| Saturday, January 9 |
| Former Indian Elmer Flick dies in Bedford, OH at the age of 95. |
| Sunday, January 17 |
| Future Indian Tyler Houston is born in Long Beach, CA. |
| Tuesday, January 19 |
| Future Indian Jeff Juden is born in Salem, MA. |
| Thursday, January 21 |
| Future Indian Brian Giles is born in ElCajon, CA. |
| Friday, February 26 |
| Future Indian Matt Luke is born in Long Beach, CA. |
| Tuesday, March 2 |
| Former Indian Johnny Podgajny dies in Chester, PA at the age of 51. |
| Tuesday, April 6 |
| » Lost to Tigers (1-0), 8-2 | Tiger Stadium (0-1) | 0-1 | |
| » Starters: Steve Hargan vs Mickey Lolich | Third | 1 out |
| Thursday, April 8 |
| » Defeated Red Sox (1-1), 3-2 | Cleveland Stadium (1-0) | 1-1 | |
| » Starters: Sonny Siebert vs Sam McDowell | Second | ½ out |
| Friday, April 9 |
| » Major-league debuts: Jim Foor (Tigers) |
| Saturday, April 10 |
| » Defeated Red Sox (1-2), 11-10 | Cleveland Stadium (2-0) | 2-1 | Won 2 |
| » Starters: Cal Koonce vs Steve Hargan | Second | 1 out |
| Sunday, April 11 |
| » Defeated Red Sox (1-3), 7-2 | Cleveland Stadium (3-0) | 3-1 | Won 3 |
| » Starters: Gary Peters vs Alan Foster | Second | ½ out |
| Wednesday, April 14 |
| » Lost to Orioles (5-1), 3-0 | Cleveland Stadium (3-1) | 3-2 | |
| » Starters: Mike Cuellar vs Sam McDowell | Second | 1½ out |
| Thursday, April 15 |
| » Lost to Orioles (6-1), 6-4 | Cleveland Stadium (3-2) | 3-3 | Lost 2 |
| » Starters: Jim Palmer vs Alan Foster | Second | 2½ out |
| Former Indian Mickey Harris dies in Farmington, MI at the age of 55. |
| Saturday, April 17 |
| » Lost to Senators (5-5), 5-3 | Cleveland Stadium (3-3) | 3-4 | Lost 3 |
| » Starters: Dick Bosman vs Steve Hargan | Fourth | 3 out |
| Sunday, April 18 |
| » Lost to Senators (6-5), 4-0 | Cleveland Stadium (3-4) | 3-5 | Lost 4 |
| » Starters: Denny McLain vs Sam McDowell | Fifth | 3½ out |
| » Defeated Senators (6-6), 1-0 | Cleveland Stadium (4-4) | 4-5 | |
| » Starters: Casey Cox vs Steve Dunning | Fifth | 3½ out |
| Monday, April 19 |
| » Defeated Red Sox (5-6), 5-4 | Fenway Park (1-0) | 5-5 | Won 2 |
| » Starters: Alan Foster vs Mike Nagy | Second | 3 out |
| Tuesday, April 20 |
| » Lost to Red Sox (6-6), 4-1 | Fenway Park (1-1) | 5-6 | |
| » Starters: Camilo Pascual vs Gary Peters | Fourth | 3 out |
| Wednesday, April 21 |
| » Lost to Red Sox (7-6), 9-7 | Fenway Park (1-2) | 5-7 | Lost 2 |
| » Starters: Steve Hargan vs Ray Culp | Fifth | 3 out |
| Friday, April 23 |
| » Lost to Royals (7-9), 5-2 | Municipal Stadium (0-1) | 5-8 | Lost 3 |
| » Starters: Sam McDowell vs Dick Drago | Fifth | 4 out |
| Saturday, April 24 |
| » Lost to Royals (8-9), 6-0 | Municipal Stadium (0-2) | 5-9 | Lost 4 |
| » Starters: Alan Foster vs Mike Hedlund | Fifth | 4 out |
| Sunday, April 25 |
| » Lost to Royals (9-9), 6-4 | Municipal Stadium (0-3) | 5-10 | Lost 5 |
| » Starters: Steve Hargan vs Wally Bunker | Sixth | 5 out |
| Monday, April 26 |
| » Lost to Angels (10-9), 8-0 | Anaheim Stadium (0-1) | 5-11 | Lost 6 |
| » Starters: Steve Dunning vs Rudy May | Fifth | 5 out |
| Tuesday, April 27 |
| » Lost to Angels (11-9), 2-1 | Anaheim Stadium (0-2) | 5-12 | Lost 7 |
| » Starters: Ray Lamb vs Andy Messersmith | Sixth | 6 out |
