| Sunday, January 9 |
| Future Astro Jay Powell is born in Meridian, MS. |
| Tuesday, February 22 |
| Future Astro John Halama is born in Brooklyn, NY. |
| Saturday, April 15 |
| » Lost to Giants (1-0), 5-0 | Astrodome (0-1) | 0-1 | |
| » Starters: Juan Marichal vs Don Wilson | Second | 1 out |
| Sunday, April 16 |
| » Lost to Giants (2-0), 10-6 | Astrodome (0-2) | 0-2 | Lost 2 |
| » Starters: Sam McDowell vs Dave Roberts | Fifth | 2 out |
| Monday, April 17 |
| » Defeated Giants (2-1), 7-2 | Astrodome (1-2) | 1-2 | |
| » Starters: John Cumberland vs Larry Dierker | Third | 1 out |
| Tuesday, April 18 |
| » Defeated Reds (1-2), 8-4 | Riverfront Stadium (1-0) | 2-2 | Won 2 |
| » Starters: Ken Forsch vs Don Gullett | Second | 1 out |
| Wednesday, April 19 |
| » Defeated Reds (1-3), 7-5 | Riverfront Stadium (2-0) | 3-2 | Won 3 |
| » Starters: Jerry Reuss vs Jack Billingham | Second | 1 out |
| Friday, April 21 |
| » Defeated Giants (4-3), 7-3 | Candlestick Park (1-0) | 4-2 | Won 4 |
| » Starters: Don Wilson vs John Cumberland | Second | 1½ out |
| Saturday, April 22 |
| » Defeated Giants (4-4), 6-0 | Candlestick Park (2-0) | 5-2 | Won 5 |
| » Starters: Dave Roberts vs Don Carrithers | Second | 1½ out |
| Sunday, April 23 |
| » Defeated Giants (4-5), 13-7 | Candlestick Park (3-0) | 6-2 | Won 6 |
| » Starters: Larry Dierker vs Steve Stone | Second | ½ out |
| Monday, April 24 |
| » Defeated Cubs (2-7), 3-2 | Astrodome (2-2) | 7-2 | Won 7 |
| » Starters: Fergie Jenkins vs Ken Forsch | First | -- |
| Tuesday, April 25 |
| » Defeated Cubs (2-8), 5-4 | Astrodome (3-2) | 8-2 | Won 8 |
| » Starters: Burt Hooton vs Jerry Reuss | First | -- |
| Wednesday, April 26 |
| » Defeated Cubs (2-9), 5-4 | Astrodome (4-2) | 9-2 | Won 9 |
| » Starters: Juan Pizarro vs Dave Roberts | First | -- |
| » Major-league debuts: Bobby Fenwick (Astros) |
| Friday, April 28 |
| » Lost to Cardinals (4-7), 7-2 | Astrodome (4-3) | 9-3 | |
| » Starters: Reggie Cleveland vs Larry Dierker | First | -- |
| Saturday, April 29 |
| » Lost to Cardinals (5-7), 4-2 | Astrodome (4-4) | 9-4 | Lost 2 |
| » Starters: Scipio Spinks vs Ken Forsch | Second | ½ out |
| Sunday, April 30 |
| » Defeated Cardinals (5-8), 7-6 | Astrodome (5-4) | 10-4 | |
| » Starters: Bob Gibson vs Don Wilson | Second | ½ out |
| Monday, May 1 |
| » Defeated Pirates (5-9), 9-8 | Three Rivers Stadium (1-0) | 11-4 | Won 2 |
| » Starters: Dave Roberts vs Steve Blass | First | -- |
| Wednesday, May 3 |
| » Lost to Pirates (6-9), 3-2 | Three Rivers Stadium (1-1) | 11-5 | |
| » Starters: Jerry Reuss vs Dock Ellis | First | -- |
| Friday, May 5 |
| » Defeated Cubs (7-11), 3-0 | Wrigley Field (1-0) | 12-5 | |
| » Starters: Larry Dierker vs Burt Hooton | First | -- |
| Saturday, May 6 |
| » Lost to Cubs (8-11), 6-4 | Wrigley Field (1-1) | 12-6 | |
| » Starters: Ken Forsch vs Bill Hands | First | -- |
| Tuesday, May 9 |
| » Lost to Cardinals (9-11), 2-1 | Busch Stadium II (0-1) | 12-7 | Lost 2 |
| » Starters: Don Wilson vs Scipio Spinks | First | -- |
| Wednesday, May 10 |
