| Friday, January 2 |
| Future White Sox Royce Clayton is born in Burbank, CA. |
| Sunday, January 18 |
| Future White Sox Mike Bertotti is born in Jersey City, NJ. |
| Friday, January 23 |
| Future White Sox Alan Embree is born in The Dalles, OR. |
| Saturday, January 24 |
| Former White Sox Hal McKain dies in Sacramento, CA at the age of 64. |
| Friday, March 13 |
| Future White Sox Jorge Fabregas is born in Miami, FL. |
| Tuesday, March 24 |
| Future White Sox Wilson Alvarez is born in Maracaibo, Venezuela. |
| Monday, April 6 |
| » Major-league debuts: Dick Such (Senators) |
| Tuesday, April 7 |
| » Lost to Twins (1-0), 12-0 | Comiskey Park I (0-1) | 0-1 | |
| » Starters: Jim Perry vs Tommy John | Second | 1 out |
| Thursday, April 9 |
| » Lost to Twins (2-0), 6-4 | Comiskey Park I (0-2) | 0-2 | Lost 2 |
| » Starters: Luis Tiant vs Joe Horlen | Fourth | 2 out |
| » Major-league debuts: Steve Barber (Twins) |
| Friday, April 10 |
| » Defeated Brewers (0-3), 5-4 | Comiskey Park I (1-2) | 1-2 | |
| » Starters: Gene Brabender vs Jerry Janeski | Fourth | 2 out |
| Saturday, April 11 |
| » Lost to Brewers (1-3), 8-4 | Comiskey Park I (1-3) | 1-3 | |
| » Starters: Bobby Bolin vs Billy Wynne | Fourth | 3 out |
| Former White Sox Joe Heving dies in Covington, KY at the age of 70. |
| Sunday, April 12 |
| » Lost to Brewers (2-3), 5-2 | Comiskey Park I (1-4) | 1-4 | Lost 2 |
| » Starters: Lew Krausse vs Tommy John | Sixth | 4½ out |
| » Lost to Brewers (3-3), 16-2 | Comiskey Park I (1-5) | 1-5 | Lost 3 |
| » Starters: George Lauzerique vs Gerry Arrigo | Sixth | 4½ out |
| Tuesday, April 14 |
| » Defeated Angels (5-1), 3-1 | Anaheim Stadium (1-0) | 2-5 | |
| » Starters: Joe Horlen vs Clyde Wright | Sixth | 3 out |
| Wednesday, April 15 |
| » Defeated Athletics (3-4), 7-0 | Oakland-Alameda County Stadium (1-0) | 3-5 | Won 2 |
| » Starters: Jerry Janeski vs Chuck Dobson | Fourth | 3 out |
| Thursday, April 16 |
| » Lost to Athletics (4-4), 3-1 | Oakland-Alameda County Stadium (1-1) | 3-6 | |
| » Starters: Tommy John vs Blue Moon Odom | Fifth | 3 out |
| Friday, April 17 |
| Former White Sox Dick Brown dies in Baltimore, MD at the age of 36. |
| Saturday, April 18 |
| » Defeated Brewers (3-7), 8-5 | County Stadium (1-0) | 4-6 | |
| » Starters: Billy Wynne vs Bobby Bolin | Fifth | 2½ out |
| Tuesday, April 21 |
| » Lost to Twins (7-2), 4-3 | Metropolitan Stadium (0-1) | 4-7 | |
| » Starters: Tommy John vs Jim Kaat | Fifth | 4 out |
| Wednesday, April 22 |
| » Lost to Twins (8-2), 3-1 | Metropolitan Stadium (0-2) | 4-8 | Lost 2 |
| » Starters: Joe Horlen vs Luis Tiant | Fifth | 5 out |
| Thursday, April 23 |
| » Defeated Twins (8-3), 7-5 | Metropolitan Stadium (1-2) | 5-8 | |
| » Starters: Jerry Janeski vs Bill Zepp | Fifth | 4 out |
| Friday, April 24 |
| » Lost to Indians (4-8), 4-1 | Cleveland Stadium (0-1) | 5-9 | |
| » Starters: Gerry Arrigo vs Barry Moore | Fifth | 4½ out |
| Saturday, April 25 |
| » Lost to Indians (5-8), 6-5 | Cleveland Stadium (0-2) | 5-10 | Lost 2 |
| » Starters: Tommy John vs Steve Hargan | Fifth | 5 out |
| Sunday, April 26 |
| » Defeated Indians (5-9), 2-0 | Cleveland Stadium (1-2) | 6-10 | |