| Wednesday, April 28 |
| » Defeated Angels (11-10), 3-2 | Anaheim Stadium (1-2) | 6-12 | |
| » Starters: Sam McDowell vs Clyde Wright | Fifth | 5 out |
| Thursday, April 29 |
| » Lost to Angels (12-10), 8-4 | Anaheim Stadium (1-3) | 6-13 | |
| » Starters: Alan Foster vs Tom Murphy | Sixth | 6 out |
| Friday, April 30 |
| » Lost to Athletics (17-8), 3-1 | Oakland-Alameda County Stadium (0-1) | 6-14 | Lost 2 |
| » Starters: Steve Hargan vs Vida Blue | Sixth | 6½ out |
| Saturday, May 1 |
| » Defeated Athletics (17-9), 2-1 | Oakland-Alameda County Stadium (1-1) | 7-14 | |
| » Starters: Steve Dunning vs Diego Segui | Sixth | 5½ out |
| Sunday, May 2 |
| » Lost to Athletics (18-9), 8-5 | Oakland-Alameda County Stadium (1-2) | 7-15 | |
| » Starters: Sam McDowell vs Catfish Hunter | Sixth | 6½ out |
| » Defeated Athletics (18-10), 7-3 | Oakland-Alameda County Stadium (2-2) | 8-15 | |
| » Starters: Ray Lamb vs Chuck Dobson | Sixth | 6½ out |
| Tuesday, May 4 |
| » Lost to Royals (13-12), 2-0 | Cleveland Stadium (4-5) | 8-16 | |
| » Starters: Bruce DalCanton vs Steve Hargan | Sixth | 7½ out |
| Wednesday, May 5 |
| » Lost to Royals (14-12), 4-2 | Cleveland Stadium (4-6) | 8-17 | Lost 2 |
| » Starters: Dick Drago vs Steve Dunning | Sixth | 8 out |
| Friday, May 7 |
| » Lost to Angels (15-14), 4-2 | Cleveland Stadium (4-7) | 8-18 | Lost 3 |
| » Starters: Clyde Wright vs Sam McDowell | Sixth | 9½ out |
| Saturday, May 8 |
| » Lost to Angels (16-14), 5-2 | Cleveland Stadium (4-8) | 8-19 | Lost 4 |
| » Starters: Rudy May vs Ray Lamb | Sixth | 10½ out |
| Sunday, May 9 |
| » Defeated Angels (16-15), 4-1 | Cleveland Stadium (5-8) | 9-19 | |
| » Starters: Tom Murphy vs Alan Foster | Fifth | 9½ out |
| Tuesday, May 11 |
| » Defeated Athletics (21-12), 7-5 | Cleveland Stadium (6-8) | 10-19 | Won 2 |
| » Starters: Diego Segui vs Steve Dunning | Sixth | 9½ out |
| Wednesday, May 12 |
| » Lost to Athletics (22-12), 8-1 | Cleveland Stadium (6-9) | 10-20 | |
| » Starters: Chuck Dobson vs Sam McDowell | Sixth | 9½ out |
| Friday, May 14 |
| » Defeated Yankees (15-15), 2-1 | Yankee Stadium (1-0) | 11-20 | |
| » Starters: Ray Lamb vs Steve Kline | Sixth | 9½ out |
| Saturday, May 15 |
| » Defeated Yankees (15-16), 4-2 | Yankee Stadium (2-0) | 12-20 | Won 2 |
| » Starters: Alan Foster vs Stan Bahnsen | Sixth | 8½ out |
| Monday, May 17 |
| » Defeated Senators (15-20), 6-3 | Robert F. Kennedy Stadium (1-0) | 13-20 | Won 3 |
| » Starters: Steve Dunning vs Dick Bosman | Sixth | 8½ out |
| Tuesday, May 18 |
| » Defeated Senators (15-21), 7-3 | Robert F. Kennedy Stadium (2-0) | 14-20 | Won 4 |
| » Starters: Sam McDowell vs Denny McLain | Sixth | 8½ out |
| Wednesday, May 19 |
| » Lost to Tigers (17-19), 12-1 | Cleveland Stadium (6-10) | 14-21 | |
| » Starters: Mickey Lolich vs Ray Lamb | Sixth | 9½ out |
| Thursday, May 20 |
| » Lost to Tigers (18-19), 5-3 | Cleveland Stadium (6-11) | 14-22 | Lost 2 |
| » Starters: Joe Coleman vs Alan Foster | Sixth | 10½ out |
| Friday, May 21 |
| » Defeated Yankees (16-20), 8-7 | Cleveland Stadium (7-11) | 15-22 | |
| » Starters: Mike Kekich vs Rich Hand | Fifth | 10½ out |
| Saturday, May 22 |