| » Defeated Cardinals (9-12), 10-7 | Busch Stadium II (1-1) | 13-7 | |
| » Starters: Dave Roberts vs Bob Gibson | First | -- |
| Thursday, May 11 |
| » Lost to Cardinals (10-12), 4-3 | Busch Stadium II (1-2) | 13-8 | |
| » Starters: Jerry Reuss vs Rick Wise | First | -- |
| Friday, May 12 |
| » Lost to Pirates (10-11), 4-2 | Astrodome (5-5) | 13-9 | Lost 2 |
| » Starters: Steve Blass vs Larry Dierker | Second | 1½ out |
| Saturday, May 13 |
| » Lost to Pirates (11-11), 6-1 | Astrodome (5-6) | 13-10 | Lost 3 |
| » Starters: Bob Moose vs Ken Forsch | Second | 1½ out |
| Sunday, May 14 |
| » Defeated Pirates (11-12), 7-6 | Astrodome (6-6) | 14-10 | |
| » Starters: Nelson Briles vs Don Wilson | Second | 1 out |
| Monday, May 15 |
| » Defeated Braves (10-16), 8-2 | Astrodome (7-6) | 15-10 | Won 2 |
| » Starters: Tom Kelley vs Dave Roberts | Second | 1 out |
| Tuesday, May 16 |
| » Defeated Braves (10-17), 6-5 | Astrodome (8-6) | 16-10 | Won 3 |
| » Starters: Ron Schueler vs Jerry Reuss | Second | 1 out |
| Wednesday, May 17 |
| » Defeated Braves (10-18), 9-0 | Astrodome (9-6) | 17-10 | Won 4 |
| » Starters: Ron Reed vs Larry Dierker | First | -- |
| Thursday, May 18 |
| » Defeated Dodgers (18-12), 4-3 | Dodger Stadium (1-0) | 18-10 | Won 5 |
| » Starters: Ken Forsch vs Don Sutton | First | -- |
| Friday, May 19 |
| » Lost to Dodgers (19-12), 2-1 | Dodger Stadium (1-1) | 18-11 | |
| » Starters: Don Wilson vs Claude Osteen | First | -- |
| Saturday, May 20 |
| » Lost to Dodgers (20-12), 3-0 | Dodger Stadium (1-2) | 18-12 | Lost 2 |
| » Starters: Dave Roberts vs Al Downing | Second | 1 out |
| Sunday, May 21 |
| » Defeated Dodgers (20-13), 2-1 | Dodger Stadium (2-2) | 19-12 | |
| » Starters: Jerry Reuss vs Bill Singer | First | -- |
| Monday, May 22 |
| » Defeated Padres (15-19), 7-0 | San Diego/Jack Murphy Stadium (1-0) | 20-12 | Won 2 |
| » Starters: Larry Dierker vs Ed Acosta | First | -- |
| Tuesday, May 23 |
| » Defeated Padres (15-20), 7-0 | San Diego/Jack Murphy Stadium (2-0) | 21-12 | Won 3 |
| » Starters: Tom Griffin vs Clay Kirby | First | -- |
| » Defeated Padres (15-21), 2-1 | San Diego/Jack Murphy Stadium (3-0) | 22-12 | Won 4 |
| » Starters: Ken Forsch vs Bill Greif | First | -- |
| Wednesday, May 24 |
| » Defeated Padres (15-22), 4-2 | San Diego/Jack Murphy Stadium (4-0) | 23-12 | Won 5 |
| » Starters: Don Wilson vs Steve Arlin | First | -- |
| Friday, May 26 |
| » Defeated Dodgers (21-16), 5-3 | Astrodome (10-6) | 24-12 | Won 6 |
| » Starters: Al Downing vs Dave Roberts | First | -- |
| Saturday, May 27 |
| » Lost to Dodgers (22-16), 7-3 | Astrodome (10-7) | 24-13 | |
| » Starters: Bill Singer vs Jerry Reuss | First | -- |
| Sunday, May 28 |
| » Lost to Dodgers (23-16), 6-5 | Astrodome (10-8) | 24-14 | Lost 2 |
| » Starters: Tommy John vs Larry Dierker | First | -- |
| Monday, May 29 |
| » Lost to Reds (21-18), 8-3 | Astrodome (10-9) | 24-15 | Lost 3 |
| » Starters: Wayne Simpson vs Ken Forsch | First | -- |
| Tuesday, May 30 |
| » Lost to Reds (22-18), 9-5 | Astrodome (10-10) | 24-16 | Lost 4 |
