| Monday, January 17 |
| Future Red Sox Walt McKeel is born in Wilson, NC. |
| Saturday, January 29 |
| Future Red Sox Morgan Burkhart is born in St. Louis, MO. |
| Friday, February 11 |
| Future Red Sox Brian Daubach is born in Belleville, IL. |
| Monday, February 28 |
| Former Red Sox Dizzy Trout dies in Harvey, IL at the age of 57. |
| Friday, March 10 |
| Future Red Sox Rob Stanifer is born in Easley, SC. |
| Monday, March 27 |
| Future Red Sox Creighton Gubanich is born in Belleville, NJ. |
| Tuesday, April 11 |
| Future Red Sox Jason Varitek is born in Rochester, MI. |
| Saturday, April 15 |
| » Lost to Tigers (1-0), 3-2 | Tiger Stadium (0-1) | 0-1 | |
| » Starters: Marty Pattin vs Mickey Lolich | Third | 1 out |
| Monday, April 17 |
| » Lost to Indians (1-1), 4-0 | Fenway Park (0-1) | 0-2 | Lost 2 |
| » Starters: Milt Wilcox vs Ray Culp | Fourth | 2 out |
| Tuesday, April 18 |
| » Defeated Indians (1-2), 4-2 | Fenway Park (1-1) | 1-2 | |
| » Starters: Dick Tidrow vs Sonny Siebert | Fourth | 1½ out |
| » Major-league debuts: Jack Brohamer and Dick Tidrow (Indians) |
| Wednesday, April 19 |
| » Lost to Indians (2-2), 3-1 | Fenway Park (1-2) | 1-3 | |
| » Starters: Gaylord Perry vs Marty Pattin | Fifth | 2 out |
| Friday, April 21 |
| » Defeated Yankees (2-3), 5-4 | Fenway Park (2-2) | 2-3 | |
| » Starters: Mel Stottlemyre vs Ray Culp | Third | 2½ out |
| Saturday, April 22 |
| » Defeated Yankees (2-4), 11-7 | Fenway Park (3-2) | 3-3 | Won 2 |
| » Starters: Fritz Peterson vs Sonny Siebert | Third | 1½ out |
| Tuesday, April 25 |
| » Lost to Twins (4-2), 12-0 | Metropolitan Stadium (0-1) | 3-4 | |
| » Starters: Marty Pattin vs Jim Perry | Fourth | 1 out |
| » Major-league debuts: Dan Monzon (Twins) |
| Wednesday, April 26 |
| » Lost to Twins (5-2), 3-1 | Metropolitan Stadium (0-2) | 3-5 | Lost 2 |
| » Starters: Ray Culp vs Dick Woodson | Fourth | 2 out |
| Friday, April 28 |
| » Lost to Rangers (6-5), 9-6 | Arlington Stadium (0-1) | 3-6 | Lost 3 |
| » Starters: Sonny Siebert vs Pete Broberg | Fourth | 3 out |
| Saturday, April 29 |
| » Lost to Rangers (7-5), 7-6 | Arlington Stadium (0-2) | 3-7 | Lost 4 |
| » Starters: Luis Tiant vs Bill Gogolewski | Fourth | 4 out |
| Sunday, April 30 |
| » Defeated Rangers (7-6), 3-0 | Arlington Stadium (1-2) | 4-7 | |
| » Starters: Lew Krausse vs Jim Shellenback | Fourth | 3 out |
| Friday, May 5 |
| » Lost to Twins (10-3), 5-2 | Fenway Park (3-3) | 4-8 | |
| » Starters: Jim Kaat vs Ray Culp | Fifth | 3½ out |
| Saturday, May 6 |
| » Lost to Twins (11-3), 3-2 | Fenway Park (3-4) | 4-9 | Lost 2 |
| » Starters: Jim Perry vs Sonny Siebert | Fourth | 4 out |
| Sunday, May 7 |
| » Lost to Twins (12-3), 8-4 | Fenway Park (3-5) | 4-10 | Lost 3 |
| » Starters: Dick Woodson vs Luis Tiant | Fourth | 5 out |
| Tuesday, May 9 |
| » Defeated Angels (7-11), 4-3 | Anaheim Stadium (1-0) | 5-10 | |
| » Starters: Lew Krausse vs Clyde Wright | Fourth | 5 out |
| Wednesday, May 10 |
| » Lost to Angels (8-11), 5-1 | Anaheim Stadium (1-1) | 5-11 | |
| » Starters: Marty Pattin vs Nolan Ryan | Fourth | 5½ out |
| Future Red Sox Marino Santana is born in San Jose de los Llanos, D.R. |
| Thursday, May 11 |
| » Defeated Angels (8-12), 8-1 | Anaheim Stadium (2-1) | 6-11 | |
