| Thursday, January 7 |
| Former White Sox Hal Rhyne dies in Orangevale, CA at the age of 72. |
| Friday, March 5 |
| Future White Sox Chad Fonville is born in Jacksonville, NC. |
| Monday, March 29 |
| Future White Sox Sean Lowe is born in Dallas, TX. |
| Tuesday, April 6 |
| » Major-league debuts: Steve Braun and Ray Corbin (Twins) |
| Wednesday, April 7 |
| » Defeated Athletics (0-2), 6-5 | Oakland-Alameda County Stadium (1-0) | 1-0 | |
| » Starters: Tommy John vs Catfish Hunter | First | -- |
| » Defeated Athletics (0-3), 12-4 | Oakland-Alameda County Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Bart Johnson vs Rollie Fingers | First | -- |
| » Major-league debuts: Lee Richard (White Sox) |
| Friday, April 9 |
| » Defeated Twins (1-2), 3-2 | Comiskey Park I (1-0) | 3-0 | Won 3 |
| » Starters: Tom Hall vs Tom Bradley | First | -- |
| Saturday, April 10 |
| » Lost to Twins (2-2), 5-3 | Comiskey Park I (1-1) | 3-1 | |
| » Starters: Jim Perry vs Tommy John | First | -- |
| Sunday, April 11 |
| » Lost to Twins (3-2), 6-0 | Comiskey Park I (1-2) | 3-2 | Lost 2 |
| » Starters: Jim Kaat vs Bart Johnson | Second | ½ out |
| » Major-league debuts: Terry Forster (White Sox) |
| Monday, April 12 |
| » Lost to Angels (2-4), 3-2 | Comiskey Park I (1-3) | 3-3 | Lost 3 |
| » Starters: Rudy May vs Wilbur Wood | Third | 1 out |
| Tuesday, April 13 |
| » Lost to Angels (3-4), 3-1 | Comiskey Park I (1-4) | 3-4 | Lost 4 |
| » Starters: Andy Messersmith vs Tom Bradley | Fourth | 1 out |
| Wednesday, April 14 |
| » Lost to Brewers (4-3), 2-0 | Comiskey Park I (1-5) | 3-5 | Lost 5 |
| » Starters: Jim Slaton vs Tommy John | Fifth | 1½ out |
| » Major-league debuts: Jim Slaton (Brewers) |
| Thursday, April 15 |
| » Lost to Brewers (5-3), 4-1 | Comiskey Park I (1-6) | 3-6 | Lost 6 |
| » Starters: Skip Lockwood vs Bart Johnson | Sixth | 2½ out |
| Friday, April 16 |
| » Lost to Athletics (7-4), 5-4 | Comiskey Park I (1-7) | 3-7 | Lost 7 |
| » Starters: Rob Gardner vs Wilbur Wood | Fifth | 3½ out |
| Former White Sox Ron Northey dies in Pittsburgh, PA at the age of 51. |
| Saturday, April 17 |
| » Defeated Athletics (7-5), 4-0 | Comiskey Park I (2-7) | 4-7 | |
| » Starters: Rollie Fingers vs Tom Bradley | Fifth | 3 out |
| Sunday, April 18 |
| » Lost to Athletics (8-5), 11-2 | Comiskey Park I (2-8) | 4-8 | |
| » Starters: Vida Blue vs Tommy John | Sixth | 4½ out |
| » Lost to Athletics (9-5), 6-1 | Comiskey Park I (2-9) | 4-9 | Lost 2 |
| » Starters: Diego Segui vs Terry Forster | Sixth | 4½ out |
| Tuesday, April 20 |
| » Defeated Brewers (6-6), 7-1 | County Stadium (1-0) | 5-9 | |
| » Starters: Bart Johnson vs Skip Lockwood | Sixth | 4½ out |
| Thursday, April 22 |
| » Defeated Brewers (6-7), 4-2 | County Stadium (2-0) | 6-9 | Won 2 |
| » Starters: Tom Bradley vs Marty Pattin | Fifth | 5 out |
| Friday, April 23 |
| » Lost to Red Sox (8-6), 7-1 | Fenway Park (0-1) | 6-10 | |
| » Starters: Tommy John vs Sonny Siebert | Sixth | 6 out |
| Saturday, April 24 |
| » Lost to Red Sox (9-6), 4-2 | Fenway Park (0-2) | 6-11 | Lost 2 |
| » Starters: Bart Johnson vs Mike Nagy | Sixth | 7 out |
| Sunday, April 25 |
| » Lost to Red Sox (10-6), 5-4 | Fenway Park (0-3) | 6-12 | Lost 3 |
