| Monday, January 8 |
| Future White Sox Mike Cameron is born in LaGrange, GA. |
| Thursday, April 5 |
| » Major-league debuts: Gene Locklear (Reds) |
| Friday, April 6 |
| Former White Sox Ernie Smith dies in Brooklyn, NY at the age of 74. |
| Saturday, April 7 |
| » Defeated Rangers (0-1), 3-1 | Arlington Stadium (1-0) | 1-0 | |
| » Starters: Wilbur Wood vs Dick Bosman | Second | ½ out |
| » Major-league debuts: Steve Foucault (Rangers) |
| Wednesday, April 11 |
| » Lost to Athletics (1-3), 12-2 | Comiskey Park I (0-1) | 1-1 | |
| » Starters: Vida Blue vs Wilbur Wood | Third | 1½ out |
| Thursday, April 12 |
| » Defeated Athletics (1-4), 6-3 | Comiskey Park I (1-1) | 2-1 | |
| » Starters: Darold Knowles vs Stan Bahnsen | Second | 1½ out |
| Friday, April 13 |
| » Lost to Royals (5-2), 12-5 | Comiskey Park I (1-2) | 2-2 | |
| » Starters: Dick Drago vs Eddie Fisher | Third | 1½ out |
| Saturday, April 14 |
| » Lost to Royals (6-2), 3-0 | Comiskey Park I (1-3) | 2-3 | Lost 2 |
| » Starters: Paul Splittorff vs Wilbur Wood | Fourth | 2½ out |
| Sunday, April 15 |
| » Lost to Royals (7-2), 12-5 | Comiskey Park I (1-4) | 2-4 | Lost 3 |
| » Starters: Steve Busby vs Stan Bahnsen | Fifth | 3½ out |
| Tuesday, April 17 |
| » Defeated Rangers (2-4), 10-5 | Comiskey Park I (2-4) | 3-4 | |
| » Starters: Dick Bosman vs Eddie Fisher | Third | 3½ out |
| Wednesday, April 18 |
| » Defeated Rangers (2-5), 6-5 | Comiskey Park I (3-4) | 4-4 | Won 2 |
| » Starters: Mike Paul vs Wilbur Wood | Third | 2½ out |
| Friday, April 20 |
| » Defeated Royals (9-4), 16-2 | Royals Stadium (1-0) | 5-4 | Won 3 |
| » Starters: Stan Bahnsen vs Steve Busby | Third | 2 out |
| Sunday, April 22 |
| » Defeated Royals (9-5), 8-4 | Royals Stadium (2-0) | 6-4 | Won 4 |
| » Starters: Wilbur Wood vs Dick Drago | Third | 2 out |
| » Lost to Royals (10-5), 6-1 | Royals Stadium (2-1) | 6-5 | |
| » Starters: Rich Gossage vs Ken Wright | Third | 2 out |
| Tuesday, April 24 |
| » Defeated Yankees (6-9), 8-4 | Yankee Stadium (1-0) | 7-5 | |
| » Starters: Stan Bahnsen vs Fritz Peterson | Third | 1½ out |
| Wednesday, April 25 |
| » Defeated Yankees (6-10), 3-0 | Yankee Stadium (2-0) | 8-5 | Won 2 |
| » Starters: Wilbur Wood vs Mel Stottlemyre | Third | 2 out |
| Saturday, April 28 |
| » Defeated Red Sox (7-9), 2-1 | Fenway Park (1-0) | 9-5 | Won 3 |
| » Starters: Stan Bahnsen vs Luis Tiant | Second | 3 out |
| Sunday, April 29 |
| » Defeated Red Sox (7-10), 5-0 | Fenway Park (2-0) | 10-5 | Won 4 |
| » Starters: Wilbur Wood vs Marty Pattin | First | -- |
| Tuesday, May 1 |
| » Defeated Orioles (10-10), 6-5 | Comiskey Park I (4-4) | 11-5 | Won 5 |
| » Starters: Mike Cuellar vs Eddie Fisher | First | -- |
| Wednesday, May 2 |
| » Defeated Orioles (10-11), 4-0 | Comiskey Park I (5-4) | 12-5 | Won 6 |
| » Starters: Jim Palmer vs Wilbur Wood | First | -- |
| Friday, May 4 |
| » Defeated Yankees (10-12), 5-0 | Comiskey Park I (6-4) | 13-5 | Won 7 |
| » Starters: Mel Stottlemyre vs Stan Bahnsen | First | -- |
| Saturday, May 5 |
| » Defeated Yankees (10-13), 4-0 | Comiskey Park I (7-4) | 14-5 | Won 8 |
| » Starters: Fritz Peterson vs Eddie Fisher | First | -- |
