| Sunday, February 20 |
| Future Indian Shane Spencer is born in Key West, FL. |
| Saturday, March 4 |
| Future Indian Bruce Aven is born in Orange, TX. Former Indian Watty Clark dies in Clearwater, FL at the age of 70 |
| Sunday, March 12 |
| Former Indian Dutch Levsen dies in St.Louis Park, MN at the age of 74. |
| Friday, March 24 |
| Future Indian Steve Karsay is born in Flushing, NY. |
| Saturday, April 15 |
| » Lost to Brewers (1-0), 5-1 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Bill Parsons vs Gaylord Perry | Third | 1 out |
| » Major-league debuts: Buddy Bell (Indians) |
| Monday, April 17 |
| » Defeated Red Sox (0-2), 4-0 | Fenway Park (1-0) | 1-1 | |
| » Starters: Milt Wilcox vs Ray Culp | Third | 1 out |
| Tuesday, April 18 |
| » Lost to Red Sox (1-2), 4-2 | Fenway Park (1-1) | 1-2 | |
| » Starters: Dick Tidrow vs Sonny Siebert | Fourth | 1½ out |
| » Major-league debuts: Jack Brohamer and Dick Tidrow (Indians) |
| Wednesday, April 19 |
| » Defeated Red Sox (1-3), 3-1 | Fenway Park (2-1) | 2-2 | |
| » Starters: Gaylord Perry vs Marty Pattin | Third | 1 out |
| Friday, April 21 |
| » Lost to Orioles (5-1), 6-0 | Cleveland Stadium (0-2) | 2-3 | |
| » Starters: Dave McNally vs Milt Wilcox | Third | 2½ out |
| Saturday, April 22 |
| » Defeated Orioles (5-2), 9-2 | Cleveland Stadium (1-2) | 3-3 | |
| » Starters: Jim Palmer vs Dick Tidrow | Third | 1½ out |
| Sunday, April 23 |
| » Defeated Orioles (5-3), 2-1 | Cleveland Stadium (2-2) | 4-3 | Won 2 |
| » Starters: Mike Cuellar vs Gaylord Perry | Second | ½ out |
| Tuesday, April 25 |
| » Lost to White Sox (6-3), 6-0 | Comiskey Park I (0-1) | 4-4 | |
| » Starters: Milt Wilcox vs Wilbur Wood | Third | ½ out |
| Wednesday, April 26 |
| » Lost to White Sox (7-3), 7-5 | Comiskey Park I (0-2) | 4-5 | Lost 2 |
| » Starters: Dick Tidrow vs Tom Bradley | Third | 1½ out |
| Future Indian Brian Anderson is born in Portsmouth, VA. |
| Friday, April 28 |
| » Lost to Royals (6-6), 4-0 | Municipal Stadium (0-1) | 4-6 | Lost 3 |
| » Starters: Gaylord Perry vs Paul Splittorff | Third | 2½ out |
| Saturday, April 29 |
| » Defeated Royals (6-7), 3-1 | Municipal Stadium (1-1) | 5-6 | |
| » Starters: Milt Wilcox vs Monty Montgomery | Third | 2½ out |
| Sunday, April 30 |
| » Defeated Royals (6-8), 5-3 | Municipal Stadium (2-1) | 6-6 | Won 2 |
| » Starters: Dick Tidrow vs Dick Drago | Third | 1½ out |
| Tuesday, May 2 |
| » Defeated Rangers (7-7), 4-2 | Arlington Stadium (1-0) | 7-6 | Won 3 |
| » Starters: Gaylord Perry vs Dick Bosman | Third | ½ out |
| Wednesday, May 3 |
| » Defeated Rangers (7-8), 2-1 | Arlington Stadium (2-0) | 8-6 | Won 4 |
| » Starters: Milt Wilcox vs Pete Broberg | Second | ½ out |
| Friday, May 5 |
| » Lost to White Sox (9-6), 2-1 | Cleveland Stadium (2-3) | 8-7 | |
| » Starters: Wilbur Wood vs Dick Tidrow | Third | 1 out |
| Saturday, May 6 |
| » Defeated White Sox (9-7), 12-0 | Cleveland Stadium (3-3) | 9-7 | |
| » Starters: Tom Bradley vs Gaylord Perry | Second | ½ out |
| Sunday, May 7 |
| » Defeated White Sox (9-8), 3-0 | Cleveland Stadium (4-3) | 10-7 | Won 2 |
| » Starters: Stan Bahnsen vs Milt Wilcox | Second | ½ out |
| Tuesday, May 9 |