| » Starters: Jack Billingham vs Don Wilson | Second | ½ out |
| Wednesday, May 31 |
| » Lost to Reds (23-18), 12-4 | Astrodome (10-11) | 24-17 | Lost 5 |
| » Starters: Gary Nolan vs Dave Roberts | Second | 1½ out |
| Thursday, June 1 |
| » Lost to Reds (24-18), 10-3 | Astrodome (10-12) | 24-18 | Lost 6 |
| » Starters: Jim McGlothlin vs Jerry Reuss | Second | 1½ out |
| Friday, June 2 |
| » Defeated Expos (18-23), 7-1 | Parc Jarry (1-0) | 25-18 | |
| » Starters: Larry Dierker vs Mike Torrez | Second | 1½ out |
| Saturday, June 3 |
| » Lost to Expos (19-23), 1-0 | Parc Jarry (1-1) | 25-19 | |
| » Starters: Ken Forsch vs Bill Stoneman | Third | 2½ out |
| Sunday, June 4 |
| » Defeated Expos (19-24), 5-0 | Parc Jarry (2-1) | 26-19 | |
| » Starters: Don Wilson vs Carl Morton | Third | 1½ out |
| Tuesday, June 6 |
| » Defeated Phillies (16-29), 4-3 | Veteran's Stadium (1-0) | 27-19 | Won 2 |
| » Starters: Dave Roberts vs Woodie Fryman | Second | 1½ out |
| Wednesday, June 7 |
| » Lost to Phillies (17-29), 3-1 | Veteran's Stadium (1-1) | 27-20 | |
| » Starters: Jerry Reuss vs Steve Carlton | Third | 1½ out |
| Thursday, June 8 |
| » Lost to Phillies (18-29), 7-2 | Veteran's Stadium (1-2) | 27-21 | Lost 2 |
| » Starters: Larry Dierker vs Bill Champion | Third | 2½ out |
| Friday, June 9 |
| » Defeated Mets (32-16), 4-2 | Shea Stadium (1-0) | 28-21 | |
| » Starters: Ken Forsch vs Jon Matlack | Third | 2 out |
| Saturday, June 10 |
| » Lost to Mets (33-16), 5-3 | Shea Stadium (1-1) | 28-22 | |
| » Starters: Don Wilson vs Jerry Koosman | Third | 2½ out |
| Sunday, June 11 |
| » Defeated Mets (33-17), 4-2 | Shea Stadium (2-1) | 29-22 | |
| » Starters: Dave Roberts vs Jim McAndrew | Third | 2½ out |
| Monday, June 12 |
| » Defeated Expos (20-29), 3-1 | Astrodome (11-12) | 30-22 | Won 2 |
| » Starters: Ernie McAnally vs Jerry Reuss | Third | 2 out |
| Tuesday, June 13 |
| » Lost to Expos (21-29), 5-1 | Astrodome (11-13) | 30-23 | |
| » Starters: Mike Torrez vs Larry Dierker | Third | 3½ out |
| Wednesday, June 14 |
| » Defeated Expos (21-30), 5-4 | Astrodome (12-13) | 31-23 | |
| » Starters: Bill Stoneman vs Ken Forsch | Third | 3½ out |
| Friday, June 16 |
| » Defeated Phillies (20-34), 1-0 | Astrodome (13-13) | 32-23 | Won 2 |
| » Starters: Steve Carlton vs Don Wilson | Second | 2½ out |
| Saturday, June 17 |
| » Defeated Phillies (20-35), 10-5 | Astrodome (14-13) | 33-23 | Won 3 |
| » Starters: Woodie Fryman vs Dave Roberts | Second | 2½ out |
| Sunday, June 18 |
| » Defeated Phillies (20-36), 10-0 | Astrodome (15-13) | 34-23 | Won 4 |
| » Starters: Bill Champion vs Jerry Reuss | Second | 1½ out |
| Monday, June 19 |
| » Defeated Mets (36-21), 3-0 | Astrodome (16-13) | 35-23 | Won 5 |
| » Starters: Jon Matlack vs Larry Dierker | Second | ½ out |
| Tuesday, June 20 |
| » Defeated Mets (36-22), 7-4 | Astrodome (17-13) | 36-23 | Won 6 |
| » Starters: Jim McAndrew vs Ken Forsch | First | -- |
| Future Astro Paul Bako is born in Lafayette, LA. |
| Wednesday, June 21 |
