| Tuesday, January 25 |
| Future White Sox Bryan Ward is born in Bristol, PA. |
| Friday, February 11 |
| Future White Sox Brian Daubach is born in Belleville, IL. |
| Thursday, March 30 |
| Former White Sox Davy Jones dies in Mankato, MN at the age of 92. |
| Saturday, April 15 |
| » Lost to Royals (1-0), 2-1 | Municipal Stadium (0-1) | 0-1 | |
| » Starters: Wilbur Wood vs Dick Drago | Second | 1 out |
| » Major-league debuts: Jorge Orta (White Sox) |
| Sunday, April 16 |
| » Lost to Royals (2-0), 2-1 | Municipal Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Stan Bahnsen vs Paul Splittorff | Third | 3 out |
| » Lost to Royals (3-0), 4-3 | Municipal Stadium (0-3) | 0-3 | Lost 3 |
| » Starters: Tom Bradley vs Monty Montgomery | Third | 3 out |
| » Major-league debuts: Goose Gossage (White Sox) |
| Tuesday, April 18 |
| » Defeated Rangers (1-2), 14-0 | Comiskey Park I (1-0) | 1-3 | |
| » Starters: Bill Gogolewski vs Wilbur Wood | Fourth | 2 out |
| Wednesday, April 19 |
| » Defeated Rangers (1-3), 2-1 | Comiskey Park I (2-0) | 2-3 | Won 2 |
| » Starters: Don Stanhouse vs Stan Bahnsen | Fourth | 2 out |
| » Major-league debuts: Don Stanhouse (Rangers) |
| Saturday, April 22 |
| » Defeated Royals (3-4), 1-0 | Comiskey Park I (3-0) | 3-3 | Won 3 |
| » Starters: Paul Splittorff vs Wilbur Wood | Second | 1 out |
| » Defeated Royals (3-5), 3-2 | Comiskey Park I (4-0) | 4-3 | Won 4 |
| » Starters: Monty Montgomery vs Tom Bradley | Second | 1 out |
| Sunday, April 23 |
| » Defeated Royals (3-6), 3-2 | Comiskey Park I (5-0) | 5-3 | Won 5 |
| » Starters: Mike Hedlund vs Stan Bahnsen | Second | 1 out |
| Tuesday, April 25 |
| » Defeated Indians (4-4), 6-0 | Comiskey Park I (6-0) | 6-3 | Won 6 |
| » Starters: Milt Wilcox vs Wilbur Wood | Second | 1 out |
| Wednesday, April 26 |
| » Defeated Indians (4-5), 7-5 | Comiskey Park I (7-0) | 7-3 | Won 7 |
| » Starters: Dick Tidrow vs Tom Bradley | Second | 1½ out |
| Friday, April 28 |
| » Lost to Tigers (6-3), 12-0 | Tiger Stadium (0-1) | 7-4 | |
| » Starters: Stan Bahnsen vs Tom Timmermann | Third | 1½ out |
| Saturday, April 29 |
| » Lost to Tigers (7-3), 6-1 | Tiger Stadium (0-2) | 7-5 | Lost 2 |
| » Starters: Wilbur Wood vs Mickey Lolich | Third | 1½ out |
| Sunday, April 30 |
| » Defeated Tigers (7-4), 6-3 | Tiger Stadium (1-2) | 8-5 | |
| » Starters: Tom Bradley vs Joe Coleman | Third | 1 out |
| Tuesday, May 2 |
| » Lost to Orioles (8-6), 3-0 | Memorial Stadium (0-1) | 8-6 | |
| » Starters: Stan Bahnsen vs Dave McNally | Third | 1½ out |
| Friday, May 5 |
| » Defeated Indians (8-7), 2-1 | Cleveland Stadium (1-0) | 9-6 | |
| » Starters: Wilbur Wood vs Dick Tidrow | Third | 2 out |
| Saturday, May 6 |
| » Lost to Indians (9-7), 12-0 | Cleveland Stadium (1-1) | 9-7 | |
| » Starters: Tom Bradley vs Gaylord Perry | Third | 3 out |
| Sunday, May 7 |
| » Lost to Indians (10-7), 3-0 | Cleveland Stadium (1-2) | 9-8 | Lost 2 |
| » Starters: Stan Bahnsen vs Milt Wilcox | Third | 4 out |
| Tuesday, May 9 |
| » Lost to Tigers (11-6), 5-2 | Comiskey Park I (7-1) | 9-9 | Lost 3 |
| » Starters: Joe Coleman vs Wilbur Wood | Third | 4½ out |
| Wednesday, May 10 |
