| Tuesday, January 27 |
| Future Cub Jessie Hollins is born in Conroe, TX. |
| Wednesday, March 4 |
| Future Cub Dave Stevens is born in Fullerton, CA. |
| Thursday, April 2 |
| Future Cub Jon Lieber is born in Council Bluffs, IA. |
| Monday, April 6 |
| » Major-league debuts: Dick Such (Senators) |
| Tuesday, April 7 |
| » Lost to Phillies (1-0), 2-0 | Shibe Park (0-1) | 0-1 | |
| » Starters: Fergie Jenkins vs Chris Short | Third | 1 out |
| » Major-league debuts: Larry Bowa and Denny Doyle (Phillies) |
| Thursday, April 9 |
| » Lost to Phillies (2-0), 5-3 | Shibe Park (0-2) | 0-2 | Lost 2 |
| » Starters: Ken Holtzman vs Rick Wise | Third | 2 out |
| Friday, April 10 |
| » Defeated Expos (0-4), 2-1 | Parc Jarry (1-0) | 1-2 | |
| » Starters: Bill Hands vs Joe Sparma | Second | 2 out |
| Sunday, April 12 |
| » Lost to Expos (1-4), 2-0 | Parc Jarry (1-1) | 1-3 | |
| » Starters: Fergie Jenkins vs Bill Stoneman | Second | 1½ out |
| Former Cub Red Shannon dies in Jersey City, NJ at the age of 74. |
| Tuesday, April 14 |
| » Defeated Phillies (3-3), 5-4 | Wrigley Field (1-0) | 2-3 | |
| » Starters: Chris Short vs Ken Holtzman | Third | 1½ out |
| Wednesday, April 15 |
| » Defeated Phillies (3-4), 5-1 | Wrigley Field (2-0) | 3-3 | Won 2 |
| » Starters: Rick Wise vs Bill Hands | Third | 1½ out |
| Former Cub Ripper Collins dies in New Haven, NY at the age of 67. |
| Thursday, April 16 |
| » Defeated Phillies (3-5), 6-5 | Wrigley Field (3-0) | 4-3 | Won 3 |
| » Starters: Woodie Fryman vs Joe Decker | Second | 1 out |
| Former Cub Mal Eason dies in Douglas, AZ at the age of 92. |
| Friday, April 17 |
| » Defeated Expos (1-7), 8-7 | Wrigley Field (4-0) | 5-3 | Won 4 |
| » Starters: Bill Stoneman vs Fergie Jenkins | Second | 1 out |
| Saturday, April 18 |
| » Defeated Expos (1-8), 8-1 | Wrigley Field (5-0) | 6-3 | Won 5 |
| » Starters: Steve Renko vs Ken Holtzman | Second | 1 out |
| Tuesday, April 21 |
| » Defeated Cardinals (7-3), 7-4 | Wrigley Field (6-0) | 7-3 | Won 6 |
| » Starters: Bob Gibson vs Bill Hands | First | -- |
| Wednesday, April 22 |
| » Defeated Cardinals (7-4), 7-5 | Wrigley Field (7-0) | 8-3 | Won 7 |
| » Starters: Mike Torrez vs Fergie Jenkins | First | -- |
| Friday, April 24 |
| » Defeated Astros (7-10), 6-3 | Wrigley Field (8-0) | 9-3 | Won 8 |
| » Starters: Tom Griffin vs Ken Holtzman | First | -- |
| Saturday, April 25 |
| » Defeated Astros (7-11), 11-5 | Wrigley Field (9-0) | 10-3 | Won 9 |
| » Starters: Jim Bouton vs Bill Hands | First | -- |
| Sunday, April 26 |
| » Defeated Astros (7-12), 6-3 | Wrigley Field (10-0) | 11-3 | Won 10 |
| » Starters: Larry Dierker vs Fergie Jenkins | First | -- |
| Monday, April 27 |
| » Defeated Pirates (10-7), 1-0 | Forbes Field (1-0) | 12-3 | Won 11 |
| » Starters: Joe Decker vs Steve Blass | First | -- |
| Tuesday, April 28 |
| » Lost to Pirates (11-7), 6-1 | Forbes Field (1-1) | 12-4 | |
| » Starters: Ken Holtzman vs Luke Walker | First | -- |
| Wednesday, April 29 |
| » Defeated Pirates (11-8), 10-5 | Forbes Field (2-1) | 13-4 | |
| » Starters: Bill Hands vs Bob Moose | First | -- |
