| Saturday, January 29 |
| Former Giant Heinie Stafford dies in Lake Worth, FL at the age of 81. |
| Saturday, March 4 |
| Former Giant Watty Clark dies in Clearwater, FL at the age of 70. |
| Saturday, March 11 |
| Future Giant Salomon Torres is born in San Pedro de Macoris, D.R. |
| Friday, March 24 |
| Former Giant Dick Coffman dies in Athens, AL at the age of 66. |
| Monday, April 3 |
| Future Giant Steve Soderstrom is born in Turlock, CA. |
| Saturday, April 15 |
| » Defeated Astros (0-1), 5-0 | Astrodome (1-0) | 1-0 | |
| » Starters: Juan Marichal vs Don Wilson | First | -- |
| Sunday, April 16 |
| » Defeated Astros (0-2), 10-6 | Astrodome (2-0) | 2-0 | Won 2 |
| » Starters: Sam McDowell vs Dave Roberts | First | -- |
| Monday, April 17 |
| » Lost to Astros (1-2), 7-2 | Astrodome (2-1) | 2-1 | |
| » Starters: John Cumberland vs Larry Dierker | First | -- |
| Tuesday, April 18 |
| » Defeated Padres (2-2), 5-1 | San Diego/Jack Murphy Stadium (1-0) | 3-1 | |
| » Starters: Don Carrithers vs Tom Phoebus | First | -- |
| Wednesday, April 19 |
| » Lost to Padres (3-2), 4-3 | San Diego/Jack Murphy Stadium (1-1) | 3-2 | |
| » Starters: Juan Marichal vs Clay Kirby | Second | 1 out |
| Thursday, April 20 |
| » Defeated Padres (3-3), 2-1 | San Diego/Jack Murphy Stadium (2-1) | 4-2 | |
| » Starters: Sam McDowell vs Steve Arlin | Second | 1 out |
| Friday, April 21 |
| » Lost to Astros (4-2), 7-3 | Candlestick Park (0-1) | 4-3 | |
| » Starters: Don Wilson vs John Cumberland | Third | 2 out |
| Future Giant Keith Williams is born in Bedford, PA. |
| Saturday, April 22 |
| » Lost to Astros (5-2), 6-0 | Candlestick Park (0-2) | 4-4 | Lost 2 |
| » Starters: Dave Roberts vs Don Carrithers | Third | 3 out |
| Sunday, April 23 |
| » Lost to Astros (6-2), 13-7 | Candlestick Park (0-3) | 4-5 | Lost 3 |
| » Starters: Larry Dierker vs Steve Stone | Third | 3 out |
| Tuesday, April 25 |
| » Lost to Phillies (5-3), 3-0 | Candlestick Park (0-4) | 4-6 | Lost 4 |
| » Starters: Steve Carlton vs Juan Marichal | Second | 4 out |
| » Major-league debuts: Garry Maddox (Giants) |
| Wednesday, April 26 |
| » Defeated Phillies (5-4), 8-6 | Candlestick Park (1-4) | 5-6 | |
| » Starters: Bill Champion vs Sam McDowell | Second | 4 out |
| Thursday, April 27 |
| » Lost to Phillies (6-4), 7-6 | Candlestick Park (1-5) | 5-7 | |
| » Starters: Dick Selma vs John Cumberland | Third | 4½ out |
| Future Giant Chad Zerbe is born in Findlay, OH. |
| Friday, April 28 |
| » Lost to Expos (7-3), 8-6 | Candlestick Park (1-6) | 5-8 | Lost 2 |
| » Starters: Steve Renko vs Don Carrithers | Third | 4½ out |
| Saturday, April 29 |
| » Lost to Expos (8-3), 2-1 | Candlestick Park (1-7) | 5-9 | Lost 3 |
| » Starters: Mike Torrez vs Steve Stone | Fifth | 5 out |
| Sunday, April 30 |
| » Lost to Expos (9-3), 5-2 | Candlestick Park (1-8) | 5-10 | Lost 4 |
| » Starters: Carl Morton vs Juan Marichal | Fifth | 5½ out |
| » Defeated Expos (9-4), 13-2 | Candlestick Park (2-8) | 6-10 | |
| » Starters: Bill Stoneman vs Sam McDowell | Fifth | 5½ out |
| » Major-league debuts: Joe Gilbert (Expos) |
| Monday, May 1 |
| » Lost to Mets (9-4), 7-4 | Candlestick Park (2-9) | 6-11 | |
| » Starters: Tom Seaver vs John Cumberland | Fifth | 6 out |
| Tuesday, May 2 |
