| Tuesday, January 9 |
| Former Indian Lyn Lary dies in Downey, CA at the age of 67. |
| Sunday, January 28 |
| Future Indian Jacob Cruz is born in Oxnard, CA. |
| Thursday, February 8 |
| Former Indian Roy Spencer dies in Port Charlotte, FL at the age of 73. |
| Thursday, April 5 |
| » Major-league debuts: Gene Locklear (Reds) |
| Former Indian Tex Jeanes dies in Longview, TX at the age of 73. |
| Saturday, April 7 |
| » Defeated Tigers (0-1), 2-1 | Cleveland Stadium (1-0) | 1-0 | |
| » Starters: Mickey Lolich vs Gaylord Perry | Second | ½ out |
| Sunday, April 8 |
| » Lost to Tigers (1-1), 4-0 | Cleveland Stadium (1-1) | 1-1 | |
| » Starters: Joe Coleman vs Dick Tidrow | Third | 1½ out |
| Monday, April 9 |
| » Defeated Yankees (0-4), 3-1 | Yankee Stadium (1-0) | 2-1 | |
| » Starters: Brent Strom vs Fritz Peterson | Third | 1 out |
| Wednesday, April 11 |
| » Lost to Yankees (1-4), 4-0 | Yankee Stadium (1-1) | 2-2 | |
| » Starters: Gaylord Perry vs Mel Stottlemyre | Second | 1½ out |
| Thursday, April 12 |
| » Lost to Yankees (2-4), 5-0 | Yankee Stadium (1-2) | 2-3 | Lost 2 |
| » Starters: Dick Tidrow vs Steve Kline | Third | 2½ out |
| Friday, April 13 |
| » Lost to Tigers (2-3), 4-3 | Tiger Stadium (0-1) | 2-4 | Lost 3 |
| » Starters: Brent Strom vs Joe Coleman | Fifth | 2½ out |
| Saturday, April 14 |
| » Lost to Tigers (3-3), 8-2 | Tiger Stadium (0-2) | 2-5 | Lost 4 |
| » Starters: Steve Dunning vs Jim Perry | Fourth | 3½ out |
| Sunday, April 15 |
| » Defeated Tigers (3-4), 7-0 | Tiger Stadium (1-2) | 3-5 | |
| » Starters: Gaylord Perry vs Tom Timmermann | Fourth | 2½ out |
| » Major-league debuts: Dave Lemanczyk (Tigers) |
| Tuesday, April 17 |
| » Defeated Brewers (2-5), 7-3 | Cleveland Stadium (2-1) | 4-5 | Won 2 |
| » Starters: Bill Parsons vs Dick Tidrow | Fourth | 3 out |
| Wednesday, April 18 |
| » Lost to Brewers (3-5), 4-0 | Cleveland Stadium (2-2) | 4-6 | |
| » Starters: Skip Lockwood vs Brent Strom | Fourth | 3 out |
| Thursday, April 19 |
| » Lost to Brewers (4-5), 10-7 | Cleveland Stadium (2-3) | 4-7 | Lost 2 |
| » Starters: Jerry Bell vs Steve Dunning | Fourth | 3 out |
| Friday, April 20 |
| » Defeated Red Sox (4-6), 3-2 | Cleveland Stadium (3-3) | 5-7 | |
| » Starters: Marty Pattin vs Gaylord Perry | Fourth | 3 out |
| Saturday, April 21 |
| » Lost to Red Sox (5-6), 11-5 | Cleveland Stadium (3-4) | 5-8 | |
| » Starters: Lynn McGlothen vs Dick Tidrow | Fifth | 3 out |
| Sunday, April 22 |
| » Defeated Red Sox (5-7), 8-7 | Cleveland Stadium (4-4) | 6-8 | |
| » Starters: Luis Tiant vs Brent Strom | Fifth | 3½ out |
| » Lost to Red Sox (6-7), 5-2 | Cleveland Stadium (4-5) | 6-9 | |
| » Starters: Roger Moret vs Steve Dunning | Fifth | 3½ out |
| Tuesday, April 24 |
| » Lost to Athletics (6-9), 4-0 | Oakland-Alameda County Stadium (0-1) | 6-10 | Lost 2 |
| » Starters: Gaylord Perry vs Ken Holtzman | Sixth | 3½ out |
| Wednesday, April 25 |
| » Defeated Athletics (6-10), 1-0 | Oakland-Alameda County Stadium (1-1) | 7-10 | |
| » Starters: Dick Tidrow vs Rollie Fingers | Fifth | 2½ out |
| Thursday, April 26 |
| » Lost to Athletics (7-10), 3-2 | Oakland-Alameda County Stadium (1-2) | 7-11 | |