| Thursday, April 30 |
| » Lost to Braves (10-11), 9-2 | Atlanta-Fulton County Stadium (0-1) | 13-5 | |
| » Starters: Fergie Jenkins vs George Stone | First | -- |
| » Major-league debuts: Larry Gura (Cubs) |
| Friday, May 1 |
| » Lost to Braves (11-11), 3-2 | Atlanta-Fulton County Stadium (0-2) | 13-6 | Lost 2 |
| » Starters: Joe Decker vs Phil Niekro | First | -- |
| Saturday, May 2 |
| » Lost to Braves (12-11), 4-2 | Atlanta-Fulton County Stadium (0-3) | 13-7 | Lost 3 |
| » Starters: Ken Holtzman vs Pat Jarvis | First | -- |
| Monday, May 4 |
| » Lost to Astros (11-15), 7-2 | Astrodome (0-1) | 13-8 | Lost 4 |
| » Starters: Bill Hands vs Jim Bouton | First | -- |
| Tuesday, May 5 |
| » Lost to Astros (12-15), 3-1 | Astrodome (0-2) | 13-9 | Lost 5 |
| » Starters: Fergie Jenkins vs Larry Dierker | First | -- |
| Wednesday, May 6 |
| » Major-league debuts: Del Bates (Phillies) |
| Thursday, May 7 |
| » Lost to Reds (22-6), 5-2 | Wrigley Field (10-1) | 13-10 | Lost 6 |
| » Starters: Jim McGlothlin vs Joe Decker | First | -- |
| Friday, May 8 |
| » Defeated Reds (22-7), 10-7 | Wrigley Field (11-1) | 14-10 | |
| » Starters: Jim Merritt vs Ken Holtzman | First | -- |
| Saturday, May 9 |
| » Defeated Reds (22-8), 8-1 | Wrigley Field (12-1) | 15-10 | Won 2 |
| » Starters: Gary Nolan vs Bill Hands | First | -- |
| Sunday, May 10 |
| » Lost to Reds (23-8), 7-6 | Wrigley Field (12-2) | 15-11 | |
| » Starters: Wayne Simpson vs Fergie Jenkins | First | -- |
| Monday, May 11 |
| » Lost to Braves (18-12), 7-6 | Wrigley Field (12-3) | 15-12 | Lost 2 |
| » Starters: Phil Niekro vs Joe Decker | First | -- |
| Tuesday, May 12 |
| » Defeated Braves (18-13), 4-3 | Wrigley Field (13-3) | 16-12 | |
| » Starters: Pat Jarvis vs Ken Holtzman | First | -- |
| Wednesday, May 13 |
| » Lost to Mets (16-16), 4-0 | Wrigley Field (13-4) | 16-13 | |
| » Starters: Gary Gentry vs Bill Hands | First | -- |
| Friday, May 15 |
| » Lost to Cardinals (15-15), 1-0 | Busch Stadium II (0-1) | 16-14 | Lost 2 |
| » Starters: Joe Decker vs Mike Torrez | First | -- |
| Saturday, May 16 |
| » Defeated Cardinals (15-16), 3-2 | Busch Stadium II (1-1) | 17-14 | |
| » Starters: Ken Holtzman vs Steve Carlton | First | -- |
| Former Cub Dutch Ruether dies in Phoenix, AZ at the age of 77. |
| Sunday, May 17 |
| » Lost to Cardinals (16-16), 4-3 | Busch Stadium II (1-2) | 17-15 | |
| » Starters: Fergie Jenkins vs Nelson Briles | First | -- |
| Monday, May 18 |
| » Defeated Reds (27-11), 12-5 | Crosley Field (1-0) | 18-15 | |
| » Starters: Bill Hands vs Ray Washburn | First | -- |
| Tuesday, May 19 |
| » Lost to Reds (28-11), 3-1 | Crosley Field (1-1) | 18-16 | |
| » Starters: Joe Decker vs Gary Nolan | First | -- |
| Friday, May 22 |
| » Defeated Mets (19-19), 6-4 | Shea Stadium (1-0) | 19-16 | |
| » Starters: Ken Holtzman vs Jerry Koosman | First | -- |
| Saturday, May 23 |
| » Defeated Mets (19-20), 14-8 | Shea Stadium (2-0) | 20-16 | Won 2 |
| » Starters: Fergie Jenkins vs Gary Gentry | First | -- |
| Future Cub Ricky Gutierrez is born in Miami, FL. |
| Sunday, May 24 |
| » Defeated Mets (19-21), 3-1 | Shea Stadium (3-0) | 21-16 | Won 3 |
