| Wednesday, February 19 |
| Former White Sox Doc White dies in Silver Spring, MD at the age of 90. |
| Friday, February 21 |
| Former White Sox Eddie Murphy dies in Dunmore, PA at the age of 78. |
| Sunday, February 23 |
| Former White Sox Bill Swift dies in Bartow, FL at the age of 62. |
| Sunday, March 23 |
| Former White Sox Oris Hockett dies in Torrance, CA at the age of 60. |
| Tuesday, April 1 |
| Future White Sox Frank Castillo is born in ElPaso, TX. |
| Monday, April 7 |
| » Major-league debuts: Bob Didier (Braves) |
| Tuesday, April 8 |
| » Lost to Athletics (1-0), 5-2 | Oakland-Alameda County Stadium (0-1) | 0-1 | |
| » W: Blue Moon Odom (1-0) L: Gary Peters (0-1) | Second | 1 out |
| Former White Sox Wynn Noyes dies in Cashmere, WA at the age of 80. |
| Wednesday, April 9 |
| » Defeated Athletics (1-1), 3-0 | Oakland-Alameda County Stadium (1-1) | 1-1 | |
| » W: Tommy John (1-0) L: Jim Nash (0-1) | Second | 1 out |
| Friday, April 11 |
| » Lost to Pilots (2-1), 7-0 | Sick's Stadium (0-1) | 1-2 | |
| » W: Gary Bell (1-0) L: Joe Horlen (0-1) | Second | 1 out |
| Saturday, April 12 |
| » Lost to Pilots (3-1), 5-1 | Sick's Stadium (0-2) | 1-3 | Lost 2 |
| » W: Diego Segui (1-0) L: Sammy Ellis (0-1) S: Jack Aker (2) | Third | 2 out |
| Sunday, April 13 |
| » Defeated Pilots (3-2), 12-7 | Sick's Stadium (1-2) | 2-3 | |
| » W: Wilbur Wood (1-0) L: Marty Pattin (1-1) | Fourth | 1½ out |
| Monday, April 14 |
| » Defeated Angels (3-3), 4-3 | Anaheim Stadium (1-0) | 3-3 | Won 2 |
| » W: Tommy John (2-0) L: Hoyt Wilhelm (0-1) S: Bob Locker (1) | Second | 1½ out |
| Wednesday, April 16 |
| » Defeated Royals (5-3), 5-2 | Comiskey Park I (1-0) | 4-3 | Won 3 |
| » W: Joe Horlen (1-1) L: Dave Morehead (0-2) | Second | ½ out |
| Saturday, April 19 |
| » Lost to Pilots (4-4), 5-1 | Comiskey Park I (1-1) | 4-4 | |
| » W: Marty Pattin (2-1) L: Gary Peters (0-2) S: Diego Segui (1) | Second | ½ out |
| Sunday, April 20 |
| » Defeated Pilots (4-5), 3-2 | Comiskey Park I (2-1) | 5-4 | |
| » W: Wilbur Wood (2-0) L: Diego Segui (1-1) | First | -- |
| » Defeated Pilots (4-6), 13-3 | Comiskey Park I (3-1) | 6-4 | Won 2 |
| » W: Joe Horlen (2-1) L: Steve Barber (0-1) S: Bob Locker (2) | First | -- |
| Tuesday, April 22 |
| » Lost to Angels (4-7), 8-0 | Comiskey Park I (3-2) | 6-5 | |
| » W: Jim McGlothlin (1-1) L: Sammy Ellis (0-2) | Second | ½ out |
| Wednesday, April 23 |
| » Defeated Angels (4-8), 7-1 | County Stadium (1-0) | 7-5 | |
| » W: Gary Peters (1-2) L: George Brunet (1-2) | Second | ½ out |
| Friday, April 25 |
| » Defeated Twins (8-7), 6-5 | Comiskey Park I (4-2) | 8-5 | Won 2 |
| » W: Bob Locker (1-0) L: Ron Perranoski (3-1) | First | -- |
| Saturday, April 26 |
| » Lost to Twins (9-7), 12-1 | Comiskey Park I (4-3) | 8-6 | |
| » W: Dean Chance (2-0) L: Joe Horlen (2-2) S: Joe Grzenda (1) | First | -- |
| Sunday, April 27 |
| » Lost to Twins (10-7), 4-3 | Comiskey Park I (4-4) | 8-7 | Lost 2 |
| » W: Dave Boswell (2-2) L: Gary Peters (1-3) | Third | 1 out |
| Wednesday, April 30 |
| » Lost to Royals (9-10), 3-2 | Municipal Stadium (0-1) | 8-8 | Lost 3 |
| » W: Moe Drabowsky (3-1) L: Wilbur Wood (2-1) | Third | 3 out |
| Thursday, May 1 |
| » Lost to Royals (10-10), 5-4 | Municipal Stadium (0-2) | 8-9 | Lost 4 |
| » W: Dave Wickersham (1-0) L: Sammy Ellis (0-3) | Fourth | 4 out |
| Saturday, May 3 |
| » Lost to Twins (15-7), 3-1 | Metropolitan Stadium (0-1) | 8-10 | Lost 5 |
| » Manager: Don Gutteridge |
| » W: Jim Perry (3-1) L: Gary Peters (1-4) S: Ron Perranoski (4) | Fourth | 5 out |
| Sunday, May 4 |
| » Lost to Twins (16-7), 4-3 | Metropolitan Stadium (0-2) | 8-11 | Lost 6 |
