| Monday, March 12 |
| Future Padre David Lee is born in Pittsburgh, PA. |
| Tuesday, March 13 |
| Future Padre Dario Veras is born in Santiago, D.R. |
| Monday, April 2 |
| Future Padre Marc Kroon is born in Bronx, NY. |
| Thursday, April 5 |
| » Major-league debuts: Gene Locklear (Reds) |
| Friday, April 6 |
| » Defeated Dodgers (0-1), 4-2 | San Diego/Jack Murphy Stadium (1-0) | 1-0 | |
| » Starters: Don Sutton vs Clay Kirby | First | -- |
| » Major-league debuts: Bob Davis (Padres) |
| Saturday, April 7 |
| » Defeated Dodgers (0-2), 4-3 | San Diego/Jack Murphy Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Andy Messersmith vs Fred Norman | First | -- |
| Sunday, April 8 |
| » Lost to Dodgers (1-2), 4-0 | San Diego/Jack Murphy Stadium (2-1) | 2-1 | |
| » Starters: Tommy John vs Steve Arlin | First | -- |
| Monday, April 9 |
| » Lost to Giants (3-1), 2-1 | Candlestick Park (0-1) | 2-2 | Lost 2 |
| » Starters: Mike Caldwell vs Ron Bryant | Second | 1 out |
| » Major-league debuts: Rich Troedson (Padres) |
| Tuesday, April 10 |
| » Lost to Giants (4-1), 11-2 | Candlestick Park (0-2) | 2-3 | Lost 3 |
| » Starters: Mike Corkins vs Juan Marichal | Third | 2 out |
| Wednesday, April 11 |
| » Lost to Braves (2-3), 8-1 | San Diego/Jack Murphy Stadium (2-2) | 2-4 | Lost 4 |
| » Starters: Gary Gentry vs Clay Kirby | Fifth | 3 out |
| Thursday, April 12 |
| » Lost to Braves (3-3), 3-2 | San Diego/Jack Murphy Stadium (2-3) | 2-5 | Lost 5 |
| » Starters: Pat Dobson vs Fred Norman | Fifth | 4 out |
| Friday, April 13 |
| » Defeated Astros (4-4), 5-4 | San Diego/Jack Murphy Stadium (3-3) | 3-5 | |
| » Starters: Don Wilson vs Steve Arlin | Fifth | 4 out |
| Saturday, April 14 |
| » Lost to Astros (5-4), 8-5 | San Diego/Jack Murphy Stadium (3-4) | 3-6 | |
| » Starters: Jerry Reuss vs Mike Caldwell | Fifth | 4 out |
| Sunday, April 15 |
| » Defeated Astros (5-5), 5-1 | San Diego/Jack Murphy Stadium (4-4) | 4-6 | |
| » Starters: Dave Roberts vs Mike Corkins | Third | 2½ out |
| » Defeated Astros (5-6), 4-0 | San Diego/Jack Murphy Stadium (5-4) | 5-6 | Won 2 |
| » Starters: Tom Griffin vs Bill Greif | Third | 2½ out |
| Monday, April 16 |
| » Lost to Reds (8-3), 7-6 | San Diego/Jack Murphy Stadium (5-5) | 5-7 | |
| » Starters: Jack Billingham vs Clay Kirby | Fourth | 3½ out |
| Tuesday, April 17 |
| » Lost to Reds (9-3), 3-0 | San Diego/Jack Murphy Stadium (5-6) | 5-8 | Lost 2 |
| » Starters: Ross Grimsley vs Fred Norman | Fourth | 4½ out |
| Wednesday, April 18 |
| » Defeated Reds (9-4), 4-2 | San Diego/Jack Murphy Stadium (6-6) | 6-8 | |
| » Starters: Roger Nelson vs Steve Arlin | Fourth | 4 out |
| Thursday, April 19 |
| Future Padre Heath Murray is born in Troy, OH. |
| Friday, April 20 |
| » Lost to Astros (7-8), 6-2 | Astrodome (0-1) | 6-9 | |
| » Starters: Mike Corkins vs Ken Forsch | Fourth | 5½ out |
| Saturday, April 21 |
| » Lost to Astros (8-8), 4-0 | Astrodome (0-2) | 6-10 | Lost 2 |
| » Starters: Clay Kirby vs Don Wilson | Fifth | 5½ out |
| Sunday, April 22 |
| » Lost to Astros (9-8), 4-3 | Astrodome (0-3) | 6-11 | Lost 3 |
| » Starters: Fred Norman vs Jerry Reuss | Fifth | 6½ out |
| Monday, April 23 |
| » Lost to Astros (10-8), 2-0 | Astrodome (0-4) | 6-12 | Lost 4 |
| » Starters: Bill Greif vs Dave Roberts | Fifth | 7 out |
| Tuesday, April 24 |
| » Defeated Pirates (8-4), 7-5 | Three Rivers Stadium (1-0) | 7-12 | |
| » Starters: Steve Arlin vs Bob Moose | Fifth | 7 out |
| Friday, April 27 |
