| Thursday, April 5 |
| » Major-league debuts: Gene Locklear (Reds) |
| Friday, April 6 |
| » Defeated Brewers (0-1), 10-0 | Memorial Stadium (1-0) | 1-0 | |
| » Starters: Bill Parsons vs Dave McNally | First | -- |
| » Major-league debuts: Pedro Garcia and Gorman Thomas (Brewers) |
| Saturday, April 7 |
| » Defeated Brewers (0-2), 8-7 | Memorial Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Skip Lockwood vs Mike Cuellar | First | -- |
| Wednesday, April 11 |
| » Defeated Tigers (1-2), 3-1 | Tiger Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Jim Palmer vs Woodie Fryman | First | -- |
| Thursday, April 12 |
| » Defeated Tigers (1-3), 1-0 | Tiger Stadium (2-0) | 4-0 | Won 4 |
| » Starters: Dave McNally vs Mickey Lolich | First | -- |
| Friday, April 13 |
| » Lost to Brewers (1-2), 2-0 | County Stadium (0-1) | 4-1 | |
| » Starters: Mike Cuellar vs Bill Parsons | Second | 1 out |
| Saturday, April 14 |
| » Defeated Brewers (1-3), 5-1 | County Stadium (1-1) | 5-1 | |
| » Starters: Doyle Alexander vs Skip Lockwood | Second | 1 out |
| Sunday, April 15 |
| » Lost to Brewers (2-3), 3-2 | County Stadium (1-2) | 5-2 | |
| » Starters: Jim Palmer vs Jim Slaton | Second | 1½ out |
| » Defeated Brewers (2-4), 5-4 | County Stadium (2-2) | 6-2 | |
| » Starters: Orlando Pena vs Gary Ryerson | Second | 1½ out |
| » Major-league debuts: Bob Coluccio (Brewers) |
| Tuesday, April 17 |
| » Defeated Yankees (3-6), 4-2 | Memorial Stadium (3-0) | 7-2 | Won 2 |
| » Starters: Steve Kline vs Dave McNally | First | -- |
| Wednesday, April 18 |
| » Lost to Yankees (4-6), 7-4 | Memorial Stadium (3-1) | 7-3 | |
| » Starters: Doc Medich vs Mike Cuellar | First | -- |
| Thursday, April 19 |
| » Lost to Yankees (5-6), 6-1 | Memorial Stadium (3-2) | 7-4 | Lost 2 |
| » Starters: Fritz Peterson vs Jim Palmer | First | -- |
| Future Oriole Willis Otanez is born in Vega Baja, P.R. |
| Friday, April 20 |
| » Defeated Tigers (7-5), 6-5 | Memorial Stadium (4-2) | 8-4 | |
| » Starters: Mickey Lolich vs Doyle Alexander | First | -- |
| Saturday, April 21 |
| » Lost to Tigers (8-5), 3-1 | Memorial Stadium (4-3) | 8-5 | |
| » Starters: Joe Coleman vs Dave McNally | First | -- |
| Sunday, April 22 |
| » Defeated Tigers (8-6), 5-3 | Memorial Stadium (5-3) | 9-5 | |
| » Starters: Jim Perry vs Mike Cuellar | First | -- |
| Tuesday, April 24 |
| » Lost to Angels (7-6), 6-5 | Anaheim Stadium (0-1) | 9-6 | |
| » Starters: Doyle Alexander vs Clyde Wright | First | -- |
| Wednesday, April 25 |
| » Lost to Angels (8-6), 1-0 | Anaheim Stadium (0-2) | 9-7 | Lost 2 |
| » Starters: Dave McNally vs Bill Singer | First | -- |
| Friday, April 27 |
| » Lost to Athletics (8-10), 4-3 | Oakland-Alameda County Stadium (0-1) | 9-8 | Lost 3 |
| » Starters: Mike Cuellar vs Blue Moon Odom | First | -- |
| Saturday, April 28 |
| » Defeated Athletics (8-11), 2-1 | Oakland-Alameda County Stadium (1-1) | 10-8 | |
| » Starters: Jim Palmer vs Ken Holtzman | First | -- |
| Sunday, April 29 |
| » Lost to Athletics (9-11), 4-3 | Oakland-Alameda County Stadium (1-2) | 10-9 | |
| » Starters: Dave McNally vs Catfish Hunter | First | -- |
| Tuesday, May 1 |
| » Lost to White Sox (11-5), 6-5 | Comiskey Park I (0-1) | 10-10 | Lost 2 |
