| Thursday, January 13 |
| Future Padre Akinori Otsuka is born in Chiba, Japan. |
| Sunday, March 12 |
| Future Padre George Arias is born in Tucson, AZ. |
| Saturday, April 15 |
| » Defeated Braves (0-1), 6-5 | San Diego/Jack Murphy Stadium (1-0) | 1-0 | |
| » Starters: Phil Niekro vs Clay Kirby | First | -- |
| Sunday, April 16 |
| » Lost to Braves (1-1), 5-1 | San Diego/Jack Murphy Stadium (1-1) | 1-1 | |
| » Starters: Ron Reed vs Steve Arlin | Second | ½ out |
| » Defeated Braves (1-2), 3-0 | San Diego/Jack Murphy Stadium (2-1) | 2-1 | |
| » Starters: Pat Jarvis vs Bill Greif | Second | ½ out |
| » Major-league debuts: Ron Schueler (Braves) |
| Tuesday, April 18 |
| » Lost to Giants (3-1), 5-1 | San Diego/Jack Murphy Stadium (2-2) | 2-2 | |
| » Starters: Don Carrithers vs Tom Phoebus | Second | 1 out |
| Wednesday, April 19 |
| » Defeated Giants (3-2), 4-3 | San Diego/Jack Murphy Stadium (3-2) | 3-2 | |
| » Starters: Juan Marichal vs Clay Kirby | Second | 1 out |
| Thursday, April 20 |
| » Lost to Giants (4-2), 2-1 | San Diego/Jack Murphy Stadium (3-3) | 3-3 | |
| » Starters: Sam McDowell vs Steve Arlin | Fourth | 2 out |
| Friday, April 21 |
| » Lost to Dodgers (6-1), 12-2 | Dodger Stadium (0-1) | 3-4 | Lost 2 |
| » Starters: Bill Greif vs Al Downing | Fourth | 3 out |
| Saturday, April 22 |
| » Lost to Dodgers (7-1), 1-0 | Dodger Stadium (0-2) | 3-5 | Lost 3 |
| » Starters: Fred Norman vs Bill Singer | Fourth | 4 out |
| Sunday, April 23 |
| » Defeated Dodgers (7-2), 2-1 | Dodger Stadium (1-2) | 4-5 | |
| » Starters: Clay Kirby vs Tommy John | Third | 3 out |
| Tuesday, April 25 |
| » Lost to Mets (5-2), 2-1 | San Diego/Jack Murphy Stadium (3-4) | 4-6 | |
| » Starters: Buzz Capra vs Steve Arlin | Second | 4 out |
| Wednesday, April 26 |
| » Lost to Mets (6-2), 5-1 | San Diego/Jack Murphy Stadium (3-5) | 4-7 | Lost 2 |
| » Starters: Tom Seaver vs Bill Greif | Third | 5 out |
| Thursday, April 27 |
| » Lost to Mets (7-2), 4-3 | San Diego/Jack Murphy Stadium (3-6) | 4-8 | Lost 3 |
| » Manager: Don Zimmer |
| » Starters: Gary Gentry vs Fred Norman | Fifth | 5½ out |
| Friday, April 28 |
| » Lost to Phillies (7-4), 3-0 | San Diego/Jack Murphy Stadium (3-7) | 4-9 | Lost 4 |
| » Starters: Woodie Fryman vs Clay Kirby | Fifth | 5½ out |
| Saturday, April 29 |
| » Defeated Phillies (7-5), 4-0 | San Diego/Jack Murphy Stadium (4-7) | 5-9 | |
| » Starters: Steve Carlton vs Steve Arlin | Fifth | 5 out |
| Sunday, April 30 |
| » Lost to Phillies (8-5), 6-1 | San Diego/Jack Murphy Stadium (4-8) | 5-10 | |
| » Starters: Barry Lersch vs Bill Greif | Sixth | 6½ out |
| » Lost to Phillies (9-5), 3-1 | San Diego/Jack Murphy Stadium (4-9) | 5-11 | Lost 2 |
| » Starters: Bill Champion vs Mike Corkins | Sixth | 6½ out |
| Tuesday, May 2 |
| » Defeated Expos (9-5), 6-1 | San Diego/Jack Murphy Stadium (5-9) | 6-11 | |
| » Starters: Steve Renko vs Fred Norman | Fifth | 6 out |
| Wednesday, May 3 |
| » Defeated Expos (9-6), 3-2 | San Diego/Jack Murphy Stadium (6-9) | 7-11 | Won 2 |
| » Starters: Mike Torrez vs Clay Kirby | Fifth | 5 out |
| Friday, May 5 |
| » Defeated Mets (11-5), 6-0 | Shea Stadium (1-0) | 8-11 | Won 3 |
| » Starters: Steve Arlin vs Jerry Koosman | Fourth | 5 out |
| Saturday, May 6 |