| » Starters: Brent Strom vs Catfish Hunter | Fifth | 3 out |
| Friday, April 27 |
| » Defeated Angels (8-7), 6-2 | Anaheim Stadium (1-0) | 8-11 | |
| » Starters: Milt Wilcox vs Nolan Ryan | Fifth | 2 out |
| Saturday, April 28 |
| » Lost to Angels (9-7), 5-0 | Anaheim Stadium (1-1) | 8-12 | |
| » Starters: Gaylord Perry vs Rudy May | Sixth | 3 out |
| Sunday, April 29 |
| » Defeated Angels (9-8), 3-2 | Anaheim Stadium (2-1) | 9-12 | |
| » Starters: Dick Tidrow vs Clyde Wright | Fifth | 2 out |
| Wednesday, May 2 |
| » Defeated Twins (9-9), 8-4 | Metropolitan Stadium (1-0) | 10-12 | Won 2 |
| » Starters: Brent Strom vs Dick Woodson | Third | 1 out |
| Friday, May 4 |
| » Lost to Athletics (11-12), 11-4 | Cleveland Stadium (4-6) | 10-13 | |
| » Starters: Catfish Hunter vs Gaylord Perry | Fourth | 1 out |
| Saturday, May 5 |
| » Defeated Athletics (11-13), 6-5 | Cleveland Stadium (5-6) | 11-13 | |
| » Starters: Blue Moon Odom vs Milt Wilcox | Second | 1 out |
| Sunday, May 6 |
| » Lost to Athletics (12-13), 12-0 | Cleveland Stadium (5-7) | 11-14 | |
| » Starters: Ken Holtzman vs Dick Tidrow | Fourth | 1½ out |
| » Lost to Athletics (13-13), 7-3 | Cleveland Stadium (5-8) | 11-15 | Lost 2 |
| » Starters: Vida Blue vs Brent Strom | Fourth | 1½ out |
| Tuesday, May 8 |
| » Defeated Angels (13-10), 2-0 | Cleveland Stadium (6-8) | 12-15 | |
| » Starters: Clyde Wright vs Gaylord Perry | Fourth | 1 out |
| Wednesday, May 9 |
| » Defeated Angels (13-11), 10-3 | Cleveland Stadium (7-8) | 13-15 | Won 2 |
| » Starters: Rudy May vs Milt Wilcox | Third | ½ out |
| Thursday, May 10 |
| » Lost to Red Sox (11-14), 4-3 | Fenway Park (0-1) | 13-16 | |
| » Starters: Dick Tidrow vs Bill Lee | Fourth | 2 out |
| Friday, May 11 |
| » Lost to Red Sox (12-14), 4-2 | Fenway Park (0-2) | 13-17 | Lost 2 |
| » Starters: Brent Strom vs Luis Tiant | Fifth | 1½ out |
| Saturday, May 12 |
| » Defeated Red Sox (12-15), 10-2 | Fenway Park (1-2) | 14-17 | |
| » Starters: Gaylord Perry vs John Curtis | Fourth | 2 out |
| Sunday, May 13 |
| » Lost to Red Sox (13-15), 8-3 | Fenway Park (1-3) | 14-18 | |
| » Starters: Milt Wilcox vs Marty Pattin | Fifth | 2 out |
| Monday, May 14 |
| » Defeated Brewers (14-15), 2-1 | County Stadium (1-0) | 15-18 | |
| » Starters: Dick Tidrow vs Bill Champion | Third | 2 out |
| Tuesday, May 15 |
| » Lost to Brewers (15-15), 2-1 | County Stadium (1-1) | 15-19 | |
| » Starters: Dick Bosman vs Jerry Bell | Fifth | 2 out |
| Thursday, May 17 |
| » Lost to Orioles (15-17), 4-1 | Cleveland Stadium (7-9) | 15-20 | Lost 2 |
| » Starters: Jim Palmer vs Gaylord Perry | Fifth | 2½ out |
| Friday, May 18 |
| » Lost to Orioles (16-17), 6-2 | Cleveland Stadium (7-10) | 15-21 | Lost 3 |
| » Starters: Mike Cuellar vs Dick Tidrow | Fifth | 3½ out |
| Saturday, May 19 |
| » Defeated Yankees (16-19), 6-4 | Cleveland Stadium (8-10) | 16-21 | |
| » Starters: Fritz Peterson vs Milt Wilcox | Fifth | 3½ out |
| Former Indian Jim Moore dies in Seattle, WA at the age of 70. |
| Sunday, May 20 |
| » Lost to Yankees (17-19), 4-2 | Cleveland Stadium (8-11) | 16-22 | |
| » Starters: Fred Beene vs Dick Bosman | Sixth | 4½ out |
