| Wednesday, January 21 |
| Future Tiger Jeff McCurry is born in Tokyo, Japan. |
| Thursday, February 5 |
| Former Tiger Rudy York dies in Rome, GA at the age of 57. |
| Monday, February 16 |
| Former Tiger Dick Conger dies in Los Angeles, CA at the age of 49. |
| Friday, March 20 |
| Future Tiger Will Brunson is born in Irving, TX. |
| Monday, April 6 |
| » Defeated Senators (0-1), 5-0 | Robert F. Kennedy Stadium (1-0) | 1-0 | |
| » Starters: Mickey Lolich vs Dick Bosman | First | -- |
| » Major-league debuts: Dick Such (Senators) |
| Tuesday, April 7 |
| » Lost to Senators (1-1), 14-4 | Robert F. Kennedy Stadium (1-1) | 1-1 | |
| » Starters: Earl Wilson vs Casey Cox | Second | ½ out |
| » Major-league debuts: Elliott Maddox (Tigers) |
| Wednesday, April 8 |
| » Defeated Senators (1-2), 3-0 | Robert F. Kennedy Stadium (2-1) | 2-1 | |
| » Starters: Joe Niekro vs George Brunet | Third | ½ out |
| Friday, April 10 |
| » Lost to Orioles (4-0), 3-2 | Memorial Stadium (0-1) | 2-2 | |
| » Starters: Mickey Lolich vs Jim Palmer | Fourth | 2 out |
| Saturday, April 11 |
| » Lost to Orioles (5-0), 5-3 | Memorial Stadium (0-2) | 2-3 | Lost 2 |
| » Starters: Earl Wilson vs Dave McNally | Third | 3 out |
| Future Tiger Sean Bergman is born in Joliet, IL. Former Tiger Sailor Stroud dies in Stockton, CA at the age of 85 |
| Sunday, April 12 |
| » Defeated Orioles (5-1), 7-2 | Memorial Stadium (1-2) | 3-3 | |
| » Starters: Joe Niekro vs Mike Cuellar | Second | 2 out |
| Monday, April 13 |
| » Major-league debuts: Jim Johnson (Giants) |
| Tuesday, April 14 |
| » Defeated Indians (2-5), 12-4 | Tiger Stadium (1-0) | 4-3 | Won 2 |
| » Starters: Rich Hand vs Mickey Lolich | Second | 1½ out |
| Thursday, April 16 |
| » Defeated Indians (2-6), 4-2 | Tiger Stadium (2-0) | 5-3 | Won 3 |
| » Starters: Dean Chance vs Earl Wilson | Second | ½ out |
| Former Tiger Mal Eason dies in Douglas, AZ at the age of 92. |
| Friday, April 17 |
| » Defeated Red Sox (5-4), 3-2 | Tiger Stadium (3-0) | 6-3 | Won 4 |
| » Starters: Gary Peters vs Mickey Lolich | First | -- |
| Former Tiger Dick Brown dies in Baltimore, MD at the age of 36. |
| Saturday, April 18 |
| » Defeated Red Sox (5-5), 5-1 | Tiger Stadium (4-0) | 7-3 | Won 5 |
| » Starters: Bill Lee vs Joe Niekro | First | -- |
| Future Tiger Rico Brogna is born in Turners Falls, MA. |
| Tuesday, April 21 |
| » Defeated Indians (3-7), 5-3 | Cleveland Stadium (1-0) | 8-3 | Won 6 |
| » Starters: Earl Wilson vs Dean Chance | First | -- |
| Wednesday, April 22 |
| » Defeated Indians (3-8), 5-0 | Cleveland Stadium (2-0) | 9-3 | Won 7 |
| » Starters: Mickey Lolich vs Sam McDowell | First | -- |
| Friday, April 24 |
| » Defeated Twins (8-4), 8-6 | Metropolitan Stadium (1-0) | 10-3 | Won 8 |
| » Starters: Joe Niekro vs Jim Perry | First | -- |
| Saturday, April 25 |
| » Lost to Twins (9-4), 4-3 | Metropolitan Stadium (1-1) | 10-4 | |
| » Starters: Earl Wilson vs Jim Kaat | First | -- |
| Sunday, April 26 |
| » Lost to Twins (10-4), 6-0 | Metropolitan Stadium (1-2) | 10-5 | Lost 2 |
| » Starters: Mickey Lolich vs Luis Tiant | Second | ½ out |
| Tuesday, April 28 |