| » Lost to Mets (37-22), 5-4 | Astrodome (17-14) | 36-24 | |
| » Starters: Jerry Koosman vs Tom Griffin | Second | ½ out |
| Thursday, June 22 |
| » Defeated Reds (36-24), 9-5 | Riverfront Stadium (3-0) | 37-24 | |
| » Starters: Dave Roberts vs Wayne Simpson | First | -- |
| Friday, June 23 |
| » Lost to Reds (37-24), 7-1 | Riverfront Stadium (3-1) | 37-25 | |
| » Starters: Jerry Reuss vs Ross Grimsley | Second | ½ out |
| Saturday, June 24 |
| » Defeated Reds (37-25), 4-1 | Riverfront Stadium (4-1) | 38-25 | |
| » Starters: Larry Dierker vs Jack Billingham | First | -- |
| Sunday, June 25 |
| » Lost to Reds (38-25), 5-4 | Riverfront Stadium (4-2) | 38-26 | |
| » Starters: Ken Forsch vs Jim McGlothlin | Second | ½ out |
| Monday, June 26 |
| » Defeated Padres (21-42), 14-7 | San Diego/Jack Murphy Stadium (5-0) | 39-26 | |
| » Starters: Don Wilson vs Clay Kirby | Second | ½ out |
| Tuesday, June 27 |
| » Defeated Padres (21-43), 6-0 | San Diego/Jack Murphy Stadium (6-0) | 40-26 | Won 2 |
| » Starters: Dave Roberts vs Steve Arlin | Second | ½ out |
| Wednesday, June 28 |
| » Lost to Dodgers (36-30), 5-0 | Dodger Stadium (2-3) | 40-27 | |
| » Starters: Jerry Reuss vs Don Sutton | Second | 1½ out |
| Thursday, June 29 |
| » Defeated Dodgers (36-31), 8-6 | Dodger Stadium (3-3) | 41-27 | |
| » Starters: Larry Dierker vs Tommy John | Second | ½ out |
| Friday, June 30 |
| » Lost to Braves (31-36), 5-2 | Astrodome (17-15) | 41-28 | |
| » Starters: Ron Reed vs Ken Forsch | Second | ½ out |
| Saturday, July 1 |
| » Defeated Braves (31-37), 4-2 | Astrodome (18-15) | 42-28 | |
| » Starters: Phil Niekro vs Don Wilson | Second | ½ out |
| Sunday, July 2 |
| » Defeated Braves (31-38), 5-4 | Astrodome (19-15) | 43-28 | Won 2 |
| » Starters: Ron Schueler vs Dave Roberts | Second | ½ out |
| Monday, July 3 |
| » Lost to Braves (32-38), 13-9 | Astrodome (19-16) | 43-29 | |
| » Starters: Jim Hardin vs Jerry Reuss | Second | ½ out |
| Tuesday, July 4 |
| » Defeated Pirates (43-26), 6-0 | Astrodome (20-16) | 44-29 | |
| » Starters: Nelson Briles vs Larry Dierker | Second | ½ out |
| Wednesday, July 5 |
| » Lost to Pirates (44-26), 6-4 | Astrodome (20-17) | 44-30 | |
| » Starters: Dock Ellis vs Ken Forsch | Second | 1 out |
| Thursday, July 6 |
| » Lost to Pirates (45-26), 7-3 | Astrodome (20-18) | 44-31 | Lost 2 |
| » Starters: Bob Moose vs Don Wilson | Second | 1½ out |
| Friday, July 7 |
| » Lost to Cardinals (39-34), 3-1 | Busch Stadium II (1-3) | 44-32 | Lost 3 |
| » Starters: Dave Roberts vs Bob Gibson | Second | 1½ out |
| Saturday, July 8 |
| » Lost to Cardinals (40-34), 2-1 | Busch Stadium II (1-4) | 44-33 | Lost 4 |
| » Starters: Jerry Reuss vs Reggie Cleveland | Second | 2½ out |
| Sunday, July 9 |
| » Defeated Cardinals (40-35), 12-6 | Busch Stadium II (2-4) | 45-33 | |
| » Starters: Larry Dierker vs Rick Wise | Second | 1 out |
| Monday, July 10 |
| » Major-league debuts: Mac Scarce (Phillies) |
| Tuesday, July 11 |
| » Defeated Cubs (41-37), 6-5 | Wrigley Field (2-1) | 46-33 | Won 2 |