| Sunday, May 6 |
| » Defeated Yankees (10-14), 11-2 | Comiskey Park I (8-4) | 15-5 | Won 9 |
| » Starters: Steve Kline vs Wilbur Wood | First | -- |
| Monday, May 7 |
| » Lost to Red Sox (10-13), 4-1 | Comiskey Park I (8-5) | 15-6 | |
| » Starters: John Curtis vs Stan Bahnsen | First | -- |
| Tuesday, May 8 |
| » Defeated Red Sox (10-14), 1-0 | Comiskey Park I (9-5) | 16-6 | |
| » Starters: Marty Pattin vs Eddie Fisher | First | -- |
| Thursday, May 10 |
| » Defeated Angels (13-12), 4-3 | Anaheim Stadium (1-0) | 17-6 | Won 2 |
| » Starters: Wilbur Wood vs Bill Singer | First | -- |
| Friday, May 11 |
| » Defeated Angels (13-13), 7-4 | Anaheim Stadium (2-0) | 18-6 | Won 3 |
| » Starters: Stan Bahnsen vs Nolan Ryan | First | -- |
| Saturday, May 12 |
| » Lost to Angels (14-13), 6-5 | Anaheim Stadium (2-1) | 18-7 | |
| » Starters: Eddie Fisher vs Clyde Wright | First | -- |
| Sunday, May 13 |
| » Lost to Angels (15-13), 3-0 | Anaheim Stadium (2-2) | 18-8 | Lost 2 |
| » Starters: Rich Gossage vs Rudy May | First | -- |
| Monday, May 14 |
| » Lost to Athletics (18-15), 5-1 | Oakland-Alameda County Stadium (0-1) | 18-9 | Lost 3 |
| » Starters: Wilbur Wood vs Ken Holtzman | First | -- |
| Tuesday, May 15 |
| » Defeated Athletics (18-16), 6-5 | Oakland-Alameda County Stadium (1-1) | 19-9 | |
| » Starters: Stan Bahnsen vs Vida Blue | First | -- |
| Wednesday, May 16 |
| » Lost to Twins (15-15), 8-6 | Metropolitan Stadium (0-1) | 19-10 | |
| » Starters: Eddie Fisher vs Bill Hands | First | -- |
| Thursday, May 17 |
| » Defeated Twins (15-16), 5-4 | Metropolitan Stadium (1-1) | 20-10 | |
| » Starters: Wilbur Wood vs Dick Woodson | First | -- |
| Friday, May 18 |
| » Lost to Twins (16-16), 3-0 | Comiskey Park I (9-6) | 20-11 | |
| » Starters: Jim Kaat vs Rich Gossage | First | -- |
| Saturday, May 19 |
| » Lost to Twins (17-16), 8-3 | Comiskey Park I (9-7) | 20-12 | Lost 2 |
| » Starters: Bert Blyleven vs Stan Bahnsen | First | -- |
| Former White Sox Jim Moore dies in Seattle, WA at the age of 70. |
| Sunday, May 20 |
| » Defeated Twins (17-17), 9-3 | Comiskey Park I (10-7) | 21-12 | |
| » Starters: Bill Hands vs Wilbur Wood | First | -- |
| » Lost to Twins (18-17), 3-0 | Comiskey Park I (10-8) | 21-13 | |
| » Starters: Ray Corbin vs Eddie Fisher | First | -- |
| Tuesday, May 22 |
| » Defeated Angels (21-15), 6-2 | Comiskey Park I (11-8) | 22-13 | |
| » Starters: Rudy May vs Stan Bahnsen | First | -- |
| Wednesday, May 23 |
| » Defeated Angels (21-16), 5-3 | Comiskey Park I (12-8) | 23-13 | Won 2 |
| » Starters: Bill Singer vs Eddie Fisher | First | -- |
| Thursday, May 24 |
| » Defeated Angels (21-17), 4-1 | Comiskey Park I (13-8) | 24-13 | Won 3 |
| » Starters: Nolan Ryan vs Wilbur Wood | First | -- |
| Friday, May 25 |
| » Lost to Indians (19-23), 8-3 | Comiskey Park I (13-9) | 24-14 | |
| » Starters: Dick Bosman vs Rich Gossage | First | -- |
| Saturday, May 26 |
| » Major-league debuts: Bill Sharp (White Sox) |
| Monday, May 28 |
| » Defeated Indians (19-24), 4-0 | Comiskey Park I (14-9) | 25-14 | |
| » Starters: Dick Tidrow vs Wilbur Wood | First | -- |