| » Defeated Royals (6-11), 8-3 | Municipal Stadium (1-0) | 11-5 | |
| » Starters: Joe Niekro vs Wally Bunker | Second | ½ out |
| Wednesday, April 29 |
| » Defeated Royals (6-12), 8-2 | Municipal Stadium (2-0) | 12-5 | Won 2 |
| » Starters: Mike Kilkenny vs Dick Drago | Second | ½ out |
| Thursday, April 30 |
| » Lost to Royals (7-12), 3-2 | Municipal Stadium (2-1) | 12-6 | |
| » Starters: Mickey Lolich vs Bill Butler | Second | ½ out |
| Former Tiger Chick Gagnon dies in Wilmington, DE at the age of 73. |
| Friday, May 1 |
| » Lost to White Sox (8-12), 13-6 | Comiskey Park I (0-1) | 12-7 | Lost 2 |
| » Starters: Les Cain vs Joe Horlen | Second | 1½ out |
| Saturday, May 2 |
| » Lost to White Sox (9-12), 3-2 | Comiskey Park I (0-2) | 12-8 | Lost 3 |
| » Starters: Joe Niekro vs Jerry Janeski | Second | 1½ out |
| Sunday, May 3 |
| » Defeated White Sox (9-13), 6-5 | Comiskey Park I (1-2) | 13-8 | |
| » Starters: Mike Kilkenny vs Billy Wynne | Second | ½ out |
| Tuesday, May 5 |
| » Lost to Twins (15-7), 8-5 | Tiger Stadium (4-1) | 13-9 | |
| » Starters: Luis Tiant vs Mickey Lolich | Second | 1½ out |
| Wednesday, May 6 |
| » Defeated Twins (15-8), 5-2 | Tiger Stadium (5-1) | 14-9 | |
| » Starters: Dave Boswell vs Les Cain | Second | 1½ out |
| Thursday, May 7 |
| » Lost to Twins (16-8), 9-6 | Tiger Stadium (5-2) | 14-10 | |
| » Starters: Jim Perry vs Joe Niekro | Second | 2½ out |
| Friday, May 8 |
| » Lost to Royals (9-17), 9-3 | Tiger Stadium (5-3) | 14-11 | Lost 2 |
| » Starters: Bob Johnson vs Mike Kilkenny | Second | 3½ out |
| Saturday, May 9 |
| » Defeated Royals (9-18), 7-4 | Tiger Stadium (6-3) | 15-11 | |
| » Starters: Jim Rooker vs Mickey Lolich | Second | 3½ out |
| Sunday, May 10 |
| » Lost to Royals (10-18), 9-7 | Tiger Stadium (6-4) | 15-12 | |
| » Starters: Dick Drago vs Earl Wilson | Second | 5 out |
| Monday, May 11 |
| » Lost to White Sox (12-17), 9-5 | Tiger Stadium (6-5) | 15-13 | Lost 2 |
| » Starters: Billy Wynne vs Joe Niekro | Second | 5½ out |
| Tuesday, May 12 |
| » Lost to White Sox (13-17), 7-2 | Tiger Stadium (6-6) | 15-14 | Lost 3 |
| » Starters: Jerry Janeski vs Les Cain | Third | 6½ out |
| Friday, May 15 |
| » Lost to Yankees (18-16), 4-1 | Yankee Stadium (0-1) | 15-15 | Lost 4 |
| » Starters: Mickey Lolich vs Stan Bahnsen | Third | 7 out |
| Saturday, May 16 |
| » Lost to Yankees (19-16), 7-4 | Yankee Stadium (0-2) | 15-16 | Lost 5 |
| » Starters: Mike Kilkenny vs Mel Stottlemyre | Third | 8 out |
| Tuesday, May 19 |
| » Lost to Red Sox (16-17), 5-4 | Fenway Park (0-1) | 15-17 | Lost 6 |
| » Starters: Joe Niekro vs Mike Nagy | Fourth | 8½ out |
| Wednesday, May 20 |
| » Defeated Orioles (25-11), 4-0 | Tiger Stadium (7-6) | 16-17 | |
| » Starters: Tom Phoebus vs Mickey Lolich | Third | 7½ out |
| Thursday, May 21 |
| » Defeated Orioles (25-12), 6-4 | Tiger Stadium (8-6) | 17-17 | Won 2 |
| » Starters: Dave McNally vs Les Cain | Third | 7½ out |
| » Lost to Orioles (26-12), 3-1 | Tiger Stadium (8-7) | 17-18 | |
| » Starters: Mike Cuellar vs Earl Wilson | Third | 7½ out |
| Future Tiger Bryce Florie is born in Charleston, SC. |
| Friday, May 22 |
| » Defeated Senators (16-22), 3-2 | Tiger Stadium (9-7) | 18-18 | |