| » Starters: Mike Cuellar vs Eddie Fisher | Second | ½ out |
| Wednesday, May 2 |
| » Lost to White Sox (12-5), 4-0 | Comiskey Park I (0-2) | 10-11 | Lost 3 |
| » Starters: Jim Palmer vs Wilbur Wood | Second | ½ out |
| Friday, May 4 |
| » Lost to Angels (12-8), 1-0 | Memorial Stadium (5-4) | 10-12 | Lost 4 |
| » Starters: Rudy May vs Dave McNally | Third | ½ out |
| Saturday, May 5 |
| » Lost to Angels (13-8), 3-1 | Memorial Stadium (5-5) | 10-13 | Lost 5 |
| » Starters: Bill Singer vs Mike Cuellar | Fourth | 1½ out |
| Sunday, May 6 |
| » Defeated Angels (13-9), 5-0 | Memorial Stadium (6-5) | 11-13 | |
| » Starters: Nolan Ryan vs Jim Palmer | Third | ½ out |
| Future Oriole Mike Kinkade is born in Livonia, MI. |
| Monday, May 7 |
| » Defeated Athletics (13-14), 8-2 | Memorial Stadium (7-5) | 12-13 | Won 2 |
| » Starters: Rollie Fingers vs Doyle Alexander | First | -- |
| Tuesday, May 8 |
| Former Oriole Ralph Miller dies in Cincinnati, OH at the age of 101. |
| Wednesday, May 9 |
| » Lost to Athletics (14-14), 4-3 | Memorial Stadium (7-6) | 12-14 | |
| » Starters: Catfish Hunter vs Dave McNally | Fourth | ½ out |
| Friday, May 11 |
| » Defeated Yankees (12-15), 3-0 | Yankee Stadium (1-0) | 13-14 | |
| » Starters: Jim Palmer vs Steve Kline | Second | 1 out |
| Saturday, May 12 |
| » Lost to Yankees (13-15), 8-0 | Yankee Stadium (1-1) | 13-15 | |
| » Starters: Mike Cuellar vs Doc Medich | Third | ½ out |
| Sunday, May 13 |
| » Lost to Yankees (14-15), 4-0 | Yankee Stadium (1-2) | 13-16 | Lost 2 |
| » Starters: Orlando Pena vs Mel Stottlemyre | Second | 1 out |
| » Defeated Yankees (14-16), 9-6 | Yankee Stadium (2-2) | 14-16 | |
| » Starters: Dave McNally vs Mike Kekich | Second | 1 out |
| Monday, May 14 |
| » Lost to Red Sox (14-15), 1-0 | Fenway Park (0-1) | 14-17 | |
| » Starters: Doyle Alexander vs Bill Lee | Fourth | 1 out |
| Thursday, May 17 |
| » Defeated Indians (15-20), 4-1 | Cleveland Stadium (1-0) | 15-17 | |
| » Starters: Jim Palmer vs Gaylord Perry | Third | 1 out |
| Friday, May 18 |
| » Defeated Indians (15-21), 6-2 | Cleveland Stadium (2-0) | 16-17 | Won 2 |
| » Starters: Mike Cuellar vs Dick Tidrow | Second | 1 out |
| Saturday, May 19 |
| » Defeated Red Sox (14-19), 3-1 | Memorial Stadium (8-6) | 17-17 | Won 3 |
| » Starters: Bill Lee vs Doyle Alexander | Second | 1 out |
| Monday, May 21 |
| » Lost to Red Sox (15-19), 4-1 | Memorial Stadium (8-7) | 17-18 | |
| » Starters: Luis Tiant vs Jim Palmer | Second | 1½ out |
| Future Oriole Tommy Davis is born in Mobile, AL. |
| Tuesday, May 22 |
| » Lost to Indians (18-23), 5-3 | Memorial Stadium (8-8) | 17-19 | Lost 2 |
| » Starters: Dick Tidrow vs Dave McNally | Fourth | 1½ out |
| Friday, May 25 |
| Future Oriole Mel Rosario is born in Santo Domingo, D.R. |
| Saturday, May 26 |
| » Defeated Twins (21-19), 7-2 | Metropolitan Stadium (1-0) | 18-19 | |
| » Starters: Mike Cuellar vs Dick Woodson | Third | 3 out |
| Monday, May 28 |
| » Lost to Twins (22-19), 10-3 | Metropolitan Stadium (1-1) | 18-20 | |
| » Starters: Doyle Alexander vs Jim Kaat | Third | 3 out |
| Tuesday, May 29 |
| » Defeated Royals (26-22), 3-2 | Royals Stadium (1-0) | 19-20 | |
| » Starters: Jim Palmer vs Paul Splittorff | Third | 2½ out |