| » Defeated Indians (19-25), 6-3 | Comiskey Park I (15-9) | 26-14 | Won 2 |
| » Starters: Gaylord Perry vs Stan Bahnsen | First | -- |
| Wednesday, May 30 |
| » Lost to Tigers (25-20), 8-3 | Comiskey Park I (15-10) | 26-15 | |
| » Starters: Mickey Lolich vs Stan Bahnsen | First | -- |
| Thursday, May 31 |
| » Defeated Tigers (25-21), 10-2 | Comiskey Park I (16-10) | 27-15 | |
| » Starters: Jim Perry vs Eddie Fisher | First | -- |
| » Major-league debuts: Brian Downing (White Sox) |
| Friday, June 1 |
| » Lost to Brewers (20-26), 5-3 | County Stadium (0-1) | 27-16 | |
| » Starters: Wilbur Wood vs Chris Short | First | -- |
| » Major-league debuts: Bucky Dent (White Sox) |
| Saturday, June 2 |
| » Lost to Brewers (21-26), 3-2 | County Stadium (0-2) | 27-17 | Lost 2 |
| » Starters: Steve Stone vs Jim Slaton | First | -- |
| Sunday, June 3 |
| » Lost to Brewers (22-26), 7-1 | County Stadium (0-3) | 27-18 | Lost 3 |
| » Starters: Stan Bahnsen vs Jerry Bell | First | -- |
| Future White Sox Robert Machado is born in Caracas, Venezuela. |
| Monday, June 4 |
| Future White Sox David Lundquist is born in Beverly, MA. |
| Tuesday, June 5 |
| » Lost to Orioles (23-22), 7-4 | Memorial Stadium (0-1) | 27-19 | Lost 4 |
| » Starters: Wilbur Wood vs Mike Cuellar | First | -- |
| Wednesday, June 6 |
| » Lost to Orioles (24-22), 14-4 | Memorial Stadium (0-2) | 27-20 | Lost 5 |
| » Starters: Eddie Fisher vs Doyle Alexander | First | -- |
| Thursday, June 7 |
| » Defeated Orioles (24-23), 3-2 | Memorial Stadium (1-2) | 28-20 | |
| » Starters: Steve Stone vs Jim Palmer | First | -- |
| Friday, June 8 |
| » Defeated Indians (20-33), 5-2 | Cleveland Stadium (1-0) | 29-20 | Won 2 |
| » Starters: Wilbur Wood vs Milt Wilcox | First | -- |
| Saturday, June 9 |
| » Defeated Indians (20-34), 6-3 | Cleveland Stadium (2-0) | 30-20 | Won 3 |
| » Starters: Eddie Fisher vs Gaylord Perry | First | -- |
| Sunday, June 10 |
| » Defeated Indians (20-35), 5-3 | Cleveland Stadium (3-0) | 31-20 | Won 4 |
| » Starters: Steve Stone vs Dick Tidrow | First | -- |
| » Lost to Indians (21-35), 6-5 | Cleveland Stadium (3-1) | 31-21 | |
| » Starters: Eddie Fisher vs Dick Bosman | First | -- |
| Tuesday, June 12 |
| » Lost to Tigers (30-26), 6-5 | Tiger Stadium (0-1) | 31-22 | Lost 2 |
| » Starters: Wilbur Wood vs Woodie Fryman | First | -- |
| Wednesday, June 13 |
| » Defeated Tigers (30-27), 10-2 | Tiger Stadium (1-1) | 32-22 | |
| » Starters: Stan Bahnsen vs Mickey Lolich | First | -- |
| Friday, June 15 |
| » Lost to Brewers (31-27), 1-0 | Comiskey Park I (16-11) | 32-23 | |
| » Starters: Jim Slaton vs Wilbur Wood | First | -- |
| Saturday, June 16 |
| » Lost to Brewers (32-27), 4-1 | Comiskey Park I (16-12) | 32-24 | Lost 2 |
| » Starters: Bill Parsons vs Steve Stone | First | -- |
| Sunday, June 17 |
| » Lost to Brewers (33-27), 15-5 | Comiskey Park I (16-13) | 32-25 | Lost 3 |
| » Starters: Jerry Bell vs Stan Bahnsen | First | -- |
| Monday, June 18 |
| » Lost to Angels (32-29), 9-2 | Comiskey Park I (16-14) | 32-26 | Lost 4 |
| » Starters: Rich Hand vs Eddie Fisher | First | -- |
| Tuesday, June 19 |
