| Monday, January 19 |
| Future Oriole Rick Krivda is born in McKeesport, PA. |
| Friday, January 23 |
| Future Oriole Sherman Obando is born in Bocas Del Toro, Panama. |
| Saturday, January 31 |
| Future Oriole Joel Bennett is born in Waukegan, IL. |
| Monday, April 6 |
| » Major-league debuts: Dick Such (Senators) |
| Tuesday, April 7 |
| » Defeated Indians (0-1), 8-2 | Cleveland Stadium (1-0) | 1-0 | |
| » Starters: Dave McNally vs Sam McDowell | First | -- |
| » Major-league debuts: Ted Ford and Roy Foster (Indians) |
| Wednesday, April 8 |
| » Defeated Indians (0-2), 3-2 | Cleveland Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Mike Cuellar vs Barry Moore | First | -- |
| Thursday, April 9 |
| » Defeated Indians (0-3), 13-1 | Cleveland Stadium (3-0) | 3-0 | Won 3 |
| » Starters: Tom Phoebus vs Rich Hand | First | -- |
| » Major-league debuts: Rich Hand (Indians) |
| Friday, April 10 |
| » Defeated Tigers (2-2), 3-2 | Memorial Stadium (1-0) | 4-0 | Won 4 |
| » Starters: Mickey Lolich vs Jim Palmer | First | -- |
| Saturday, April 11 |
| » Defeated Tigers (2-3), 5-3 | Memorial Stadium (2-0) | 5-0 | Won 5 |
| » Starters: Earl Wilson vs Dave McNally | First | -- |
| Sunday, April 12 |
| » Lost to Tigers (3-3), 7-2 | Memorial Stadium (2-1) | 5-1 | |
| » Starters: Joe Niekro vs Mike Cuellar | First | -- |
| Thursday, April 16 |
| » Lost to Senators (4-3), 4-2 | Memorial Stadium (2-2) | 5-2 | Lost 2 |
| » Starters: Joe Coleman vs Jim Palmer | First | -- |
| Friday, April 17 |
| » Lost to Yankees (3-6), 4-1 | Memorial Stadium (2-3) | 5-3 | Lost 3 |
| » Starters: Mel Stottlemyre vs Tom Phoebus | Second | ½ out |
| Former Oriole Dick Brown dies in Baltimore, MD at the age of 36. |
| Saturday, April 18 |
| » Defeated Yankees (3-7), 5-4 | Memorial Stadium (3-3) | 6-3 | |
| » Starters: Fritz Peterson vs Dave McNally | Second | ½ out |
| Sunday, April 19 |
| » Defeated Yankees (3-8), 4-3 | Memorial Stadium (4-3) | 7-3 | Won 2 |
| » Starters: Bill Burbach vs Mike Cuellar | Second | ½ out |
| » Lost to Yankees (4-8), 8-5 | Memorial Stadium (4-4) | 7-4 | |
| » Starters: Ron Klimkowski vs Jim Hardin | Second | ½ out |
| Monday, April 20 |
| » Defeated Red Sox (5-6), 3-2 | Fenway Park (1-0) | 8-4 | |
| » Starters: Jim Palmer vs Ray Culp | Second | 1 out |
| Wednesday, April 22 |
| » Lost to Red Sox (6-6), 5-2 | Fenway Park (1-1) | 8-5 | |
| » Starters: Dave McNally vs Jim Lonborg | Second | 1½ out |
| Friday, April 24 |
| » Defeated Royals (6-8), 7-5 | Municipal Stadium (1-0) | 9-5 | |
| » Starters: Mike Cuellar vs Dick Drago | Second | 1½ out |
| Saturday, April 25 |
| » Defeated Royals (6-9), 9-3 | Municipal Stadium (2-0) | 10-5 | Won 2 |
| » Starters: Jim Palmer vs Bill Butler | Second | ½ out |
| Sunday, April 26 |
| » Defeated Royals (6-10), 10-9 | Municipal Stadium (3-0) | 11-5 | Won 3 |
| » Starters: Dave McNally vs Dave Morehead | First | -- |
| Tuesday, April 28 |
| » Defeated White Sox (6-11), 4-2 | Comiskey Park I (1-0) | 12-5 | Won 4 |
| » Starters: Mike Cuellar vs Jerry Janeski | First | -- |
| Wednesday, April 29 |
| » Defeated White Sox (6-12), 18-2 | Comiskey Park I (2-0) | 13-5 | Won 5 |
| » Starters: Jim Palmer vs Tommie Sisk | First | -- |
| Thursday, April 30 |