| Wednesday, May 30 |
| » Defeated Royals (26-23), 5-4 | Royals Stadium (2-0) | 20-20 | Won 2 |
| » Starters: Dave McNally vs Wayne Simpson | Third | 2½ out |
| Thursday, May 31 |
| » Lost to Royals (27-23), 4-1 | Royals Stadium (2-1) | 20-21 | |
| » Starters: Mike Cuellar vs Gene Garber | Third | 2½ out |
| Friday, June 1 |
| » Lost to Rangers (16-28), 4-3 | Arlington Stadium (0-1) | 20-22 | Lost 2 |
| » Starters: Doyle Alexander vs Jim Merritt | Fourth | 3½ out |
| Saturday, June 2 |
| » Defeated Rangers (16-29), 8-3 | Arlington Stadium (1-1) | 21-22 | |
| » Starters: Jim Palmer vs Lloyd Allen | Third | 2½ out |
| Sunday, June 3 |
| » Defeated Rangers (16-30), 7-1 | Arlington Stadium (2-1) | 22-22 | Won 2 |
| » Starters: Dave McNally vs Pete Broberg | Third | 2½ out |
| Tuesday, June 5 |
| » Defeated White Sox (27-19), 7-4 | Memorial Stadium (9-8) | 23-22 | Won 3 |
| » Starters: Wilbur Wood vs Mike Cuellar | Third | 2½ out |
| Wednesday, June 6 |
| » Defeated White Sox (27-20), 14-4 | Memorial Stadium (10-8) | 24-22 | Won 4 |
| » Starters: Eddie Fisher vs Doyle Alexander | Third | 2½ out |
| Thursday, June 7 |
| » Lost to White Sox (28-20), 3-2 | Memorial Stadium (10-9) | 24-23 | |
| » Starters: Steve Stone vs Jim Palmer | Third | 2½ out |
| Friday, June 8 |
| » Lost to Twins (29-21), 2-0 | Memorial Stadium (10-10) | 24-24 | Lost 2 |
| » Starters: Bert Blyleven vs Dave McNally | Third | 2½ out |
| Saturday, June 9 |
| » Defeated Twins (29-22), 7-4 | Memorial Stadium (11-10) | 25-24 | |
| » Starters: Bill Hands vs Mike Cuellar | Third | 3 out |
| Sunday, June 10 |
| » Lost to Twins (30-22), 11-4 | Memorial Stadium (11-11) | 25-25 | |
| » Starters: Dick Woodson vs Doyle Alexander | Third | 3 out |
| Tuesday, June 12 |
| » Defeated Royals (31-29), 6-4 | Memorial Stadium (12-11) | 26-25 | |
| » Starters: Steve Busby vs Jim Palmer | Fourth | 2½ out |
| » Major-league debuts: Frank White (Royals) |
| Wednesday, June 13 |
| » Lost to Royals (32-29), 2-0 | Memorial Stadium (12-12) | 26-26 | |
| » Starters: Dick Drago vs Dave McNally | Third | 3 out |
| Thursday, June 14 |
| » Defeated Royals (32-30), 8-3 | Memorial Stadium (13-12) | 27-26 | |
| » Starters: Mark Littell vs Doyle Alexander | Third | 2 out |
| » Major-league debuts: Mark Littell (Royals) |
| Friday, June 15 |
| » Defeated Rangers (19-36), 1-0 | Memorial Stadium (14-12) | 28-26 | Won 2 |
| » Starters: Sonny Siebert vs Mike Cuellar | Third | 2 out |
| Saturday, June 16 |
| » Defeated Rangers (19-37), 9-1 | Memorial Stadium (15-12) | 29-26 | Won 3 |
| » Starters: Steve Dunning vs Jim Palmer | Second | 2 out |
| Sunday, June 17 |
| » Defeated Rangers (19-38), 5-4 | Memorial Stadium (16-12) | 30-26 | Won 4 |
| » Starters: Jim Merritt vs Dave McNally | Second | 2 out |
| Tuesday, June 19 |
| » Lost to Yankees (34-30), 5-4 | Yankee Stadium (2-3) | 30-27 | |
| » Starters: Doyle Alexander vs Doc Medich | Third | 3 out |
| Wednesday, June 20 |
| » Lost to Yankees (35-30), 2-1 | Yankee Stadium (2-4) | 30-28 | Lost 2 |
| » Starters: Mike Cuellar vs Mel Stottlemyre | Third | 3½ out |
| Thursday, June 21 |
| » Defeated Red Sox (31-32), 6-3 | Fenway Park (1-1) | 31-28 | |