| » Starters: Ray Culp vs Andy Messersmith | Fourth | 5 out |
| Friday, May 12 |
| » Defeated Athletics (12-6), 7-6 | Oakland-Alameda County Stadium (1-0) | 7-11 | Won 2 |
| » Starters: Sonny Siebert vs Denny McLain | Fourth | 4 out |
| Saturday, May 13 |
| » Defeated Athletics (12-7), 9-6 | Oakland-Alameda County Stadium (2-0) | 8-11 | Won 3 |
| » Starters: Lew Krausse vs Ken Holtzman | Fourth | 4 out |
| Sunday, May 14 |
| » Lost to Athletics (13-7), 6-5 | Oakland-Alameda County Stadium (2-1) | 8-12 | |
| » Starters: Marty Pattin vs Catfish Hunter | Fourth | 5 out |
| Tuesday, May 16 |
| » Defeated Brewers (6-15), 5-1 | County Stadium (1-0) | 9-12 | |
| » Starters: Ray Culp vs Ken Brett | Fourth | 4 out |
| Wednesday, May 17 |
| » Lost to Brewers (7-15), 4-1 | County Stadium (1-1) | 9-13 | |
| » Starters: Sonny Siebert vs Jim Lonborg | Fourth | 5 out |
| » Major-league debuts: Bob Gallagher (Red Sox) |
| Thursday, May 18 |
| » Lost to Tigers (15-10), 7-2 | Tiger Stadium (0-2) | 9-14 | Lost 2 |
| » Starters: Lew Krausse vs Joe Coleman | Fourth | 5½ out |
| Friday, May 19 |
| » Lost to Yankees (10-15), 6-0 | Yankee Stadium (0-1) | 9-15 | Lost 3 |
| » Starters: Marty Pattin vs Mel Stottlemyre | Fifth | 6½ out |
| Sunday, May 21 |
| » Lost to Yankees (11-15), 6-3 | Yankee Stadium (0-2) | 9-16 | Lost 4 |
| » Starters: Ray Culp vs Fritz Peterson | Fifth | 7½ out |
| » Lost to Yankees (12-15), 3-2 | Yankee Stadium (0-3) | 9-17 | Lost 5 |
| » Starters: Gary Peters vs Mike Kekich | Fifth | 7½ out |
| Tuesday, May 23 |
| » Defeated Orioles (15-14), 6-5 | Fenway Park (4-5) | 10-17 | |
| » Starters: Dave McNally vs Sonny Siebert | Fifth | 7½ out |
| Wednesday, May 24 |
| » Lost to Orioles (16-14), 4-1 | Fenway Park (4-6) | 10-18 | |
| » Starters: Jim Palmer vs Lew Krausse | Fifth | 7½ out |
| Thursday, May 25 |
| » Defeated Orioles (16-15), 2-1 | Fenway Park (5-6) | 11-18 | |
| » Starters: Pat Dobson vs Marty Pattin | Fifth | 6½ out |
| Friday, May 26 |
| » Defeated Brewers (10-19), 5-4 | Fenway Park (6-6) | 12-18 | Won 2 |
| » Starters: Ken Brett vs Ray Culp | Fifth | 5½ out |
| Saturday, May 27 |
| » Defeated Brewers (10-20), 9-3 | Fenway Park (7-6) | 13-18 | Won 3 |
| » Starters: Jim Slaton vs Sonny Siebert | Fifth | 5 out |
| Sunday, May 28 |
| » Defeated Brewers (10-21), 4-1 | Fenway Park (8-6) | 14-18 | Won 4 |
| » Starters: Jim Lonborg vs Lew Krausse | Fourth | 5 out |
| Monday, May 29 |
| » Lost to Brewers (11-21), 11-3 | Fenway Park (8-7) | 14-19 | |
| » Starters: Bill Parsons vs Marty Pattin | Fifth | 5 out |
| Former Red Sox Moe Berg dies in Belleville, NJ at the age of 71. |
| Tuesday, May 30 |
| » Defeated Orioles (20-16), 6-0 | Memorial Stadium (1-0) | 15-19 | |
| » Starters: Ray Culp vs Mike Cuellar | Fourth | 4 out |
| Thursday, June 1 |
| » Defeated Orioles (20-17), 7-1 | Memorial Stadium (2-0) | 16-19 | Won 2 |
| » Starters: Sonny Siebert vs Dave McNally | Fourth | 3½ out |
| Friday, June 2 |
| » Lost to Royals (15-24), 9-1 | Municipal Stadium (0-1) | 16-20 | |
| » Starters: Lew Krausse vs Dick Drago | Fourth | 4½ out |
| Saturday, June 3 |
| » Lost to Royals (16-24), 10-4 | Municipal Stadium (0-2) | 16-21 | Lost 2 |