| » Lost to Angels (33-29), 3-1 | Comiskey Park I (16-15) | 32-27 | Lost 5 |
| » Starters: Bill Singer vs Wilbur Wood | Second | ½ out |
| Wednesday, June 20 |
| » Defeated Angels (33-30), 8-3 | Comiskey Park I (17-15) | 33-27 | |
| » Starters: Nolan Ryan vs Steve Stone | First | -- |
| Thursday, June 21 |
| » Defeated Athletics (35-32), 2-0 | Comiskey Park I (18-15) | 34-27 | Won 2 |
| » Starters: Ken Holtzman vs Stan Bahnsen | First | -- |
| Friday, June 22 |
| » Lost to Athletics (36-32), 7-1 | Comiskey Park I (18-16) | 34-28 | |
| » Starters: Dave Hamilton vs Wilbur Wood | First | -- |
| Saturday, June 23 |
| » Lost to Athletics (37-32), 14-3 | Comiskey Park I (18-17) | 34-29 | Lost 2 |
| » Starters: Catfish Hunter vs Eddie Fisher | First | -- |
| Sunday, June 24 |
| » Lost to Athletics (38-32), 7-0 | Comiskey Park I (18-18) | 34-30 | Lost 3 |
| » Starters: Vida Blue vs Steve Stone | Second | 4 out |
| » Defeated Athletics (38-33), 11-1 | Comiskey Park I (19-18) | 35-30 | |
| » Starters: Blue Moon Odom vs Bart Johnson | Second | 4 out |
| Monday, June 25 |
| » Defeated Twins (35-32), 3-2 | Comiskey Park I (20-18) | 36-30 | Won 2 |
| » Starters: Bert Blyleven vs Stan Bahnsen | First | -- |
| Tuesday, June 26 |
| » Lost to Twins (36-32), 4-0 | Comiskey Park I (20-19) | 36-31 | |
| » Starters: Joe Decker vs Wilbur Wood | Second | 1½ out |
| Wednesday, June 27 |
| » Lost to Angels (39-32), 3-1 | Anaheim Stadium (2-3) | 36-32 | Lost 2 |
| » Starters: Bart Johnson vs Bill Singer | Third | 1½ out |
| Thursday, June 28 |
| » Defeated Angels (39-33), 2-0 | Anaheim Stadium (3-3) | 37-32 | |
| » Starters: Steve Stone vs Clyde Wright | Third | 3 out |
| Friday, June 29 |
| » Defeated Athletics (41-35), 4-3 | Oakland-Alameda County Stadium (2-1) | 38-32 | Won 2 |
| » Starters: Stan Bahnsen vs Ken Holtzman | First | -- |
| Saturday, June 30 |
| » Lost to Athletics (42-35), 3-2 | Oakland-Alameda County Stadium (2-2) | 38-33 | |
| » Starters: Wilbur Wood vs Dave Hamilton | Third | 3 out |
| Sunday, July 1 |
| » Lost to Athletics (43-35), 6-4 | Oakland-Alameda County Stadium (2-3) | 38-34 | Lost 2 |
| » Starters: Eddie Fisher vs Catfish Hunter | Third | 3 out |
| » Lost to Athletics (44-35), 3-0 | Oakland-Alameda County Stadium (2-4) | 38-35 | Lost 3 |
| » Starters: Bart Johnson vs Blue Moon Odom | Third | 3 out |
| Monday, July 2 |
| » Defeated Rangers (26-47), 5-4 | Arlington Stadium (2-0) | 39-35 | |
| » Starters: Steve Stone vs David Clyde | Third | 2 out |
| Tuesday, July 3 |
| » Defeated Rangers (26-48), 15-1 | Arlington Stadium (3-0) | 40-35 | Won 2 |
| » Starters: Wilbur Wood vs Pete Broberg | Third | 2½ out |
| » Lost to Rangers (27-48), 2-1 | Arlington Stadium (3-1) | 40-36 | |
| » Starters: Stan Bahnsen vs Jim Bibby | Third | 2½ out |
| » Major-league debuts: Pete Mackanin (Rangers) |
| Wednesday, July 4 |
| » Defeated Rangers (27-49), 2-0 | Arlington Stadium (4-1) | 41-36 | |
| » Starters: Jim Geddes vs Steve Dunning | Third | 2 out |
| » Defeated Rangers (27-50), 6-2 | Arlington Stadium (5-1) | 42-36 | Won 2 |
| » Starters: Bart Johnson vs Jim Kremmel | Third | 2 out |
| Thursday, July 5 |
