| Thursday, January 7 |
| Former Red Sox Hal Rhyne dies in Orangevale, CA at the age of 72. |
| Monday, January 11 |
| Future Red Sox Alex Delgado is born in Palmerejo, Venezuela. |
| Sunday, January 24 |
| Future Red Sox Cory Bailey is born in Marion, IL. |
| Sunday, January 31 |
| Former Red Sox Steve Yerkes dies in Lansdale, PA at the age of 83. |
| Tuesday, February 16 |
| Former Red Sox Cedric Durst dies in San Diego, CA at the age of 75. |
| Friday, March 5 |
| Future Red Sox Chad Fonville is born in Jacksonville, NC. |
| Thursday, March 11 |
| Future Red Sox Sang-Hoon Lee is born in Seoul, South Korea. |
| Thursday, March 18 |
| Former Red Sox Tony Welzer dies in Milwaukee, WI at the age of 72. |
| Saturday, March 20 |
| Future Red Sox Manny Alexander is born in San Pedro de Macoris, D.R. |
| Friday, March 26 |
| Future Red Sox Jesus Tavarez is born in Santo Domingo, D.R. |
| Sunday, April 4 |
| Former Red Sox Carl Mays dies in ElCajon, CA at the age of 80. |
| Tuesday, April 6 |
| » Defeated Yankees (0-1), 3-1 | Fenway Park (1-0) | 1-0 | |
| » Starters: Stan Bahnsen vs Ray Culp | First | -- |
| Future Red Sox Lou Merloni is born in Framingham, MA. |
| Wednesday, April 7 |
| » Major-league debuts: Chris Speier (Giants) |
| Thursday, April 8 |
| » Lost to Indians (1-1), 3-2 | Cleveland Stadium (0-1) | 1-1 | |
| » Starters: Sonny Siebert vs Sam McDowell | Second | ½ out |
| Saturday, April 10 |
| » Lost to Indians (2-1), 11-10 | Cleveland Stadium (0-2) | 1-2 | Lost 2 |
| » Starters: Cal Koonce vs Steve Hargan | Fourth | 2 out |
| Sunday, April 11 |
| » Lost to Indians (3-1), 7-2 | Cleveland Stadium (0-3) | 1-3 | Lost 3 |
| » Starters: Gary Peters vs Alan Foster | Fifth | 2½ out |
| Monday, April 12 |
| » Defeated Senators (3-4), 10-7 | Robert F. Kennedy Stadium (1-0) | 2-3 | |
| » Starters: Ray Culp vs Jerry Janeski | Fourth | 2 out |
| Tuesday, April 13 |
| » Defeated Senators (3-5), 5-3 | Robert F. Kennedy Stadium (2-0) | 3-3 | Won 2 |
| » Starters: Sonny Siebert vs Denny McLain | Third | 1½ out |
| Wednesday, April 14 |
| » Lost to Senators (4-5), 6-5 | Robert F. Kennedy Stadium (2-1) | 3-4 | |
| » Starters: Mike Nagy vs Jim Shellenback | Fifth | 2½ out |
| Thursday, April 15 |
| Former Red Sox Mickey Harris dies in Farmington, MI at the age of 55. |
| Friday, April 16 |
| » Defeated Tigers (3-6), 5-3 | Tiger Stadium (1-0) | 4-4 | |
| » Starters: Gary Peters vs Joe Niekro | Third | 3 out |
| Saturday, April 17 |
| » Lost to Tigers (4-6), 10-9 | Tiger Stadium (1-1) | 4-5 | |
| » Starters: Ray Culp vs Mickey Lolich | Third | 3 out |
| Sunday, April 18 |
| » Defeated Tigers (4-7), 1-0 | Tiger Stadium (2-1) | 5-5 | |
| » Starters: Sonny Siebert vs Dean Chance | Second | 3 out |
| Monday, April 19 |
| » Lost to Indians (5-5), 5-4 | Fenway Park (1-1) | 5-6 | |
| » Starters: Alan Foster vs Mike Nagy | Fourth | 3½ out |
| Tuesday, April 20 |
| » Defeated Indians (5-6), 4-1 | Fenway Park (2-1) | 6-6 | |
| » Starters: Camilo Pascual vs Gary Peters | Third | 2½ out |
| Wednesday, April 21 |
| » Defeated Indians (5-7), 9-7 | Fenway Park (3-1) | 7-6 | Won 2 |
| » Starters: Steve Hargan vs Ray Culp | Third | 1½ out |