| » Starters: Bill Hands vs Tom Seaver | First | -- |
| » Lost to Mets (20-21), 3-1 | Shea Stadium (3-1) | 21-17 | |
| » Starters: Joe Decker vs Nolan Ryan | First | -- |
| Tuesday, May 26 |
| » Defeated Pirates (20-24), 6-3 | Wrigley Field (14-4) | 22-17 | |
| » Starters: Steve Blass vs Ken Holtzman | First | -- |
| Wednesday, May 27 |
| » Lost to Pirates (21-24), 4-0 | Wrigley Field (14-5) | 22-18 | |
| » Starters: Bob Moose vs Fergie Jenkins | First | -- |
| Thursday, May 28 |
| » Defeated Pirates (21-25), 8-7 | Wrigley Field (15-5) | 23-18 | |
| » Starters: Dock Ellis vs Bill Hands | First | -- |
| Saturday, May 30 |
| » Lost to Padres (22-29), 11-4 | Wrigley Field (15-6) | 23-19 | |
| » Starters: Clay Kirby vs Ken Holtzman | First | -- |
| » Defeated Padres (22-30), 8-7 | Wrigley Field (16-6) | 24-19 | |
| » Starters: Pat Dobson vs Joe Decker | First | -- |
| Sunday, May 31 |
| » Defeated Padres (22-31), 7-4 | Wrigley Field (17-6) | 25-19 | Won 2 |
| » Starters: Mike Corkins vs Fergie Jenkins | First | -- |
| Monday, June 1 |
| » Lost to Dodgers (29-20), 5-4 | Wrigley Field (17-7) | 25-20 | |
| » Starters: Don Sutton vs Bill Hands | First | -- |
| Wednesday, June 3 |
| » Defeated Dodgers (29-21), 6-5 | Wrigley Field (18-7) | 26-20 | |
| » Starters: Alan Foster vs Ken Holtzman | First | -- |
| Former Cub Jakie May dies in Wendell, NC at the age of 75. |
| Friday, June 5 |
| » Defeated Giants (24-29), 12-8 | Wrigley Field (19-7) | 27-20 | Won 2 |
| » Starters: Juan Marichal vs Fergie Jenkins | First | -- |
| Saturday, June 6 |
| » Lost to Giants (25-29), 5-3 | Wrigley Field (19-8) | 27-21 | |
| » Starters: Gaylord Perry vs Bill Hands | First | -- |
| Sunday, June 7 |
| » Defeated Giants (25-30), 8-4 | Wrigley Field (20-8) | 28-21 | |
| » Starters: Rich Robertson vs Ken Holtzman | First | -- |
| Tuesday, June 9 |
| » Defeated Padres (25-34), 7-3 | San Diego/Jack Murphy Stadium (1-0) | 29-21 | Won 2 |
| » Starters: Fergie Jenkins vs Clay Kirby | First | -- |
| Wednesday, June 10 |
| » Lost to Padres (26-34), 11-8 | San Diego/Jack Murphy Stadium (1-1) | 29-22 | |
| » Starters: Jim Colborn vs Pat Dobson | First | -- |
| Thursday, June 11 |
| » Defeated Padres (26-35), 7-1 | San Diego/Jack Murphy Stadium (2-1) | 30-22 | |
| » Starters: Bill Hands vs Mike Corkins | First | -- |
| Friday, June 12 |
| » Defeated Dodgers (32-26), 2-1 | Dodger Stadium (1-0) | 31-22 | Won 2 |
| » Starters: Ken Holtzman vs Alan Foster | First | -- |
| Future Cub Damon Buford is born in Baltimore, MD. |
| Saturday, June 13 |
| » Defeated Dodgers (32-27), 7-1 | Dodger Stadium (2-0) | 32-22 | Won 3 |
| » Starters: Fergie Jenkins vs Claude Osteen | First | -- |
| Sunday, June 14 |
| » Lost to Dodgers (33-27), 5-4 | Dodger Stadium (2-1) | 32-23 | |
| » Starters: Joe Decker vs Bill Singer | First | -- |
| Tuesday, June 16 |
| » Lost to Giants (29-32), 3-2 | Candlestick Park (0-1) | 32-24 | Lost 2 |
| » Starters: Bill Hands vs Gaylord Perry | First | -- |
| » Major-league debuts: Roger Metzger (Cubs) |
| Wednesday, June 17 |