| » Lost to White Sox (7-12), 6-3 | Comiskey Park I (2-1) | 13-6 | |
| » Starters: Tom Phoebus vs Tommy John | First | -- |
| Friday, May 1 |
| » Defeated Twins (12-7), 9-3 | Memorial Stadium (5-4) | 14-6 | |
| » Starters: Dave Boswell vs Dave McNally | First | -- |
| Saturday, May 2 |
| » Lost to Twins (13-7), 4-2 | Memorial Stadium (5-5) | 14-7 | |
| » Starters: Jim Perry vs Mike Cuellar | First | -- |
| Sunday, May 3 |
| » Lost to Twins (14-7), 4-3 | Memorial Stadium (5-6) | 14-8 | Lost 2 |
| » Starters: Jim Kaat vs Jim Palmer | First | -- |
| Tuesday, May 5 |
| » Defeated Royals (8-15), 7-3 | Memorial Stadium (6-6) | 15-8 | |
| » Starters: Dick Drago vs Tom Phoebus | First | -- |
| Wednesday, May 6 |
| » Defeated Royals (8-16), 3-1 | Memorial Stadium (7-6) | 16-8 | Won 2 |
| » Starters: Bill Butler vs Dave McNally | First | -- |
| Thursday, May 7 |
| » Defeated Royals (8-17), 7-6 | Memorial Stadium (8-6) | 17-8 | Won 3 |
| » Starters: Dave Morehead vs Mike Cuellar | First | -- |
| Future Oriole Brook Fordyce is born in New London, CT. Future Oriole Mark Smith is born in Pasadena, CA. |
| Friday, May 8 |
| » Defeated White Sox (11-14), 6-1 | Memorial Stadium (9-6) | 18-8 | Won 4 |
| » Starters: Jerry Janeski vs Jim Palmer | First | -- |
| Saturday, May 9 |
| » Defeated White Sox (11-15), 4-3 | Memorial Stadium (10-6) | 19-8 | Won 5 |
| » Starters: Tommy John vs Tom Phoebus | First | -- |
| Sunday, May 10 |
| » Defeated White Sox (11-16), 7-2 | Memorial Stadium (11-6) | 20-8 | Won 6 |
| » Starters: Gerry Arrigo vs Dave McNally | First | -- |
| » Defeated White Sox (11-17), 4-2 | Memorial Stadium (12-6) | 21-8 | Won 7 |
| » Starters: Joe Horlen vs Jim Hardin | First | -- |
| Tuesday, May 12 |
| » Defeated Twins (18-10), 5-4 | Metropolitan Stadium (1-0) | 22-8 | Won 8 |
| » Starters: Mike Cuellar vs Jim Perry | First | -- |
| Wednesday, May 13 |
| » Lost to Twins (19-10), 5-4 | Metropolitan Stadium (1-1) | 22-9 | |
| » Starters: Jim Palmer vs Jim Kaat | First | -- |
| Friday, May 15 |
| » Defeated Senators (13-19), 4-3 | Robert F. Kennedy Stadium (1-0) | 23-9 | |
| » Starters: Tom Phoebus vs Dick Bosman | First | -- |
| Saturday, May 16 |
| » Defeated Senators (13-20), 4-3 | Robert F. Kennedy Stadium (2-0) | 24-9 | Won 2 |
| » Starters: Dave McNally vs Casey Cox | First | -- |
| Monday, May 18 |
| » Lost to Yankees (20-16), 10-4 | Yankee Stadium (0-1) | 24-10 | |
| » Starters: Mike Cuellar vs Fritz Peterson | First | -- |
| Tuesday, May 19 |
| » Defeated Yankees (20-17), 5-1 | Yankee Stadium (1-1) | 25-10 | |
| » Starters: Jim Palmer vs John Cumberland | First | -- |
| Wednesday, May 20 |
| » Lost to Tigers (16-17), 4-0 | Tiger Stadium (0-1) | 25-11 | |
| » Starters: Tom Phoebus vs Mickey Lolich | First | -- |
| Thursday, May 21 |
| » Lost to Tigers (17-17), 6-4 | Tiger Stadium (0-2) | 25-12 | Lost 2 |
| » Starters: Dave McNally vs Les Cain | First | -- |
| » Defeated Tigers (17-18), 3-1 | Tiger Stadium (1-2) | 26-12 | |
| » Starters: Mike Cuellar vs Earl Wilson | First | -- |
| Friday, May 22 |
| » Defeated Red Sox (16-20), 7-4 | Memorial Stadium (13-6) | 27-12 | Won 2 |
| » Starters: Gary Peters vs Jim Hardin | First | -- |
| Saturday, May 23 |
| » Defeated Red Sox (16-21), 3-0 | Memorial Stadium (14-6) | 28-12 | Won 3 |