| » Defeated Tigers (11-7), 7-0 | Comiskey Park I (8-1) | 10-9 | |
| » Starters: Tom Timmermann vs Tom Bradley | Third | 4½ out |
| » Major-league debuts: Phil Meeler and Bob Strampe (Tigers) |
| Friday, May 12 |
| » Defeated Orioles (11-9), 4-3 | Comiskey Park I (9-1) | 11-9 | Won 2 |
| » Starters: Mike Cuellar vs Wilbur Wood | Third | 3½ out |
| Saturday, May 13 |
| » Defeated Orioles (11-10), 9-3 | Comiskey Park I (10-1) | 12-9 | Won 3 |
| » Starters: Pat Dobson vs Stan Bahnsen | Third | 3½ out |
| Sunday, May 14 |
| » Defeated Orioles (11-11), 4-1 | Comiskey Park I (11-1) | 13-9 | Won 4 |
| » Starters: Dave McNally vs Tom Bradley | Third | 3½ out |
| Monday, May 15 |
| » Defeated Twins (16-6), 4-3 | Comiskey Park I (12-1) | 14-9 | Won 5 |
| » Starters: Jim Perry vs Wilbur Wood | Third | 2½ out |
| Tuesday, May 16 |
| » Defeated Twins (16-7), 2-1 | Comiskey Park I (13-1) | 15-9 | Won 6 |
| » Starters: Dick Woodson vs Stan Bahnsen | Third | 1½ out |
| Wednesday, May 17 |
| » Lost to Twins (17-7), 8-1 | Comiskey Park I (13-2) | 15-10 | |
| » Starters: Bert Blyleven vs Tom Bradley | Third | 2½ out |
| Friday, May 19 |
| » Defeated Angels (11-17), 3-1 | Comiskey Park I (14-2) | 16-10 | |
| » Starters: Eddie Fisher vs Wilbur Wood | Second | 1½ out |
| Saturday, May 20 |
| » Defeated Angels (11-18), 8-0 | Comiskey Park I (15-2) | 17-10 | Won 2 |
| » Starters: Rickey Clark vs Stan Bahnsen | Second | ½ out |
| Sunday, May 21 |
| » Defeated Angels (11-19), 9-8 | Comiskey Park I (16-2) | 18-10 | Won 3 |
| » Starters: Rudy May vs Tom Bradley | First | -- |
| Monday, May 22 |
| » Defeated Rangers (15-16), 7-6 | Arlington Stadium (1-0) | 19-10 | Won 4 |
| » Starters: Wilbur Wood vs Dick Bosman | First | -- |
| Tuesday, May 23 |
| » Defeated Rangers (15-17), 2-1 | Arlington Stadium (2-0) | 20-10 | Won 5 |
| » Starters: Stan Bahnsen vs Jerry Janeski | First | -- |
| Wednesday, May 24 |
| » Defeated Rangers (15-18), 5-1 | Arlington Stadium (3-0) | 21-10 | Won 6 |
| » Starters: Tom Bradley vs Bill Gogolewski | First | -- |
| Friday, May 26 |
| » Lost to Athletics (20-11), 4-2 | Oakland-Alameda County Stadium (0-1) | 21-11 | |
| » Starters: Wilbur Wood vs Ken Holtzman | First | -- |
| Saturday, May 27 |
| » Lost to Athletics (21-11), 6-3 | Oakland-Alameda County Stadium (0-2) | 21-12 | Lost 2 |
| » Starters: Stan Bahnsen vs Catfish Hunter | Second | ½ out |
| Sunday, May 28 |
| » Lost to Athletics (22-11), 5-4 | Oakland-Alameda County Stadium (0-3) | 21-13 | Lost 3 |
| » Starters: Tom Bradley vs Vida Blue | Third | 1½ out |
| Monday, May 29 |
| » Defeated Angels (15-23), 5-4 | Anaheim Stadium (1-0) | 22-13 | |
| » Starters: Wilbur Wood vs Don Rose | Third | 2½ out |
| » Lost to Angels (16-23), 3-2 | Anaheim Stadium (1-1) | 22-14 | |
| » Starters: Dave Lemonds vs Rudy May | Third | 2½ out |
| Former White Sox Moe Berg dies in Belleville, NJ at the age of 71. |
| Tuesday, May 30 |
| » Lost to Angels (17-23), 6-0 | Anaheim Stadium (1-2) | 22-15 | Lost 2 |
| » Starters: Stan Bahnsen vs Nolan Ryan | Third | 2½ out |
| Future White Sox Scott Eyre is born in Inglewood, CA. |
| Wednesday, May 31 |
| » Lost to Angels (18-23), 4-3 | Anaheim Stadium (1-3) | 22-16 | Lost 3 |