| » Lost to Cubs (10-8), 10-2 | Wrigley Field (0-1) | 7-13 | |
| » Starters: Clay Kirby vs Milt Pappas | Sixth | 9 out |
| Saturday, April 28 |
| » Lost to Cubs (11-8), 2-0 | Wrigley Field (0-2) | 7-14 | Lost 2 |
| » Starters: Fred Norman vs Rick Reuschel | Sixth | 10 out |
| Sunday, April 29 |
| » Lost to Cubs (12-8), 10-4 | Wrigley Field (0-3) | 7-15 | Lost 3 |
| » Starters: Steve Arlin vs Fergie Jenkins | Sixth | 10 out |
| Tuesday, May 1 |
| » Defeated Cardinals (3-16), 10-5 | San Diego/Jack Murphy Stadium (7-6) | 8-15 | |
| » Starters: Scipio Spinks vs Mike Corkins | Fifth | 10 out |
| Wednesday, May 2 |
| » Lost to Cardinals (4-16), 5-4 | San Diego/Jack Murphy Stadium (7-7) | 8-16 | |
| » Starters: Bob Gibson vs Clay Kirby | Fifth | 10 out |
| Thursday, May 3 |
| » Lost to Cardinals (5-16), 3-1 | San Diego/Jack Murphy Stadium (7-8) | 8-17 | Lost 2 |
| » Starters: Reggie Cleveland vs Bill Greif | Fifth | 10 out |
| Friday, May 4 |
| » Lost to Pirates (11-8), 12-6 | San Diego/Jack Murphy Stadium (7-9) | 8-18 | Lost 3 |
| » Starters: Steve Blass vs Fred Norman | Fifth | 11 out |
| Saturday, May 5 |
| » Defeated Pirates (11-9), 6-5 | San Diego/Jack Murphy Stadium (8-9) | 9-18 | |
| » Starters: Dock Ellis vs Mike Corkins | Sixth | 10 out |
| Sunday, May 6 |
| » Defeated Pirates (11-10), 8-0 | San Diego/Jack Murphy Stadium (9-9) | 10-18 | Won 2 |
| » Starters: Bob Moose vs Mike Caldwell | Sixth | 10½ out |
| Monday, May 7 |
| » Defeated Cubs (15-13), 4-1 | San Diego/Jack Murphy Stadium (10-9) | 11-18 | Won 3 |
| » Starters: Rick Reuschel vs Bill Greif | Fifth | 10 out |
| Tuesday, May 8 |
| » Lost to Cubs (16-13), 3-2 | San Diego/Jack Murphy Stadium (10-10) | 11-19 | |
| » Starters: Fergie Jenkins vs Fred Norman | Sixth | 11 out |
| Wednesday, May 9 |
| » Lost to Cubs (17-13), 9-2 | San Diego/Jack Murphy Stadium (10-11) | 11-20 | Lost 2 |
| » Starters: Burt Hooton vs Mike Corkins | Sixth | 11 out |
| Saturday, May 12 |
| » Lost to Braves (11-18), 14-2 | Atlanta-Fulton County Stadium (0-1) | 11-21 | Lost 3 |
| » Starters: Mike Caldwell vs Gary Gentry | Sixth | 12 out |
| Sunday, May 13 |
| » Defeated Braves (11-19), 6-4 | Atlanta-Fulton County Stadium (1-1) | 12-21 | |
| » Starters: Bill Greif vs Pat Dobson | Sixth | 11½ out |
| » Lost to Braves (12-19), 6-2 | Atlanta-Fulton County Stadium (1-2) | 12-22 | |
| » Starters: Fred Norman vs Ron Reed | Sixth | 11½ out |
| Monday, May 14 |
| » Defeated Giants (25-13), 7-1 | San Diego/Jack Murphy Stadium (11-11) | 13-22 | |
| » Starters: Tom Bradley vs Mike Corkins | Sixth | 10½ out |
| Tuesday, May 15 |
| » Lost to Giants (26-13), 4-2 | San Diego/Jack Murphy Stadium (11-12) | 13-23 | |
| » Starters: Ron Bryant vs Vicente Romo | Sixth | 11½ out |
| Wednesday, May 16 |
| » Defeated Giants (26-14), 4-1 | San Diego/Jack Murphy Stadium (12-12) | 14-23 | |
| » Starters: Juan Marichal vs Mike Caldwell | Sixth | 10½ out |
| Friday, May 18 |
| » Lost to Reds (21-15), 5-4 | Riverfront Stadium (0-1) | 14-24 | |
| » Starters: Bill Greif vs Jack Billingham | Sixth | 10½ out |
| Saturday, May 19 |
| » Lost to Reds (22-15), 10-4 | Riverfront Stadium (0-2) | 14-25 | Lost 2 |
| » Starters: Mike Corkins vs Jim McGlothlin | Sixth | 10½ out |
| Sunday, May 20 |
| » Defeated Reds (22-16), 2-1 | Riverfront Stadium (1-2) | 15-25 | |
| » Starters: Fred Norman vs Ross Grimsley | Sixth | 11 out |
| » Lost to Reds (23-16), 3-2 | Riverfront Stadium (1-3) | 15-26 | |