| » Starters: Marty Pattin vs Paul Splittorff | Fifth | 5½ out |
| Sunday, June 4 |
| » Lost to Royals (17-24), 7-5 | Municipal Stadium (0-3) | 16-22 | Lost 3 |
| » Starters: Ray Culp vs Jim Rooker | Fourth | 6 out |
| » Defeated Royals (17-25), 4-0 | Municipal Stadium (1-3) | 17-22 | |
| » Starters: John Curtis vs Mike Hedlund | Fourth | 6 out |
| Tuesday, June 6 |
| » Defeated White Sox (25-18), 2-0 | Comiskey Park I (1-0) | 18-22 | Won 2 |
| » Starters: Sonny Siebert vs Wilbur Wood | Fourth | 5½ out |
| Former Red Sox Topper Rigney dies in San Antonio, TX at the age of 76. |
| Wednesday, June 7 |
| » Lost to White Sox (26-18), 2-1 | Comiskey Park I (1-1) | 18-23 | |
| » Starters: Luis Tiant vs Stan Bahnsen | Fourth | 5½ out |
| Friday, June 9 |
| » Defeated Angels (22-26), 6-5 | Fenway Park (9-7) | 19-23 | |
| » Starters: Rickey Clark vs Marty Pattin | Fourth | 4½ out |
| Saturday, June 10 |
| » Lost to Angels (23-26), 7-3 | Fenway Park (9-8) | 19-24 | |
| » Starters: Clyde Wright vs John Curtis | Fourth | 4½ out |
| Sunday, June 11 |
| » Defeated Angels (23-27), 8-4 | Fenway Park (10-8) | 20-24 | |
| » Starters: Nolan Ryan vs Sonny Siebert | Fourth | 4½ out |
| Tuesday, June 13 |
| » Lost to Royals (22-27), 4-2 | Fenway Park (10-9) | 20-25 | |
| » Starters: Paul Splittorff vs Marty Pattin | Third | 5 out |
| Wednesday, June 14 |
| » Defeated Royals (22-28), 11-3 | Fenway Park (11-9) | 21-25 | |
| » Starters: Jim Rooker vs John Curtis | Third | 5 out |
| Thursday, June 15 |
| » Lost to Royals (23-28), 13-9 | Fenway Park (11-10) | 21-26 | |
| » Starters: Tom Murphy vs Sonny Siebert | Third | 5½ out |
| » Major-league debuts: Don Newhauser (Red Sox) |
| Saturday, June 17 |
| » Lost to White Sox (32-20), 5-4 | Fenway Park (11-11) | 21-27 | Lost 2 |
| » Starters: Wilbur Wood vs Ray Culp | Fourth | 6½ out |
| » Defeated White Sox (32-21), 10-8 | Fenway Park (12-11) | 22-27 | |
| » Starters: Tom Bradley vs Marty Pattin | Fourth | 6½ out |
| Sunday, June 18 |
| » Lost to White Sox (33-21), 8-4 | Fenway Park (12-12) | 22-28 | |
| » Starters: Stan Bahnsen vs John Curtis | Fifth | 7½ out |
| Monday, June 19 |
| » Defeated Rangers (23-33), 12-0 | Fenway Park (13-12) | 23-28 | |
| » Starters: Pete Broberg vs Sonny Siebert | Fourth | 6½ out |
| Tuesday, June 20 |
| » Lost to Rangers (24-33), 5-2 | Fenway Park (13-13) | 23-29 | |
| » Starters: Rich Hand vs Marty Pattin | Third | 6½ out |
| Wednesday, June 21 |
| » Defeated Rangers (24-34), 10-9 | Fenway Park (14-13) | 24-29 | |
| » Starters: Bill Gogolewski vs Ray Culp | Fourth | 6½ out |
| Friday, June 23 |
| » Lost to Brewers (19-36), 8-1 | County Stadium (1-2) | 24-30 | |
| » Starters: John Curtis vs Ken Brett | Fourth | 7 out |
| Saturday, June 24 |
| » Lost to Brewers (20-36), 5-2 | County Stadium (1-3) | 24-31 | Lost 2 |
| » Starters: Sonny Siebert vs Jim Lonborg | Fourth | 7½ out |
| Sunday, June 25 |
| » Defeated Brewers (20-37), 8-1 | County Stadium (2-3) | 25-31 | |
| » Starters: Marty Pattin vs Bill Parsons | Third | 7 out |
| » Lost to Brewers (21-37), 2-0 | County Stadium (2-4) | 25-32 | |
| » Starters: Lynn McGlothen vs Earl Stephenson | Third | 7 out |
| » Major-league debuts: Lynn McGlothen (Red Sox) |
| Monday, June 26 |