| » W: Joe Grzenda (1-1) L: Bob Locker (1-1) S: Ron Perranoski (5) | Fourth | 6 out |
| Monday, May 5 |
| Former White Sox Eddie Cicotte dies in Detroit, MI at the age of 85. |
| Tuesday, May 6 |
| » Defeated Orioles (20-9), 1-0 | Memorial Stadium (1-0) | 9-11 | |
| » W: Joe Horlen (3-2) L: Jim Palmer (3-2) | Fourth | 5 out |
| Wednesday, May 7 |
| » Defeated Orioles (20-10), 6-4 | Memorial Stadium (2-0) | 10-11 | Won 2 |
| » W: Gary Peters (2-4) L: Mike Cuellar (3-3) S: Bob Locker (3) | Fourth | 5 out |
| Saturday, May 10 |
| » Defeated Indians (4-20), 4-0 | Cleveland Stadium (1-0) | 11-11 | Won 3 |
| » W: Tommy John (3-0) L: Sam McDowell (2-4) S: Bob Locker (4) | Fourth | 5 out |
| Sunday, May 11 |
| » Defeated Indians (4-21), 7-5 | Cleveland Stadium (2-0) | 12-11 | Won 4 |
| » W: Bob Locker (2-1) L: Stan Williams (0-4) S: Dan Osinski (1) | Third | 4 out |
| Tuesday, May 13 |
| » Lost to Tigers (14-15), 3-1 | Tiger Stadium (0-1) | 12-12 | |
| » W: Mickey Lolich (4-1) L: Bob Locker (2-2) S: Pat Dobson (4) | Third | 5 out |
| Future White Sox Lyle Mouton is born in Lafayette, LA. |
| Wednesday, May 14 |
| » Defeated Tigers (14-16), 6-0 | Tiger Stadium (1-1) | 13-12 | |
| » W: Gary Peters (3-4) L: John Hiller (1-1) | Third | 4 out |
| Thursday, May 15 |
| » Lost to Tigers (15-16), 2-1 | Tiger Stadium (1-2) | 13-13 | |
| » W: Pat Dobson (1-2) L: Bob Locker (2-3) | Third | 4½ out |
| Friday, May 16 |
| » Defeated Senators (17-19), 7-6 | Comiskey Park I (5-4) | 14-13 | |
| » W: Dan Osinski (1-0) L: Casey Cox (2-1) | Third | 4½ out |
| Future White Sox Mike Heathcott is born in Chicago, IL. |
| Saturday, May 17 |
| » Defeated Senators (17-20), 6-0 | Comiskey Park I (6-4) | 15-13 | Won 2 |
| » W: Jerry Nyman (1-0) L: Camilo Pascual (2-4) | Third | 3½ out |
| Sunday, May 18 |
| » Lost to Senators (18-20), 3-2 | Comiskey Park I (6-5) | 15-14 | |
| » W: Dave Baldwin (2-1) L: Joe Horlen (3-3) S: Dennis Higgins (8) | Third | 4½ out |
| » Lost to Senators (19-20), 3-2 | Comiskey Park I (6-6) | 15-15 | Lost 2 |
| » W: Dick Bosman (4-2) L: Gary Peters (3-5) S: Dennis Higgins (9) | Third | 4½ out |
| Tuesday, May 20 |
| » Lost to Tigers (18-16), 7-6 | Comiskey Park I (6-7) | 15-16 | Lost 3 |
| » W: Earl Wilson (2-4) L: Tommy John (3-1) S: Don McMahon (4) | Third | 4½ out |
| Thursday, May 22 |
| » Defeated Tigers (18-17), 7-3 | County Stadium (2-0) | 16-16 | |
| » W: Jerry Nyman (2-0) L: Denny McLain (6-4) S: Dan Osinski (2) | Third | 3½ out |
| Friday, May 23 |
| » Lost to Red Sox (25-13), 4-2 | Comiskey Park I (6-8) | 16-17 | |
| » W: Ray Culp (7-2) L: Joe Horlen (3-4) S: Vicente Romo (7) | Third | 3½ out |
| Saturday, May 24 |
| » Defeated Red Sox (25-14), 9-3 | Comiskey Park I (7-8) | 17-17 | |
| » W: Gary Peters (4-5) L: Lee Stange (1-4) | Second | 2½ out |
| Sunday, May 25 |
| » Lost to Red Sox (26-14), 1-0 | Comiskey Park I (7-9) | 17-18 | |
| » W: Jim Lonborg (3-0) L: Tommy John (3-2) S: Vicente Romo (8) | Fourth | 4 out |
| Tuesday, May 27 |
| » Lost to Yankees (21-24), 5-3 | Comiskey Park I (7-10) | 17-19 | Lost 2 |
| » W: Mel Stottlemyre (8-3) L: Wilbur Wood (2-2) | Fifth | 4½ out |
| Wednesday, May 28 |
| » Defeated Yankees (21-25), 7-6 | County Stadium (3-0) | 18-19 | |
| » W: Joe Horlen (4-4) L: Al Downing (0-2) S: Wilbur Wood (1) | Fourth | 3½ out |
| Friday, May 30 |
| » Lost to Senators (23-26), 5-4 | Robert F. Kennedy Stadium (0-1) | 18-20 | |
| » W: Darold Knowles (1-0) L: Cisco Carlos (0-1) | Third | 3 out |
| » Defeated Senators (23-27), 8-5 | Robert F. Kennedy Stadium (1-1) | 19-20 | |
| » W: Cisco Carlos (1-1) L: Jim Shellenback (0-1) | Third | 3 out |
| Saturday, May 31 |