| » Lost to Mets (10-4), 4-2 | Candlestick Park (2-10) | 6-12 | Lost 2 |
| » Starters: Gary Gentry vs Don Carrithers | Sixth | 6½ out |
| Wednesday, May 3 |
| » Lost to Mets (11-4), 8-5 | Candlestick Park (2-11) | 6-13 | Lost 3 |
| » Starters: Jon Matlack vs Steve Stone | Sixth | 6½ out |
| Friday, May 5 |
| » Lost to Phillies (12-6), 3-2 | Veteran's Stadium (0-1) | 6-14 | Lost 4 |
| » Starters: Juan Marichal vs Bill Champion | Fifth | 7½ out |
| Saturday, May 6 |
| » Defeated Phillies (12-7), 3-1 | Veteran's Stadium (1-1) | 7-14 | |
| » Starters: Sam McDowell vs Dick Selma | Sixth | 6½ out |
| Sunday, May 7 |
| » Lost to Phillies (13-7), 8-3 | Veteran's Stadium (1-2) | 7-15 | |
| » Starters: Ron Bryant vs Steve Carlton | Sixth | 7 out |
| Tuesday, May 9 |
| » Lost to Expos (12-7), 7-1 | Parc Jarry (0-1) | 7-16 | Lost 2 |
| » Starters: Juan Marichal vs Mike Torrez | Sixth | 7 out |
| Wednesday, May 10 |
| » Defeated Expos (12-8), 7-3 | Parc Jarry (1-1) | 8-16 | |
| » Starters: Sam McDowell vs Bill Stoneman | Sixth | 7 out |
| Thursday, May 11 |
| » Defeated Expos (12-9), 6-2 | Parc Jarry (2-1) | 9-16 | Won 2 |
| » Starters: Ron Bryant vs Steve Renko | Sixth | 6 out |
| Friday, May 12 |
| » Lost to Mets (15-7), 2-1 | Shea Stadium (0-1) | 9-17 | |
| » Starters: Steve Stone vs Gary Gentry | Sixth | 6½ out |
| Saturday, May 13 |
| » Lost to Mets (16-7), 1-0 | Shea Stadium (0-2) | 9-18 | Lost 2 |
| » Starters: Juan Marichal vs Buzz Capra | Sixth | 7½ out |
| Sunday, May 14 |
| » Lost to Mets (17-7), 5-4 | Shea Stadium (0-3) | 9-19 | Lost 3 |
| » Starters: Sam McDowell vs Ray Sadecki | Sixth | 8 out |
| Tuesday, May 16 |
| » Lost to Reds (13-13), 4-3 | Candlestick Park (2-12) | 9-20 | Lost 4 |
| » Starters: Gary Nolan vs Ron Bryant | Sixth | 10 out |
| » Lost to Reds (14-13), 2-0 | Candlestick Park (2-13) | 9-21 | Lost 5 |
| » Starters: Jack Billingham vs Steve Stone | Sixth | 10 out |
| Wednesday, May 17 |
| » Lost to Reds (15-13), 2-1 | Candlestick Park (2-14) | 9-22 | Lost 6 |
| » Starters: Ross Grimsley vs Juan Marichal | Sixth | 10 out |
| Thursday, May 18 |
| » Lost to Reds (16-13), 8-5 | Candlestick Park (2-15) | 9-23 | Lost 7 |
| » Starters: Wayne Simpson vs Sam McDowell | Sixth | 11 out |
| Friday, May 19 |
| » Defeated Braves (10-19), 7-6 | Candlestick Park (3-15) | 10-23 | |
| » Starters: Phil Niekro vs John Cumberland | Sixth | 10 out |
| Saturday, May 20 |
| » Lost to Braves (11-19), 3-2 | Candlestick Park (3-16) | 10-24 | |
| » Starters: Tom Kelley vs Steve Stone | Sixth | 11 out |
| Sunday, May 21 |
| » Lost to Braves (12-19), 6-4 | Candlestick Park (3-17) | 10-25 | Lost 2 |
| » Starters: Ron Schueler vs Juan Marichal | Sixth | 10½ out |
| » Defeated Braves (12-20), 2-1 | Candlestick Park (4-17) | 11-25 | |
| » Starters: Ron Reed vs Ron Bryant | Sixth | 10½ out |
| Monday, May 22 |
| » Defeated Dodgers (20-14), 9-8 | Dodger Stadium (1-0) | 12-25 | Won 2 |
| » Starters: Sam McDowell vs Tommy John | Sixth | 10½ out |
| Tuesday, May 23 |
| » Lost to Dodgers (21-14), 8-5 | Dodger Stadium (1-1) | 12-26 | |
| » Starters: John Cumberland vs Don Sutton | Sixth | 12 out |
| Wednesday, May 24 |
| » Defeated Dodgers (21-15), 1-0 | Dodger Stadium (2-1) | 13-26 | |
| » Starters: Steve Stone vs Claude Osteen | Sixth | 12 out |