| » Starters: Mike Caldwell vs Don Gullett | Sixth | 11 out |
| Tuesday, May 22 |
| » Lost to Dodgers (24-17), 5-1 | Dodger Stadium (0-1) | 15-27 | Lost 2 |
| » Starters: Bill Greif vs Don Sutton | Sixth | 11½ out |
| Wednesday, May 23 |
| » Defeated Dodgers (24-18), 4-3 | Dodger Stadium (1-1) | 16-27 | |
| » Starters: Mike Corkins vs Andy Messersmith | Sixth | 11 out |
| Friday, May 25 |
| » Lost to Phillies (16-24), 8-1 | San Diego/Jack Murphy Stadium (12-13) | 16-28 | |
| » Starters: Ken Brett vs Fred Norman | Sixth | 10½ out |
| Saturday, May 26 |
| » Lost to Phillies (17-24), 4-0 | San Diego/Jack Murphy Stadium (12-14) | 16-29 | Lost 2 |
| » Starters: Steve Carlton vs Mike Caldwell | Sixth | 11½ out |
| Sunday, May 27 |
| » Lost to Phillies (18-24), 4-3 | San Diego/Jack Murphy Stadium (12-15) | 16-30 | Lost 3 |
| » Starters: Wayne Twitchell vs Bill Greif | Sixth | 13 out |
| » Lost to Phillies (19-24), 6-4 | San Diego/Jack Murphy Stadium (12-16) | 16-31 | Lost 4 |
| » Starters: Larry Christenson vs Steve Arlin | Sixth | 13 out |
| Monday, May 28 |
| » Lost to Expos (18-21), 7-6 | San Diego/Jack Murphy Stadium (12-17) | 16-32 | Lost 5 |
| » Starters: Ernie McAnally vs Mike Corkins | Sixth | 14 out |
| Wednesday, May 30 |
| » Lost to Expos (19-21), 5-3 | San Diego/Jack Murphy Stadium (12-18) | 16-33 | Lost 6 |
| » Starters: Bill Stoneman vs Fred Norman | Sixth | 14 out |
| » Defeated Expos (19-22), 3-2 | San Diego/Jack Murphy Stadium (13-18) | 17-33 | |
| » Starters: Mike Torrez vs Mike Caldwell | Sixth | 14 out |
| Friday, June 1 |
| » Defeated Mets (21-23), 4-0 | San Diego/Jack Murphy Stadium (14-18) | 18-33 | Won 2 |
| » Starters: Jerry Koosman vs Bill Greif | Sixth | 14 out |
| Saturday, June 2 |
| » Defeated Mets (21-24), 3-0 | San Diego/Jack Murphy Stadium (15-18) | 19-33 | Won 3 |
| » Starters: George Stone vs Clay Kirby | Sixth | 14 out |
| Sunday, June 3 |
| » Lost to Mets (22-24), 9-2 | San Diego/Jack Murphy Stadium (15-19) | 19-34 | |
| » Starters: Tom Seaver vs Mike Caldwell | Sixth | 15 out |
| Monday, June 4 |
| Future Padre David Lundquist is born in Beverly, MA. |
| Tuesday, June 5 |
| » Lost to Cardinals (23-25), 5-3 | Busch Stadium II (0-1) | 19-35 | Lost 2 |
| » Starters: Bill Greif vs Alan Foster | Sixth | 16½ out |
| Wednesday, June 6 |
| » Lost to Cardinals (24-25), 6-3 | Busch Stadium II (0-2) | 19-36 | Lost 3 |
| » Starters: Clay Kirby vs Bob Gibson | Sixth | 17½ out |
| Thursday, June 7 |
| » Defeated Cardinals (24-26), 4-3 | Busch Stadium II (1-2) | 20-36 | |
| » Starters: Mike Caldwell vs Reggie Cleveland | Sixth | 17 out |
| Friday, June 8 |
| » Lost to Phillies (21-32), 5-1 | Veteran's Stadium (0-1) | 20-37 | |
| » Starters: Steve Arlin vs Steve Carlton | Sixth | 17 out |
| Saturday, June 9 |
| » Lost to Phillies (22-32), 4-1 | Veteran's Stadium (0-2) | 20-38 | Lost 2 |
| » Starters: Bill Greif vs Ken Brett | Sixth | 17 out |
| Sunday, June 10 |
| » Lost to Phillies (23-32), 11-0 | Veteran's Stadium (0-3) | 20-39 | Lost 3 |
| » Starters: Clay Kirby vs Wayne Twitchell | Sixth | 17 out |
| Tuesday, June 12 |
| » Lost to Expos (26-25), 7-4 | Parc Jarry (0-1) | 20-40 | Lost 4 |
| » Starters: Mike Caldwell vs Mike Torrez | Sixth | 17½ out |
| Wednesday, June 13 |
| » Lost to Expos (27-25), 3-2 | Parc Jarry (0-2) | 20-41 | Lost 5 |
| » Starters: Bill Greif vs Balor Moore | Sixth | 17½ out |
| Thursday, June 14 |
| » Lost to Expos (28-25), 5-3 | Parc Jarry (0-3) | 20-42 | Lost 6 |