| » Lost to Senators (24-27), 7-5 | Robert F. Kennedy Stadium (1-2) | 19-21 | |
| » W: Darold Knowles (2-0) L: Tommy John (3-3) | Third | 4 out |
| Sunday, June 1 |
| » Lost to Senators (25-27), 9-2 | Robert F. Kennedy Stadium (1-3) | 19-22 | Lost 2 |
| » W: Barry Moore (4-1) L: Jerry Nyman (2-1) | Fourth | 4 out |
| Monday, June 2 |
| » Defeated Red Sox (30-17), 6-4 | Fenway Park (1-0) | 20-22 | |
| » W: Cisco Carlos (2-1) L: Vicente Romo (1-4) S: Wilbur Wood (2) | Fourth | 4 out |
| Tuesday, June 3 |
| » Lost to Red Sox (31-17), 8-2 | Fenway Park (1-1) | 20-23 | |
| » W: Jim Lonborg (5-0) L: Gary Peters (4-6) | Fourth | 5 out |
| Wednesday, June 4 |
| » Defeated Red Sox (31-18), 7-2 | Fenway Park (2-1) | 21-23 | |
| » W: Tommy John (4-3) L: Sonny Siebert (4-6) | Third | 5 out |
| Friday, June 6 |
| » Lost to Yankees (25-28), 3-2 | Yankee Stadium (0-1) | 21-24 | |
| » W: Stan Bahnsen (2-8) L: Gary Peters (4-7) | Third | 5 out |
| » Major-league debuts: Angel Bravo (White Sox) |
| Saturday, June 7 |
| » Lost to Yankees (26-28), 6-2 | Yankee Stadium (0-2) | 21-25 | Lost 2 |
| » W: Fritz Peterson (8-6) L: Joe Horlen (4-5) | Third | 6 out |
| Sunday, June 8 |
| » Lost to Yankees (27-28), 3-1 | Yankee Stadium (0-3) | 21-26 | Lost 3 |
| » W: Mel Stottlemyre (9-4) L: Jerry Nyman (2-2) | Fourth | 6½ out |
| » Lost to Yankees (28-28), 11-2 | Yankee Stadium (0-4) | 21-27 | Lost 4 |
| » W: Bill Burbach (3-4) L: Cisco Carlos (2-2) | Fourth | 6½ out |
| Monday, June 9 |
| » Lost to Indians (18-32), 5-1 | Comiskey Park I (7-11) | 21-28 | Lost 5 |
| » W: Steve Hargan (1-2) L: Tommy John (4-4) S: Juan Pizarro (5) | Fourth | 6½ out |
| Tuesday, June 10 |
| » Defeated Indians (18-33), 9-5 | Comiskey Park I (8-11) | 22-28 | |
| » W: Cisco Carlos (3-2) L: Mike Paul (1-5) S: Wilbur Wood (3) | Fourth | 6½ out |
| Wednesday, June 11 |
| » Defeated Indians (18-34), 4-3 | County Stadium (4-0) | 23-28 | Won 2 |
| » W: Dan Osinski (2-0) L: Luis Tiant (3-8) S: Wilbur Wood (4) | Third | 5½ out |
| Friday, June 13 |
| » Lost to Orioles (41-17), 5-2 | Comiskey Park I (8-12) | 23-29 | |
| » W: Dave Leonhard (4-0) L: Gary Peters (4-8) | Fourth | 5½ out |
| Saturday, June 14 |
| » Lost to Orioles (42-17), 12-3 | Comiskey Park I (8-13) | 23-30 | Lost 2 |
| » W: Jim Palmer (8-2) L: Tommy John (4-5) S: Eddie Watt (6) | Fourth | 5½ out |
| Sunday, June 15 |
| » Lost to Orioles (43-17), 9-0 | Comiskey Park I (8-14) | 23-31 | Lost 3 |
| » W: Dave McNally (9-0) L: Jerry Nyman (2-3) | Fourth | 7 out |
| » Lost to Orioles (44-17), 13-2 | Comiskey Park I (8-15) | 23-32 | Lost 4 |
| » W: Tom Phoebus (7-1) L: Joe Horlen (4-6) | Fourth | 7 out |
| Monday, June 16 |
| » Defeated Pilots (26-32), 8-3 | County Stadium (5-0) | 24-32 | |
| » W: Billy Wynne (1-0) L: Mike Marshall (3-8) | Fourth | 7 out |
| Wednesday, June 18 |
| » Defeated Pilots (26-33), 7-3 | Comiskey Park I (9-15) | 25-32 | Won 2 |
| » W: Gary Peters (5-8) L: Gene Brabender (3-5) | Fourth | 7½ out |
| » Lost to Pilots (27-33), 6-5 | Comiskey Park I (9-16) | 25-33 | |
| » W: Bob Locker (3-3) L: Dan Osinski (2-1) | Fourth | 7½ out |
| Thursday, June 19 |
| » Defeated Pilots (27-34), 13-10 | Comiskey Park I (10-16) | 26-33 | |
| » W: Wilbur Wood (3-2) L: Mike Marshall (3-9) | Fourth | 7 out |
| Friday, June 20 |
| » Lost to Angels (21-39), 2-1 | Anaheim Stadium (1-1) | 26-34 | |
| » W: Ken Tatum (2-0) L: Dan Osinski (2-2) | Fourth | 7½ out |
| » Defeated Angels (21-40), 9-1 | Anaheim Stadium (2-1) | 27-34 | |
| » W: Paul Edmondson (1-0) L: Greg Washburn (0-1) | Fourth | 7½ out |
| Saturday, June 21 |
| » Lost to Angels (22-40), 4-1 | Anaheim Stadium (2-2) | 27-35 | |