| Friday, May 26 |
| » Lost to Braves (15-20), 9-4 | Atlanta-Fulton County Stadium (0-1) | 13-27 | |
| » Starters: Juan Marichal vs Ron Reed | Sixth | 13 out |
| Saturday, May 27 |
| » Defeated Braves (15-21), 11-9 | Atlanta-Fulton County Stadium (1-1) | 14-27 | |
| » Starters: Sam McDowell vs Phil Niekro | Sixth | 12 out |
| Sunday, May 28 |
| » Defeated Braves (15-22), 3-2 | Atlanta-Fulton County Stadium (2-1) | 15-27 | Won 2 |
| » Starters: Steve Stone vs Ron Schueler | Sixth | 11½ out |
| » Lost to Braves (16-22), 7-6 | Atlanta-Fulton County Stadium (2-2) | 15-28 | |
| » Starters: Ron Bryant vs Tom Kelley | Sixth | 11½ out |
| Future Giant Joe Rosselli is born in Burbank, CA. |
| Monday, May 29 |
| » Lost to Dodgers (24-16), 5-2 | Candlestick Park (4-18) | 15-29 | Lost 2 |
| » Starters: Don Sutton vs Charlie Williams | Sixth | 11½ out |
| Tuesday, May 30 |
| » Lost to Dodgers (25-16), 5-3 | Candlestick Park (4-19) | 15-30 | Lost 3 |
| » Starters: Claude Osteen vs Sam McDowell | Sixth | 12 out |
| Wednesday, May 31 |
| » Lost to Dodgers (26-16), 5-4 | Candlestick Park (4-20) | 15-31 | Lost 4 |
| » Starters: Al Downing vs Ron Bryant | Sixth | 13 out |
| Thursday, June 1 |
| » Defeated Dodgers (26-17), 5-2 | Candlestick Park (5-20) | 16-31 | |
| » Starters: Bill Singer vs Steve Stone | Fifth | 12 out |
| Friday, June 2 |
| » Defeated Pirates (24-16), 7-4 | Candlestick Park (6-20) | 17-31 | Won 2 |
| » Starters: Bob Johnson vs Juan Marichal | Fifth | 12 out |
| Saturday, June 3 |
| » Lost to Pirates (25-16), 4-3 | Candlestick Park (6-21) | 17-32 | |
| » Starters: Steve Blass vs Sam McDowell | Sixth | 13 out |
| Sunday, June 4 |
| » Lost to Pirates (26-16), 4-3 | Candlestick Park (6-22) | 17-33 | Lost 2 |
| » Starters: Luke Walker vs Ron Bryant | Sixth | 13½ out |
| » Lost to Pirates (27-16), 9-1 | Candlestick Park (6-23) | 17-34 | Lost 3 |
| » Starters: Bruce Kison vs Charlie Williams | Sixth | 13½ out |
| Tuesday, June 6 |
| » Lost to Cardinals (18-28), 5-3 | Candlestick Park (6-24) | 17-35 | Lost 4 |
| » Starters: Rick Wise vs Steve Stone | Fifth | 14½ out |
| Wednesday, June 7 |
| » Lost to Cardinals (19-28), 6-0 | Candlestick Park (6-25) | 17-36 | Lost 5 |
| » Starters: Reggie Cleveland vs Juan Marichal | Sixth | 14½ out |
| Thursday, June 8 |
| » Lost to Cardinals (20-28), 6-4 | Candlestick Park (6-26) | 17-37 | Lost 6 |
| » Starters: Scipio Spinks vs Sam McDowell | Sixth | 15½ out |
| Saturday, June 10 |
| » Lost to Cubs (26-20), 4-2 | Candlestick Park (6-27) | 17-38 | Lost 7 |
| » Starters: Fergie Jenkins vs Steve Stone | Sixth | 16 out |
| Sunday, June 11 |
| » Lost to Cubs (27-20), 4-0 | Candlestick Park (6-28) | 17-39 | Lost 8 |
| » Starters: Bill Hands vs Juan Marichal | Sixth | 16½ out |
| » Defeated Cubs (27-21), 3-1 | Candlestick Park (7-28) | 18-39 | |
| » Starters: Burt Hooton vs Ron Bryant | Sixth | 16½ out |
| » Major-league debuts: Randy Moffitt (Giants) |
| Wednesday, June 14 |
| » Defeated Pirates (32-18), 3-1 | Three Rivers Stadium (1-0) | 19-39 | Won 2 |
| » Starters: Sam McDowell vs Dock Ellis | Sixth | 17½ out |
| Thursday, June 15 |
| » Lost to Pirates (33-18), 4-1 | Three Rivers Stadium (1-1) | 19-40 | |
| » Starters: Steve Stone vs Nelson Briles | Sixth | 18½ out |