| » Defeated Royals (8-12), 2-1 | Cleveland Stadium (5-3) | 11-7 | Won 3 |
| » Starters: Paul Splittorff vs Dick Tidrow | Second | ½ out |
| Wednesday, May 10 |
| » Defeated Royals (8-13), 7-2 | Cleveland Stadium (6-3) | 12-7 | Won 4 |
| » Starters: Mike Hedlund vs Gaylord Perry | First | -- |
| Thursday, May 11 |
| Future Indian Cam Cairncross is born in Queensland, Australia. |
| Friday, May 12 |
| » Lost to Rangers (10-11), 3-1 | Cleveland Stadium (6-4) | 12-8 | |
| » Starters: Dick Bosman vs Milt Wilcox | Second | 1 out |
| Saturday, May 13 |
| » Defeated Rangers (10-12), 7-3 | Cleveland Stadium (7-4) | 13-8 | |
| » Starters: Rich Hand vs Dick Tidrow | Second | 1 out |
| Sunday, May 14 |
| » Defeated Rangers (10-13), 4-3 | Cleveland Stadium (8-4) | 14-8 | Won 2 |
| » Starters: Jim Shellenback vs Gaylord Perry | First | -- |
| Tuesday, May 16 |
| » Lost to Yankees (9-14), 3-1 | Cleveland Stadium (8-5) | 14-9 | |
| » Starters: Mike Kekich vs Steve Hargan | First | -- |
| Wednesday, May 17 |
| » Defeated Yankees (9-15), 2-1 | Cleveland Stadium (9-5) | 15-9 | |
| » Starters: Steve Kline vs Dick Tidrow | First | -- |
| Friday, May 19 |
| » Defeated Tigers (15-11), 2-1 | Tiger Stadium (1-0) | 16-9 | Won 2 |
| » Starters: Gaylord Perry vs Les Cain | First | -- |
| Saturday, May 20 |
| » Defeated Tigers (15-12), 2-1 | Tiger Stadium (2-0) | 17-9 | Won 3 |
| » Starters: Vince Colbert vs Tom Timmermann | First | -- |
| Sunday, May 21 |
| » Lost to Tigers (16-12), 5-0 | Tiger Stadium (2-1) | 17-10 | |
| » Starters: Dick Tidrow vs Mickey Lolich | First | -- |
| Tuesday, May 23 |
| » Defeated Yankees (12-16), 3-0 | Yankee Stadium (1-0) | 18-10 | |
| » Starters: Gaylord Perry vs Mel Stottlemyre | First | -- |
| Wednesday, May 24 |
| » Lost to Yankees (13-16), 4-2 | Yankee Stadium (1-1) | 18-11 | |
| » Starters: Vince Colbert vs Rich Hinton | First | -- |
| Thursday, May 25 |
| » Lost to Yankees (14-16), 2-0 | Yankee Stadium (1-2) | 18-12 | Lost 2 |
| » Starters: Dick Tidrow vs Fritz Peterson | First | -- |
| Friday, May 26 |
| » Lost to Orioles (17-15), 2-0 | Memorial Stadium (0-1) | 18-13 | Lost 3 |
| » Starters: Milt Wilcox vs Mike Cuellar | First | -- |
| Saturday, May 27 |
| » Lost to Orioles (18-15), 4-2 | Memorial Stadium (0-2) | 18-14 | Lost 4 |
| » Starters: Gaylord Perry vs Dave McNally | Second | ½ out |
| Sunday, May 28 |
| » Lost to Orioles (19-15), 5-1 | Memorial Stadium (0-3) | 18-15 | Lost 5 |
| » Starters: Vince Colbert vs Jim Palmer | Third | 1½ out |
| Monday, May 29 |
| » Lost to Orioles (20-15), 6-1 | Memorial Stadium (0-4) | 18-16 | Lost 6 |
| » Starters: Dick Tidrow vs Pat Dobson | Third | 1½ out |
| Former Indian Moe Berg dies in Belleville, NJ at the age of 71. |
| Tuesday, May 30 |
| Future Indian Manny Ramirez is born in Santo Domingo, D.R. |
| Wednesday, May 31 |
| » Lost to Tigers (21-16), 5-4 | Cleveland Stadium (9-6) | 18-17 | Lost 7 |
| » Starters: Tom Timmermann vs Milt Wilcox | Third | 2 out |
| Future Indian Dave Roberts is born in Okinawa, Japan. |
| Thursday, June 1 |
| » Defeated Tigers (21-17), 1-0 | Cleveland Stadium (10-6) | 19-17 | |
| » Starters: Joe Coleman vs Gaylord Perry | Third | 1 out |
| Friday, June 2 |