| » Lost to Indians (27-31), 7-3 | Cleveland Stadium (0-1) | 25-33 | Lost 2 |
| » Starters: Ray Culp vs Ray Lamb | Fifth | 8 out |
| Tuesday, June 27 |
| » Defeated Indians (27-32), 8-2 | Cleveland Stadium (1-1) | 26-33 | |
| » Starters: John Curtis vs Vince Colbert | Fourth | 8 out |
| Wednesday, June 28 |
| » Defeated Tigers (35-27), 5-3 | Fenway Park (15-13) | 27-33 | Won 2 |
| » Starters: Joe Coleman vs Sonny Siebert | Third | 7 out |
| Thursday, June 29 |
| » Lost to Tigers (36-27), 8-4 | Fenway Park (15-14) | 27-34 | |
| » Starters: Tom Timmermann vs Lynn McGlothen | Third | 8 out |
| Saturday, July 1 |
| » Defeated Brewers (26-38), 5-4 | Fenway Park (16-14) | 28-34 | |
| » Starters: Bill Parsons vs Marty Pattin | Fourth | 7½ out |
| Sunday, July 2 |
| » Defeated Brewers (26-39), 15-4 | Fenway Park (17-14) | 29-34 | Won 2 |
| » Starters: Skip Lockwood vs Ray Culp | Fourth | 6 out |
| » Defeated Brewers (26-40), 3-2 | Fenway Park (18-14) | 30-34 | Won 3 |
| » Starters: Gary Ryerson vs John Curtis | Fourth | 6 out |
| Former Red Sox Rankin Johnson dies in Williamsport, PA at the age of 85. |
| Monday, July 3 |
| » Defeated Twins (36-32), 8-2 | Fenway Park (19-14) | 31-34 | Won 4 |
| » Starters: Bert Blyleven vs Luis Tiant | Second | 5 out |
| Tuesday, July 4 |
| » Defeated Twins (36-33), 2-0 | Fenway Park (20-14) | 32-34 | Won 5 |
| » Starters: Ray Corbin vs Lynn McGlothen | Third | 5 out |
| Wednesday, July 5 |
| » Defeated Twins (36-34), 2-0 | Fenway Park (21-14) | 33-34 | Won 6 |
| » Starters: Jim Perry vs Marty Pattin | Third | 5 out |
| Friday, July 7 |
| » Defeated Angels (33-42), 5-3 | Anaheim Stadium (3-1) | 34-34 | Won 7 |
| » Starters: John Curtis vs Rudy May | Third | 4½ out |
| Saturday, July 8 |
| » Lost to Angels (34-42), 4-3 | Anaheim Stadium (3-2) | 34-35 | |
| » Starters: Ray Culp vs Lloyd Allen | Third | 4 out |
| Sunday, July 9 |
| » Lost to Angels (35-42), 3-0 | Anaheim Stadium (3-3) | 34-36 | Lost 2 |
| » Starters: Sonny Siebert vs Nolan Ryan | Third | 4 out |
| Monday, July 10 |
| » Defeated Athletics (48-28), 4-2 | Oakland-Alameda County Stadium (3-1) | 35-36 | |
| » Starters: Lynn McGlothen vs Ken Holtzman | Third | 4 out |
| Tuesday, July 11 |
| » Defeated Athletics (48-29), 4-0 | Oakland-Alameda County Stadium (4-1) | 36-36 | Won 2 |
| » Starters: Marty Pattin vs Joe Horlen | Third | 4 out |
| Wednesday, July 12 |
| » Defeated Athletics (48-30), 7-6 | Oakland-Alameda County Stadium (5-1) | 37-36 | Won 3 |
| » Starters: John Curtis vs Dave Hamilton | Third | 4 out |
| Thursday, July 13 |
| » Lost to Twins (40-37), 10-0 | Metropolitan Stadium (0-3) | 37-37 | |
| » Starters: Ray Culp vs Ray Corbin | Third | 5 out |
| Friday, July 14 |
| » Lost to Twins (41-37), 7-6 | Metropolitan Stadium (0-4) | 37-38 | Lost 2 |
| » Starters: Sonny Siebert vs Jim Perry | Third | 5 out |
| Saturday, July 15 |
| » Lost to Twins (42-37), 7-1 | Metropolitan Stadium (0-5) | 37-39 | Lost 3 |
| » Starters: Lynn McGlothen vs Dick Woodson | Third | 6 out |
| Sunday, July 16 |
| » Defeated Twins (42-38), 6-1 | Metropolitan Stadium (1-5) | 38-39 | |
| » Starters: Marty Pattin vs Bert Blyleven | Third | 6 out |
| Monday, July 17 |
| » Defeated Angels (38-47), 4-1 | Fenway Park (22-14) | 39-39 | Won 2 |