| » Lost to Yankees (18-19), 7-3 | Cleveland Stadium (8-12) | 16-23 | Lost 2 |
| » Starters: Mike Kekich vs Brent Strom | Sixth | 4½ out |
| Monday, May 21 |
| » Defeated Yankees (18-20), 10-5 | Cleveland Stadium (9-12) | 17-23 | |
| » Starters: Doc Medich vs Gaylord Perry | Sixth | 4 out |
| Tuesday, May 22 |
| » Defeated Orioles (17-19), 5-3 | Memorial Stadium (1-0) | 18-23 | Won 2 |
| » Starters: Dick Tidrow vs Dave McNally | Fifth | 3 out |
| Future Indian Julian Tavarez is born in Santiago, D.R. |
| Thursday, May 24 |
| Future Indian Bartolo Colon is born in Altamira, D.R. |
| Friday, May 25 |
| » Defeated White Sox (24-14), 8-3 | Comiskey Park I (1-0) | 19-23 | Won 3 |
| » Starters: Dick Bosman vs Rich Gossage | Fifth | 3 out |
| Saturday, May 26 |
| » Major-league debuts: Bill Sharp (White Sox) |
| Monday, May 28 |
| » Lost to White Sox (25-14), 4-0 | Comiskey Park I (1-1) | 19-24 | |
| » Starters: Dick Tidrow vs Wilbur Wood | Sixth | 5 out |
| » Lost to White Sox (26-14), 6-3 | Comiskey Park I (1-2) | 19-25 | Lost 2 |
| » Starters: Gaylord Perry vs Stan Bahnsen | Sixth | 5 out |
| Tuesday, May 29 |
| » Defeated Rangers (13-28), 9-7 | Arlington Stadium (1-0) | 20-25 | |
| » Starters: Dick Bosman vs Lloyd Allen | Fifth | 4½ out |
| Wednesday, May 30 |
| » Lost to Rangers (14-28), 3-2 | Arlington Stadium (1-1) | 20-26 | |
| » Starters: Gaylord Perry vs Pete Broberg | Fifth | 5½ out |
| Thursday, May 31 |
| » Lost to Rangers (15-28), 9-5 | Arlington Stadium (1-2) | 20-27 | Lost 2 |
| » Starters: Brent Strom vs Sonny Siebert | Fifth | 5½ out |
| Friday, June 1 |
| » Lost to Royals (28-23), 5-4 | Royals Stadium (0-1) | 20-28 | Lost 3 |
| » Starters: Dick Tidrow vs Dick Drago | Sixth | 6½ out |
| Saturday, June 2 |
| » Lost to Royals (29-23), 5-1 | Royals Stadium (0-2) | 20-29 | Lost 4 |
| » Starters: Milt Wilcox vs Paul Splittorff | Sixth | 6½ out |
| Sunday, June 3 |
| » Lost to Royals (30-23), 5-4 | Royals Stadium (0-3) | 20-30 | Lost 5 |
| » Starters: Gaylord Perry vs Steve Busby | Sixth | 7½ out |
| Wednesday, June 6 |
| » Lost to Twins (27-21), 7-3 | Cleveland Stadium (9-13) | 20-31 | Lost 6 |
| » Starters: Jim Kaat vs Dick Tidrow | Sixth | 8½ out |
| » Lost to Twins (28-21), 13-9 | Cleveland Stadium (9-14) | 20-32 | Lost 7 |
| » Starters: Joe Decker vs Ray Lamb | Sixth | 8½ out |
| Friday, June 8 |
| » Lost to White Sox (29-20), 5-2 | Cleveland Stadium (9-15) | 20-33 | Lost 8 |
| » Starters: Wilbur Wood vs Milt Wilcox | Sixth | 9 out |
| Saturday, June 9 |
| » Lost to White Sox (30-20), 6-3 | Cleveland Stadium (9-16) | 20-34 | Lost 9 |
| » Starters: Eddie Fisher vs Gaylord Perry | Sixth | 9½ out |
| Sunday, June 10 |
| » Lost to White Sox (31-20), 5-3 | Cleveland Stadium (9-17) | 20-35 | Lost 10 |
| » Starters: Steve Stone vs Dick Tidrow | Sixth | 9 out |
| » Defeated White Sox (31-21), 6-5 | Cleveland Stadium (10-17) | 21-35 | |
| » Starters: Eddie Fisher vs Dick Bosman | Sixth | 9 out |
| Tuesday, June 12 |
| » Defeated Rangers (18-35), 5-4 | Cleveland Stadium (11-17) | 22-35 | Won 2 |
| » Starters: Jim Merritt vs Milt Wilcox | Sixth | 8½ out |
| Wednesday, June 13 |