| » Starters: Clay Kirby vs Steve Renko | Sixth | 18 out |
| Friday, June 15 |
| » Lost to Mets (26-29), 5-2 | Shea Stadium (0-1) | 20-43 | Lost 7 |
| » Starters: Steve Arlin vs Jon Matlack | Sixth | 19 out |
| Saturday, June 16 |
| » Lost to Mets (27-29), 10-2 | Shea Stadium (0-2) | 20-44 | Lost 8 |
| » Starters: Mike Caldwell vs Jerry Koosman | Sixth | 19 out |
| » Major-league debuts: Randy Jones (Padres) |
| Sunday, June 17 |
| » Lost to Mets (28-29), 3-1 | Shea Stadium (0-3) | 20-45 | Lost 9 |
| » Starters: Bill Greif vs George Stone | Sixth | 19½ out |
| Tuesday, June 19 |
| » Lost to Astros (37-30), 7-3 | San Diego/Jack Murphy Stadium (15-20) | 20-46 | Lost 10 |
| » Starters: Jerry Reuss vs Clay Kirby | Sixth | 21 out |
| » Major-league debuts: Dave Winfield (Padres) |
| Wednesday, June 20 |
| » Defeated Astros (37-31), 6-2 | San Diego/Jack Murphy Stadium (16-20) | 21-46 | |
| » Starters: Dave Roberts vs Steve Arlin | Sixth | 21 out |
| Thursday, June 21 |
| » Lost to Astros (38-31), 12-2 | San Diego/Jack Murphy Stadium (16-21) | 21-47 | |
| » Starters: Ken Forsch vs Bill Greif | Sixth | 22 out |
| Friday, June 22 |
| » Lost to Braves (29-40), 7-3 | San Diego/Jack Murphy Stadium (16-22) | 21-48 | Lost 2 |
| » Starters: Phil Niekro vs Randy Jones | Sixth | 23 out |
| Saturday, June 23 |
| » Defeated Braves (29-41), 2-0 | San Diego/Jack Murphy Stadium (17-22) | 22-48 | |
| » Starters: Ron Reed vs Clay Kirby | Sixth | 22 out |
| » Defeated Braves (29-42), 9-3 | San Diego/Jack Murphy Stadium (18-22) | 23-48 | Won 2 |
| » Starters: Jimmy Freeman vs Rich Troedson | Sixth | 22 out |
| Sunday, June 24 |
| » Lost to Braves (30-42), 6-1 | San Diego/Jack Murphy Stadium (18-23) | 23-49 | |
| » Starters: Carl Morton vs Steve Arlin | Sixth | 23 out |
| Monday, June 25 |
| » Lost to Dodgers (47-26), 3-2 | San Diego/Jack Murphy Stadium (18-24) | 23-50 | Lost 2 |
| » Starters: Claude Osteen vs Bill Greif | Fifth | 24 out |
| Tuesday, June 26 |
| » Lost to Dodgers (48-26), 7-0 | San Diego/Jack Murphy Stadium (18-25) | 23-51 | Lost 3 |
| » Starters: Don Sutton vs Randy Jones | Fifth | 25 out |
| Thursday, June 28 |
| » Defeated Reds (38-36), 6-1 | Riverfront Stadium (2-3) | 24-51 | |
| » Starters: Clay Kirby vs Don Gullett | Sixth | 24½ out |
| Friday, June 29 |
| » Lost to Reds (39-36), 4-0 | Riverfront Stadium (2-4) | 24-52 | |
| » Starters: Rich Troedson vs Jack Billingham | Sixth | 25½ out |
| Saturday, June 30 |
| » Defeated Astros (43-36), 3-0 | Astrodome (1-4) | 25-52 | |
| » Starters: Steve Arlin vs Ken Forsch | Sixth | 25½ out |
| Sunday, July 1 |
| » Lost to Astros (44-36), 6-4 | Astrodome (1-5) | 25-53 | |
| » Starters: Bill Greif vs Don Wilson | Sixth | 25 out |
| Monday, July 2 |
| » Defeated Astros (44-37), 8-5 | Astrodome (2-5) | 26-53 | |
| » Starters: Clay Kirby vs Jerry Reuss | Sixth | 24 out |
| Tuesday, July 3 |
| » Defeated Dodgers (51-31), 4-1 | Dodger Stadium (2-1) | 27-53 | Won 2 |
| » Starters: Randy Jones vs Tommy John | Sixth | 23 out |
| Wednesday, July 4 |
| » Defeated Dodgers (51-32), 4-2 | Dodger Stadium (3-1) | 28-53 | Won 3 |
| » Starters: Rich Troedson vs Al Downing | Sixth | 22 out |
| Thursday, July 5 |
| » Defeated Dodgers (51-33), 3-0 | Dodger Stadium (4-1) | 29-53 | Won 4 |
| » Starters: Steve Arlin vs Claude Osteen | Sixth | 21 out |
| Friday, July 6 |
| » Lost to Cubs (50-35), 8-5 | San Diego/Jack Murphy Stadium (18-26) | 29-54 | |
| » Starters: Fergie Jenkins vs Clay Kirby | Sixth | 22 out |