| » Starters: Steve Barber vs John Curtis | Third | 6 out |
| Tuesday, July 18 |
| » Defeated Angels (38-48), 4-1 | Fenway Park (23-14) | 40-39 | Won 3 |
| » Starters: Nolan Ryan vs Sonny Siebert | Third | 6 out |
| Wednesday, July 19 |
| » Defeated Angels (38-49), 8-2 | Fenway Park (24-14) | 41-39 | Won 4 |
| » Starters: Clyde Wright vs Lynn McGlothen | Third | 5 out |
| Thursday, July 20 |
| » Defeated Athletics (54-32), 2-1 | Fenway Park (25-14) | 42-39 | Won 5 |
| » Starters: Ken Holtzman vs Marty Pattin | Third | 4½ out |
| » Defeated Athletics (54-33), 4-3 | Fenway Park (26-14) | 43-39 | Won 6 |
| » Starters: Vida Blue vs Gary Peters | Third | 4½ out |
| Friday, July 21 |
| » Defeated Athletics (54-34), 5-4 | Fenway Park (27-14) | 44-39 | Won 7 |
| » Starters: Dave Hamilton vs John Curtis | Third | 4½ out |
| Saturday, July 22 |
| » Lost to Athletics (55-34), 5-3 | Fenway Park (27-15) | 44-40 | |
| » Starters: Catfish Hunter vs Luis Tiant | Third | 5 out |
| » Defeated Athletics (55-35), 3-0 | Fenway Park (28-15) | 45-40 | |
| » Starters: Joe Horlen vs Sonny Siebert | Third | 5 out |
| Sunday, July 23 |
| » Lost to Athletics (56-35), 6-3 | Fenway Park (28-16) | 45-41 | |
| » Starters: Blue Moon Odom vs Lynn McGlothen | Third | 5 out |
| Thursday, July 27 |
| » Lost to Yankees (43-43), 6-2 | Yankee Stadium (0-4) | 45-42 | Lost 2 |
| » Starters: Marty Pattin vs Fritz Peterson | Third | 6½ out |
| Friday, July 28 |
| » Defeated Yankees (43-44), 6-5 | Yankee Stadium (1-4) | 46-42 | |
| » Starters: Gary Peters vs Mel Stottlemyre | Third | 6 out |
| » Lost to Yankees (44-44), 3-1 | Yankee Stadium (1-5) | 46-43 | |
| » Starters: Sonny Siebert vs Steve Kline | Third | 6 out |
| Saturday, July 29 |
| » Lost to Yankees (45-44), 8-1 | Yankee Stadium (1-6) | 46-44 | Lost 2 |
| » Starters: John Curtis vs Mike Kekich | Third | 6 out |
| Sunday, July 30 |
| » Defeated Tigers (53-40), 4-3 | Tiger Stadium (1-2) | 47-44 | |
| » Starters: Lynn McGlothen vs Chuck Seelbach | Third | 6 out |
| » Lost to Tigers (54-40), 7-2 | Tiger Stadium (1-3) | 47-45 | |
| » Starters: Luis Tiant vs Joe Niekro | Third | 6 out |
| Monday, July 31 |
| » Lost to Tigers (55-40), 5-2 | Tiger Stadium (1-4) | 47-46 | Lost 2 |
| » Starters: Marty Pattin vs Mickey Lolich | Fourth | 7 out |
| Tuesday, August 1 |
| » Lost to Yankees (48-45), 10-4 | Fenway Park (28-17) | 47-47 | Lost 3 |
| » Starters: Mel Stottlemyre vs Sonny Siebert | Fourth | 7 out |
| Wednesday, August 2 |
| » Lost to Yankees (49-45), 5-1 | Fenway Park (28-18) | 47-48 | Lost 4 |
| » Starters: Steve Kline vs John Curtis | Fourth | 6½ out |
| » Defeated Yankees (49-46), 7-4 | Fenway Park (29-18) | 48-48 | |
| » Starters: Mike Kekich vs Gary Peters | Fourth | 6½ out |
| Thursday, August 3 |
| » Defeated Yankees (49-47), 7-2 | Fenway Park (30-18) | 49-48 | Won 2 |
| » Starters: Ron Klimkowski vs Lynn McGlothen | Fourth | 5½ out |
| Friday, August 4 |
| » Defeated Orioles (53-46), 2-0 | Fenway Park (31-18) | 50-48 | Won 3 |
| » Starters: Pat Dobson vs Marty Pattin | Fourth | 4½ out |
| Saturday, August 5 |
| » Defeated Orioles (53-47), 6-3 | Fenway Park (32-18) | 51-48 | Won 4 |
| » Starters: Dave McNally vs Luis Tiant | Third | 4½ out |