| » Lost to Angels (19-23), 4-3 | Cleveland Stadium (10-7) | 19-18 | |
| » Starters: Clyde Wright vs Vince Colbert | Third | 2 out |
| Saturday, June 3 |
| » Lost to Angels (20-23), 8-4 | Cleveland Stadium (10-8) | 19-19 | Lost 2 |
| » Starters: Nolan Ryan vs Dick Tidrow | Third | 3 out |
| Sunday, June 4 |
| » Defeated Angels (20-24), 6-4 | Cleveland Stadium (11-8) | 20-19 | |
| » Starters: Rickey Clark vs Milt Wilcox | Second | 3 out |
| Monday, June 5 |
| » Lost to Athletics (29-13), 3-2 | Cleveland Stadium (11-9) | 20-20 | |
| » Starters: Blue Moon Odom vs Gaylord Perry | Second | 3½ out |
| Tuesday, June 6 |
| » Lost to Athletics (30-13), 7-2 | Cleveland Stadium (11-10) | 20-21 | Lost 2 |
| » Starters: Vida Blue vs Vince Colbert | Second | 4 out |
| Wednesday, June 7 |
| » Lost to Athletics (31-13), 10-4 | Cleveland Stadium (11-11) | 20-22 | Lost 3 |
| » Starters: Ken Holtzman vs Dick Tidrow | Third | 4 out |
| Friday, June 9 |
| » Defeated Twins (25-18), 7-1 | Cleveland Stadium (12-11) | 21-22 | |
| » Starters: Bert Blyleven vs Gaylord Perry | Third | 3 out |
| Saturday, June 10 |
| » Defeated Twins (25-19), 4-1 | Cleveland Stadium (13-11) | 22-22 | Won 2 |
| » Starters: Dick Woodson vs Milt Wilcox | Third | 2 out |
| Sunday, June 11 |
| » Lost to Twins (26-19), 5-3 | Cleveland Stadium (13-12) | 22-23 | |
| » Starters: Jim Kaat vs Vince Colbert | Third | 3 out |
| Tuesday, June 13 |
| » Lost to Angels (24-27), 3-2 | Anaheim Stadium (0-1) | 22-24 | Lost 2 |
| » Starters: Gaylord Perry vs Rudy May | Second | 3½ out |
| Wednesday, June 14 |
| » Lost to Angels (25-27), 4-3 | Anaheim Stadium (0-2) | 22-25 | Lost 3 |
| » Starters: Milt Wilcox vs Nolan Ryan | Second | 4½ out |
| Thursday, June 15 |
| » Defeated Angels (25-28), 1-0 | Anaheim Stadium (1-2) | 23-25 | |
| » Starters: Vince Colbert vs Clyde Wright | Second | 4 out |
| Friday, June 16 |
| » Lost to Athletics (34-17), 5-0 | Oakland-Alameda County Stadium (0-1) | 23-26 | |
| » Starters: Dick Tidrow vs Ken Holtzman | Second | 5 out |
| Saturday, June 17 |
| » Lost to Athletics (35-17), 3-2 | Oakland-Alameda County Stadium (0-2) | 23-27 | Lost 2 |
| » Starters: Gaylord Perry vs Dave Hamilton | Second | 6 out |
| Sunday, June 18 |
| » Lost to Athletics (36-17), 9-0 | Oakland-Alameda County Stadium (0-3) | 23-28 | Lost 3 |
| » Starters: Milt Wilcox vs Vida Blue | Fourth | 7 out |
| Tuesday, June 20 |
| » Lost to Twins (29-23), 7-3 | Metropolitan Stadium (0-1) | 23-29 | Lost 4 |
| » Starters: Vince Colbert vs Jim Kaat | Fourth | 7 out |
| » Lost to Twins (30-23), 3-1 | Metropolitan Stadium (0-2) | 23-30 | Lost 5 |
| » Starters: Ray Lamb vs Dick Woodson | Fourth | 7 out |
| Wednesday, June 21 |
| » Defeated Twins (30-24), 4-2 | Metropolitan Stadium (1-2) | 24-30 | |
| » Starters: Gaylord Perry vs Bert Blyleven | Fifth | 7 out |
| Friday, June 23 |
| » Lost to Yankees (26-29), 4-1 | Cleveland Stadium (13-13) | 24-31 | |
| » Starters: Fritz Peterson vs Milt Wilcox | Fifth | 7½ out |
| Sunday, June 25 |
| » Defeated Yankees (26-30), 4-3 | Cleveland Stadium (14-13) | 25-31 | |
| » Starters: Mel Stottlemyre vs Gaylord Perry | Second | 6 out |
| » Defeated Yankees (26-31), 5-1 | Cleveland Stadium (15-13) | 26-31 | Won 2 |