| » Lost to Rangers (19-35), 4-2 | Cleveland Stadium (11-18) | 22-36 | |
| » Starters: Pete Broberg vs Gaylord Perry | Fifth | 9 out |
| Friday, June 15 |
| » Lost to Royals (33-30), 7-2 | Cleveland Stadium (11-19) | 22-37 | Lost 2 |
| » Starters: Paul Splittorff vs Dick Tidrow | Sixth | 9½ out |
| Saturday, June 16 |
| » Lost to Royals (34-30), 5-2 | Cleveland Stadium (11-20) | 22-38 | Lost 3 |
| » Starters: Steve Busby vs Dick Bosman | Sixth | 10½ out |
| Sunday, June 17 |
| » Lost to Royals (35-30), 6-3 | Cleveland Stadium (11-21) | 22-39 | Lost 4 |
| » Starters: Dick Drago vs Gaylord Perry | Sixth | 12 out |
| » Lost to Royals (36-30), 6-2 | Cleveland Stadium (11-22) | 22-40 | Lost 5 |
| » Starters: Ken Wright vs Mike Kekich | Sixth | 12 out |
| Monday, June 18 |
| » Lost to Tigers (32-29), 5-1 | Cleveland Stadium (11-23) | 22-41 | Lost 6 |
| » Starters: Jim Perry vs Brent Strom | Sixth | 13 out |
| Tuesday, June 19 |
| » Defeated Tigers (32-30), 8-7 | Cleveland Stadium (12-23) | 23-41 | |
| » Starters: Woodie Fryman vs Dick Tidrow | Sixth | 11½ out |
| Wednesday, June 20 |
| » Defeated Tigers (32-31), 7-6 | Cleveland Stadium (13-23) | 24-41 | Won 2 |
| » Starters: Joe Coleman vs Dick Bosman | Sixth | 11 out |
| Thursday, June 21 |
| » Defeated Brewers (34-31), 9-1 | County Stadium (2-1) | 25-41 | Won 3 |
| » Starters: Gaylord Perry vs Jerry Bell | Sixth | 11 out |
| Friday, June 22 |
| » Lost to Brewers (35-31), 8-2 | County Stadium (2-2) | 25-42 | |
| » Starters: Mike Kekich vs Jim Colborn | Sixth | 12 out |
| Saturday, June 23 |
| » Lost to Brewers (36-31), 12-3 | County Stadium (2-3) | 25-43 | Lost 2 |
| » Starters: Dick Tidrow vs Jim Slaton | Sixth | 13 out |
| Sunday, June 24 |
| » Lost to Brewers (37-31), 8-3 | County Stadium (2-4) | 25-44 | Lost 3 |
| » Starters: Dick Bosman vs Bill Parsons | Sixth | 14½ out |
| Monday, June 25 |
| » Defeated Yankees (40-31), 4-2 | Cleveland Stadium (14-23) | 26-44 | |
| » Starters: Mel Stottlemyre vs Gaylord Perry | Sixth | 13½ out |
| Tuesday, June 26 |
| » Lost to Yankees (41-31), 10-2 | Cleveland Stadium (14-24) | 26-45 | |
| » Starters: Pat Dobson vs Brent Strom | Sixth | 14½ out |
| Wednesday, June 27 |
| » Major-league debuts: David Clyde (Rangers) |
| Thursday, June 28 |
| » Defeated Red Sox (34-35), 4-2 | Fenway Park (2-3) | 27-45 | |
| » Starters: Dick Tidrow vs Ray Culp | Sixth | 13½ out |
| » Lost to Red Sox (35-35), 16-7 | Fenway Park (2-4) | 27-46 | |
| » Starters: Dick Bosman vs Marty Pattin | Sixth | 13½ out |
| Friday, June 29 |
| » Lost to Yankees (42-33), 7-2 | Yankee Stadium (1-3) | 27-47 | Lost 2 |
| » Starters: Gaylord Perry vs Doc Medich | Sixth | 14½ out |
| Future Indian Jason Rakers is born in Pittsburgh, PA. |
| Saturday, June 30 |
| » Lost to Yankees (43-33), 7-3 | Yankee Stadium (1-4) | 27-48 | Lost 3 |
| » Starters: Brent Strom vs Mel Stottlemyre | Sixth | 15½ out |
| Sunday, July 1 |
| » Lost to Yankees (44-33), 5-2 | Yankee Stadium (1-5) | 27-49 | Lost 4 |
| » Starters: Tom Hilgendorf vs Pat Dobson | Sixth | 17½ out |
| » Lost to Yankees (45-33), 11-3 | Yankee Stadium (1-6) | 27-50 | Lost 5 |