| » W: Andy Messersmith (3-5) L: Joe Horlen (4-7) S: Ken Tatum (1) | Fourth | 7½ out |
| Sunday, June 22 |
| » Defeated Angels (22-41), 1-0 | Anaheim Stadium (3-2) | 28-35 | |
| » W: Billy Wynne (2-0) L: Jim McGlothlin (5-6) | Fourth | 7 out |
| Tuesday, June 24 |
| » Defeated Pilots (30-36), 6-4 | Sick's Stadium (2-2) | 29-35 | Won 2 |
| » W: Wilbur Wood (4-2) L: Bob Locker (3-4) | Third | 6 out |
| » Defeated Pilots (30-37), 7-6 | Sick's Stadium (3-2) | 30-35 | Won 3 |
| » W: Wilbur Wood (5-2) L: Diego Segui (6-3) | Third | 6 out |
| Wednesday, June 25 |
| » Lost to Pilots (31-37), 3-1 | Sick's Stadium (3-3) | 30-36 | |
| » W: John Gelnar (2-1) L: Paul Edmondson (1-1) S: Bob Locker (7) | Fourth | 7 out |
| Thursday, June 26 |
| » Lost to Pilots (32-37), 3-2 | Sick's Stadium (3-4) | 30-37 | Lost 2 |
| » W: Gene Brabender (5-5) L: Joe Horlen (4-8) | Fourth | 8 out |
| » Major-league debuts: Steve Hovley (Pilots) |
| Friday, June 27 |
| » Lost to Athletics (38-29), 1-0 | Oakland-Alameda County Stadium (1-2) | 30-38 | Lost 3 |
| » W: Blue Moon Odom (10-3) L: Billy Wynne (2-1) | Fourth | 8½ out |
| Saturday, June 28 |
| » Defeated Athletics (38-30), 6-2 | Oakland-Alameda County Stadium (2-2) | 31-38 | |
| » W: Tommy John (5-5) L: Jim Nash (4-5) | Fourth | 7½ out |
| Sunday, June 29 |
| » Lost to Athletics (39-30), 3-2 | Oakland-Alameda County Stadium (2-3) | 31-39 | |
| » W: Catfish Hunter (5-6) L: Gary Peters (5-9) | Fourth | 9½ out |
| » Lost to Athletics (40-30), 6-5 | Oakland-Alameda County Stadium (2-4) | 31-40 | Lost 2 |
| » W: Lew Krausse (1-3) L: Wilbur Wood (5-3) S: Paul Lindblad (4) | Fourth | 9½ out |
| Monday, June 30 |
| » Lost to Twins (41-33), 7-3 | Comiskey Park I (10-17) | 31-41 | Lost 3 |
| » W: Bob Miller (1-2) L: Joe Horlen (4-9) S: Ron Perranoski (13) | Fourth | 10 out |
| Tuesday, July 1 |
| » Lost to Twins (42-33), 10-5 | Comiskey Park I (10-18) | 31-42 | Lost 4 |
| » W: Dick Woodson (5-3) L: Wilbur Wood (5-4) | Fourth | 10 out |
| Wednesday, July 2 |
| » Lost to Twins (43-33), 4-2 | County Stadium (5-1) | 31-43 | Lost 5 |
| » W: Dave Boswell (10-8) L: Tommy John (5-6) S: Ron Perranoski (14) | Fifth | 11 out |
| Thursday, July 3 |
| » Defeated Twins (43-34), 5-4 | Comiskey Park I (11-18) | 32-43 | |
| » W: Dan Osinski (3-2) L: Ron Perranoski (4-4) | Fourth | 11 out |
| Friday, July 4 |
| » Lost to Angels (28-48), 7-3 | Comiskey Park I (11-19) | 32-44 | |
| » W: Rudy May (3-8) L: Wilbur Wood (5-5) S: Ken Tatum (5) | Fifth | 10½ out |
| » Defeated Angels (28-49), 3-1 | Comiskey Park I (12-19) | 33-44 | |
| » W: Joe Horlen (5-9) L: Clyde Wright (0-3) | Fifth | 10½ out |
| Saturday, July 5 |
| » Defeated Angels (28-50), 4-3 | Comiskey Park I (13-19) | 34-44 | Won 2 |
| » W: Billy Wynne (3-1) L: Rudy May (3-9) | Fifth | 10½ out |
| Sunday, July 6 |
| » Lost to Angels (29-50), 2-1 | Comiskey Park I (13-20) | 34-45 | |
| » W: Tom Murphy (5-7) L: Tommy John (5-7) | Fifth | 11½ out |
| Monday, July 7 |
| » Defeated Athletics (42-35), 2-0 | County Stadium (6-1) | 35-45 | |
| » W: Gary Peters (6-9) L: Lew Krausse (2-4) | Fourth | 11½ out |
| Tuesday, July 8 |
| » Lost to Athletics (43-35), 2-1 | Comiskey Park I (13-21) | 35-46 | |
| » W: Catfish Hunter (6-7) L: Paul Edmondson (1-2) | Fourth | 12 out |
| » Defeated Athletics (43-36), 5-2 | Comiskey Park I (14-21) | 36-46 | |
| » W: Joe Horlen (6-9) L: Jim Nash (4-6) S: Wilbur Wood (5) | Fourth | 12 out |
| Wednesday, July 9 |
| » Defeated Athletics (43-37), 5-3 | Comiskey Park I (15-21) | 37-46 | Won 2 |
| » W: Wilbur Wood (6-5) L: Paul Lindblad (4-2) | Fourth | 11 out |
| » Major-league debuts: Bill McNulty (Athletics) |
| Thursday, July 10 |
| » Lost to Athletics (44-37), 12-2 | Comiskey Park I (15-22) | 37-47 | |
| » W: Blue Moon Odom (12-3) L: Tommy John (5-8) | Fourth | 12 out |
| » Major-league debuts: Chuck Brinkman (White Sox) |
| Friday, July 11 |
| » Lost to Royals (37-49), 8-5 | Municipal Stadium (0-3) | 37-48 | Lost 2 |
| » W: Don O'Riley (1-1) L: Dan Osinski (3-3) S: Mike Hedlund (1) | Fourth | 13 out |
| Saturday, July 12 |
| » Lost to Royals (38-49), 7-0 | Municipal Stadium (0-4) | 37-49 | Lost 3 |
| » W: Jim Rooker (1-6) L: Joe Horlen (6-10) | Fifth | 14 out |
| Sunday, July 13 |
| » Lost to Royals (39-49), 8-4 | Municipal Stadium (0-5) | 37-50 | Lost 4 |
| » W: Wally Bunker (5-5) L: Jerry Nyman (2-4) S: Moe Drabowsky (9) | Fourth | 15 out |
| » Defeated Royals (39-50), 4-1 | Municipal Stadium (1-5) | 38-50 | |
| » W: Cisco Carlos (4-2) L: Mike Hedlund (2-4) S: Wilbur Wood (6) | Fourth | 15 out |
| Monday, July 14 |
| » Lost to Twins (54-35), 4-3 | Metropolitan Stadium (0-3) | 38-51 | |
| » W: Al Worthington (3-0) L: Wilbur Wood (6-6) | Fifth | 16 out |
| Wednesday, July 16 |
| » Lost to Twins (55-35), 9-8 | Metropolitan Stadium (0-4) | 38-52 | Lost 2 |
| » W: Al Worthington (4-0) L: Don Secrist (0-1) | Fifth | 18 out |
| » Lost to Twins (56-35), 6-3 | Metropolitan Stadium (0-5) | 38-53 | Lost 3 |
| » W: Jim Perry (9-4) L: Gary Peters (6-10) S: Ron Perranoski (18) | Fifth | 18 out |
| Thursday, July 17 |
| » Lost to Twins (57-35), 8-5 | Metropolitan Stadium (0-6) | 38-54 | Lost 4 |
| » W: Jim Kaat (10-6) L: Joe Horlen (6-11) S: Jerry Crider (1) | Fifth | 19 out |
| Friday, July 18 |
| » Defeated Royals (39-54), 6-1 | Comiskey Park I (16-22) | 39-54 | |
| » W: Tommy John (6-8) L: Wally Bunker (5-6) | Fourth | 17½ out |
| Saturday, July 19 |
| » Defeated Royals (39-55), 5-4 | Comiskey Park I (17-22) | 40-54 | Won 2 |
| » W: Wilbur Wood (7-6) L: Dick Drago (4-9) | Fourth | 17 out |
| Sunday, July 20 |
| » Lost to Royals (40-55), 8-6 | Comiskey Park I (17-23) | 40-55 | |
| » W: Moe Drabowsky (7-6) L: Dan Osinski (3-4) S: Wally Bunker (2) | Fifth | 19 out |
| » Lost to Royals (41-55), 3-2 | Comiskey Park I (17-24) | 40-56 | Lost 2 |
| » W: Bill Butler (5-5) L: Wilbur Wood (7-7) S: Dick Drago (1) | Fifth | 19 out |
| Thursday, July 24 |
| » Lost to Orioles (66-31), 5-2 | Memorial Stadium (2-1) | 40-57 | Lost 3 |
| » W: Mike Cuellar (11-9) L: Tommy John (6-9) S: Eddie Watt (10) | Fifth | 19 out |
| Friday, July 25 |
| » Lost to Orioles (67-31), 4-2 | Memorial Stadium (2-2) | 40-58 | Lost 4 |
| » W: Dave McNally (14-0) L: Gary Peters (6-11) S: Dick Hall (3) | Fifth | 20 out |
| Saturday, July 26 |
| » Lost to Orioles (68-31), 2-1 | Memorial Stadium (2-3) | 40-59 | Lost 5 |
| » W: Tom Phoebus (10-3) L: Joe Horlen (6-12) S: Pete Richert (7) | Fifth | 20 out |
| Sunday, July 27 |
| » Lost to Orioles (69-31), 17-0 | Memorial Stadium (2-4) | 40-60 | Lost 6 |
| » W: Jim Hardin (5-4) L: Billy Wynne (3-2) | Fifth | 21 out |
| Tuesday, July 29 |
| » Lost to Indians (41-61), 4-3 | Cleveland Stadium (2-1) | 40-61 | Lost 7 |
| » W: Ron Law (2-1) L: Cisco Carlos (4-3) | Sixth | 23 out |
| » Lost to Indians (42-61), 9-5 | Cleveland Stadium (2-2) | 40-62 | Lost 8 |
| » W: Steve Hargan (3-8) L: Jack Hamilton (0-3) S: Stan Williams (8) | Sixth | 23 out |
| Wednesday, July 30 |
| » Defeated Indians (42-62), 11-6 | Cleveland Stadium (3-2) | 41-62 | |
| » W: Joe Horlen (7-12) L: Sam McDowell (11-10) S: Wilbur Wood (7) | Sixth | 22 out |
| Thursday, July 31 |
| » Lost to Indians (43-62), 3-2 | Cleveland Stadium (3-3) | 41-63 | |
| » W: Mike Paul (3-8) L: Jack Hamilton (0-4) | Sixth | 23 out |
| Friday, August 1 |
| » Lost to Tigers (57-45), 8-0 | Tiger Stadium (1-3) | 41-64 | Lost 2 |