| Future Red Sox John Wasdin is born in Fort Belvoir, VA. |
| Sunday, August 6 |
| » Lost to Orioles (54-47), 11-2 | Fenway Park (32-19) | 51-49 | |
| » Starters: Jim Palmer vs John Curtis | Fourth | 5 out |
| Monday, August 7 |
| » Lost to Indians (48-55), 6-2 | Fenway Park (32-20) | 51-50 | Lost 2 |
| » Starters: Tom Hilgendorf vs Lynn McGlothen | Fourth | 5½ out |
| Future Red Sox Kerry Lacy is born in Chattanooga, TN. |
| Tuesday, August 8 |
| » Defeated Indians (48-56), 4-1 | Fenway Park (33-20) | 52-50 | |
| » Starters: Dick Tidrow vs Marty Pattin | Fourth | 4½ out |
| Wednesday, August 9 |
| » Defeated Indians (48-57), 5-2 | Fenway Park (34-20) | 53-50 | Won 2 |
| » Starters: Gaylord Perry vs Sonny Siebert | Fourth | 4 out |
| Friday, August 11 |
| » Lost to Orioles (58-48), 2-1 | Memorial Stadium (2-1) | 53-51 | |
| » Starters: Lynn McGlothen vs Mike Cuellar | Fourth | 4 out |
| Saturday, August 12 |
| » Lost to Orioles (59-48), 3-2 | Memorial Stadium (2-2) | 53-52 | Lost 2 |
| » Starters: Marty Pattin vs Pat Dobson | Fourth | 4 out |
| » Defeated Orioles (59-49), 5-3 | Memorial Stadium (3-2) | 54-52 | |
| » Starters: Luis Tiant vs Doyle Alexander | Fourth | 4 out |
| Sunday, August 13 |
| » Lost to Orioles (60-49), 8-2 | Memorial Stadium (3-3) | 54-53 | |
| » Starters: Sonny Siebert vs Dave McNally | Fourth | 5 out |
| Tuesday, August 15 |
| » Defeated Rangers (44-66), 3-0 | Arlington Stadium (2-2) | 55-53 | |
| » Starters: John Curtis vs Don Stanhouse | Fourth | 4 out |
| Wednesday, August 16 |
| » Lost to Rangers (45-66), 9-8 | Arlington Stadium (2-3) | 55-54 | |
| » Starters: Lynn McGlothen vs Rich Hand | Fourth | 4 out |
| Thursday, August 17 |
| » Defeated Rangers (45-67), 4-3 | Arlington Stadium (3-3) | 56-54 | |
| » Starters: Marty Pattin vs Mike Paul | Fourth | 3 out |
| Friday, August 18 |
| » Lost to White Sox (66-46), 8-1 | Comiskey Park I (1-2) | 56-55 | |
| » Starters: Sonny Siebert vs Stan Bahnsen | Fourth | 3½ out |
| Saturday, August 19 |
| » Defeated White Sox (66-47), 3-0 | Comiskey Park I (2-2) | 57-55 | |
| » Starters: Luis Tiant vs Tom Bradley | Fourth | 3½ out |
| Sunday, August 20 |
| » Lost to White Sox (67-47), 9-7 | Comiskey Park I (2-3) | 57-56 | |
| » Starters: Lynn McGlothen vs Wilbur Wood | Fourth | 4 out |
| » Defeated White Sox (67-48), 5-4 | Comiskey Park I (3-3) | 58-56 | |
| » Starters: John Curtis vs Eddie Fisher | Fourth | 4 out |
| Tuesday, August 22 |
| » Defeated Royals (55-59), 10-7 | Municipal Stadium (2-3) | 59-56 | Won 2 |
| » Starters: Marty Pattin vs Mike Hedlund | Fourth | 2½ out |
| Wednesday, August 23 |
| » Lost to Royals (56-59), 3-0 | Municipal Stadium (2-4) | 59-57 | |
| » Starters: Sonny Siebert vs Roger Nelson | Fourth | 3½ out |
| Friday, August 25 |
| » Defeated Rangers (48-71), 4-0 | Fenway Park (35-20) | 60-57 | |
| » Starters: Don Stanhouse vs Luis Tiant | Third | 3 out |
| Saturday, August 26 |
| » Defeated Rangers (48-72), 7-6 | Fenway Park (36-20) | 61-57 | Won 2 |
| » Starters: Bill Gogolewski vs Lynn McGlothen | Second | 3 out |
| Former Red Sox Danny MacFayden dies in Brunswick, ME at the age of 68. |
| Sunday, August 27 |
| » Defeated Rangers (48-73), 10-3 | Fenway Park (37-20) | 62-57 | Won 3 |