| Saturday, July 7 |
| » Defeated Cubs (50-36), 4-3 | San Diego/Jack Murphy Stadium (19-26) | 30-54 | |
| » Starters: Milt Pappas vs Bill Greif | Sixth | 22 out |
| Sunday, July 8 |
| » Defeated Cubs (50-37), 4-2 | San Diego/Jack Murphy Stadium (20-26) | 31-54 | Won 2 |
| » Starters: Burt Hooton vs Randy Jones | Sixth | 22 out |
| Tuesday, July 10 |
| » Lost to Pirates (38-45), 4-3 | San Diego/Jack Murphy Stadium (20-27) | 31-55 | |
| » Starters: Bob Moose vs Rich Troedson | Sixth | 22 out |
| Wednesday, July 11 |
| » Lost to Pirates (39-45), 10-2 | San Diego/Jack Murphy Stadium (20-28) | 31-56 | Lost 2 |
| » Starters: Nelson Briles vs Steve Arlin | Sixth | 23 out |
| Thursday, July 12 |
| » Lost to Pirates (40-45), 4-0 | San Diego/Jack Murphy Stadium (20-29) | 31-57 | Lost 3 |
| » Starters: Luke Walker vs Clay Kirby | Sixth | 24 out |
| » Major-league debuts: Dave Parker (Pirates) |
| Friday, July 13 |
| » Lost to Cardinals (45-42), 5-3 | San Diego/Jack Murphy Stadium (20-30) | 31-58 | Lost 4 |
| » Starters: Rick Wise vs Bill Greif | Sixth | 25 out |
| Saturday, July 14 |
| » Lost to Cardinals (46-42), 5-3 | San Diego/Jack Murphy Stadium (20-31) | 31-59 | Lost 5 |
| » Starters: Alan Foster vs Randy Jones | Sixth | 26 out |
| Sunday, July 15 |
| » Lost to Cardinals (47-42), 5-4 | San Diego/Jack Murphy Stadium (20-32) | 31-60 | Lost 6 |
| » Starters: Tom Murphy vs Rich Troedson | Sixth | 27 out |
| Tuesday, July 17 |
| » Defeated Cubs (51-42), 1-0 | Wrigley Field (1-3) | 32-60 | |
| » Starters: Steve Arlin vs Milt Pappas | Sixth | 27½ out |
| Wednesday, July 18 |
| » Defeated Cubs (51-43), 8-5 | Wrigley Field (2-3) | 33-60 | Won 2 |
| » Starters: Clay Kirby vs Fergie Jenkins | Sixth | 26½ out |
| Thursday, July 19 |
| » Lost to Cubs (52-43), 12-5 | Wrigley Field (2-4) | 33-61 | |
| » Starters: Bill Greif vs Burt Hooton | Sixth | 27½ out |
| Friday, July 20 |
| » Lost to Pirates (43-49), 5-4 | Three Rivers Stadium (1-1) | 33-62 | Lost 2 |
| » Starters: Randy Jones vs John Morlan | Sixth | 29 out |
| » Lost to Pirates (44-49), 7-0 | Three Rivers Stadium (1-2) | 33-63 | Lost 3 |
| » Starters: Rich Troedson vs Jim Rooker | Sixth | 29 out |
| » Major-league debuts: John Morlan (Pirates) |
| Saturday, July 21 |
| Future Padre Brian Buchanan is born in Miami, FL. |
| Sunday, July 22 |
| » Lost to Pirates (45-49), 3-1 | Three Rivers Stadium (1-3) | 33-64 | Lost 4 |
| » Starters: Steve Arlin vs Nelson Briles | Sixth | 29 out |
| » Lost to Pirates (46-49), 13-7 | Three Rivers Stadium (1-4) | 33-65 | Lost 5 |
| » Starters: Clay Kirby vs Luke Walker | Sixth | 29 out |
| Thursday, July 26 |
| » Lost to Giants (57-43), 10-2 | Candlestick Park (0-3) | 33-66 | Lost 6 |
| » Starters: Steve Arlin vs Ron Bryant | Fifth | 30½ out |
| » Lost to Giants (58-43), 6-5 | Candlestick Park (0-4) | 33-67 | Lost 7 |
| » Starters: Clay Kirby vs Jim Willoughby | Fifth | 30½ out |
| Friday, July 27 |
| » Defeated Giants (58-44), 6-2 | Candlestick Park (1-4) | 34-67 | |
| » Starters: Bill Greif vs Juan Marichal | Sixth | 29½ out |
| Saturday, July 28 |
| » Lost to Reds (60-43), 2-1 | San Diego/Jack Murphy Stadium (20-33) | 34-68 | |
| » Starters: Tom Hall vs Randy Jones | Sixth | 29½ out |
| Sunday, July 29 |
| » Defeated Reds (60-44), 7-1 | San Diego/Jack Murphy Stadium (21-33) | 35-68 | |
| » Starters: Gary Nolan vs Rich Troedson | Sixth | 30 out |
| » Lost to Reds (61-44), 4-2 | San Diego/Jack Murphy Stadium (21-34) | 35-69 | |