| » Starters: Ray Culp vs Jim Palmer | First | -- |
| Sunday, May 24 |
| » Defeated Red Sox (16-22), 2-1 | Memorial Stadium (15-6) | 29-12 | Won 4 |
| » Starters: Mike Nagy vs Mike Cuellar | First | -- |
| » Lost to Red Sox (17-22), 4-3 | Memorial Stadium (15-7) | 29-13 | |
| » Starters: Sonny Siebert vs Tom Phoebus | First | -- |
| Monday, May 25 |
| » Defeated Indians (14-24), 6-2 | Memorial Stadium (16-7) | 30-13 | |
| » Starters: Bob Miller vs Dave McNally | First | -- |
| Tuesday, May 26 |
| » Defeated Indians (14-25), 7-0 | Memorial Stadium (17-7) | 31-13 | Won 2 |
| » Starters: Dean Chance vs Jim Hardin | First | -- |
| Wednesday, May 27 |
| » Defeated Indians (14-26), 5-4 | Memorial Stadium (18-7) | 32-13 | Won 3 |
| » Starters: Rich Hand vs Jim Palmer | First | -- |
| Friday, May 29 |
| » Defeated Angels (28-17), 2-0 | Anaheim Stadium (1-0) | 33-13 | Won 4 |
| » Starters: Mike Cuellar vs Andy Messersmith | First | -- |
| Saturday, May 30 |
| » Lost to Angels (29-17), 3-2 | Anaheim Stadium (1-1) | 33-14 | |
| » Starters: Tom Phoebus vs Tom Murphy | First | -- |
| Sunday, May 31 |
| » Lost to Angels (30-17), 6-1 | Anaheim Stadium (1-2) | 33-15 | Lost 2 |
| » Starters: Dave McNally vs Clyde Wright | First | -- |
| Tuesday, June 2 |
| » Defeated Athletics (25-24), 5-1 | Oakland-Alameda County Stadium (1-0) | 34-15 | |
| » Starters: Jim Palmer vs Chuck Dobson | First | -- |
| Wednesday, June 3 |
| » Lost to Athletics (26-24), 4-1 | Oakland-Alameda County Stadium (1-1) | 34-16 | |
| » Starters: Mike Cuellar vs Rollie Fingers | First | -- |
| Thursday, June 4 |
| » Lost to Athletics (27-24), 4-2 | Oakland-Alameda County Stadium (1-2) | 34-17 | Lost 2 |
| » Starters: Tom Phoebus vs Catfish Hunter | First | -- |
| Friday, June 5 |
| » Defeated Brewers (15-35), 3-2 | County Stadium (1-0) | 35-17 | |
| » Starters: Dave McNally vs Bobby Bolin | First | -- |
| Saturday, June 6 |
| » Lost to Brewers (16-35), 6-4 | County Stadium (1-1) | 35-18 | |
| » Starters: Jim Palmer vs Gene Brabender | First | -- |
| Sunday, June 7 |
| » Defeated Brewers (16-36), 7-6 | County Stadium (2-1) | 36-18 | |
| » Starters: Mike Cuellar vs Marty Pattin | First | -- |
| Tuesday, June 9 |
| » Lost to Angels (34-20), 7-5 | Memorial Stadium (18-8) | 36-19 | |
| » Starters: Tom Murphy vs Dave McNally | First | -- |
| Wednesday, June 10 |
| » Defeated Angels (34-21), 2-1 | Memorial Stadium (19-8) | 37-19 | |
| » Starters: Clyde Wright vs Jim Palmer | First | -- |
| Thursday, June 11 |
| » Defeated Angels (34-22), 9-1 | Memorial Stadium (20-8) | 38-19 | Won 2 |
| » Starters: Rudy May vs Mike Cuellar | First | -- |
| Friday, June 12 |
| » Lost to Athletics (32-26), 4-2 | Memorial Stadium (20-9) | 38-20 | |
| » Starters: Rollie Fingers vs Tom Phoebus | First | -- |
| Future Oriole Damon Buford is born in Baltimore, MD. |
| Saturday, June 13 |
| » Lost to Athletics (33-26), 10-7 | Memorial Stadium (20-10) | 38-21 | Lost 2 |
| » Starters: Catfish Hunter vs Dave McNally | First | -- |
| Sunday, June 14 |
| » Defeated Athletics (33-27), 4-2 | Memorial Stadium (21-10) | 39-21 | |
| » Starters: Blue Moon Odom vs Jim Palmer | First | -- |
| Monday, June 15 |
| » Lost to Brewers (19-41), 9-6 | Memorial Stadium (21-11) | 39-22 | |