| Friday, April 23 |
| » Defeated White Sox (6-10), 7-1 | Fenway Park (4-1) | 8-6 | Won 3 |
| » Starters: Tommy John vs Sonny Siebert | Second | 1½ out |
| Saturday, April 24 |
| » Defeated White Sox (6-11), 4-2 | Fenway Park (5-1) | 9-6 | Won 4 |
| » Starters: Bart Johnson vs Mike Nagy | Second | ½ out |
| Sunday, April 25 |
| » Defeated White Sox (6-12), 5-4 | Fenway Park (6-1) | 10-6 | Won 5 |
| » Starters: Wilbur Wood vs Gary Peters | Second | ½ out |
| Tuesday, April 27 |
| » Lost to Brewers (8-9), 4-2 | Fenway Park (6-2) | 10-7 | |
| » Starters: Marty Pattin vs Ray Culp | Second | 1 out |
| Wednesday, April 28 |
| » Defeated Brewers (8-10), 10-3 | Fenway Park (7-2) | 11-7 | |
| » Starters: Bill Parsons vs Sonny Siebert | First | -- |
| Friday, April 30 |
| » Defeated Twins (9-12), 4-3 | Fenway Park (8-2) | 12-7 | Won 2 |
| » Starters: Jim Kaat vs Mike Nagy | First | -- |
| Saturday, May 1 |
| » Lost to Twins (10-12), 7-3 | Fenway Park (8-3) | 12-8 | |
| » Starters: Jim Perry vs Gary Peters | First | -- |
| Sunday, May 2 |
| » Defeated Twins (10-13), 1-0 | Fenway Park (9-3) | 13-8 | |
| » Starters: Bert Blyleven vs Ray Culp | First | -- |
| » Defeated Twins (10-14), 9-8 | Fenway Park (10-3) | 14-8 | Won 2 |
| » Starters: Steve Barber vs Sonny Siebert | First | -- |
| Tuesday, May 4 |
| » Defeated White Sox (10-14), 4-3 | Comiskey Park I (1-0) | 15-8 | Won 3 |
| » Starters: Mike Nagy vs Tom Bradley | First | -- |
| Thursday, May 6 |
| » Defeated White Sox (10-15), 10-1 | Comiskey Park I (2-0) | 16-8 | Won 4 |
| » Starters: Gary Peters vs Bart Johnson | First | -- |
| Future Red Sox Izzy Alcantara is born in Santo Domingo, D.R. |
| Friday, May 7 |
| » Defeated Brewers (11-14), 5-4 | County Stadium (1-0) | 17-8 | Won 5 |
| » Starters: Ray Culp vs Marty Pattin | First | -- |
| Saturday, May 8 |
| » Defeated Brewers (11-15), 4-2 | County Stadium (2-0) | 18-8 | Won 6 |
| » Starters: Sonny Siebert vs Lew Krausse | First | -- |
| Sunday, May 9 |
| » Lost to Brewers (12-15), 6-1 | County Stadium (2-1) | 18-9 | |
| » Starters: Mike Nagy vs Bill Parsons | First | -- |
| Tuesday, May 11 |
| » Defeated Twins (15-16), 5-4 | Metropolitan Stadium (1-0) | 19-9 | |
| » Starters: Gary Peters vs Tom Hall | First | -- |
| Wednesday, May 12 |
| » Lost to Twins (16-16), 1-0 | Metropolitan Stadium (1-1) | 19-10 | |
| » Starters: Ray Culp vs Bert Blyleven | First | -- |
| Former Red Sox Heinie Manush dies in Sarasota, FL at the age of 70. |
| Friday, May 14 |
| » Defeated Orioles (18-13), 2-0 | Fenway Park (11-3) | 20-10 | |
| » Starters: Jim Palmer vs Sonny Siebert | First | -- |
| Saturday, May 15 |
| » Lost to Orioles (19-13), 7-4 | Fenway Park (11-4) | 20-11 | |
| » Starters: Dave McNally vs Mike Nagy | First | -- |
| Monday, May 17 |
| » Defeated Tigers (16-18), 3-2 | Fenway Park (12-4) | 21-11 | |
| » Starters: Dean Chance vs Ray Culp | First | -- |
| Tuesday, May 18 |
| » Defeated Tigers (16-19), 5-3 | Fenway Park (13-4) | 22-11 | Won 2 |
| » Starters: Bill Zepp vs Gary Peters | First | -- |
| Future Red Sox Rich Garces is born in Maracay, Venezuela. |
| Wednesday, May 19 |
| » Defeated Yankees (16-18), 7-2 | Fenway Park (14-4) | 23-11 | Won 3 |