| » Starters: Steve Kline vs Mike Kilkenny | Second | 6 out |
| Monday, June 26 |
| » Defeated Red Sox (25-33), 7-3 | Cleveland Stadium (16-13) | 27-31 | Won 3 |
| » Starters: Ray Culp vs Ray Lamb | Third | 6 out |
| Tuesday, June 27 |
| » Lost to Red Sox (26-33), 8-2 | Cleveland Stadium (16-14) | 27-32 | |
| » Starters: John Curtis vs Vince Colbert | Third | 7 out |
| Wednesday, June 28 |
| » Lost to Brewers (24-37), 4-2 | County Stadium (0-1) | 27-33 | Lost 2 |
| » Starters: Dick Tidrow vs Gary Ryerson | Fourth | 7½ out |
| » Lost to Brewers (25-37), 5-2 | County Stadium (0-2) | 27-34 | Lost 3 |
| » Starters: Milt Wilcox vs Jim Lonborg | Fourth | 7½ out |
| » Major-league debuts: Gary Ryerson (Brewers) |
| Thursday, June 29 |
| » Lost to Brewers (26-37), 3-1 | County Stadium (0-3) | 27-35 | Lost 4 |
| » Starters: Ray Lamb vs Earl Stephenson | Fourth | 8½ out |
| Friday, June 30 |
| » Lost to Yankees (28-34), 1-0 | Yankee Stadium (1-3) | 27-36 | Lost 5 |
| » Starters: Gaylord Perry vs Steve Kline | Fifth | 8½ out |
| Saturday, July 1 |
| » Lost to Yankees (29-34), 5-1 | Yankee Stadium (1-4) | 27-37 | Lost 6 |
| » Starters: Mike Kilkenny vs Mike Kekich | Fifth | 9½ out |
| Sunday, July 2 |
| » Lost to Yankees (30-34), 6-1 | Yankee Stadium (1-5) | 27-38 | Lost 7 |
| » Starters: Ray Lamb vs Fritz Peterson | Fifth | 10 out |
| » Lost to Yankees (31-34), 5-2 | Yankee Stadium (1-6) | 27-39 | Lost 8 |
| » Starters: Milt Wilcox vs Rob Gardner | Fifth | 10 out |
| Tuesday, July 4 |
| » Defeated Rangers (29-41), 2-0 | Cleveland Stadium (17-14) | 28-39 | |
| » Starters: Rich Hand vs Mike Kilkenny | Fifth | 9½ out |
| Thursday, July 6 |
| » Defeated Rangers (29-42), 4-3 | Cleveland Stadium (18-14) | 29-39 | Won 2 |
| » Starters: Bill Gogolewski vs Gaylord Perry | Fifth | 9½ out |
| » Defeated Rangers (29-43), 6-5 | Cleveland Stadium (19-14) | 30-39 | Won 3 |
| » Starters: Pete Broberg vs Ray Lamb | Fifth | 9½ out |
| Friday, July 7 |
| » Lost to Royals (36-36), 6-3 | Cleveland Stadium (19-15) | 30-40 | |
| » Starters: Dick Drago vs Milt Wilcox | Fifth | 9½ out |
| Saturday, July 8 |
| » Defeated Royals (36-37), 2-1 | Cleveland Stadium (20-15) | 31-40 | |
| » Starters: Roger Nelson vs Mike Kilkenny | Fifth | 8 out |
| Sunday, July 9 |
| » Lost to Royals (37-37), 6-4 | Cleveland Stadium (20-16) | 31-41 | |
| » Starters: Paul Splittorff vs Vince Colbert | Fourth | 8½ out |
| » Lost to Royals (38-37), 8-5 | Cleveland Stadium (20-17) | 31-42 | Lost 2 |
| » Starters: Mike Hedlund vs Ed Farmer | Fourth | 8½ out |
| Monday, July 10 |
| » Defeated White Sox (43-34), 2-1 | Cleveland Stadium (21-17) | 32-42 | |
| » Starters: Dave Lemonds vs Gaylord Perry | Fifth | 8½ out |
| Tuesday, July 11 |
| » Lost to White Sox (44-34), 4-3 | Cleveland Stadium (21-18) | 32-43 | |
| » Starters: Stan Bahnsen vs Dick Tidrow | Fifth | 9½ out |
| Wednesday, July 12 |
| » Lost to White Sox (45-34), 5-4 | Cleveland Stadium (21-19) | 32-44 | Lost 2 |
| » Starters: Wilbur Wood vs Mike Kilkenny | Fifth | 10½ out |
| Thursday, July 13 |
| » Lost to Rangers (34-46), 5-0 | Arlington Stadium (2-1) | 32-45 | Lost 3 |
| » Starters: Milt Wilcox vs Rich Hand | Fourth | 11½ out |