| » Lost to Pirates (34-18), 9-7 | Three Rivers Stadium (1-2) | 19-41 | Lost 2 |
| » Starters: Ron Bryant vs Bob Moose | Sixth | 18½ out |
| Friday, June 16 |
| » Defeated Cardinals (23-31), 6-1 | Busch Stadium II (1-0) | 20-41 | |
| » Starters: Don Carrithers vs Rick Wise | Fourth | 17½ out |
| Saturday, June 17 |
| » Lost to Cardinals (24-31), 4-3 | Busch Stadium II (1-1) | 20-42 | |
| » Starters: Ron Bryant vs Reggie Cleveland | Sixth | 18½ out |
| Sunday, June 18 |
| » Defeated Cardinals (24-32), 8-2 | Busch Stadium II (2-1) | 21-42 | |
| » Starters: Sam McDowell vs Scipio Spinks | Sixth | 17½ out |
| Monday, June 19 |
| » Lost to Cubs (33-22), 7-6 | Wrigley Field (0-1) | 21-43 | |
| » Starters: Steve Stone vs Bill Hands | Sixth | 17½ out |
| » Major-league debuts: Rick Reuschel (Cubs) |
| Tuesday, June 20 |
| » Lost to Cubs (34-22), 15-8 | Wrigley Field (0-2) | 21-44 | Lost 2 |
| » Starters: Don Carrithers vs Burt Hooton | Sixth | 18 out |
| Wednesday, June 21 |
| » Defeated Cubs (34-23), 4-0 | Wrigley Field (1-2) | 22-44 | |
| » Starters: Ron Bryant vs Milt Pappas | Sixth | 17½ out |
| Friday, June 23 |
| » Lost to Padres (21-39), 4-1 | San Diego/Jack Murphy Stadium (2-2) | 22-45 | |
| » Starters: Sam McDowell vs Steve Arlin | Sixth | 18 out |
| Saturday, June 24 |
| » Defeated Padres (21-40), 7-4 | San Diego/Jack Murphy Stadium (3-2) | 23-45 | |
| » Starters: Don Carrithers vs Bill Greif | Sixth | 17½ out |
| Sunday, June 25 |
| » Defeated Padres (21-41), 6-5 | San Diego/Jack Murphy Stadium (4-2) | 24-45 | Won 2 |
| » Starters: Jim Barr vs Fred Norman | Fifth | 17 out |
| Monday, June 26 |
| » Defeated Braves (29-33), 3-0 | Candlestick Park (8-28) | 25-45 | Won 3 |
| » Starters: Ron Reed vs Ron Bryant | Fifth | 17 out |
| Tuesday, June 27 |
| » Defeated Braves (29-34), 3-2 | Candlestick Park (9-28) | 26-45 | Won 4 |
| » Starters: Phil Niekro vs Sam McDowell | Fifth | 17 out |
| Wednesday, June 28 |
| » Lost to Reds (41-25), 4-2 | Candlestick Park (9-29) | 26-46 | |
| » Starters: Ross Grimsley vs Don Carrithers | Fifth | 18 out |
| Thursday, June 29 |
| » Defeated Reds (41-26), 3-2 | Candlestick Park (10-29) | 27-46 | |
| » Starters: Jack Billingham vs Jim Barr | Fifth | 17 out |
| Friday, June 30 |
| » Defeated Dodgers (36-32), 8-4 | Candlestick Park (11-29) | 28-46 | Won 2 |
| » Starters: Claude Osteen vs Ron Bryant | Fifth | 16 out |
| » Major-league debuts: Lee Lacy (Dodgers) |
| Saturday, July 1 |
| » Defeated Dodgers (36-33), 8-5 | Candlestick Park (12-29) | 29-46 | Won 3 |
| » Starters: Al Downing vs Sam McDowell | Fifth | 16 out |
| Sunday, July 2 |
| » Defeated Dodgers (36-34), 9-3 | Candlestick Park (13-29) | 30-46 | Won 4 |
| » Starters: Don Sutton vs Juan Marichal | Fifth | 16 out |
| Monday, July 3 |
| » Lost to Phillies (25-45), 4-2 | Veteran's Stadium (1-3) | 30-47 | |
| » Starters: Don Carrithers vs Steve Carlton | Fifth | 16 out |
| Tuesday, July 4 |
| » Defeated Phillies (25-46), 2-1 | Veteran's Stadium (2-3) | 31-47 | |
| » Starters: Jim Barr vs Bill Champion | Fifth | 16 out |
| Thursday, July 6 |
| » Defeated Phillies (25-47), 6-4 | Veteran's Stadium (3-3) | 32-47 | Won 2 |
| » Starters: Ron Bryant vs Ken Reynolds | Fifth | 15½ out |
| Friday, July 7 |
| » Lost to Expos (32-41), 7-2 | Parc Jarry (2-2) | 32-48 | |