| » Defeated Mets (11-6), 6-2 | Shea Stadium (2-0) | 9-11 | Won 4 |
| » Starters: Bill Greif vs Tom Seaver | Third | 4 out |
| Sunday, May 7 |
| » Lost to Mets (12-6), 8-6 | Shea Stadium (2-1) | 9-12 | |
| » Starters: Fred Norman vs Gary Gentry | Third | 4½ out |
| Wednesday, May 10 |
| » Defeated Phillies (13-8), 5-3 | Veteran's Stadium (1-0) | 10-12 | |
| » Starters: Clay Kirby vs Woodie Fryman | Third | 4 out |
| Thursday, May 11 |
| » Lost to Phillies (14-8), 6-5 | Veteran's Stadium (1-1) | 10-13 | |
| » Starters: Steve Arlin vs Bill Champion | Third | 4 out |
| Friday, May 12 |
| » Defeated Expos (12-10), 5-3 | Parc Jarry (1-0) | 11-13 | |
| » Starters: Bill Greif vs Carl Morton | Third | 3½ out |
| Saturday, May 13 |
| » Defeated Expos (12-11), 5-0 | Parc Jarry (2-0) | 12-13 | Won 2 |
| » Starters: Fred Norman vs Ernie McAnally | Third | 3½ out |
| Sunday, May 14 |
| » Lost to Expos (13-11), 9-3 | Parc Jarry (2-1) | 12-14 | |
| » Starters: Clay Kirby vs Mike Torrez | Fourth | 4 out |
| Monday, May 15 |
| » Lost to Dodgers (17-10), 2-1 | San Diego/Jack Murphy Stadium (6-10) | 12-15 | Lost 2 |
| » Starters: Al Downing vs Steve Arlin | Fourth | 5 out |
| Tuesday, May 16 |
| » Lost to Dodgers (18-10), 2-0 | San Diego/Jack Murphy Stadium (6-11) | 12-16 | Lost 3 |
| » Starters: Bill Singer vs Bill Greif | Fourth | 6 out |
| Wednesday, May 17 |
| » Defeated Dodgers (18-11), 2-0 | San Diego/Jack Murphy Stadium (7-11) | 13-16 | |
| » Starters: Tommy John vs Fred Norman | Fourth | 5 out |
| Friday, May 19 |
| » Lost to Reds (17-13), 1-0 | San Diego/Jack Murphy Stadium (7-12) | 13-17 | |
| » Starters: Jim McGlothlin vs Clay Kirby | Fourth | 5½ out |
| Saturday, May 20 |
| » Defeated Reds (17-14), 5-3 | San Diego/Jack Murphy Stadium (8-12) | 14-17 | |
| » Starters: Jack Billingham vs Steve Arlin | Fourth | 5½ out |
| Sunday, May 21 |
| » Lost to Reds (18-14), 7-2 | San Diego/Jack Murphy Stadium (8-13) | 14-18 | |
| » Starters: Gary Nolan vs Bill Greif | Fourth | 5 out |
| » Defeated Reds (18-15), 7-0 | San Diego/Jack Murphy Stadium (9-13) | 15-18 | |
| » Starters: Tom Hall vs Fred Norman | Fourth | 5 out |
| Monday, May 22 |
| » Lost to Astros (20-12), 7-0 | San Diego/Jack Murphy Stadium (9-14) | 15-19 | |
| » Starters: Larry Dierker vs Ed Acosta | Fourth | 6 out |
| Tuesday, May 23 |
| » Lost to Astros (21-12), 7-0 | San Diego/Jack Murphy Stadium (9-15) | 15-20 | Lost 2 |
| » Starters: Tom Griffin vs Clay Kirby | Fourth | 8 out |
| » Lost to Astros (22-12), 2-1 | San Diego/Jack Murphy Stadium (9-16) | 15-21 | Lost 3 |
| » Starters: Ken Forsch vs Bill Greif | Fourth | 8 out |
| Wednesday, May 24 |
| » Lost to Astros (23-12), 4-2 | San Diego/Jack Murphy Stadium (9-17) | 15-22 | Lost 4 |
| » Starters: Don Wilson vs Steve Arlin | Fifth | 9 out |
| Friday, May 26 |
| » Lost to Reds (19-17), 4-0 | Riverfront Stadium (0-1) | 15-23 | Lost 5 |
| » Starters: Fred Norman vs Gary Nolan | Fifth | 10 out |
| Saturday, May 27 |
| » Lost to Reds (20-17), 9-4 | Riverfront Stadium (0-2) | 15-24 | Lost 6 |
| » Starters: Clay Kirby vs Jim McGlothlin | Fifth | 10 out |
| Sunday, May 28 |
| » Defeated Reds (20-18), 5-2 | Riverfront Stadium (1-2) | 16-24 | |
| » Starters: Steve Arlin vs Ross Grimsley | Fifth | 9 out |