| » Starters: Jim Hannan vs Joe Niekro | Third | 7½ out |
| Saturday, May 23 |
| » Lost to Senators (17-22), 6-5 | Tiger Stadium (9-8) | 18-19 | |
| » Starters: George Brunet vs Mike Kilkenny | Third | 8½ out |
| Sunday, May 24 |
| » Lost to Senators (18-22), 6-4 | Tiger Stadium (9-9) | 18-20 | Lost 2 |
| » Starters: Joe Coleman vs Mickey Lolich | Third | 9 out |
| Monday, May 25 |
| » Defeated Yankees (24-20), 4-3 | Tiger Stadium (10-9) | 19-20 | |
| » Starters: Stan Bahnsen vs Les Cain | Third | 9 out |
| Future Tiger Joey Eischen is born in West Covina, CA. |
| Tuesday, May 26 |
| » Defeated Yankees (24-21), 3-0 | Tiger Stadium (11-9) | 20-20 | Won 2 |
| » Starters: Mel Stottlemyre vs Earl Wilson | Third | 9 out |
| Wednesday, May 27 |
| » Lost to Yankees (25-21), 4-2 | Tiger Stadium (11-10) | 20-21 | |
| » Starters: Fritz Peterson vs Joe Niekro | Third | 10 out |
| Friday, May 29 |
| » Defeated Brewers (13-30), 5-4 | County Stadium (1-0) | 21-21 | |
| » Starters: Mickey Lolich vs Skip Lockwood | Third | 10 out |
| Saturday, May 30 |
| » Lost to Brewers (14-30), 9-7 | County Stadium (1-1) | 21-22 | |
| » Starters: Les Cain vs Lew Krausse | Fourth | 10 out |
| Sunday, May 31 |
| » Lost to Brewers (15-30), 7-6 | County Stadium (1-2) | 21-23 | Lost 2 |
| » Starters: Earl Wilson vs Bobby Bolin | Fourth | 10 out |
| Tuesday, June 2 |
| » Lost to Angels (31-17), 3-2 | Anaheim Stadium (0-1) | 21-24 | Lost 3 |
| » Starters: Joe Niekro vs Rudy May | Fourth | 11 out |
| Wednesday, June 3 |
| » Defeated Angels (31-18), 5-4 | Anaheim Stadium (1-1) | 22-24 | |
| » Starters: Mickey Lolich vs Andy Messersmith | Fourth | 10 out |
| Thursday, June 4 |
| » Defeated Angels (31-19), 4-2 | Anaheim Stadium (2-1) | 23-24 | Won 2 |
| » Starters: Les Cain vs Tom Murphy | Fourth | 9 out |
| Friday, June 5 |
| » Lost to Athletics (28-24), 4-2 | Oakland-Alameda County Stadium (0-1) | 23-25 | |
| » Starters: Earl Wilson vs Blue Moon Odom | Fourth | 10 out |
| Saturday, June 6 |
| » Defeated Athletics (28-25), 6-4 | Oakland-Alameda County Stadium (1-1) | 24-25 | |
| » Starters: Joe Niekro vs Chuck Dobson | Third | 9 out |
| Sunday, June 7 |
| » Lost to Athletics (29-25), 5-2 | Oakland-Alameda County Stadium (1-2) | 24-26 | |
| » Starters: Mickey Lolich vs Rollie Fingers | Fourth | 10 out |
| Tuesday, June 9 |
| » Defeated Brewers (17-37), 8-3 | Tiger Stadium (12-10) | 25-26 | |
| » Starters: Ray Peters vs Les Cain | Third | 9 out |
| Wednesday, June 10 |
| » Defeated Brewers (17-38), 7-5 | Tiger Stadium (13-10) | 26-26 | Won 2 |
| » Starters: Bobby Bolin vs Earl Wilson | Third | 9 out |
| Thursday, June 11 |
| » Defeated Brewers (17-39), 6-2 | Tiger Stadium (14-10) | 27-26 | Won 3 |
| » Starters: Gene Brabender vs Joe Niekro | Third | 9 out |
| Friday, June 12 |
| » Lost to Angels (35-22), 5-2 | Tiger Stadium (14-11) | 27-27 | |
| » Starters: Andy Messersmith vs John Hiller | Third | 9 out |
| Saturday, June 13 |
| » Defeated Angels (35-23), 6-5 | Tiger Stadium (15-11) | 28-27 | |
| » Starters: Tom Murphy vs Les Cain | Third | 8 out |
| Sunday, June 14 |
| » Defeated Angels (35-24), 8-4 | Tiger Stadium (16-11) | 29-27 | Won 2 |