| » Starters: Joe Horlen vs Dean Chance | Fourth | 5 out |
| Tuesday, April 28 |
| » Lost to Orioles (12-5), 4-2 | Comiskey Park I (1-6) | 6-11 | |
| » Starters: Mike Cuellar vs Jerry Janeski | Fourth | 5½ out |
| Wednesday, April 29 |
| » Lost to Orioles (13-5), 18-2 | Comiskey Park I (1-7) | 6-12 | Lost 2 |
| » Starters: Jim Palmer vs Tommie Sisk | Fourth | 6½ out |
| Thursday, April 30 |
| » Defeated Orioles (13-6), 6-3 | Comiskey Park I (2-7) | 7-12 | |
| » Starters: Tom Phoebus vs Tommy John | Fourth | 5½ out |
| Friday, May 1 |
| » Defeated Tigers (12-7), 13-6 | Comiskey Park I (3-7) | 8-12 | Won 2 |
| » Starters: Les Cain vs Joe Horlen | Fourth | 4½ out |
| Saturday, May 2 |
| » Defeated Tigers (12-8), 3-2 | Comiskey Park I (4-7) | 9-12 | Won 3 |
| » Starters: Joe Niekro vs Jerry Janeski | Fourth | 4½ out |
| Sunday, May 3 |
| » Lost to Tigers (13-8), 6-5 | Comiskey Park I (4-8) | 9-13 | |
| » Starters: Mike Kilkenny vs Billy Wynne | Fourth | 5½ out |
| Tuesday, May 5 |
| » Defeated Indians (9-13), 2-1 | Comiskey Park I (5-8) | 10-13 | |
| » Starters: Dean Chance vs Tommy John | Fourth | 5½ out |
| Wednesday, May 6 |
| » Defeated Indians (9-14), 2-1 | Comiskey Park I (6-8) | 11-13 | Won 2 |
| » Starters: Sam McDowell vs Joe Horlen | Fourth | 4½ out |
| Thursday, May 7 |
| Future White Sox Brook Fordyce is born in New London, CT. |
| Friday, May 8 |
| » Lost to Orioles (18-8), 6-1 | Memorial Stadium (0-1) | 11-14 | |
| » Starters: Jerry Janeski vs Jim Palmer | Fourth | 6 out |
| Saturday, May 9 |
| » Lost to Orioles (19-8), 4-3 | Memorial Stadium (0-2) | 11-15 | Lost 2 |
| » Starters: Tommy John vs Tom Phoebus | Fourth | 7 out |
| Sunday, May 10 |
| » Lost to Orioles (20-8), 7-2 | Memorial Stadium (0-3) | 11-16 | Lost 3 |
| » Starters: Gerry Arrigo vs Dave McNally | Fourth | 7½ out |
| » Lost to Orioles (21-8), 4-2 | Memorial Stadium (0-4) | 11-17 | Lost 4 |
| » Starters: Joe Horlen vs Jim Hardin | Fourth | 7½ out |
| Monday, May 11 |
| » Defeated Tigers (15-13), 9-5 | Tiger Stadium (1-0) | 12-17 | |
| » Starters: Billy Wynne vs Joe Niekro | Fourth | 7 out |
| Tuesday, May 12 |
| » Defeated Tigers (15-14), 7-2 | Tiger Stadium (2-0) | 13-17 | Won 2 |
| » Starters: Jerry Janeski vs Les Cain | Fourth | 7 out |
| Friday, May 15 |
| » Defeated Royals (11-20), 9-3 | Comiskey Park I (7-8) | 14-17 | Won 3 |
| » Starters: Roger Nelson vs Joe Horlen | Fourth | 7½ out |
| Saturday, May 16 |
| » Defeated Royals (11-21), 6-1 | Comiskey Park I (8-8) | 15-17 | Won 4 |
| » Starters: Bob Johnson vs Tommy John | Fourth | 6½ out |
| Sunday, May 17 |
| » Lost to Royals (12-21), 3-2 | Comiskey Park I (8-9) | 15-18 | |
| » Starters: Dick Drago vs Jerry Janeski | Fourth | 8 out |
| » Lost to Royals (13-21), 8-4 | Comiskey Park I (8-10) | 15-19 | Lost 2 |
| » Starters: Jim Rooker vs Bart Johnson | Fourth | 8 out |
| Monday, May 18 |
| » Lost to Angels (24-12), 6-1 | Comiskey Park I (8-11) | 15-20 | Lost 3 |
| » Starters: Andy Messersmith vs Billy Wynne | Fourth | 9 out |
| Tuesday, May 19 |
| » Lost to Angels (25-12), 3-0 | Comiskey Park I (8-12) | 15-21 | Lost 4 |
| » Starters: Rudy May vs Joe Horlen | Fourth | 10 out |
| Former White Sox Ray Schalk dies in Chicago, IL at the age of 78. |