| Monday, May 29 |
| » Lost to Braves (17-22), 2-1 | Atlanta-Fulton County Stadium (0-1) | 16-25 | |
| » Starters: Bill Greif vs Jim Nash | Fifth | 9 out |
| Wednesday, May 31 |
| » Lost to Braves (18-22), 5-4 | Atlanta-Fulton County Stadium (0-2) | 16-26 | Lost 2 |
| » Starters: Fred Norman vs Ron Reed | Fifth | 10 out |
| Friday, June 2 |
| » Lost to Cubs (22-18), 2-1 | San Diego/Jack Murphy Stadium (9-18) | 16-27 | Lost 3 |
| » Starters: Burt Hooton vs Clay Kirby | Fourth | 10½ out |
| Saturday, June 3 |
| » Lost to Cubs (23-18), 8-3 | San Diego/Jack Murphy Stadium (9-19) | 16-28 | Lost 4 |
| » Starters: Milt Pappas vs Steve Arlin | Fifth | 11½ out |
| Sunday, June 4 |
| » Lost to Cubs (24-18), 3-1 | San Diego/Jack Murphy Stadium (9-20) | 16-29 | Lost 5 |
| » Starters: Fergie Jenkins vs Bill Greif | Fifth | 11½ out |
| Wednesday, June 7 |
| » Lost to Pirates (28-16), 12-5 | San Diego/Jack Murphy Stadium (9-21) | 16-30 | Lost 6 |
| » Starters: Nelson Briles vs Fred Norman | Fifth | 12½ out |
| » Lost to Pirates (29-16), 1-0 | San Diego/Jack Murphy Stadium (9-22) | 16-31 | Lost 7 |
| » Starters: Dock Ellis vs Clay Kirby | Fifth | 12½ out |
| » Major-league debuts: Dave Roberts (Padres) |
| Thursday, June 8 |
| » Lost to Pirates (30-16), 11-2 | San Diego/Jack Murphy Stadium (9-23) | 16-32 | Lost 8 |
| » Starters: Bob Moose vs Steve Arlin | Fifth | 13½ out |
| Friday, June 9 |
| » Lost to Cardinals (21-28), 3-2 | San Diego/Jack Murphy Stadium (9-24) | 16-33 | Lost 9 |
| » Starters: Bob Gibson vs Bill Greif | Fifth | 14 out |
| Saturday, June 10 |
| » Lost to Cardinals (22-28), 5-2 | San Diego/Jack Murphy Stadium (9-25) | 16-34 | Lost 10 |
| » Starters: Al Santorini vs Mike Caldwell | Fifth | 14½ out |
| Sunday, June 11 |
| » Defeated Cardinals (22-29), 4-3 | San Diego/Jack Murphy Stadium (10-25) | 17-34 | |
| » Starters: Rick Wise vs Fred Norman | Fifth | 14½ out |
| Tuesday, June 13 |
| » Defeated Cubs (27-22), 4-3 | Wrigley Field (1-0) | 18-34 | Won 2 |
| » Starters: Clay Kirby vs Milt Pappas | Fifth | 15 out |
| Wednesday, June 14 |
| » Lost to Cubs (28-22), 12-9 | Wrigley Field (1-1) | 18-35 | |
| » Starters: Steve Arlin vs Fergie Jenkins | Fifth | 16 out |
| Thursday, June 15 |
| » Lost to Cubs (29-22), 10-1 | Wrigley Field (1-2) | 18-36 | Lost 2 |
| » Starters: Bill Greif vs Bill Hands | Fifth | 16½ out |
| Friday, June 16 |
| » Lost to Pirates (35-18), 2-1 | Three Rivers Stadium (0-1) | 18-37 | Lost 3 |
| » Starters: Fred Norman vs Steve Blass | Fifth | 16½ out |
| Saturday, June 17 |
| » Defeated Pirates (35-19), 4-0 | Three Rivers Stadium (1-1) | 19-37 | |
| » Starters: Clay Kirby vs Luke Walker | Fifth | 16½ out |
| Sunday, June 18 |
| » Defeated Pirates (35-20), 1-0 | Three Rivers Stadium (2-1) | 20-37 | Won 2 |
| » Starters: Steve Arlin vs Bruce Kison | Fifth | 15½ out |
| Tuesday, June 20 |
| » Lost to Cardinals (25-32), 5-4 | Busch Stadium II (0-1) | 20-38 | |
| » Starters: Fred Norman vs Rick Wise | Fifth | 15½ out |
| Wednesday, June 21 |
| » Lost to Cardinals (26-32), 14-3 | Busch Stadium II (0-2) | 20-39 | Lost 2 |
| » Starters: Clay Kirby vs Bob Gibson | Fifth | 16 out |
| Friday, June 23 |
| » Defeated Giants (22-45), 4-1 | San Diego/Jack Murphy Stadium (11-25) | 21-39 | |