| » Starters: Tom Timmermann vs Dave Pagan | Sixth | 17½ out |
| » Major-league debuts: Dave Pagan (Yankees) |
| Monday, July 2 |
| » Lost to Tigers (40-38), 4-3 | Cleveland Stadium (14-25) | 27-51 | Lost 6 |
| » Starters: Woodie Fryman vs Dick Tidrow | Sixth | 17½ out |
| Tuesday, July 3 |
| » Lost to Tigers (41-38), 5-4 | Cleveland Stadium (14-26) | 27-52 | Lost 7 |
| » Starters: Jim Perry vs Gaylord Perry | Sixth | 18½ out |
| » Major-league debuts: Alan Ashby (Indians) |
| Wednesday, July 4 |
| » Defeated Tigers (41-39), 5-2 | Tiger Stadium (2-2) | 28-52 | |
| » Starters: Milt Wilcox vs Mike Strahler | Sixth | 17 out |
| Thursday, July 5 |
| » Lost to Tigers (42-39), 7-5 | Tiger Stadium (2-3) | 28-53 | |
| » Starters: Brent Strom vs Mickey Lolich | Sixth | 17 out |
| Friday, July 6 |
| » Defeated Angels (41-38), 8-7 | Cleveland Stadium (15-26) | 29-53 | |
| » Starters: Clyde Wright vs Dick Tidrow | Sixth | 17 out |
| Saturday, July 7 |
| » Lost to Angels (42-38), 3-1 | Cleveland Stadium (15-27) | 29-54 | |
| » Starters: Nolan Ryan vs Gaylord Perry | Sixth | 16½ out |
| Sunday, July 8 |
| » Lost to Angels (43-38), 10-4 | Cleveland Stadium (15-28) | 29-55 | Lost 2 |
| » Starters: Bill Singer vs Milt Wilcox | Sixth | 18 out |
| » Lost to Angels (44-38), 5-3 | Cleveland Stadium (15-29) | 29-56 | Lost 3 |
| » Starters: Dick Lange vs Dick Bosman | Sixth | 18 out |
| Tuesday, July 10 |
| » Defeated Athletics (48-39), 7-5 | Cleveland Stadium (16-29) | 30-56 | |
| » Starters: Blue Moon Odom vs Dick Tidrow | Sixth | 16½ out |
| Wednesday, July 11 |
| » Lost to Athletics (49-39), 9-3 | Cleveland Stadium (16-30) | 30-57 | |
| » Starters: Catfish Hunter vs Gaylord Perry | Sixth | 17½ out |
| Thursday, July 12 |
| » Lost to Twins (45-40), 8-4 | Metropolitan Stadium (1-1) | 30-58 | Lost 2 |
| » Starters: Milt Wilcox vs Dick Woodson | Sixth | 18 out |
| » Defeated Twins (45-41), 7-4 | Metropolitan Stadium (2-1) | 31-58 | |
| » Starters: Brent Strom vs Eddie Bane | Sixth | 18 out |
| Friday, July 13 |
| » Defeated Twins (45-42), 11-2 | Metropolitan Stadium (3-1) | 32-58 | Won 2 |
| » Starters: Dick Bosman vs Joe Decker | Sixth | 18 out |
| Saturday, July 14 |
| » Defeated Twins (45-43), 3-0 | Metropolitan Stadium (4-1) | 33-58 | Won 3 |
| » Starters: Dick Tidrow vs Jim Kaat | Sixth | 17 out |
| » Major-league debuts: Bill Campbell (Twins) |
| Sunday, July 15 |
| » Lost to Twins (46-43), 7-6 | Metropolitan Stadium (4-2) | 33-59 | |
| » Starters: Gaylord Perry vs Bert Blyleven | Sixth | 18 out |
| Monday, July 16 |
| » Defeated Angels (46-44), 9-8 | Anaheim Stadium (3-1) | 34-59 | |
| » Starters: Milt Wilcox vs Bill Singer | Sixth | 17½ out |
| Tuesday, July 17 |
| » Lost to Angels (47-44), 3-1 | Anaheim Stadium (3-2) | 34-60 | |
| » Starters: Dick Bosman vs Clyde Wright | Sixth | 19 out |
| Wednesday, July 18 |
| » Defeated Angels (47-45), 10-8 | Anaheim Stadium (4-2) | 35-60 | |
| » Starters: Dick Tidrow vs Rudy May | Sixth | 18 out |
| Friday, July 20 |
| » Lost to Athletics (54-42), 6-5 | Oakland-Alameda County Stadium (1-3) | 35-61 | |
| » Starters: Gaylord Perry vs Catfish Hunter | Sixth | 19½ out |
| Saturday, July 21 |