| Wednesday, May 20 |
| » Defeated Angels (25-13), 3-2 | Comiskey Park I (9-12) | 16-21 | |
| » Starters: Tom Murphy vs Tommy John | Fourth | 10 out |
| Friday, May 22 |
| » Lost to Athletics (19-20), 9-8 | Comiskey Park I (9-13) | 16-22 | |
| » Starters: Blue Moon Odom vs Jerry Janeski | Fourth | 10 out |
| Saturday, May 23 |
| » Lost to Athletics (20-20), 12-2 | Comiskey Park I (9-14) | 16-23 | Lost 2 |
| » Starters: Catfish Hunter vs Joe Horlen | Fourth | 11 out |
| Sunday, May 24 |
| » Lost to Athletics (21-20), 5-1 | Comiskey Park I (9-15) | 16-24 | Lost 3 |
| » Starters: Chuck Dobson vs Tommy John | Fifth | 11½ out |
| » Lost to Athletics (22-20), 5-2 | Comiskey Park I (9-16) | 16-25 | Lost 4 |
| » Starters: Blue Moon Odom vs Bart Johnson | Fifth | 11½ out |
| Monday, May 25 |
| » Lost to Royals (17-24), 7-1 | Municipal Stadium (0-1) | 16-26 | Lost 5 |
| » Starters: Jerry Crider vs Dave Morehead | Fifth | 12½ out |
| Tuesday, May 26 |
| » Defeated Royals (17-25), 3-1 | Municipal Stadium (1-1) | 17-26 | |
| » Starters: Jerry Janeski vs Bob Johnson | Fifth | 12½ out |
| Wednesday, May 27 |
| » Lost to Royals (18-25), 4-3 | Municipal Stadium (1-2) | 17-27 | |
| » Starters: Joe Horlen vs Dick Drago | Fifth | 13 out |
| Friday, May 29 |
| » Lost to Red Sox (19-24), 4-3 | Fenway Park (0-1) | 17-28 | Lost 2 |
| » Starters: Tommy John vs Sonny Siebert | Fifth | 13½ out |
| Saturday, May 30 |
| » Lost to Red Sox (20-24), 7-5 | Fenway Park (0-2) | 17-29 | Lost 3 |
| » Starters: Bart Johnson vs Mike Nagy | Fifth | 14½ out |
| Sunday, May 31 |
| » Defeated Red Sox (20-25), 22-13 | Fenway Park (1-2) | 18-29 | |
| » Starters: Jerry Janeski vs Gary Peters | Fifth | 14½ out |
| Tuesday, June 2 |
| » Lost to Senators (23-24), 4-3 | Robert F. Kennedy Stadium (0-1) | 18-30 | |
| » Starters: Joe Horlen vs George Brunet | Fifth | 14½ out |
| Wednesday, June 3 |
| » Lost to Senators (24-24), 5-4 | Robert F. Kennedy Stadium (0-2) | 18-31 | Lost 2 |
| » Starters: Tommy John vs Joe Coleman | Fifth | 15 out |
| Thursday, June 4 |
| » Defeated Senators (24-25), 7-3 | Robert F. Kennedy Stadium (1-2) | 19-31 | |
| » Starters: Jerry Crider vs Dick Bosman | Fifth | 14 out |
| Friday, June 5 |
| » Lost to Yankees (30-23), 10-1 | Yankee Stadium (0-1) | 19-32 | |
| » Starters: Jerry Janeski vs Mel Stottlemyre | Fifth | 15 out |
| Saturday, June 6 |
| » Lost to Yankees (31-23), 3-1 | Yankee Stadium (0-2) | 19-33 | Lost 2 |
| » Starters: Joe Horlen vs John Cumberland | Fifth | 16 out |
| Sunday, June 7 |
| » Defeated Yankees (31-24), 4-3 | Yankee Stadium (1-2) | 20-33 | |
| » Starters: Tommy John vs Fritz Peterson | Fourth | 16 out |
| Monday, June 8 |
| » Lost to Brewers (17-36), 5-2 | County Stadium (1-1) | 20-34 | |
| » Starters: Bart Johnson vs Lew Krausse | Fourth | 16½ out |
| Tuesday, June 9 |
| » Defeated Red Sox (25-26), 4-2 | Comiskey Park I (10-16) | 21-34 | |
| » Starters: Sonny Siebert vs Jerry Janeski | Fourth | 15½ out |
| Wednesday, June 10 |
| » Lost to Red Sox (26-26), 7-6 | Comiskey Park I (10-17) | 21-35 | |
| » Starters: Mike Nagy vs Joe Horlen | Fourth | 15½ out |
| Friday, June 12 |
