan Ryan (11-9) L: Steve Arlin (3-11) S: Dave Sells (2) | Second | 1½ out |
| Tuesday, July 16 |
| » Lost to Angels (36-57), 11-2 | Cleveland Stadium (23-18) | 46-41 | Lost 4 |
| » W: Frank Tanana (5-13) L: Fritz Peterson (7-5) | Second | 1½ out |
| Wednesday, July 17 |
| » Lost to Angels (37-57), 7-5 | Cleveland Stadium (23-19) | 46-42 | Lost 5 |
| » W: Dave Sells (2-3) L: Tom Buskey (0-3) | Second | 1½ out |
| Thursday, July 18 |
| » Lost to Athletics (54-39), 3-2 | Cleveland Stadium (23-20) | 46-43 | Lost 6 |
| » W: Catfish Hunter (14-8) L: Gaylord Perry (15-3) | Third | 1½ out |
| Friday, July 19 |
| » Defeated Athletics (54-40), 4-0 | Cleveland Stadium (24-20) | 47-43 | |
| » W: Dick Bosman (2-0) L: Dave Hamilton (6-3) | Third | 1½ out |
| Saturday, July 20 |
| » Defeated Athletics (54-41), 10-9 | Cleveland Stadium (25-20) | 48-43 | Won 2 |
| » W: Tom Hilgendorf (2-2) L: Rollie Fingers (7-3) | Third | 1½ out |
| Sunday, July 21 |
| » Lost to Athletics (55-41), 6-3 | Cleveland Stadium (25-21) | 48-44 | |
| » W: Vida Blue (11-9) L: Jim Perry (9-8) S: Paul Lindblad (5) | Second | 1½ out |
| Thursday, July 25 |
| » Defeated Orioles (49-46), 8-7 | Cleveland Stadium (26-21) | 49-44 | |
| » W: Dick Bosman (3-0) L: Dave McNally (8-8) S: Tom Buskey (7) | First | -- |
| » Defeated Orioles (49-47), 5-4 | Cleveland Stadium (27-21) | 50-44 | Won 2 |
| » W: Tom Hilgendorf (3-2) L: Bob Reynolds (4-4) | First | -- |
| Friday, July 26 |
| » Lost to Orioles (50-47), 9-5 | Cleveland Stadium (27-22) | 50-45 | |
| » W: Dave Johnson (1-1) L: Gaylord Perry (15-4) | Second | 1 out |
| Saturday, July 27 |
| » Defeated Tigers (46-52), 3-2 | Cleveland Stadium (28-22) | 51-45 | |
| » W: Jim Perry (10-8) L: Lerrin LaGrow (7-10) S: Tom Buskey (8) | Second | 1 out |
| Sunday, July 28 |
| » Lost to Tigers (47-52), 6-3 | Cleveland Stadium (28-23) | 51-46 | |
| » W: John Hiller (12-7) L: Fred Beene (2-3) | Second | 1 out |
| Monday, July 29 |
| » Lost to Tigers (48-52), 8-2 | Cleveland Stadium (28-24) | 51-47 | Lost 2 |
| » W: Mickey Lolich (11-13) L: Fritz Peterson (7-6) | Second | 2 out |
| Tuesday, July 30 |
| » Defeated Orioles (51-50), 8-6 | Memorial Stadium (2-2) | 52-47 | |
| » W: Dick Bosman (4-0) L: Mike Cuellar (13-7) | Second | 1 out |
| Wednesday, July 31 |
| » Lost to Orioles (52-50), 7-4 | Memorial Stadium (2-3) | 52-48 | |
| » W: Dave McNally (9-8) L: Gaylord Perry (15-5) | Second | 2 out |
| Thursday, August 1 |
| » Defeated Yankees (51-53), 9-2 | Cleveland Stadium (29-24) | 53-48 | |
| » W: Jim Perry (11-8) L: Dave Pagan (1-3) | Second | 2 out |
| Friday, August 2 |
| » Defeated Yankees (51-54), 8-2 | Cleveland Stadium (30-24) | 54-48 | Won 2 |