| » Starters: Sam McDowell vs Bill Stoneman | Fifth | 15½ out |
| Saturday, July 8 |
| » Defeated Expos (32-42), 12-1 | Parc Jarry (3-2) | 33-48 | |
| » Starters: Juan Marichal vs Ernie McAnally | Fifth | 15½ out |
| Sunday, July 9 |
| » Defeated Expos (32-43), 5-1 | Parc Jarry (4-2) | 34-48 | Won 2 |
| » Starters: Steve Stone vs Carl Morton | Fifth | 14 out |
| Monday, July 10 |
| » Defeated Mets (44-32), 5-4 | Shea Stadium (1-3) | 35-48 | Won 3 |
| » Starters: Jim Barr vs Gary Gentry | Fifth | 13½ out |
| Tuesday, July 11 |
| » Defeated Mets (44-33), 6-1 | Shea Stadium (2-3) | 36-48 | Won 4 |
| » Starters: Ron Bryant vs Jerry Koosman | Fifth | 13½ out |
| Wednesday, July 12 |
| » Lost to Mets (45-33), 4-0 | Shea Stadium (2-4) | 36-49 | |
| » Starters: Sam McDowell vs Jon Matlack | Fifth | 14½ out |
| Friday, July 14 |
| » Defeated Phillies (28-53), 8-1 | Candlestick Park (14-29) | 37-49 | |
| » Starters: Ken Reynolds vs Juan Marichal | Fifth | 15 out |
| Saturday, July 15 |
| » Lost to Phillies (29-53), 11-4 | Candlestick Park (14-30) | 37-50 | |
| » Starters: Steve Carlton vs Frank Reberger | Fifth | 16 out |
| Future Giant Wilson Delgado is born in San Cristobal, D.R. |
| Sunday, July 16 |
| » Defeated Phillies (29-54), 10-7 | Candlestick Park (15-30) | 38-50 | |
| » Starters: Woodie Fryman vs Jim Barr | Fifth | 16 out |
| Monday, July 17 |
| Former Giant Al Spohrer dies in Plymouth, NH at the age of 70. |
| Tuesday, July 18 |
| » Defeated Expos (36-46), 3-0 | Candlestick Park (16-30) | 39-50 | Won 2 |
| » Starters: Balor Moore vs Ron Bryant | Fifth | 15½ out |
| Wednesday, July 19 |
| » Lost to Expos (37-46), 3-2 | Candlestick Park (16-31) | 39-51 | |
| » Starters: Mike Torrez vs Juan Marichal | Fifth | 16½ out |
| Friday, July 21 |
| » Lost to Mets (49-36), 3-1 | Candlestick Park (16-32) | 39-52 | Lost 2 |
| » Starters: Jerry Koosman vs Jim Barr | Fifth | 17½ out |
| Saturday, July 22 |
| » Defeated Mets (49-37), 2-1 | Candlestick Park (17-32) | 40-52 | |
| » Starters: Jon Matlack vs Frank Reberger | Fifth | 17½ out |
| Sunday, July 23 |
| » Defeated Mets (49-38), 5-2 | Candlestick Park (18-32) | 41-52 | Won 2 |
| » Starters: Tom Seaver vs Ron Bryant | Fifth | 16½ out |
| Friday, July 28 |
| » Lost to Braves (43-49), 4-3 | Atlanta-Fulton County Stadium (2-3) | 41-53 | |
| » Starters: Ron Bryant vs Ron Schueler | Fifth | 17 out |
| Saturday, July 29 |
| » Defeated Braves (43-50), 5-2 | Atlanta-Fulton County Stadium (3-3) | 42-53 | |
| » Starters: Frank Reberger vs Phil Niekro | Fifth | 16 out |
| Sunday, July 30 |
| » Lost to Reds (57-35), 4-0 | Riverfront Stadium (0-1) | 42-54 | |
| » Starters: Juan Marichal vs Ross Grimsley | Fifth | 16 out |
| » Defeated Reds (57-36), 6-1 | Riverfront Stadium (1-1) | 43-54 | |
| » Starters: Jim Barr vs Tom Hall | Fifth | 16 out |
| Monday, July 31 |
| » Defeated Reds (57-37), 7-2 | Riverfront Stadium (2-1) | 44-54 | Won 2 |
| » Starters: Don Carrithers vs Jack Billingham | Fifth | 15 out |
| Tuesday, August 1 |
| » Defeated Dodgers (49-47), 4-3 | Dodger Stadium (3-1) | 45-54 | Won 3 |
| » Starters: Ron Bryant vs Al Downing | Fifth | 15 out |
| Wednesday, August 2 |
| » Lost to Dodgers (50-47), 12-11 | Dodger Stadium (3-2) | 45-55 | |