| » Starters: Clyde Wright vs Earl Wilson | Third | 8 out |
| Monday, June 15 |
| » Lost to Athletics (34-27), 12-7 | Tiger Stadium (16-12) | 29-28 | |
| » Starters: Chuck Dobson vs Joe Niekro | Third | 8 out |
| Tuesday, June 16 |
| » Defeated Athletics (34-28), 5-1 | Tiger Stadium (17-12) | 30-28 | |
| » Starters: Rollie Fingers vs Mike Kilkenny | Third | 7½ out |
| Wednesday, June 17 |
| » Defeated Athletics (34-29), 9-7 | Tiger Stadium (18-12) | 31-28 | Won 2 |
| » Starters: Catfish Hunter vs Les Cain | Third | 6½ out |
| Friday, June 19 |
| » Lost to Indians (28-32), 4-2 | Cleveland Stadium (2-1) | 31-29 | |
| » Starters: Mickey Lolich vs Sam McDowell | Third | 8 out |
| Saturday, June 20 |
| » Lost to Indians (29-32), 2-1 | Cleveland Stadium (2-2) | 31-30 | Lost 2 |
| » Starters: Earl Wilson vs Steve Dunning | Third | 9 out |
| Sunday, June 21 |
| » Defeated Indians (29-33), 7-2 | Cleveland Stadium (3-2) | 32-30 | |
| » Starters: Les Cain vs Rich Hand | Third | 8½ out |
| » Defeated Indians (29-34), 9-8 | Cleveland Stadium (4-2) | 33-30 | Won 2 |
| » Starters: Mike Kilkenny vs Rick Austin | Third | 8½ out |
| » Major-league debuts: Rick Austin (Indians) |
| Tuesday, June 23 |
| » Lost to Senators (30-37), 6-2 | Robert F. Kennedy Stadium (2-2) | 33-31 | |
| » Starters: Mickey Lolich vs George Brunet | Third | 9 out |
| Wednesday, June 24 |
| » Defeated Senators (30-38), 3-2 | Robert F. Kennedy Stadium (3-2) | 34-31 | |
| » Starters: Earl Wilson vs Casey Cox | Third | 8 out |
| Thursday, June 25 |
| » Defeated Senators (30-39), 2-1 | Robert F. Kennedy Stadium (4-2) | 35-31 | Won 2 |
| » Starters: Les Cain vs Dick Bosman | Third | 8 out |
| Friday, June 26 |
| » Defeated Indians (30-37), 7-1 | Tiger Stadium (19-12) | 36-31 | Won 3 |
| » Starters: Rich Hand vs Joe Niekro | Third | 8 out |
| Saturday, June 27 |
| » Lost to Indians (31-37), 3-0 | Tiger Stadium (19-13) | 36-32 | |
| » Starters: Rick Austin vs Mickey Lolich | Third | 8 out |
| Sunday, June 28 |
| » Lost to Indians (32-37), 8-2 | Tiger Stadium (19-14) | 36-33 | Lost 2 |
| » Starters: Sam McDowell vs Earl Wilson | Third | 7½ out |
| » Defeated Indians (32-38), 5-1 | Tiger Stadium (20-14) | 37-33 | |
| » Starters: Mike Paul vs Mike Kilkenny | Third | 7½ out |
| Monday, June 29 |
| » Major-league debuts: Bobby Grich (Orioles) |
| Tuesday, June 30 |
| » Defeated Yankees (43-30), 5-3 | Tiger Stadium (21-14) | 38-33 | Won 2 |
| » Starters: Fritz Peterson vs Les Cain | Third | 7 out |
| Wednesday, July 1 |
| » Defeated Yankees (43-31), 6-5 | Tiger Stadium (22-14) | 39-33 | Won 3 |
| » Starters: Gary Waslewski vs Denny McLain | Third | 7 out |
| Thursday, July 2 |
| » Defeated Yankees (43-32), 5-0 | Tiger Stadium (23-14) | 40-33 | Won 4 |
| » Starters: Mel Stottlemyre vs Joe Niekro | Third | 6 out |
| Friday, July 3 |
| » Lost to Orioles (49-29), 4-0 | Memorial Stadium (1-3) | 40-34 | |
| » Starters: Mickey Lolich vs Mike Cuellar | Third | 7 out |
| Saturday, July 4 |
| » Defeated Orioles (49-30), 6-5 | Memorial Stadium (2-3) | 41-34 | |
| » Starters: Mike Kilkenny vs Dave McNally | Third | 6 out |
| Sunday, July 5 |