| » Lost to Rangers (28-50), 7-2 | Arlington Stadium (5-2) | 42-37 | |
| » Starters: Steve Stone vs Sonny Siebert | Second | 1½ out |
| Friday, July 6 |
| » Lost to Red Sox (41-37), 5-2 | Comiskey Park I (20-20) | 42-38 | Lost 2 |
| » Starters: Luis Tiant vs Wilbur Wood | Fourth | 2 out |
| Saturday, July 7 |
| » Lost to Red Sox (42-37), 7-3 | Comiskey Park I (20-21) | 42-39 | Lost 3 |
| » Starters: John Curtis vs Stan Bahnsen | Fifth | 3 out |
| Sunday, July 8 |
| » Defeated Red Sox (42-38), 6-1 | Comiskey Park I (21-21) | 43-39 | |
| » Starters: Marty Pattin vs Steve Stone | Fifth | 3½ out |
| » Lost to Red Sox (43-38), 11-2 | Comiskey Park I (21-22) | 43-40 | |
| » Starters: Ray Culp vs Bart Johnson | Fifth | 3½ out |
| Monday, July 9 |
| » Defeated Yankees (48-40), 4-3 | Comiskey Park I (22-22) | 44-40 | |
| » Starters: Doc Medich vs Wilbur Wood | Fourth | 3 out |
| Tuesday, July 10 |
| » Defeated Yankees (48-41), 2-1 | Comiskey Park I (23-22) | 45-40 | Won 2 |
| » Starters: Lindy McDaniel vs Stan Bahnsen | Fourth | 2 out |
| Wednesday, July 11 |
| » Lost to Yankees (49-41), 2-1 | Comiskey Park I (23-23) | 45-41 | |
| » Starters: Fritz Peterson vs Steve Stone | Fifth | 3 out |
| Thursday, July 12 |
| » Lost to Orioles (44-38), 4-3 | Comiskey Park I (23-24) | 45-42 | Lost 2 |
| » Starters: Jesse Jefferson vs Bart Johnson | Fourth | 4 out |
| Friday, July 13 |
| » Defeated Orioles (44-39), 3-2 | Comiskey Park I (24-24) | 46-42 | |
| » Starters: Dave McNally vs Wilbur Wood | Third | 4 out |
| Saturday, July 14 |
| » Lost to Orioles (45-39), 5-4 | Comiskey Park I (24-25) | 46-43 | |
| » Starters: Jim Palmer vs Stan Bahnsen | Third | 4 out |
| Sunday, July 15 |
| » Lost to Orioles (46-39), 3-2 | Comiskey Park I (24-26) | 46-44 | Lost 2 |
| » Starters: Mike Cuellar vs Steve Stone | Fourth | 5 out |
| Monday, July 16 |
| » Lost to Red Sox (49-40), 9-8 | Fenway Park (2-1) | 46-45 | Lost 3 |
| » Starters: Bart Johnson vs John Curtis | Fifth | 5 out |
| Tuesday, July 17 |
| » Defeated Red Sox (49-41), 8-4 | Fenway Park (3-1) | 47-45 | |
| » Starters: Wilbur Wood vs Marty Pattin | Third | 4½ out |
| » Defeated Red Sox (49-42), 5-0 | Fenway Park (4-1) | 48-45 | Won 2 |
| » Starters: Stan Bahnsen vs Ray Culp | Third | 4½ out |
| Former White Sox Evar Swanson dies in Galesburg, IL at the age of 71. |
| Wednesday, July 18 |
| » Lost to Red Sox (50-42), 6-1 | Fenway Park (4-2) | 48-46 | |
| » Starters: Steve Stone vs Bill Lee | Third | 4½ out |
| Friday, July 20 |
| » Lost to Yankees (55-43), 12-2 | Yankee Stadium (2-1) | 48-47 | Lost 2 |
| » Starters: Wilbur Wood vs Doc Medich | Fourth | 6 out |
| » Lost to Yankees (56-43), 7-0 | Yankee Stadium (2-2) | 48-48 | Lost 3 |
| » Starters: Wilbur Wood vs Sam McDowell | Fourth | 6 out |
| Sunday, July 22 |
| » Defeated Yankees (56-44), 4-2 | Yankee Stadium (3-2) | 49-48 | |
| » Starters: Stan Bahnsen vs Mel Stottlemyre | Fifth | 7 out |
| » Lost to Yankees (57-44), 2-0 | Yankee Stadium (3-3) | 49-49 | |
| » Starters: Steve Stone vs Fritz Peterson | Fifth | 7 out |
| Thursday, July 26 |
| » Defeated Royals (55-47), 7-4 | Royals Stadium (3-1) | 50-49 | |