| » Defeated Yankees (16-21), 2-1 | Cleveland Stadium (8-11) | 16-22 | Won 2 |
| » Starters: Mel Stottlemyre vs Steve Dunning | Fifth | 9½ out |
| Sunday, May 23 |
| » Lost to Yankees (17-21), 6-3 | Cleveland Stadium (8-12) | 16-23 | |
| » Starters: Fritz Peterson vs Ray Lamb | Fifth | 9½ out |
| » Defeated Yankees (17-22), 2-1 | Cleveland Stadium (9-12) | 17-23 | |
| » Starters: Steve Kline vs Sam McDowell | Fifth | 9½ out |
| Wednesday, May 26 |
| » Lost to Orioles (24-16), 3-2 | Memorial Stadium (0-1) | 17-24 | |
| » Starters: Rich Hand vs Mike Cuellar | Fifth | 9½ out |
| Future Indian Jason Bere is born in Cambridge, MA. |
| Thursday, May 27 |
| » Defeated Orioles (24-17), 10-5 | Memorial Stadium (1-1) | 18-24 | |
| » Starters: Steve Dunning vs Jim Palmer | Fourth | 9½ out |
| Friday, May 28 |
| » Defeated White Sox (16-24), 4-0 | Comiskey Park I (1-0) | 19-24 | Won 2 |
| » Starters: Sam McDowell vs Bart Johnson | Fourth | 9½ out |
| » Major-league debuts: Chris Chambliss (Indians) |
| Saturday, May 29 |
| » Defeated White Sox (16-25), 2-1 | Comiskey Park I (2-0) | 20-24 | Won 3 |
| » Starters: Ray Lamb vs Tom Bradley | Fourth | 8½ out |
| Sunday, May 30 |
| » Lost to White Sox (17-25), 3-2 | Comiskey Park I (2-1) | 20-25 | |
| » Starters: Alan Foster vs Wilbur Wood | Fourth | 9 out |
| Monday, May 31 |
| » Lost to Brewers (19-25), 6-5 | County Stadium (0-1) | 20-26 | Lost 2 |
| » Starters: Rich Hand vs Skip Lockwood | Fifth | 8½ out |
| Tuesday, June 1 |
| » Lost to Brewers (20-25), 5-3 | County Stadium (0-2) | 20-27 | Lost 3 |
| » Starters: Steve Dunning vs Marty Pattin | Fifth | 8½ out |
| Wednesday, June 2 |
| » Defeated Brewers (20-26), 4-2 | County Stadium (1-2) | 21-27 | |
| » Starters: Sam McDowell vs Bill Parsons | Fifth | 7½ out |
| Friday, June 4 |
| » Defeated Twins (26-26), 4-2 | Metropolitan Stadium (1-0) | 22-27 | Won 2 |
| » Starters: Alan Foster vs Bert Blyleven | Fourth | 8 out |
| Saturday, June 5 |
| » Defeated Twins (26-27), 10-2 | Metropolitan Stadium (2-0) | 23-27 | Won 3 |
| » Starters: Ray Lamb vs Jim Kaat | Fourth | 7½ out |
| Sunday, June 6 |
| » Lost to Twins (27-27), 4-3 | Metropolitan Stadium (2-1) | 23-28 | |
| » Starters: Steve Dunning vs Jim Perry | Fourth | 8½ out |
| Tuesday, June 8 |
| » Defeated White Sox (20-29), 5-3 | Cleveland Stadium (10-12) | 24-28 | |
| » Starters: Wilbur Wood vs Sam McDowell | Fourth | 8½ out |
| Wednesday, June 9 |
| » Defeated White Sox (20-30), 3-1 | Cleveland Stadium (11-12) | 25-28 | Won 2 |
| » Starters: Tommy John vs Alan Foster | Fourth | 8½ out |
| » Major-league debuts: Ed Farmer (Indians) |
| Thursday, June 10 |
| » Defeated White Sox (20-31), 9-0 | Cleveland Stadium (12-12) | 26-28 | Won 3 |
| » Starters: Tom Bradley vs Ray Lamb | Fourth | 8½ out |
| Friday, June 11 |
| » Defeated Brewers (20-33), 2-1 | Cleveland Stadium (13-12) | 27-28 | Won 4 |
| » Starters: Marty Pattin vs Steve Dunning | Fourth | 8½ out |
| Saturday, June 12 |
| » Lost to Brewers (21-33), 4-2 | Cleveland Stadium (13-13) | 27-29 | |
| » Starters: Jim Slaton vs Rich Hand | Fourth | 8½ out |
| Sunday, June 13 |
| » Defeated Brewers (21-34), 11-0 | Cleveland Stadium (14-13) | 28-29 | |