| » Defeated Giants (29-33), 6-1 | Candlestick Park (1-1) | 33-24 | |
| » Starters: Ken Holtzman vs Skip Pitlock | First | -- |
| Thursday, June 18 |
| » Defeated Giants (29-34), 6-0 | Candlestick Park (2-1) | 34-24 | Won 2 |
| » Starters: Fergie Jenkins vs Rich Robertson | First | -- |
| Friday, June 19 |
| » Lost to Cardinals (29-31), 5-3 | Wrigley Field (20-9) | 34-25 | |
| » Starters: Chuck Taylor vs Joe Decker | First | -- |
| Saturday, June 20 |
| » Defeated Cardinals (29-32), 8-3 | Wrigley Field (21-9) | 35-25 | |
| » Starters: Mike Torrez vs Bill Hands | First | -- |
| Sunday, June 21 |
| » Lost to Cardinals (30-32), 3-0 | Wrigley Field (21-10) | 35-26 | |
| » Starters: Steve Carlton vs Ken Holtzman | First | -- |
| » Lost to Cardinals (31-32), 3-2 | Wrigley Field (21-11) | 35-27 | Lost 2 |
| » Starters: Bob Gibson vs Jim Colborn | First | -- |
| Monday, June 22 |
| » Lost to Mets (33-31), 9-5 | Wrigley Field (21-12) | 35-28 | Lost 3 |
| » Starters: Gary Gentry vs Fergie Jenkins | First | -- |
| Tuesday, June 23 |
| » Lost to Mets (34-31), 12-10 | Wrigley Field (21-13) | 35-29 | Lost 4 |
| » Starters: Ray Sadecki vs Joe Decker | First | -- |
| Wednesday, June 24 |
| » Lost to Mets (35-31), 9-5 | Wrigley Field (21-14) | 35-30 | Lost 5 |
| » Starters: Tom Seaver vs Bill Hands | Second | ½ out |
| » Lost to Mets (36-31), 6-1 | Wrigley Field (21-15) | 35-31 | Lost 6 |
| » Starters: Nolan Ryan vs Archie Reynolds | Second | ½ out |
| » Major-league debuts: Ken Singleton (Mets) |
| Thursday, June 25 |
| » Lost to Mets (37-31), 8-3 | Wrigley Field (21-16) | 35-32 | Lost 7 |
| » Starters: Jerry Koosman vs Ken Holtzman | Second | 1½ out |
| Saturday, June 27 |
| » Lost to Pirates (38-35), 2-1 | Forbes Field (2-2) | 35-33 | Lost 8 |
| » Starters: Fergie Jenkins vs Dock Ellis | Third | 2 out |
| Sunday, June 28 |
| » Lost to Pirates (39-35), 3-2 | Forbes Field (2-3) | 35-34 | Lost 9 |
| » Starters: Bill Hands vs Bob Moose | Third | 2½ out |
| » Lost to Pirates (40-35), 4-1 | Forbes Field (2-4) | 35-35 | Lost 10 |
| » Starters: Milt Pappas vs Jim Nelson | Third | 2½ out |
| » Major-league debuts: Gene Clines (Pirates) |
| Monday, June 29 |
| » Lost to Cardinals (36-37), 8-6 | Busch Stadium II (1-3) | 35-36 | Lost 11 |
| » Starters: Ken Holtzman vs Steve Carlton | Third | 3½ out |
| Tuesday, June 30 |
| » Lost to Cardinals (37-37), 5-4 | Busch Stadium II (1-4) | 35-37 | Lost 12 |
| » Starters: Joe Decker vs Bob Gibson | Fourth | 4½ out |
| Wednesday, July 1 |
| » Defeated Cardinals (37-38), 5-0 | Busch Stadium II (2-4) | 36-37 | |
| » Starters: Fergie Jenkins vs Jerry Reuss | Third | 3½ out |
| Friday, July 3 |
| » Lost to Pirates (42-37), 16-14 | Wrigley Field (21-17) | 36-38 | |
| » Starters: Jim Nelson vs Bill Hands | Fourth | 3½ out |
| Saturday, July 4 |
| » Lost to Pirates (43-37), 10-6 | Wrigley Field (21-18) | 36-39 | Lost 2 |
| » Starters: Steve Blass vs Ken Holtzman | Third | 4 out |
| » Defeated Pirates (43-38), 7-2 | Wrigley Field (22-18) | 37-39 | |
| » Starters: Bob Veale vs Milt Pappas | Third | 4 out |
| Sunday, July 5 |
| » Lost to Pirates (44-38), 5-2 | Wrigley Field (22-19) | 37-40 | |
| » Starters: Dock Ellis vs Fergie Jenkins | Fourth | 5 out |
| Monday, July 6 |
| » Defeated Expos (33-47), 3-2 | Wrigley Field (23-19) | 38-40 | |
| » Starters: Carl Morton vs Bill Hands | Third | 4½ out |
| » Defeated Expos (33-48), 14-2 | Wrigley Field (24-19) | 39-40 | Won 2 |
| » Starters: Mike Wegener vs Joe Decker | Third | 4½ out |
| Tuesday, July 7 |
| » Defeated Expos (33-49), 10-7 | Wrigley Field (25-19) | 40-40 | Won 3 |
| » Starters: Howie Reed vs Larry Gura | Third | 4½ out |
| Former Cub Harry Wolter dies in Palo Alto, CA at the age of 86. |
| Wednesday, July 8 |
| » Defeated Expos (33-50), 5-1 | Wrigley Field (26-19) | 41-40 | Won 4 |
| » Starters: Steve Renko vs Milt Pappas | Third | 5 out |
| » Lost to Expos (34-50), 5-4 | Wrigley Field (26-20) | 41-41 | |
| » Starters: Bill Stoneman vs Ken Holtzman | Third | 5 out |
| Friday, July 10 |
| » Defeated Phillies (35-48), 2-0 | Wrigley Field (27-20) | 42-41 | |
| » Starters: Grant Jackson vs Fergie Jenkins | Third | 4½ out |
| Saturday, July 11 |
| » Lost to Phillies (36-48), 10-4 | Wrigley Field (27-21) | 42-42 | |
| » Starters: Jim Bunning vs Bill Hands | Third | 5 out |
| Sunday, July 12 |
| » Defeated Phillies (36-49), 10-2 | Wrigley Field (28-21) | 43-42 | |
| » Starters: Chris Short vs Ken Holtzman | Third | 5 out |
| Thursday, July 16 |
| » Lost to Astros (38-51), 2-1 | Astrodome (0-3) | 43-43 | |
| » Starters: Ken Holtzman vs Don Wilson | Third | 5 out |
| Friday, July 17 |
| » Lost to Astros (39-51), 5-2 | Astrodome (0-4) | 43-44 | Lost 2 |
| » Starters: Fergie Jenkins vs Larry Dierker | Third | 6 out |
| Saturday, July 18 |
| » Defeated Astros (39-52), 7-3 | Astrodome (1-4) | 44-44 | |
| » Starters: Bill Hands vs Jack Billingham | Third | 5 out |
| Sunday, July 19 |
| » Defeated Astros (39-53), 7-1 | Astrodome (2-4) | 45-44 | Won 2 |
| » Starters: Milt Pappas vs Tom Griffin | Third | 5 out |
| Monday, July 20 |
| » Lost to Braves (45-46), 3-1 | Atlanta-Fulton County Stadium (0-4) | 45-45 | |
| » Starters: Ken Holtzman vs Phil Niekro | Third | 5½ out |
| » Lost to Braves (46-46), 5-0 | Atlanta-Fulton County Stadium (0-5) | 45-46 | Lost 2 |
| » Starters: Joe Decker vs Don Cardwell | Third | 5½ out |
| Tuesday, July 21 |
| » Defeated Braves (46-47), 8-2 | Atlanta-Fulton County Stadium (1-5) | 46-46 | |
| » Starters: Fergie Jenkins vs Pat Jarvis | Third | 4½ out |
| Wednesday, July 22 |
| » Defeated Reds (67-29), 10-2 | Wrigley Field (29-21) | 47-46 | Won 2 |
| » Starters: Jim Merritt vs Bill Hands | Third | 4½ out |
| Thursday, July 23 |
| » Defeated Reds (67-30), 1-0 | Wrigley Field (30-21) | 48-46 | Won 3 |
| » Starters: Jim McGlothlin vs Milt Pappas | Third | 4½ out |
| Friday, July 24 |
| » Defeated Braves (46-50), 11-1 | Wrigley Field (31-21) | 49-46 | Won 4 |
| » Starters: Ron Reed vs Ken Holtzman | Third | 4½ out |
| Saturday, July 25 |
| » Lost to Braves (47-50), 9-0 | Wrigley Field (31-22) | 49-47 | |
| » Starters: Phil Niekro vs Fergie Jenkins | Third | 4½ out |
| Former Cub Herb Hunter dies in Orlando, FL at the age of 74. |
| Sunday, July 26 |
| » Lost to Braves (48-50), 8-3 | Wrigley Field (31-23) | 49-48 | Lost 2 |
| » Starters: Pat Jarvis vs Bill Hands | Third | 4 out |
| » Defeated Braves (48-51), 7-6 | Wrigley Field (32-23) | 50-48 | |
| » Starters: Don Cardwell vs Jim Colborn | Third | 4 out |
| Monday, July 27 |
| Former Cub Whitey Platt dies in W.Palm Beach, FL at the age of 50. |
| Tuesday, July 28 |
| » Lost to Astros (46-54), 10-4 | Wrigley Field (32-24) | 50-49 | |
| » Starters: Jack Billingham vs Milt Pappas | Third | 5 out |
| Wednesday, July 29 |
| » Defeated Astros (46-55), 9-2 | Wrigley Field (33-24) | 51-49 | |
| » Starters: Larry Dierker vs Ken Holtzman | Third | 4 out |
| Thursday, July 30 |
| » Defeated Astros (46-56), 6-3 | Wrigley Field (34-24) | 52-49 | Won 2 |
| » Starters: Tom Griffin vs Fergie Jenkins | Third | 3 out |
| Friday, July 31 |
| » Defeated Reds (72-33), 7-1 | Riverfront Stadium (1-0) | 53-49 | Won 3 |
| » Starters: Bill Hands vs Wayne Simpson | Third | 2 out |
| » Defeated Reds (72-34), 11-7 | Riverfront Stadium (2-0) | 54-49 | Won 4 |
| » Starters: Jim Colborn vs Jim Merritt | Third | 2 out |
| Saturday, August 1 |
| » Lost to Reds (73-34), 6-4 | Riverfront Stadium (2-1) | 54-50 | |
| » Starters: Milt Pappas vs Jim McGlothlin | Third | 3 out |
| Sunday, August 2 |
| » Lost to Reds (74-34), 4-3 | Riverfront Stadium (2-2) | 54-51 | Lost 2 |
| » Starters: Ken Holtzman vs Gary Nolan | Third | 3½ out |
| Former Cub Mike Cvengros dies in Hot Springs, AR at the age of 69. |
| Monday, August 3 |
| » Defeated Mets (56-49), 6-1 | Shea Stadium (4-1) | 55-51 | |
| » Starters: Fergie Jenkins vs Jerry Koosman | Third | 2½ out |
| Tuesday, August 4 |
| » Lost to Mets (57-49), 4-0 | Shea Stadium (4-2) | 55-52 | |
| » Starters: Joe Decker vs Nolan Ryan | Third | 3½ out |
| Wednesday, August 5 |
| » Lost to Expos (48-61), 6-2 | Parc Jarry (1-2) | 55-53 | Lost 2 |
| » Starters: Milt Pappas vs Mike Wegener | Third | 4 out |
| » Defeated Expos (48-62), 11-3 | Parc Jarry (2-2) | 56-53 | |
| » Starters: Larry Gura vs Steve Renko | Third | 4 out |
| Thursday, August 6 |
| » Defeated Expos (48-63), 4-2 | Parc Jarry (3-2) | 57-53 | Won 2 |
| » Starters: Ken Holtzman vs Carl Morton | Third | 4½ out |
| Friday, August 7 |
| » Lost to Phillies (50-59), 4-1 | Shibe Park (0-3) | 57-54 | |
| » Starters: Fergie Jenkins vs Grant Jackson | Third | 5½ out |
| Future Cub Marc Pisciotta is born in Edison, NJ. |
| Saturday, August 8 |
| » Lost to Phillies (51-59), 6-3 | Shibe Park (0-4) | 57-55 | Lost 2 |
| » Starters: Bill Hands vs Chris Short | Third | 5½ out |
| Sunday, August 9 |
| » Defeated Phillies (51-60), 4-1 | Shibe Park (1-4) | 58-55 | |
| » Starters: Milt Pappas vs Rick Wise | Third | 6 out |
| » Lost to Phillies (52-60), 6-1 | Shibe Park (1-5) | 58-56 | |
| » Starters: Larry Gura vs Barry Lersch | Third | 6 out |
| Tuesday, August 11 |
| » Defeated Giants (55-58), 4-1 | Wrigley Field (35-24) | 59-56 | |
| » Starters: Frank Reberger vs Fergie Jenkins | Third | 4½ out |
| Wednesday, August 12 |
| » Lost to Giants (56-58), 6-3 | Wrigley Field (35-25) | 59-57 | |