| » Starters: Wilbur Wood vs Gary Peters | Fifth | 7 out |
| Tuesday, April 27 |
| » Lost to Yankees (7-10), 6-5 | Yankee Stadium (0-1) | 6-13 | Lost 4 |
| » Starters: Tommy John vs Mel Stottlemyre | Sixth | 7½ out |
| Thursday, April 29 |
| » Defeated Senators (12-9), 5-4 | Robert F. Kennedy Stadium (1-0) | 7-13 | |
| » Starters: Tom Bradley vs Dick Bosman | Sixth | 7 out |
| Friday, April 30 |
| » Defeated Senators (12-10), 8-1 | Robert F. Kennedy Stadium (2-0) | 8-13 | Won 2 |
| » Starters: Bart Johnson vs Jerry Janeski | Sixth | 7 out |
| Saturday, May 1 |
| » Defeated Senators (12-11), 5-3 | Robert F. Kennedy Stadium (3-0) | 9-13 | Won 3 |
| » Starters: Tommy John vs Denny McLain | Sixth | 6 out |
| Sunday, May 2 |
| » Defeated Senators (12-12), 3-1 | Robert F. Kennedy Stadium (4-0) | 10-13 | Won 4 |
| » Starters: Wilbur Wood vs Casey Cox | Fourth | 5½ out |
| Tuesday, May 4 |
| » Lost to Red Sox (15-8), 4-3 | Comiskey Park I (2-10) | 10-14 | |
| » Starters: Mike Nagy vs Tom Bradley | Sixth | 5½ out |
| Thursday, May 6 |
| » Lost to Red Sox (16-8), 10-1 | Comiskey Park I (2-11) | 10-15 | Lost 2 |
| » Starters: Gary Peters vs Bart Johnson | Sixth | 6½ out |
| Friday, May 7 |
| » Lost to Yankees (11-14), 4-3 | Comiskey Park I (2-12) | 10-16 | Lost 3 |
| » Starters: Fritz Peterson vs Tommy John | Sixth | 7 out |
| Saturday, May 8 |
| » Lost to Yankees (12-14), 2-1 | Comiskey Park I (2-13) | 10-17 | Lost 4 |
| » Starters: Steve Kline vs Tom Bradley | Sixth | 7½ out |
| Sunday, May 9 |
| » Lost to Yankees (13-14), 6-1 | Comiskey Park I (2-14) | 10-18 | Lost 5 |
| » Starters: Mike Kekich vs Wilbur Wood | Sixth | 9 out |
| Wednesday, May 12 |
| » Defeated Senators (13-17), 5-0 | Comiskey Park I (3-14) | 11-18 | |
| » Starters: Dick Bosman vs Tom Bradley | Fifth | 8 out |
| » Defeated Senators (13-18), 9-5 | Comiskey Park I (4-14) | 12-18 | Won 2 |
| » Starters: Casey Cox vs Bart Johnson | Fifth | 8 out |
| Thursday, May 13 |
| Future White Sox Mike Sirotka is born in Houston, TX. |
| Friday, May 14 |
| » Lost to Twins (17-16), 4-3 | Metropolitan Stadium (0-1) | 12-19 | |
| » Starters: Wilbur Wood vs Jim Kaat | Sixth | 9½ out |
| Saturday, May 15 |
| » Defeated Twins (17-17), 8-2 | Metropolitan Stadium (1-1) | 13-19 | |
| » Starters: Bart Johnson vs Jim Perry | Sixth | 8½ out |
| Sunday, May 16 |
| » Lost to Twins (18-17), 6-2 | Metropolitan Stadium (1-2) | 13-20 | |
| » Starters: Tom Bradley vs Pete Hamm | Fifth | 9 out |
| Wednesday, May 19 |
| » Lost to Royals (19-19), 2-0 | Municipal Stadium (0-1) | 13-21 | Lost 2 |
| » Starters: Bart Johnson vs Mike Hedlund | Sixth | 10½ out |
| Friday, May 21 |
| » Defeated Angels (20-22), 3-0 | Anaheim Stadium (1-0) | 14-21 | |
| » Starters: Tom Bradley vs Rudy May | Fifth | 10 out |
| Saturday, May 22 |
| » Defeated Angels (20-23), 13-0 | Anaheim Stadium (2-0) | 15-21 | Won 2 |
| » Starters: Wilbur Wood vs Tom Murphy | Fifth | 10 out |
| Sunday, May 23 |
| » Lost to Angels (21-23), 10-5 | Anaheim Stadium (2-1) | 15-22 | |
| » Starters: Bart Johnson vs Andy Messersmith | Sixth | 11 out |
| Monday, May 24 |