| » Defeated Senators (25-30), 6-0 | Comiskey Park I (11-17) | 22-35 | |
| » Starters: George Brunet vs Tommy John | Fourth | 15½ out |
| Saturday, June 13 |
| » Lost to Senators (26-30), 12-7 | Comiskey Park I (11-18) | 22-36 | |
| » Starters: Joe Grzenda vs Jerry Janeski | Fourth | 15½ out |
| Sunday, June 14 |
| » Lost to Senators (27-30), 8-4 | Comiskey Park I (11-19) | 22-37 | Lost 2 |
| » Starters: Dick Bosman vs Joe Horlen | Fourth | 17 out |
| » Lost to Senators (28-30), 5-3 | Comiskey Park I (11-20) | 22-38 | Lost 3 |
| » Starters: Casey Cox vs Jerry Crider | Fourth | 17 out |
| Tuesday, June 16 |
| » Lost to Yankees (37-24), 6-2 | Comiskey Park I (11-21) | 22-39 | Lost 4 |
| » Starters: Mel Stottlemyre vs Tommy John | Fourth | 18½ out |
| Wednesday, June 17 |
| » Defeated Yankees (37-25), 6-3 | Comiskey Park I (12-21) | 23-39 | |
| » Starters: Fritz Peterson vs Jerry Janeski | Fourth | 17½ out |
| Friday, June 19 |
| » Defeated Athletics (34-30), 4-2 | Oakland-Alameda County Stadium (2-1) | 24-39 | Won 2 |
| » Starters: Joe Horlen vs Blue Moon Odom | Fourth | 16½ out |
| Saturday, June 20 |
| » Lost to Athletics (35-30), 8-5 | Oakland-Alameda County Stadium (2-2) | 24-40 | |
| » Starters: Barry Moore vs Chuck Dobson | Fourth | 16½ out |
| Sunday, June 21 |
| » Lost to Athletics (36-30), 6-3 | Oakland-Alameda County Stadium (2-3) | 24-41 | Lost 2 |
| » Starters: Tommy John vs Catfish Hunter | Fifth | 18 out |
| » Lost to Athletics (37-30), 5-4 | Oakland-Alameda County Stadium (2-4) | 24-42 | Lost 3 |
| » Starters: Bob Miller vs Rollie Fingers | Fifth | 18 out |
| Tuesday, June 23 |
| » Defeated Angels (37-28), 7-3 | Anaheim Stadium (2-0) | 25-42 | |
| » Starters: Jerry Janeski vs Andy Messersmith | Fourth | 17½ out |
| Wednesday, June 24 |
| » Lost to Angels (38-28), 3-1 | Anaheim Stadium (2-1) | 25-43 | |
| » Starters: Joe Horlen vs Tom Murphy | Fifth | 19 out |
| » Lost to Angels (39-28), 2-1 | Anaheim Stadium (2-2) | 25-44 | Lost 2 |
| » Starters: Barry Moore vs Mel Queen | Fifth | 19 out |
| Thursday, June 25 |
| » Lost to Angels (40-28), 7-3 | Anaheim Stadium (2-3) | 25-45 | Lost 3 |
| » Starters: Tommy John vs Clyde Wright | Fifth | 19 out |
| Friday, June 26 |
| » Defeated Twins (41-24), 4-2 | Comiskey Park I (13-21) | 26-45 | |
| » Starters: Jim Kaat vs Bob Miller | Fourth | 18 out |
| » Major-league debuts: Rich McKinney (White Sox) |
| Saturday, June 27 |
| » Lost to Twins (42-24), 9-1 | Comiskey Park I (13-22) | 26-46 | |
| » Starters: Bert Blyleven vs Jerry Janeski | Fifth | 19 out |
| Sunday, June 28 |
| » Lost to Twins (43-24), 9-1 | Comiskey Park I (13-23) | 26-47 | Lost 2 |
| » Starters: Tom Hall vs Joe Horlen | Fifth | 19 out |
| » Defeated Twins (43-25), 11-10 | Comiskey Park I (14-23) | 27-47 | |
| » Starters: Dave Boswell vs Barry Moore | Fifth | 19 out |
| Tuesday, June 30 |
| » Lost to Athletics (42-33), 4-3 | Comiskey Park I (14-24) | 27-48 | |
| » Starters: Catfish Hunter vs Tommy John | Fifth | 20½ out |
| Wednesday, July 1 |
| » Lost to Athletics (43-33), 3-0 | Comiskey Park I (14-25) | 27-49 | Lost 2 |
| » Starters: Rollie Fingers vs Jerry Janeski | Fifth | 21½ out |
| Thursday, July 2 |