| » Starters: Bobby Bolin vs Mike Cuellar | First | -- |
| Wednesday, June 17 |
| » Lost to Brewers (20-41), 5-1 | Memorial Stadium (21-12) | 39-23 | Lost 2 |
| » Starters: Gene Brabender vs Dave McNally | First | -- |
| Friday, June 19 |
| » Defeated Senators (29-34), 12-10 | Memorial Stadium (22-12) | 40-23 | |
| » Starters: Dick Bosman vs Jim Palmer | First | -- |
| » Defeated Senators (29-35), 3-2 | Memorial Stadium (23-12) | 41-23 | Won 2 |
| » Starters: Casey Cox vs Jim Hardin | First | -- |
| Saturday, June 20 |
| » Defeated Senators (29-36), 5-4 | Memorial Stadium (24-12) | 42-23 | Won 3 |
| » Starters: Joe Coleman vs Mike Cuellar | First | -- |
| Sunday, June 21 |
| » Defeated Senators (29-37), 4-2 | Memorial Stadium (25-12) | 43-23 | Won 4 |
| » Starters: Dick Such vs Dave McNally | First | -- |
| Monday, June 22 |
| » Defeated Red Sox (30-33), 9-8 | Fenway Park (2-1) | 44-23 | Won 5 |
| » Starters: Tom Phoebus vs Ken Brett | First | -- |
| Tuesday, June 23 |
| » Lost to Red Sox (31-33), 5-1 | Fenway Park (2-2) | 44-24 | |
| » Starters: Jim Palmer vs Ray Culp | First | -- |
| Wednesday, June 24 |
| » Lost to Red Sox (32-33), 6-5 | Fenway Park (2-3) | 44-25 | Lost 2 |
| » Starters: Jim Hardin vs Sonny Siebert | First | -- |
| Thursday, June 25 |
| » Defeated Red Sox (32-34), 13-8 | Fenway Park (3-3) | 45-25 | |
| » Starters: Mike Cuellar vs Mike Nagy | First | -- |
| Friday, June 26 |
| » Defeated Senators (30-40), 12-2 | Robert F. Kennedy Stadium (3-0) | 46-25 | Won 2 |
| » Starters: Dave McNally vs Joe Coleman | First | -- |
| Saturday, June 27 |
| » Lost to Senators (31-40), 5-3 | Robert F. Kennedy Stadium (3-1) | 46-26 | |
| » Starters: Jim Palmer vs Dick Such | First | -- |
| Sunday, June 28 |
| » Lost to Senators (32-40), 4-3 | Robert F. Kennedy Stadium (3-2) | 46-27 | Lost 2 |
| » Starters: Jim Hardin vs George Brunet | First | -- |
| Monday, June 29 |
| » Lost to Senators (33-40), 5-3 | Robert F. Kennedy Stadium (3-3) | 46-28 | Lost 3 |
| » Starters: Mike Cuellar vs Casey Cox | First | -- |
| » Major-league debuts: Bobby Grich (Orioles) |
| Tuesday, June 30 |
| » Defeated Indians (32-39), 4-2 | Memorial Stadium (26-12) | 47-28 | |
| » Starters: Steve Dunning vs Dave McNally | First | -- |
| Wednesday, July 1 |
| » Defeated Indians (32-40), 3-0 | Memorial Stadium (27-12) | 48-28 | Won 2 |
| » Starters: Rick Austin vs Jim Palmer | First | -- |
| Thursday, July 2 |
| » Lost to Indians (33-40), 10-9 | Memorial Stadium (27-13) | 48-29 | |
| » Starters: Sam McDowell vs Jim Hardin | First | -- |
| Friday, July 3 |
| » Defeated Tigers (40-34), 4-0 | Memorial Stadium (28-13) | 49-29 | |
| » Starters: Mickey Lolich vs Mike Cuellar | First | -- |
| Saturday, July 4 |
| » Lost to Tigers (41-34), 6-5 | Memorial Stadium (28-14) | 49-30 | |
| » Starters: Mike Kilkenny vs Dave McNally | First | -- |
| Sunday, July 5 |
| » Defeated Tigers (41-35), 2-0 | Memorial Stadium (29-14) | 50-30 | |
| » Starters: Denny McLain vs Jim Palmer | First | -- |
| Tuesday, July 7 |
| » Defeated Yankees (44-36), 6-2 | Memorial Stadium (30-14) | 51-30 | Won 2 |
| » Starters: Mel Stottlemyre vs Mike Cuellar | First | -- |
| Wednesday, July 8 |