| » Starters: Bill Parsons vs Sam McDowell | Fourth | 8½ out |
| Monday, June 14 |
| » Lost to Twins (29-32), 3-1 | Cleveland Stadium (14-14) | 28-30 | |
| » Starters: Jim Perry vs Alan Foster | Fourth | 9 out |
| Tuesday, June 15 |
| » Lost to Twins (30-32), 5-3 | Cleveland Stadium (14-15) | 28-31 | Lost 2 |
| » Starters: Bert Blyleven vs Ray Lamb | Fourth | 9 out |
| Wednesday, June 16 |
| » Lost to Twins (31-32), 3-2 | Cleveland Stadium (14-16) | 28-32 | Lost 3 |
| » Starters: Jim Kaat vs Steve Dunning | Fifth | 10 out |
| Thursday, June 17 |
| » Lost to Tigers (36-27), 4-3 | Cleveland Stadium (14-17) | 28-33 | Lost 4 |
| » Starters: Les Cain vs Sam McDowell | Fifth | 11 out |
| Friday, June 18 |
| » Defeated Tigers (36-28), 7-0 | Cleveland Stadium (15-17) | 29-33 | |
| » Starters: Joe Coleman vs Rich Hand | Fourth | 11 out |
| Saturday, June 19 |
| » Lost to Tigers (37-28), 5-3 | Cleveland Stadium (15-18) | 29-34 | |
| » Starters: Dean Chance vs Alan Foster | Fifth | 11 out |
| Sunday, June 20 |
| » Defeated Tigers (37-29), 7-6 | Cleveland Stadium (16-18) | 30-34 | |
| » Starters: Mickey Lolich vs Steve Dunning | Fourth | 11 out |
| » Game at Cleveland Stadium interrupted in the 8th inning with the score of Indians 7, Tigers 6. Completed on September 28. |
| Tuesday, June 22 |
| » Defeated Red Sox (35-30), 9-3 | Fenway Park (2-2) | 31-34 | Won 2 |
| » Starters: Steve Hargan vs Bill Lee | Fourth | 11½ out |
| » Lost to Red Sox (36-30), 2-0 | Fenway Park (2-3) | 31-35 | |
| » Starters: Rich Hand vs Sonny Siebert | Fourth | 11½ out |
| » Major-league debuts: Kurt Bevacqua (Indians) |
| Wednesday, June 23 |
| » Lost to Red Sox (37-30), 2-1 | Fenway Park (2-4) | 31-36 | Lost 2 |
| » Starters: Sam McDowell vs Ray Culp | Fifth | 12½ out |
| Thursday, June 24 |
| » Lost to Tigers (39-31), 3-0 | Tiger Stadium (0-2) | 31-37 | Lost 3 |
| » Starters: Alan Foster vs Mickey Lolich | Fifth | 13½ out |
| Friday, June 25 |
| » Lost to Tigers (40-31), 6-1 | Tiger Stadium (0-3) | 31-38 | Lost 4 |
| » Starters: Steve Dunning vs Bill Gilbreth | Fifth | 14½ out |
| » Major-league debuts: Bill Gilbreth (Tigers) |
| Saturday, June 26 |
| » Lost to Tigers (41-31), 1-0 | Tiger Stadium (0-4) | 31-39 | Lost 5 |
| » Starters: Steve Hargan vs Joe Coleman | Fifth | 14 out |
| Sunday, June 27 |
| » Defeated Tigers (41-32), 3-1 | Tiger Stadium (1-4) | 32-39 | |
| » Starters: Sam McDowell vs Mike Kilkenny | Fifth | 13 out |
| Monday, June 28 |
| » Defeated Yankees (34-40), 3-0 | Yankee Stadium (3-0) | 33-39 | Won 2 |
| » Starters: Ray Lamb vs Fritz Peterson | Fourth | 11½ out |
| » Defeated Yankees (34-41), 5-2 | Yankee Stadium (4-0) | 34-39 | Won 3 |
| » Starters: Rich Hand vs Jim Hardin | Fourth | 11½ out |
| Tuesday, June 29 |
| » Lost to Yankees (35-41), 9-2 | Yankee Stadium (4-1) | 34-40 | |
| » Starters: Alan Foster vs Steve Kline | Fifth | 12½ out |
| Wednesday, June 30 |
| » Defeated Orioles (46-28), 5-4 | Cleveland Stadium (17-18) | 35-40 | |
| » Starters: Mike Cuellar vs Steve Dunning | Fourth | 12½ out |
| » Lost to Orioles (47-28), 4-3 | Cleveland Stadium (17-19) | 35-41 | |
| » Starters: Grant Jackson vs Steve Hargan | Fourth | 12½ out |
| Thursday, July 1 |