| » Starters: Rich Hand vs Marty Pattin | Fourth | 3½ out |
| Monday, August 28 |
| » Lost to White Sox (71-50), 6-4 | Fenway Park (37-21) | 62-58 | |
| » Starters: Dave Lemonds vs Sonny Siebert | Fourth | 4 out |
| Tuesday, August 29 |
| » Defeated White Sox (71-51), 3-0 | Fenway Park (38-21) | 63-58 | |
| » Starters: Tom Bradley vs Luis Tiant | Second | 3 out |
| Former Red Sox Clem Hausmann dies in Baytown, TX at the age of 54. |
| Wednesday, August 30 |
| » Defeated White Sox (71-52), 4-2 | Fenway Park (39-21) | 64-58 | Won 2 |
| » Starters: Wilbur Wood vs Lynn McGlothen | Second | 2 out |
| Friday, September 1 |
| » Defeated Royals (60-64), 1-0 | Fenway Park (40-21) | 65-58 | Won 3 |
| » Starters: Dick Drago vs Marty Pattin | Third | 2 out |
| » Major-league debuts: Jim Wohlford (Royals) |
| Saturday, September 2 |
| » Defeated Royals (60-65), 5-3 | Fenway Park (41-21) | 66-58 | Won 4 |
| » Starters: Mike Hedlund vs Sonny Siebert | Third | 1 out |
| Former Red Sox Jim Brillheart dies in Radford, VA at the age of 69. |
| Monday, September 4 |
| » Defeated Brewers (51-77), 2-0 | County Stadium (3-4) | 67-58 | Won 5 |
| » Starters: Luis Tiant vs Jim Lonborg | Second | 1½ out |
| » Lost to Brewers (52-77), 6-2 | County Stadium (3-5) | 67-59 | |
| » Starters: Lynn McGlothen vs Ken Brett | Second | 1½ out |
| Tuesday, September 5 |
| » Defeated Brewers (52-78), 5-3 | County Stadium (4-5) | 68-59 | |
| » Starters: Marty Pattin vs Skip Lockwood | Second | 1½ out |
| Wednesday, September 6 |
| » Defeated Yankees (70-62), 2-0 | Fenway Park (42-21) | 69-59 | Won 2 |
| » Starters: Mel Stottlemyre vs John Curtis | Second | 1½ out |
| Former Red Sox Charlie Berry dies in Evanston, IL at the age of 70. |
| Thursday, September 7 |
| » Defeated Yankees (70-63), 10-4 | Fenway Park (43-21) | 70-59 | Won 3 |
| » Starters: Steve Kline vs Sonny Siebert | First | -- |
| Friday, September 8 |
| » Defeated Yankees (70-64), 4-2 | Fenway Park (44-21) | 71-59 | Won 4 |
| » Starters: Fritz Peterson vs Luis Tiant | First | -- |
| Saturday, September 9 |
| » Lost to Indians (62-71), 2-1 | Cleveland Stadium (1-2) | 71-60 | |
| » Starters: Lynn McGlothen vs Gaylord Perry | First | -- |
| Sunday, September 10 |
| » Defeated Indians (62-72), 5-1 | Cleveland Stadium (2-2) | 72-60 | |
| » Starters: Marty Pattin vs Marcelino Lopez | First | -- |
| » Defeated Indians (62-73), 2-0 | Cleveland Stadium (3-2) | 73-60 | Won 2 |
| » Starters: John Curtis vs Steve Dunning | First | -- |
| Monday, September 11 |
| » Lost to Indians (63-73), 6-5 | Cleveland Stadium (3-3) | 73-61 | |
| » Starters: Sonny Siebert vs Dick Tidrow | First | -- |
| Tuesday, September 12 |
| » Lost to Yankees (74-64), 3-2 | Yankee Stadium (1-7) | 73-62 | Lost 2 |
| » Starters: Luis Tiant vs Fritz Peterson | First | -- |
| Wednesday, September 13 |
| » Defeated Yankees (74-65), 7-2 | Yankee Stadium (2-7) | 74-62 | |
| » Starters: Lynn McGlothen vs Rob Gardner | First | -- |
| Friday, September 15 |
| » Defeated Indians (63-78), 4-3 | Fenway Park (45-21) | 75-62 | Won 2 |
| » Starters: Steve Dunning vs Marty Pattin | First | -- |
| Saturday, September 16 |
| » Defeated Indians (63-79), 10-0 | Fenway Park (46-21) | 76-62 | Won 3 |