| » Lost to Athletics (44-33), 10-6 | Comiskey Park I (14-26) | 27-50 | Lost 3 |
| » Starters: Diego Segui vs Barry Moore | Fifth | 22½ out |
| Friday, July 3 |
| » Lost to Twins (48-25), 8-2 | Metropolitan Stadium (1-3) | 27-51 | Lost 4 |
| » Starters: Joe Horlen vs Jim Perry | Fifth | 23½ out |
| Saturday, July 4 |
| » Defeated Twins (48-26), 5-3 | Metropolitan Stadium (2-3) | 28-51 | |
| » Starters: Tommy John vs Dave Boswell | Fifth | 22½ out |
| Sunday, July 5 |
| » Lost to Twins (49-26), 12-3 | Metropolitan Stadium (2-4) | 28-52 | |
| » Starters: Bob Miller vs Jim Kaat | Fifth | 23½ out |
| Monday, July 6 |
| » Lost to Brewers (28-53), 3-1 | County Stadium (1-2) | 28-53 | Lost 2 |
| » Starters: Jerry Janeski vs Gene Brabender | Fifth | 24½ out |
| Tuesday, July 7 |
| » Lost to Brewers (29-53), 4-3 | County Stadium (1-3) | 28-54 | Lost 3 |
| » Starters: Jim Magnuson vs Marty Pattin | Sixth | 26 out |
| » Lost to Brewers (30-53), 1-0 | County Stadium (1-4) | 28-55 | Lost 4 |
| » Starters: Joe Horlen vs Lew Krausse | Sixth | 26 out |
| Wednesday, July 8 |
| » Defeated Brewers (30-54), 2-1 | County Stadium (2-4) | 29-55 | |
| » Starters: Tommy John vs Al Downing | Sixth | 26 out |
| Thursday, July 9 |
| » Defeated Brewers (30-55), 6-5 | County Stadium (3-4) | 30-55 | Won 2 |
| » Starters: Jerry Crider vs Skip Lockwood | Fifth | 26 out |
| Friday, July 10 |
| » Lost to Royals (31-51), 8-6 | Municipal Stadium (1-3) | 30-56 | |
| » Starters: Jerry Janeski vs Bob Johnson | Sixth | 26½ out |
| » Lost to Royals (32-51), 2-0 | Municipal Stadium (1-4) | 30-57 | Lost 2 |
| » Starters: Bob Miller vs Jim Rooker | Sixth | 26½ out |
| Saturday, July 11 |
| » Lost to Royals (33-51), 4-0 | Municipal Stadium (1-5) | 30-58 | Lost 3 |
| » Starters: Joe Horlen vs Bill Butler | Sixth | 27½ out |
| Sunday, July 12 |
| » Defeated Royals (33-52), 10-5 | Municipal Stadium (2-5) | 31-58 | |
| » Starters: Tommy John vs Dick Drago | Sixth | 26½ out |
| Thursday, July 16 |
| » Lost to Tigers (48-38), 11-6 | Comiskey Park I (14-27) | 31-59 | |
| » Starters: Les Cain vs Jerry Janeski | Sixth | 26½ out |
| Friday, July 17 |
| » Lost to Tigers (49-38), 4-3 | Comiskey Park I (14-28) | 31-60 | Lost 2 |
| » Starters: Denny McLain vs Tommy John | Sixth | 27½ out |
| Saturday, July 18 |
| » Lost to Tigers (50-38), 5-4 | Comiskey Park I (14-29) | 31-61 | Lost 3 |
| » Starters: Mickey Lolich vs Jim Magnuson | Sixth | 28½ out |
| Sunday, July 19 |
| » Lost to Orioles (56-35), 8-2 | Comiskey Park I (14-30) | 31-62 | Lost 4 |
| » Starters: Jim Palmer vs Joe Horlen | Sixth | 28 out |
| » Defeated Orioles (56-36), 7-3 | Comiskey Park I (15-30) | 32-62 | |
| » Starters: Tom Phoebus vs Bob Miller | Sixth | 28 out |
| Monday, July 20 |
| » Lost to Orioles (57-36), 14-5 | Comiskey Park I (15-31) | 32-63 | |
| » Starters: Mike Cuellar vs Jerry Janeski | Sixth | 29 out |
| Tuesday, July 21 |
| » Defeated Indians (42-50), 5-3 | Cleveland Stadium (2-2) | 33-63 | |
| » Starters: Tommy John vs Steve Dunning | Sixth | 28 out |
| Wednesday, July 22 |
| » Lost to Indians (43-50), 6-2 | Cleveland Stadium (2-3) | 33-64 | |
| » Starters: Jim Magnuson vs Steve Hargan | Sixth | 29 out |
| Thursday, July 23 |