| » Starters: Steve Kline vs Sonny Siebert | First | -- |
| Thursday, May 20 |
| » Defeated Yankees (16-19), 5-2 | Fenway Park (15-4) | 24-11 | Won 4 |
| » Starters: Stan Bahnsen vs Bill Lee | First | -- |
| Friday, May 21 |
| » Defeated Orioles (21-15), 8-4 | Memorial Stadium (1-0) | 25-11 | Won 5 |
| » Starters: Jim Lonborg vs Pat Dobson | First | -- |
| Saturday, May 22 |
| » Lost to Orioles (22-15), 5-2 | Memorial Stadium (1-1) | 25-12 | |
| » Starters: Ray Culp vs Mike Cuellar | First | -- |
| Sunday, May 23 |
| » Lost to Orioles (23-15), 12-3 | Memorial Stadium (1-2) | 25-13 | Lost 2 |
| » Starters: Gary Peters vs Jim Palmer | First | -- |
| » Defeated Orioles (23-16), 2-1 | Memorial Stadium (2-2) | 26-13 | |
| » Starters: Sonny Siebert vs Dave McNally | First | -- |
| Monday, May 24 |
| » Lost to Senators (16-26), 8-6 | Fenway Park (15-5) | 26-14 | |
| » Starters: Casey Cox vs Bill Lee | First | -- |
| Tuesday, May 25 |
| » Lost to Senators (17-26), 6-5 | Fenway Park (15-6) | 26-15 | Lost 2 |
| » Starters: Bill Gogolewski vs Jim Lonborg | First | -- |
| Wednesday, May 26 |
| » Defeated Senators (17-27), 3-2 | Fenway Park (16-6) | 27-15 | |
| » Starters: Jerry Janeski vs Ray Culp | First | -- |
| Thursday, May 27 |
| » Defeated Senators (17-28), 6-2 | Fenway Park (17-6) | 28-15 | Won 2 |
| » Starters: Dick Bosman vs Gary Peters | First | -- |
| Friday, May 28 |
| » Defeated Athletics (31-17), 4-3 | Fenway Park (18-6) | 29-15 | Won 3 |
| » Starters: Vida Blue vs Sonny Siebert | First | -- |
| Saturday, May 29 |
| » Lost to Athletics (32-17), 12-8 | Fenway Park (18-7) | 29-16 | |
| » Starters: Chuck Dobson vs Jim Lonborg | First | -- |
| Monday, May 31 |
| » Lost to Royals (22-22), 7-3 | Fenway Park (18-8) | 29-17 | Lost 2 |
| » Starters: Bruce DalCanton vs Ray Culp | First | -- |
| » Lost to Royals (23-22), 9-4 | Fenway Park (18-9) | 29-18 | Lost 3 |
| » Starters: Dick Drago vs Gary Peters | First | -- |
| Future Red Sox Jose Malave is born in Cumana, Venezuela. |
| Tuesday, June 1 |
| » Lost to Royals (24-22), 4-2 | Fenway Park (18-10) | 29-19 | Lost 4 |
| » Starters: Mike Hedlund vs Jim Lonborg | First | -- |
| Wednesday, June 2 |
| » Lost to Yankees (22-27), 6-1 | Yankee Stadium (0-1) | 29-20 | Lost 5 |
| » Starters: Sonny Siebert vs Stan Bahnsen | Second | 1 out |
| Thursday, June 3 |
| » Defeated Yankees (22-28), 3-2 | Yankee Stadium (1-1) | 30-20 | |
| » Starters: Ray Culp vs Mel Stottlemyre | First | -- |
| Future Red Sox Carl Everett is born in Tampa, FL. |
| Friday, June 4 |
| » Defeated Angels (24-29), 10-1 | Fenway Park (19-10) | 31-20 | Won 2 |
| » Starters: Andy Messersmith vs Gary Peters | First | -- |
| Saturday, June 5 |
| » Lost to Angels (25-29), 3-2 | Fenway Park (19-11) | 31-21 | |
| » Starters: Tom Murphy vs Jim Lonborg | Second | 1½ out |
| Sunday, June 6 |
| » Lost to Angels (26-29), 5-2 | Fenway Park (19-12) | 31-22 | Lost 2 |
| » Starters: Clyde Wright vs Sonny Siebert | Second | 1½ out |
| Tuesday, June 8 |
| » Defeated Athletics (37-19), 5-1 | Oakland-Alameda County Stadium (1-0) | 32-22 | |
| » Starters: Ray Culp vs Blue Moon Odom | Second | 1½ out |