| » Starters: Ken Forsch vs Burt Hooton | Second | 1½ out |
| » Lost to Cubs (42-37), 9-5 | Wrigley Field (2-2) | 46-34 | |
| » Starters: Don Wilson vs Bill Hands | Second | 1½ out |
| Wednesday, July 12 |
| » Defeated Cubs (42-38), 10-6 | Wrigley Field (3-2) | 47-34 | |
| » Starters: Dave Roberts vs Rick Reuschel | Second | 1½ out |
| Thursday, July 13 |
| » Defeated Cubs (42-39), 7-2 | Wrigley Field (4-2) | 48-34 | Won 2 |
| » Starters: Jerry Reuss vs Fergie Jenkins | Second | 1½ out |
| Friday, July 14 |
| » Lost to Pirates (49-30), 5-2 | Three Rivers Stadium (1-2) | 48-35 | |
| » Starters: Larry Dierker vs Nelson Briles | Second | 2½ out |
| Saturday, July 15 |
| » Lost to Pirates (50-30), 5-1 | Three Rivers Stadium (1-3) | 48-36 | Lost 2 |
| » Starters: Ken Forsch vs Dock Ellis | Second | 3½ out |
| Sunday, July 16 |
| » Lost to Pirates (51-30), 3-2 | Three Rivers Stadium (1-4) | 48-37 | Lost 3 |
| » Starters: Tom Griffin vs Bob Moose | Second | 5 out |
| » Lost to Pirates (52-30), 3-2 | Three Rivers Stadium (1-5) | 48-38 | Lost 4 |
| » Starters: Don Wilson vs Bruce Kison | Second | 5 out |
| Monday, July 17 |
| » Lost to Cardinals (43-39), 3-2 | Astrodome (20-19) | 48-39 | Lost 5 |
| » Starters: Bob Gibson vs Dave Roberts | Second | 6 out |
| Tuesday, July 18 |
| » Defeated Cardinals (43-40), 11-3 | Astrodome (21-19) | 49-39 | |
| » Starters: Reggie Cleveland vs Jerry Reuss | Second | 5 out |
| Wednesday, July 19 |
| » Lost to Cardinals (44-40), 6-0 | Astrodome (21-20) | 49-40 | |
| » Starters: Rick Wise vs Larry Dierker | Second | 6 out |
| Friday, July 21 |
| » Lost to Cubs (46-42), 11-3 | Astrodome (21-21) | 49-41 | Lost 2 |
| » Starters: Bill Bonham vs Ken Forsch | Second | 7 out |
| Saturday, July 22 |
| » Defeated Cubs (46-43), 7-2 | Astrodome (22-21) | 50-41 | |
| » Starters: Rick Reuschel vs Don Wilson | Second | 7 out |
| Sunday, July 23 |
| » Defeated Cubs (46-44), 6-5 | Astrodome (23-21) | 51-41 | Won 2 |
| » Starters: Fergie Jenkins vs Dave Roberts | Second | 6 out |
| Thursday, July 27 |
| » Lost to Dodgers (48-42), 6-3 | Astrodome (23-22) | 51-42 | |
| » Starters: Claude Osteen vs Ken Forsch | Second | 7 out |
| Friday, July 28 |
| » Lost to Dodgers (49-42), 6-5 | Astrodome (23-23) | 51-43 | Lost 2 |
| » Starters: Al Downing vs Don Wilson | Second | 7 out |
| Saturday, July 29 |
| » Defeated Dodgers (49-43), 7-2 | Astrodome (24-23) | 52-43 | |
| » Starters: Don Sutton vs Jerry Reuss | Second | 6 out |
| Sunday, July 30 |
| » Lost to Padres (36-57), 10-7 | Astrodome (24-24) | 52-44 | |
| » Starters: Fred Norman vs J.R. Richard | Second | 6 out |
| » Defeated Padres (36-58), 4-3 | Astrodome (25-24) | 53-44 | |
| » Starters: Bill Greif vs Dave Roberts | Second | 6 out |
| Monday, July 31 |
| » Defeated Padres (36-59), 3-2 | Astrodome (26-24) | 54-44 | Won 2 |
| » Starters: Steve Arlin vs Larry Dierker | Second | 5 out |
| Tuesday, August 1 |
| » Lost to Reds (58-37), 3-1 | Astrodome (26-25) | 54-45 | |
| » Starters: Wayne Simpson vs Ken Forsch | Second | 6 out |