| » Starters: Wilbur Wood vs Dick Drago | Fourth | 6 out |
| » Lost to Royals (56-47), 1-0 | Royals Stadium (3-2) | 50-50 | |
| » Starters: Stan Bahnsen vs Paul Splittorff | Fourth | 6 out |
| » Major-league debuts: Jerry Hairston (White Sox) |
| Friday, July 27 |
| » Lost to Royals (57-47), 2-1 | Royals Stadium (3-3) | 50-51 | Lost 2 |
| » Starters: Steve Stone vs Steve Busby | Fourth | 6 out |
| Saturday, July 28 |
| » Lost to Twins (53-47), 6-5 | Metropolitan Stadium (1-2) | 50-52 | Lost 3 |
| » Starters: Bart Johnson vs Joe Decker | Fifth | 7 out |
| Sunday, July 29 |
| » Defeated Twins (53-48), 8-6 | Metropolitan Stadium (2-2) | 51-52 | |
| » Starters: Wilbur Wood vs Dave Goltz | Fourth | 6½ out |
| Monday, July 30 |
| » Defeated Twins (53-49), 9-1 | Metropolitan Stadium (3-2) | 52-52 | Won 2 |
| » Starters: Stan Bahnsen vs Jim Kaat | Fourth | 5½ out |
| Tuesday, July 31 |
| » Lost to Royals (60-48), 2-1 | Comiskey Park I (24-27) | 52-53 | |
| » Starters: Paul Splittorff vs Steve Stone | Fourth | 6½ out |
| Wednesday, August 1 |
| » Lost to Royals (61-48), 4-2 | Comiskey Park I (24-28) | 52-54 | Lost 2 |
| » Starters: Steve Busby vs Wilbur Wood | Fourth | 7½ out |
| Thursday, August 2 |
| » Lost to Royals (62-48), 3-1 | Comiskey Park I (24-29) | 52-55 | Lost 3 |
| » Starters: Dick Drago vs Stan Bahnsen | Fifth | 8½ out |
| » Major-league debuts: George Brett (Royals) |
| Friday, August 3 |
| » Defeated Rangers (40-66), 5-3 | Comiskey Park I (25-29) | 53-55 | |
| » Starters: Jim Bibby vs Steve Stone | Fourth | 8½ out |
| Saturday, August 4 |
| » Lost to Rangers (41-66), 9-3 | Comiskey Park I (25-30) | 53-56 | |
| » Starters: Jackie Brown vs Wilbur Wood | Fourth | 9½ out |
| Future White Sox Bobby Howry is born in Phoenix, AZ. |
| Sunday, August 5 |
| » Defeated Rangers (41-67), 7-3 | Comiskey Park I (26-30) | 54-56 | |
| » Starters: Don Durham vs Stan Bahnsen | Fourth | 8 out |
| » Defeated Rangers (41-68), 5-4 | Comiskey Park I (27-30) | 55-56 | Won 2 |
| » Starters: David Clyde vs Bart Johnson | Fourth | 8 out |
| Monday, August 6 |
| » Lost to Indians (43-70), 7-3 | Comiskey Park I (27-31) | 55-57 | |
| » Starters: Gaylord Perry vs Steve Stone | Fourth | 8½ out |
| Tuesday, August 7 |
| » Defeated Indians (43-71), 6-5 | Comiskey Park I (28-31) | 56-57 | |
| » Starters: Tom Timmermann vs Wilbur Wood | Fourth | 8½ out |
| Wednesday, August 8 |
| » Lost to Indians (44-71), 13-1 | Comiskey Park I (28-32) | 56-58 | |
| » Starters: Dick Tidrow vs Stan Bahnsen | Fourth | 8½ out |
| Thursday, August 9 |
| » Defeated Tigers (62-52), 5-4 | Tiger Stadium (2-1) | 57-58 | |
| » Starters: Terry Forster vs Joe Coleman | Fourth | 8½ out |
| Friday, August 10 |
| » Lost to Tigers (63-52), 7-3 | Tiger Stadium (2-2) | 57-59 | |
| » Starters: Steve Stone vs Mike Strahler | Fourth | 9½ out |
| Saturday, August 11 |
| » Lost to Tigers (64-52), 4-2 | Tiger Stadium (2-3) | 57-60 | Lost 2 |
| » Starters: Wilbur Wood vs Mickey Lolich | Fourth | 10½ out |
| Sunday, August 12 |
| » Lost to Tigers (65-52), 6-2 | Tiger Stadium (2-4) | 57-61 | Lost 3 |
| » Starters: Stan Bahnsen vs Jim Perry | Fourth | 10½ out |