| Future White Sox Todd Rizzo is born in Clifton Heights, PA. Former White Sox Tommy Thompson dies in Auburn, CA at the age of 62 |
| Tuesday, May 25 |
| » Lost to Royals (20-21), 8-3 | Comiskey Park I (4-15) | 15-23 | Lost 2 |
| » Starters: Dick Drago vs Tom Bradley | Sixth | 12 out |
| Wednesday, May 26 |
| » Defeated Royals (20-22), 7-2 | Comiskey Park I (5-15) | 16-23 | |
| » Starters: Mike Hedlund vs Wilbur Wood | Fifth | 11 out |
| Future White Sox Jason Bere is born in Cambridge, MA. |
| Friday, May 28 |
| » Lost to Indians (19-24), 4-0 | Comiskey Park I (5-16) | 16-24 | |
| » Starters: Sam McDowell vs Bart Johnson | Sixth | 11 out |
| » Major-league debuts: Chris Chambliss (Indians) |
| Saturday, May 29 |
| » Lost to Indians (20-24), 2-1 | Comiskey Park I (5-17) | 16-25 | Lost 2 |
| » Starters: Ray Lamb vs Tom Bradley | Sixth | 12 out |
| Sunday, May 30 |
| » Defeated Indians (20-25), 3-2 | Comiskey Park I (6-17) | 17-25 | |
| » Starters: Alan Foster vs Wilbur Wood | Sixth | 11½ out |
| Monday, May 31 |
| » Defeated Orioles (26-19), 1-0 | Comiskey Park I (7-17) | 18-25 | Won 2 |
| » Starters: Jim Palmer vs Tommy John | Sixth | 11½ out |
| » Lost to Orioles (27-19), 11-3 | Comiskey Park I (7-18) | 18-26 | |
| » Starters: Dave McNally vs Joe Horlen | Sixth | 11½ out |
| Wednesday, June 2 |
| » Lost to Orioles (28-19), 3-2 | Comiskey Park I (7-19) | 18-27 | Lost 2 |
| » Starters: Pat Dobson vs Tom Bradley | Sixth | 12½ out |
| Thursday, June 3 |
| Future White Sox Carl Everett is born in Tampa, FL. |
| Friday, June 4 |
| » Defeated Tigers (27-24), 3-2 | Comiskey Park I (8-19) | 19-27 | |
| » Starters: Mickey Lolich vs Wilbur Wood | Sixth | 12½ out |
| Saturday, June 5 |
| » Lost to Tigers (28-24), 7-3 | Comiskey Park I (8-20) | 19-28 | |
| » Starters: Les Cain vs Tommy John | Sixth | 13½ out |
| Sunday, June 6 |
| » Defeated Tigers (28-25), 8-2 | Comiskey Park I (9-20) | 20-28 | |
| » Starters: Joe Coleman vs Tom Bradley | Fifth | 13½ out |
| Tuesday, June 8 |
| » Lost to Indians (24-28), 5-3 | Cleveland Stadium (0-1) | 20-29 | |
| » Starters: Wilbur Wood vs Sam McDowell | Fifth | 13½ out |
| Wednesday, June 9 |
| » Lost to Indians (25-28), 3-1 | Cleveland Stadium (0-2) | 20-30 | Lost 2 |
| » Starters: Tommy John vs Alan Foster | Fifth | 14½ out |
| » Major-league debuts: Ed Farmer (Indians) |
| Thursday, June 10 |
| » Lost to Indians (26-28), 9-0 | Cleveland Stadium (0-3) | 20-31 | Lost 3 |
| » Starters: Tom Bradley vs Ray Lamb | Fifth | 15 out |
| Friday, June 11 |
| » Lost to Orioles (35-19), 8-5 | Memorial Stadium (0-1) | 20-32 | Lost 4 |
| » Starters: Joe Horlen vs Dave McNally | Fifth | 15 out |
| Saturday, June 12 |
| » Defeated Orioles (35-20), 7-3 | Memorial Stadium (1-1) | 21-32 | |
| » Starters: Wilbur Wood vs Pat Dobson | Fifth | 15 out |
| Sunday, June 13 |
| » Lost to Orioles (36-20), 2-1 | Memorial Stadium (1-2) | 21-33 | |
| » Starters: Tommy John vs Mike Cuellar | Fifth | 15 out |
| Monday, June 14 |
| » Lost to Tigers (34-26), 4-3 | Tiger Stadium (0-1) | 21-34 | Lost 2 |
| » Starters: Tom Bradley vs Joe Coleman | Fifth | 15½ out |
| Tuesday, June 15 |
| » Defeated Tigers (34-27), 6-1 | Tiger Stadium (1-1) | 22-34 | |