| » Defeated Yankees (44-37), 9-8 | Memorial Stadium (31-14) | 52-30 | Won 3 |
| » Starters: Stan Bahnsen vs Dave McNally | First | -- |
| Thursday, July 9 |
| » Lost to Yankees (45-37), 7-5 | Memorial Stadium (31-15) | 52-31 | |
| » Starters: Fritz Peterson vs Jim Hardin | First | -- |
| Friday, July 10 |
| » Lost to Tigers (46-36), 4-2 | Tiger Stadium (1-3) | 52-32 | Lost 2 |
| » Starters: Jim Palmer vs Les Cain | First | -- |
| Saturday, July 11 |
| » Defeated Tigers (46-37), 6-5 | Tiger Stadium (2-3) | 53-32 | |
| » Starters: Mike Cuellar vs Joe Niekro | First | -- |
| Sunday, July 12 |
| » Lost to Tigers (47-37), 7-3 | Tiger Stadium (2-4) | 53-33 | |
| » Starters: Dave McNally vs Mickey Lolich | First | -- |
| » Defeated Tigers (47-38), 13-3 | Tiger Stadium (3-4) | 54-33 | |
| » Starters: Tom Phoebus vs Denny McLain | First | -- |
| Thursday, July 16 |
| » Defeated Twins (54-29), 5-1 | Memorial Stadium (32-15) | 55-33 | Won 2 |
| » Starters: Tom Hall vs Mike Cuellar | First | -- |
| Friday, July 17 |
| » Lost to Twins (55-29), 6-5 | Memorial Stadium (32-16) | 55-34 | |
| » Starters: Bill Zepp vs Jim Hardin | First | -- |
| Saturday, July 18 |
| » Lost to Twins (56-29), 6-3 | Memorial Stadium (32-17) | 55-35 | Lost 2 |
| » Starters: Jim Perry vs Dave McNally | First | -- |
| Sunday, July 19 |
| » Defeated White Sox (31-62), 8-2 | Comiskey Park I (3-1) | 56-35 | |
| » Starters: Jim Palmer vs Joe Horlen | First | -- |
| » Lost to White Sox (32-62), 7-3 | Comiskey Park I (3-2) | 56-36 | |
| » Starters: Tom Phoebus vs Bob Miller | First | -- |
| Monday, July 20 |
| » Defeated White Sox (32-63), 14-5 | Comiskey Park I (4-2) | 57-36 | |
| » Starters: Mike Cuellar vs Jerry Janeski | First | -- |
| Tuesday, July 21 |
| » Defeated Royals (34-58), 2-1 | Municipal Stadium (4-0) | 58-36 | Won 2 |
| » Starters: Jim Hardin vs Bob Johnson | First | -- |
| Wednesday, July 22 |
| » Defeated Royals (34-59), 4-3 | Municipal Stadium (5-0) | 59-36 | Won 3 |
| » Starters: Dave McNally vs Bill Butler | First | -- |
| Thursday, July 23 |
| » Defeated Royals (34-60), 5-4 | Municipal Stadium (6-0) | 60-36 | Won 4 |
| » Starters: Jim Palmer vs Dick Drago | First | -- |
| Friday, July 24 |
| » Lost to Twins (60-31), 8-0 | Metropolitan Stadium (1-2) | 60-37 | |
| » Starters: Mike Cuellar vs Jim Kaat | First | -- |
| Saturday, July 25 |
| » Defeated Twins (60-32), 6-5 | Metropolitan Stadium (2-2) | 61-37 | |
| » Starters: Jim Hardin vs Bill Zepp | First | -- |
| Sunday, July 26 |
| » Defeated Twins (60-33), 11-1 | Metropolitan Stadium (3-2) | 62-37 | Won 2 |
| » Starters: Dave McNally vs Jim Perry | First | -- |
| Monday, July 27 |
| » Lost to Twins (61-33), 5-2 | Metropolitan Stadium (3-3) | 62-38 | |
| » Starters: Jim Palmer vs Bert Blyleven | First | -- |
| Tuesday, July 28 |
| » Defeated White Sox (35-68), 4-2 | Memorial Stadium (33-17) | 63-38 | |
| » Starters: Joe Horlen vs Mike Cuellar | First | -- |
| Wednesday, July 29 |
| » Lost to White Sox (36-68), 2-1 | Memorial Stadium (33-18) | 63-39 | |
| » Starters: Bob Miller vs Jim Hardin | First | -- |
| Friday, July 31 |
| » Defeated Royals (38-65), 3-1 | Memorial Stadium (34-18) | 64-39 | |
| » Starters: Bill Butler vs Dave McNally | First | -- |
| Future Oriole Mike Figga is born in Tampa, FL. |
| Saturday, August 1 |
| » Defeated Royals (38-66), 9-1 | Memorial Stadium (35-18) | 65-39 | Won 2 |
| » Starters: Dick Drago vs Jim Palmer | First | -- |
| Sunday, August 2 |
| » Defeated Royals (38-67), 10-8 | Memorial Stadium (36-18) | 66-39 | Won 3 |
| » Starters: Jim Rooker vs Mike Cuellar | First | -- |
| Tuesday, August 4 |
| » Defeated Red Sox (53-51), 5-2 | Memorial Stadium (37-18) | 67-39 | Won 4 |
| » Starters: Ray Culp vs Dave McNally | First | -- |
| Wednesday, August 5 |
| » Defeated Red Sox (53-52), 3-0 | Memorial Stadium (38-18) | 68-39 | Won 5 |
| » Starters: Sonny Siebert vs Jim Palmer | First | -- |
| Thursday, August 6 |
| » Lost to Indians (53-56), 4-0 | Cleveland Stadium (3-1) | 68-40 | |
| » Starters: Mike Cuellar vs Dean Chance | First | -- |
| » Defeated Indians (53-57), 7-1 | Cleveland Stadium (4-1) | 69-40 | |
| » Starters: Jim Hardin vs Steve Dunning | First | -- |
| Friday, August 7 |
| » Lost to Indians (54-57), 10-4 | Cleveland Stadium (4-2) | 69-41 | |
| » Starters: Tom Phoebus vs Rich Hand | First | -- |
| Saturday, August 8 |
| » Defeated Yankees (60-50), 4-2 | Yankee Stadium (2-1) | 70-41 | |
| » Starters: Dave McNally vs Mike Kekich | First | -- |
| Sunday, August 9 |
| » Lost to Yankees (61-50), 6-4 | Yankee Stadium (2-2) | 70-42 | |
| » Starters: Jim Palmer vs Fritz Peterson | First | -- |
| » Defeated Yankees (61-51), 12-9 | Yankee Stadium (3-2) | 71-42 | |
| » Starters: Marcelino Lopez vs Steve Kline | First | -- |
| » Major-league debuts: Frank Baker (Yankees) |
| Tuesday, August 11 |
| » Defeated Angels (64-50), 7-0 | Anaheim Stadium (2-2) | 72-42 | Won 2 |
| » Starters: Mike Cuellar vs Andy Messersmith | First | -- |
| Wednesday, August 12 |
| » Defeated Angels (64-51), 5-4 | Anaheim Stadium (3-2) | 73-42 | Won 3 |
| » Starters: Dave McNally vs Rudy May | First | -- |
| Thursday, August 13 |
| » Lost to Angels (65-51), 3-2 | Anaheim Stadium (3-3) | 73-43 | |
| » Starters: Jim Palmer vs Tom Murphy | First | -- |
| Friday, August 14 |
| » Lost to Athletics (67-51), 4-0 | Oakland-Alameda County Stadium (1-3) | 73-44 | Lost 2 |
| » Starters: Jim Hardin vs Chuck Dobson | First | -- |
| Saturday, August 15 |
| » Defeated Athletics (67-52), 7-1 | Oakland-Alameda County Stadium (2-3) | 74-44 | |
| » Starters: Mike Cuellar vs Diego Segui | First | -- |
| Sunday, August 16 |
| » Defeated Athletics (67-53), 2-1 | Oakland-Alameda County Stadium (3-3) | 75-44 | Won 2 |
| » Starters: Dave McNally vs Catfish Hunter | First | -- |
| Monday, August 17 |
| » Defeated Brewers (46-75), 3-2 | County Stadium (3-1) | 76-44 | Won 3 |
| » Starters: Jim Palmer vs Lew Krausse | First | -- |
| Tuesday, August 18 |
| » Defeated Brewers (46-76), 3-0 | County Stadium (4-1) | 77-44 | Won 4 |
| » Starters: Jim Hardin vs Marty Pattin | First | -- |
| Wednesday, August 19 |
| » Defeated Brewers (46-77), 3-2 | County Stadium (5-1) | 78-44 | Won 5 |
| » Starters: Mike Cuellar vs Skip Lockwood | First | -- |
| Friday, August 21 |
| » Defeated Angels (68-55), 5-0 | Memorial Stadium (39-18) | 79-44 | Won 6 |
| » Starters: Tom Murphy vs Dave McNally | First | -- |
| Saturday, August 22 |
| » Lost to Angels (69-55), 3-2 | Memorial Stadium (39-19) | 79-45 | |
| » Starters: Clyde Wright vs Jim Palmer | First | -- |
| Sunday, August 23 |
| » Defeated Angels (69-56), 6-5 | Memorial Stadium (40-19) | 80-45 | |
| » Starters: Rudy May vs Mike Cuellar | First | -- |
| Tuesday, August 25 |
| » Defeated Athletics (68-59), 5-1 | Memorial Stadium (41-19) | 81-45 | Won 2 |
| » Starters: Diego Segui vs Dave McNally | First | -- |
| Wednesday, August 26 |
| » Defeated Athletics (68-60), 5-1 | Memorial Stadium (42-19) | 82-45 | Won 3 |
| » Starters: Catfish Hunter vs Jim Palmer | First | -- |
| Thursday, August 27 |
| » Defeated Athletics (68-61), 6-4 | Memorial Stadium (43-19) | 83-45 | Won 4 |
| » Starters: Chuck Dobson vs Mike Cuellar | First | -- |
| Friday, August 28 |
| » Lost to Brewers (49-81), 2-1 | Memorial Stadium (43-20) | 83-46 | |
| » Starters: Marty Pattin vs Jim Hardin | First | -- |
| » Defeated Brewers (49-82), 8-4 | Memorial Stadium (44-20) | 84-46 | |
| » Starters: Gene Brabender vs Tom Phoebus | First | -- |
| Saturday, August 29 |
| » Defeated Brewers (49-83), 6-1 | Memorial Stadium (45-20) | 85-46 | Won 2 |
| » Starters: Bobby Bolin vs Dave McNally | First | -- |
| Sunday, August 30 |
| » Lost to Brewers (50-83), 5-2 | Memorial Stadium (45-21) | 85-47 | |
| » Starters: Skip Lockwood vs Jim Palmer | First | -- |
| Monday, August 31 |
| » Defeated Yankees (74-59), 10-2 | Yankee Stadium (4-2) | 86-47 | |
| » Starters: Mike Cuellar vs Stan Bahnsen | First | -- |
| Tuesday, September 1 |
| » Lost to Yankees (75-59), 4-2 | Yankee Stadium (4-3) | 86-48 | |
| » Starters: Jim Hardin vs Fritz Peterson | First | -- |
| Wednesday, September 2 |
| » Lost to Yankees (76-59), 3-2 | Yankee Stadium (4-4) | 86-49 | Lost 2 |
| » Starters: Dave McNally vs Mike Kekich | First | -- |
| Thursday, September 3 |
| » Defeated Yankees (76-60), 8-4 | Yankee Stadium (5-4) | 87-49 | |
| » Starters: Jim Palmer vs Mel Stottlemyre | First | -- |
| Friday, September 4 |
| » Defeated Red Sox (70-66), 8-6 | Fenway Park (4-3) | 88-49 | Won 2 |
| » Starters: Mike Cuellar vs Mike Nagy | First | -- |
| Saturday, September 5 |
| » Defeated Red Sox (70-67), 3-2 | Fenway Park (5-3) | 89-49 | Won 3 |
| » Starters: Tom Phoebus vs Ray Culp | First | -- |
| Sunday, September 6 |
| » Lost to Red Sox (71-67), 9-8 | Fenway Park (5-4) | 89-50 | |
| » Starters: Dave McNally vs Sonny Siebert | First | -- |
| » Major-league debuts: Bob Montgomery (Red Sox) |
| Monday, September 7 |
| » Lost to Tigers (74-66), 5-2 | Tiger Stadium (3-5) | 89-51 | Lost 2 |
| » Starters: Jim Palmer vs Joe Niekro | First | -- |
| Tuesday, September 8 |
| » Defeated Tigers (74-67), 6-3 | Tiger Stadium (4-5) | 90-51 | |
| » Starters: Marcelino Lopez vs Mickey Lolich | First | -- |
| » Major-league debuts: Tim Hosley (Tigers) |
| Wednesday, September 9 |
| » Defeated Yankees (81-61), 1-0 | Memorial Stadium (46-21) | 91-51 | Won 2 |
| » Starters: Steve Kline vs Mike Cuellar | First | -- |
| Thursday, September 10 |
| » Defeated Yankees (81-62), 2-1 | Memorial Stadium (47-21) | 92-51 | Won 3 |
| » Starters: Stan Bahnsen vs Dave McNally | First | -- |
| Friday, September 11 |
| » Defeated Red Sox (75-69), 3-2 | Memorial Stadium (48-21) | 93-51 | Won 4 |
| » Starters: Sonny Siebert vs Jim Palmer | First | -- |
| Saturday, September 12 |
| » Defeated Red Sox (75-70), 5-1 | Memorial Stadium (49-21) | 94-51 | Won 5 |
| » Starters: Gary Peters vs Tom Phoebus | First | -- |
| Sunday, September 13 |
| » Defeated Red Sox (75-71), 13-2 | Memorial Stadium (50-21) | 95-51 | Won 6 |
| » Starters: Ken Brett vs Mike Cuellar | First | -- |
| » Major-league debuts: Roger Moret (Red Sox) |
| Tuesday, September 15 |
| » Defeated Senators (68-78), 6-2 | Robert F. Kennedy Stadium (4-3) | 96-51 | Won 7 |
| » Starters: Dave McNally vs Casey Cox | First | -- |
| » Major-league debuts: Denny Riddleberger (Senators) |
| Wednesday, September 16 |
| » Lost to Senators (69-78), 2-0 | Robert F. Kennedy Stadium (4-4) | 96-52 | |
| » Starters: Jim Palmer vs Bill Gogolewski | First | -- |
| Thursday, September 17 |
| » Lost to Senators (70-78), 2-0 | Robert F. Kennedy Stadium (4-5) | 96-53 | Lost 2 |
| » Starters: Mike Cuellar vs Dick Bosman | First | -- |
| » Major-league debuts: Johnny Oates (Orioles) |
| Friday, September 18 |
| » Defeated Indians (73-78), 4-3 | Memorial Stadium (51-21) | 97-53 | |
| » Starters: Steve Hargan vs Tom Phoebus | First | -- |
| » Major-league debuts: Don Baylor and Roger Freed (Orioles) |
| Saturday, September 19 |
| » Lost to Indians (74-78), 4-2 | Memorial Stadium (51-22) | 97-54 | |
| » Starters: Jim Rittwage vs Dave McNally | First | -- |
| Sunday, September 20 |
| » Defeated Indians (74-79), 7-0 | Memorial Stadium (52-22) | 98-54 | |
| » Starters: Mike Paul vs Jim Palmer | First | -- |
| Monday, September 21 |
| » Defeated Tigers (76-77), 4-3 | Memorial Stadium (53-22) | 99-54 | Won 2 |
| » Starters: Joe Niekro vs Marcelino Lopez | First | -- |
| Tuesday, September 22 |
| » Defeated Tigers (76-78), 10-2 | Memorial Stadium (54-22) | 100-54 | Won 3 |
| » Starters: Bob Reed vs Tom Phoebus | First | -- |
| Thursday, September 24 |
| » Defeated Tigers (76-79), 7-4 | Memorial Stadium (55-22) | 101-54 | Won 4 |
| » Starters: John Hiller vs Mike Cuellar | First | -- |
| Friday, September 25 |
| » Defeated Indians (75-82), 9-7 | Cleveland Stadium (5-2) | 102-54 | Won 5 |
| » Starters: Dave McNally vs Jim Rittwage | First | -- |
| Saturday, September 26 |
| » Defeated Indians (75-83), 7-4 | Cleveland Stadium (6-2) | 103-54 | Won 6 |
| » Starters: Jim Palmer vs Mike Paul | First | -- |
| Sunday, September 27 |
| » Defeated Indians (75-84), 4-3 | Cleveland Stadium (7-2) | 104-54 | Won 7 |
| » Starters: Jim Hardin vs Sam McDowell | First | -- |
| Tuesday, September 29 |
| » Defeated Senators (70-89), 3-2 | Memorial Stadium (56-22) | 105-54 | Won 8 |
| » Starters: Joe Coleman vs Mike Cuellar | First | -- |
| » Defeated Senators (70-90), 3-2 | Memorial Stadium (57-22) | 106-54 | Won 9 |
| » Starters: Jackie Brown vs Tom Phoebus | First | -- |
| Wednesday, September 30 |
| » Defeated Senators (70-91), 6-2 | Memorial Stadium (58-22) | 107-54 | Won 10 |
| » Starters: Bill Gogolewski vs Dave McNally | First | -- |
| Thursday, October 1 |
| » Defeated Senators (70-92), 3-2 | Memorial Stadium (59-22) | 108-54 | Won 11 |
| » Starters: Dick Bosman vs Jim Palmer | First | -- |
| Wednesday, December 9 |
| Future Oriole Tony Tarasco is born in New York, NY. |
Game information provided by Retrosheet (www.retrosheet.org) |