| Monday, August 13 |
| » Defeated Brewers (57-59), 5-2 | County Stadium (1-3) | 58-61 | |
| » Starters: Terry Forster vs Jim Slaton | Third | 10 out |
| Tuesday, August 14 |
| » Lost to Brewers (58-59), 5-4 | County Stadium (1-4) | 58-62 | |
| » Starters: Steve Stone vs Bill Parsons | Fourth | 11 out |
| Wednesday, August 15 |
| » Lost to Brewers (59-59), 5-4 | County Stadium (1-5) | 58-63 | Lost 2 |
| » Starters: Wilbur Wood vs Jerry Bell | Fourth | 12 out |
| Friday, August 17 |
| » Lost to Orioles (66-52), 3-2 | Memorial Stadium (1-3) | 58-64 | Lost 3 |
| » Starters: Stan Bahnsen vs Jim Palmer | Fourth | 12½ out |
| Saturday, August 18 |
| » Lost to Orioles (67-52), 3-0 | Memorial Stadium (1-4) | 58-65 | Lost 4 |
| » Starters: Terry Forster vs Mike Cuellar | Fourth | 13½ out |
| Sunday, August 19 |
| » Lost to Orioles (68-52), 8-2 | Memorial Stadium (1-5) | 58-66 | Lost 5 |
| » Starters: Wilbur Wood vs Dave McNally | Fourth | 14½ out |
| Tuesday, August 21 |
| » Defeated Indians (51-75), 4-0 | Cleveland Stadium (4-1) | 59-66 | |
| » Starters: Stan Bahnsen vs Dick Tidrow | Fourth | 14 out |
| Former White Sox Ira Hutchinson dies in Chicago, IL at the age of 63. |
| Wednesday, August 22 |
| » Lost to Indians (52-75), 1-0 | Cleveland Stadium (4-2) | 59-67 | |
| » Starters: Terry Forster vs Gaylord Perry | Fourth | 15 out |
| Friday, August 24 |
| » Lost to Tigers (69-58), 6-5 | Comiskey Park I (28-33) | 59-68 | Lost 2 |
| » Starters: Mickey Lolich vs Wilbur Wood | Fifth | 16 out |
| Saturday, August 25 |
| » Lost to Tigers (70-58), 4-2 | Comiskey Park I (28-34) | 59-69 | Lost 3 |
| » Starters: Jim Perry vs Stan Bahnsen | Fifth | 17 out |
| Sunday, August 26 |
| » Defeated Tigers (70-59), 4-1 | Comiskey Park I (29-34) | 60-69 | |
| » Starters: Joe Coleman vs Jim Kaat | Fourth | 16½ out |
| » Defeated Tigers (70-60), 3-1 | Comiskey Park I (30-34) | 61-69 | Won 2 |
| » Starters: Woodie Fryman vs Terry Forster | Fourth | 16½ out |
| Monday, August 27 |
| » Defeated Brewers (62-66), 6-1 | Comiskey Park I (31-34) | 62-69 | Won 3 |
| » Starters: Bill Champion vs Wilbur Wood | Fourth | 15½ out |
| Tuesday, August 28 |
| » Defeated Brewers (62-67), 6-4 | Comiskey Park I (32-34) | 63-69 | Won 4 |
| » Starters: Skip Lockwood vs Steve Stone | Fourth | 15½ out |
| Wednesday, August 29 |
| » Lost to Brewers (63-67), 9-0 | Comiskey Park I (32-35) | 63-70 | |
| » Starters: Jim Colborn vs Stan Bahnsen | Fourth | 15½ out |
| Friday, August 31 |
| » Defeated Angels (61-68), 7-2 | Comiskey Park I (33-35) | 64-70 | |
| » Starters: Bill Singer vs Wilbur Wood | Fourth | 15½ out |
| Saturday, September 1 |
| » Defeated Angels (61-69), 7-5 | Comiskey Park I (34-35) | 65-70 | Won 2 |
| » Starters: Rudy May vs Jim Kaat | Fourth | 14½ out |
| Sunday, September 2 |
| » Defeated Angels (61-70), 13-3 | Comiskey Park I (35-35) | 66-70 | Won 3 |
| » Starters: Clyde Wright vs Stan Bahnsen | Third | 13½ out |
| Monday, September 3 |
| » Defeated Rangers (47-89), 8-7 | Comiskey Park I (36-35) | 67-70 | Won 4 |
| » Starters: Rick Henninger vs Wilbur Wood | Third | 12 out |