| Wednesday, June 9 |
| » Lost to Athletics (38-19), 6-1 | Oakland-Alameda County Stadium (1-1) | 32-23 | |
| » Starters: Gary Peters vs Chuck Dobson | Second | 2½ out |
| Friday, June 11 |
| » Lost to Royals (29-23), 6-3 | Municipal Stadium (0-1) | 32-24 | Lost 2 |
| » Starters: Luis Tiant vs Bruce DalCanton | Second | 4 out |
| Saturday, June 12 |
| » Lost to Royals (30-23), 7-0 | Municipal Stadium (0-2) | 32-25 | Lost 3 |
| » Starters: Jim Lonborg vs Dick Drago | Second | 4 out |
| Sunday, June 13 |
| » Lost to Royals (31-23), 4-3 | Municipal Stadium (0-3) | 32-26 | Lost 4 |
| » Starters: Sonny Siebert vs Paul Splittorff | Third | 5 out |
| Monday, June 14 |
| » Defeated Angels (28-34), 4-3 | Anaheim Stadium (1-0) | 33-26 | |
| » Starters: Ray Culp vs Andy Messersmith | Third | 4½ out |
| Tuesday, June 15 |
| » Lost to Angels (29-34), 5-4 | Anaheim Stadium (1-1) | 33-27 | |
| » Starters: Gary Peters vs Tom Murphy | Third | 4½ out |
| Wednesday, June 16 |
| » Defeated Angels (29-35), 4-1 | Anaheim Stadium (2-1) | 34-27 | |
| » Starters: Jim Lonborg vs Clyde Wright | Third | 4½ out |
| Thursday, June 17 |
| » Major-league debuts: Burt Hooton (Cubs) |
| Friday, June 18 |
| » Lost to Senators (22-38), 8-5 | Robert F. Kennedy Stadium (2-2) | 34-28 | |
| » Starters: Sonny Siebert vs Dick Bosman | Third | 6 out |
| Saturday, June 19 |
| » Lost to Senators (23-38), 2-0 | Robert F. Kennedy Stadium (2-3) | 34-29 | Lost 2 |
| » Starters: Ray Culp vs Jackie Brown | Third | 6 out |
| Sunday, June 20 |
| » Defeated Senators (23-39), 4-3 | Robert F. Kennedy Stadium (3-3) | 35-29 | |
| » Starters: Gary Peters vs Pete Broberg | Third | 6 out |
| » Major-league debuts: Pete Broberg (Senators) |
| Tuesday, June 22 |
| » Lost to Indians (31-34), 9-3 | Fenway Park (19-13) | 35-30 | |
| » Starters: Steve Hargan vs Bill Lee | Third | 6½ out |
| » Defeated Indians (31-35), 2-0 | Fenway Park (20-13) | 36-30 | |
| » Starters: Rich Hand vs Sonny Siebert | Third | 6½ out |
| » Major-league debuts: Kurt Bevacqua (Indians) |
| Wednesday, June 23 |
| » Defeated Indians (31-36), 2-1 | Fenway Park (21-13) | 37-30 | Won 2 |
| » Starters: Sam McDowell vs Ray Culp | Second | 6½ out |
| Friday, June 25 |
| » Lost to Orioles (45-23), 7-3 | Fenway Park (21-14) | 37-31 | |
| » Starters: Pat Dobson vs Jim Lonborg | Third | 8 out |
| Saturday, June 26 |
| » Defeated Orioles (45-24), 3-2 | Fenway Park (22-14) | 38-31 | |
| » Starters: Mike Cuellar vs Gary Peters | Third | 6 out |
| » Defeated Orioles (45-25), 10-2 | Fenway Park (23-14) | 39-31 | Won 2 |
| » Starters: Grant Jackson vs Sonny Siebert | Third | 6 out |
| Future Red Sox Greg Blosser is born in Manatee, FL. |
| Sunday, June 27 |
| » Defeated Orioles (45-26), 3-1 | Fenway Park (24-14) | 40-31 | Won 3 |
| » Starters: Jim Palmer vs Ray Culp | Second | 5 out |
| Monday, June 28 |
| » Defeated Senators (26-46), 10-4 | Fenway Park (25-14) | 41-31 | Won 4 |
| » Starters: Jackie Brown vs Luis Tiant | Second | 4 out |
| Future Red Sox Ron Mahay is born in Crestwood, IL. |
| Tuesday, June 29 |
| » Defeated Senators (26-47), 6-2 | Fenway Park (26-14) | 42-31 | Won 5 |