| » Lost to Athletics (55-42), 5-2 | Oakland-Alameda County Stadium (1-4) | 35-62 | Lost 2 |
| » Starters: Milt Wilcox vs Vida Blue | Sixth | 20 out |
| Sunday, July 22 |
| » Lost to Athletics (56-42), 5-2 | Oakland-Alameda County Stadium (1-5) | 35-63 | Lost 3 |
| » Starters: Dick Bosman vs Ken Holtzman | Sixth | 20½ out |
| Thursday, July 26 |
| » Lost to Orioles (52-41), 8-4 | Memorial Stadium (1-1) | 35-64 | Lost 4 |
| » Starters: Gaylord Perry vs Dave McNally | Sixth | 21 out |
| » Defeated Orioles (52-42), 6-4 | Memorial Stadium (2-1) | 36-64 | |
| » Starters: Dick Tidrow vs Mike Cuellar | Sixth | 21 out |
| Friday, July 27 |
| » Lost to Orioles (53-42), 9-0 | Memorial Stadium (2-2) | 36-65 | |
| » Starters: Dick Bosman vs Jim Palmer | Sixth | 22½ out |
| » Lost to Orioles (54-42), 5-2 | Memorial Stadium (2-3) | 36-66 | Lost 2 |
| » Starters: Brent Strom vs Jesse Jefferson | Sixth | 22½ out |
| Future Indian Enrique Wilson is born in Santo Domingo, D.R. |
| Saturday, July 28 |
| » Lost to Red Sox (53-46), 7-4 | Cleveland Stadium (16-31) | 36-67 | Lost 3 |
| » Starters: John Curtis vs Mike Kekich | Sixth | 22½ out |
| Sunday, July 29 |
| » Defeated Red Sox (53-47), 8-2 | Cleveland Stadium (17-31) | 37-67 | |
| » Starters: Marty Pattin vs Gaylord Perry | Fifth | 20½ out |
| » Defeated Red Sox (53-48), 6-2 | Cleveland Stadium (18-31) | 38-67 | Won 2 |
| » Starters: Ray Culp vs Tom Timmermann | Fifth | 20½ out |
| Tuesday, July 31 |
| » Lost to Orioles (55-45), 5-1 | Cleveland Stadium (18-32) | 38-68 | |
| » Starters: Jim Palmer vs Dick Tidrow | Sixth | 21 out |
| Wednesday, August 1 |
| » Lost to Orioles (56-45), 4-2 | Cleveland Stadium (18-33) | 38-69 | Lost 2 |
| » Starters: Mike Cuellar vs Dick Bosman | Sixth | 21 out |
| Thursday, August 2 |
| » Defeated Orioles (56-46), 6-0 | Cleveland Stadium (19-33) | 39-69 | |
| » Starters: Don Hood vs Gaylord Perry | Sixth | 20 out |
| Friday, August 3 |
| » Defeated Brewers (51-55), 9-4 | Cleveland Stadium (20-33) | 40-69 | Won 2 |
| » Starters: Bill Parsons vs Tom Timmermann | Sixth | 19½ out |
| Saturday, August 4 |
| » Lost to Brewers (52-55), 9-4 | Cleveland Stadium (20-34) | 40-70 | |
| » Starters: Jim Colborn vs Dick Tidrow | Sixth | 20½ out |
| Future Indian Bobby Howry is born in Phoenix, AZ. |
| Sunday, August 5 |
| » Defeated Brewers (52-56), 6-5 | Cleveland Stadium (21-34) | 41-70 | |
| » Starters: Jim Slaton vs Dick Bosman | Sixth | 19 out |
| » Defeated Brewers (52-57), 4-1 | Cleveland Stadium (22-34) | 42-70 | Won 2 |
| » Starters: Skip Lockwood vs Brent Strom | Sixth | 19 out |
| Monday, August 6 |
| » Defeated White Sox (55-57), 7-3 | Comiskey Park I (2-2) | 43-70 | Won 3 |
| » Starters: Gaylord Perry vs Steve Stone | Sixth | 18½ out |
| Tuesday, August 7 |
| » Lost to White Sox (56-57), 6-5 | Comiskey Park I (2-3) | 43-71 | |
| » Starters: Tom Timmermann vs Wilbur Wood | Sixth | 19 out |
| Future Indian Danny Graves is born in Saigon, South Vietnam. |
| Wednesday, August 8 |
| » Defeated White Sox (56-58), 13-1 | Comiskey Park I (3-3) | 44-71 | |
| » Starters: Dick Tidrow vs Stan Bahnsen | Sixth | 19 out |
| Friday, August 10 |