| » Starters: Tom Bradley vs Rickey Clark | Third | 3½ out |
| Friday, June 2 |
| » Defeated Yankees (17-22), 6-1 | Comiskey Park I (17-2) | 23-16 | |
| » Starters: Fritz Peterson vs Wilbur Wood | Third | 2½ out |
| Saturday, June 3 |
| » Lost to Yankees (18-22), 18-10 | Comiskey Park I (17-3) | 23-17 | |
| » Starters: Fred Beene vs Stan Bahnsen | Third | 3½ out |
| Sunday, June 4 |
| » Defeated Yankees (18-23), 6-1 | Comiskey Park I (18-3) | 24-17 | |
| » Starters: Mel Stottlemyre vs Tom Bradley | Second | 3½ out |
| » Defeated Yankees (18-24), 5-4 | Comiskey Park I (19-3) | 25-17 | Won 2 |
| » Starters: Mike Kekich vs Dave Lemonds | Second | 3½ out |
| » Major-league debuts: Cy Acosta (White Sox) |
| Tuesday, June 6 |
| » Lost to Red Sox (18-22), 2-0 | Comiskey Park I (19-4) | 25-18 | |
| » Starters: Sonny Siebert vs Wilbur Wood | Third | 5 out |
| Future White Sox Tony Graffanino is born in Amityville, NY. |
| Wednesday, June 7 |
| » Defeated Red Sox (18-23), 2-1 | Comiskey Park I (20-4) | 26-18 | |
| » Starters: Luis Tiant vs Stan Bahnsen | Third | 5 out |
| Friday, June 9 |
| » Defeated Brewers (16-26), 3-2 | Comiskey Park I (21-4) | 27-18 | Won 2 |
| » Starters: Skip Lockwood vs Wilbur Wood | Second | 5 out |
| Saturday, June 10 |
| » Defeated Brewers (16-27), 6-1 | Comiskey Park I (22-4) | 28-18 | Won 3 |
| » Starters: Ken Brett vs Tom Bradley | Second | 5 out |
| Sunday, June 11 |
| » Defeated Brewers (16-28), 6-4 | Comiskey Park I (23-4) | 29-18 | Won 4 |
| » Starters: Jim Lonborg vs Stan Bahnsen | Second | 3½ out |
| » Defeated Brewers (16-29), 5-4 | Comiskey Park I (24-4) | 30-18 | Won 5 |
| » Starters: Jim Slaton vs Dave Lemonds | Second | 3½ out |
| Tuesday, June 13 |
| » Defeated Yankees (20-29), 2-0 | Yankee Stadium (1-0) | 31-18 | Won 6 |
| » Starters: Wilbur Wood vs Mel Stottlemyre | Second | 2 out |
| Wednesday, June 14 |
| » Lost to Yankees (21-29), 3-0 | Yankee Stadium (1-1) | 31-19 | |
| » Starters: Tom Bradley vs Mike Kekich | Second | 2 out |
| Thursday, June 15 |
| » Lost to Yankees (22-29), 8-1 | Yankee Stadium (1-2) | 31-20 | Lost 2 |
| » Starters: Stan Bahnsen vs Fritz Peterson | Second | 2½ out |
| Saturday, June 17 |
| » Defeated Red Sox (21-27), 5-4 | Fenway Park (1-0) | 32-20 | |
| » Starters: Wilbur Wood vs Ray Culp | Second | 3½ out |
| » Lost to Red Sox (22-27), 10-8 | Fenway Park (1-1) | 32-21 | |
| » Starters: Tom Bradley vs Marty Pattin | Second | 3½ out |
| Sunday, June 18 |
| » Defeated Red Sox (22-28), 8-4 | Fenway Park (2-1) | 33-21 | |
| » Starters: Stan Bahnsen vs John Curtis | Second | 3½ out |
| Tuesday, June 20 |
| » Lost to Brewers (18-34), 7-1 | County Stadium (0-1) | 33-22 | |
| » Starters: Wilbur Wood vs Jim Lonborg | Second | 5 out |
| Wednesday, June 21 |
| » Defeated Brewers (18-35), 9-3 | County Stadium (1-1) | 34-22 | |
| » Starters: Tom Bradley vs Bill Parsons | Second | 4 out |
| Thursday, June 22 |
| » Defeated Brewers (18-36), 5-2 | County Stadium (2-1) | 35-22 | Won 2 |
| » Starters: Stan Bahnsen vs Skip Lockwood | Second | 3½ out |
| Friday, June 23 |
| » Lost to Rangers (25-34), 4-3 | Arlington Stadium (3-1) | 35-23 | |
| » Starters: Wilbur Wood vs Dick Bosman | Second | 3½ out |