| » Starters: Pete Broberg vs Jim Lonborg | Second | 4 out |
| Wednesday, June 30 |
| » Defeated Tigers (42-34), 6-4 | Tiger Stadium (3-1) | 43-31 | Won 6 |
| » Starters: Gary Peters vs Joe Coleman | Second | 3½ out |
| Thursday, July 1 |
| » Defeated Tigers (42-35), 8-7 | Tiger Stadium (4-1) | 44-31 | Won 7 |
| » Starters: Sonny Siebert vs Bill Gilbreth | Second | 2½ out |
| » Major-league debuts: Buddy Hunter (Red Sox) |
| Former Red Sox Walt Kinney dies in Escondido, CA at the age of 78. |
| Friday, July 2 |
| » Lost to Yankees (36-43), 6-0 | Fenway Park (26-15) | 44-32 | |
| » Starters: Stan Bahnsen vs Ray Culp | Second | 2½ out |
| Saturday, July 3 |
| » Lost to Yankees (37-43), 2-1 | Fenway Park (26-16) | 44-33 | Lost 2 |
| » Starters: Fritz Peterson vs Luis Tiant | Second | 3½ out |
| Sunday, July 4 |
| » Defeated Yankees (37-44), 7-4 | Fenway Park (27-16) | 45-33 | |
| » Starters: Steve Kline vs Jim Lonborg | Second | 3½ out |
| Monday, July 5 |
| » Defeated Yankees (37-45), 12-7 | Fenway Park (28-16) | 46-33 | Won 2 |
| » Starters: Mel Stottlemyre vs Gary Peters | Second | 3 out |
| Tuesday, July 6 |
| » Defeated Indians (36-46), 3-2 | Cleveland Stadium (1-3) | 47-33 | Won 3 |
| » Starters: Sonny Siebert vs Ray Lamb | Second | 2½ out |
| Wednesday, July 7 |
| » Defeated Indians (36-47), 4-0 | Cleveland Stadium (2-3) | 48-33 | Won 4 |
| » Starters: Ray Culp vs Alan Foster | Second | 3 out |
| » Lost to Indians (37-47), 4-3 | Cleveland Stadium (2-4) | 48-34 | |
| » Starters: Luis Tiant vs Rich Hand | Second | 3 out |
| Thursday, July 8 |
| » Defeated Indians (37-48), 5-3 | Cleveland Stadium (3-4) | 49-34 | |
| » Starters: Jim Lonborg vs Steve Hargan | Second | 3 out |
| Friday, July 9 |
| » Lost to Yankees (39-47), 5-2 | Yankee Stadium (1-2) | 49-35 | |
| » Starters: Gary Peters vs Mel Stottlemyre | Second | 4 out |
| Saturday, July 10 |
| » Lost to Yankees (40-47), 5-3 | Yankee Stadium (1-3) | 49-36 | Lost 2 |
| » Starters: Sonny Siebert vs Stan Bahnsen | Second | 4½ out |
| Sunday, July 11 |
| » Lost to Yankees (41-47), 3-2 | Yankee Stadium (1-4) | 49-37 | Lost 3 |
| » Starters: Ray Culp vs Fritz Peterson | Second | 5½ out |
| Thursday, July 15 |
| » Defeated Twins (41-47), 3-0 | Fenway Park (29-16) | 50-37 | |
| » Starters: Jim Perry vs Luis Tiant | Second | 5½ out |
| Future Red Sox Tim Harikkala is born in West Palm Beach, FL. |
| Friday, July 16 |
| » Defeated Twins (41-48), 9-4 | Fenway Park (30-16) | 51-37 | Won 2 |
| » Starters: Bert Blyleven vs Sonny Siebert | Second | 4½ out |
| Saturday, July 17 |
| » Defeated Brewers (38-50), 13-11 | Fenway Park (31-16) | 52-37 | Won 3 |
| » Starters: Skip Lockwood vs Jim Lonborg | Second | 3 out |
| » Defeated Brewers (38-51), 5-3 | Fenway Park (32-16) | 53-37 | Won 4 |
| » Starters: Bill Parsons vs Ray Culp | Second | 3 out |
| Sunday, July 18 |
| » Lost to Brewers (39-51), 5-4 | Fenway Park (32-17) | 53-38 | |
| » Starters: Jim Slaton vs Gary Peters | Second | 4 out |
| Monday, July 19 |
| Future Red Sox Keith Johns is born in Jacksonville, FL. |
| Tuesday, July 20 |
| » Defeated White Sox (41-52), 5-4 | Fenway Park (33-17) | 54-38 | |
| » Starters: Steve Kealey vs Luis Tiant | Second | 3½ out |