| Friday, July 14 |
| » Defeated Rangers (34-47), 2-0 | Arlington Stadium (3-1) | 33-45 | |
| » Starters: Gaylord Perry vs Mike Paul | Fifth | 10½ out |
| Saturday, July 15 |
| » Defeated Rangers (34-48), 7-0 | Arlington Stadium (4-1) | 34-45 | Won 2 |
| » Starters: Dick Tidrow vs Casey Cox | Fifth | 10½ out |
| Sunday, July 16 |
| » Lost to Rangers (35-48), 3-2 | Arlington Stadium (4-2) | 34-46 | |
| » Starters: Mike Kilkenny vs Pete Broberg | Fifth | 11½ out |
| Tuesday, July 18 |
| » Lost to Royals (42-41), 6-5 | Municipal Stadium (2-2) | 34-47 | Lost 2 |
| » Starters: Milt Wilcox vs Paul Splittorff | Fifth | 13½ out |
| » Lost to Royals (43-41), 11-8 | Municipal Stadium (2-3) | 34-48 | Lost 3 |
| » Starters: Vince Colbert vs Bruce DalCanton | Fifth | 13½ out |
| Wednesday, July 19 |
| » Defeated Royals (43-42), 6-1 | Municipal Stadium (3-3) | 35-48 | |
| » Starters: Gaylord Perry vs Dick Drago | Fifth | 12½ out |
| Friday, July 21 |
| » Defeated White Sox (46-41), 8-2 | Comiskey Park I (1-2) | 36-48 | Won 2 |
| » Starters: Dick Tidrow vs Tom Bradley | Fifth | 13 out |
| Saturday, July 22 |
| » Lost to White Sox (47-41), 5-3 | Comiskey Park I (1-3) | 36-49 | |
| » Starters: Phil Hennigan vs Stan Bahnsen | Fifth | 14 out |
| Sunday, July 23 |
| » Lost to White Sox (48-41), 2-1 | Comiskey Park I (1-4) | 36-50 | Lost 2 |
| » Starters: Gaylord Perry vs Wilbur Wood | Fifth | 14½ out |
| » Lost to White Sox (49-41), 4-3 | Comiskey Park I (1-5) | 36-51 | Lost 3 |
| » Starters: Steve Dunning vs Dave Lemonds | Fifth | 14½ out |
| Thursday, July 27 |
| » Defeated Orioles (50-39), 4-3 | Memorial Stadium (1-4) | 37-51 | |
| » Starters: Dick Tidrow vs Pat Dobson | Fifth | 15 out |
| Friday, July 28 |
| » Defeated Orioles (50-40), 4-1 | Memorial Stadium (2-4) | 38-51 | Won 2 |
| » Starters: Gaylord Perry vs Dave McNally | Fifth | 14 out |
| Saturday, July 29 |
| » Lost to Orioles (51-40), 4-3 | Memorial Stadium (2-5) | 38-52 | |
| » Starters: Steve Dunning vs Jim Palmer | Fifth | 14 out |
| Sunday, July 30 |
| » Defeated Brewers (37-55), 3-2 | Cleveland Stadium (22-19) | 39-52 | |
| » Starters: Earl Stephenson vs Milt Wilcox | Fifth | 13 out |
| » Defeated Brewers (37-56), 6-1 | Cleveland Stadium (23-19) | 40-52 | Won 2 |
| » Starters: Archie Reynolds vs Tom Hilgendorf | Fifth | 13 out |
| Monday, July 31 |
| » Defeated Brewers (37-57), 3-2 | Cleveland Stadium (24-19) | 41-52 | Won 3 |
| » Starters: Bill Parsons vs Ray Lamb | Fifth | 12½ out |
| » Defeated Brewers (37-58), 1-0 | Cleveland Stadium (25-19) | 42-52 | Won 4 |
| » Starters: Gary Ryerson vs Dick Tidrow | Fifth | 12½ out |
| Former Indian Rollie Hemsley dies in Washington, DC at the age of 66. |
| Tuesday, August 1 |
| » Defeated Orioles (52-43), 2-0 | Cleveland Stadium (26-19) | 43-52 | Won 5 |
| » Starters: Dave McNally vs Gaylord Perry | Fifth | 11½ out |
| Wednesday, August 2 |
| » Lost to Orioles (53-43), 7-0 | Cleveland Stadium (26-20) | 43-53 | |
| » Starters: Jim Palmer vs Steve Dunning | Fifth | 11 out |
| » Defeated Orioles (53-44), 6-3 | Cleveland Stadium (27-20) | 44-53 | |
| » Starters: Roric Harrison vs Milt Wilcox | Fifth | 11 out |
| Thursday, August 3 |