| » Starters: Joe Horlen vs Mike Kilkenny | Fifth | 15½ out |
| Wednesday, June 16 |
| » Lost to Tigers (35-27), 6-5 | Tiger Stadium (1-2) | 22-35 | |
| » Starters: Terry Forster vs Mickey Lolich | Fifth | 16½ out |
| Thursday, June 17 |
| » Lost to Twins (32-32), 7-6 | Metropolitan Stadium (1-3) | 22-36 | Lost 2 |
| » Starters: Tommy John vs Ray Corbin | Sixth | 17 out |
| Friday, June 18 |
| » Lost to Twins (33-32), 4-3 | Metropolitan Stadium (1-4) | 22-37 | Lost 3 |
| » Starters: Tom Bradley vs Jim Perry | Sixth | 18 out |
| Saturday, June 19 |
| » Lost to Twins (34-32), 2-1 | Metropolitan Stadium (1-5) | 22-38 | Lost 4 |
| » Starters: Wilbur Wood vs Bert Blyleven | Sixth | 19 out |
| Sunday, June 20 |
| » Defeated Twins (34-33), 18-8 | Metropolitan Stadium (2-5) | 23-38 | |
| » Starters: Joe Horlen vs Jim Kaat | Fifth | 18½ out |
| » Major-league debuts: Stan Perzanowski (White Sox) |
| Monday, June 21 |
| » Defeated Royals (35-28), 5-1 | Comiskey Park I (10-20) | 24-38 | Won 2 |
| » Starters: Jim Rooker vs Tommy John | Fifth | 18½ out |
| Tuesday, June 22 |
| » Defeated Royals (35-29), 11-6 | Comiskey Park I (11-20) | 25-38 | Won 3 |
| » Starters: Dick Drago vs Tom Bradley | Fifth | 17½ out |
| Wednesday, June 23 |
| » Defeated Royals (35-30), 12-3 | Comiskey Park I (12-20) | 26-38 | Won 4 |
| » Starters: Paul Splittorff vs Wilbur Wood | Fifth | 17½ out |
| Friday, June 25 |
| » Defeated Angels (32-42), 2-0 | Comiskey Park I (13-20) | 27-38 | Won 5 |
| » Starters: Tom Murphy vs Tommy John | Fifth | 17½ out |
| Saturday, June 26 |
| » Defeated Angels (32-43), 4-3 | Comiskey Park I (14-20) | 28-38 | Won 6 |
| » Starters: Rudy May vs Tom Bradley | Fifth | 17½ out |
| Sunday, June 27 |
| » Lost to Angels (33-43), 2-1 | Comiskey Park I (14-21) | 28-39 | |
| » Starters: Andy Messersmith vs Wilbur Wood | Sixth | 18½ out |
| » Lost to Angels (34-43), 12-3 | Comiskey Park I (14-22) | 28-40 | Lost 2 |
| » Starters: Rickey Clark vs Joe Horlen | Sixth | 18½ out |
| Monday, June 28 |
| » Lost to Brewers (30-40), 7-4 | County Stadium (2-1) | 28-41 | Lost 3 |
| » Starters: Vicente Romo vs Jim Hannan | Sixth | 19½ out |
| Tuesday, June 29 |
| » Lost to Brewers (31-40), 5-2 | County Stadium (2-2) | 28-42 | Lost 4 |
| » Starters: Tommy John vs Jim Slaton | Sixth | 19½ out |
| Wednesday, June 30 |
| » Defeated Brewers (31-41), 8-5 | County Stadium (3-2) | 29-42 | |
| » Starters: Tom Bradley vs Skip Lockwood | Sixth | 18 out |
| » Defeated Brewers (31-42), 8-3 | County Stadium (4-2) | 30-42 | Won 2 |
| » Starters: Wilbur Wood vs Marcelino Lopez | Sixth | 18 out |
| Thursday, July 1 |
| » Defeated Brewers (31-43), 6-4 | County Stadium (5-2) | 31-42 | Won 3 |
| » Starters: Joe Horlen vs Marty Pattin | Fifth | 17½ out |
| Friday, July 2 |
| » Defeated Royals (39-35), 2-1 | Municipal Stadium (1-1) | 32-42 | Won 4 |
| » Starters: Jim Magnuson vs Bill Butler | Fifth | 16½ out |
| Saturday, July 3 |
| » Defeated Royals (39-36), 1-0 | Municipal Stadium (2-1) | 33-42 | Won 5 |
| » Starters: Tommy John vs Paul Splittorff | Fourth | 16½ out |
| Sunday, July 4 |
| » Defeated Royals (39-37), 1-0 | Municipal Stadium (3-1) | 34-42 | Won 6 |
| » Starters: Wilbur Wood vs Mike Hedlund | Fourth | 16½ out |