| Wednesday, July 21 |
| » Defeated White Sox (41-53), 6-1 | Fenway Park (34-17) | 55-38 | Won 2 |
| » Starters: Joe Horlen vs Sonny Siebert | Second | 2½ out |
| Thursday, July 22 |
| » Lost to White Sox (42-53), 4-2 | Fenway Park (34-18) | 55-39 | |
| » Starters: Wilbur Wood vs Jim Lonborg | Second | 3½ out |
| Friday, July 23 |
| » Defeated Twins (43-53), 8-6 | Metropolitan Stadium (2-1) | 56-39 | |
| » Starters: Ray Culp vs Steve Luebber | Second | 3½ out |
| Saturday, July 24 |
| » Defeated Twins (43-54), 6-3 | Metropolitan Stadium (3-1) | 57-39 | Won 2 |
| » Starters: Gary Peters vs Jim Perry | Second | 3 out |
| Sunday, July 25 |
| » Lost to Twins (44-54), 6-2 | Metropolitan Stadium (3-2) | 57-40 | |
| » Starters: Luis Tiant vs Bert Blyleven | Second | 2½ out |
| Monday, July 26 |
| » Lost to Twins (45-54), 2-1 | Metropolitan Stadium (3-3) | 57-41 | Lost 2 |
| » Starters: Sonny Siebert vs Jim Kaat | Second | 3 out |
| Tuesday, July 27 |
| » Defeated Brewers (40-58), 4-3 | County Stadium (3-1) | 58-41 | |
| » Starters: Jim Lonborg vs Skip Lockwood | Second | 4 out |
| » Lost to Brewers (41-58), 5-1 | County Stadium (3-2) | 58-42 | |
| » Starters: Ray Culp vs Bill Parsons | Second | 4 out |
| Wednesday, July 28 |
| » Lost to Brewers (42-58), 5-0 | County Stadium (3-3) | 58-43 | Lost 2 |
| » Starters: Gary Peters vs Jim Slaton | Second | 5 out |
| Thursday, July 29 |
| » Lost to Brewers (43-58), 3-0 | County Stadium (3-4) | 58-44 | Lost 3 |
| » Starters: Luis Tiant vs Marty Pattin | Second | 5½ out |
| Friday, July 30 |
| » Lost to White Sox (49-54), 5-1 | Comiskey Park I (2-1) | 58-45 | Lost 4 |
| » Starters: Sonny Siebert vs Joe Horlen | Second | 6½ out |
| Saturday, July 31 |
| » Defeated White Sox (49-55), 6-0 | Comiskey Park I (3-1) | 59-45 | |
| » Starters: Jim Lonborg vs Tommy John | Second | 6½ out |
| Sunday, August 1 |
| » Defeated White Sox (49-56), 5-1 | Comiskey Park I (4-1) | 60-45 | Won 2 |
| » Starters: Ray Culp vs Wilbur Wood | Second | 5½ out |
| » Defeated White Sox (49-57), 6-1 | Comiskey Park I (5-1) | 61-45 | Won 3 |
| » Starters: Gary Peters vs Vicente Romo | Second | 5½ out |
| Monday, August 2 |
| » Defeated Orioles (65-39), 7-4 | Memorial Stadium (3-2) | 62-45 | Won 4 |
| » Starters: Luis Tiant vs Dave Leonhard | Second | 4½ out |
| Wednesday, August 4 |
| » Lost to Orioles (66-39), 5-4 | Memorial Stadium (3-3) | 62-46 | |
| » Starters: Jim Lonborg vs Jim Palmer | Second | 5½ out |
| Thursday, August 5 |
| » Defeated Tigers (58-51), 5-4 | Fenway Park (35-18) | 63-46 | |
| » Starters: Les Cain vs Gary Peters | Second | 4½ out |
| Friday, August 6 |
| » Lost to Tigers (59-51), 2-0 | Fenway Park (35-19) | 63-47 | |
| » Starters: Joe Coleman vs Ray Culp | Second | 4½ out |
| Saturday, August 7 |
| » Lost to Tigers (60-51), 12-8 | Fenway Park (35-20) | 63-48 | Lost 2 |
| » Starters: Joe Niekro vs Sonny Siebert | Second | 5½ out |
| Sunday, August 8 |
| » Lost to Tigers (61-51), 8-2 | Fenway Park (35-21) | 63-49 | Lost 3 |
| » Starters: Mickey Lolich vs Luis Tiant | Second | 5½ out |
| Monday, August 9 |
| » Defeated Tigers (61-52), 12-11 | Fenway Park (36-21) | 64-49 | |