| » Defeated Orioles (53-45), 4-3 | Cleveland Stadium (28-20) | 45-53 | Won 2 |
| » Starters: Mike Cuellar vs Tom Hilgendorf | Fifth | 10 out |
| Friday, August 4 |
| » Defeated Tigers (55-44), 1-0 | Cleveland Stadium (29-20) | 46-53 | Won 3 |
| » Starters: Mickey Lolich vs Dick Tidrow | Fifth | 9 out |
| Saturday, August 5 |
| » Lost to Tigers (56-44), 4-3 | Cleveland Stadium (29-21) | 46-54 | |
| » Starters: Bill Slayback vs Gaylord Perry | Fifth | 10 out |
| Sunday, August 6 |
| » Defeated Tigers (56-45), 2-1 | Cleveland Stadium (30-21) | 47-54 | |
| » Starters: Joe Coleman vs Steve Dunning | Fifth | 10 out |
| » Lost to Tigers (57-45), 6-5 | Cleveland Stadium (30-22) | 47-55 | |
| » Starters: Joe Niekro vs Mike Kilkenny | Fifth | 10 out |
| Monday, August 7 |
| » Defeated Red Sox (51-50), 6-2 | Fenway Park (3-1) | 48-55 | |
| » Starters: Tom Hilgendorf vs Lynn McGlothen | Fifth | 9½ out |
| Tuesday, August 8 |
| » Lost to Red Sox (52-50), 4-1 | Fenway Park (3-2) | 48-56 | |
| » Starters: Dick Tidrow vs Marty Pattin | Fifth | 9½ out |
| Wednesday, August 9 |
| » Lost to Red Sox (53-50), 5-2 | Fenway Park (3-3) | 48-57 | Lost 2 |
| » Starters: Gaylord Perry vs Sonny Siebert | Fifth | 10 out |
| Friday, August 11 |
| » Defeated Tigers (58-49), 5-1 | Tiger Stadium (3-1) | 49-57 | |
| » Starters: Steve Dunning vs John Hiller | Fifth | 9 out |
| Future Indian Andrew Lorraine is born in Los Angeles, CA. |
| Saturday, August 12 |
| » Defeated Tigers (58-50), 6-1 | Tiger Stadium (4-1) | 50-57 | Won 2 |
| » Starters: Dick Tidrow vs Mickey Lolich | Fifth | 8½ out |
| Sunday, August 13 |
| » Lost to Tigers (59-50), 3-2 | Tiger Stadium (4-2) | 50-58 | |
| » Starters: Gaylord Perry vs Woodie Fryman | Fifth | 9 out |
| » Defeated Tigers (59-51), 9-2 | Tiger Stadium (5-2) | 51-58 | |
| » Starters: Tom Hilgendorf vs Tom Timmermann | Fifth | 9 out |
| Tuesday, August 15 |
| » Defeated Angels (49-61), 4-3 | Cleveland Stadium (31-22) | 52-58 | Won 2 |
| » Starters: Rudy May vs Steve Dunning | Fifth | 8 out |
| » Major-league debuts: Chris Coletta (Angels) |
| Wednesday, August 16 |
| » Lost to Angels (50-61), 2-1 | Cleveland Stadium (31-23) | 52-59 | |
| » Starters: Clyde Wright vs Dick Tidrow | Fifth | 8 out |
| Thursday, August 17 |
| » Lost to Angels (51-61), 4-2 | Cleveland Stadium (31-24) | 52-60 | Lost 2 |
| » Starters: Andy Messersmith vs Tom Hilgendorf | Fifth | 8 out |
| Friday, August 18 |
| » Lost to Athletics (67-46), 8-0 | Cleveland Stadium (31-25) | 52-61 | Lost 3 |
| » Starters: Blue Moon Odom vs Gaylord Perry | Fifth | 8½ out |
| Saturday, August 19 |
| » Defeated Athletics (67-47), 5-4 | Cleveland Stadium (32-25) | 53-61 | |
| » Starters: Vida Blue vs Steve Dunning | Fifth | 8½ out |
| Sunday, August 20 |
| » Defeated Athletics (67-48), 3-1 | Cleveland Stadium (33-25) | 54-61 | Won 2 |
| » Starters: Ken Holtzman vs Dick Tidrow | Fifth | 8½ out |
| Monday, August 21 |
| » Defeated Twins (60-53), 10-3 | Cleveland Stadium (34-25) | 55-61 | Won 3 |
| » Starters: Jim Perry vs Milt Wilcox | Fifth | 7½ out |
| Tuesday, August 22 |
| » Defeated Twins (60-54), 3-2 | Cleveland Stadium (35-25) | 56-61 | Won 4 |
| » Starters: Dave Goltz vs Gaylord Perry | Fifth | 6½ out |