| » Lost to Orioles (50-30), 2-0 | Memorial Stadium (2-4) | 41-35 | |
| » Starters: Denny McLain vs Jim Palmer | Third | 7 out |
| Future Tiger Doug Bochtler is born in West Palm Beach, FL. |
| Monday, July 6 |
| » Defeated Red Sox (40-37), 6-3 | Tiger Stadium (24-14) | 42-35 | |
| » Starters: Gary Peters vs Les Cain | Third | 6½ out |
| Tuesday, July 7 |
| » Lost to Red Sox (41-37), 8-4 | Tiger Stadium (24-15) | 42-36 | |
| » Starters: Ray Culp vs Earl Wilson | Third | 7 out |
| » Defeated Red Sox (41-38), 4-3 | Tiger Stadium (25-15) | 43-36 | |
| » Starters: Ken Brett vs Joe Niekro | Third | 7 out |
| Wednesday, July 8 |
| » Defeated Red Sox (41-39), 3-2 | Tiger Stadium (26-15) | 44-36 | Won 2 |
| » Starters: Sonny Siebert vs Mickey Lolich | Second | 7 out |
| Thursday, July 9 |
| » Defeated Red Sox (41-40), 7-3 | Tiger Stadium (27-15) | 45-36 | Won 3 |
| » Starters: Mike Nagy vs Denny McLain | Second | 6 out |
| Friday, July 10 |
| » Defeated Orioles (52-32), 4-2 | Tiger Stadium (28-15) | 46-36 | Won 4 |
| » Starters: Jim Palmer vs Les Cain | Second | 5 out |
| Saturday, July 11 |
| » Lost to Orioles (53-32), 6-5 | Tiger Stadium (28-16) | 46-37 | |
| » Starters: Mike Cuellar vs Joe Niekro | Second | 6 out |
| Sunday, July 12 |
| » Defeated Orioles (53-33), 7-3 | Tiger Stadium (29-16) | 47-37 | |
| » Starters: Dave McNally vs Mickey Lolich | Second | 6 out |
| » Lost to Orioles (54-33), 13-3 | Tiger Stadium (29-17) | 47-38 | |
| » Starters: Tom Phoebus vs Denny McLain | Second | 6 out |
| Thursday, July 16 |
| » Defeated White Sox (31-59), 11-6 | Comiskey Park I (2-2) | 48-38 | |
| » Starters: Les Cain vs Jerry Janeski | Second | 6 out |
| Friday, July 17 |
| » Defeated White Sox (31-60), 4-3 | Comiskey Park I (3-2) | 49-38 | Won 2 |
| » Starters: Denny McLain vs Tommy John | Second | 5 out |
| Saturday, July 18 |
| » Defeated White Sox (31-61), 5-4 | Comiskey Park I (4-2) | 50-38 | Won 3 |
| » Starters: Mickey Lolich vs Jim Magnuson | Second | 4 out |
| Sunday, July 19 |
| » Defeated Royals (33-56), 2-0 | Municipal Stadium (3-1) | 51-38 | Won 4 |
| » Starters: Joe Niekro vs Dick Drago | Second | 3 out |
| » Defeated Royals (33-57), 6-4 | Municipal Stadium (4-1) | 52-38 | Won 5 |
| » Starters: Mike Kilkenny vs Dave Morehead | Second | 3 out |
| Monday, July 20 |
| » Lost to Royals (34-57), 3-0 | Municipal Stadium (4-2) | 52-39 | |
| » Starters: Les Cain vs Jim Rooker | Second | 4 out |
| Tuesday, July 21 |
| » Defeated Twins (57-31), 5-2 | Metropolitan Stadium (2-2) | 53-39 | |
| » Starters: Denny McLain vs Bill Zepp | Second | 4 out |
| Wednesday, July 22 |
| » Lost to Twins (58-31), 2-1 | Metropolitan Stadium (2-3) | 53-40 | |
| » Starters: Mickey Lolich vs Jim Perry | Second | 5 out |
| Thursday, July 23 |
| » Lost to Twins (59-31), 2-1 | Metropolitan Stadium (2-4) | 53-41 | Lost 2 |
| » Starters: Joe Niekro vs Bert Blyleven | Second | 6 out |
| Friday, July 24 |
| » Lost to White Sox (34-65), 5-2 | Tiger Stadium (29-18) | 53-42 | Lost 3 |
| » Starters: Bob Miller vs Les Cain | Second | 5½ out |
| » Defeated White Sox (34-66), 5-4 | Tiger Stadium (30-18) | 54-42 | |
| » Starters: Jerry Janeski vs Mike Kilkenny | Second | 5½ out |