| » W: Fritz Peterson (8-6) L: Sam McDowell (1-5) | Second | 2 out |
| Saturday, August 3 |
| » Defeated Brewers (51-55), 7-6 | County Stadium (3-2) | 55-48 | Won 3 |
| » W: Bruce Ellingsen (1-0) L: Jim Colborn (6-9) S: Tom Buskey (9) | Second | 1 out |
| Sunday, August 4 |
| » Defeated Brewers (51-56), 4-3 | County Stadium (4-2) | 56-48 | Won 4 |
| » W: Dick Bosman (5-0) L: Bill Champion (5-2) S: Tom Buskey (10) | Second | 1½ out |
| » Lost to Brewers (52-56), 8-3 | County Stadium (4-3) | 56-49 | |
| » W: Kevin Kobel (5-8) L: Gaylord Perry (15-6) | Second | 1½ out |
| Tuesday, August 6 |
| » Defeated Tigers (52-58), 9-7 | Tiger Stadium (2-2) | 57-49 | |
| » W: Milt Wilcox (2-1) L: Jim Ray (0-3) S: Tom Buskey (11) | Second | 1½ out |
| Wednesday, August 7 |
| » Lost to Tigers (53-58), 3-2 | Tiger Stadium (2-3) | 57-50 | |
| » W: Mickey Lolich (12-14) L: Fred Beene (2-4) | Second | 2½ out |
| Thursday, August 8 |
| » Lost to Tigers (54-58), 4-3 | Tiger Stadium (2-4) | 57-51 | Lost 2 |
| » W: Jim Ray (1-3) L: Tom Buskey (0-4) | Second | 2½ out |
| Friday, August 9 |
| » Lost to White Sox (57-55), 5-3 | Cleveland Stadium (30-25) | 57-52 | Lost 3 |
| » W: Stan Bahnsen (10-13) L: Gaylord Perry (15-7) S: Terry Forster (17) | Second | 3½ out |
| Saturday, August 10 |
| » Lost to White Sox (58-55), 5-1 | Cleveland Stadium (30-26) | 57-53 | Lost 4 |
| » W: Wilbur Wood (18-13) L: Dick Bosman (5-1) | Second | 3½ out |
| Sunday, August 11 |
| » Defeated White Sox (58-56), 3-2 | Cleveland Stadium (31-26) | 58-53 | |
| » W: Jim Perry (12-8) L: Jim Kaat (13-9) S: Tom Buskey (12) | Second | 3½ out |
| Wednesday, August 14 |
| » Lost to Twins (58-60), 1-0 | Cleveland Stadium (31-27) | 58-54 | |
| » W: Joe Decker (12-10) L: Fritz Peterson (8-7) S: Bill Campbell (17) | Second | 3½ out |
| Thursday, August 15 |
| » Defeated Twins (58-61), 4-2 | Cleveland Stadium (32-27) | 59-54 | |
| » W: Gaylord Perry (16-7) L: Bert Blyleven (11-14) S: Tom Buskey (13) | Second | 3 out |
| Friday, August 16 |
| » Lost to Rangers (60-60), 7-3 | Cleveland Stadium (32-28) | 59-55 | |
| » W: Jim Bibby (17-14) L: Dick Bosman (5-2) | Second | 4 out |
| Saturday, August 17 |
| » Defeated Rangers (60-61), 4-0 | Cleveland Stadium (33-28) | 60-55 | |
| » W: Jim Perry (13-8) L: Steve Hargan (9-8) | Second | 3 out |
| Sunday, August 18 |
| » Lost to Rangers (61-61), 1-0 | Cleveland Stadium (33-29) | 60-56 | |
| » W: Fergie Jenkins (17-11) L: Fritz Peterson (8-8) | Second | 4 out |
| Tuesday, August 20 |
| » Lost to Royals (64-56), 2-0 | Cleveland Stadium (33-30) | 60-57 | Lost 2 |
| » W: Al Fitzmorris (9-3) L: Gaylord Perry (16-8) S: Lindy McDaniel (1) | Second | 5½ out |