| » Defeated Rangers (42-71), 8-1 | Arlington Stadium (2-2) | 45-71 | Won 2 |
| » Starters: Gaylord Perry vs David Clyde | Sixth | 18½ out |
| Saturday, August 11 |
| » Defeated Rangers (42-72), 5-2 | Arlington Stadium (3-2) | 46-71 | Won 3 |
| » Starters: Tom Timmermann vs Jim Bibby | Sixth | 18½ out |
| Sunday, August 12 |
| » Defeated Rangers (42-73), 7-6 | Arlington Stadium (4-2) | 47-71 | Won 4 |
| » Starters: Dick Tidrow vs Jackie Brown | Sixth | 18½ out |
| Tuesday, August 14 |
| » Lost to Royals (69-51), 8-5 | Royals Stadium (0-4) | 47-72 | |
| » Starters: Gaylord Perry vs Steve Busby | Sixth | 19 out |
| Wednesday, August 15 |
| » Lost to Royals (70-51), 5-1 | Royals Stadium (0-5) | 47-73 | Lost 2 |
| » Starters: Tom Timmermann vs Al Fitzmorris | Sixth | 19½ out |
| Thursday, August 16 |
| » Defeated Royals (70-52), 10-4 | Royals Stadium (1-5) | 48-73 | |
| » Starters: Dick Tidrow vs Paul Splittorff | Sixth | 19 out |
| Future Indian Damian Jackson is born in Los Angeles, CA. |
| Friday, August 17 |
| » Lost to Twins (59-60), 14-2 | Cleveland Stadium (22-35) | 48-74 | |
| » Starters: Bert Blyleven vs Dick Bosman | Sixth | 20 out |
| Saturday, August 18 |
| » Defeated Twins (59-61), 5-0 | Cleveland Stadium (23-35) | 49-74 | |
| » Starters: Dick Woodson vs Gaylord Perry | Sixth | 20 out |
| Sunday, August 19 |
| » Defeated Twins (59-62), 5-3 | Cleveland Stadium (24-35) | 50-74 | Won 2 |
| » Starters: Dave Goltz vs Tom Timmermann | Sixth | 19½ out |
| » Defeated Twins (59-63), 4-3 | Cleveland Stadium (25-35) | 51-74 | Won 3 |
| » Starters: Joe Decker vs Jerry Johnson | Sixth | 19½ out |
| Tuesday, August 21 |
| » Lost to White Sox (59-66), 4-0 | Cleveland Stadium (25-36) | 51-75 | |
| » Starters: Stan Bahnsen vs Dick Tidrow | Sixth | 21 out |
| Wednesday, August 22 |
| » Defeated White Sox (59-67), 1-0 | Cleveland Stadium (26-36) | 52-75 | |
| » Starters: Terry Forster vs Gaylord Perry | Sixth | 21 out |
| Friday, August 24 |
| » Defeated Rangers (43-82), 11-5 | Cleveland Stadium (27-36) | 53-75 | Won 2 |
| » Starters: Don Durham vs Tom Timmermann | Sixth | 21 out |
| Saturday, August 25 |
| » Defeated Rangers (43-83), 6-5 | Cleveland Stadium (28-36) | 54-75 | Won 3 |
| » Starters: Jim Bibby vs Dick Tidrow | Sixth | 21 out |
| Sunday, August 26 |
| » Lost to Rangers (44-83), 9-0 | Cleveland Stadium (28-37) | 54-76 | |
| » Starters: Jim Merritt vs Gaylord Perry | Sixth | 22½ out |
| » Lost to Rangers (45-83), 5-3 | Cleveland Stadium (28-38) | 54-77 | Lost 2 |
| » Starters: Mike Paul vs Milt Wilcox | Sixth | 22½ out |
| Tuesday, August 28 |
| » Defeated Royals (73-59), 4-3 | Cleveland Stadium (29-38) | 55-77 | |
| » Starters: Dick Drago vs Tom Timmermann | Sixth | 22 out |
| Wednesday, August 29 |
| » Lost to Royals (74-59), 3-2 | Cleveland Stadium (29-39) | 55-78 | |
| » Starters: Steve Busby vs Dick Tidrow | Sixth | 23 out |
| Thursday, August 30 |
| » Defeated Tigers (71-63), 3-0 | Tiger Stadium (3-3) | 56-78 | |
| » Starters: Gaylord Perry vs Joe Coleman | Sixth | 22½ out |
| Friday, August 31 |
| » Defeated Tigers (71-64), 6-3 | Tiger Stadium (4-3) | 57-78 | Won 2 |