| Saturday, July 25 |
| » Defeated White Sox (34-67), 9-4 | Tiger Stadium (31-18) | 55-42 | Won 2 |
| » Starters: Jerry Crider vs Denny McLain | Second | 5½ out |
| Sunday, July 26 |
| » Lost to White Sox (35-67), 4-0 | Tiger Stadium (31-19) | 55-43 | |
| » Starters: Tommy John vs Mickey Lolich | Second | 6½ out |
| Tuesday, July 28 |
| » Lost to Royals (37-63), 7-6 | Tiger Stadium (31-20) | 55-44 | Lost 2 |
| » Starters: Dick Drago vs Joe Niekro | Second | 7 out |
| » Major-league debuts: Lerrin LaGrow (Tigers) |
| Wednesday, July 29 |
| » Defeated Royals (37-64), 10-3 | Tiger Stadium (32-20) | 56-44 | |
| » Starters: Jim Rooker vs Les Cain | Second | 6 out |
| Thursday, July 30 |
| » Lost to Royals (38-64), 3-2 | Tiger Stadium (32-21) | 56-45 | |
| » Starters: Bob Johnson vs Mike Kilkenny | Second | 6½ out |
| Friday, July 31 |
| » Defeated Twins (62-36), 10-9 | Tiger Stadium (33-21) | 57-45 | |
| » Starters: Bert Blyleven vs Denny McLain | Second | 6½ out |
| Saturday, August 1 |
| » Lost to Twins (63-36), 12-4 | Tiger Stadium (33-22) | 57-46 | |
| » Starters: Jim Kaat vs Mickey Lolich | Second | 7½ out |
| Sunday, August 2 |
| » Lost to Twins (64-36), 4-3 | Tiger Stadium (33-23) | 57-47 | Lost 2 |
| » Starters: Bill Zepp vs Joe Niekro | Second | 8½ out |
| Monday, August 3 |
| » Lost to Senators (48-58), 4-0 | Tiger Stadium (33-24) | 57-48 | Lost 3 |
| » Starters: Dick Bosman vs Mike Kilkenny | Third | 9 out |
| Tuesday, August 4 |
| » Lost to Senators (49-58), 4-1 | Tiger Stadium (33-25) | 57-49 | Lost 4 |
| » Starters: George Brunet vs Denny McLain | Third | 10 out |
| Wednesday, August 5 |
| » Defeated Senators (49-59), 3-1 | Tiger Stadium (34-25) | 58-49 | |
| » Starters: Jim Shellenback vs Mickey Lolich | Third | 10 out |
| Thursday, August 6 |
| » Defeated Yankees (58-49), 2-1 | Yankee Stadium (1-2) | 59-49 | Won 2 |
| » Starters: Mike Kilkenny vs Mel Stottlemyre | Third | 10 out |
| » Lost to Yankees (59-49), 7-5 | Yankee Stadium (1-3) | 59-50 | |
| » Starters: Joe Niekro vs Stan Bahnsen | Third | 10 out |
| Friday, August 7 |
| » Lost to Yankees (60-49), 5-1 | Yankee Stadium (1-4) | 59-51 | Lost 2 |
| » Starters: Les Cain vs Mike McCormick | Third | 10 out |
| Saturday, August 8 |
| » Defeated Red Sox (54-54), 6-5 | Fenway Park (1-1) | 60-51 | |
| » Starters: Denny McLain vs Vicente Romo | Third | 10 out |
| Sunday, August 9 |
| » Lost to Red Sox (55-54), 7-4 | Fenway Park (1-2) | 60-52 | |
| » Starters: Mickey Lolich vs Ray Culp | Third | 10½ out |
| Monday, August 10 |
| » Lost to Red Sox (56-54), 11-10 | Fenway Park (1-3) | 60-53 | Lost 2 |
| » Starters: Joe Niekro vs Sonny Siebert | Third | 11 out |
| Tuesday, August 11 |
| » Defeated Brewers (42-74), 2-1 | County Stadium (2-2) | 61-53 | |
| » Starters: Mike Kilkenny vs Al Downing | Third | 11 out |
| Wednesday, August 12 |
| » Lost to Brewers (43-74), 6-5 | County Stadium (2-3) | 61-54 | |
| » Starters: Les Cain vs Lew Krausse | Third | 12 out |
| Thursday, August 13 |
| » Lost to Brewers (44-74), 3-2 | County Stadium (2-4) | 61-55 | Lost 2 |
| » Starters: Denny McLain vs Marty Pattin | Third | 12 out |