| » Starters: Steve Stone vs Don Sutton | Fifth | 15 out |
| » Major-league debuts: Steve Yeager (Dodgers) |
| Thursday, August 3 |
| » Lost to Dodgers (51-47), 3-0 | Dodger Stadium (3-3) | 45-56 | Lost 2 |
| » Starters: Frank Reberger vs Tommy John | Fifth | 15½ out |
| Friday, August 4 |
| » Lost to Astros (56-45), 6-1 | Candlestick Park (18-33) | 45-57 | Lost 3 |
| » Starters: Jerry Reuss vs Juan Marichal | Fifth | 17 out |
| Future Giant Steve Bourgeois is born in Lutcher, LA. |
| Saturday, August 5 |
| » Lost to Astros (57-45), 4-3 | Candlestick Park (18-34) | 45-58 | Lost 4 |
| » Starters: Dave Roberts vs Don Carrithers | Fifth | 18 out |
| Sunday, August 6 |
| » Lost to Astros (58-45), 7-3 | Candlestick Park (18-35) | 45-59 | Lost 5 |
| » Starters: Larry Dierker vs Jim Barr | Fifth | 17½ out |
| » Defeated Astros (58-46), 6-2 | Candlestick Park (19-35) | 46-59 | |
| » Starters: Tom Griffin vs Jim Willoughby | Fifth | 17½ out |
| Tuesday, August 8 |
| » Defeated Padres (41-62), 15-4 | Candlestick Park (20-35) | 47-59 | Won 2 |
| » Starters: Steve Arlin vs Frank Reberger | Fifth | 17½ out |
| » Defeated Padres (41-63), 7-3 | Candlestick Park (21-35) | 48-59 | Won 3 |
| » Starters: Bill Greif vs Steve Stone | Fifth | 17½ out |
| Wednesday, August 9 |
| » Lost to Padres (42-63), 5-2 | Candlestick Park (21-36) | 48-60 | |
| » Starters: Clay Kirby vs Juan Marichal | Fifth | 18½ out |
| Friday, August 11 |
| » Lost to Astros (60-48), 6-3 | Astrodome (2-2) | 48-61 | Lost 2 |
| » Starters: Don Carrithers vs Larry Dierker | Fifth | 18 out |
| Saturday, August 12 |
| » Lost to Astros (61-48), 3-1 | Astrodome (2-3) | 48-62 | Lost 3 |
| » Starters: Jim Barr vs Don Wilson | Fifth | 18 out |
| Sunday, August 13 |
| » Defeated Astros (61-49), 4-3 | Astrodome (3-3) | 49-62 | |
| » Starters: Jim Willoughby vs Jerry Reuss | Fifth | 18 out |
| Monday, August 14 |
| » Lost to Astros (62-49), 7-5 | Astrodome (3-4) | 49-63 | |
| » Starters: Frank Reberger vs Dave Roberts | Fifth | 19 out |
| Tuesday, August 15 |
| » Defeated Cubs (58-53), 7-5 | Candlestick Park (22-36) | 50-63 | |
| » Starters: Bill Hands vs Juan Marichal | Fifth | 19 out |
| Wednesday, August 16 |
| » Defeated Cubs (58-54), 14-9 | Candlestick Park (23-36) | 51-63 | Won 2 |
| » Starters: Rick Reuschel vs Don Carrithers | Fifth | 19 out |
| Thursday, August 17 |
| » Lost to Cubs (59-54), 2-1 | Candlestick Park (23-37) | 51-64 | |
| » Starters: Milt Pappas vs Jim Barr | Fifth | 19 out |
| Friday, August 18 |
| » Lost to Cardinals (54-57), 3-1 | Candlestick Park (23-38) | 51-65 | Lost 2 |
| » Starters: Don Durham vs Jim Willoughby | Fifth | 20 out |
| Saturday, August 19 |
| » Lost to Cardinals (55-57), 7-4 | Candlestick Park (23-39) | 51-66 | Lost 3 |
| » Starters: Al Santorini vs Frank Reberger | Fifth | 21 out |
| Sunday, August 20 |
| » Defeated Cardinals (55-58), 5-3 | Candlestick Park (24-39) | 52-66 | |
| » Starters: Reggie Cleveland vs Ron Bryant | Fourth | 21 out |
| Tuesday, August 22 |
| » Lost to Pirates (73-42), 1-0 | Candlestick Park (24-40) | 52-67 | |
| » Starters: Nelson Briles vs Juan Marichal | Fifth | 22½ out |
| Wednesday, August 23 |
| » Defeated Pirates (73-43), 8-0 | Candlestick Park (25-40) | 53-67 | |
| » Starters: Bob Moose vs Jim Barr | Fifth | 21½ out |