| Wednesday, August 21 |
| » Defeated Royals (64-57), 7-6 | Cleveland Stadium (34-30) | 61-57 | |
| » W: Tom Buskey (1-4) L: Steve Mingori (2-3) | Second | 5½ out |
| Thursday, August 22 |
| » Lost to Royals (65-57), 3-1 | Cleveland Stadium (34-31) | 61-58 | |
| » W: Paul Splittorff (13-12) L: Jim Perry (13-9) | Second | 6 out |
| Friday, August 23 |
| » Lost to White Sox (61-64), 2-1 | Comiskey Park I (2-1) | 61-59 | Lost 2 |
| » W: Jim Kaat (14-11) L: Fritz Peterson (8-9) | Third | 7 out |
| Saturday, August 24 |
| » Lost to White Sox (62-64), 3-0 | Comiskey Park I (2-2) | 61-60 | Lost 3 |
| » W: Bart Johnson (5-2) L: Gaylord Perry (16-9) | Fourth | 7 out |
| Sunday, August 25 |
| » Lost to White Sox (63-64), 8-5 | Comiskey Park I (2-3) | 61-61 | Lost 4 |
| » W: Wilbur Wood (19-15) L: Dick Bosman (5-3) | Fourth | 7½ out |
| » Lost to White Sox (64-64), 8-5 | Comiskey Park I (2-4) | 61-62 | Lost 5 |
| » W: Rich Gossage (3-4) L: Steve Arlin (3-12) S: Terry Forster (18) | Fourth | 7½ out |
| Monday, August 26 |
| » Defeated Royals (68-59), 4-1 | Royals Stadium (3-0) | 62-62 | |
| » W: Jim Perry (14-9) L: Paul Splittorff (13-13) | Third | 7 out |
| Tuesday, August 27 |
| » Defeated Royals (68-60), 12-8 | Royals Stadium (4-0) | 63-62 | Won 2 |
| » W: Tom Hilgendorf (4-2) L: Steve Busby (19-11) S: Tom Buskey (14) | Third | 7½ out |
| » Lost to Royals (69-60), 13-2 | Royals Stadium (4-1) | 63-63 | |
| » W: Nelson Briles (4-5) L: Milt Wilcox (2-2) | Third | 7½ out |
| Wednesday, August 28 |
| » Defeated Royals (69-61), 7-1 | Royals Stadium (5-1) | 64-63 | |
| » W: Gaylord Perry (17-9) L: Al Fitzmorris (10-4) | Third | 6½ out |
| Friday, August 30 |
| » Defeated Rangers (67-65), 7-3 | Arlington Stadium (2-2) | 65-63 | Won 2 |
| » W: Fred Beene (3-4) L: Pete Broberg (0-4) | Third | 6 out |
| Saturday, August 31 |
| » Lost to Rangers (68-65), 2-0 | Arlington Stadium (2-3) | 65-64 | |
| » W: Fergie Jenkins (20-11) L: Jim Perry (14-10) | Fourth | 6 out |
| Sunday, September 1 |
| » Lost to Rangers (69-65), 10-3 | Arlington Stadium (2-4) | 65-65 | Lost 2 |
| » W: Jackie Brown (11-10) L: Fritz Peterson (8-10) | Fourth | 6 out |
| Tuesday, September 3 |
| » Defeated Tigers (62-72), 5-1 | Tiger Stadium (3-4) | 66-65 | |
| » W: Gaylord Perry (18-9) L: Fred Holdsworth (0-3) | Fourth | 5 out |
| » Lost to Tigers (63-72), 5-4 | Tiger Stadium (3-5) | 66-66 | |
| » W: John Hiller (16-9) L: Tom Buskey (1-5) | Fourth | 5 out |
| » Major-league debuts: Leon Roberts (Tigers) |
| Wednesday, September 4 |
| » Defeated Tigers (63-73), 5-4 | Tiger Stadium (4-5) | 67-66 | |
| » W: Tom Buskey (2-5) L: John Hiller (16-10) | Third | 4 out |