| » Starters: Mike Kekich vs Mickey Lolich | Sixth | 21½ out |
| Saturday, September 1 |
| » Defeated Tigers (71-65), 5-4 | Tiger Stadium (5-3) | 58-78 | Won 3 |
| » Starters: Tom Timmermann vs Woodie Fryman | Sixth | 21½ out |
| Sunday, September 2 |
| » Lost to Tigers (72-65), 2-1 | Tiger Stadium (5-4) | 58-79 | |
| » Starters: Dick Tidrow vs Jim Perry | Sixth | 22½ out |
| Monday, September 3 |
| » Lost to Brewers (67-69), 13-5 | County Stadium (2-5) | 58-80 | Lost 2 |
| » Starters: Gaylord Perry vs Jim Slaton | Sixth | 22½ out |
| » Defeated Brewers (67-70), 10-5 | County Stadium (3-5) | 59-80 | |
| » Starters: Milt Wilcox vs Bill Parsons | Sixth | 22½ out |
| Tuesday, September 4 |
| » Defeated Brewers (67-71), 5-4 | County Stadium (4-5) | 60-80 | Won 2 |
| » Starters: Mike Kekich vs Bill Champion | Sixth | 21½ out |
| » Major-league debuts: Wilbur Howard (Brewers) |
| Wednesday, September 5 |
| » Lost to Tigers (74-66), 7-3 | Cleveland Stadium (29-40) | 60-81 | |
| » Starters: Lerrin LaGrow vs Tom Timmermann | Sixth | 21½ out |
| Thursday, September 6 |
| » Defeated Tigers (74-67), 10-4 | Cleveland Stadium (30-40) | 61-81 | |
| » Starters: Woodie Fryman vs Dick Tidrow | Sixth | 21 out |
| Friday, September 7 |
| » Lost to Orioles (80-57), 7-3 | Cleveland Stadium (30-41) | 61-82 | |
| » Starters: Dave McNally vs Gaylord Perry | Sixth | 22 out |
| Saturday, September 8 |
| » Lost to Orioles (81-57), 6-1 | Cleveland Stadium (30-42) | 61-83 | Lost 2 |
| » Starters: Jim Palmer vs Milt Wilcox | Sixth | 23 out |
| Sunday, September 9 |
| » Defeated Orioles (81-58), 6-4 | Cleveland Stadium (31-42) | 62-83 | |
| » Starters: Doyle Alexander vs Brent Strom | Sixth | 23 out |
| » Lost to Orioles (82-58), 13-4 | Cleveland Stadium (31-43) | 62-84 | |
| » Starters: Mike Cuellar vs Tom Timmermann | Sixth | 23 out |
| » Major-league debuts: Doug DeCinces (Orioles) |
| Monday, September 10 |
| » Defeated Yankees (72-72), 3-2 | Yankee Stadium (2-6) | 63-84 | |
| » Starters: Dick Tidrow vs Fritz Peterson | Sixth | 22 out |
| Tuesday, September 11 |
| » Defeated Yankees (72-73), 7-3 | Yankee Stadium (3-6) | 64-84 | Won 2 |
| » Starters: Gaylord Perry vs Pat Dobson | Sixth | 22 out |
| Friday, September 14 |
| » Lost to Red Sox (81-67), 6-4 | Fenway Park (2-5) | 64-85 | |
| » Starters: Tom Timmermann vs Luis Tiant | Sixth | 24 out |
| Saturday, September 15 |
| » Defeated Red Sox (81-68), 9-8 | Fenway Park (3-5) | 65-85 | |
| » Starters: Dick Tidrow vs Marty Pattin | Sixth | 23 out |
| Sunday, September 16 |
| » Defeated Red Sox (81-69), 5-1 | Fenway Park (4-5) | 66-85 | Won 2 |
| » Starters: Gaylord Perry vs Roger Moret | Sixth | 22½ out |
| Tuesday, September 18 |
| » Defeated Brewers (71-80), 6-5 | Cleveland Stadium (32-43) | 67-85 | Won 3 |
| » Starters: Jim Colborn vs Milt Wilcox | Sixth | 23 out |
| Wednesday, September 19 |
| » Lost to Brewers (72-80), 7-4 | Cleveland Stadium (32-44) | 67-86 | |
| » Starters: Jim Slaton vs Dick Tidrow | Sixth | 23 out |
| Saturday, September 22 |
| » Defeated Yankees (75-79), 5-1 | Cleveland Stadium (33-44) | 68-86 | |
| » Starters: Pat Dobson vs Gaylord Perry | Sixth | 24 out |