| Monday, July 5 |
| » Lost to Royals (40-37), 6-1 | Municipal Stadium (3-2) | 34-43 | |
| » Starters: Tom Bradley vs Bruce DalCanton | Fourth | 17 out |
| » Lost to Royals (41-37), 1-0 | Municipal Stadium (3-3) | 34-44 | Lost 2 |
| » Starters: Joe Horlen vs Jim Rooker | Fourth | 17 out |
| Tuesday, July 6 |
| » Lost to Athletics (53-28), 9-4 | Comiskey Park I (14-23) | 34-45 | Lost 3 |
| » Starters: Diego Segui vs Jim Magnuson | Fifth | 18 out |
| Wednesday, July 7 |
| » Defeated Athletics (53-29), 2-1 | Comiskey Park I (15-23) | 35-45 | |
| » Starters: Blue Moon Odom vs Tommy John | Fifth | 17 out |
| Former White Sox Ray Phelps dies in Fort Pierce, FL at the age of 68. |
| Thursday, July 8 |
| » Lost to Athletics (54-29), 4-2 | Comiskey Park I (15-24) | 35-46 | |
| » Starters: Chuck Dobson vs Wilbur Wood | Sixth | 18 out |
| Friday, July 9 |
| » Defeated Brewers (36-46), 4-1 | Comiskey Park I (16-24) | 36-46 | |
| » Starters: Jim Slaton vs Joe Horlen | Fifth | 18 out |
| Saturday, July 10 |
| » Defeated Brewers (36-47), 4-3 | Comiskey Park I (17-24) | 37-46 | Won 2 |
| » Starters: Skip Lockwood vs Tom Bradley | Fifth | 17 out |
| Sunday, July 11 |
| » Lost to Brewers (37-47), 1-0 | Comiskey Park I (17-25) | 37-47 | |
| » Starters: Marty Pattin vs Tommy John | Fifth | 17 out |
| » Defeated Brewers (37-48), 1-0 | Comiskey Park I (18-25) | 38-47 | |
| » Starters: Bill Parsons vs Wilbur Wood | Fifth | 17 out |
| Thursday, July 15 |
| » Lost to Senators (35-52), 8-3 | Robert F. Kennedy Stadium (4-1) | 38-48 | |
| » Starters: Wilbur Wood vs Dick Bosman | Fifth | 18 out |
| Future White Sox James Baldwin is born in Southern Pines, NC. |
| Friday, July 16 |
| » Defeated Senators (35-53), 2-0 | Robert F. Kennedy Stadium (5-1) | 39-48 | |
| » Starters: Tommy John vs Pete Broberg | Fifth | 18 out |
| Saturday, July 17 |
| » Lost to Yankees (43-48), 4-2 | Yankee Stadium (0-2) | 39-49 | |
| » Starters: Joe Horlen vs Steve Kline | Fifth | 18 out |
| » Major-league debuts: Rich Hinton (White Sox) |
| Sunday, July 18 |
| » Lost to Yankees (44-48), 3-2 | Yankee Stadium (0-3) | 39-50 | Lost 2 |
| » Starters: Wilbur Wood vs Fritz Peterson | Fifth | 18½ out |
| » Lost to Yankees (45-48), 6-1 | Yankee Stadium (0-4) | 39-51 | Lost 3 |
| » Starters: Tom Bradley vs Mike Kekich | Fifth | 18½ out |
| » Major-league debuts: Ron Lolich (White Sox) |
| Monday, July 19 |
| » Defeated Yankees (45-49), 8-3 | Yankee Stadium (1-4) | 40-51 | |
| » Starters: Jim Magnuson vs Mel Stottlemyre | Fifth | 17 out |
| » Defeated Yankees (45-50), 3-1 | Yankee Stadium (2-4) | 41-51 | Won 2 |
| » Starters: Tommy John vs Jim Hardin | Fifth | 17 out |
| Tuesday, July 20 |
| » Lost to Red Sox (54-38), 5-4 | Fenway Park (0-4) | 41-52 | |
| » Starters: Steve Kealey vs Luis Tiant | Fifth | 18 out |
| Future White Sox Charles Johnson is born in Fort Pierce, FL. |
| Wednesday, July 21 |
| » Lost to Red Sox (55-38), 6-1 | Fenway Park (0-5) | 41-53 | Lost 2 |
| » Starters: Joe Horlen vs Sonny Siebert | Fifth | 19 out |
| Thursday, July 22 |
| » Defeated Red Sox (55-39), 4-2 | Fenway Park (1-5) | 42-53 | |
| » Starters: Wilbur Wood vs Jim Lonborg | Fifth | 18½ out |