| Future Indian Steve Kline is born in Sunbury, PA. |
| Wednesday, August 23 |
| » Defeated Twins (60-55), 5-1 | Cleveland Stadium (36-25) | 57-61 | Won 5 |
| » Starters: Dick Woodson vs Steve Dunning | Fifth | 6½ out |
| Friday, August 25 |
| » Defeated Angels (52-67), 2-1 | Anaheim Stadium (2-2) | 58-61 | Won 6 |
| » Starters: Dick Tidrow vs Clyde Wright | Fourth | 6 out |
| Saturday, August 26 |
| » Lost to Angels (53-67), 7-1 | Anaheim Stadium (2-3) | 58-62 | |
| » Starters: Gaylord Perry vs Andy Messersmith | Fourth | 7 out |
| Sunday, August 27 |
| » Lost to Angels (54-67), 1-0 | Anaheim Stadium (2-4) | 58-63 | Lost 2 |
| » Starters: Milt Wilcox vs Nolan Ryan | Fifth | 8½ out |
| Monday, August 28 |
| » Lost to Athletics (71-51), 5-4 | Oakland-Alameda County Stadium (0-4) | 58-64 | Lost 3 |
| » Starters: Steve Dunning vs Vida Blue | Fifth | 9 out |
| Tuesday, August 29 |
| » Lost to Athletics (72-51), 1-0 | Oakland-Alameda County Stadium (0-5) | 58-65 | Lost 4 |
| » Starters: Dick Tidrow vs Catfish Hunter | Fourth | 9 out |
| Wednesday, August 30 |
| » Lost to Athletics (73-51), 2-0 | Oakland-Alameda County Stadium (0-6) | 58-66 | Lost 5 |
| » Starters: Gaylord Perry vs Blue Moon Odom | Fourth | 9 out |
| Friday, September 1 |
| » Lost to Twins (62-60), 5-4 | Metropolitan Stadium (1-3) | 58-67 | Lost 6 |
| » Starters: Milt Wilcox vs Dave Goltz | Fourth | 10 out |
| Saturday, September 2 |
| » Defeated Twins (62-61), 5-3 | Metropolitan Stadium (2-3) | 59-67 | |
| » Starters: Steve Dunning vs Dick Woodson | Fourth | 9 out |
| Sunday, September 3 |
| » Defeated Twins (62-62), 4-1 | Metropolitan Stadium (3-3) | 60-67 | Won 2 |
| » Starters: Dick Tidrow vs Jim Perry | Fourth | 8 out |
| Monday, September 4 |
| » Lost to Tigers (69-60), 2-1 | Tiger Stadium (5-3) | 60-68 | |
| » Starters: Gaylord Perry vs Woodie Fryman | Fourth | 8½ out |
| Tuesday, September 5 |
| » Lost to Tigers (70-60), 4-2 | Tiger Stadium (5-4) | 60-69 | Lost 2 |
| » Starters: Marcelino Lopez vs Joe Coleman | Fifth | 9½ out |
| » Major-league debuts: Joe Staton (Tigers) |
| Wednesday, September 6 |
| » Defeated Brewers (52-79), 4-3 | Cleveland Stadium (37-25) | 61-69 | |
| » Starters: Jim Colborn vs Steve Dunning | Fifth | 10 out |
| » Lost to Brewers (53-79), 5-2 | Cleveland Stadium (37-26) | 61-70 | |
| » Starters: Jerry Bell vs Milt Wilcox | Fifth | 10 out |
| Thursday, September 7 |
| » Lost to Brewers (54-79), 7-1 | Cleveland Stadium (37-27) | 61-71 | Lost 2 |
| » Starters: Bill Parsons vs Dick Tidrow | Fifth | 10½ out |
| Saturday, September 9 |
| » Defeated Red Sox (71-60), 2-1 | Cleveland Stadium (38-27) | 62-71 | |
| » Starters: Lynn McGlothen vs Gaylord Perry | Fifth | 10 out |
| Sunday, September 10 |
| » Lost to Red Sox (72-60), 5-1 | Cleveland Stadium (38-28) | 62-72 | |
| » Starters: Marty Pattin vs Marcelino Lopez | Fifth | 12 out |
| » Lost to Red Sox (73-60), 2-0 | Cleveland Stadium (38-29) | 62-73 | Lost 2 |
| » Starters: John Curtis vs Steve Dunning | Fifth | 12 out |
| Monday, September 11 |
| » Defeated Red Sox (73-61), 6-5 | Cleveland Stadium (39-29) | 63-73 | |
| » Starters: Sonny Siebert vs Dick Tidrow | Fifth | 11 out |
| Tuesday, September 12 |