| » Starters: Ron Bryant vs Bill Hands | Third | 4½ out |
| Thursday, August 13 |
| » Defeated Giants (56-59), 6-3 | Wrigley Field (36-25) | 60-57 | |
| » Starters: Gaylord Perry vs Milt Pappas | Third | 4 out |
| Friday, August 14 |
| » Lost to Dodgers (66-49), 13-9 | Wrigley Field (36-26) | 60-58 | |
| » Starters: Don Sutton vs Jim Colborn | Third | 5½ out |
| Saturday, August 15 |
| » Lost to Dodgers (67-49), 9-7 | Wrigley Field (36-27) | 60-59 | Lost 2 |
| » Starters: Alan Foster vs Fergie Jenkins | Third | 6 out |
| » Defeated Dodgers (67-50), 13-2 | Wrigley Field (37-27) | 61-59 | |
| » Starters: Joe Moeller vs Ken Holtzman | Third | 6 out |
| Sunday, August 16 |
| » Defeated Dodgers (67-51), 5-2 | Wrigley Field (38-27) | 62-59 | Won 2 |
| » Starters: Claude Osteen vs Bill Hands | Third | 5 out |
| Monday, August 17 |
| » Defeated Padres (47-75), 7-0 | Wrigley Field (39-27) | 63-59 | Won 3 |
| » Starters: Clay Kirby vs Milt Pappas | Third | 4 out |
| Tuesday, August 18 |
| » Lost to Padres (48-75), 11-3 | Wrigley Field (39-28) | 63-60 | |
| » Starters: Pat Dobson vs Joe Decker | Third | 5 out |
| Wednesday, August 19 |
| » Defeated Padres (48-76), 12-2 | Wrigley Field (40-28) | 64-60 | |
| » Starters: Dave Roberts vs Fergie Jenkins | Third | 4 out |
| Friday, August 21 |
| » Lost to Giants (62-61), 5-1 | Candlestick Park (2-2) | 64-61 | |
| » Starters: Bill Hands vs Frank Reberger | Third | 4 out |
| Saturday, August 22 |
| » Defeated Giants (62-62), 15-0 | Candlestick Park (3-2) | 65-61 | |
| » Starters: Ken Holtzman vs Gaylord Perry | Third | 4 out |
| Sunday, August 23 |
| » Lost to Giants (63-62), 4-3 | Candlestick Park (3-3) | 65-62 | |
| » Starters: Milt Pappas vs Juan Marichal | Third | 5 out |
| Monday, August 24 |
| » Defeated Dodgers (70-55), 4-2 | Dodger Stadium (3-1) | 66-62 | |
| » Starters: Fergie Jenkins vs Sandy Vance | Third | 4½ out |
| Tuesday, August 25 |
| » Lost to Dodgers (71-55), 4-1 | Dodger Stadium (3-2) | 66-63 | |
| » Starters: Bill Hands vs Joe Moeller | Third | 4½ out |
| Future Cub Doug Glanville is born in Hackensack, NJ. |
| Wednesday, August 26 |
| » Lost to Dodgers (72-55), 8-5 | Dodger Stadium (3-3) | 66-64 | Lost 2 |
| » Starters: Ken Holtzman vs Claude Osteen | Third | 4½ out |
| Thursday, August 27 |
| » Defeated Padres (50-80), 5-1 | San Diego/Jack Murphy Stadium (3-1) | 67-64 | |
| » Starters: Milt Pappas vs Earl Wilson | Third | 4 out |
| Friday, August 28 |
| » Defeated Padres (50-81), 8-4 | San Diego/Jack Murphy Stadium (4-1) | 68-64 | Won 2 |
| » Starters: Fergie Jenkins vs Clay Kirby | Third | 3 out |
| Sunday, August 30 |
| » Defeated Padres (50-82), 3-0 | San Diego/Jack Murphy Stadium (5-1) | 69-64 | Won 3 |
| » Starters: Bill Hands vs Dave Roberts | Second | 1 out |
| Tuesday, September 1 |
| » Lost to Phillies (63-70), 3-2 | Wrigley Field (40-29) | 69-65 | |
| » Starters: Jim Bunning vs Ken Holtzman | Third | 2 out |
| Wednesday, September 2 |
| » Defeated Phillies (63-71), 17-2 | Wrigley Field (41-29) | 70-65 | |
| » Starters: Grant Jackson vs Milt Pappas | Third | 1 out |
| » Major-league debuts: Terry Hughes (Cubs) |