| Saturday, July 24 |
| » Defeated Senators (39-56), 6-5 | Comiskey Park I (19-25) | 43-53 | Won 2 |
| » Starters: Bill Gogolewski vs Tommy John | Fourth | 19½ out |
| » Lost to Senators (40-56), 5-3 | Comiskey Park I (19-26) | 43-54 | |
| » Starters: Mike Thompson vs Tom Bradley | Fourth | 19½ out |
| Former White Sox Harry Suter dies in Topeka, KS at the age of 84. |
| Sunday, July 25 |
| » Defeated Senators (40-57), 5-1 | Comiskey Park I (20-26) | 44-54 | |
| » Starters: Dick Bosman vs Wilbur Wood | Fourth | 18½ out |
| » Defeated Senators (40-58), 9-6 | Comiskey Park I (21-26) | 45-54 | Won 2 |
| » Starters: Jackie Brown vs Joe Horlen | Fourth | 18½ out |
| Tuesday, July 27 |
| » Defeated Yankees (51-52), 9-6 | Comiskey Park I (22-26) | 46-54 | Won 3 |
| » Starters: Mel Stottlemyre vs Tommy John | Fourth | 17 out |
| Wednesday, July 28 |
| » Defeated Yankees (51-53), 5-4 | Comiskey Park I (23-26) | 47-54 | Won 4 |
| » Starters: Fritz Peterson vs Wilbur Wood | Fourth | 16 out |
| Former White Sox Myril Hoag dies in High Springs, FL at the age of 64. |
| Thursday, July 29 |
| » Defeated Yankees (51-54), 4-0 | Comiskey Park I (24-26) | 48-54 | Won 5 |
| » Starters: Mike Kekich vs Tom Bradley | Fourth | 15½ out |
| Friday, July 30 |
| » Defeated Red Sox (58-45), 5-1 | Comiskey Park I (25-26) | 49-54 | Won 6 |
| » Starters: Sonny Siebert vs Joe Horlen | Fourth | 14½ out |
| Saturday, July 31 |
| » Lost to Red Sox (59-45), 6-0 | Comiskey Park I (25-27) | 49-55 | |
| » Starters: Jim Lonborg vs Tommy John | Fourth | 15½ out |
| Sunday, August 1 |
| » Lost to Red Sox (60-45), 5-1 | Comiskey Park I (25-28) | 49-56 | Lost 2 |
| » Starters: Ray Culp vs Wilbur Wood | Fifth | 17½ out |
| » Lost to Red Sox (61-45), 6-1 | Comiskey Park I (25-29) | 49-57 | Lost 3 |
| » Starters: Gary Peters vs Vicente Romo | Fifth | 17½ out |
| Monday, August 2 |
| » Defeated Twins (48-57), 7-5 | Comiskey Park I (26-29) | 50-57 | |
| » Starters: Jim Perry vs Tom Bradley | Fourth | 17½ out |
| » Major-league debuts: Bob Gebhard (Twins) |
| Tuesday, August 3 |
| » Lost to Twins (49-57), 4-3 | Comiskey Park I (26-30) | 50-58 | |
| » Starters: Jim Kaat vs Joe Horlen | Fourth | 18½ out |
| Wednesday, August 4 |
| » Defeated Angels (53-59), 10-3 | Anaheim Stadium (3-1) | 51-58 | |
| » Starters: Tommy John vs Andy Messersmith | Fourth | 18½ out |
| Thursday, August 5 |
| » Defeated Angels (53-60), 1-0 | Anaheim Stadium (4-1) | 52-58 | Won 2 |
| » Starters: Wilbur Wood vs Clyde Wright | Third | 18½ out |
| Friday, August 6 |
| » Defeated Athletics (70-40), 7-0 | Oakland-Alameda County Stadium (3-0) | 53-58 | Won 3 |
| » Starters: Tom Bradley vs Blue Moon Odom | Third | 17½ out |
| Saturday, August 7 |
| » Lost to Athletics (71-40), 1-0 | Oakland-Alameda County Stadium (3-1) | 53-59 | |
| » Starters: Joe Horlen vs Vida Blue | Third | 18½ out |
| Sunday, August 8 |
| » Defeated Athletics (71-41), 9-7 | Oakland-Alameda County Stadium (4-1) | 54-59 | |
| » Starters: Tommy John vs Chuck Dobson | Third | 16½ out |
| » Defeated Athletics (71-42), 3-1 | Oakland-Alameda County Stadium (5-1) | 55-59 | Won 2 |
| » Starters: Wilbur Wood vs Diego Segui | Third | 16½ out |