| Friday, September 6 |
| » Lost to Orioles (71-65), 2-0 | Cleveland Stadium (34-32) | 67-67 | |
| » W: Dave McNally (14-10) L: Fritz Peterson (8-11) | Third | 5½ out |
| » Lost to Orioles (72-65), 1-0 | Cleveland Stadium (34-33) | 67-68 | Lost 2 |
| » W: Mike Cuellar (18-10) L: Jim Kern (0-1) | Third | 5½ out |
| » Major-league debuts: Jim Kern (Indians) |
| Saturday, September 7 |
| » Lost to Orioles (73-65), 3-2 | Cleveland Stadium (34-34) | 67-69 | Lost 3 |
| » W: Ross Grimsley (17-12) L: Gaylord Perry (18-10) S: Bob Reynolds (6) | Third | 6 out |
| Sunday, September 8 |
| » Defeated Orioles (73-66), 7-4 | Cleveland Stadium (35-34) | 68-69 | |
| » W: Jim Perry (15-10) L: Jim Palmer (6-11) S: Tom Buskey (15) | Third | 5 out |
| Monday, September 9 |
| » Defeated Tigers (65-76), 7-1 | Cleveland Stadium (36-34) | 69-69 | Won 2 |
| » W: Dick Bosman (6-3) L: Lerrin LaGrow (8-16) | Third | 5 out |
| » Major-league debuts: Duane Kuiper (Indians) Vern Ruhle (Tigers) |
| Tuesday, September 10 |
| » Defeated Tigers (65-77), 12-6 | Cleveland Stadium (37-34) | 70-69 | Won 3 |
| » W: Fritz Peterson (9-11) L: Mickey Lolich (16-18) | Third | 5 out |
| Wednesday, September 11 |
| » Defeated Red Sox (74-68), 3-1 | Cleveland Stadium (38-34) | 71-69 | Won 4 |
| » W: Gaylord Perry (19-10) L: Dick Drago (6-9) | Fourth | 4½ out |
| Thursday, September 12 |
| » Lost to Red Sox (75-68), 3-2 | Cleveland Stadium (38-35) | 71-70 | |
| » W: Bill Lee (16-12) L: Jim Perry (15-11) | Fourth | 5½ out |
| Friday, September 13 |
| » Lost to Orioles (76-69), 3-2 | Memorial Stadium (2-4) | 71-71 | Lost 2 |
| » W: Mike Cuellar (19-10) L: Dick Bosman (6-4) | Fourth | 6 out |
| » Lost to Orioles (77-69), 8-6 | Memorial Stadium (2-5) | 71-72 | Lost 3 |
| » W: Bob Reynolds (6-5) L: Tom Buskey (2-6) S: Grant Jackson (11) | Fourth | 6 out |
| » Major-league debuts: Tim Nordbrook (Orioles) |
| Saturday, September 14 |
| » Lost to Orioles (78-69), 7-1 | Memorial Stadium (2-6) | 71-73 | Lost 4 |
| » W: Dave McNally (15-10) L: Fritz Peterson (9-12) | Fourth | 7 out |
| Sunday, September 15 |
| » Defeated Orioles (78-70), 1-0 | Memorial Stadium (3-6) | 72-73 | |
| » W: Gaylord Perry (20-10) L: Ross Grimsley (17-13) | Fourth | 7 out |
| Monday, September 16 |
| » Major-league debuts: Gary Carter and Jerry White (Expos) |
| Tuesday, September 17 |
| » Lost to Brewers (72-77), 3-2 | County Stadium (4-4) | 72-74 | |
| » W: Jim Colborn (9-12) L: Jim Perry (15-12) S: Tom Murphy (20) | Fourth | 7 out |
| Wednesday, September 18 |
| » Defeated Brewers (72-78), 6-3 | County Stadium (5-4) | 73-74 | |
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