| » Starters: Sam McDowell vs Steve Arlin | Fifth | 15½ out |
| Saturday, June 24 |
| » Lost to Giants (23-45), 7-4 | San Diego/Jack Murphy Stadium (11-26) | 21-40 | |
| » Starters: Don Carrithers vs Bill Greif | Fifth | 16 out |
| Sunday, June 25 |
| » Lost to Giants (24-45), 6-5 | San Diego/Jack Murphy Stadium (11-27) | 21-41 | Lost 2 |
| » Starters: Jim Barr vs Fred Norman | Sixth | 16½ out |
| Monday, June 26 |
| » Lost to Astros (39-26), 14-7 | San Diego/Jack Murphy Stadium (11-28) | 21-42 | Lost 3 |
| » Starters: Don Wilson vs Clay Kirby | Sixth | 17½ out |
| Tuesday, June 27 |
| » Lost to Astros (40-26), 6-0 | San Diego/Jack Murphy Stadium (11-29) | 21-43 | Lost 4 |
| » Starters: Dave Roberts vs Steve Arlin | Sixth | 18½ out |
| Wednesday, June 28 |
| » Lost to Braves (30-34), 4-2 | San Diego/Jack Murphy Stadium (11-30) | 21-44 | Lost 5 |
| » Starters: Ron Schueler vs Mike Corkins | Sixth | 19 out |
| » Defeated Braves (30-35), 4-2 | San Diego/Jack Murphy Stadium (12-30) | 22-44 | |
| » Starters: Jim Hardin vs Fred Norman | Sixth | 19 out |
| Thursday, June 29 |
| » Defeated Braves (30-36), 8-6 | San Diego/Jack Murphy Stadium (13-30) | 23-44 | Won 2 |
| » Starters: George Stone vs Mike Caldwell | Sixth | 18 out |
| Friday, June 30 |
| » Defeated Reds (41-27), 4-3 | San Diego/Jack Murphy Stadium (14-30) | 24-44 | Won 3 |
| » Starters: Wayne Simpson vs Clay Kirby | Sixth | 17 out |
| Saturday, July 1 |
| » Lost to Reds (42-27), 3-2 | San Diego/Jack Murphy Stadium (14-31) | 24-45 | |
| » Starters: Ed Sprague vs Steve Arlin | Sixth | 18 out |
| Sunday, July 2 |
| » Lost to Reds (43-27), 12-2 | San Diego/Jack Murphy Stadium (14-32) | 24-46 | Lost 2 |
| » Starters: Gary Nolan vs Mike Corkins | Sixth | 19 out |
| Tuesday, July 4 |
| » Lost to Mets (43-27), 2-0 | Shea Stadium (2-2) | 24-47 | Lost 3 |
| » Starters: Clay Kirby vs Tom Seaver | Sixth | 19 out |
| » Defeated Mets (43-28), 4-2 | Shea Stadium (3-2) | 25-47 | |
| » Starters: Mike Caldwell vs Gary Gentry | Sixth | 19 out |
| Thursday, July 6 |
| » Defeated Mets (43-29), 1-0 | Shea Stadium (4-2) | 26-47 | Won 2 |
| » Starters: Steve Arlin vs Jerry Koosman | Sixth | 18½ out |
| Friday, July 7 |
| » Lost to Phillies (26-47), 4-2 | Veteran's Stadium (1-2) | 26-48 | |
| » Starters: Mike Corkins vs Steve Carlton | Sixth | 18 out |
| » Defeated Phillies (26-48), 6-1 | Veteran's Stadium (2-2) | 27-48 | |
| » Starters: Clay Kirby vs Jim Nash | Sixth | 18 out |
| Saturday, July 8 |
| » Defeated Phillies (26-49), 8-5 | Veteran's Stadium (3-2) | 28-48 | Won 2 |
| » Starters: Mike Caldwell vs Bill Champion | Sixth | 18 out |
| Sunday, July 9 |
| » Defeated Phillies (26-50), 5-4 | Veteran's Stadium (4-2) | 29-48 | Won 3 |
| » Starters: Bill Greif vs Bucky Brandon | Sixth | 16½ out |
| Monday, July 10 |
| » Lost to Expos (33-43), 6-3 | Parc Jarry (2-2) | 29-49 | |
| » Starters: Steve Arlin vs Balor Moore | Sixth | 17 out |
| Tuesday, July 11 |
| » Lost to Expos (34-43), 6-5 | Parc Jarry (2-3) | 29-50 | Lost 2 |
| » Starters: Clay Kirby vs Mike Torrez | Sixth | 18 out |
| Wednesday, July 12 |
| » Defeated Expos (34-44), 6-5 | Parc Jarry (3-3) | 30-50 | |
| » Starters: Mike Caldwell vs Bill Stoneman | Sixth | 18 out |
| Friday, July 14 |
| » Lost to Mets (46-33), 3-2 | San Diego/Jack Murphy Stadium (14-33) | 30-51 | |
| » Starters: Tom Seaver vs Steve Arlin | Sixth | 19½ out |
| » Major-league debuts: Dave Schneck (Mets) |
| Saturday, July 15 |
| » Lost to Mets (47-33), 2-1 | San Diego/Jack Murphy Stadium (14-34) | 30-52 | Lost 2 |
| » Starters: Gary Gentry vs Clay Kirby | Sixth | 20½ out |
| Sunday, July 16 |
| » Defeated Mets (47-34), 7-3 | San Diego/Jack Murphy Stadium (15-34) | 31-52 | |
| » Starters: Jerry Koosman vs Mike Corkins | Sixth | 20½ out |
| Tuesday, July 18 |
| » Defeated Phillies (29-55), 5-1 | San Diego/Jack Murphy Stadium (16-34) | 32-52 | Won 2 |
| » Starters: Bill Champion vs Steve Arlin | Sixth | 20 out |
| Wednesday, July 19 |
| » Lost to Phillies (30-55), 3-2 | San Diego/Jack Murphy Stadium (16-35) | 32-53 | |
| » Starters: Steve Carlton vs Clay Kirby | Sixth | 21 out |
| Friday, July 21 |
| » Defeated Expos (37-47), 5-4 | San Diego/Jack Murphy Stadium (17-35) | 33-53 | |
| » Starters: Bill Stoneman vs Mike Caldwell | Sixth | 21 out |
| Saturday, July 22 |
| » Lost to Expos (38-47), 3-1 | San Diego/Jack Murphy Stadium (17-36) | 33-54 | |
| » Starters: Carl Morton vs Fred Norman | Sixth | 22 out |
| Sunday, July 23 |
| » Lost to Expos (39-47), 2-1 | San Diego/Jack Murphy Stadium (17-37) | 33-55 | Lost 2 |
| » Starters: Mike Torrez vs Steve Arlin | Sixth | 22½ out |
| » Lost to Expos (40-47), 9-1 | San Diego/Jack Murphy Stadium (17-38) | 33-56 | Lost 3 |
| » Starters: Balor Moore vs Clay Kirby | Sixth | 22½ out |
| Thursday, July 27 |
| » Lost to Reds (56-33), 8-2 | Riverfront Stadium (1-3) | 33-57 | Lost 4 |
| » Starters: Steve Arlin vs Jack Billingham | Sixth | 23½ out |
| Friday, July 28 |
| » Defeated Reds (56-34), 3-1 | Riverfront Stadium (2-3) | 34-57 | |
| » Starters: Clay Kirby vs Wayne Simpson | Sixth | 22½ out |
| Saturday, July 29 |
| » Defeated Reds (56-35), 4-3 | Riverfront Stadium (3-3) | 35-57 | Won 2 |
| » Starters: Mike Caldwell vs Gary Nolan | Sixth | 21½ out |
| Sunday, July 30 |
| » Defeated Astros (52-44), 10-7 | Astrodome (1-0) | 36-57 | Won 3 |
| » Starters: Fred Norman vs J.R. Richard | Sixth | 21½ out |
| » Lost to Astros (53-44), 4-3 | Astrodome (1-1) | 36-58 | |
| » Starters: Bill Greif vs Dave Roberts | Sixth | 21½ out |
| Monday, July 31 |
| » Lost to Astros (54-44), 3-2 | Astrodome (1-2) | 36-59 | Lost 2 |
| » Starters: Steve Arlin vs Larry Dierker | Sixth | 21½ out |
| Tuesday, August 1 |
| » Defeated Braves (46-51), 9-0 | Atlanta-Fulton County Stadium (1-2) | 37-59 | |
| » Starters: Clay Kirby vs Ron Schueler | Sixth | 21 out |
| » Defeated Braves (46-52), 11-7 | Atlanta-Fulton County Stadium (2-2) | 38-59 | Won 2 |
| » Starters: Ed Acosta vs Tom Kelley | Sixth | 21 out |
| Wednesday, August 2 |
| » Defeated Braves (46-53), 5-0 | Atlanta-Fulton County Stadium (3-2) | 39-59 | Won 3 |
| » Starters: Fred Norman vs Phil Niekro | Sixth | 20 out |
| Thursday, August 3 |
| » Defeated Braves (46-54), 6-5 | Atlanta-Fulton County Stadium (4-2) | 40-59 | Won 4 |
| » Starters: Bill Greif vs Ron Reed | Sixth | 19½ out |
| Friday, August 4 |
| » Defeated Dodgers (51-48), 2-0 | Dodger Stadium (2-2) | 41-59 | Won 5 |
| » Starters: Mike Caldwell vs Bill Singer | Sixth | 20 out |
| Saturday, August 5 |
| » Lost to Dodgers (52-48), 1-0 | Dodger Stadium (2-3) | 41-60 | |
| » Starters: Clay Kirby vs Claude Osteen | Sixth | 21 out |
| Sunday, August 6 |
| » Lost to Dodgers (53-48), 6-0 | Dodger Stadium (2-4) | 41-61 | Lost 2 |
| » Starters: Fred Norman vs Don Sutton | Sixth | 21 out |
| Tuesday, August 8 |
| » Lost to Giants (47-59), 15-4 | Candlestick Park (0-1) | 41-62 | Lost 3 |
| » Starters: Steve Arlin vs Frank Reberger | Sixth | 23 out |
| » Lost to Giants (48-59), 7-3 | Candlestick Park (0-2) | 41-63 | Lost 4 |
| » Starters: Bill Greif vs Steve Stone | Sixth | 23 out |
| Wednesday, August 9 |
| » Defeated Giants (48-60), 5-2 | Candlestick Park (1-2) | 42-63 | |
| » Starters: Clay Kirby vs Juan Marichal | Sixth | 23 out |
| Future Padre Dusty Allen is born in Oklahoma City, OK. |
| Friday, August 11 |
| » Lost to Dodgers (55-50), 2-1 | San Diego/Jack Murphy Stadium (17-39) | 42-64 | |
| » Starters: Don Sutton vs Mike Caldwell | Sixth | 22½ out |
| Saturday, August 12 |
| » Lost to Dodgers (56-50), 5-2 | San Diego/Jack Murphy Stadium (17-40) | 42-65 | Lost 2 |
| » Starters: Tommy John vs Steve Arlin | Sixth | 22½ out |
| Sunday, August 13 |
| » Lost to Dodgers (57-50), 5-3 | San Diego/Jack Murphy Stadium (17-41) | 42-66 | Lost 3 |
| » Starters: Bill Singer vs Clay Kirby | Sixth | 23½ out |
| Tuesday, August 15 |
| » Defeated Cardinals (52-56), 7-1 | San Diego/Jack Murphy Stadium (18-41) | 43-66 | |
| » Starters: Reggie Cleveland vs Mike Caldwell | Sixth | 24 out |
| Wednesday, August 16 |
| » Lost to Cardinals (53-56), 6-4 | San Diego/Jack Murphy Stadium (18-42) | 43-67 | |
| » Starters: Bob Gibson vs Steve Arlin | Sixth | 25 out |
| Thursday, August 17 |
| » Defeated Cardinals (53-57), 3-2 | San Diego/Jack Murphy Stadium (19-42) | 44-67 | |
| » Starters: Rick Wise vs Clay Kirby | Sixth | 24 out |
| Future Padre Roberto Ramirez is born in El Laurel, Mexico. |
| Friday, August 18 |
| » Lost to Pirates (70-42), 4-2 | San Diego/Jack Murphy Stadium (19-43) | 44-68 | |
| » Starters: Steve Blass vs Bill Greif | Sixth | 25 out |
| Sunday, August 20 |
| » Lost to Pirates (71-42), 9-3 | San Diego/Jack Murphy Stadium (19-44) | 44-69 | Lost 2 |
| » Starters: Dock Ellis vs Mike Caldwell | Fifth | 27 out |
| » Lost to Pirates (72-42), 5-2 | San Diego/Jack Murphy Stadium (19-45) | 44-70 | Lost 3 |
| » Starters: Bruce Kison vs Fred Norman | Fifth | 27 out |
| Monday, August 21 |
| » Defeated Cubs (61-56), 6-5 | San Diego/Jack Murphy Stadium (20-45) | 45-70 | |
| » Starters: Bill Hands vs Clay Kirby | Sixth | 27 out |
| Tuesday, August 22 |
| » Lost to Cubs (62-56), 4-3 | San Diego/Jack Murphy Stadium (20-46) | 45-71 | |
| » Starters: Fergie Jenkins vs Steve Arlin | Sixth | 28 out |
| Wednesday, August 23 |
| » Lost to Cubs (63-56), 7-5 | San Diego/Jack Murphy Stadium (20-47) | 45-72 | Lost 2 |
| » Starters: Milt Pappas vs Bill Greif | Sixth | 28 out |
| Friday, August 25 |
| » Lost to Cardinals (57-60), 7-4 | Busch Stadium II (0-3) | 45-73 | Lost 3 |
| » Starters: Mike Caldwell vs Reggie Cleveland | Sixth | 29 out |
| » Defeated Cardinals (57-61), 8-7 | Busch Stadium II (1-3) | 46-73 | |
| » Starters: Fred Norman vs Al Santorini | Sixth | 29 out |
| Saturday, August 26 |
| » Lost to Cardinals (58-61), 9-3 | Busch Stadium II (1-4) | 46-74 | |
| » Starters: Steve Arlin vs Bob Gibson | Sixth | 29 out |
| Sunday, August 27 |
| » Lost to Cardinals (59-61), 9-2 | Busch Stadium II (1-5) | 46-75 | Lost 2 |
| » Starters: Clay Kirby vs Rick Wise | Sixth | 30 out |
| Monday, August 28 |
| » Lost to Pirates (75-46), 5-3 | Three Rivers Stadium (2-2) | 46-76 | Lost 3 |
| » Starters: Mike Caldwell vs Bob Moose | Sixth | 31 out |
| Future Padre Jay Witasick is born in Baltimore, MD. |
| Tuesday, August 29 |
| » Lost to Pirates (76-46), 5-3 | Three Rivers Stadium (2-3) | 46-77 | Lost 4 |
| » Starters: Mike Corkins vs Steve Blass | Sixth | 31 out |
| Wednesday, August 30 |
| » Lost to Pirates (77-46), 11-0 | Three Rivers Stadium (2-4) | 46-78 | Lost 5 |
| » Starters: Steve Arlin vs Bruce Kison | Sixth | 32 out |
| Friday, September 1 |
| » Lost to Cubs (68-58), 14-3 | Wrigley Field (1-3) | 46-79 | Lost 6 |
| » Starters: Bill Greif vs Bill Hands | Sixth | 33 out |
| » Major-league debuts: Al Montreuil (Cubs) |
| Saturday, September 2 |
| » Lost to Cubs (69-58), 8-0 | Wrigley Field (1-4) | 46-80 | Lost 7 |
| » Starters: Mike Caldwell vs Milt Pappas | Sixth | 33 out |
| Sunday, September 3 |
| » Defeated Cubs (69-59), 3-0 | Wrigley Field (2-4) | 47-80 | |
| » Starters: Fred Norman vs Burt Hooton | Sixth | 33 out |
| Monday, September 4 |
| » Defeated Giants (56-74), 1-0 | San Diego/Jack Murphy Stadium (21-47) | 48-80 | Won 2 |
| » Starters: Jim Willoughby vs Mike Corkins | Sixth | 32½ out |
| Tuesday, September 5 |
| » Lost to Giants (57-74), 4-3 | San Diego/Jack Murphy Stadium (21-48) | 48-81 | |
| » Starters: Frank Reberger vs Steve Arlin | Sixth | 32½ out |
| » Major-league debuts: Gary Thomasson (Giants) |
| Wednesday, September 6 |
| » Lost to Giants (58-74), 6-0 | San Diego/Jack Murphy Stadium (21-49) | 48-82 | Lost 2 |
| » Starters: Ron Bryant vs Bill Greif | Sixth | 33½ out |
| » Major-league debuts: Gary Matthews (Giants) |
| Thursday, September 7 |
| » Defeated Reds (82-50), 2-0 | San Diego/Jack Murphy Stadium (22-49) | 49-82 | |
| » Starters: Gary Nolan vs Mike Caldwell | Sixth | 31½ out |
| » Defeated Reds (82-51), 5-1 | San Diego/Jack Murphy Stadium (23-49) | 50-82 | Won 2 |
| » Starters: Jack Billingham vs Fred Norman | Sixth | 31½ out |
| Friday, September 8 |
| » Major-league debuts: Chuck Goggin (Pirates) |
| Sunday, September 10 |
| » Defeated Braves (63-73), 1-0 | San Diego/Jack Murphy Stadium (24-49) | 51-82 | Won 3 |
| » Starters: Ron Reed vs Mike Corkins | Sixth | 31 out |
| » Lost to Braves (64-73), 4-1 | San Diego/Jack Murphy Stadium (24-50) | 51-83 | |
| » Starters: Phil Niekro vs Steve Arlin | Sixth | 31 out |
| » Major-league debuts: Johnny Grubb and Dave Hilton (Padres) |
| Wednesday, September 13 |
| » Lost to Astros (77-60), 6-5 | Astrodome (1-3) | 51-84 | Lost 2 |
| » Starters: Mike Caldwell vs Larry Dierker | Sixth | 32½ out |
| » Major-league debuts: Cliff Johnson (Astros) |
| Thursday, September 14 |
| » Lost to Astros (78-60), 10-6 | Astrodome (1-4) | 51-85 | Lost 3 |
| » Starters: Steve Arlin vs Jerry Reuss | Sixth | 33 out |
| Friday, September 15 |
| » Defeated Reds (85-54), 1-0 | Riverfront Stadium (4-3) | 52-85 | |
| » Starters: Fred Norman vs Don Gullett | Sixth | 32 out |