| » Starters: Les Cain vs Jim Lonborg | Second | 5 out |
| Tuesday, August 10 |
| » Lost to Athletics (72-42), 6-5 | Fenway Park (36-22) | 64-50 | |
| » Starters: Catfish Hunter vs Gary Peters | Second | 6½ out |
| » Lost to Athletics (73-42), 7-5 | Fenway Park (36-23) | 64-51 | Lost 2 |
| » Starters: Blue Moon Odom vs Ray Culp | Second | 6½ out |
| Wednesday, August 11 |
| » Lost to Athletics (74-42), 5-3 | Fenway Park (36-24) | 64-52 | Lost 3 |
| » Starters: Vida Blue vs Sonny Siebert | Second | 7½ out |
| Thursday, August 12 |
| » Lost to Athletics (75-42), 9-2 | Fenway Park (36-25) | 64-53 | Lost 4 |
| » Starters: Diego Segui vs Ken Brett | Third | 8½ out |
| Friday, August 13 |
| » Lost to Royals (61-55), 5-1 | Fenway Park (36-26) | 64-54 | Lost 5 |
| » Starters: Dick Drago vs Jim Lonborg | Third | 9½ out |
| Saturday, August 14 |
| » Lost to Royals (62-55), 6-1 | Fenway Park (36-27) | 64-55 | Lost 6 |
| » Starters: Al Fitzmorris vs Gary Peters | Third | 9½ out |
| Sunday, August 15 |
| » Lost to Royals (63-55), 5-1 | Fenway Park (36-28) | 64-56 | Lost 7 |
| » Starters: Mike Hedlund vs Ray Culp | Third | 9½ out |
| Monday, August 16 |
| » Defeated Angels (56-67), 6-5 | Fenway Park (37-28) | 65-56 | |
| » Starters: Tom Murphy vs Sonny Siebert | Third | 9½ out |
| Tuesday, August 17 |
| » Lost to Angels (57-67), 4-3 | Fenway Park (37-29) | 65-57 | |
| » Starters: Andy Messersmith vs Ken Tatum | Third | 10½ out |
| Wednesday, August 18 |
| » Defeated Angels (57-68), 4-3 | Fenway Park (38-29) | 66-57 | |
| » Starters: Clyde Wright vs Jim Lonborg | Second | 10½ out |
| Friday, August 20 |
| » Defeated Athletics (78-45), 1-0 | Oakland-Alameda County Stadium (2-1) | 67-57 | Won 2 |
| » Starters: Gary Peters vs Vida Blue | Second | 9½ out |
| Saturday, August 21 |
| » Lost to Athletics (79-45), 4-1 | Oakland-Alameda County Stadium (2-2) | 67-58 | |
| » Starters: Ray Culp vs Catfish Hunter | Third | 10½ out |
| Sunday, August 22 |
| » Lost to Athletics (80-45), 9-3 | Oakland-Alameda County Stadium (2-3) | 67-59 | Lost 2 |
| » Starters: Roger Moret vs Blue Moon Odom | Third | 12 out |
| » Lost to Athletics (81-45), 2-1 | Oakland-Alameda County Stadium (2-4) | 67-60 | Lost 3 |
| » Starters: Sonny Siebert vs Diego Segui | Third | 12 out |
| Monday, August 23 |
| Future Red Sox Allen McDill is born in Greenville, MS. |
| Tuesday, August 24 |
| » Lost to Royals (66-60), 5-4 | Municipal Stadium (0-4) | 67-61 | Lost 4 |
| » Starters: Jim Lonborg vs Dick Drago | Third | 13 out |
| Wednesday, August 25 |
| » Lost to Royals (67-60), 7-5 | Municipal Stadium (0-5) | 67-62 | Lost 5 |
| » Starters: Gary Peters vs Al Fitzmorris | Third | 14 out |
| Thursday, August 26 |
| » Defeated Royals (67-61), 7-0 | Municipal Stadium (1-5) | 68-62 | |
| » Starters: Ray Culp vs Ken Wright | Third | 14 out |
| Friday, August 27 |
| » Lost to Angels (62-70), 1-0 | Anaheim Stadium (2-2) | 68-63 | |
| » Starters: Sonny Siebert vs Andy Messersmith | Third | 14½ out |
| Saturday, August 28 |
| » Defeated Angels (62-71), 6-2 | Anaheim Stadium (3-2) | 69-63 | |
| » Starters: Roger Moret vs Clyde Wright | Third | 14 out |
| Sunday, August 29 |