| » Starters: Jim Palmer vs Luis Tiant | Second | 3½ out |
| Saturday, June 23 |
| » Lost to Red Sox (32-32), 5-1 | Fenway Park (1-2) | 31-29 | |
| » Starters: Dave McNally vs Ray Culp | Third | 3½ out |
| » Defeated Red Sox (32-33), 2-1 | Fenway Park (2-2) | 32-29 | |
| » Starters: Jesse Jefferson vs Marty Pattin | Third | 3½ out |
| » Major-league debuts: Jesse Jefferson (Orioles) |
| Sunday, June 24 |
| » Lost to Red Sox (33-33), 1-0 | Fenway Park (2-3) | 32-30 | |
| » Starters: Doyle Alexander vs John Curtis | Third | 4 out |
| Monday, June 25 |
| » Defeated Brewers (37-32), 4-3 | County Stadium (3-2) | 33-30 | |
| » Starters: Mike Cuellar vs Jerry Bell | Third | 4 out |
| Tuesday, June 26 |
| » Defeated Brewers (37-33), 6-0 | County Stadium (4-2) | 34-30 | Won 2 |
| » Starters: Jim Palmer vs Jim Colborn | Second | 4 out |
| Wednesday, June 27 |
| » Defeated Yankees (41-32), 4-0 | Memorial Stadium (17-12) | 35-30 | Won 3 |
| » Starters: Fritz Peterson vs Dave McNally | Second | 4 out |
| Thursday, June 28 |
| » Defeated Yankees (41-33), 6-3 | Memorial Stadium (18-12) | 36-30 | Won 4 |
| » Starters: Sam McDowell vs Jesse Jefferson | Second | 4 out |
| Friday, June 29 |
| » Defeated Tigers (36-38), 9-2 | Tiger Stadium (3-0) | 37-30 | Won 5 |
| » Starters: Doyle Alexander vs Jim Perry | Second | 4 out |
| Saturday, June 30 |
| » Lost to Tigers (37-38), 4-1 | Tiger Stadium (3-1) | 37-31 | |
| » Starters: Mike Cuellar vs Mike Strahler | Second | 4 out |
| Sunday, July 1 |
| » Lost to Tigers (38-38), 5-3 | Tiger Stadium (3-2) | 37-32 | Lost 2 |
| » Starters: Jim Palmer vs Joe Coleman | Second | 4 out |
| » Lost to Tigers (39-38), 1-0 | Tiger Stadium (3-3) | 37-33 | Lost 3 |
| » Starters: Dave McNally vs Mickey Lolich | Second | 4 out |
| Monday, July 2 |
| » Lost to Brewers (39-37), 5-3 | Memorial Stadium (18-13) | 37-34 | Lost 4 |
| » Starters: Jerry Bell vs Jesse Jefferson | Second | 4 out |
| Tuesday, July 3 |
| » Defeated Brewers (39-38), 9-7 | Memorial Stadium (19-13) | 38-34 | |
| » Starters: Chris Short vs Doyle Alexander | Second | 3½ out |
| » Defeated Brewers (39-39), 6-4 | Memorial Stadium (20-13) | 39-34 | Won 2 |
| » Starters: Eduardo Rodriguez vs Bob Reynolds | Second | 3½ out |
| Wednesday, July 4 |
| » Defeated Brewers (39-40), 10-7 | Memorial Stadium (21-13) | 40-34 | Won 3 |
| » Starters: Jim Slaton vs Mike Cuellar | Second | 4 out |
| Friday, July 6 |
| » Lost to Athletics (46-37), 7-5 | Memorial Stadium (21-14) | 40-35 | |
| » Starters: Catfish Hunter vs Jim Palmer | Second | 4 out |
| » Defeated Athletics (46-38), 5-3 | Memorial Stadium (22-14) | 41-35 | |
| » Starters: Vida Blue vs Dave McNally | Second | 4 out |
| Saturday, July 7 |
| » Lost to Athletics (47-38), 5-4 | Memorial Stadium (22-15) | 41-36 | |
| » Starters: Ken Holtzman vs Mike Cuellar | Third | 4½ out |
| Sunday, July 8 |
| » Lost to Athletics (48-38), 6-5 | Memorial Stadium (22-16) | 41-37 | Lost 2 |
| » Starters: Dave Hamilton vs Jesse Jefferson | Third | 4½ out |
| Monday, July 9 |
| » Defeated Angels (44-39), 5-3 | Memorial Stadium (23-16) | 42-37 | |
| » Starters: Clyde Wright vs Dave McNally | Third | 4½ out |
| Tuesday, July 10 |
| » Lost to Angels (45-39), 10-8 | Memorial Stadium (23-17) | 42-38 | |