| Tuesday, August 10 |
| » Lost to Indians (46-69), 4-1 | Comiskey Park I (26-31) | 55-60 | |
| » Starters: Sam McDowell vs Tom Bradley | Third | 18 out |
| Wednesday, August 11 |
| » Lost to Indians (47-69), 3-2 | Comiskey Park I (26-32) | 55-61 | Lost 2 |
| » Starters: Ray Lamb vs Joe Horlen | Third | 19 out |
| Thursday, August 12 |
| » Lost to Indians (48-69), 6-2 | Comiskey Park I (26-33) | 55-62 | Lost 3 |
| » Starters: Mike Paul vs Wilbur Wood | Third | 20 out |
| Friday, August 13 |
| » Lost to Orioles (71-42), 12-1 | Comiskey Park I (26-34) | 55-63 | Lost 4 |
| » Starters: Dave McNally vs Tommy John | Third | 21 out |
| Saturday, August 14 |
| » Defeated Orioles (71-43), 2-0 | Comiskey Park I (27-34) | 56-63 | |
| » Starters: Mike Cuellar vs Tom Bradley | Third | 21 out |
| Sunday, August 15 |
| » Defeated Orioles (71-44), 2-1 | Comiskey Park I (28-34) | 57-63 | Won 2 |
| » Starters: Pat Dobson vs Wilbur Wood | Third | 21 out |
| Tuesday, August 17 |
| » Defeated Tigers (65-55), 6-5 | Comiskey Park I (29-34) | 58-63 | Won 3 |
| » Starters: Mickey Lolich vs Tommy John | Third | 19½ out |
| » Defeated Tigers (65-56), 4-1 | Comiskey Park I (30-34) | 59-63 | Won 4 |
| » Starters: Les Cain vs Joe Horlen | Third | 19½ out |
| Wednesday, August 18 |
| » Defeated Tigers (65-57), 4-2 | Comiskey Park I (31-34) | 60-63 | Won 5 |
| » Starters: Joe Coleman vs Wilbur Wood | Third | 18½ out |
| Friday, August 20 |
| » Defeated Indians (49-75), 9-1 | Cleveland Stadium (1-3) | 61-63 | Won 6 |
| » Starters: Tom Bradley vs Vince Colbert | Third | 17½ out |
| Saturday, August 21 |
| » Lost to Indians (50-75), 9-4 | Cleveland Stadium (1-4) | 61-64 | |
| » Starters: Tommy John vs Ray Lamb | Third | 18½ out |
| Sunday, August 22 |
| » Defeated Indians (50-76), 5-3 | Cleveland Stadium (2-4) | 62-64 | |
| » Starters: Wilbur Wood vs Steve Dunning | Third | 19 out |
| Tuesday, August 24 |
| » Lost to Orioles (77-45), 1-0 | Memorial Stadium (1-3) | 62-65 | |
| » Starters: Tom Bradley vs Mike Cuellar | Third | 19½ out |
| Wednesday, August 25 |
| » Lost to Orioles (78-45), 6-3 | Memorial Stadium (1-4) | 62-66 | Lost 2 |
| » Starters: Wilbur Wood vs Pat Dobson | Third | 19½ out |
| Thursday, August 26 |
| » Lost to Orioles (79-45), 8-7 | Memorial Stadium (1-5) | 62-67 | Lost 3 |
| » Starters: Joe Horlen vs Jim Palmer | Third | 20 out |
| Friday, August 27 |
| » Lost to Tigers (70-59), 4-2 | Tiger Stadium (1-3) | 62-68 | Lost 4 |
| » Starters: Rich Hinton vs Joe Coleman | Third | 21 out |
| Saturday, August 28 |
| » Lost to Tigers (71-59), 5-4 | Tiger Stadium (1-4) | 62-69 | Lost 5 |
| » Starters: Tom Bradley vs Les Cain | Third | 22 out |
| Sunday, August 29 |
| » Defeated Tigers (71-60), 6-2 | Tiger Stadium (2-4) | 63-69 | |
| » Starters: Wilbur Wood vs Mickey Lolich | Third | 22½ out |
| Tuesday, August 31 |
| » Lost to Twins (60-71), 4-3 | Metropolitan Stadium (2-6) | 63-70 | |
| » Starters: Tom Bradley vs Jim Kaat | Third | 23½ out |
| Wednesday, September 1 |
| » Defeated Twins (60-72), 2-0 | Metropolitan Stadium (3-6) | 64-70 | |
| » Starters: Wilbur Wood vs Bert Blyleven | Third | 23½ out |
| Friday, September 3 |