| Saturday, September 16 |
| » Lost to Reds (86-54), 6-3 | Riverfront Stadium (4-4) | 52-86 | |
| » Starters: Mike Corkins vs Ross Grimsley | Sixth | 33 out |
| Future Padre Brian Tollberg is born in Tampa, FL. |
| Sunday, September 17 |
| » Defeated Reds (86-55), 10-7 | Riverfront Stadium (5-4) | 53-86 | |
| » Starters: Mike Caldwell vs Wayne Simpson | Sixth | 32 out |
| Monday, September 18 |
| » Lost to Dodgers (76-66), 3-2 | San Diego/Jack Murphy Stadium (24-51) | 53-87 | |
| » Starters: Tommy John vs Steve Arlin | Sixth | 33 out |
| Tuesday, September 19 |
| » Defeated Dodgers (76-67), 5-2 | San Diego/Jack Murphy Stadium (25-51) | 54-87 | |
| » Starters: Bill Singer vs Clay Kirby | Sixth | 33 out |
| Wednesday, September 20 |
| » Lost to Dodgers (77-67), 5-3 | San Diego/Jack Murphy Stadium (25-52) | 54-88 | |
| » Starters: Claude Osteen vs Fred Norman | Sixth | 34 out |
| Thursday, September 21 |
| » Major-league debuts: Joe Nolan (Mets) |
| Friday, September 22 |
| » Lost to Braves (68-77), 2-0 | Atlanta-Fulton County Stadium (4-3) | 54-89 | Lost 2 |
| » Starters: Mike Caldwell vs Phil Niekro | Sixth | 35 out |
| Saturday, September 23 |
| » Defeated Braves (68-78), 4-1 | Atlanta-Fulton County Stadium (5-3) | 55-89 | |
| » Starters: Steve Arlin vs Jimmy Freeman | Sixth | 34 out |
| Sunday, September 24 |
| » Defeated Braves (68-79), 2-1 | Atlanta-Fulton County Stadium (6-3) | 56-89 | Won 2 |
| » Starters: Clay Kirby vs Mike McQueen | Sixth | 34 out |
| Monday, September 25 |
| » Defeated Dodgers (80-68), 5-3 | Dodger Stadium (3-4) | 57-89 | Won 3 |
| » Starters: Fred Norman vs Claude Osteen | Sixth | 33½ out |
| Tuesday, September 26 |
| » Lost to Dodgers (81-68), 7-3 | Dodger Stadium (3-5) | 57-90 | |
| » Starters: Mike Caldwell vs Mike Strahler | Sixth | 33½ out |
| » Major-league debuts: Ralph Garcia (Padres) |
| Wednesday, September 27 |
| » Lost to Dodgers (82-68), 2-0 | Dodger Stadium (3-6) | 57-91 | Lost 2 |
| » Starters: Steve Arlin vs Don Sutton | Sixth | 33½ out |
| Friday, September 29 |
| » Lost to Astros (83-66), 5-2 | San Diego/Jack Murphy Stadium (25-53) | 57-92 | Lost 3 |
| » Starters: Ken Forsch vs Clay Kirby | Sixth | 34½ out |
| Saturday, September 30 |
| » Lost to Astros (84-66), 6-5 | San Diego/Jack Murphy Stadium (25-54) | 57-93 | Lost 4 |
| » Starters: Jerry Reuss vs Fred Norman | Sixth | 34½ out |
| Sunday, October 1 |
| » Defeated Astros (84-67), 3-1 | San Diego/Jack Murphy Stadium (26-54) | 58-93 | |
| » Starters: Don Wilson vs Steve Arlin | Sixth | 34½ out |
| Tuesday, October 3 |
| » Lost to Giants (68-86), 7-4 | Candlestick Park (1-3) | 58-94 | |
| » Starters: Mike Caldwell vs Jim Willoughby | Sixth | 35½ out |
| Wednesday, October 4 |
| » Lost to Giants (69-86), 6-4 | Candlestick Park (1-4) | 58-95 | Lost 2 |
| » Starters: Fred Norman vs Ron Bryant | Sixth | 36½ out |
| Future Padre Adam Riggs is born in Steubenville, OH. |
| Thursday, October 19 |
| Future Padre Marc Newfield is born in Sacramento, CA. |
| Friday, November 10 |
| Future Padre Greg LaRocca is born in Oswego, NY. |
| Thursday, December 21 |
| Future Padre Dustin Hermanson is born in Springfield, OH. |
Game information provided by Retrosheet (www.retrosheet.org) |