| » Starters: Roger Nelson vs Mike Caldwell | Sixth | 30 out |
| Tuesday, July 31 |
| » Lost to Giants (60-46), 5-1 | San Diego/Jack Murphy Stadium (21-35) | 35-70 | Lost 2 |
| » Starters: Juan Marichal vs Steve Arlin | Sixth | 30½ out |
| Wednesday, August 1 |
| » Defeated Giants (60-47), 6-5 | San Diego/Jack Murphy Stadium (22-35) | 36-70 | |
| » Starters: Jim Barr vs Clay Kirby | Sixth | 29½ out |
| Friday, August 3 |
| » Lost to Braves (50-63), 5-4 | Atlanta-Fulton County Stadium (1-3) | 36-71 | |
| » Starters: Bill Greif vs Ron Schueler | Sixth | 31 out |
| Saturday, August 4 |
| » Defeated Braves (50-64), 4-3 | Atlanta-Fulton County Stadium (2-3) | 37-71 | |
| » Starters: Randy Jones vs Gary Neibauer | Sixth | 30½ out |
| » Lost to Braves (51-64), 14-3 | Atlanta-Fulton County Stadium (2-4) | 37-72 | |
| » Starters: Rich Troedson vs Carl Morton | Sixth | 30½ out |
| Sunday, August 5 |
| » Lost to Braves (52-64), 9-0 | Atlanta-Fulton County Stadium (2-5) | 37-73 | Lost 2 |
| » Starters: Steve Arlin vs Phil Niekro | Sixth | 31½ out |
| Monday, August 6 |
| » Lost to Dodgers (70-42), 2-0 | San Diego/Jack Murphy Stadium (22-36) | 37-74 | Lost 3 |
| » Starters: Al Downing vs Clay Kirby | Sixth | 32½ out |
| Tuesday, August 7 |
| » Lost to Dodgers (71-42), 6-1 | San Diego/Jack Murphy Stadium (22-37) | 37-75 | Lost 4 |
| » Starters: Don Sutton vs Rich Troedson | Sixth | 33½ out |
| Wednesday, August 8 |
| » Defeated Phillies (52-61), 3-0 | San Diego/Jack Murphy Stadium (23-37) | 38-75 | |
| » Starters: Steve Carlton vs Bill Greif | Sixth | 32½ out |
| Thursday, August 9 |
| » Defeated Phillies (52-62), 10-9 | San Diego/Jack Murphy Stadium (24-37) | 39-75 | Won 2 |
| » Starters: Jim Lonborg vs Randy Jones | Sixth | 32½ out |
| Friday, August 10 |
| » Defeated Expos (56-58), 4-3 | San Diego/Jack Murphy Stadium (25-37) | 40-75 | Won 3 |
| » Starters: Balor Moore vs Steve Arlin | Sixth | 31½ out |
| Saturday, August 11 |
| » Major-league debuts: Hector Cruz (Cardinals) |
| Sunday, August 12 |
| » Lost to Expos (57-58), 2-0 | San Diego/Jack Murphy Stadium (25-38) | 40-76 | |
| » Starters: Steve Rogers vs Clay Kirby | Sixth | 31½ out |
| » Defeated Expos (57-59), 4-3 | San Diego/Jack Murphy Stadium (26-38) | 41-76 | |
| » Starters: Steve Renko vs Rich Troedson | Sixth | 31½ out |
| Monday, August 13 |
| » Defeated Mets (52-64), 3-2 | San Diego/Jack Murphy Stadium (27-38) | 42-76 | Won 2 |
| » Starters: Jon Matlack vs Bill Greif | Sixth | 31½ out |
| Tuesday, August 14 |
| » Defeated Mets (52-65), 9-0 | San Diego/Jack Murphy Stadium (28-38) | 43-76 | Won 3 |
| » Starters: Jerry Koosman vs Randy Jones | Sixth | 31½ out |
| Wednesday, August 15 |
| » Lost to Mets (53-65), 7-0 | San Diego/Jack Murphy Stadium (28-39) | 43-77 | |
| » Starters: Tom Seaver vs Steve Arlin | Sixth | 32½ out |
| Thursday, August 16 |
| Future Padre Damian Jackson is born in Los Angeles, CA. |
| Friday, August 17 |
| » Defeated Cardinals (62-60), 4-2 | Busch Stadium II (2-2) | 44-77 | |
| » Starters: Clay Kirby vs Reggie Cleveland | Sixth | 31½ out |
| Saturday, August 18 |
| » Defeated Cardinals (62-61), 4-3 | Busch Stadium II (3-2) | 45-77 | Won 2 |
| » Starters: Rich Troedson vs Mike Nagy | Sixth | 30½ out |
| Sunday, August 19 |
| » Lost to Cardinals (63-61), 1-0 | Busch Stadium II (3-3) | 45-78 | |
| » Starters: Bill Greif vs Alan Foster | Sixth | 31½ out |
| Tuesday, August 21 |
| » Lost to Phillies (58-66), 9-8 | Veteran's Stadium (0-4) | 45-79 | Lost 2 |