| » Starters: Rudy May vs Jim Palmer | Third | 1½ out |
| Wednesday, July 11 |
| » Defeated Angels (45-40), 7-1 | Memorial Stadium (24-17) | 43-38 | |
| » Starters: Nolan Ryan vs Mike Cuellar | Third | 4½ out |
| Thursday, July 12 |
| » Defeated White Sox (45-42), 4-3 | Comiskey Park I (1-2) | 44-38 | Won 2 |
| » Starters: Jesse Jefferson vs Bart Johnson | Third | 4½ out |
| Friday, July 13 |
| » Lost to White Sox (46-42), 3-2 | Comiskey Park I (1-3) | 44-39 | |
| » Starters: Dave McNally vs Wilbur Wood | Third | 4½ out |
| Saturday, July 14 |
| » Defeated White Sox (46-43), 5-4 | Comiskey Park I (2-3) | 45-39 | |
| » Starters: Jim Palmer vs Stan Bahnsen | Third | 4½ out |
| Sunday, July 15 |
| » Defeated White Sox (46-44), 3-2 | Comiskey Park I (3-3) | 46-39 | Won 2 |
| » Starters: Mike Cuellar vs Steve Stone | Third | 4½ out |
| Monday, July 16 |
| » Defeated Athletics (52-41), 7-5 | Oakland-Alameda County Stadium (2-2) | 47-39 | Won 3 |
| » Starters: Jesse Jefferson vs Catfish Hunter | Third | 4 out |
| » Major-league debuts: Don Hood (Orioles) |
| Tuesday, July 17 |
| » Lost to Athletics (53-41), 3-1 | Oakland-Alameda County Stadium (2-3) | 47-40 | |
| » Starters: Dave McNally vs Vida Blue | Second | 4½ out |
| Wednesday, July 18 |
| » Defeated Athletics (53-42), 5-2 | Oakland-Alameda County Stadium (3-3) | 48-40 | |
| » Starters: Jim Palmer vs Ken Holtzman | Second | 4½ out |
| Thursday, July 19 |
| » Defeated Angels (47-46), 3-1 | Anaheim Stadium (1-2) | 49-40 | Won 2 |
| » Starters: Mike Cuellar vs Nolan Ryan | Second | 4 out |
| Friday, July 20 |
| » Lost to Angels (48-46), 8-3 | Anaheim Stadium (1-3) | 49-41 | |
| » Starters: Jesse Jefferson vs Bill Singer | Second | 4½ out |
| Saturday, July 21 |
| » Defeated Angels (48-47), 5-3 | Anaheim Stadium (2-3) | 50-41 | |
| » Starters: Dave McNally vs Clyde Wright | Second | 4 out |
| Sunday, July 22 |
| » Defeated Angels (48-48), 8-2 | Anaheim Stadium (3-3) | 51-41 | Won 2 |
| » Starters: Jim Palmer vs Rudy May | Second | 4½ out |
| Thursday, July 26 |
| » Defeated Indians (35-64), 8-4 | Memorial Stadium (25-17) | 52-41 | Won 3 |
| » Starters: Gaylord Perry vs Dave McNally | Second | 4 out |
| » Lost to Indians (36-64), 6-4 | Memorial Stadium (25-18) | 52-42 | |
| » Starters: Dick Tidrow vs Mike Cuellar | Second | 4 out |
| Friday, July 27 |
| » Defeated Indians (36-65), 9-0 | Memorial Stadium (26-18) | 53-42 | |
| » Starters: Dick Bosman vs Jim Palmer | Second | 3½ out |
| » Defeated Indians (36-66), 5-2 | Memorial Stadium (27-18) | 54-42 | Won 2 |
| » Starters: Brent Strom vs Jesse Jefferson | Second | 3½ out |
| Saturday, July 28 |
| » Lost to Tigers (52-48), 3-2 | Memorial Stadium (27-19) | 54-43 | |
| » Starters: Joe Coleman vs Mike Cuellar | Second | 3½ out |
| Sunday, July 29 |
| » Lost to Tigers (53-48), 8-3 | Memorial Stadium (27-20) | 54-44 | Lost 2 |
| » Starters: Mike Strahler vs Don Hood | Second | 4 out |
| Monday, July 30 |
| » Lost to Tigers (54-48), 4-3 | Memorial Stadium (27-21) | 54-45 | Lost 3 |
| » Starters: Mickey Lolich vs Jesse Jefferson | Second | 4 out |
| Tuesday, July 31 |
| » Defeated Indians (38-68), 5-1 | Cleveland Stadium (3-0) | 55-45 | |