| » Defeated Orioles (47-29), 3-2 | Cleveland Stadium (18-19) | 36-41 | |
| » Starters: Jim Palmer vs Sam McDowell | Fourth | 11½ out |
| Friday, July 2 |
| » Lost to Senators (29-47), 6-3 | Cleveland Stadium (18-20) | 36-42 | |
| » Starters: Dick Bosman vs Ray Lamb | Fourth | 11½ out |
| Saturday, July 3 |
| » Lost to Senators (30-47), 4-3 | Cleveland Stadium (18-21) | 36-43 | Lost 2 |
| » Starters: Jackie Brown vs Alan Foster | Fifth | 12½ out |
| Sunday, July 4 |
| » Lost to Senators (31-47), 9-4 | Cleveland Stadium (18-22) | 36-44 | Lost 3 |
| » Starters: Pete Broberg vs Steve Dunning | Fifth | 13½ out |
| Monday, July 5 |
| » Lost to Senators (32-47), 15-6 | Cleveland Stadium (18-23) | 36-45 | Lost 4 |
| » Starters: Denny McLain vs Steve Hargan | Fifth | 14 out |
| Tuesday, July 6 |
| » Lost to Red Sox (47-33), 3-2 | Cleveland Stadium (18-24) | 36-46 | Lost 5 |
| » Starters: Sonny Siebert vs Ray Lamb | Fifth | 14½ out |
| Wednesday, July 7 |
| » Lost to Red Sox (48-33), 4-0 | Cleveland Stadium (18-25) | 36-47 | Lost 6 |
| » Starters: Ray Culp vs Alan Foster | Fifth | 15 out |
| » Defeated Red Sox (48-34), 4-3 | Cleveland Stadium (19-25) | 37-47 | |
| » Starters: Luis Tiant vs Rich Hand | Fifth | 15 out |
| Thursday, July 8 |
| » Lost to Red Sox (49-34), 5-3 | Cleveland Stadium (19-26) | 37-48 | |
| » Starters: Jim Lonborg vs Steve Hargan | Fifth | 16 out |
| Friday, July 9 |
| » Lost to Orioles (53-31), 4-1 | Memorial Stadium (1-2) | 37-49 | Lost 2 |
| » Starters: Steve Dunning vs Jim Palmer | Fifth | 17 out |
| Saturday, July 10 |
| » Lost to Orioles (54-31), 11-3 | Memorial Stadium (1-3) | 37-50 | Lost 3 |
| » Starters: Sam McDowell vs Grant Jackson | Fifth | 17 out |
| » Defeated Orioles (54-32), 3-2 | Memorial Stadium (2-3) | 38-50 | |
| » Starters: Mike Paul vs Dave Boswell | Fifth | 17 out |
| Sunday, July 11 |
| » Lost to Orioles (55-32), 7-1 | Memorial Stadium (2-4) | 38-51 | |
| » Starters: Ed Farmer vs Pat Dobson | Fifth | 18 out |
| Monday, July 12 |
| Former Indian Walt Judnich dies in Glendale, CA at the age of 55. |
| Thursday, July 15 |
| » Lost to Royals (44-41), 1-0 | Municipal Stadium (0-4) | 38-52 | Lost 2 |
| » Starters: Sam McDowell vs Dick Drago | Fifth | 19 out |
| Friday, July 16 |
| » Defeated Royals (44-42), 8-4 | Municipal Stadium (1-4) | 39-52 | |
| » Starters: Steve Dunning vs Bruce DalCanton | Fifth | 18 out |
| » Major-league debuts: Jim Clark (Indians) |
| Saturday, July 17 |
| » Lost to Royals (45-42), 7-2 | Municipal Stadium (1-5) | 39-53 | |
| » Starters: Ray Lamb vs Mike Hedlund | Fifth | 18 out |
| Sunday, July 18 |
| » Lost to Angels (45-51), 3-1 | Anaheim Stadium (1-4) | 39-54 | Lost 2 |
| » Starters: Alan Foster vs Rudy May | Fifth | 19 out |
| Monday, July 19 |
| » Defeated Angels (45-52), 3-1 | Anaheim Stadium (2-4) | 40-54 | |
| » Starters: Sam McDowell vs Rickey Clark | Fifth | 19 out |
| Tuesday, July 20 |
| » Lost to Athletics (59-34), 6-3 | Oakland-Alameda County Stadium (2-3) | 40-55 | |
| » Starters: Ray Lamb vs Chuck Dobson | Fifth | 19 out |
| Wednesday, July 21 |
| » Lost to Athletics (60-34), 4-3 | Oakland-Alameda County Stadium (2-4) | 40-56 | Lost 2 |
| » Starters: Steve Dunning vs Vida Blue | Sixth | 19 out |