| » Lost to Indians (44-50), 5-2 | Cleveland Stadium (2-4) | 33-65 | Lost 2 |
| » Starters: Joe Horlen vs Sam McDowell | Sixth | 30 out |
| Friday, July 24 |
| » Defeated Tigers (53-42), 5-2 | Tiger Stadium (3-0) | 34-65 | |
| » Starters: Bob Miller vs Les Cain | Sixth | 30½ out |
| » Lost to Tigers (54-42), 5-4 | Tiger Stadium (3-1) | 34-66 | |
| » Starters: Jerry Janeski vs Mike Kilkenny | Sixth | 30½ out |
| Saturday, July 25 |
| » Lost to Tigers (55-42), 9-4 | Tiger Stadium (3-2) | 34-67 | Lost 2 |
| » Starters: Jerry Crider vs Denny McLain | Sixth | 30½ out |
| Sunday, July 26 |
| » Defeated Tigers (55-43), 4-0 | Tiger Stadium (4-2) | 35-67 | |
| » Starters: Tommy John vs Mickey Lolich | Fifth | 29½ out |
| Monday, July 27 |
| Former White Sox Whitey Platt dies in W.Palm Beach, FL at the age of 50. |
| Tuesday, July 28 |
| » Lost to Orioles (63-38), 4-2 | Memorial Stadium (0-5) | 35-68 | |
| » Starters: Joe Horlen vs Mike Cuellar | Fifth | 31 out |
| Wednesday, July 29 |
| » Defeated Orioles (63-39), 2-1 | Memorial Stadium (1-5) | 36-68 | |
| » Starters: Bob Miller vs Jim Hardin | Fifth | 30 out |
| Friday, July 31 |
| » Defeated Indians (49-54), 5-4 | Comiskey Park I (16-31) | 37-68 | Won 2 |
| » Starters: Steve Dunning vs Tommy John | Sixth | 28½ out |
| Saturday, August 1 |
| » Lost to Indians (50-54), 3-2 | Comiskey Park I (16-32) | 37-69 | |
| » Starters: Sam McDowell vs Jerry Janeski | Sixth | 29½ out |
| Sunday, August 2 |
| » Lost to Indians (51-54), 4-2 | Comiskey Park I (16-33) | 37-70 | Lost 2 |
| » Starters: Rich Hand vs Jerry Crider | Fifth | 30 out |
| » Defeated Indians (51-55), 8-7 | Comiskey Park I (17-33) | 38-70 | |
| » Starters: Dean Chance vs Floyd Weaver | Fifth | 30 out |
| Former White Sox Mike Cvengros dies in Hot Springs, AR at the age of 69. |
| Monday, August 3 |
| » Lost to Royals (39-67), 7-2 | Comiskey Park I (17-34) | 38-71 | |
| » Starters: Bob Johnson vs Bob Miller | Sixth | 30½ out |
| Tuesday, August 4 |
| » Defeated Royals (39-68), 2-1 | Comiskey Park I (18-34) | 39-71 | |
| » Starters: Bill Butler vs Tommy John | Fifth | 30½ out |
| Wednesday, August 5 |
| » Defeated Brewers (40-70), 9-3 | Comiskey Park I (19-34) | 40-71 | Won 2 |
| » Starters: Gene Brabender vs Jim Magnuson | Fifth | 29½ out |
| Thursday, August 6 |
| » Defeated Brewers (40-71), 7-3 | Comiskey Park I (20-34) | 41-71 | Won 3 |
| » Starters: Al Downing vs Jerry Janeski | Fourth | 29½ out |
| Friday, August 7 |
| » Lost to Angels (62-48), 6-4 | Comiskey Park I (20-35) | 41-72 | |
| » Starters: Tom Bradley vs Bart Johnson | Fifth | 30½ out |
| Saturday, August 8 |
| » Defeated Angels (62-49), 8-1 | Comiskey Park I (21-35) | 42-72 | |
| » Starters: Rudy May vs Bob Miller | Fifth | 30½ out |
| Sunday, August 9 |
| » Lost to Angels (63-49), 5-0 | Comiskey Park I (21-36) | 42-73 | |
| » Starters: Clyde Wright vs Tommy John | Sixth | 30½ out |
| » Lost to Angels (64-49), 6-3 | Comiskey Park I (21-37) | 42-74 | Lost 2 |
| » Starters: Tom Murphy vs Jerry Crider | Sixth | 30½ out |
| Tuesday, August 11 |
| » Lost to Yankees (62-51), 7-1 | Yankee Stadium (1-3) | 42-75 | Lost 3 |
| » Starters: Jerry Janeski vs Mel Stottlemyre | Sixth | 30 out |