| » Starters: Jim Palmer vs Dick Tidrow | Second | 4 out |
| Wednesday, August 1 |
| » Defeated Indians (38-69), 4-2 | Cleveland Stadium (4-0) | 56-45 | Won 2 |
| » Starters: Mike Cuellar vs Dick Bosman | First | -- |
| Thursday, August 2 |
| » Lost to Indians (39-69), 6-0 | Cleveland Stadium (4-1) | 56-46 | |
| » Starters: Don Hood vs Gaylord Perry | First | -- |
| Friday, August 3 |
| » Lost to Red Sox (57-49), 8-5 | Memorial Stadium (27-22) | 56-47 | Lost 2 |
| » Starters: Luis Tiant vs Dave McNally | First | -- |
| » Defeated Red Sox (57-50), 8-2 | Memorial Stadium (28-22) | 57-47 | |
| » Starters: Dick Pole vs Jesse Jefferson | First | -- |
| » Major-league debuts: Dick Pole (Red Sox) |
| Saturday, August 4 |
| » Defeated Red Sox (57-51), 4-1 | Memorial Stadium (29-22) | 58-47 | Won 2 |
| » Starters: Bill Lee vs Jim Palmer | First | -- |
| Sunday, August 5 |
| » Lost to Red Sox (58-51), 7-4 | Memorial Stadium (29-23) | 58-48 | |
| » Starters: John Curtis vs Mike Cuellar | First | -- |
| Monday, August 6 |
| » Lost to Red Sox (59-51), 5-3 | Memorial Stadium (29-24) | 58-49 | Lost 2 |
| » Starters: Roger Moret vs Doyle Alexander | Second | 1½ out |
| Tuesday, August 7 |
| » Lost to Twins (56-53), 4-2 | Metropolitan Stadium (1-2) | 58-50 | Lost 3 |
| » Starters: Jesse Jefferson vs Joe Decker | Second | 1½ out |
| » Defeated Twins (56-54), 10-4 | Metropolitan Stadium (2-2) | 59-50 | |
| » Starters: Dave McNally vs Jim Kaat | Second | 1½ out |
| » Major-league debuts: Vic Albury (Twins) |
| Wednesday, August 8 |
| » Defeated Twins (56-55), 6-1 | Metropolitan Stadium (3-2) | 60-50 | Won 2 |
| » Starters: Jim Palmer vs Dick Woodson | Second | 1½ out |
| Thursday, August 9 |
| » Defeated Twins (56-56), 2-1 | Metropolitan Stadium (4-2) | 61-50 | Won 3 |
| » Starters: Mike Cuellar vs Bert Blyleven | First | -- |
| Friday, August 10 |
| » Lost to Royals (67-50), 2-1 | Royals Stadium (2-2) | 61-51 | |
| » Starters: Doyle Alexander vs Al Fitzmorris | Second | 1½ out |
| Saturday, August 11 |
| » Lost to Royals (68-50), 9-4 | Royals Stadium (2-3) | 61-52 | Lost 2 |
| » Starters: Dave McNally vs Paul Splittorff | Second | 1½ out |
| Sunday, August 12 |
| » Defeated Royals (68-51), 10-6 | Royals Stadium (3-3) | 62-52 | |
| » Starters: Jim Palmer vs Dick Drago | Second | 1½ out |
| Monday, August 13 |
| » Defeated Rangers (42-74), 7-4 | Arlington Stadium (3-1) | 63-52 | Won 2 |
| » Starters: Mike Cuellar vs Jim Merritt | Second | 1½ out |
| Tuesday, August 14 |
| » Defeated Rangers (42-75), 12-10 | Arlington Stadium (4-1) | 64-52 | Won 3 |
| » Starters: Doyle Alexander vs Sonny Siebert | Second | 1½ out |
| Wednesday, August 15 |
| » Defeated Rangers (42-76), 5-1 | Arlington Stadium (5-1) | 65-52 | Won 4 |
| » Starters: Dave McNally vs Jim Bibby | First | -- |
| Friday, August 17 |
| » Defeated White Sox (58-64), 3-2 | Memorial Stadium (30-24) | 66-52 | Won 5 |
| » Starters: Stan Bahnsen vs Jim Palmer | First | -- |
| Saturday, August 18 |
| » Defeated White Sox (58-65), 3-0 | Memorial Stadium (31-24) | 67-52 | Won 6 |
| » Starters: Terry Forster vs Mike Cuellar | First | -- |
| Sunday, August 19 |
| » Defeated White Sox (58-66), 8-2 | Memorial Stadium (32-24) | 68-52 | Won 7 |