| Friday, August 25 |
| » Defeated Cubs (63-57), 11-2 | Wrigley Field (2-2) | 54-67 | Won 2 |
| » Starters: Jim Willoughby vs Rick Reuschel | Fifth | 22 out |
| Saturday, August 26 |
| » Lost to Cubs (64-57), 10-9 | Wrigley Field (2-3) | 54-68 | |
| » Starters: Ron Bryant vs Fergie Jenkins | Fifth | 22 out |
| Sunday, August 27 |
| » Lost to Cubs (65-57), 9-3 | Wrigley Field (2-4) | 54-69 | Lost 2 |
| » Starters: Frank Reberger vs Bill Hands | Fifth | 23 out |
| » Major-league debuts: Jim Tyrone (Cubs) |
| Monday, August 28 |
| » Lost to Cardinals (60-61), 4-2 | Busch Stadium II (2-2) | 54-70 | Lost 3 |
| » Starters: Juan Marichal vs Don Durham | Fifth | 24 out |
| Tuesday, August 29 |
| » Defeated Cardinals (60-62), 3-0 | Busch Stadium II (3-2) | 55-70 | |
| » Starters: Jim Barr vs Reggie Cleveland | Fifth | 23 out |
| Wednesday, August 30 |
| » Defeated Cardinals (60-63), 3-2 | Busch Stadium II (4-2) | 56-70 | Won 2 |
| » Starters: Jim Willoughby vs Bob Gibson | Fifth | 23 out |
| Friday, September 1 |
| » Lost to Pirates (78-46), 10-6 | Three Rivers Stadium (1-3) | 56-71 | |
| » Starters: Ron Bryant vs Dock Ellis | Fifth | 24 out |
| Saturday, September 2 |
| » Lost to Pirates (79-46), 6-3 | Three Rivers Stadium (1-4) | 56-72 | Lost 2 |
| » Starters: Sam McDowell vs Nelson Briles | Fifth | 24 out |
| Sunday, September 3 |
| » Lost to Pirates (80-46), 2-1 | Three Rivers Stadium (1-5) | 56-73 | Lost 3 |
| » Starters: Jim Barr vs Bob Moose | Fifth | 25 out |
| Monday, September 4 |
| » Lost to Padres (48-80), 1-0 | San Diego/Jack Murphy Stadium (4-3) | 56-74 | Lost 4 |
| » Starters: Jim Willoughby vs Mike Corkins | Fifth | 25½ out |
| Former Giant Bob Bowman dies in Bluefield, WV at the age of 62. |
| Tuesday, September 5 |
| » Defeated Padres (48-81), 4-3 | San Diego/Jack Murphy Stadium (5-3) | 57-74 | |
| » Starters: Frank Reberger vs Steve Arlin | Fifth | 24½ out |
| » Major-league debuts: Gary Thomasson (Giants) |
| Wednesday, September 6 |
| » Defeated Padres (48-82), 6-0 | San Diego/Jack Murphy Stadium (6-3) | 58-74 | Won 2 |
| » Starters: Ron Bryant vs Bill Greif | Fifth | 24½ out |
| » Major-league debuts: Gary Matthews (Giants) |
| Thursday, September 7 |
| » Lost to Astros (74-58), 5-1 | Candlestick Park (25-41) | 58-75 | |
| » Starters: Don Wilson vs Sam McDowell | Fifth | 24 out |
| Friday, September 8 |
| » Lost to Astros (75-58), 5-3 | Candlestick Park (25-42) | 58-76 | Lost 2 |
| » Starters: Larry Dierker vs Jim Barr | Fifth | 24½ out |
| » Major-league debuts: Elias Sosa (Giants) |
| Saturday, September 9 |
| » Defeated Reds (82-52), 2-1 | Candlestick Park (26-42) | 59-76 | |
| » Starters: Don Gullett vs Jim Willoughby | Fifth | 23½ out |
| Future Giant Felix Rodriguez is born in Monte Cristi, D.R. |
| Sunday, September 10 |
| » Lost to Reds (83-52), 8-7 | Candlestick Park (26-43) | 59-77 | |
| » Starters: Ross Grimsley vs Frank Reberger | Fifth | 23½ out |
| » Defeated Reds (83-53), 8-2 | Candlestick Park (27-43) | 60-77 | |
| » Starters: Jim McGlothlin vs Juan Marichal | Fifth | 23½ out |
| Tuesday, September 12 |
| » Defeated Dodgers (73-64), 3-2 | Candlestick Park (28-43) | 61-77 | Won 2 |
| » Starters: Tommy John vs Ron Bryant | Fifth | 23½ out |
| » Major-league debuts: Terry McDermott (Dodgers) |