| » Starters: Dick Tidrow vs Luis Tiant | First | -- |
| » Major-league debuts: Dwight Evans (Red Sox) |
| Sunday, September 17 |
| » Lost to Indians (64-79), 9-2 | Fenway Park (46-22) | 76-63 | |
| » Starters: Gaylord Perry vs John Curtis | First | -- |
| Monday, September 18 |
| » Lost to Orioles (77-66), 5-2 | Fenway Park (46-23) | 76-64 | Lost 2 |
| » Starters: Pat Dobson vs Lynn McGlothen | Second | ½ out |
| Wednesday, September 20 |
| » Defeated Orioles (77-67), 9-1 | Fenway Park (47-23) | 77-64 | |
| » Starters: Jim Palmer vs Marty Pattin | First | -- |
| » Defeated Orioles (77-68), 4-0 | Fenway Park (48-23) | 78-64 | Won 2 |
| » Starters: Mike Cuellar vs Luis Tiant | First | -- |
| Thursday, September 21 |
| » Lost to Tigers (79-66), 10-3 | Fenway Park (48-24) | 78-65 | |
| » Starters: Joe Coleman vs Mike Garman | Second | 1 out |
| Friday, September 22 |
| » Defeated Tigers (79-67), 3-2 | Fenway Park (49-24) | 79-65 | |
| » Starters: Chris Zachary vs Lynn McGlothen | First | -- |
| Saturday, September 23 |
| » Lost to Tigers (80-67), 7-1 | Fenway Park (49-25) | 79-66 | |
| » Starters: Mickey Lolich vs Sonny Siebert | First | -- |
| Sunday, September 24 |
| » Defeated Tigers (80-68), 7-2 | Fenway Park (50-25) | 80-66 | |
| » Starters: Woodie Fryman vs Luis Tiant | First | -- |
| Tuesday, September 26 |
| » Lost to Brewers (62-87), 6-4 | Fenway Park (50-26) | 80-67 | |
| » Starters: Bill Parsons vs Marty Pattin | First | -- |
| Wednesday, September 27 |
| » Defeated Brewers (62-88), 7-5 | Fenway Park (51-26) | 81-67 | |
| » Starters: Ken Brett vs Lynn McGlothen | First | -- |
| Thursday, September 28 |
| » Defeated Royals (74-75), 3-1 | Fenway Park (52-26) | 82-67 | Won 2 |
| » Starters: Dick Drago vs John Curtis | First | -- |
| Friday, September 29 |
| » Defeated Orioles (78-72), 4-2 | Memorial Stadium (4-3) | 83-67 | Won 3 |
| » Starters: Luis Tiant vs Jim Palmer | First | -- |
| Saturday, September 30 |
| » Defeated Orioles (78-73), 3-1 | Memorial Stadium (5-3) | 84-67 | Won 4 |
| » Starters: Marty Pattin vs Pat Dobson | First | -- |
| Sunday, October 1 |
| » Lost to Orioles (79-73), 2-1 | Memorial Stadium (5-4) | 84-68 | |
| » Starters: Lynn McGlothen vs Mike Cuellar | First | -- |
| Monday, October 2 |
| » Lost to Tigers (85-69), 4-1 | Tiger Stadium (1-5) | 84-69 | Lost 2 |
| » Starters: John Curtis vs Mickey Lolich | Second | ½ out |
| Tuesday, October 3 |
| » Lost to Tigers (86-69), 3-1 | Tiger Stadium (1-6) | 84-70 | Lost 3 |
| » Starters: Luis Tiant vs Woodie Fryman | Second | 1½ out |
| Wednesday, October 4 |
| » Defeated Tigers (86-70), 4-1 | Tiger Stadium (2-6) | 85-70 | |
| » Starters: Marty Pattin vs Joe Coleman | Second | ½ out |
| » Major-league debuts: Vic Correll (Red Sox) |
| Thursday, October 19 |
| Future Red Sox Keith Foulke is born in Ellsworth AFB, SD. |
| Friday, October 20 |
| Former Red Sox Allan Russell dies in Baltimore, MD at the age of 80. |
| Thursday, November 2 |
| Former Red Sox Freddy Parent dies in Sanford, ME at the age of 97. |
| Monday, December 11 |
| Future Red Sox Frankie Rodriguez is born in Brooklyn, NY. |
| Thursday, December 14 |
| Future Red Sox Marcus Jensen is born in Oakland, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |