| Friday, January 2 |
| Future Cardinal Royce Clayton is born in Burbank, CA. |
| Friday, January 9 |
| Future Cardinal T.J. Mathews is born in Belleville, IL. |
| Wednesday, February 4 |
| Future Cardinal John Frascatore is born in Ozone Park, NY. |
| Tuesday, February 10 |
| Future Cardinal Alberto Castillo is born in San Juan De La Maguana, D.R. |
| Monday, April 6 |
| » Major-league debuts: Dick Such (Senators) |
| Wednesday, April 8 |
| » Defeated Expos (0-2), 7-2 | Parc Jarry (1-0) | 1-0 | |
| » Starters: Bob Gibson vs Bill Stoneman | First | -- |
| Thursday, April 9 |
| » Defeated Expos (0-3), 7-3 | Parc Jarry (2-0) | 2-0 | Won 2 |
| » Starters: Mike Torrez vs Steve Renko | First | -- |
| Friday, April 10 |
| » Defeated Mets (1-2), 7-3 | Busch Stadium II (1-0) | 3-0 | Won 3 |
| » Starters: Jim McAndrew vs George Culver | First | -- |
| Saturday, April 11 |
| » Lost to Mets (2-2), 4-1 | Busch Stadium II (1-1) | 3-1 | |
| » Starters: Gary Gentry vs Nelson Briles | First | -- |
| » Major-league debuts: Jim Campbell (Cardinals) |
| Sunday, April 12 |
| » Lost to Mets (3-2), 6-4 | Busch Stadium II (1-2) | 3-2 | Lost 2 |
| » Starters: Tom Seaver vs Steve Carlton | First | -- |
| Tuesday, April 14 |
| » Defeated Expos (1-5), 6-5 | Busch Stadium II (2-2) | 4-2 | |
| » Starters: Steve Renko vs Bob Gibson | First | -- |
| Wednesday, April 15 |
| » Defeated Expos (1-6), 10-0 | Busch Stadium II (3-2) | 5-2 | Won 2 |
| » Starters: Joe Sparma vs Mike Torrez | First | -- |
| Former Cardinal Ripper Collins dies in New Haven, NY at the age of 67. |
| Friday, April 17 |
| » Defeated Pirates (5-3), 5-2 | Forbes Field (1-0) | 6-2 | Won 3 |
| » Starters: George Culver vs Steve Blass | First | -- |
| Saturday, April 18 |
| » Defeated Pirates (5-4), 6-1 | Forbes Field (2-0) | 7-2 | Won 4 |
| » Starters: Steve Carlton vs Luke Walker | First | -- |
| Tuesday, April 21 |
| » Lost to Cubs (7-3), 7-4 | Wrigley Field (0-1) | 7-3 | |
| » Starters: Bob Gibson vs Bill Hands | First | -- |
| Wednesday, April 22 |
| » Lost to Cubs (8-3), 7-5 | Wrigley Field (0-2) | 7-4 | Lost 2 |
| » Starters: Mike Torrez vs Fergie Jenkins | Third | 1 out |
| Friday, April 24 |
| » Defeated Reds (13-5), 3-1 | Busch Stadium II (4-2) | 8-4 | |
| » Starters: Wayne Simpson vs George Culver | Second | 1 out |
| Saturday, April 25 |
| » Lost to Reds (14-5), 3-2 | Busch Stadium II (4-3) | 8-5 | |
| » Starters: Jim Merritt vs Steve Carlton | Third | 2 out |
| Sunday, April 26 |
| » Defeated Reds (14-6), 4-1 | Busch Stadium II (5-3) | 9-5 | |
| » Starters: Jim McGlothlin vs Bob Gibson | Second | 2 out |
| Tuesday, April 28 |
| » Lost to Braves (8-11), 3-2 | Busch Stadium II (5-4) | 9-6 | |
| » Starters: Pat Jarvis vs Mike Torrez | Third | 2½ out |
| Wednesday, April 29 |
| » Lost to Braves (9-11), 10-6 | Busch Stadium II (5-5) | 9-7 | Lost 2 |
| » Starters: Jim Nash vs George Culver | Third | 3½ out |
| Friday, May 1 |
| » Lost to Astros (8-14), 9-3 | Busch Stadium II (5-6) | 9-8 | Lost 3 |
| » Starters: Larry Dierker vs Steve Carlton | Third | 3 out |
| Saturday, May 2 |
| » Lost to Astros (9-14), 5-3 | Busch Stadium II (5-7) | 9-9 | Lost 4 |
| » Starters: Don Wilson vs Bob Gibson | Third | 3 out |
| Former Cardinal Art Delaney dies in Hayward, CA at the age of 76. |
| Sunday, May 3 |
| » Defeated Astros (9-15), 7-4 | Busch Stadium II (6-7) | 10-9 | |
| » Starters: Tom Griffin vs Nelson Briles | Third | 3 out |
| » Lost to Astros (10-15), 8-1 | Busch Stadium II (6-8) | 10-10 | |
| » Starters: Denny Lemaster vs George Culver | Third | 3 out |
| Monday, May 4 |
| » Lost to Reds (20-6), 7-3 | Crosley Field (0-1) | 10-11 | Lost 2 |
| » Starters: Mike Torrez vs Gary Nolan | Fourth | 3 out |
| Tuesday, May 5 |
| » Lost to Reds (21-6), 5-1 | Crosley Field (0-2) | 10-12 | Lost 3 |
| » Starters: Steve Carlton vs Wayne Simpson | Fourth | 3 out |
| Future Cardinal Juan Acevedo is born in Juarez, Mexico. |
| Friday, May 8 |
| » Lost to Braves (16-11), 8-7 | Atlanta-Fulton County Stadium (0-1) | 10-13 | Lost 4 |
| » Starters: Bob Gibson vs Pat Jarvis | Fourth | 3½ out |
| Saturday, May 9 |
| » Lost to Braves (17-11), 5-3 | Atlanta-Fulton County Stadium (0-2) | 10-14 | Lost 5 |
| » Starters: George Culver vs Jim Nash | Fourth | 4½ out |
| Sunday, May 10 |
| » Defeated Braves (17-12), 6-5 | Atlanta-Fulton County Stadium (1-2) | 11-14 | |
| » Starters: Mike Torrez vs George Stone | Fourth | 3½ out |
| Monday, May 11 |
| » Defeated Phillies (13-17), 3-0 | Busch Stadium II (7-8) | 12-14 | Won 2 |
| » Starters: Jim Bunning vs Steve Carlton | Third | 2½ out |
| Tuesday, May 12 |
| » Defeated Phillies (13-18), 9-5 | Busch Stadium II (8-8) | 13-14 | Won 3 |
| » Starters: Chris Short vs Nelson Briles | Third | 2½ out |
| Wednesday, May 13 |
| » Lost to Pirates (15-17), 5-1 | Busch Stadium II (8-9) | 13-15 | |
| » Starters: Bob Moose vs Bob Gibson | Fourth | 2½ out |
| Thursday, May 14 |
| » Defeated Pirates (15-18), 11-7 | Busch Stadium II (9-9) | 14-15 | |
| » Starters: Dock Ellis vs George Culver | Third | 2 out |
| Future Cardinal Larry Sutton is born in West Covina, CA. |
| Friday, May 15 |
| » Defeated Cubs (16-14), 1-0 | Busch Stadium II (10-9) | 15-15 | Won 2 |
| » Starters: Joe Decker vs Mike Torrez | Third | 1 out |
| Saturday, May 16 |
| » Lost to Cubs (17-14), 3-2 | Busch Stadium II (10-10) | 15-16 | |
| » Starters: Ken Holtzman vs Steve Carlton | Third | 2 out |
| Sunday, May 17 |
| » Defeated Cubs (17-15), 4-3 | Busch Stadium II (11-10) | 16-16 | |
| » Starters: Fergie Jenkins vs Nelson Briles | Third | 1 out |
| Monday, May 18 |
| » Lost to Astros (19-19), 6-0 | Astrodome (0-1) | 16-17 | |
| » Starters: Bob Gibson vs Larry Dierker | Third | 2 out |
| Tuesday, May 19 |
| » Defeated Astros (19-20), 12-3 | Astrodome (1-1) | 17-17 | |
| » Starters: Santiago Guzman vs Scipio Spinks | Third | 1 out |
| Wednesday, May 20 |
| » Defeated Astros (19-21), 3-2 | Astrodome (2-1) | 18-17 | Won 2 |
| » Starters: Mike Torrez vs Tom Griffin | Third | ½ out |
| Thursday, May 21 |
| » Lost to Phillies (15-23), 4-3 | Shibe Park (0-1) | 18-18 | |
| » Starters: Steve Carlton vs Woodie Fryman | Third | 1 out |
| Former Cardinal Les Fusselman dies in Cleveland, OH at the age of 50. |
| Friday, May 22 |
| » Defeated Phillies (15-24), 6-3 | Shibe Park (1-1) | 19-18 | |
| » Starters: Nelson Briles vs Grant Jackson | Second | 1 out |
| Saturday, May 23 |
| » Defeated Phillies (15-25), 3-1 | Shibe Park (2-1) | 20-18 | Won 2 |
| » Starters: Bob Gibson vs Jim Bunning | Second | 1 out |
| Sunday, May 24 |
| » Lost to Phillies (16-25), 6-5 | Shibe Park (2-2) | 20-19 | |
| » Starters: Santiago Guzman vs Chris Short | Second | 1½ out |
| Tuesday, May 26 |
| » Lost to Mets (21-21), 5-1 | Shea Stadium (0-1) | 20-20 | Lost 2 |
| » Starters: Mike Torrez vs Ray Sadecki | Second | 2½ out |
| Wednesday, May 27 |
| » Lost to Mets (22-21), 3-0 | Shea Stadium (0-2) | 20-21 | Lost 3 |
| » Starters: Steve Carlton vs Gary Gentry | Third | 2½ out |
| Thursday, May 28 |
| » Defeated Mets (22-22), 9-2 | Shea Stadium (1-2) | 21-21 | |
| » Starters: Bob Gibson vs Jim McAndrew | Second | 2½ out |
| Friday, May 29 |
| » Lost to Dodgers (26-20), 8-6 | Busch Stadium II (11-11) | 21-22 | |
| » Starters: Alan Foster vs Nelson Briles | Third | 3 out |
| Saturday, May 30 |
| » Lost to Dodgers (27-20), 7-6 | Busch Stadium II (11-12) | 21-23 | Lost 2 |
| » Starters: Claude Osteen vs Santiago Guzman | Third | 3½ out |
| Sunday, May 31 |
| » Lost to Dodgers (28-20), 8-6 | Busch Stadium II (11-13) | 21-24 | Lost 3 |
| » Starters: Sandy Vance vs Mike Torrez | Fourth | 4½ out |
| Monday, June 1 |
| Former Cardinal George Watkins dies in Houston, TX at the age of 70. |
| Tuesday, June 2 |
| » Defeated Giants (24-27), 12-1 | Busch Stadium II (12-13) | 22-24 | |
| » Starters: Gaylord Perry vs Steve Carlton | Third | 3½ out |
| Wednesday, June 3 |
| » Defeated Giants (24-28), 6-5 | Busch Stadium II (13-13) | 23-24 | Won 2 |
| » Starters: Rich Robertson vs Bob Gibson | Third | 3½ out |
| Former Cardinal Jakie May dies in Wendell, NC at the age of 75. |
| Friday, June 5 |
| » Lost to Padres (24-32), 3-2 | Busch Stadium II (13-14) | 23-25 | |
| » Starters: Pat Dobson vs Mike Torrez | Third | 4½ out |
| Saturday, June 6 |
| » Lost to Padres (25-32), 5-4 | Busch Stadium II (13-15) | 23-26 | Lost 2 |
| » Starters: Mike Corkins vs Steve Carlton | Fourth | 4½ out |
| Sunday, June 7 |
| » Defeated Padres (25-33), 10-7 | Busch Stadium II (14-15) | 24-26 | |
| » Starters: Danny Coombs vs Bob Gibson | Third | 4½ out |
| Tuesday, June 9 |
| » Defeated Dodgers (30-25), 4-0 | Dodger Stadium (1-0) | 25-26 | Won 2 |
| » Starters: Chuck Taylor vs Claude Osteen | Fourth | 4½ out |
| Wednesday, June 10 |
| » Lost to Dodgers (31-25), 4-2 | Dodger Stadium (1-1) | 25-27 | |
| » Starters: Mike Torrez vs Joe Moeller | Fourth | 4½ out |
| Thursday, June 11 |
| » Lost to Dodgers (32-25), 2-1 | Dodger Stadium (1-2) | 25-28 | Lost 2 |
| » Starters: Steve Carlton vs Don Sutton | Fourth | 5½ out |
| Friday, June 12 |
| » Defeated Giants (26-32), 4-1 | Candlestick Park (1-0) | 26-28 | |
| » Starters: Bob Gibson vs Skip Pitlock | Fourth | 5½ out |
| » Major-league debuts: Skip Pitlock (Giants) |
| Saturday, June 13 |
| » Lost to Giants (27-32), 6-5 | Candlestick Park (1-1) | 26-29 | |
| » Starters: Nelson Briles vs Rich Robertson | Fourth | 6½ out |
| Sunday, June 14 |
| » Lost to Giants (28-32), 7-4 | Candlestick Park (1-2) | 26-30 | Lost 2 |
| » Starters: Chuck Taylor vs Juan Marichal | Fourth | 6½ out |
| » Major-league debuts: Jim Kennedy (Cardinals) |
| Monday, June 15 |
| » Defeated Padres (28-38), 5-4 | San Diego/Jack Murphy Stadium (1-0) | 27-30 | |
| » Starters: Mike Torrez vs Pat Dobson | Fourth | 6 out |
| Tuesday, June 16 |
| » Lost to Padres (29-38), 4-0 | San Diego/Jack Murphy Stadium (1-1) | 27-31 | |
| » Starters: Steve Carlton vs Mike Corkins | Fourth | 6 out |
| Wednesday, June 17 |
| » Defeated Padres (29-39), 8-0 | San Diego/Jack Murphy Stadium (2-1) | 28-31 | |
| » Starters: Bob Gibson vs Danny Coombs | Fourth | 6 out |
| Friday, June 19 |
| » Defeated Cubs (34-25), 5-3 | Wrigley Field (1-2) | 29-31 | Won 2 |
| » Starters: Chuck Taylor vs Joe Decker | Fourth | 5½ out |
| Saturday, June 20 |
| » Lost to Cubs (35-25), 8-3 | Wrigley Field (1-3) | 29-32 | |
| » Starters: Mike Torrez vs Bill Hands | Fourth | 6½ out |
| Sunday, June 21 |
| » Defeated Cubs (35-26), 3-0 | Wrigley Field (2-3) | 30-32 | |
| » Starters: Steve Carlton vs Ken Holtzman | Fourth | 4½ out |
| » Defeated Cubs (35-27), 3-2 | Wrigley Field (3-3) | 31-32 | Won 2 |
| » Starters: Bob Gibson vs Jim Colborn | Fourth | 4½ out |
| Monday, June 22 |
| » Defeated Pirates (33-35), 6-1 | Forbes Field (3-0) | 32-32 | Won 3 |
| » Starters: Jerry Reuss vs Dock Ellis | Fourth | 4 out |
| » Lost to Pirates (34-35), 1-0 | Forbes Field (3-1) | 32-33 | |
| » Starters: Mike Torrez vs Jim Nelson | Fourth | 4 out |
| Tuesday, June 23 |
| » Lost to Pirates (35-35), 7-2 | Forbes Field (3-2) | 32-34 | Lost 2 |
| » Starters: Chuck Taylor vs Bob Moose | Fourth | 4 out |
| Wednesday, June 24 |
| » Lost to Pirates (36-35), 4-3 | Forbes Field (3-3) | 32-35 | Lost 3 |
| » Starters: Al Hrabosky vs Steve Blass | Fourth | 4 out |
| Thursday, June 25 |
| » Lost to Pirates (37-35), 3-2 | Forbes Field (3-4) | 32-36 | Lost 4 |
| » Starters: Steve Carlton vs Bob Veale | Fourth | 5 out |
| Friday, June 26 |
| » Defeated Phillies (31-37), 7-0 | Busch Stadium II (15-15) | 33-36 | |
| » Starters: Rick Wise vs Bob Gibson | Fourth | 4 out |
| Saturday, June 27 |
| » Defeated Phillies (31-38), 9-8 | Busch Stadium II (16-15) | 34-36 | Won 2 |
| » Starters: Woodie Fryman vs Jerry Reuss | Fourth | 4 out |
| Future Cardinal Jim Edmonds is born in Fullerton, CA. |
| Sunday, June 28 |
| » Defeated Phillies (31-39), 5-4 | Busch Stadium II (17-15) | 35-36 | Won 3 |
| » Starters: Jim Bunning vs Mike Torrez | Fourth | 3½ out |
| » Lost to Phillies (32-39), 8-3 | Busch Stadium II (17-16) | 35-37 | |
| » Starters: Chris Short vs Chuck Taylor | Fourth | 3½ out |
| Monday, June 29 |
| » Defeated Cubs (35-36), 8-6 | Busch Stadium II (18-16) | 36-37 | |
| » Starters: Ken Holtzman vs Steve Carlton | Fourth | 3½ out |
| Tuesday, June 30 |
| » Defeated Cubs (35-37), 5-4 | Busch Stadium II (19-16) | 37-37 | Won 2 |
| » Starters: Joe Decker vs Bob Gibson | Third | 3½ out |
| Wednesday, July 1 |
| » Lost to Cubs (36-37), 5-0 | Busch Stadium II (19-17) | 37-38 | |
| » Starters: Fergie Jenkins vs Jerry Reuss | Fourth | 3½ out |
| Thursday, July 2 |
| » Lost to Expos (32-44), 13-10 | Parc Jarry (2-1) | 37-39 | Lost 2 |
| » Starters: Mike Torrez vs Carl Morton | Fourth | 3 out |
| Friday, July 3 |
| » Defeated Expos (32-45), 9-7 | Parc Jarry (3-1) | 38-39 | |
| » Starters: Chuck Taylor vs Bill Stoneman | Third | 3 out |
| Saturday, July 4 |
| » Lost to Expos (33-45), 8-0 | Parc Jarry (3-2) | 38-40 | |
| » Starters: Steve Carlton vs Steve Renko | Fourth | 4 out |
| Sunday, July 5 |
| » Defeated Expos (33-46), 6-3 | Parc Jarry (4-2) | 39-40 | |
| » Starters: Bob Gibson vs Rich Nye | Third | 4 out |
| Monday, July 6 |
| » Lost to Mets (44-36), 10-3 | Shea Stadium (1-3) | 39-41 | |
| » Starters: Jerry Reuss vs Jim McAndrew | Fourth | 5 out |
| Tuesday, July 7 |
| » Lost to Mets (45-36), 4-3 | Shea Stadium (1-4) | 39-42 | Lost 2 |
| » Starters: Mike Torrez vs Gary Gentry | Fourth | 6 out |
| Former Cardinal Harry Wolter dies in Palo Alto, CA at the age of 86. |
| Wednesday, July 8 |
| » Lost to Mets (46-36), 7-5 | Shea Stadium (1-5) | 39-43 | Lost 3 |
| » Starters: Nelson Briles vs Ray Sadecki | Fourth | 7 out |
| Thursday, July 9 |
| » Lost to Pirates (47-39), 6-0 | Busch Stadium II (19-18) | 39-44 | Lost 4 |
| » Starters: Dock Ellis vs Steve Carlton | Fourth | 8 out |
| Friday, July 10 |
| » Lost to Pirates (48-39), 6-2 | Busch Stadium II (19-19) | 39-45 | Lost 5 |
| » Starters: Jim Nelson vs Bob Gibson | Fourth | 8 out |
| Saturday, July 11 |
| » Lost to Pirates (49-39), 8-7 | Busch Stadium II (19-20) | 39-46 | Lost 6 |
| » Starters: Bob Veale vs Jerry Reuss | Fourth | 8½ out |
| Sunday, July 12 |
| » Lost to Pirates (50-39), 7-6 | Busch Stadium II (19-21) | 39-47 | Lost 7 |
| » Starters: Steve Blass vs Mike Torrez | Fourth | 9½ out |
| » Major-league debuts: Ed Crosby (Cardinals) |
| Thursday, July 16 |
| » Lost to Braves (43-44), 7-3 | Busch Stadium II (19-22) | 39-48 | Lost 8 |
| » Starters: Pat Jarvis vs Steve Carlton | Fourth | 9½ out |
| Friday, July 17 |
| » Defeated Braves (43-45), 11-6 | Busch Stadium II (20-22) | 40-48 | |
| » Starters: George Stone vs Nelson Briles | Fourth | 9½ out |
| Saturday, July 18 |
| » Lost to Braves (44-45), 8-7 | Busch Stadium II (20-23) | 40-49 | |
| » Starters: Jim Nash vs Bob Gibson | Fourth | 9½ out |
| Sunday, July 19 |
| » Defeated Braves (44-46), 3-1 | Busch Stadium II (21-23) | 41-49 | |
| » Starters: Ron Reed vs Mike Torrez | Fourth | 9½ out |
| Monday, July 20 |
| » Lost to Reds (65-28), 4-3 | Busch Stadium II (21-24) | 41-50 | |
| » Starters: Gary Nolan vs Jerry Reuss | Fifth | 10 out |
| » Lost to Reds (66-28), 4-0 | Busch Stadium II (21-25) | 41-51 | Lost 2 |
| » Starters: Tony Cloninger vs Chuck Taylor | Fifth | 10 out |
| Tuesday, July 21 |
| » Lost to Reds (67-28), 6-5 | Busch Stadium II (21-26) | 41-52 | Lost 3 |
| » Starters: Wayne Simpson vs Steve Carlton | Fifth | 10 out |
| Wednesday, July 22 |
| » Lost to Astros (42-53), 13-9 | Busch Stadium II (21-27) | 41-53 | Lost 4 |
| » Starters: Larry Dierker vs Nelson Briles | Fifth | 11 out |
| Thursday, July 23 |
| » Lost to Astros (43-53), 3-2 | Busch Stadium II (21-28) | 41-54 | Lost 5 |
| » Starters: Jack Billingham vs Bob Gibson | Fifth | 12 out |
| Friday, July 24 |
| » Lost to Reds (68-30), 4-0 | Riverfront Stadium (0-1) | 41-55 | Lost 6 |
| » Starters: Mike Torrez vs Gary Nolan | Fifth | 13 out |
| Saturday, July 25 |
| » Lost to Reds (69-30), 5-3 | Riverfront Stadium (0-2) | 41-56 | Lost 7 |
| » Starters: Jerry Reuss vs Tony Cloninger | Sixth | 13 out |
| Former Cardinal Herb Hunter dies in Orlando, FL at the age of 74. |
| Sunday, July 26 |
| » Lost to Reds (70-30), 12-5 | Riverfront Stadium (0-3) | 41-57 | Lost 8 |
| » Starters: Steve Carlton vs Wayne Simpson | Sixth | 13 out |
| Monday, July 27 |
| » Defeated Reds (70-31), 16-9 | Riverfront Stadium (1-3) | 42-57 | |
| » Starters: Nelson Briles vs Jim Merritt | Fifth | 12½ out |
| Tuesday, July 28 |
| » Defeated Braves (48-52), 6-4 | Atlanta-Fulton County Stadium (2-2) | 43-57 | Won 2 |
| » Starters: Bob Gibson vs Jim Nash | Fifth | 12½ out |
| Wednesday, July 29 |
| » Lost to Braves (49-52), 9-7 | Atlanta-Fulton County Stadium (2-3) | 43-58 | |
| » Starters: Mike Torrez vs Ron Reed | Sixth | 12½ out |
| Thursday, July 30 |
| » Defeated Braves (49-53), 4-2 | Atlanta-Fulton County Stadium (3-3) | 44-58 | |
| » Starters: Jerry Reuss vs Phil Niekro | Fifth | 11½ out |
| Friday, July 31 |
| » Defeated Astros (46-57), 5-1 | Astrodome (3-1) | 45-58 | Won 2 |
| » Starters: Steve Carlton vs Ron Cook | Fifth | 11 out |
| Saturday, August 1 |
| » Defeated Astros (46-58), 14-7 | Astrodome (4-1) | 46-58 | Won 3 |
| » Starters: Nelson Briles vs Don Wilson | Fifth | 11 out |
| Sunday, August 2 |
| » Defeated Astros (46-59), 3-2 | Astrodome (5-1) | 47-58 | Won 4 |
| » Starters: Bob Gibson vs Jack Billingham | Fifth | 10½ out |
| Monday, August 3 |
| » Defeated Phillies (49-55), 4-1 | Shibe Park (3-2) | 48-58 | Won 5 |
| » Starters: Mike Torrez vs Grant Jackson | Fifth | 9½ out |
| Tuesday, August 4 |
| » Defeated Phillies (49-56), 3-2 | Shibe Park (4-2) | 49-58 | Won 6 |
| » Starters: Jerry Reuss vs Chris Short | Fifth | 9½ out |
| Wednesday, August 5 |
| » Lost to Mets (58-49), 5-3 | Busch Stadium II (21-29) | 49-59 | |
| » Starters: Danny Frisella vs Steve Carlton | Fifth | 10½ out |
| Thursday, August 6 |
| » Defeated Mets (58-50), 3-0 | Busch Stadium II (22-29) | 50-59 | |
| » Starters: Tom Seaver vs Nelson Briles | Fourth | 11 out |
| Friday, August 7 |
| » Defeated Expos (48-64), 2-1 | Busch Stadium II (23-29) | 51-59 | Won 2 |
| » Starters: Dan McGinn vs Bob Gibson | Fourth | 11 out |
| Future Cardinal Rick Croushore is born in Lakehurst, NJ. |
| Saturday, August 8 |
| » Defeated Expos (48-65), 11-10 | Busch Stadium II (24-29) | 52-59 | Won 3 |
| » Starters: Mike Marshall vs Harry Parker | Fourth | 10 out |
| » Major-league debuts: Harry Parker (Cardinals) |
| Sunday, August 9 |
| » Lost to Expos (49-65), 7-6 | Busch Stadium II (24-30) | 52-60 | |
| » Starters: Mike Wegener vs Steve Carlton | Fourth | 10½ out |
| » Defeated Expos (49-66), 4-0 | Busch Stadium II (25-30) | 53-60 | |
| » Starters: Bill Stoneman vs Jerry Reuss | Fourth | 10½ out |
| Tuesday, August 11 |
| » Defeated Padres (45-70), 11-10 | Busch Stadium II (26-30) | 54-60 | Won 2 |
| » Starters: Earl Wilson vs Nelson Briles | Fourth | 9 out |
| Wednesday, August 12 |
| » Defeated Padres (45-71), 5-4 | Busch Stadium II (27-30) | 55-60 | Won 3 |
| » Starters: Danny Coombs vs Bob Gibson | Fourth | 8 out |
| Thursday, August 13 |
| » Lost to Padres (46-71), 9-7 | Busch Stadium II (27-31) | 55-61 | |
| » Starters: Clay Kirby vs Reggie Cleveland | Fourth | 8½ out |
| Friday, August 14 |
| » Defeated Giants (56-60), 2-1 | Busch Stadium II (28-31) | 56-61 | |
| » Starters: Juan Marichal vs Steve Carlton | Fourth | 9½ out |
| » Lost to Giants (57-60), 5-4 | Busch Stadium II (28-32) | 56-62 | |
| » Starters: Skip Pitlock vs Jerry Reuss | Fourth | 9½ out |
| Saturday, August 15 |
| » Lost to Giants (58-60), 3-2 | Busch Stadium II (28-33) | 56-63 | Lost 2 |
| » Starters: Frank Reberger vs Nelson Briles | Fourth | 10½ out |
| Sunday, August 16 |
| » Lost to Giants (59-60), 5-2 | Busch Stadium II (28-34) | 56-64 | Lost 3 |
| » Starters: Ron Bryant vs Harry Parker | Fourth | 10½ out |
| Monday, August 17 |
| » Defeated Dodgers (67-52), 11-8 | Busch Stadium II (29-34) | 57-64 | |
| » Starters: Don Sutton vs Bob Gibson | Fourth | 9½ out |
| Tuesday, August 18 |
| » Lost to Dodgers (68-52), 7-2 | Busch Stadium II (29-35) | 57-65 | |
| » Starters: Sandy Vance vs Jerry Reuss | Fourth | 10½ out |
| Wednesday, August 19 |
| » Lost to Dodgers (69-52), 4-2 | Busch Stadium II (29-36) | 57-66 | Lost 2 |
| » Starters: Joe Moeller vs Steve Carlton | Fourth | 10½ out |
| Friday, August 21 |
| » Defeated Padres (48-77), 14-8 | San Diego/Jack Murphy Stadium (3-1) | 58-66 | |
| » Starters: Nelson Briles vs Earl Wilson | Fourth | 9½ out |
| Saturday, August 22 |
| » Defeated Padres (48-78), 7-0 | San Diego/Jack Murphy Stadium (4-1) | 59-66 | Won 2 |
| » Starters: Bob Gibson vs Danny Coombs | Fourth | 9½ out |
| Sunday, August 23 |
| » Defeated Padres (48-79), 8-7 | San Diego/Jack Murphy Stadium (5-1) | 60-66 | Won 3 |
| » Starters: Jerry Reuss vs Clay Kirby | Fourth | 9½ out |
| Tuesday, August 25 |
| » Lost to Giants (64-62), 4-2 | Candlestick Park (1-3) | 60-67 | |
| » Starters: Steve Carlton vs Skip Pitlock | Fourth | 9½ out |
| Wednesday, August 26 |
| » Lost to Giants (65-62), 8-7 | Candlestick Park (1-4) | 60-68 | Lost 2 |
| » Starters: Nelson Briles vs Frank Reberger | Fourth | 9½ out |
| Thursday, August 27 |
| » Defeated Giants (65-63), 4-1 | Candlestick Park (2-4) | 61-68 | |
| » Starters: Bob Gibson vs Gaylord Perry | Fourth | 9 out |
| Friday, August 28 |
| » Defeated Dodgers (72-56), 1-0 | Dodger Stadium (2-2) | 62-68 | Won 2 |
| » Starters: Jerry Reuss vs Don Sutton | Fourth | 8 out |
| Saturday, August 29 |
| » Defeated Dodgers (72-57), 3-2 | Dodger Stadium (3-2) | 63-68 | Won 3 |
| » Starters: Frank Bertaina vs Alan Foster | Fourth | 7 out |
| Sunday, August 30 |
| » Defeated Dodgers (72-58), 2-1 | Dodger Stadium (4-2) | 64-68 | Won 4 |
| » Starters: Steve Carlton vs Sandy Vance | Fourth | 5½ out |
| Monday, August 31 |
| » Lost to Mets (68-64), 11-5 | Busch Stadium II (29-37) | 64-69 | |
| » Starters: Jerry Koosman vs Nelson Briles | Fourth | 6 out |
| Tuesday, September 1 |
| » Lost to Mets (69-64), 4-3 | Busch Stadium II (29-38) | 64-70 | Lost 2 |
| » Starters: Jim McAndrew vs Bob Gibson | Fourth | 7 out |
| Wednesday, September 2 |
| » Lost to Mets (70-64), 7-3 | Busch Stadium II (29-39) | 64-71 | Lost 3 |
| » Starters: Tom Seaver vs Jerry Reuss | Fourth | 7 out |
| Thursday, September 3 |
| » Defeated Mets (70-65), 5-3 | Busch Stadium II (30-39) | 65-71 | |
| » Starters: Gary Gentry vs Steve Carlton | Fourth | 6½ out |
| Friday, September 4 |
| » Lost to Expos (59-76), 9-7 | Busch Stadium II (30-40) | 65-72 | |
| » Starters: Steve Renko vs Mike Torrez | Fourth | 7½ out |
| » Major-league debuts: Jorge Roque (Cardinals) |
| Saturday, September 5 |
| » Lost to Expos (60-76), 6-0 | Busch Stadium II (30-41) | 65-73 | Lost 2 |
| » Starters: Bill Stoneman vs Frank Bertaina | Fourth | 8½ out |
| Sunday, September 6 |
| » Defeated Expos (60-77), 7-2 | Busch Stadium II (31-41) | 66-73 | |
| » Starters: John O'Donoghue vs Bob Gibson | Fourth | 8½ out |
| Monday, September 7 |
| » Lost to Phillies (64-75), 5-1 | Shibe Park (4-3) | 66-74 | |
| » Starters: Jerry Reuss vs Chris Short | Fourth | 9½ out |
| » Lost to Phillies (65-75), 3-2 | Shibe Park (4-4) | 66-75 | Lost 2 |
| » Starters: Mike Torrez vs Lowell Palmer | Fourth | 9½ out |
| » Major-league debuts: Luis Melendez (Cardinals) |
| Tuesday, September 8 |
| » Defeated Phillies (65-76), 6-3 | Shibe Park (5-4) | 67-75 | |
| » Starters: Steve Carlton vs Rick Wise | Fourth | 8½ out |
| Wednesday, September 9 |
| » Defeated Pirates (75-67), 6-4 | Three Rivers Stadium (1-0) | 68-75 | Won 2 |
| » Starters: Frank Bertaina vs Fred Cambria | Third | 7½ out |
| Thursday, September 10 |
| » Lost to Pirates (76-67), 2-0 | Three Rivers Stadium (1-1) | 68-76 | |
| » Starters: Nelson Briles vs Luke Walker | Third | 8½ out |
| Friday, September 11 |
| » Defeated Mets (76-68), 5-2 | Shea Stadium (2-5) | 69-76 | |
| » Starters: Bob Gibson vs Tom Seaver | Fourth | 8 out |
| » Major-league debuts: Tim Foli (Mets) |
| Saturday, September 12 |
| » Lost to Mets (77-68), 3-0 | Shea Stadium (2-6) | 69-77 | |
| » Starters: Jerry Reuss vs Jim McAndrew | Fourth | 9 out |
| Sunday, September 13 |
| » Defeated Mets (77-69), 5-4 | Shea Stadium (3-6) | 70-77 | |
| » Starters: Mike Torrez vs Gary Gentry | Fourth | 8 out |
| Tuesday, September 15 |
| » Lost to Cubs (77-69), 5-3 | Wrigley Field (3-4) | 70-78 | |
| » Starters: Steve Carlton vs Ken Holtzman | Fourth | 9 out |
| Wednesday, September 16 |
| » Defeated Cubs (77-70), 8-1 | Wrigley Field (4-4) | 71-78 | |
| » Starters: Bob Gibson vs Milt Pappas | Fourth | 9 out |
| Thursday, September 17 |
| » Defeated Cubs (77-71), 9-2 | Wrigley Field (5-4) | 72-78 | Won 2 |
| » Starters: Jerry Reuss vs Bill Hands | Fourth | 8 out |
| Friday, September 18 |
| » Lost to Phillies (68-83), 9-7 | Busch Stadium II (31-42) | 72-79 | |
| » Starters: Lowell Palmer vs Mike Torrez | Fourth | 9 out |
| Saturday, September 19 |
| » Lost to Phillies (69-83), 10-6 | |