| » Lost to Brewers (55-83), 4-3 | County Stadium (0-4) | 63-74 | |
| » Starters: Bill Butler vs Bill Parsons | Fourth | 11½ out |
| » Lost to Brewers (56-83), 4-2 | County Stadium (0-5) | 63-75 | Lost 2 |
| » Starters: Milt Wilcox vs Gary Ryerson | Fourth | 11½ out |
| Wednesday, September 13 |
| » Lost to Brewers (57-83), 3-1 | County Stadium (0-6) | 63-76 | Lost 3 |
| » Starters: Gaylord Perry vs Jerry Bell | Fourth | 12½ out |
| Future Indian Chan Perry is born in Live Oak, FL. |
| Thursday, September 14 |
| » Lost to Brewers (58-83), 4-3 | County Stadium (0-7) | 63-77 | Lost 4 |
| » Starters: Ray Lamb vs Ken Brett | Fourth | 13 out |
| Future Indian David Bell is born in Cincinnati, OH. |
| Friday, September 15 |
| » Lost to Red Sox (75-62), 4-3 | Fenway Park (3-4) | 63-78 | Lost 5 |
| » Starters: Steve Dunning vs Marty Pattin | Fifth | 14 out |
| Saturday, September 16 |
| » Lost to Red Sox (76-62), 10-0 | Fenway Park (3-5) | 63-79 | Lost 6 |
| » Starters: Dick Tidrow vs Luis Tiant | Fifth | 15 out |
| » Major-league debuts: Dwight Evans (Red Sox) |
| Sunday, September 17 |
| » Defeated Red Sox (76-63), 9-2 | Fenway Park (4-5) | 64-79 | |
| » Starters: Gaylord Perry vs John Curtis | Fifth | 14 out |
| Tuesday, September 19 |
| » Defeated Tigers (77-65), 3-2 | Cleveland Stadium (40-29) | 65-79 | Won 2 |
| » Starters: Mickey Lolich vs Steve Dunning | Fourth | 12½ out |
| » Defeated Tigers (77-66), 6-4 | Cleveland Stadium (41-29) | 66-79 | Won 3 |
| » Starters: John Hiller vs Bill Butler | Fourth | 12½ out |
| Wednesday, September 20 |
| » Lost to Tigers (78-66), 4-1 | Cleveland Stadium (41-30) | 66-80 | |
| » Starters: Woodie Fryman vs Dick Tidrow | Fifth | 14 out |
| Friday, September 22 |
| » Defeated Yankees (75-70), 4-1 | Cleveland Stadium (42-30) | 67-80 | |
| » Starters: Steve Kline vs Gaylord Perry | Fifth | 13½ out |
| Saturday, September 23 |
| » Lost to Yankees (76-70), 5-2 | Cleveland Stadium (42-31) | 67-81 | |
| » Starters: Fritz Peterson vs Steve Dunning | Fifth | 13½ out |
| Sunday, September 24 |
| » Lost to Yankees (77-70), 5-4 | Cleveland Stadium (42-32) | 67-82 | Lost 2 |
| » Starters: Mel Stottlemyre vs Ray Lamb | Fifth | 15 out |
| » Lost to Yankees (78-70), 8-3 | Cleveland Stadium (42-33) | 67-83 | Lost 3 |
| » Starters: Rob Gardner vs Milt Wilcox | Fifth | 15 out |
| Tuesday, September 26 |
| » Defeated Orioles (78-70), 3-2 | Memorial Stadium (3-5) | 68-83 | |
| » Starters: Dick Tidrow vs Mike Cuellar | Fourth | 14 out |
| Wednesday, September 27 |
| » Defeated Orioles (78-71), 3-0 | Memorial Stadium (4-5) | 69-83 | Won 2 |
| » Starters: Gaylord Perry vs Dave McNally | Fourth | 14 out |
| Sunday, October 1 |
| » Defeated Yankees (79-72), 2-1 | Yankee Stadium (2-6) | 70-83 | Won 3 |
| » Starters: Gaylord Perry vs Fritz Peterson | Fourth | 14 out |
| » Defeated Yankees (79-73), 4-3 | Yankee Stadium (3-6) | 71-83 | Won 4 |
| » Starters: Steve Dunning vs Rob Gardner | Fourth | 14 out |
| Tuesday, October 3 |
| » Defeated Orioles (79-74), 6-5 | Cleveland Stadium (43-33) | 72-83 | Won 5 |
| » Starters: Doyle Alexander vs Dick Tidrow | Fifth | 14½ out |
| » Lost to Orioles (80-74), 4-3 | Cleveland Stadium (43-34) | |