| » W: Denny McLain (16-6) L: Paul Edmondson (1-3) | Sixth | 24 out |
| Saturday, August 2 |
| » Defeated Tigers (57-46), 5-0 | Tiger Stadium (2-3) | 42-64 | |
| » W: Gary Peters (7-11) L: Mickey Lolich (14-4) | Fifth | 23 out |
| Sunday, August 3 |
| » Lost to Tigers (58-46), 6-2 | Tiger Stadium (2-4) | 42-65 | |
| » W: Don McMahon (3-5) L: Dan Osinski (3-5) | Sixth | 24 out |
| Tuesday, August 5 |
| » Defeated Senators (56-56), 11-4 | Comiskey Park I (18-24) | 43-65 | |
| » W: Billy Wynne (4-2) L: Jim Shellenback (4-6) S: Wilbur Wood (8) | Fifth | 23½ out |
| Wednesday, August 6 |
| » Lost to Senators (57-56), 4-3 | County Stadium (6-2) | 43-66 | |
| » W: Dennis Higgins (9-8) L: Wilbur Wood (7-8) | Fifth | 24½ out |
| Friday, August 8 |
| » Lost to Tigers (61-48), 7-3 | Comiskey Park I (18-25) | 43-67 | Lost 2 |
| » W: Joe Sparma (6-8) L: Joe Horlen (7-13) S: Pat Dobson (8) | Sixth | 24½ out |
| » Lost to Tigers (62-48), 9-7 | Comiskey Park I (18-26) | 43-68 | Lost 3 |
| » W: Fred Lasher (2-0) L: Paul Edmondson (1-4) S: John Hiller (2) | Sixth | 24½ out |
| Saturday, August 9 |
| » Lost to Tigers (63-48), 8-4 | Comiskey Park I (18-27) | 43-69 | Lost 4 |
| » W: Denny McLain (17-6) L: Jack Hamilton (0-5) S: Tom Timmermann (1) | Sixth | 24½ out |
| Sunday, August 10 |
| » Lost to Tigers (64-48), 8-2 | Comiskey Park I (18-28) | 43-70 | Lost 5 |
| » W: Mickey Lolich (15-5) L: Billy Wynne (4-3) | Sixth | 24½ out |
| Monday, August 11 |
| » Lost to Red Sox (61-53), 5-2 | Comiskey Park I (18-29) | 43-71 | Lost 6 |
| » W: Mike Nagy (7-2) L: Paul Edmondson (1-5) S: Sparky Lyle (12) | Sixth | 25 out |
| Tuesday, August 12 |
| » Defeated Red Sox (61-54), 10-5 | Comiskey Park I (19-29) | 44-71 | |
| » W: Dan Osinski (4-5) L: Sonny Siebert (9-10) S: Wilbur Wood (9) | Sixth | 24 out |
| Wednesday, August 13 |
| » Defeated Red Sox (61-55), 5-3 | County Stadium (7-2) | 45-71 | Won 2 |
| » W: Joe Horlen (8-13) L: Ray Culp (16-8) S: Danny Murphy (1) | Sixth | 24 out |
| Future White Sox Alex Fernandez is born in Miami Beach, FL. |
| Thursday, August 14 |
| » Lost to Yankees (59-58), 3-2 | Comiskey Park I (19-30) | 45-72 | |
| » W: Jack Aker (7-4) L: Wilbur Wood (7-9) S: Lindy McDaniel (4) | Sixth | 24½ out |
| Friday, August 15 |
| » Lost to Yankees (60-58), 2-1 | Comiskey Park I (19-31) | 45-73 | Lost 2 |
| » W: Fritz Peterson (13-12) L: Gary Peters (7-12) | Sixth | 25½ out |
| Saturday, August 16 |
| » Defeated Yankees (60-59), 5-4 | Comiskey Park I (20-31) | 46-73 | |
| » W: Wilbur Wood (8-9) L: Jack Aker (7-5) | Sixth | 24½ out |
| Sunday, August 17 |
| » Lost to Yankees (61-59), 5-2 | Comiskey Park I (20-32) | 46-74 | |
| » W: Mike Kekich (1-4) L: Paul Edmondson (1-6) S: Lindy McDaniel (5) | Sixth | 25½ out |
| Former White Sox Frank Shellenback dies in Newton, MA at the age of 71. |
| Tuesday, August 19 |
| » Lost to Senators (62-61), 3-1 | Robert F. Kennedy Stadium (1-4) | 46-75 | Lost 2 |
| » W: Casey Cox (8-5) L: Joe Horlen (8-14) S: Darold Knowles (8) | Sixth | 26 out |
| Former White Sox Alex Carrasquel dies in Caracas, Venezuela at the age of 58. |
| Wednesday, August 20 |
| » Lost to Senators (63-61), 4-1 | Robert F. Kennedy Stadium (1-5) | 46-76 | Lost 3 |
| » W: Dick Bosman (9-5) L: Tommy John (6-10) S: Darold Knowles (9) | Sixth | 26 out |
| » Major-league debuts: Dick Smith (Senators) |
| Friday, August 22 |
| » Defeated Red Sox (65-58), 4-1 | Fenway Park (3-1) | 47-76 | |
| » W: Gary Peters (8-12) L: Vicente Romo (4-9) | Sixth | 26 out |
| Saturday, August 23 |
| » Lost to Red Sox (66-58), 2-0 | Fenway Park (3-2) | 47-77 | |
| » W: Ray Culp (17-8) L: Billy Wynne (4-4) | Sixth | 27 out |
| Sunday, August 24 |
| » Defeated Red Sox (66-59), 3-1 | Fenway Park (4-2) | 48-77 | |
| » W: Joe Horlen (9-14) L: Jim Lonborg (7-7) S: Wilbur Wood (10) | Sixth | 27 out |
| Tuesday, August 26 |
| » Defeated Yankees (62-65), 3-2 | Yankee Stadium (1-4) | 49-77 | Won 2 |
| » W: Wilbur Wood (9-9) L: Lindy McDaniel (4-5) S: Danny Murphy (2) | Sixth | 26½ out |
| Wednesday, August 27 |
| » Lost to Yankees (63-65), 6-3 | Yankee Stadium (1-5) | 49-78 | |
| » W: Mel Stottlemyre (17-11) L: Gary Peters (8-13) | Sixth | 27½ out |
| Friday, August 29 |
| » Defeated Indians (54-77), 4-2 | Comiskey Park I (21-32) | 50-78 | |
| » W: Joe Horlen (10-14) L: Luis Tiant (8-17) | Fifth | 27½ out |
| Saturday, August 30 |
| » Defeated Indians (54-78), 6-5 | Comiskey Park I (22-32) | 51-78 | Won 2 |
| » W: Danny Murphy (1-0) L: Stan Williams (5-11) | Fifth | 26½ out |
| Sunday, August 31 |
| » Defeated Indians (54-79), 7-6 | Comiskey Park I (23-32) | 52-78 | Won 3 |
| » W: Dan Osinski (5-5) L: Ron Law (3-3) | Fourth | 26½ out |
| Monday, September 1 |
| » Lost to Orioles (92-43), 8-0 | County Stadium (7-3) | 52-79 | |
| » W: Jim Palmer (14-2) L: Billy Wynne (4-5) | Fifth | 27½ out |
| Tuesday, September 2 |
| » Defeated Orioles (92-44), 10-3 | Comiskey Park I (24-32) | 53-79 | |
| » W: Gary Peters (9-13) L: Dave McNally (17-6) S: Wilbur Wood (11) | Fifth | 27½ out |
| Thursday, September 4 |
| » Lost to Angels (57-76), 1-0 | Anaheim Stadium (3-3) | 53-80 | |
| » W: Rudy May (7-11) L: Tommy John (6-11) S: Ken Tatum (16) | Fifth | 29 out |
| » Major-league debuts: Jose Ortiz (White Sox) |
| Friday, September 5 |
| » Lost to Angels (58-76), 3-1 | Anaheim Stadium (3-4) | 53-81 | Lost 2 |
| » W: Tom Murphy (9-13) L: Joe Horlen (10-15) S: Ken Tatum (17) | Fifth | 29 out |
| Saturday, September 6 |
| » Lost to Angels (59-76), 2-1 | Anaheim Stadium (3-5) | 53-82 | Lost 3 |
| » W: Hoyt Wilhelm (5-7) L: Wilbur Wood (9-10) | Fifth | 30 out |
| Sunday, September 7 |
| » Defeated Angels (59-77), 4-1 | Anaheim Stadium (4-5) | 54-82 | |
| » W: Billy Wynne (5-5) L: Jim McGlothlin (7-14) | Fifth | 30 out |
| Monday, September 8 |
| » Lost to Pilots (53-85), 2-1 | Sick's Stadium (3-5) | 54-83 | |
| » W: Steve Barber (3-4) L: Bart Johnson (0-1) S: John Gelnar (3) | Fifth | 30½ out |
| » Lost to Pilots (54-85), 5-1 | Sick's Stadium (3-6) | 54-84 | Lost 2 |
| » W: Miguel Fuentes (1-0) L: Gary Peters (9-14) | Fifth | 30½ out |
| » Major-league debuts: Bart Johnson and Denny O'Toole (White Sox) |
| Wednesday, September 10 |
| » Defeated Twins (86-55), 3-2 | Comiskey Park I (25-32) | 55-84 | |
| » W: Tommy John (7-11) L: Tom Hall (8-5) S: Wilbur Wood (12) | Fifth | 30 out |
| Thursday, September 11 |
| » Defeated Twins (86-56), 4-0 | Comiskey Park I (26-32) | 56-84 | Won 2 |
| » W: Joe Horlen (11-15) L: Dave Boswell (16-11) | Fifth | 29 out |
| Friday, September 12 |
| » Lost to Athletics (78-64), 12-4 | Comiskey Park I (26-33) | 56-85 | |
| » W: Ed Sprague (1-1) L: Billy Wynne (5-6) | Fifth | 30 out |
| Saturday, September 13 |
| » Lost to Athletics (79-64), 4-0 | Comiskey Park I (26-34) | 56-86 | Lost 2 |
| » W: Fred Talbot (6-9) L: Wilbur Wood (9-11) | Sixth | 30 out |
| Sunday, September 14 |
| » Defeated Athletics (79-65), 12-8 | Comiskey Park I (27-34) | 57-86 | |
| » W: Gary Peters (10-14) L: Catfish Hunter (9-15) S: Danny Murphy (3) | Fifth | 28½ out |
| » Defeated Athletics (79-66), 9-8 | Comiskey Park I (28-34) | 58-86 | Won 2 |
| » W: Danny Murphy (2-0) L: Fred Talbot (6-10) | Fifth | 28½ out |
| Monday, September 15 |
| » Lost to Angels (64-81), 4-0 | Comiskey Park I (28-35) | 58-87 | |
| » W: Jim McGlothlin (8-15) L: Fred Rath (0-1) S: Ken Tatum (20) | Fifth | 29½ out |
| Future White Sox Herbert Perry is born in Live Oak, FL. |
| Tuesday, September 16 |
| » Defeated Angels (64-82), 7-4 | Comiskey Park I (29-35) | 59-87 | |
| » W: Bart Johnson (1-1) L: Rudy May (8-13) S: Wilbur Wood (13) | Fifth | 29 out |
| » Defeated Angels (64-83), 3-2 | Comiskey Park I (30-35) | 60-87 | Won 2 |
| » W: Joe Horlen (12-15) L: Clyde Wright (1-8) S: Danny Murphy (4) | Fifth | 29 out |
| Wednesday, September 17 |
| » Defeated Pilots (58-90), 6-4 | Comiskey Park I (31-35) | 61-87 | Won 3 |
| » W: Jerry Nyman (3-4) L: Marty Pattin (7-12) S: Wilbur Wood (14) | Fifth | 27½ out |
| » Defeated Pilots (58-91), 2-1 | Comiskey Park I (32-35) | 62-87 | Won 4 |
| » W: Billy Wynne (6-6) L: Skip Lockwood (0-1) | Fifth | 27½ out |
| Friday, September 19 |
| » Defeated Royals (63-87), 7-0 | Municipal Stadium (2-5) | 63-87 | Won 5 |
| » W: Tommy John (8-11) L: Dick Drago (10-12) | Fourth | 27 out |
| Saturday, September 20 |
| » Lost to Royals (64-87), 9-8 | Municipal Stadium (2-6) | 63-88 | |
| » W: Bill Butler (8-10) L: Gary Peters (10-15) S: Al Fitzmorris (1) | Fifth | 28 out |
| Sunday, September 21 |
| » Defeated Royals (64-88), 10-2 | Municipal Stadium (3-6) | 64-88 | |
| » W: Joe Horlen (13-15) L: Wally Bunker (11-11) | Fourth | 27 out |
| Tuesday, September 23 |
| » Lost to Athletics (82-71), 4-3 | Oakland-Alameda County Stadium (2-5) | 64-89 | |
| » W: Catfish Hunter (11-15) L: Bart Johnson (1-2) S: Lew Krausse (6) | Fourth | 29 out |
| » Lost to Athletics (83-71), 5-3 | Oakland-Alameda County Stadium (2-6) | 64-90 | Lost 2 |
| » W: Juan Pizarro (4-4) L: Billy Wynne (6-7) | Fourth | 29 out |
| Wednesday, September 24 |
| » Defeated Athletics (83-72), 2-1 | Oakland-Alameda County Stadium (3-6) | 65-90 | |
| » W: Tommy John (9-11) L: Chuck Dobson (14-13) | Fourth | 29 out |
| Thursday, September 25 |
| » Defeated Royals (64-92), 2-1 | Comiskey Park I (33-35) | 66-90 | Won 2 |
| » W: Wilbur Wood (10-11) L: Al Fitzmorris (1-1) | Fourth | 28 out |
| Friday, September 26 |
| » Lost to Royals (65-92), 5-3 | County Stadium (7-4) | 66-91 | |
| » W: Moe Drabowsky (10-9) L: Joe Horlen (13-16) | Fourth | 28 out |
| Saturday, September 27 |
| » Defeated Royals (65-93), 6-1 | Comiskey Park I (34-35) | 67-91 | |
| » W: Jerry Nyman (4-4) L: Jim Rooker (4-16) | Fourth | 27½ out |
| Sunday, September 28 |
| » Lost to Royals (66-93), 10-3 | Comiskey Park I (34-36) | 67-92 | |
| » W: Moe Drabowsky (11-9) L: Fred Rath (0-2) | Fourth | 28 out |
| Tuesday, September 30 |
| » Lost to Twins (96-64), 4-3 | Metropolitan Stadium (0-7) | 67-93 | Lost 2 |
| » W: Jim Kaat (14-13) L: Danny Murphy (2-1) | Fourth | 29 out |
| Wednesday, October 1 |
| » Defeated Twins (96-65), 4-3 | Metropolitan Stadium (1-7) | 68-93 | |
| » W: Billy Wynne (7-7) L: Dave Boswell (20-12) S: Wilbur Wood (15) | Fourth | 28 out |
| Thursday, October 2 |
| » Lost to Twins (97-65), 6-5 | Metropolitan Stadium (1-8) | 68-94 | |
| » W: Joe Grzenda (4-1) L: Bart Johnson (1-3) S: Ron Perranoski (31) | Fifth | 29 out |
| Sunday, October 12 |
| Future White Sox Jose Valentin is born in Manati, P.R. |
| Friday, October 17 |
| Future White Sox Chris Tremie is born in Houston, TX. |
| Saturday, October 25 |
| Future White Sox Larry Thomas is born in Miami, FL. |
| Sunday, November 23 |
| Future White Sox Doug Brady is born in Jacksonville, IL. |
| Tuesday, December 9 |
| Future White Sox Ramon Garcia is born in Guanare, Venezuela. |
| Monday, December 29 |
| Future White Sox Scott Ruffcorn is born in Austin, TX. |
Game information provided by Retrosheet (www.retrosheet.org) |