| » Defeated Rangers (47-90), 5-2 | Comiskey Park I (37-35) | 68-70 | Won 5 |
| » Starters: Jim Merritt vs Terry Forster | Third | 12 out |
| Tuesday, September 4 |
| » Defeated Rangers (47-91), 14-0 | Comiskey Park I (38-35) | 69-70 | Won 6 |
| » Starters: Jim Bibby vs Jim Kaat | Third | 12 out |
| Future White Sox Brian Simmons is born in Lebanon, PA. |
| Wednesday, September 5 |
| Former White Sox Jack Fournier dies in Tacoma, WA at the age of 84. |
| Thursday, September 6 |
| » Defeated Twins (67-71), 6-0 | Metropolitan Stadium (4-2) | 70-70 | Won 7 |
| » Starters: Stan Bahnsen vs Danny Fife | Third | 12½ out |
| Friday, September 7 |
| » Defeated Twins (67-72), 5-2 | Metropolitan Stadium (5-2) | 71-70 | Won 8 |
| » Starters: Wilbur Wood vs Joe Decker | Third | 11½ out |
| Saturday, September 8 |
| » Lost to Twins (68-72), 6-2 | Metropolitan Stadium (5-3) | 71-71 | |
| » Starters: Terry Forster vs Dave Goltz | Third | 11½ out |
| » Major-league debuts: Craig Kusick (Twins) |
| Sunday, September 9 |
| » Defeated Twins (68-73), 10-7 | Metropolitan Stadium (6-3) | 72-71 | |
| » Starters: Jim Kaat vs Bert Blyleven | Third | 10½ out |
| Monday, September 10 |
| » Lost to Angels (65-75), 7-1 | Anaheim Stadium (3-4) | 72-72 | |
| » Starters: Stan Bahnsen vs Dick Lange | Third | 11½ out |
| Tuesday, September 11 |
| » Lost to Angels (66-75), 3-1 | Anaheim Stadium (3-5) | 72-73 | Lost 2 |
| » Starters: Wilbur Wood vs Nolan Ryan | Third | 12½ out |
| » Major-league debuts: Sam Ewing (White Sox) |
| Wednesday, September 12 |
| » Lost to Angels (67-75), 6-5 | Anaheim Stadium (3-6) | 72-74 | Lost 3 |
| » Starters: Terry Forster vs Bill Singer | Third | 12½ out |
| Friday, September 14 |
| » Lost to Twins (71-74), 6-0 | Comiskey Park I (38-36) | 72-75 | Lost 4 |
| » Starters: Bert Blyleven vs Stan Bahnsen | Fourth | 13½ out |
| Former White Sox Sloppy Thurston dies in Los Angeles, CA at the age of 75. |
| Saturday, September 15 |
| » Defeated Twins (71-75), 11-4 | Comiskey Park I (39-36) | 73-75 | |
| » Starters: Joe Decker vs Wilbur Wood | Third | 13½ out |
| Sunday, September 16 |
| » Lost to Twins (72-75), 6-1 | Comiskey Park I (39-37) | 73-76 | |
| » Starters: Dave Goltz vs Terry Forster | Fourth | 14½ out |
| Monday, September 17 |
| » Lost to Rangers (52-96), 10-3 | Arlington Stadium (5-3) | 73-77 | Lost 2 |
| » Starters: Jim Kaat vs Sonny Siebert | Fourth | 15½ out |
| » Major-league debuts: Rick Waits (Rangers) |
| Tuesday, September 18 |
| » Lost to Rangers (53-96), 7-2 | Arlington Stadium (5-4) | 73-78 | Lost 3 |
| » Starters: Stan Bahnsen vs Jim Bibby | Fourth | 16½ out |
| Former White Sox Dave Harris dies in Atlanta, GA at the age of 74. |
| Wednesday, September 19 |
| » Defeated Royals (82-70), 4-3 | Royals Stadium (4-3) | 74-78 | |
| » Starters: Wilbur Wood vs Gene Garber | Fourth | 16½ out |
| Thursday, September 20 |
| » Lost to Royals (83-70), 10-3 | Royals Stadium (4-4) | 74-79 | |
| » Starters: Terry Forster vs Paul Splittorff | Fourth | 16 out |
| Friday, September 21 |
| » Defeated Royals (83-71), 6-5 | Royals Stadium (5-4) | 75-79 | |
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