| Saturday, June 24 |
| » Lost to Rangers (26-34), 6-1 | Arlington Stadium (3-2) | 35-24 | Lost 2 |
| » Starters: Dave Lemonds vs Pete Broberg | Second | 3½ out |
| Sunday, June 25 |
| » Defeated Rangers (26-35), 10-5 | Arlington Stadium (4-2) | 36-24 | |
| » Starters: Tom Bradley vs Rich Hand | Second | 4 out |
| Monday, June 26 |
| » Lost to Royals (28-32), 4-1 | Municipal Stadium (0-4) | 36-25 | |
| » Starters: Wilbur Wood vs Bruce DalCanton | Second | 5 out |
| Tuesday, June 27 |
| » Lost to Royals (29-32), 6-4 | Municipal Stadium (0-5) | 36-26 | Lost 2 |
| » Starters: Stan Bahnsen vs Paul Splittorff | Second | 6 out |
| Wednesday, June 28 |
| » Defeated Athletics (42-21), 6-4 | Comiskey Park I (25-4) | 37-26 | |
| » Starters: Vida Blue vs Dave Lemonds | Second | 5 out |
| Thursday, June 29 |
| » Defeated Athletics (42-22), 4-0 | Comiskey Park I (26-4) | 38-26 | Won 2 |
| » Starters: Catfish Hunter vs Wilbur Wood | Second | 5 out |
| » Lost to Athletics (43-22), 3-1 | Comiskey Park I (26-5) | 38-27 | |
| » Starters: Blue Moon Odom vs Tom Bradley | Second | 5 out |
| Friday, June 30 |
| » Defeated Athletics (43-23), 6-5 | Comiskey Park I (27-5) | 39-27 | |
| » Starters: Ken Holtzman vs Stan Bahnsen | Second | 4 out |
| Saturday, July 1 |
| » Defeated Twins (35-30), 5-1 | Comiskey Park I (28-5) | 40-27 | Won 2 |
| » Starters: Jim Perry vs Dave Lemonds | Second | 3 out |
| » Major-league debuts: Glenn Borgmann (Twins) |
| Sunday, July 2 |
| » Lost to Twins (36-30), 6-4 | Comiskey Park I (28-6) | 40-28 | |
| » Starters: Jim Kaat vs Wilbur Wood | Second | 3½ out |
| » Defeated Twins (36-31), 2-1 | Comiskey Park I (29-6) | 41-28 | |
| » Starters: Dick Woodson vs Tom Bradley | Second | 3½ out |
| Tuesday, July 4 |
| » Lost to Orioles (38-30), 2-1 | Comiskey Park I (29-7) | 41-29 | |
| » Starters: Pat Dobson vs Stan Bahnsen | Second | 5 out |
| Wednesday, July 5 |
| » Lost to Orioles (39-30), 1-0 | Comiskey Park I (29-8) | 41-30 | Lost 2 |
| » Starters: Dave McNally vs Wilbur Wood | Second | 5 out |
| » Major-league debuts: Hugh Yancy (White Sox) |
| Thursday, July 6 |
| » Lost to Orioles (40-30), 2-1 | Comiskey Park I (29-9) | 41-31 | Lost 3 |
| » Starters: Mike Cuellar vs Tom Bradley | Second | 5 out |
| Future White Sox Greg Norton is born in San Leandro, CA. |
| Friday, July 7 |
| » Lost to Tigers (39-32), 6-4 | Comiskey Park I (29-10) | 41-32 | Lost 4 |
| » Starters: Tom Timmermann vs Dave Lemonds | Second | 5 out |
| Saturday, July 8 |
| » Defeated Tigers (39-33), 5-2 | Comiskey Park I (30-10) | 42-32 | |
| » Starters: Bill Slayback vs Stan Bahnsen | Second | 5 out |
| Sunday, July 9 |
| » Defeated Tigers (39-34), 5-4 | Comiskey Park I (31-10) | 43-32 | Won 2 |
| » Starters: Fred Scherman vs Wilbur Wood | Second | 5½ out |
| » Lost to Tigers (40-34), 4-2 | Comiskey Park I (31-11) | 43-33 | |
| » Starters: Mickey Lolich vs Tom Bradley | Second | 5½ out |
| Monday, July 10 |
| » Lost to Indians (32-42), 2-1 | Cleveland Stadium (1-3) | 43-34 | Lost 2 |
| » Starters: Dave Lemonds vs Gaylord Perry | Second | 5½ out |
| Tuesday, July 11 |
| » Defeated Indians (32-43), 4-3 | Cleveland Stadium (2-3) | 44-34 | |
| » Starters: Stan Bahnsen vs Dick Tidrow | Second | 4½ out |
| Wednesday, July 12 |
| » Defeated Indians (32-44), 5-4 | Cleveland Stadium (3-3) | 45-34 | Won 2 |
| » Starters: Wilbur Wood vs Mike Kilkenny | Second | 3½ out |
| Future White Sox Kelly Wunsch is born in Houston, TX. |
| Friday, July 14 |
| » Lost to Orioles (42-36), 7-4 | Memorial Stadium (0-2) | 45-35 | |
| » Starters: Tom Bradley vs Dave McNally | Second | 5½ out |
| » Lost to Orioles (43-36), 3-0 | Memorial Stadium (0-3) | 45-36 | Lost 2 |
| » Starters: Dave Lemonds vs Doyle Alexander | Second | 5½ out |
| Saturday, July 15 |
| » Lost to Orioles (44-36), 6-3 | Memorial Stadium (0-4) | 45-37 | Lost 3 |
| » Starters: Stan Bahnsen vs Mike Cuellar | Second | 6½ out |
| Sunday, July 16 |
| » Lost to Orioles (45-36), 6-1 | Memorial Stadium (0-5) | 45-38 | Lost 4 |
| » Starters: Wilbur Wood vs Jim Palmer | Second | 7½ out |
| Monday, July 17 |
| » Lost to Tigers (47-35), 3-1 | Tiger Stadium (1-3) | 45-39 | Lost 5 |
| » Starters: Tom Bradley vs Mickey Lolich | Second | 8 out |
| Tuesday, July 18 |
| » Lost to Tigers (48-35), 4-3 | Tiger Stadium (1-4) | 45-40 | Lost 6 |
| » Starters: Stan Bahnsen vs Joe Coleman | Second | 8½ out |
| Wednesday, July 19 |
| » Defeated Tigers (48-36), 3-2 | Tiger Stadium (2-4) | 46-40 | |
| » Starters: Wilbur Wood vs Tom Timmermann | Second | 8½ out |
| Friday, July 21 |
| » Lost to Indians (36-48), 8-2 | Comiskey Park I (31-12) | 46-41 | |
| » Starters: Dick Tidrow vs Tom Bradley | Second | 7½ out |
| Former White Sox Harry McCurdy dies in Houston, TX at the age of 73. |
| Saturday, July 22 |
| » Defeated Indians (36-49), 5-3 | Comiskey Park I (32-12) | 47-41 | |
| » Starters: Phil Hennigan vs Stan Bahnsen | Second | 7 out |
| Sunday, July 23 |
| » Defeated Indians (36-50), 2-1 | Comiskey Park I (33-12) | 48-41 | Won 2 |
| » Starters: Gaylord Perry vs Wilbur Wood | Second | 6½ out |
| » Defeated Indians (36-51), 4-3 | Comiskey Park I (34-12) | 49-41 | Won 3 |
| » Starters: Steve Dunning vs Dave Lemonds | Second | 6½ out |
| Thursday, July 27 |
| » Defeated Royals (44-46), 7-3 | Comiskey Park I (35-12) | 50-41 | Won 4 |
| » Starters: Paul Splittorff vs Wilbur Wood | Second | 7 out |
| » Lost to Royals (45-46), 3-0 | Comiskey Park I (35-13) | 50-42 | |
| » Starters: Roger Nelson vs Stan Bahnsen | Second | 7 out |
| Friday, July 28 |
| » Defeated Royals (45-47), 5-0 | Comiskey Park I (36-13) | 51-42 | |
| » Starters: Dick Drago vs Tom Bradley | Second | 6 out |
| Saturday, July 29 |
| » Defeated Royals (45-48), 4-3 | Comiskey Park I (37-13) | 52-42 | Won 2 |
| » Starters: Bruce DalCanton vs Dave Lemonds | Second | 6 out |
| Sunday, July 30 |
| » Lost to Twins (47-44), 1-0 | Metropolitan Stadium (0-1) | 52-43 | |
| » Starters: Wilbur Wood vs Jim Perry | Second | 5½ out |
| Monday, July 31 |
| » Defeated Twins (47-45), 8-1 | Metropolitan Stadium (1-1) | 53-43 | |
| » Starters: Stan Bahnsen vs Bert Blyleven | Second | 5½ out |
| Wednesday, August 2 |
| » Defeated Angels (44-54), 10-9 | Comiskey Park I (38-13) | 54-43 | Won 2 |
| » Starters: Clyde Wright vs Tom Bradley | Second | 6 out |
| » Major-league debuts: Dave Sells (Angels) |
| Thursday, August 3 |
| » Defeated Angels (44-55), 4-2 | Comiskey Park I (39-13) | 55-43 | Won 3 |
| » Starters: Andy Messersmith vs Wilbur Wood | Second | 5½ out |
| Friday, August 4 |
| » Defeated Rangers (40-60), 3-2 | Comiskey Park I (40-13) | 56-43 | Won 4 |
| » Starters: Don Stanhouse vs Stan Bahnsen | Second | 4½ out |
| Saturday, August 5 |
| » Lost to Rangers (41-60), 11-5 | Comiskey Park I (40-14) | 56-44 | |
| » Starters: Rich Hand vs Dave Lemonds | Second | 4½ out |
| Sunday, August 6 |
| » Defeated Rangers (41-61), 10-1 | Comiskey Park I (41-14) | 57-44 | |
| » Starters: Pete Broberg vs Wilbur Wood | Second | 3½ out |
| » Defeated Rangers (41-62), 7-1 | Comiskey Park I (42-14) | 58-44 | Won 2 |
| » Starters: Casey Cox vs Tom Bradley | Second | 3½ out |
| Tuesday, August 8 |
| » Defeated Angels (47-57), 4-3 | Anaheim Stadium (2-3) | 59-44 | Won 3 |
| » Starters: Stan Bahnsen vs Andy Messersmith | Second | 2 out |
| Wednesday, August 9 |
| » Defeated Angels (47-58), 1-0 | Anaheim Stadium (3-3) | 60-44 | Won 4 |
| » Starters: Wilbur Wood vs Nolan Ryan | Second | 1 out |
| Thursday, August 10 |
| » Game at Oakland-Alameda County Stadium interrupted in the 18th inning with the score of White Sox 3, Athletics 3. Completed on August 11. |
| Friday, August 11 |
| » Defeated Athletics (62-45), 1-0 | Oakland-Alameda County Stadium (1-3) | 61-44 | Won 5 |
| » Starters: Dave Lemonds vs Catfish Hunter | Second | 1 out |
| » Lost to Athletics (63-45), 5-3 | Oakland-Alameda County Stadium (1-4) | 61-45 | |
| » Starters: Tom Bradley vs Ken Holtzman | Second | 1 out |
| » Major-league debuts: Gonzalo Marquez (Athletics) |
| Future White Sox Andrew Lorraine is born in Los Angeles, CA. |
| Saturday, August 12 |
| » Defeated Athletics (63-46), 3-1 | Oakland-Alameda County Stadium (2-4) | 62-45 | |
| » Starters: Wilbur Wood vs Blue Moon Odom | First | -- |
| Sunday, August 13 |
| » Lost to Athletics (64-46), 3-0 | Oakland-Alameda County Stadium (2-5) | 62-46 | |
| » Starters: Stan Bahnsen vs Vida Blue | Second | 1 out |
| Tuesday, August 15 |
| » Defeated Brewers (43-68), 2-1 | Comiskey Park I (43-14) | 63-46 | |
| » Starters: Bill Parsons vs Tom Bradley | Second | 1 out |
| Future White Sox Chris Singleton is born in Martinez, CA. |
| Wednesday, August 16 |
| » Defeated Brewers (43-69), 8-6 | Comiskey Park I (44-14) | 64-46 | Won 2 |
| » Starters: Gary Ryerson vs Wilbur Wood | Second | 1 out |
| Thursday, August 17 |
| » Defeated Orioles (60-52), 6-1 | Memorial Stadium (1-5) | 65-46 | Won 3 |
| » Starters: Dave Lemonds vs Pat Dobson | Second | ½ out |
| Future White Sox Jeff Abbott is born in Atlanta, GA. |
| Friday, August 18 |
| » Defeated Red Sox (56-55), 8-1 | Comiskey Park I (45-14) | 66-46 | Won 4 |
| » Starters: Sonny Siebert vs Stan Bahnsen | Second | ½ out |
| Saturday, August 19 |
| » Lost to Red Sox (57-55), 3-0 | Comiskey Park I (45-15) | 66-47 | |
| » Starters: Luis Tiant vs Tom Bradley | Second | ½ out |
| Sunday, August 20 |
| » Defeated Red Sox (57-56), 9-7 | Comiskey Park I (46-15) | 67-47 | |
| » Starters: Lynn McGlothen vs Wilbur Wood | First | -- |
| » Lost to Red Sox (58-56), 5-4 | Comiskey Park I (46-16) | 67-48 | |
| » Starters: John Curtis vs Eddie Fisher | First | -- |
| Future White Sox Mike Porzio is born in Waterbury, CT. |
| Tuesday, August 22 |
| » Defeated Yankees (60-55), 5-4 | Comiskey Park I (47-16) | 68-48 | |
| » Starters: Fritz Peterson vs Stan Bahnsen | Second | ½ out |
| Wednesday, August 23 |
| » Defeated Yankees (60-56), 5-2 | Comiskey Park I (48-16) | 69-48 | Won 2 |
| » Starters: Mel Stottlemyre vs Wilbur Wood | First | -- |
| Saturday, August 26 |
| » Defeated Brewers (46-73), 3-1 | County Stadium (3-1) | 70-48 | Won 3 |
| » Starters: Tom Bradley vs Skip Lockwood | First | -- |
| » Lost to Brewers (47-73), 4-0 | County Stadium (3-2) | 70-49 | |
| » Starters: Stan Bahnsen vs Jim Colborn | First | -- |
| Sunday, August 27 |
| » Lost to Brewers (48-73), 4-3 | County Stadium (3-3) | 70-50 | Lost 2 |
| » Starters: Wilbur Wood vs Bill Parsons | First | -- |
| Monday, August 28 |
| » Defeated Red Sox (62-58), 6-4 | Fenway Park (3-1) | 71-50 | |
| » Starters: Dave Lemonds vs Sonny Siebert | First | -- |
| Tuesday, August 29 |
| » Lost to Red Sox (63-58), 3-0 | Fenway Park (3-2) | 71-51 | |
| » Starters: Tom Bradley vs Luis Tiant | Second | ½ out |
| Wednesday, August 30 |
| » Lost to Red Sox (64-58), 4-2 | Fenway Park (3-3) | 71-52 | Lost 2 |
| » Starters: Wilbur Wood vs Lynn McGlothen | Second | 1½ out |
| Friday, September 1 |
| » Lost to Yankees (67-59), 4-0 | Yankee Stadium (1-3) | 71-53 | Lost 3 |
| » Starters: Dave Lemonds vs Mel Stottlemyre | Second | 2½ out |
| » Major-league debuts: Charlie Spikes (Yankees) Ken Frailing (White Sox) |
| Saturday, September 2 |
| » Lost to Yankees (68-59), 2-1 | Yankee Stadium (1-4) | 71-54 | Lost 4 |
| » Starters: Tom Bradley vs Steve Kline | Second | 2½ out |
| Sunday, September 3 |
| » Defeated Yankees (68-60), 5-0 | Yankee Stadium (2-4) | 72-54 | |
| » Starters: Wilbur Wood vs Casey Cox | Second | 2½ out |
| Monday, September 4 |
| » Lost to Twins (63-62), 2-1 | Comiskey Park I (48-17) | 72-55 | |
| » Starters: Bert Blyleven vs Stan Bahnsen | Second | 3½ out |
| » Lost to Twins (64-62), 4-0 | Comiskey Park I (48-18) | 72-56 | Lost 2 |
| » Starters: Ray Corbin vs Dave Lemonds | Second | 3½ out |
| Tuesday, September 5 |
| » Defeated Twins (64-63), 5-2 | Comiskey Park I (49-18) | 73-56 | |
| » Starters: Dave Goltz vs Eddie Fisher | Second | 3 out |
| Wednesday, September 6 |
| » Lost to Athletics (77-53), 9-1 | Comiskey Park I (49-19) | 73-57 | |
| » Starters: Ken Holtzman vs Tom Bradley | Second | 4 out |
| Former White Sox Charlie Berry dies in Evanston, IL at the age of 70. |
| Thursday, September 7 |
| » Defeated Athletics (77-54), 6-0 | Comiskey Park I (50-19) | 74-57 | |
| » Starters: Vida Blue vs Wilbur Wood | Second | 3 out |
| Friday, September 8 |
| » Defeated Angels (61-71), 5-1 | Comiskey Park I (51-19) | 75-57 | Won 2 |
| » Starters: Nolan Ryan vs Stan Bahnsen | Second | 3½ out |
| » Lost to Angels (62-71), 9-4 | Comiskey Park I (51-20) | 75-58 | |
| » Starters: Clyde Wright vs Dave Lemonds | Second | 3½ out |
| » Major-league debuts: Dan Neumeier (White Sox) |
| Saturday, September 9 |
| » Defeated Angels (62-72), 3-2 | Comiskey Park I (52-20) | 76-58 | |
| » Starters: Dick Lange vs Eddie Fisher | Second | 2½ out |
| » Major-league debuts: Dick Lange (Angels) |
| Sunday, September 10 |
| » Lost to Angels (63-72), 5-1 | Comiskey Park I (52-21) | 76-59 | |
| » Starters: Rudy May vs Wilbur Wood | Second | 3½ out |
| Monday, September 11 |
| » Defeated Royals (66-68), 2-1 | Municipal Stadium (1-5) | 77-59 | |
| » Starters: Tom Bradley vs Paul Splittorff | Second | 2 out |
| Tuesday, September 12 |
| » Defeated Royals (66-69), 6-0 | Municipal Stadium (2-5) | 78-59 | Won 2 |
| » Starters: Stan Bahnsen vs Monty Montgomery | Second | 2 out |
| Wednesday, September 13 |
| » Lost to Royals (67-69), 6-4 | Municipal Stadium (2-6) | 78-60 | |
| » Starters: Wilbur Wood vs Steve Busby | Second | 3 out |
| Future White Sox Nelson Cruz is born in Puerto Plata, D.R. |
| Friday, September 15 |
| » Lost to Angels (66-73), 1-0 | Anaheim Stadium (3-4) | 78-61 | Lost 2 |
| » Starters: Tom Bradley vs Rudy May | Second | 4 out |
| Saturday, September 16 |
| » Defeated Angels (66-74), 2-0 | Anaheim Stadium (4-4) | 79-61 | |
| » Starters: Stan Bahnsen vs Nolan Ryan | Second | 4 out |
| Sunday, September 17 |
| » Lost to Angels (67-74), 3-1 | Anaheim Stadium (4-5) | 79-62 | |
| » Starters: Wilbur Wood vs Andy Messersmith | Second | 5 out |
| Tuesday, September 19 |
| » Defeated Athletics (84-58), 8-7 | Oakland-Alameda County Stadium (3-5) | 80-62 | |
| » Starters: Tom Bradley vs Blue Moon Odom | Second | 4 out |
| Wednesday, September 20 |
| » Lost to Athletics (85-58), 6-3 | Oakland-Alameda County Stadium (3-6) | 80-63 | |
| » Starters: Wilbur Wood vs Ken Holtzman | Second | 5 out |
| Friday, September 22 |
| » Defeated Rangers (52-92), 8-4 | Comiskey Park I (53-21) | 81-63 | |
| » Starters: Don Stanhouse vs Stan Bahnsen | Second | 4 out |
| Saturday, September 23 |
| » Defeated Rangers (52-93), 4-3 | Comiskey Park I (54-21) | 82-63 | Won 2 |
| » Starters: Rich Hand vs Tom Bradley | Second | 4 out |
| Sunday, September 24 |
| » Defeated Rangers (52-94), 7-4 | Comiskey Park I (55-21) | 83-63 | Won 3 |
| » Starters: Bill Gogolewski vs Wilbur Wood | Second | 3½ out |
| Tuesday, September 26 |
| » Lost to Royals (73-74), 2-1 | Comiskey Park I (55-22) | 83-64 | |
| » Starters: Steve Busby vs Stan Bahnsen | Second | 4 out |
| Wednesday, September 27 |
| » Lost to Royals (74-74), 4-2 | Comiskey Park I (55-23) | 83-65 | Lost 2 |
| » Starters: Roger Nelson vs Wilbur Wood | Second | 5½ out |
| Friday, September 29 |
| » Defeated Rangers (52-98), 5-1 | Arlington Stadium (5-2) | 84-65 | |
| » Starters: Tom Bradley vs Rich Hand | Second | 5 out |
| Saturday, September 30 |
| » Defeated Rangers (52-99), 5-3 | Arlington Stadium (6-2) | 85-65 | Won 2 |
| » Starters: Stan Bahnsen vs Bill Gogolewski | Second | 5 out |
| Sunday, October 1 |
| » Lost to Rangers (53-99), 1-0 | Arlington Stadium (6-3) | 85-66 | |
| » Starters: Wilbur Wood vs Dick Bosman | Second | 6 out |
| Monday, October 2 |
| » Defeated Twins (76-76), 6-4 | Metropolitan Stadium (2-1) | 86-66 | |
| » Starters: Jim Geddes vs Dick Woodson | Second | 5½ out |
| Tuesday, October 3 |
| » Defeated Twins (76-77), 5-4 | |