| Friday, July 23 |
| » Lost to Royals (50-44), 6-4 | Cleveland Stadium (19-27) | 40-57 | Lost 3 |
| » Starters: Paul Splittorff vs Sam McDowell | Sixth | 20½ out |
| Saturday, July 24 |
| » Lost to Royals (51-44), 6-1 | Cleveland Stadium (19-28) | 40-58 | Lost 4 |
| » Starters: Bill Butler vs Alan Foster | Sixth | 21 out |
| Sunday, July 25 |
| » Lost to Royals (52-44), 4-3 | Cleveland Stadium (19-29) | 40-59 | Lost 5 |
| » Starters: Dick Drago vs Ray Lamb | Fifth | 20 out |
| » Defeated Royals (52-45), 2-1 | Cleveland Stadium (20-29) | 41-59 | |
| » Starters: Bruce DalCanton vs Mike Paul | Fifth | 20 out |
| Tuesday, July 27 |
| » Defeated Angels (49-55), 4-3 | Cleveland Stadium (21-29) | 42-59 | Won 2 |
| » Starters: Clyde Wright vs Sam McDowell | Fifth | 20½ out |
| Wednesday, July 28 |
| » Lost to Angels (50-55), 5-1 | Cleveland Stadium (21-30) | 42-60 | |
| » Starters: Rudy May vs Steve Hargan | Fifth | 21½ out |
| Former Indian Myril Hoag dies in High Springs, FL at the age of 64. |
| Thursday, July 29 |
| » Lost to Angels (51-55), 7-2 | Cleveland Stadium (21-31) | 42-61 | Lost 2 |
| » Starters: Tom Murphy vs Mike Paul | Sixth | 22 out |
| Friday, July 30 |
| » Defeated Athletics (63-39), 4-1 | Cleveland Stadium (22-31) | 43-61 | |
| » Manager: Johnny Lipon |
| » Starters: Vida Blue vs Alan Foster | Sixth | 22 out |
| Saturday, July 31 |
| » Lost to Athletics (64-39), 9-1 | Cleveland Stadium (22-32) | 43-62 | |
| » Starters: Chuck Dobson vs Steve Dunning | Sixth | 23 out |
| Sunday, August 1 |
| » Lost to Athletics (65-39), 7-3 | Cleveland Stadium (22-33) | 43-63 | Lost 2 |
| » Starters: Catfish Hunter vs Steve Hargan | Sixth | 24 out |
| » Lost to Athletics (66-39), 4-2 | Cleveland Stadium (22-34) | 43-64 | Lost 3 |
| » Starters: Blue Moon Odom vs Vince Colbert | Sixth | 24 out |
| Monday, August 2 |
| » Lost to Yankees (53-56), 7-0 | Cleveland Stadium (22-35) | 43-65 | Lost 4 |
| » Starters: Fritz Peterson vs Mike Paul | Sixth | 24 out |
| Tuesday, August 3 |
| » Lost to Yankees (54-56), 8-1 | Cleveland Stadium (22-36) | 43-66 | Lost 5 |
| » Starters: Mike Kekich vs Alan Foster | Sixth | 24½ out |
| Wednesday, August 4 |
| » Lost to Yankees (55-56), 7-3 | Cleveland Stadium (22-37) | 43-67 | Lost 6 |
| » Starters: Stan Bahnsen vs Ray Lamb | Sixth | 25½ out |
| Thursday, August 5 |
| » Defeated Senators (44-64), 7-1 | Robert F. Kennedy Stadium (3-0) | 44-67 | |
| » Starters: Vince Colbert vs Mike Thompson | Sixth | 24½ out |
| Friday, August 6 |
| » Lost to Senators (45-64), 7-3 | Robert F. Kennedy Stadium (3-1) | 44-68 | |
| » Starters: Steve Hargan vs Bill Gogolewski | Sixth | 24½ out |
| Saturday, August 7 |
| » Lost to Senators (46-64), 7-0 | Robert F. Kennedy Stadium (3-2) | 44-69 | Lost 2 |
| » Starters: Mike Paul vs Pete Broberg | Sixth | 25½ out |
| Sunday, August 8 |
| » Defeated Senators (46-65), 6-2 | Robert F. Kennedy Stadium (4-2) | 45-69 | |
| » Starters: Steve Dunning vs Denny McLain | Sixth | 24½ out |
| Tuesday, August 10 |
| » Defeated White Sox (55-60), 4-1 | Comiskey Park I (3-1) | 46-69 | Won 2 |
| » Starters: Sam McDowell vs Tom Bradley | Sixth | 24½ out |
| Wednesday, August 11 |