| » Starters: Wilbur Wood vs Dave McNally | First | -- |
| Monday, August 20 |
| » Defeated Twins (59-64), 4-3 | Memorial Stadium (33-24) | 69-52 | Won 8 |
| » Starters: Ray Corbin vs Doyle Alexander | First | -- |
| Tuesday, August 21 |
| » Defeated Twins (59-65), 2-1 | Memorial Stadium (34-24) | 70-52 | Won 9 |
| » Starters: Bert Blyleven vs Jim Palmer | First | -- |
| Wednesday, August 22 |
| » Defeated Twins (59-66), 4-3 | Memorial Stadium (35-24) | 71-52 | Won 10 |
| » Starters: Bill Campbell vs Mike Cuellar | First | -- |
| Thursday, August 23 |
| Future Oriole Casey Blake is born in Des Moines, IA. |
| Friday, August 24 |
| » Defeated Royals (73-56), 6-0 | Memorial Stadium (36-24) | 72-52 | Won 11 |
| » Starters: Al Fitzmorris vs Dave McNally | First | -- |
| Saturday, August 25 |
| » Defeated Royals (73-57), 7-1 | Memorial Stadium (37-24) | 73-52 | Won 12 |
| » Starters: Steve Busby vs Doyle Alexander | First | -- |
| Sunday, August 26 |
| » Defeated Royals (73-58), 10-1 | Memorial Stadium (38-24) | 74-52 | Won 13 |
| » Starters: Paul Splittorff vs Jim Palmer | First | -- |
| Monday, August 27 |
| » Defeated Rangers (45-84), 6-1 | Memorial Stadium (39-24) | 75-52 | Won 14 |
| » Starters: David Clyde vs Mike Cuellar | First | -- |
| Tuesday, August 28 |
| » Lost to Rangers (46-84), 5-3 | Memorial Stadium (39-25) | 75-53 | |
| » Starters: Charlie Hudson vs Dave McNally | First | -- |
| Wednesday, August 29 |
| » Defeated Rangers (46-85), 6-1 | Memorial Stadium (40-25) | 76-53 | |
| » Starters: Don Durham vs Doyle Alexander | First | -- |
| Friday, August 31 |
| » Lost to Yankees (69-66), 5-2 | Yankee Stadium (2-5) | 76-54 | |
| » Starters: Jim Palmer vs Mel Stottlemyre | First | -- |
| Saturday, September 1 |
| » Defeated Yankees (69-67), 10-6 | Yankee Stadium (3-5) | 77-54 | |
| » Starters: Mike Cuellar vs Pat Dobson | First | -- |
| Sunday, September 2 |
| » Defeated Yankees (69-68), 1-0 | Yankee Stadium (4-5) | 78-54 | Won 2 |
| » Starters: Dave McNally vs Sam McDowell | First | -- |
| Monday, September 3 |
| » Defeated Red Sox (74-63), 13-8 | Fenway Park (3-3) | 79-54 | Won 3 |
| » Starters: Doyle Alexander vs John Curtis | First | -- |
| » Lost to Red Sox (75-63), 9-8 | Fenway Park (3-4) | 79-55 | |
| » Starters: Jesse Jefferson vs Dick Pole | First | -- |
| Tuesday, September 4 |
| » Lost to Red Sox (76-63), 2-1 | Fenway Park (3-5) | 79-56 | Lost 2 |
| » Starters: Jim Palmer vs Luis Tiant | First | -- |
| Wednesday, September 5 |
| » Lost to Red Sox (77-63), 7-5 | Fenway Park (3-6) | 79-57 | Lost 3 |
| » Starters: Mike Cuellar vs Roger Moret | First | -- |
| Friday, September 7 |
| » Defeated Indians (61-82), 7-3 | Cleveland Stadium (5-1) | 80-57 | |
| » Starters: Dave McNally vs Gaylord Perry | First | -- |
| Saturday, September 8 |
| » Defeated Indians (61-83), 6-1 | Cleveland Stadium (6-1) | 81-57 | Won 2 |
| » Starters: Jim Palmer vs Milt Wilcox | First | -- |
| Sunday, September 9 |
| » Lost to Indians (62-83), 6-4 | Cleveland Stadium (6-2) | 81-58 | |
| » Starters: Doyle Alexander vs Brent Strom | First | -- |
| » Defeated Indians (62-84), 13-4 | Cleveland Stadium (7-2) | 82-58 | |
| » Starters: Mike Cuellar vs Tom Timmermann | First | -- |