| Wednesday, August 12 |
| » Defeated Yankees (62-52), 5-1 | Yankee Stadium (2-3) | 43-75 | |
| » Starters: Bart Johnson vs Stan Bahnsen | Sixth | 29 out |
| Thursday, August 13 |
| » Lost to Yankees (63-52), 4-3 | Yankee Stadium (2-4) | 43-76 | |
| » Starters: Bob Miller vs Mike McCormick | Sixth | 29 out |
| Friday, August 14 |
| » Lost to Senators (55-62), 6-5 | Robert F. Kennedy Stadium (1-3) | 43-77 | Lost 2 |
| » Starters: Tommy John vs Joe Coleman | Sixth | 29 out |
| Saturday, August 15 |
| » Lost to Senators (56-62), 4-2 | Robert F. Kennedy Stadium (1-4) | 43-78 | Lost 3 |
| » Starters: Barry Moore vs Jackie Brown | Sixth | 28½ out |
| Sunday, August 16 |
| » Lost to Senators (57-62), 2-1 | Robert F. Kennedy Stadium (1-5) | 43-79 | Lost 4 |
| » Starters: Jerry Janeski vs Casey Cox | Sixth | 29½ out |
| Monday, August 17 |
| » Lost to Red Sox (61-57), 7-2 | Fenway Park (1-3) | 43-80 | Lost 5 |
| » Starters: Bart Johnson vs Cal Koonce | Sixth | 30 out |
| Tuesday, August 18 |
| » Lost to Red Sox (62-57), 8-4 | Fenway Park (1-4) | 43-81 | Lost 6 |
| » Starters: Bob Miller vs Vicente Romo | Sixth | 31 out |
| Wednesday, August 19 |
| » Defeated Red Sox (62-58), 13-5 | Fenway Park (2-4) | 44-81 | |
| » Starters: Tommy John vs Ray Culp | Sixth | 31 out |
| Friday, August 21 |
| » Lost to Yankees (68-54), 4-2 | Comiskey Park I (21-38) | 44-82 | |
| » Starters: Steve Kline vs Jerry Janeski | Sixth | 31½ out |
| Saturday, August 22 |
| » Defeated Yankees (68-55), 3-2 | Comiskey Park I (22-38) | 45-82 | |
| » Starters: Stan Bahnsen vs Bart Johnson | Sixth | 30½ out |
| Sunday, August 23 |
| » Defeated Yankees (68-56), 2-0 | Comiskey Park I (23-38) | 46-82 | Won 2 |
| » Starters: Fritz Peterson vs Tommy John | Sixth | 30 out |
| » Lost to Yankees (69-56), 7-5 | Comiskey Park I (23-39) | 46-83 | |
| » Starters: Mike Kekich vs Bob Miller | Sixth | 30 out |
| Tuesday, August 25 |
| » Defeated Senators (60-66), 4-3 | Comiskey Park I (24-39) | 47-83 | |
| » Starters: Joe Coleman vs Barry Moore | Sixth | 29 out |
| Wednesday, August 26 |
| » Defeated Senators (60-67), 3-1 | Comiskey Park I (25-39) | 48-83 | Won 2 |
| » Starters: Casey Cox vs Jerry Janeski | Sixth | 29 out |
| Friday, August 28 |
| » Lost to Red Sox (65-62), 5-4 | Comiskey Park I (25-40) | 48-84 | |
| » Starters: Gary Peters vs Tommy John | Sixth | 29 out |
| Saturday, August 29 |
| » Defeated Red Sox (65-63), 13-9 | Comiskey Park I (26-40) | 49-84 | |
| » Starters: Cal Koonce vs Bart Johnson | Sixth | 29 out |
| Sunday, August 30 |
| » Lost to Red Sox (66-63), 21-11 | Comiskey Park I (26-41) | 49-85 | |
| » Starters: Vicente Romo vs Jerry Janeski | Sixth | 29½ out |
| » Lost to Red Sox (67-63), 4-1 | Comiskey Park I (26-42) | 49-86 | Lost 2 |
| » Starters: Mike Nagy vs Jim Magnuson | Sixth | 29½ out |
| Tuesday, September 1 |
| » Lost to Athletics (71-62), 6-5 | Oakland-Alameda County Stadium (2-5) | 49-87 | Lost 3 |
| » Starters: Tommy John vs Chuck Dobson | Sixth | 31 out |
| Wednesday, September 2 |
| » Lost to Athletics (72-62), 2-1 | Oakland-Alameda County Stadium (2-6) | 49-88 | Lost 4 |
| » Manager: Bill Adair |