| » Defeated White Sox (55-61), 3-2 | Comiskey Park I (4-1) | 47-69 | Won 3 |
| » Starters: Ray Lamb vs Joe Horlen | Fifth | 24½ out |
| Thursday, August 12 |
| » Defeated White Sox (55-62), 6-2 | Comiskey Park I (5-1) | 48-69 | Won 4 |
| » Starters: Mike Paul vs Wilbur Wood | Fifth | 24½ out |
| Friday, August 13 |
| » Lost to Brewers (49-67), 9-1 | County Stadium (1-3) | 48-70 | |
| » Starters: Steve Dunning vs Jim Slaton | Sixth | 25½ out |
| Saturday, August 14 |
| » Lost to Brewers (50-67), 5-3 | County Stadium (1-4) | 48-71 | Lost 2 |
| » Starters: Vince Colbert vs Lew Krausse | Sixth | 25½ out |
| Sunday, August 15 |
| » Lost to Brewers (51-67), 4-2 | County Stadium (1-5) | 48-72 | Lost 3 |
| » Starters: Sam McDowell vs Bill Parsons | Sixth | 25½ out |
| Monday, August 16 |
| » Lost to Twins (54-65), 11-2 | Metropolitan Stadium (2-2) | 48-73 | Lost 4 |
| » Starters: Ray Lamb vs Jim Kaat | Sixth | 26½ out |
| Tuesday, August 17 |
| » Defeated Twins (54-66), 3-2 | Metropolitan Stadium (3-2) | 49-73 | |
| » Starters: Mike Paul vs Bert Blyleven | Sixth | 26½ out |
| Wednesday, August 18 |
| » Lost to Twins (55-66), 4-2 | Metropolitan Stadium (3-3) | 49-74 | |
| » Starters: Steve Dunning vs Steve Luebber | Sixth | 27½ out |
| Future Indian Albie Lopez is born in Mesa, AZ. |
| Friday, August 20 |
| » Lost to White Sox (61-63), 9-1 | Cleveland Stadium (22-38) | 49-75 | Lost 2 |
| » Starters: Tom Bradley vs Vince Colbert | Sixth | 27½ out |
| Saturday, August 21 |
| » Defeated White Sox (61-64), 9-4 | Cleveland Stadium (23-38) | 50-75 | |
| » Starters: Tommy John vs Ray Lamb | Sixth | 27½ out |
| Sunday, August 22 |
| » Lost to White Sox (62-64), 5-3 | Cleveland Stadium (23-39) | 50-76 | |
| » Starters: Wilbur Wood vs Steve Dunning | Sixth | 28½ out |
| Tuesday, August 24 |
| » Lost to Brewers (53-72), 6-5 | Cleveland Stadium (23-40) | 50-77 | Lost 2 |
| » Starters: Jim Slaton vs Alan Foster | Sixth | 29½ out |
| Wednesday, August 25 |
| » Lost to Brewers (54-72), 10-8 | Cleveland Stadium (23-41) | 50-78 | Lost 3 |
| » Starters: Bill Parsons vs Mike Paul | Sixth | 30½ out |
| Thursday, August 26 |
| » Defeated Brewers (54-73), 10-6 | Cleveland Stadium (24-41) | 51-78 | |
| » Starters: Skip Lockwood vs Ray Lamb | Sixth | 30½ out |
| Friday, August 27 |
| » Lost to Twins (58-70), 8-4 | Cleveland Stadium (24-42) | 51-79 | |
| » Starters: Bert Blyleven vs Steve Dunning | Sixth | 31 out |
| Saturday, August 28 |
| » Defeated Twins (58-71), 9-8 | Cleveland Stadium (25-42) | 52-79 | |
| » Starters: Steve Luebber vs Alan Foster | Sixth | 30½ out |
| Sunday, August 29 |
| » Lost to Twins (59-71), 6-5 | Cleveland Stadium (25-43) | 52-80 | |
| » Starters: Jim Perry vs Sam McDowell | Sixth | 31 out |
| Tuesday, August 31 |
| » Lost to Tigers (72-60), 6-1 | Tiger Stadium (1-5) | 52-81 | Lost 2 |
| » Starters: Ed Farmer vs Joe Coleman | Sixth | 30½ out |
| » Defeated Tigers (72-61), 6-3 | Tiger Stadium (2-5) | 53-81 | |
| » Starters: Vince Colbert vs Joe Niekro | Sixth | 30½ out |
| Wednesday, September 1 |
| » Lost to Tigers (73-61), 4-3 | Tiger Stadium (2-6) | 53-82 | |
| » Starters: Mike Paul vs Les Cain | Sixth | 31½ out |
| Thursday, September 2 |