| Wednesday, August 2 |
| » Defeated Reds (58-38), 10-1 | Astrodome (27-25) | 55-45 | |
| » Starters: Gary Nolan vs Don Wilson | Second | 5 out |
| Friday, August 4 |
| » Defeated Giants (45-57), 6-1 | Candlestick Park (4-0) | 56-45 | Won 2 |
| » Starters: Jerry Reuss vs Juan Marichal | Second | 5½ out |
| Saturday, August 5 |
| » Defeated Giants (45-58), 4-3 | Candlestick Park (5-0) | 57-45 | Won 3 |
| » Starters: Dave Roberts vs Don Carrithers | Second | 5½ out |
| Sunday, August 6 |
| » Defeated Giants (45-59), 7-3 | Candlestick Park (6-0) | 58-45 | Won 4 |
| » Starters: Larry Dierker vs Jim Barr | Second | 5 out |
| » Lost to Giants (46-59), 6-2 | Candlestick Park (6-1) | 58-46 | |
| » Starters: Tom Griffin vs Jim Willoughby | Second | 5 out |
| Tuesday, August 8 |
| » Lost to Braves (48-58), 8-4 | Atlanta-Fulton County Stadium (0-1) | 58-47 | Lost 2 |
| » Starters: Don Wilson vs Denny McLain | Second | 6½ out |
| Wednesday, August 9 |
| » Lost to Braves (49-58), 6-0 | Atlanta-Fulton County Stadium (0-2) | 58-48 | Lost 3 |
| » Starters: Jerry Reuss vs George Stone | Second | 7½ out |
| Thursday, August 10 |
| » Defeated Braves (49-59), 9-6 | Atlanta-Fulton County Stadium (1-2) | 59-48 | |
| » Starters: Dave Roberts vs Ron Schueler | Second | 6½ out |
| Friday, August 11 |
| » Defeated Giants (48-61), 6-3 | Astrodome (28-25) | 60-48 | Won 2 |
| » Starters: Don Carrithers vs Larry Dierker | Second | 5½ out |
| Saturday, August 12 |
| » Defeated Giants (48-62), 3-1 | Astrodome (29-25) | 61-48 | Won 3 |
| » Starters: Jim Barr vs Don Wilson | Second | 4½ out |
| Sunday, August 13 |
| » Lost to Giants (49-62), 4-3 | Astrodome (29-26) | 61-49 | |
| » Starters: Jim Willoughby vs Jerry Reuss | Second | 5½ out |
| Monday, August 14 |
| » Defeated Giants (49-63), 7-5 | Astrodome (30-26) | 62-49 | |
| » Starters: Frank Reberger vs Dave Roberts | Second | 5½ out |
| Tuesday, August 15 |
| » Lost to Expos (50-58), 3-2 | Parc Jarry (2-2) | 62-50 | |
| » Starters: Larry Dierker vs Bill Stoneman | Second | 6½ out |
| Wednesday, August 16 |
| » Defeated Expos (50-59), 5-0 | Parc Jarry (3-2) | 63-50 | |
| » Starters: Don Wilson vs Mike Torrez | Second | 6½ out |
| Thursday, August 17 |
| » Defeated Expos (50-60), 17-5 | Parc Jarry (4-2) | 64-50 | Won 2 |
| » Starters: Jerry Reuss vs Balor Moore | Second | 5½ out |
| Friday, August 18 |
| » Defeated Phillies (42-70), 4-3 | Veteran's Stadium (2-2) | 65-50 | Won 3 |
| » Starters: Dave Roberts vs Bucky Brandon | Second | 5½ out |
| Saturday, August 19 |
| » Lost to Phillies (43-70), 4-0 | Veteran's Stadium (2-3) | 65-51 | |
| » Starters: Larry Dierker vs Wayne Twitchell | Second | 6½ out |
| Sunday, August 20 |
| » Defeated Phillies (43-71), 3-1 | Veteran's Stadium (3-3) | 66-51 | |
| » Starters: Don Wilson vs Ken Reynolds | Second | 6½ out |
| Monday, August 21 |
| » Lost to Mets (60-53), 4-2 | Shea Stadium (2-2) | 66-52 | |
| » Starters: Jerry Reuss vs Jon Matlack | Second | 7½ out |
| Tuesday, August 22 |
| » Lost to Mets (61-53), 4-2 | Shea Stadium (2-3) | 66-53 | Lost 2 |