| Future Tiger Eddie Gaillard is born in Camden, NJ. |
| Friday, August 14 |
| » Lost to Angels (66-51), 7-3 | Anaheim Stadium (2-2) | 61-56 | Lost 3 |
| » Starters: Mickey Lolich vs Clyde Wright | Third | 12 out |
| Saturday, August 15 |
| » Defeated Angels (66-52), 5-1 | Anaheim Stadium (3-2) | 62-56 | |
| » Starters: Joe Niekro vs Lloyd Allen | Third | 12 out |
| Sunday, August 16 |
| » Defeated Angels (66-53), 7-1 | Anaheim Stadium (4-2) | 63-56 | Won 2 |
| » Starters: Les Cain vs Rudy May | Third | 12 out |
| Monday, August 17 |
| » Defeated Athletics (67-54), 5-3 | Oakland-Alameda County Stadium (2-2) | 64-56 | Won 3 |
| » Starters: Denny McLain vs Blue Moon Odom | Third | 12 out |
| Tuesday, August 18 |
| » Defeated Athletics (67-55), 3-1 | Oakland-Alameda County Stadium (3-2) | 65-56 | Won 4 |
| » Starters: Mickey Lolich vs Chuck Dobson | Third | 12 out |
| Future Tiger Bobby Higginson is born in Philadelphia, PA. |
| Wednesday, August 19 |
| » Lost to Athletics (68-55), 7-0 | Oakland-Alameda County Stadium (3-3) | 65-57 | |
| » Starters: Mike Kilkenny vs Diego Segui | Third | 13 out |
| Friday, August 21 |
| » Defeated Brewers (46-78), 6-4 | Tiger Stadium (35-25) | 66-57 | |
| » Starters: Al Downing vs Les Cain | Third | 13 out |
| Saturday, August 22 |
| » Defeated Brewers (46-79), 5-2 | Tiger Stadium (36-25) | 67-57 | Won 2 |
| » Starters: Lew Krausse vs Denny McLain | Third | 12 out |
| Sunday, August 23 |
| » Defeated Brewers (46-80), 1-0 | Tiger Stadium (37-25) | 68-57 | Won 3 |
| » Starters: Marty Pattin vs Mickey Lolich | Third | 12 out |
| Tuesday, August 25 |
| » Lost to Angels (70-56), 6-4 | Tiger Stadium (37-26) | 68-58 | |
| » Starters: Tom Murphy vs Les Cain | Third | 13½ out |
| » Lost to Angels (71-56), 10-6 | Tiger Stadium (37-27) | 68-59 | Lost 2 |
| » Starters: Tom Bradley vs Joe Niekro | Third | 13½ out |
| Wednesday, August 26 |
| » Lost to Angels (72-56), 6-3 | Tiger Stadium (37-28) | 68-60 | Lost 3 |
| » Starters: Clyde Wright vs Denny McLain | Third | 14½ out |
| Friday, August 28 |
| » Lost to Athletics (69-61), 6-2 | Tiger Stadium (37-29) | 68-61 | Lost 4 |
| » Starters: Blue Moon Odom vs Mickey Lolich | Third | 15½ out |
| Saturday, August 29 |
| » Lost to Athletics (70-61), 5-2 | Tiger Stadium (37-30) | 68-62 | Lost 5 |
| » Starters: Diego Segui vs Les Cain | Third | 16½ out |
| Sunday, August 30 |
| » Defeated Athletics (70-62), 6-5 | Tiger Stadium (38-30) | 69-62 | |
| » Starters: Catfish Hunter vs Joe Niekro | Third | 15½ out |
| Monday, August 31 |
| » Lost to Red Sox (68-63), 4-2 | Fenway Park (1-4) | 69-63 | |
| » Starters: Mickey Lolich vs Ray Culp | Third | 16½ out |
| Tuesday, September 1 |
| » Defeated Red Sox (68-64), 10-9 | Fenway Park (2-4) | 70-63 | |
| » Starters: Mike Kilkenny vs Sonny Siebert | Third | 15½ out |
| Wednesday, September 2 |
| » Defeated Red Sox (68-65), 6-4 | Fenway Park (3-4) | 71-63 | Won 2 |
| » Starters: Bob Reed vs Gary Peters | Third | 15 out |
| » Lost to Red Sox (69-65), 10-1 | Fenway Park (3-5) | 71-64 | |
| » Starters: Les Cain vs Cal Koonce | Third | 15 out |
| » Major-league debuts: Gene Lamont (Tigers) |
| Thursday, September 3 |