| » Lost to Tigers (74-61), 7-0 | Tiger Stadium (2-7) | 53-83 | Lost 2 |
| » Starters: Steve Dunning vs Mickey Lolich | Sixth | 31½ out |
| Friday, September 3 |
| » Lost to Red Sox (72-65), 9-2 | Fenway Park (2-5) | 53-84 | Lost 3 |
| » Starters: Sam McDowell vs Roger Moret | Sixth | 32½ out |
| Saturday, September 4 |
| » Defeated Red Sox (72-66), 11-9 | Fenway Park (3-5) | 54-84 | |
| » Starters: Rich Hand vs Jim Lonborg | Sixth | 32½ out |
| » Major-league debuts: Juan Beniquez Rick Miller and Ben Oglivie (Red Sox) |
| Sunday, September 5 |
| » Lost to Red Sox (73-66), 8-1 | Fenway Park (3-6) | 54-85 | |
| » Starters: Ed Farmer vs Gary Peters | Sixth | 32½ out |
| Monday, September 6 |
| » Lost to Orioles (85-50), 10-5 | Memorial Stadium (2-5) | 54-86 | Lost 2 |
| » Starters: Mike Paul vs Pat Dobson | Sixth | 32½ out |
| » Defeated Orioles (85-51), 1-0 | Memorial Stadium (3-5) | 55-86 | |
| » Starters: Vince Colbert vs Dave Leonhard | Sixth | 32½ out |
| Tuesday, September 7 |
| » Lost to Orioles (86-51), 3-1 | Memorial Stadium (3-6) | 55-87 | |
| » Starters: Sam McDowell vs Dave McNally | Sixth | 33½ out |
| Saturday, September 11 |
| » Lost to Yankees (72-72), 10-8 | Cleveland Stadium (25-44) | 55-88 | Lost 2 |
| » Starters: Mike Kekich vs Rich Hand | Sixth | 35 out |
| Sunday, September 12 |
| » Defeated Yankees (72-73), 5-2 | Cleveland Stadium (26-44) | 56-88 | |
| » Starters: Fritz Peterson vs Sam McDowell | Sixth | 34½ out |
| Tuesday, September 14 |
| » Defeated Senators (58-86), 3-1 | Cleveland Stadium (27-44) | 57-88 | Won 2 |
| » Starters: Bill Gogolewski vs Vince Colbert | Sixth | 33½ out |
| » Game at Robert F. Kennedy Stadium interrupted in the 17th inning with the score of Senators 5, Indians 5. Completed on September 20. |
| Wednesday, September 15 |
| » Lost to Red Sox (77-73), 6-5 | Cleveland Stadium (27-45) | 57-89 | |
| » Starters: Jim Lonborg vs Alan Foster | Sixth | 33½ out |
| Thursday, September 16 |
| » Lost to Red Sox (78-73), 10-7 | Cleveland Stadium (27-46) | 57-90 | Lost 2 |
| » Starters: Mike Garman vs Rich Hand | Sixth | 34½ out |
| Friday, September 17 |
| » Lost to Yankees (76-74), 1-0 | Yankee Stadium (4-2) | 57-91 | Lost 3 |
| » Starters: Sam McDowell vs Fritz Peterson | Sixth | 34½ out |
| » Lost to Yankees (77-74), 7-1 | Yankee Stadium (4-3) | 57-92 | Lost 4 |
| » Starters: Mike Paul vs Stan Bahnsen | Sixth | 34½ out |
| Saturday, September 18 |
| » Lost to Yankees (78-74), 9-0 | Yankee Stadium (4-4) | 57-93 | Lost 5 |
| » Starters: Vince Colbert vs Mel Stottlemyre | Sixth | 34½ out |
| Sunday, September 19 |
| » Lost to Yankees (79-74), 3-2 | Yankee Stadium (4-5) | 57-94 | Lost 6 |
| » Starters: Steve Dunning vs Steve Kline | Sixth | 35½ out |
| Monday, September 20 |
| » Defeated Senators (59-91), 3-1 | Robert F. Kennedy Stadium (5-2) | 58-94 | |
| » Starters: Alan Foster vs Denny McLain | Sixth | 36 out |
| » Lost to Senators (60-91), 8-6 | Cleveland Stadium (27-47) | 58-95 | |
| » Starters: Pete Broberg vs Steve Dunning | Sixth | 36 out |
| Tuesday, September 21 |
| » Lost to Senators (61-91), 9-1 | Robert F. Kennedy Stadium (5-3) | 58-96 | Lost 2 |
| » Starters: Rich Hand vs Dick Bosman | Sixth | |