| » Starters: Dave Roberts vs Tom Seaver | Second | 8½ out |
| Wednesday, August 23 |
| » Defeated Mets (61-54), 7-4 | Shea Stadium (3-3) | 67-53 | |
| » Starters: Larry Dierker vs Jerry Koosman | Second | 7½ out |
| Thursday, August 24 |
| Future Astro Mike Grzanich is born in Canton, IL. |
| Friday, August 25 |
| » Lost to Expos (55-63), 4-3 | Astrodome (30-27) | 67-54 | |
| » Starters: Bill Stoneman vs Don Wilson | Second | 9 out |
| Saturday, August 26 |
| » Defeated Expos (55-64), 6-5 | Astrodome (31-27) | 68-54 | |
| » Manager: Salty Parker |
| » Starters: Mike Torrez vs Jerry Reuss | Second | 8 out |
| Sunday, August 27 |
| » Defeated Expos (55-65), 8-2 | Astrodome (32-27) | 69-54 | Won 2 |
| » Manager: Leo Durocher |
| » Starters: Carl Morton vs Larry Dierker | Second | 8 out |
| Tuesday, August 29 |
| » Defeated Phillies (44-77), 2-1 | Astrodome (33-27) | 70-54 | Won 3 |
| » Starters: Bucky Brandon vs Don Wilson | Second | 7½ out |
| Wednesday, August 30 |
| » Defeated Phillies (44-78), 5-3 | Astrodome (34-27) | 71-54 | Won 4 |
| » Starters: Steve Carlton vs Jerry Reuss | Second | 7½ out |
| Thursday, August 31 |
| » Defeated Phillies (44-79), 5-1 | Astrodome (35-27) | 72-54 | Won 5 |
| » Starters: Wayne Twitchell vs Larry Dierker | Second | 7 out |
| Friday, September 1 |
| » Defeated Mets (63-59), 8-0 | Astrodome (36-27) | 73-54 | Won 6 |
| » Starters: Tom Seaver vs Dave Roberts | Second | 7 out |
| Saturday, September 2 |
| » Lost to Mets (64-59), 11-8 | Astrodome (36-28) | 73-55 | |
| » Starters: Brent Strom vs Don Wilson | Second | 7 out |
| Sunday, September 3 |
| » Lost to Mets (65-59), 2-1 | Astrodome (36-29) | 73-56 | Lost 2 |
| » Starters: Jim McAndrew vs Jerry Reuss | Second | 8 out |
| Monday, September 4 |
| » Lost to Braves (60-72), 6-5 | Astrodome (36-30) | 73-57 | Lost 3 |
| » Starters: Phil Niekro vs Larry Dierker | Second | 8½ out |
| Tuesday, September 5 |
| » Lost to Braves (61-72), 5-3 | Astrodome (36-31) | 73-58 | Lost 4 |
| » Starters: Pat Jarvis vs Dave Roberts | Second | 8½ out |
| Thursday, September 7 |
| » Defeated Giants (58-75), 5-1 | Candlestick Park (7-1) | 74-58 | |
| » Starters: Don Wilson vs Sam McDowell | Second | 7½ out |
| Friday, September 8 |
| » Defeated Giants (58-76), 5-3 | Candlestick Park (8-1) | 75-58 | Won 2 |
| » Starters: Larry Dierker vs Jim Barr | Second | 7 out |
| » Major-league debuts: Elias Sosa (Giants) |
| Saturday, September 9 |
| » Lost to Dodgers (72-62), 4-0 | Dodger Stadium (3-4) | 75-59 | |
| » Starters: Jerry Reuss vs Claude Osteen | Second | 7 out |
| Future Astro Mike Hampton is born in Brooksville, FL. |
| Sunday, September 10 |
| » Lost to Dodgers (73-62), 3-2 | Dodger Stadium (3-5) | 75-60 | Lost 2 |
| » Starters: Dave Roberts vs Don Sutton | Second | 7½ out |
| » Major-league debuts: Mike Cosgrove (Astros) |
| Monday, September 11 |
| » Defeated Dodgers (73-63), 4-3 | Dodger Stadium (4-5) | 76-60 | |
| » Starters: Don Wilson vs Al Downing | Second | 7 out |
| Tuesday, September 12 |