| » Starters: Bart Johnson vs Blue Moon Odom | Sixth | 31½ out |
| Thursday, September 3 |
| » Lost to Athletics (73-62), 4-3 | Oakland-Alameda County Stadium (2-7) | 49-89 | Lost 5 |
| » Starters: Jerry Crider vs Diego Segui | Sixth | 31½ out |
| Future White Sox Craig Wilson is born in Chicago, IL. |
| Friday, September 4 |
| » Lost to Brewers (52-85), 3-2 | County Stadium (3-5) | 49-90 | Lost 6 |
| » Starters: Jerry Janeski vs Skip Lockwood | Sixth | 32½ out |
| Monday, September 7 |
| » Lost to Athletics (77-62), 7-4 | Comiskey Park I (26-43) | 49-91 | Lost 7 |
| » Starters: Vida Blue vs Tommy John | Sixth | 35½ out |
| » Lost to Athletics (78-62), 7-5 | Comiskey Park I (26-44) | 49-92 | Lost 8 |
| » Starters: Diego Segui vs Bart Johnson | Sixth | 35½ out |
| Former White Sox Gene Ford dies in Emmetsburg, IA at the age of 59. |
| Wednesday, September 9 |
| » Defeated Angels (76-65), 11-4 | Comiskey Park I (27-44) | 50-92 | |
| » Starters: Tom Murphy vs Jerry Janeski | Sixth | 34½ out |
| » Defeated Angels (76-66), 3-1 | Comiskey Park I (28-44) | 51-92 | Won 2 |
| » Starters: Clyde Wright vs Billy Wynne | Sixth | 34½ out |
| Friday, September 11 |
| » Lost to Twins (87-56), 6-0 | Metropolitan Stadium (2-5) | 51-93 | |
| » Starters: Barry Moore vs Bill Zepp | Sixth | 36½ out |
| Saturday, September 12 |
| » Defeated Twins (87-57), 5-3 | Metropolitan Stadium (3-5) | 52-93 | |
| » Starters: Bart Johnson vs Bert Blyleven | Sixth | 35½ out |
| Sunday, September 13 |
| » Defeated Twins (87-58), 8-7 | Metropolitan Stadium (4-5) | 53-93 | Won 2 |
| » Starters: Billy Wynne vs Jim Perry | Sixth | 34½ out |
| Friday, September 18 |
| » Lost to Twins (90-60), 5-4 | Comiskey Park I (28-45) | 53-94 | |
| » Manager: Chuck Tanner |
| » Starters: Bill Zepp vs Bart Johnson | Sixth | 35½ out |
| Saturday, September 19 |
| » Lost to Twins (91-60), 5-3 | Comiskey Park I (28-46) | 53-95 | Lost 2 |
| » Starters: Tom Hall vs Tommy John | Sixth | 36½ out |
| Former White Sox Dave Danforth dies in Baltimore, MD at the age of 81. |
| Sunday, September 20 |
| » Lost to Twins (92-60), 8-1 | Comiskey Park I (28-47) | 53-96 | Lost 3 |
| » Starters: Bert Blyleven vs Jerry Janeski | Sixth | 37½ out |
| Future White Sox Chris Snopek is born in Cynthiana, KY. |
| Monday, September 21 |
| » Defeated Royals (59-92), 8-4 | Comiskey Park I (29-47) | 54-96 | |
| » Starters: Jim Rooker vs Joe Horlen | Sixth | 37 out |
| » Lost to Royals (60-92), 8-2 | Comiskey Park I (29-48) | 54-97 | |
| » Starters: Bill Butler vs Floyd Weaver | Sixth | 37 out |
| » Major-league debuts: Art Kusnyer (White Sox) Jim York (Royals) |
| Former White Sox Biggs Wehde dies in Sioux Falls, SD at the age of 64. |
| Tuesday, September 22 |
| » Lost to Royals (61-92), 2-1 | Comiskey Park I (29-49) | 54-98 | Lost 2 |
| » Starters: Dick Drago vs Billy Wynne | Sixth | 38½ out |
| » Lost to Royals (62-92), 6-2 | Comiskey Park I (29-50) | 54-99 | Lost 3 |
| » Starters: Al Fitzmorris vs Jim Magnuson | Sixth | 38½ out |
| Wednesday, September 23 |
| » Defeated Royals (62-93), 6-0 | Comiskey Park I (30-50) | 55-99 | |
| » Starters: Paul Splittorff vs Bart Johnson | Sixth | 38½ out |
| » Major-league debuts: Paul Splittorff |