| » Starters: Randy Jones vs Ken Brett | Sixth | 31½ out |
| Wednesday, August 22 |
| » Defeated Phillies (58-67), 8-3 | Veteran's Stadium (1-4) | 46-79 | |
| » Starters: Steve Arlin vs Steve Carlton | Sixth | 30½ out |
| Thursday, August 23 |
| » Lost to Phillies (59-67), 6-3 | Veteran's Stadium (1-5) | 46-80 | |
| » Starters: Clay Kirby vs Jim Lonborg | Sixth | 31½ out |
| Friday, August 24 |
| » Defeated Expos (59-67), 5-3 | Parc Jarry (1-3) | 47-80 | |
| » Starters: Rich Troedson vs Balor Moore | Sixth | 31½ out |
| Saturday, August 25 |
| » Lost to Expos (60-67), 13-3 | Parc Jarry (1-4) | 47-81 | |
| » Starters: Bill Greif vs Mike Torrez | Sixth | 32½ out |
| Sunday, August 26 |
| » Defeated Expos (60-68), 4-2 | Parc Jarry (2-4) | 48-81 | |
| » Starters: Randy Jones vs Steve Renko | Sixth | 32½ out |
| Monday, August 27 |
| » Lost to Mets (59-70), 6-5 | Shea Stadium (0-4) | 48-82 | |
| » Starters: Steve Arlin vs George Stone | Sixth | 32½ out |
| Tuesday, August 28 |
| » Lost to Mets (60-70), 8-6 | Shea Stadium (0-5) | 48-83 | Lost 2 |
| » Starters: Clay Kirby vs Jon Matlack | Sixth | 33½ out |
| Wednesday, August 29 |
| » Lost to Mets (61-70), 3-0 | Shea Stadium (0-6) | 48-84 | Lost 3 |
| » Starters: Rich Troedson vs Jerry Koosman | Sixth | 33½ out |
| Friday, August 31 |
| » Lost to Reds (80-55), 10-4 | San Diego/Jack Murphy Stadium (28-40) | 48-85 | Lost 4 |
| » Starters: Don Gullett vs Bill Greif | Sixth | 34 out |
| » Major-league debuts: Ed Armbrister (Reds) |
| Saturday, September 1 |
| » Lost to Reds (81-55), 3-2 | San Diego/Jack Murphy Stadium (28-41) | 48-86 | Lost 5 |
| » Starters: Fred Norman vs Randy Jones | Sixth | 34 out |
| Sunday, September 2 |
| » Lost to Reds (82-55), 6-1 | San Diego/Jack Murphy Stadium (28-42) | 48-87 | Lost 6 |
| » Starters: Ross Grimsley vs Steve Arlin | Sixth | 34 out |
| Monday, September 3 |
| » Lost to Braves (66-73), 7-3 | San Diego/Jack Murphy Stadium (28-43) | 48-88 | Lost 7 |
| » Starters: Max Leon vs Clay Kirby | Fifth | 34 out |
| Tuesday, September 4 |
| » Lost to Braves (67-73), 3-0 | San Diego/Jack Murphy Stadium (28-44) | 48-89 | Lost 8 |
| » Starters: Roric Harrison vs Rich Troedson | Sixth | 35 out |
| Wednesday, September 5 |
| » Defeated Braves (67-74), 4-3 | San Diego/Jack Murphy Stadium (29-44) | 49-89 | |
| » Starters: Phil Niekro vs Bill Greif | Sixth | 35 out |
| Thursday, September 6 |
| » Defeated Dodgers (83-58), 3-2 | Dodger Stadium (5-1) | 50-89 | Won 2 |
| » Starters: Randy Jones vs Don Sutton | Sixth | 34½ out |
| Friday, September 7 |
| » Defeated Dodgers (83-59), 4-3 | Dodger Stadium (6-1) | 51-89 | Won 3 |
| » Starters: Steve Arlin vs Claude Osteen | Sixth | 33½ out |
| Future Padre David Newhan is born in Fullerton, CA. |
| Saturday, September 8 |
| » Defeated Dodgers (83-60), 9-6 | Dodger Stadium (7-1) | 52-89 | Won 4 |
| » Starters: Clay Kirby vs Tommy John | Sixth | 32½ out |
| Sunday, September 9 |
| » Lost to Dodgers (84-60), 5-3 | Dodger Stadium (7-2) | 52-90 | |
| » Starters: Rich Troedson vs Andy Messersmith | Sixth | 34 out |
| Monday, September 10 |
| » Defeated Astros (73-73), 5-3 | San Diego/Jack Murphy Stadium (30-44) | 53-90 | |
| » Starters: Tom Griffin vs Bill Greif | Sixth | 33½ out |
| Tuesday, September 11 |
| » Lost to Astros (74-73), 4-2 | San Diego/Jack Murphy Stadium (30-45) | 53-91 | |
| » Starters: Doug Konieczny vs Randy Jones | Sixth | 34½ out |