| » Major-league debuts: Terry McDermott (Dodgers) |
| Wednesday, September 13 |
| » Defeated Padres (51-84), 6-5 | Astrodome (37-31) | 77-60 | Won 2 |
| » Starters: Mike Caldwell vs Larry Dierker | Second | 7½ out |
| » Major-league debuts: Cliff Johnson (Astros) |
| Future Astro Nelson Cruz is born in Puerto Plata, D.R. |
| Thursday, September 14 |
| » Defeated Padres (51-85), 10-6 | Astrodome (38-31) | 78-60 | Won 3 |
| » Starters: Steve Arlin vs Jerry Reuss | Second | 7 out |
| Friday, September 15 |
| » Lost to Dodgers (74-65), 4-2 | Astrodome (38-32) | 78-61 | |
| » Starters: Claude Osteen vs Don Wilson | Second | 7 out |
| Saturday, September 16 |
| » Lost to Dodgers (75-65), 10-0 | Astrodome (38-33) | 78-62 | Lost 2 |
| » Starters: Don Sutton vs Ken Forsch | Second | 8 out |
| Sunday, September 17 |
| » Defeated Dodgers (75-66), 15-11 | Astrodome (39-33) | 79-62 | |
| » Starters: Al Downing vs Larry Dierker | Second | 7 out |
| Tuesday, September 19 |
| » Defeated Braves (66-77), 5-3 | Atlanta-Fulton County Stadium (2-2) | 80-62 | Won 2 |
| » Starters: Don Wilson vs Mike McQueen | Second | 7½ out |
| Wednesday, September 20 |
| » Lost to Braves (67-77), 13-6 | Atlanta-Fulton County Stadium (2-3) | 80-63 | |
| » Starters: Tom Griffin vs George Stone | Second | 8½ out |
| Friday, September 22 |
| » Lost to Reds (90-55), 4-3 | Astrodome (39-34) | 80-64 | Lost 2 |
| » Starters: Ross Grimsley vs Larry Dierker | Second | 9½ out |
| Saturday, September 23 |
| » Defeated Reds (90-56), 7-1 | Astrodome (40-34) | 81-64 | |
| » Starters: Jim McGlothlin vs Don Wilson | Second | 8½ out |
| Sunday, September 24 |
| » Lost to Reds (91-56), 10-2 | Astrodome (40-35) | 81-65 | |
| » Starters: Jack Billingham vs Ken Forsch | Second | 9½ out |
| Tuesday, September 26 |
| » Lost to Giants (64-85), 5-2 | Astrodome (40-36) | 81-66 | Lost 2 |
| » Starters: Sam McDowell vs Jerry Reuss | Second | 9½ out |
| Wednesday, September 27 |
| » Defeated Giants (64-86), 3-0 | Astrodome (41-36) | 82-66 | |
| » Starters: Jim Willoughby vs Don Wilson | Second | 8½ out |
| Friday, September 29 |
| » Defeated Padres (57-92), 5-2 | San Diego/Jack Murphy Stadium (7-0) | 83-66 | Won 2 |
| » Starters: Ken Forsch vs Clay Kirby | Second | 8½ out |
| Saturday, September 30 |
| » Defeated Padres (57-93), 6-5 | San Diego/Jack Murphy Stadium (8-0) | 84-66 | Won 3 |
| » Starters: Jerry Reuss vs Fred Norman | Second | 7½ out |
| Future Astro Jose Lima is born in Santiago, D.R. |
| Sunday, October 1 |
| » Lost to Padres (58-93), 3-1 | San Diego/Jack Murphy Stadium (8-1) | 84-67 | |
| » Starters: Don Wilson vs Steve Arlin | Second | 8½ out |
| Tuesday, October 3 |
| » Lost to Reds (94-59), 6-1 | Riverfront Stadium (4-3) | 84-68 | Lost 2 |
| » Starters: Ken Forsch vs Gary Nolan | Second | 9½ out |
| Wednesday, October 4 |
| » Lost to Reds (95-59), 4-2 | Riverfront Stadium (4-4) | 84-69 | Lost 3 |
| » Starters: Mike Cosgrove vs Pedro Borbon | Second | 10½ out |
Game information provided by Retrosheet (www.retrosheet.org) |