| Thursday, September 3 |
| » Defeated Phillies (63-72), 7-2 | Wrigley Field (42-29) | 71-65 | Won 2 |
| » Starters: Chris Short vs Fergie Jenkins | Second | ½ out |
| Friday, September 4 |
| » Defeated Mets (70-66), 7-4 | Wrigley Field (43-29) | 72-65 | Won 3 |
| » Starters: Nolan Ryan vs Bill Hands | Second | ½ out |
| Saturday, September 5 |
| » Lost to Mets (71-66), 5-3 | Wrigley Field (43-30) | 72-66 | |
| » Starters: Jerry Koosman vs Ken Holtzman | Second | 1½ out |
| Monday, September 7 |
| » Lost to Pirates (75-64), 8-3 | Three Rivers Stadium (0-1) | 72-67 | Lost 2 |
| » Starters: Milt Pappas vs Bob Moose | Third | 2 out |
| » Defeated Pirates (75-65), 9-2 | Three Rivers Stadium (1-1) | 73-67 | |
| » Starters: Fergie Jenkins vs Bob Veale | Third | 2 out |
| » Major-league debuts: Ed Acosta (Pirates) |
| Tuesday, September 8 |
| » Defeated Pirates (75-66), 10-3 | Three Rivers Stadium (2-1) | 74-67 | Won 2 |
| » Starters: Bill Hands vs Steve Blass | Third | 1 out |
| » Major-league debuts: Milt May (Pirates) |
| Wednesday, September 9 |
| » Lost to Expos (61-80), 3-2 | Wrigley Field (43-31) | 74-68 | |
| » Starters: Bill Stoneman vs Ken Holtzman | Second | 1 out |
| Thursday, September 10 |
| » Defeated Expos (61-81), 9-3 | Wrigley Field (44-31) | 75-68 | |
| » Starters: John O'Donoghue vs Milt Pappas | Second | 1 out |
| Friday, September 11 |
| » Major-league debuts: John Vukovich (Phillies) |
| Saturday, September 12 |
| » Lost to Pirates (77-67), 5-4 | Wrigley Field (44-32) | 75-69 | |
| » Starters: Bob Moose vs Fergie Jenkins | Third | 2 out |
| Sunday, September 13 |
| » Defeated Pirates (77-68), 3-2 | Wrigley Field (45-32) | 76-69 | |
| » Starters: Steve Blass vs Bill Hands | Third | 1 out |
| Tuesday, September 15 |
| » Defeated Cardinals (70-78), 5-3 | Wrigley Field (46-32) | 77-69 | Won 2 |
| » Starters: Steve Carlton vs Ken Holtzman | Third | 1 out |
| Wednesday, September 16 |
| » Lost to Cardinals (71-78), 8-1 | Wrigley Field (46-33) | 77-70 | |
| » Starters: Bob Gibson vs Milt Pappas | Second | 2 out |
| Thursday, September 17 |
| » Lost to Cardinals (72-78), 9-2 | Wrigley Field (46-34) | 77-71 | Lost 2 |
| » Starters: Jerry Reuss vs Bill Hands | Third | 2 out |
| Friday, September 18 |
| » Defeated Expos (66-83), 3-2 | Parc Jarry (4-2) | 78-71 | |
| » Starters: Fergie Jenkins vs Bill Stoneman | Second | 1½ out |
| » Defeated Expos (66-84), 5-4 | Parc Jarry (5-2) | 79-71 | Won 2 |
| » Starters: Bob Miller vs Mike Wegener | Second | 1½ out |
| Future Cub Ozzie Timmons is born in Tampa, FL. |
| Saturday, September 19 |
| » Defeated Expos (66-85), 8-4 | Parc Jarry (6-2) | 80-71 | Won 3 |
| » Starters: Ken Holtzman vs Carl Morton | Second | 1½ out |
| Sunday, September 20 |
| » Lost to Expos (67-85), 6-4 | Parc Jarry (6-3) | 80-72 | |
| » Starters: Milt Pappas vs Steve Renko | Second | 2 out |
| Wednesday, September 23 |
| » Lost to Cardinals (73-81), 2-1 | Busch Stadium II (2-5) | 80-73 | Lost 2 |
| » Starters: Fergie Jenkins vs Bob Gibson | Third | 2½ out |
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