| » Lost to Royals (71-64), 3-1 | Comiskey Park I (31-35) | 64-71 | |
| » Starters: Dick Drago vs Tommy John | Third | 23½ out |
| » Lost to Royals (72-64), 8-6 | Comiskey Park I (31-36) | 64-72 | Lost 2 |
| » Starters: Lance Clemons vs Joe Horlen | Third | 23½ out |
| Saturday, September 4 |
| » Lost to Royals (73-64), 3-1 | Comiskey Park I (31-37) | 64-73 | Lost 3 |
| » Starters: Al Fitzmorris vs Tom Bradley | Third | 24½ out |
| Sunday, September 5 |
| » Defeated Royals (73-65), 8-0 | Comiskey Park I (32-37) | 65-73 | |
| » Starters: Paul Splittorff vs Wilbur Wood | Third | 23½ out |
| Monday, September 6 |
| » Defeated Twins (63-74), 6-3 | Comiskey Park I (33-37) | 66-73 | Won 2 |
| » Starters: Tom Hall vs Bart Johnson | Third | 23 out |
| » Lost to Twins (64-74), 10-3 | Comiskey Park I (33-38) | 66-74 | |
| » Starters: Pete Hamm vs Rich Hinton | Third | 23 out |
| Tuesday, September 7 |
| » Defeated Twins (64-75), 8-7 | Comiskey Park I (34-38) | 67-74 | |
| » Starters: Jim Perry vs Tommy John | Third | 22 out |
| Wednesday, September 8 |
| » Lost to Twins (65-75), 3-1 | Comiskey Park I (34-39) | 67-75 | |
| » Starters: Jim Kaat vs Wilbur Wood | Third | 23 out |
| Friday, September 10 |
| » Lost to Royals (77-66), 6-1 | Municipal Stadium (3-4) | 67-76 | Lost 2 |
| » Starters: Tom Bradley vs Paul Splittorff | Fourth | 24 out |
| Saturday, September 11 |
| » Lost to Royals (78-66), 4-2 | Municipal Stadium (3-5) | 67-77 | Lost 3 |
| » Starters: Tommy John vs Mike Hedlund | Fourth | 25 out |
| Sunday, September 12 |
| » Defeated Royals (78-67), 3-0 | Municipal Stadium (4-5) | 68-77 | |
| » Starters: Wilbur Wood vs Dick Drago | Third | 24 out |
| Monday, September 13 |
| » Defeated Brewers (63-83), 6-3 | County Stadium (6-2) | 69-77 | Won 2 |
| » Starters: Bart Johnson vs Jim Slaton | Third | 24 out |
| Tuesday, September 14 |
| » Lost to Brewers (64-83), 5-4 | County Stadium (6-3) | 69-78 | |
| » Starters: Tom Bradley vs Bill Parsons | Third | 24 out |
| Wednesday, September 15 |
| » Lost to Athletics (94-54), 3-2 | Comiskey Park I (34-40) | 69-79 | Lost 2 |
| » Starters: Chuck Dobson vs Wilbur Wood | Third | 24 out |
| » Defeated Athletics (94-55), 7-3 | Comiskey Park I (35-40) | 70-79 | |
| » Starters: Blue Moon Odom vs Tommy John | Third | 24 out |
| Friday, September 17 |
| » Defeated Angels (71-80), 9-4 | Comiskey Park I (36-40) | 71-79 | Won 2 |
| » Starters: Rudy May vs Bart Johnson | Third | 24 out |
| Saturday, September 18 |
| » Defeated Angels (71-81), 5-1 | Comiskey Park I (37-40) | 72-79 | Won 3 |
| » Starters: Tom Murphy vs Tom Bradley | Third | 24 out |
| Sunday, September 19 |
| » Lost to Angels (72-81), 2-0 | Comiskey Park I (37-41) | 72-80 | |
| » Starters: Andy Messersmith vs Wilbur Wood | Third | 25 out |
| Monday, September 20 |
| » Major-league debuts: Rusty Torres (Yankees) |
| Tuesday, September 21 |
| » Defeated Athletics (97-56), 5-1 | Oakland-Alameda County Stadium (6-1) | 73-80 | |
| » Starters: Bart Johnson vs Chuck Dobson | Third | 23 out |
| » Defeated Athletics (97-57), 6-2 | Oakland-Alameda County Stadium (7-1) | 74-80 | Won 2 |
| » Starters: Tommy John vs Blue Moon Odom | Third | 23 out |
|