| » Major-league debuts: Doug Konieczny (Astros) |
| Future Padre Tom Davey is born in Garden City, MI. |
| Thursday, September 13 |
| » Lost to Giants (81-64), 8-6 | San Diego/Jack Murphy Stadium (30-46) | 53-92 | Lost 2 |
| » Starters: Jim Barr vs Steve Arlin | Sixth | 35½ out |
| Friday, September 14 |
| » Defeated Giants (81-65), 4-3 | San Diego/Jack Murphy Stadium (31-46) | 54-92 | |
| » Starters: Juan Marichal vs Clay Kirby | Sixth | 35½ out |
| Saturday, September 15 |
| » Lost to Giants (82-65), 5-2 | San Diego/Jack Murphy Stadium (31-47) | 54-93 | |
| » Starters: Tom Bradley vs Rich Troedson | Sixth | 36½ out |
| Sunday, September 16 |
| » Lost to Giants (83-65), 9-4 | San Diego/Jack Murphy Stadium (31-48) | 54-94 | Lost 2 |
| » Starters: Ron Bryant vs Bill Greif | Sixth | 37½ out |
| Future Padre Desi Relaford is born in Valdosta, GA. |
| Monday, September 17 |
| » Lost to Braves (73-79), 7-0 | Atlanta-Fulton County Stadium (2-6) | 54-95 | Lost 3 |
| » Starters: Randy Jones vs Carl Morton | Sixth | 37½ out |
| Tuesday, September 18 |
| » Defeated Braves (73-80), 9-4 | Atlanta-Fulton County Stadium (3-6) | 55-95 | |
| » Starters: Steve Arlin vs Roric Harrison | Sixth | 37½ out |
| Wednesday, September 19 |
| » Lost to Astros (78-76), 8-5 | Astrodome (2-6) | 55-96 | |
| » Starters: Clay Kirby vs Tom Griffin | Sixth | 38 out |
| » Defeated Astros (78-77), 6-3 | Astrodome (3-6) | 56-96 | |
| » Starters: Rich Troedson vs Doug Konieczny | Sixth | 38 out |
| Friday, September 21 |
| » Defeated Giants (84-69), 3-1 | Candlestick Park (2-4) | 57-96 | Won 2 |
| » Starters: Bill Greif vs Jim Barr | Sixth | 38 out |
| » Lost to Giants (85-69), 7-2 | Candlestick Park (2-5) | 57-97 | |
| » Starters: Randy Jones vs John D'Acquisto | Sixth | 38 out |
| Saturday, September 22 |
| » Lost to Giants (86-69), 5-2 | Candlestick Park (2-6) | 57-98 | Lost 2 |
| » Starters: Steve Arlin vs Juan Marichal | Sixth | 39 out |
| Sunday, September 23 |
| » Defeated Giants (86-70), 11-9 | Candlestick Park (3-6) | 58-98 | |
| » Starters: Clay Kirby vs Tom Bradley | Sixth | 38 out |
| Monday, September 24 |
| » Lost to Reds (97-60), 2-1 | Riverfront Stadium (2-5) | 58-99 | |
| » Starters: Rich Troedson vs Dick Baney | Sixth | 39 out |
| Tuesday, September 25 |
| » Lost to Reds (98-60), 3-2 | Riverfront Stadium (2-6) | 58-100 | Lost 2 |
| » Starters: Bill Greif vs Jack Billingham | Sixth | 40 out |
| Wednesday, September 26 |
| » Defeated Reds (98-61), 5-1 | Riverfront Stadium (3-6) | 59-100 | |
| » Starters: Randy Jones vs Ross Grimsley | Sixth | 39 out |
| Friday, September 28 |
| » Lost to Dodgers (94-66), 5-2 | San Diego/Jack Murphy Stadium (31-49) | 59-101 | |
| » Starters: Tommy John vs Mike Corkins | Sixth | 39 out |
| Saturday, September 29 |
| » Lost to Dodgers (95-66), 3-2 | San Diego/Jack Murphy Stadium (31-50) | 59-102 | Lost 2 |
| » Starters: Geoff Zahn vs Clay Kirby | Sixth | 40 out |
| Monday, October 1 |
| » Defeated Pirates (80-82), 4-3 | Three Rivers Stadium (2-4) | 60-102 | |
| » Starters: Randy Jones vs Bruce Kison | Sixth | 39 out |
| Tuesday, November 6 |
| Future Padre Carlos Almanzar is born in Santiago, D.R. |
| Wednesday, November 14 |
| Future Padre Ruben Rivera is born in Chorrera, Panama. |
| Tuesday, November 20 |
| Future Padre Brandon Kolb is born in Oakland, CA. |
| Wednesday, November 21 |
| Future Padre Todd Erdos is born in Washington, PA. |
Game information provided by Retrosheet (www.retrosheet.org) |