| » Major-league debuts: Doug DeCinces (Orioles) |
| Monday, September 10 |
| » Lost to Red Sox (79-65), 4-3 | Memorial Stadium (40-26) | 82-59 | |
| » Starters: Luis Tiant vs Jesse Jefferson | First | -- |
| Tuesday, September 11 |
| » Defeated Red Sox (79-66), 8-3 | Memorial Stadium (41-26) | 83-59 | |
| » Starters: Marty Pattin vs Dave McNally | First | -- |
| Wednesday, September 12 |
| » Defeated Brewers (70-75), 4-1 | Memorial Stadium (42-26) | 84-59 | Won 2 |
| » Starters: Skip Lockwood vs Jim Palmer | First | -- |
| » Defeated Brewers (70-76), 5-3 | Memorial Stadium (43-26) | 85-59 | Won 3 |
| » Starters: Jerry Bell vs Don Hood | First | -- |
| Thursday, September 13 |
| » Defeated Brewers (70-77), 7-6 | Memorial Stadium (44-26) | 86-59 | Won 4 |
| » Starters: Bill Champion vs Mike Cuellar | First | -- |
| » Major-league debuts: Wayne Garland (Orioles) |
| Saturday, September 15 |
| » Lost to Yankees (74-74), 3-0 | Memorial Stadium (44-27) | 86-60 | |
| » Starters: Mel Stottlemyre vs Dave McNally | First | -- |
| Sunday, September 16 |
| » Defeated Yankees (74-75), 3-0 | Memorial Stadium (45-27) | 87-60 | |
| » Starters: Fritz Peterson vs Jim Palmer | First | -- |
| » Lost to Yankees (75-75), 7-5 | Memorial Stadium (45-28) | 87-61 | |
| » Starters: Pat Dobson vs Doyle Alexander | First | -- |
| Monday, September 17 |
| » Defeated Yankees (75-76), 5-4 | Memorial Stadium (46-28) | 88-61 | |
| » Starters: Lindy McDaniel vs Mike Cuellar | First | -- |
| Tuesday, September 18 |
| » Defeated Tigers (79-71), 6-2 | Tiger Stadium (4-3) | 89-61 | Won 2 |
| » Starters: Jesse Jefferson vs Mickey Lolich | First | -- |
| Wednesday, September 19 |
| » Lost to Tigers (80-71), 10-1 | Tiger Stadium (4-4) | 89-62 | |
| » Starters: Dave McNally vs Joe Coleman | First | -- |
| Thursday, September 20 |
| » Defeated Tigers (80-72), 9-0 | Tiger Stadium (5-4) | 90-62 | |
| » Starters: Jim Palmer vs Woodie Fryman | First | -- |
| » Major-league debuts: Gary Ignasiak (Tigers) |
| Friday, September 21 |
| » Defeated Brewers (72-81), 7-4 | County Stadium (5-2) | 91-62 | Won 2 |
| » Starters: Mike Cuellar vs Bill Champion | First | -- |
| Saturday, September 22 |
| » Defeated Brewers (72-82), 7-1 | County Stadium (6-2) | 92-62 | Won 3 |
| » Starters: Doyle Alexander vs Jim Colborn | First | -- |
| Sunday, September 23 |
| » Defeated Brewers (72-83), 2-1 | County Stadium (7-2) | 93-62 | Won 4 |
| » Starters: Dave McNally vs Jim Slaton | First | -- |
| Monday, September 24 |
| Future Oriole Jesse Garcia is born in Corpus Christi, TX. |
| Tuesday, September 25 |
| » Defeated Tigers (83-74), 8-3 | Memorial Stadium (47-28) | 94-62 | Won 5 |
| » Starters: Jim Perry vs Jesse Jefferson | First | -- |
| Wednesday, September 26 |
| » Defeated Tigers (83-75), 4-0 | Memorial Stadium (48-28) | 95-62 | Won 6 |
| » Starters: Mickey Lolich vs Don Hood | First | -- |
| Thursday, September 27 |
| » Lost to Tigers (84-75), 5-2 | Memorial Stadium (48-29) | 95-63 | |
| » Starters: Joe Coleman vs Wayne Garland | First | -- |
| Friday, September 28 |
| » Lost to Indians (70-89), 6-4 | Memorial Stadium (48-30) | 95-64 | Lost 2 |
| » Starters: Dick Tidrow vs Jim Palmer | First | -- |
| » Defeated Indians |