| » Lost to Red Sox (70-65), 5-2 | Fenway Park (3-6) | 71-65 | Lost 2 |
| » Starters: Joe Niekro vs Ken Brett | Third | 16 out |
| Friday, September 4 |
| » Defeated Senators (64-72), 6-3 | Robert F. Kennedy Stadium (5-2) | 72-65 | |
| » Starters: Mickey Lolich vs Joe Coleman | Third | 16 out |
| Saturday, September 5 |
| » Lost to Senators (65-72), 3-2 | Robert F. Kennedy Stadium (5-3) | 72-66 | |
| » Starters: Mike Kilkenny vs Casey Cox | Third | 17 out |
| Sunday, September 6 |
| » Defeated Senators (65-73), 8-7 | Robert F. Kennedy Stadium (6-3) | 73-66 | |
| » Starters: Les Cain vs Jackie Brown | Third | 16 out |
| Monday, September 7 |
| » Defeated Orioles (89-51), 5-2 | Tiger Stadium (39-30) | 74-66 | Won 2 |
| » Starters: Jim Palmer vs Joe Niekro | Third | 15 out |
| Tuesday, September 8 |
| » Lost to Orioles (90-51), 6-3 | Tiger Stadium (39-31) | 74-67 | |
| » Starters: Marcelino Lopez vs Mickey Lolich | Third | 16 out |
| » Major-league debuts: Tim Hosley (Tigers) |
| Wednesday, September 9 |
| » Lost to Red Sox (74-68), 4-1 | Tiger Stadium (39-32) | 74-68 | Lost 2 |
| » Starters: Mike Nagy vs Mike Kilkenny | Third | 17 out |
| Future Tiger Dan Miceli is born in Newark, NJ. |
| Thursday, September 10 |
| » Lost to Red Sox (75-68), 14-0 | Tiger Stadium (39-33) | 74-69 | Lost 3 |
| » Starters: Ray Culp vs Les Cain | Fourth | 18 out |
| Friday, September 11 |
| » Lost to Senators (67-76), 4-2 | Tiger Stadium (39-34) | 74-70 | Lost 4 |
| » Starters: Bill Gogolewski vs Joe Niekro | Fourth | 19 out |
| Saturday, September 12 |
| » Defeated Senators (67-77), 6-4 | Tiger Stadium (40-34) | 75-70 | |
| » Starters: Dick Bosman vs Mickey Lolich | Third | 19 out |
| Sunday, September 13 |
| » Lost to Senators (68-77), 10-0 | Tiger Stadium (40-35) | 75-71 | |
| » Starters: Joe Coleman vs Mike Kilkenny | Third | 20 out |
| Tuesday, September 15 |
| » Lost to Indians (72-76), 4-3 | Cleveland Stadium (4-3) | 75-72 | Lost 2 |
| » Starters: Les Cain vs Rich Hand | Third | 21 out |
| Wednesday, September 16 |
| » Defeated Indians (72-77), 6-3 | Cleveland Stadium (5-3) | 76-72 | |
| » Starters: Mickey Lolich vs Mike Paul | Third | 20 out |
| Thursday, September 17 |
| » Lost to Indians (73-77), 6-2 | Cleveland Stadium (5-4) | 76-73 | |
| » Starters: Joe Niekro vs Sam McDowell | Fourth | 20 out |
| Friday, September 18 |
| » Lost to Yankees (84-67), 5-0 | Tiger Stadium (40-36) | 76-74 | Lost 2 |
| » Starters: Ron Klimkowski vs Mike Kilkenny | Fourth | 21 out |
| Saturday, September 19 |
| » Lost to Yankees (85-67), 7-6 | Tiger Stadium (40-37) | 76-75 | Lost 3 |
| » Starters: Stan Bahnsen vs John Hiller | Fourth | 21 out |
| Sunday, September 20 |
| » Lost to Yankees (86-67), 5-1 | Tiger Stadium (40-38) | 76-76 | Lost 4 |
| » Starters: Steve Kline vs Mickey Lolich | Fourth | 22 out |
| Monday, September 21 |
| » Lost to Orioles (99-54), 4-3 | Memorial Stadium (2-5) | 76-77 | Lost 5 |
| » Starters: Joe Niekro vs Marcelino Lopez | Fourth | 23 out |
| Tuesday, September 22 |
| » Lost to Orioles (100-54), 10-2 | Memorial Stadium (2-6) | 76-78 | Lost 6 |
| » Starters: Bob Reed vs Tom Phoebus | Fourth | 24 out |