| » Lost to Angels (63-71), 2-1 | Anaheim Stadium (3-3) | 69-64 | |
| » Starters: Jim Lonborg vs Rudy May | Third | 14½ out |
| Tuesday, August 31 |
| » Defeated Orioles (81-48), 4-3 | Fenway Park (39-29) | 70-64 | |
| » Starters: Jim Palmer vs Gary Peters | Third | 13½ out |
| Wednesday, September 1 |
| » Lost to Orioles (82-48), 8-2 | Fenway Park (39-30) | 70-65 | |
| » Starters: Mike Cuellar vs Ray Culp | Third | 14½ out |
| Thursday, September 2 |
| » Defeated Orioles (82-49), 3-0 | Fenway Park (40-30) | 71-65 | |
| » Starters: Pat Dobson vs Sonny Siebert | Third | 13½ out |
| Friday, September 3 |
| » Defeated Indians (53-84), 9-2 | Fenway Park (41-30) | 72-65 | Won 2 |
| » Starters: Sam McDowell vs Roger Moret | Third | 13½ out |
| Saturday, September 4 |
| » Lost to Indians (54-84), 11-9 | Fenway Park (41-31) | 72-66 | |
| » Starters: Rich Hand vs Jim Lonborg | Third | 14½ out |
| » Major-league debuts: Juan Beniquez, Rick Miller and Ben Oglivie (Red Sox) |
| Sunday, September 5 |
| » Defeated Indians (54-85), 8-1 | Fenway Park (42-31) | 73-66 | |
| » Starters: Ed Farmer vs Gary Peters | Third | 13½ out |
| Monday, September 6 |
| » Lost to Yankees (69-71), 5-3 | Yankee Stadium (1-5) | 73-67 | |
| » Starters: Ray Culp vs Steve Kline | Third | 14½ out |
| » Lost to Yankees (70-71), 3-0 | Yankee Stadium (1-6) | 73-68 | Lost 2 |
| » Starters: John Curtis vs Stan Bahnsen | Third | 14½ out |
| Tuesday, September 7 |
| » Defeated Yankees (70-72), 9-3 | Yankee Stadium (2-6) | 74-68 | |
| » Starters: Sonny Siebert vs Fritz Peterson | Third | 14½ out |
| Wednesday, September 8 |
| » Lost to Yankees (71-72), 2-1 | Yankee Stadium (2-7) | 74-69 | |
| » Starters: Roger Moret vs Mel Stottlemyre | Third | 15 out |
| » Major-league debuts: Cecil Cooper (Red Sox) |
| Thursday, September 9 |
| » Defeated Tigers (79-63), 12-6 | Tiger Stadium (5-1) | 75-69 | |
| » Starters: Jim Lonborg vs Bill Gilbreth | Third | 15 out |
| Future Red Sox Robinson Checo is born in Santo Domingo, D.R. |
| Friday, September 10 |
| » Defeated Tigers (79-64), 6-1 | Tiger Stadium (6-1) | 76-69 | Won 2 |
| » Starters: Gary Peters vs Mickey Lolich | Third | 15 out |
| Saturday, September 11 |
| » Lost to Tigers (80-64), 1-0 | Tiger Stadium (6-2) | 76-70 | |
| » Starters: Ray Culp vs Joe Coleman | Third | 15½ out |
| Sunday, September 12 |
| » Lost to Tigers (81-64), 3-2 | Tiger Stadium (6-3) | 76-71 | Lost 2 |
| » Starters: John Curtis vs Les Cain | Third | 16 out |
| Monday, September 13 |
| » Lost to Yankees (73-73), 4-0 | Fenway Park (42-32) | 76-72 | Lost 3 |
| » Starters: Stan Bahnsen vs Sonny Siebert | Third | 16½ out |
| Tuesday, September 14 |
| » Lost to Yankees (74-73), 6-3 | Fenway Park (42-33) | 76-73 | Lost 4 |
| » Starters: Mel Stottlemyre vs Roger Moret | Third | 16½ out |
| Wednesday, September 15 |
| » Defeated Indians (57-89), 6-5 | Cleveland Stadium (4-4) | 77-73 | |
| » Starters: Jim Lonborg vs Alan Foster | Third | 15½ out |
| Thursday, September 16 |
| » Defeated Indians (57-90), 10-7 | Cleveland Stadium (5-4) | 78-73 | Won 2 |
| » Starters: Mike Garman vs Rich Hand | Third | 15½ out |
| Friday, September 17 |
|