| Wednesday, September 13 |
| » Defeated Dodgers (73-65), 7-1 | Candlestick Park (29-43) | 62-77 | Won 3 |
| » Starters: Bill Singer vs Jim Barr | Fifth | 23½ out |
| Thursday, September 14 |
| Future Giant David Bell is born in Cincinnati, OH. |
| Saturday, September 16 |
| » Defeated Braves (64-76), 8-5 | Atlanta-Fulton County Stadium (4-3) | 63-77 | Won 4 |
| » Starters: Jim Willoughby vs Ron Reed | Fifth | 23½ out |
| » Lost to Braves (65-76), 5-2 | Atlanta-Fulton County Stadium (4-4) | 63-78 | |
| » Starters: Frank Reberger vs Phil Niekro | Fifth | 23½ out |
| Sunday, September 17 |
| » Lost to Braves (66-76), 7-4 | Atlanta-Fulton County Stadium (4-5) | 63-79 | Lost 2 |
| » Starters: Ron Bryant vs Jimmy Freeman | Fifth | 23½ out |
| Monday, September 18 |
| » Lost to Reds (87-55), 2-0 | Riverfront Stadium (2-2) | 63-80 | Lost 3 |
| » Starters: Jim Barr vs Jim McGlothlin | Fifth | 24½ out |
| Tuesday, September 19 |
| » Lost to Reds (88-55), 5-4 | Riverfront Stadium (2-3) | 63-81 | Lost 4 |
| » Starters: Sam McDowell vs Jack Billingham | Fifth | 25½ out |
| Wednesday, September 20 |
| » Lost to Reds (89-55), 8-6 | Riverfront Stadium (2-4) | 63-82 | Lost 5 |
| » Starters: Don Carrithers vs Don Gullett | Fifth | 26½ out |
| Friday, September 22 |
| » Lost to Dodgers (78-67), 1-0 | Dodger Stadium (3-4) | 63-83 | Lost 6 |
| » Starters: Jim Willoughby vs Don Sutton | Fifth | 27½ out |
| » Major-league debuts: Davey Lopes (Dodgers) |
| Saturday, September 23 |
| » Lost to Dodgers (79-67), 7-4 | Dodger Stadium (3-5) | 63-84 | Lost 7 |
| » Starters: Ron Bryant vs Tommy John | Fifth | 27½ out |
| Sunday, September 24 |
| » Lost to Dodgers (80-67), 7-0 | Dodger Stadium (3-6) | 63-85 | Lost 8 |
| » Starters: Jim Barr vs Al Downing | Fifth | 28½ out |
| Tuesday, September 26 |
| » Defeated Astros (81-66), 5-2 | Astrodome (4-4) | 64-85 | |
| » Starters: Sam McDowell vs Jerry Reuss | Fifth | 27½ out |
| Wednesday, September 27 |
| » Lost to Astros (82-66), 3-0 | Astrodome (4-5) | 64-86 | |
| » Starters: Jim Willoughby vs Don Wilson | Fifth | 27½ out |
| Friday, September 29 |
| » Defeated Braves (70-80), 14-3 | Candlestick Park (30-43) | 65-86 | |
| » Starters: Jimmy Freeman vs Ron Bryant | Fifth | 27½ out |
| Saturday, September 30 |
| » Defeated Braves (70-81), 3-1 | Candlestick Park (31-43) | 66-86 | Won 2 |
| » Starters: Mike McQueen vs Jim Barr | Fifth | 26½ out |
| Sunday, October 1 |
| » Defeated Braves (70-82), 6-2 | Candlestick Park (32-43) | 67-86 | Won 3 |
| » Starters: George Stone vs Sam McDowell | Fifth | 26½ out |
| Tuesday, October 3 |
| » Defeated Padres (58-94), 7-4 | Candlestick Park (33-43) | 68-86 | Won 4 |
| » Starters: Mike Caldwell vs Jim Willoughby | Fifth | 26½ out |
| Wednesday, October 4 |
| » Defeated Padres (58-95), 6-4 | Candlestick Park (34-43) | 69-86 | Won 5 |
| » Starters: Fred Norman vs Ron Bryant | Fifth | 26½ out |
| Monday, October 9 |
| Former Giant Dave Bancroft dies in Superior, WI at the age of 82. |
| Tuesday, October 10 |
| Future Giant Ramon Martinez is born in Philadelphia, PA. |
| Monday, October 16 |
| Former Giant Johnny Rawlings dies in Inglewood, CA at the age of 81. |
| Thursday, October 19 |
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